SIMILAR PATTERNS OF AMINO ACIDS FOR 6ECT_A_SAMA1300

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1akc ASPARTATE
AMINOTRANSFERASE

(Gallus gallus) 		PF00155
(Aminotran_1_2) 		5 GLY A 385
GLY A 364
ILE A 387
VAL A 370
LEU A 373
 None
 0.93A 6ectA-1akcA:
undetectable		 6ectA-1akcA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 GLY A 314
GLY A 318
GLU A 324
VAL A 325
LEU A 328
 None
 0.81A 6ectA-1b25A:
undetectable		 6ectA-1b25A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)

(Escherichia
coli) 		PF02219
(MTHFR) 		5 GLY A  61
SER A  72
PHE A  30
GLU A  28
VAL A  58
 None
None
None
FAD  A 395 ( 4.3A)
None
 0.94A 6ectA-1b5tA:
undetectable		 6ectA-1b5tA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cwu ENOYL ACP REDUCTASE

(Brassica napus) 		PF13561
(adh_short_C2) 		5 LEU A 137
GLY A  25
VAL A 134
LEU A 133
ILE A 132
 NAD  A 501 (-3.9A)
NAD  A 501 (-3.5A)
None
None
None
 0.98A 6ectA-1cwuA:
3.5		 6ectA-1cwuA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0c SULFURTRANSFERASE

(Azotobacter
vinelandii) 		PF00581
(Rhodanese) 		5 GLY A  91
GLY A 116
ASP A  89
ILE A 207
LEU A 241
 None
None
MG  A 378 ( 4.7A)
None
None
 1.04A 6ectA-1e0cA:
undetectable		 6ectA-1e0cA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fqk REGULATOR OF
G-PROTEIN SIGNALING
9

(Bos taurus) 		PF00615
(RGS) 		5 GLY B 327
GLY B 323
ILE B 363
LEU B 353
ILE B 350
 None
 0.92A 6ectA-1fqkB:
undetectable		 6ectA-1fqkB:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC

(Canis lupus) 		PF00561
(Abhydrolase_1) 		5 ASN A  73
LEU A 179
GLY A 155
GLY A 151
SER A  99
 BOG  A1006 ( 4.5A)
None
None
None
None
 1.06A 6ectA-1k8qA:
undetectable		 6ectA-1k8qA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 GLY A 222
GLY A 224
VAL A 496
LEU A 499
ILE A 500
 None
 0.92A 6ectA-1knrA:
2.2		 6ectA-1knrA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oed ACETYLCHOLINE
RECEPTOR PROTEIN,
GAMMA CHAIN

(Torpedo
marmorata) 		PF02932
(Neur_chan_memb) 		5 LEU E 464
SER E 234
VAL E 293
LEU E 296
ILE E 297
 None
 1.01A 6ectA-1oedE:
undetectable		 6ectA-1oedE:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 GLY A 275
ASP A 781
ILE A 786
SER A 155
GLU A 437
 None
 0.93A 6ectA-1ogyA:
2.5		 6ectA-1ogyA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		5 ASP A 111
GLU A 204
VAL A 191
LEU A 151
ILE A 150
 None
 0.00A 6ectA-1q5aA:
undetectable		 6ectA-1q5aA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs8 PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		6 LEU A 126
GLY A 127
ASP A 214
ILE A 136
LEU A  40
ILE A 103
 None
 1.26A 6ectA-1qs8A:
undetectable		 6ectA-1qs8A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8n KUNITZ TRYPSIN
INHIBITOR

(Delonix regia) 		PF00197
(Kunitz_legume) 		5 GLY A  58
ILE A  48
GLU A  19
VAL A  61
ILE A  81
 None
 0.87A 6ectA-1r8nA:
undetectable		 6ectA-1r8nA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhi HUMAN RHINOVIRUS 3
COAT PROTEIN

(Rhinovirus B) 		PF00073
(Rhv) 		6 LEU 3 208
GLY 3 119
ILE 3 155
SER 3 123
VAL 3 205
LEU 3  71
 None
 1.32A 6ectA-1rhi3:
undetectable		 6ectA-1rhi3:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ri3 MRNA CAPPING ENZYME

(Encephalitozoon
cuniculi) 		PF03291
(Pox_MCEL) 		5 GLY A  72
GLY A  74
ASP A  78
ILE A  95
SER A 123
 SAH  A 299 (-3.3A)
SAH  A 299 (-3.5A)
SAH  A 299 (-4.0A)
SAH  A 299 (-3.8A)
SAH  A 299 (-3.1A)
 0.50A 6ectA-1ri3A:
15.7		 6ectA-1ri3A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u83 PHOSPHOSULFOLACTATE
SYNTHASE

(Bacillus
subtilis) 		PF02679
(ComA) 		5 ASN A 229
LEU A 133
GLY A  77
ILE A  24
PHE A  81
 GOL  A1110 (-2.9A)
None
PO4  A1000 (-3.3A)
GOL  A1110 (-4.3A)
None
 1.06A 6ectA-1u83A:
undetectable		 6ectA-1u83A:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uqr 3-DEHYDROQUINATE
DEHYDRATASE

(Actinobacillus
pleuropneumoniae) 		PF01220
(DHquinase_II) 		5 ASN A   8
GLY A 131
GLY A 128
VAL A  99
ILE A  72
 None
 1.03A 6ectA-1uqrA:
undetectable		 6ectA-1uqrA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjo ALANINE--GLYOXYLATE
AMINOTRANSFERASE

(Nostoc sp. PCC
7120) 		PF00266
(Aminotran_5) 		5 GLY A 117
GLY A 120
ILE A  90
VAL A 123
ILE A 102
 None
 0.96A 6ectA-1vjoA:
undetectable		 6ectA-1vjoA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrp CREATINE KINASE, M
CHAIN

(Tetronarce
californica) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 ASP A 120
ILE A 336
GLU A 362
VAL A 361
ILE A 299
 None
 1.00A 6ectA-1vrpA:
undetectable		 6ectA-1vrpA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE

(Pyrococcus
horikoshii) 		PF08282
(Hydrolase_3) 		5 GLY A 217
GLY A 214
ILE A  29
VAL A 175
ILE A   6
 None
 1.03A 6ectA-1wr8A:
2.1		 6ectA-1wr8A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydg TRP REPRESSOR
BINDING PROTEIN WRBA

(Deinococcus
radiodurans) 		PF03358
(FMN_red) 		5 GLY A  29
GLY A  33
GLU A  35
VAL A  36
ILE A   9
 None
 1.05A 6ectA-1ydgA:
undetectable		 6ectA-1ydgA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzg ADP-RIBOSYLATION
FACTOR-LIKE 8

(Homo sapiens) 		PF00025
(Arf) 		5 LEU A  24
GLY A  68
VAL A  22
LEU A  89
ILE A  87
 None
 1.01A 6ectA-1yzgA:
undetectable		 6ectA-1yzgA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bw2 BYPASS OF FORESPORE
C

(Bacillus
subtilis) 		PF08955
(BofC_C)
PF08977
(BOFC_N) 		5 ASN A  72
GLY A  76
GLY A 119
GLU A  91
ILE A  97
 None
 1.05A 6ectA-2bw2A:
undetectable		 6ectA-2bw2A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfh TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 6B

(Homo sapiens) 		PF04051
(TRAPP) 		6 LEU C  47
GLY C 128
GLY C  44
SER C 137
LEU C 133
ILE C 135
 None
 1.42A 6ectA-2cfhC:
undetectable		 6ectA-2cfhC:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d57 AQUAPORIN-4

(Rattus
norvegicus) 		PF00230
(MIP) 		5 GLY A 146
GLY A 144
ILE A 223
VAL A  53
LEU A 133
 None
 0.97A 6ectA-2d57A:
undetectable		 6ectA-2d57A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		5 GLY A 633
GLY A 631
PHE A 599
GLU A 600
ILE A 609
 None
 0.99A 6ectA-2eyqA:
2.6		 6ectA-2eyqA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwf RING FINGER PROTEIN
41

(Homo sapiens) 		PF08941
(USP8_interact) 		5 GLY B 237
ILE B 280
VAL B 243
LEU B 246
ILE B 247
 None
 0.92A 6ectA-2gwfB:
undetectable		 6ectA-2gwfB:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8o GERANYLTRANSTRANSFER
ASE

(Agrobacterium
fabrum) 		PF00348
(polyprenyl_synt) 		5 LEU A 225
GLY A 111
ILE A 166
VAL A  93
ILE A 236
 None
 1.06A 6ectA-2h8oA:
undetectable		 6ectA-2h8oA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3t TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 6A

(Homo sapiens) 		PF04051
(TRAPP) 		6 LEU B  48
GLY B 129
GLY B  45
SER B 138
LEU B 134
ILE B 136
 None
 1.49A 6ectA-2j3tB:
undetectable		 6ectA-2j3tB:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3t TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 6A

(Homo sapiens) 		PF04051
(TRAPP) 		6 LEU B  48
GLY B 129
SER B 138
GLU B  50
LEU B 134
ILE B 136
 None
 1.36A 6ectA-2j3tB:
undetectable		 6ectA-2j3tB:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2npn PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN

(Corynebacterium
diphtheriae) 		PF00590
(TP_methylase) 		5 LEU A 214
GLY A 204
ILE A 240
VAL A 226
LEU A 229
 None
 1.04A 6ectA-2npnA:
undetectable		 6ectA-2npnA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o01 PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI,
CHLOROPLAST

(Spinacia
oleracea) 		PF02605
(PsaL) 		5 LEU L  58
GLY L 142
GLY L 146
GLU L  55
LEU L  51
 CLA  H1501 (-3.8A)
None
None
CLA  L1502 ( 3.4A)
None
 0.96A 6ectA-2o01L:
undetectable		 6ectA-2o01L:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1

(Saccharomyces
cerevisiae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 LEU A  73
GLY A 100
ILE A  97
VAL A  80
LEU A  83
 None
 0.86A 6ectA-2p4qA:
4.3		 6ectA-2p4qA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxt LIPASE

(Bacillus
subtilis) 		PF01674
(Lipase_2) 		5 LEU A 124
GLY A 172
GLY A 175
VAL A 100
ILE A 128
 None
 0.97A 6ectA-2qxtA:
undetectable		 6ectA-2qxtA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00583
(Acetyltransf_1)
PF00696
(AA_kinase) 		5 LEU A 259
GLY A 278
ILE A 281
LEU A 241
ILE A 242
 None
 1.05A 6ectA-2r98A:
2.6		 6ectA-2r98A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vt1 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS

(Shigella
flexneri) 		PF01312
(Bac_export_2) 		5 ASP B 321
GLU B 327
VAL B 328
LEU B 331
ILE B 332
 None
 0.99A 6ectA-2vt1B:
undetectable		 6ectA-2vt1B:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc0 ALANINE GLYOXYLATE
TRANSAMINASE

(Thermococcus
litoralis) 		PF00155
(Aminotran_1_2) 		5 LEU A 113
GLY A 107
GLY A 109
ILE A 255
SER A 246
 None
PMP  A 409 (-3.7A)
None
None
PMP  A 409 (-3.1A)
 1.04A 6ectA-2zc0A:
undetectable		 6ectA-2zc0A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajb PEROXISOMAL
BIOGENESIS FACTOR 3

(Homo sapiens) 		PF04882
(Peroxin-3) 		5 LEU A 179
GLY A 173
GLY A 175
ILE A 168
LEU A  76
 None
 0.98A 6ectA-3ajbA:
undetectable		 6ectA-3ajbA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cer POSSIBLE
EXOPOLYPHOSPHATASE-L
IKE PROTEIN

(Bifidobacterium
longum) 		PF02541
(Ppx-GppA) 		7 LEU A 130
GLY A 327
GLY A 331
ASP A  22
SER A 324
GLU A 159
ILE A 229
 None
None
None
SO4  A 346 (-3.0A)
None
SO4  A 344 ( 4.7A)
None
 1.44A 6ectA-3cerA:
undetectable		 6ectA-3cerA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3a BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01301
(Glyco_hydro_35) 		5 GLY A 482
GLU A 466
VAL A 465
LEU A 464
ILE A 463
 None
 0.98A 6ectA-3d3aA:
undetectable		 6ectA-3d3aA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db2 PUTATIVE
NADPH-DEPENDENT
OXIDOREDUCTASE

(Desulfitobacterium
hafniense) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 GLY A 246
GLY A 144
PHE A 277
GLU A 276
LEU A 251
 None
 1.03A 6ectA-3db2A:
3.7		 6ectA-3db2A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1w SUGAR ABC
TRANSPORTER

(Bacillus
halodurans) 		PF13407
(Peripla_BP_4) 		5 GLY A 236
GLY A 205
ASP A 208
SER A 257
ILE A 255
 None
 0.90A 6ectA-3g1wA:
2.9		 6ectA-3g1wA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd8 AQUAPORIN-4

(Homo sapiens) 		PF00230
(MIP) 		5 LEU A  50
GLY A 125
GLY A 129
PHE A  48
LEU A  43
 None
 1.02A 6ectA-3gd8A:
undetectable		 6ectA-3gd8A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2z MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE

(Shigella
flexneri) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 GLY A 227
GLY A 231
GLU A 291
VAL A 290
ILE A 235
 None
 0.92A 6ectA-3h2zA:
3.7		 6ectA-3h2zA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Mus musculus) 		PF00155
(Aminotran_1_2) 		5 GLY A 406
GLY A 385
ILE A 408
VAL A 391
LEU A 394
 None
 0.99A 6ectA-3hlmA:
undetectable		 6ectA-3hlmA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3l ALKYLHALIDASE CMLS

(Streptomyces
venezuelae) 		PF04820
(Trp_halogenase) 		5 GLY A 165
GLY A 167
ILE A   9
PHE A 299
LEU A 292
 FAD  A 600 (-3.6A)
None
FAD  A 600 ( 4.9A)
None
None
 0.97A 6ectA-3i3lA:
2.5		 6ectA-3i3lA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k3n PHD FINGER PROTEIN 8

(Homo sapiens) 		PF02373
(JmjC) 		5 GLY A 108
GLY A 132
ILE A 209
VAL A 127
ILE A 125
 None
 0.88A 6ectA-3k3nA:
undetectable		 6ectA-3k3nA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7n PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF00117
(GATase) 		5 GLY A 140
ILE A 113
VAL A 187
LEU A 190
ILE A 191
 None
 0.65A 6ectA-3l7nA:
undetectable		 6ectA-3l7nA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3loi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Branchiostoma
belcheri) 		PF06172
(Cupin_5) 		5 GLY A 128
GLU A  11
VAL A  12
LEU A  15
ILE A  16
 None
 0.92A 6ectA-3loiA:
undetectable		 6ectA-3loiA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgg METHYLTRANSFERASE

(Methanosarcina
mazei) 		PF13847
(Methyltransf_31) 		5 GLY A  43
GLY A  45
ILE A  67
GLU A 114
VAL A 112
 None
 0.97A 6ectA-3mggA:
14.0		 6ectA-3mggA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwu SERINE PROTEASE
HTRA1

(Homo sapiens) 		PF13365
(Trypsin_2) 		5 ASN A 290
GLY A 206
ILE A 282
GLU A 231
VAL A 184
 None
 0.98A 6ectA-3nwuA:
undetectable		 6ectA-3nwuA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR

(Pseudomonas
putida) 		PF00532
(Peripla_BP_1) 		6 LEU A 250
GLY A 186
PHE A 273
VAL A 244
LEU A 243
ILE A 182
 None
 1.10A 6ectA-3o75A:
3.2		 6ectA-3o75A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 GLY A 222
ASP A 300
VAL A 115
LEU A 118
ILE A 119
 None
 0.97A 6ectA-3oz6A:
undetectable		 6ectA-3oz6A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3l CYTOCHROME P450

(Streptomyces
thioluteus) 		PF00067
(p450) 		5 LEU A  47
GLY A 312
VAL A 297
LEU A  64
ILE A  65
 None
 1.02A 6ectA-3p3lA:
undetectable		 6ectA-3p3lA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf0 IMELYSIN-LIKE
PROTEIN

(Psychrobacter
arcticus) 		PF09375
(Peptidase_M75) 		5 GLY A 195
GLY A 192
VAL A 168
LEU A 171
ILE A 172
 None
 1.00A 6ectA-3pf0A:
undetectable		 6ectA-3pf0A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pua PHD FINGER PROTEIN 2

(Homo sapiens) 		PF02373
(JmjC) 		5 GLY A 110
GLY A 134
ILE A 211
VAL A 129
ILE A 127
 None
EDO  A   6 (-4.5A)
None
None
None
 0.88A 6ectA-3puaA:
undetectable		 6ectA-3puaA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rim TRANSKETOLASE

(Mycobacterium
tuberculosis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 245
GLU A 238
VAL A 237
LEU A 265
ILE A 263
 None
 1.02A 6ectA-3rimA:
2.6		 6ectA-3rimA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ruy ORNITHINE
AMINOTRANSFERASE

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		5 GLY A 231
ASP A 242
ILE A 228
SER A  50
LEU A 257
 None
None
LLP  A 255 ( 3.9A)
None
None
 1.05A 6ectA-3ruyA:
undetectable		 6ectA-3ruyA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2g ZINC-CONTAINING
ALCOHOL
DEHYDROGENASE
SUPERFAMILY

(Cupriavidus
pinatubonensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ASN A 321
LEU A  46
GLY A  14
ASP A  52
LEU A  17
 None
 0.89A 6ectA-3s2gA:
5.2		 6ectA-3s2gA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u78 LYSINE-SPECIFIC
DEMETHYLASE 7

(Homo sapiens) 		PF02373
(JmjC) 		5 LEU A 165
GLY A 143
ILE A 244
VAL A 162
ILE A 160
 None
 1.03A 6ectA-3u78A:
undetectable		 6ectA-3u78A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		5 GLY A 385
GLY A 364
ILE A 387
VAL A 370
LEU A 373
 None
 0.98A 6ectA-3wzfA:
2.1		 6ectA-3wzfA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbq PHIKZ039

(Pseudomonas
virus phiKZ) 		no annotation 5 GLY A  16
GLY A  14
ILE A 132
GLU A  21
ILE A 182
 None
GDP  A 999 (-3.3A)
GDP  A 999 (-4.1A)
None
None
 0.96A 6ectA-3zbqA:
undetectable		 6ectA-3zbqA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE

(Pseudomonas
aeruginosa) 		PF00202
(Aminotran_3) 		5 ASN A 285
GLY A 160
GLY A 155
GLU A 122
ILE A 128
 None
None
PXG  A 470 (-3.5A)
None
None
 0.97A 6ectA-4b98A:
undetectable		 6ectA-4b98A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE

(Pseudomonas
aeruginosa) 		PF00202
(Aminotran_3) 		5 ASN A 285
GLY A 160
GLY A 155
ILE A 224
GLU A 122
 None
None
PXG  A 470 (-3.5A)
None
None
 1.05A 6ectA-4b98A:
undetectable		 6ectA-4b98A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		5 GLY A 428
GLU A 434
VAL A 435
LEU A 438
ILE A 439
 None
 0.98A 6ectA-4cmnA:
undetectable		 6ectA-4cmnA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4io6 AVGLUR1 LIGAND
BINDING DOMAIN

(Adineta vaga) 		PF00497
(SBP_bac_3) 		5 GLY A  84
ILE A 209
VAL A  41
LEU A  44
ILE A  45
 None
 1.06A 6ectA-4io6A:
undetectable		 6ectA-4io6A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1v MOB KINASE ACTIVATOR
1A

(Homo sapiens) 		PF03637
(Mob1_phocein) 		5 PHE A 188
GLU A 192
VAL A 190
LEU A 195
ILE A 196
 None
 1.05A 6ectA-4j1vA:
undetectable		 6ectA-4j1vA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK

(Escherichia
coli) 		PF02733
(Dak1) 		6 LEU A  79
GLY A  52
GLY A  75
ILE A  86
SER A  50
ILE A 103
 None
GOL  A 401 (-2.9A)
None
None
None
None
 1.23A 6ectA-4lryA:
undetectable		 6ectA-4lryA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1i TRANSCRIPTIONAL
REGULATORY PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A  63
GLY A  57
GLY A  59
VAL A  48
LEU A   7
 None
 1.03A 6ectA-4o1iA:
undetectable		 6ectA-4o1iA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1m ENOYL-ACYL CARRIER
REDUCTASE

(Toxoplasma
gondii) 		PF13561
(adh_short_C2) 		5 LEU A 128
GLY A  16
VAL A 125
LEU A 124
ILE A 123
 NAD  A 401 (-4.0A)
NAD  A 401 (-3.9A)
None
None
None
 0.99A 6ectA-4o1mA:
4.8		 6ectA-4o1mA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5p UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF09994
(DUF2235) 		5 LEU A 332
GLY A 233
VAL A  90
LEU A  93
ILE A  94
 None
 1.03A 6ectA-4o5pA:
undetectable		 6ectA-4o5pA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4omb PHOSPHATE BINDING
PROTEIN

(Pseudomonas
aeruginosa) 		PF12849
(PBP_like_2) 		5 ASN A 133
GLY A 163
ILE A 135
VAL A 176
ILE A 225
 None
 0.97A 6ectA-4ombA:
undetectable		 6ectA-4ombA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pg6 HOMOSERINE
DEHYDROGENASE

(Staphylococcus
aureus) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		5 GLY A 307
ILE A  22
VAL A  77
LEU A   8
ILE A   6
 None
 1.03A 6ectA-4pg6A:
3.8		 6ectA-4pg6A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqj PHOSPHATE BINDING
PROTEIN

(Pseudomonas
aeruginosa) 		PF12849
(PBP_like_2) 		5 ASN A 133
GLY A 163
ILE A 135
VAL A 176
ILE A 225
 None
 0.97A 6ectA-4pqjA:
undetectable		 6ectA-4pqjA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9n ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Chlamydia
trachomatis) 		PF13561
(adh_short_C2) 		5 LEU A 127
GLY A  15
VAL A 124
LEU A 123
ILE A 122
 NAI  A 301 (-3.8A)
NAI  A 301 ( 4.3A)
None
None
None
 0.93A 6ectA-4q9nA:
4.3		 6ectA-4q9nA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl3 CHITINASE A

(Pteris
ryukyuensis) 		PF00704
(Glyco_hydro_18) 		5 GLY A 333
PHE A 305
VAL A 303
LEU A 302
ILE A 300
 None
 1.03A 6ectA-4rl3A:
undetectable		 6ectA-4rl3A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzh 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Synechocystis
sp. PCC 6803) 		PF13561
(adh_short_C2) 		5 GLY A 118
GLU A  70
VAL A  71
LEU A  74
ILE A  75
 None
 0.92A 6ectA-4rzhA:
5.9		 6ectA-4rzhA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE

(Pseudomonas sp.) 		PF00202
(Aminotran_3) 		5 ASN A 285
GLY A 160
GLY A 155
GLU A 122
ILE A 128
 None
None
PLP  A1458 (-3.5A)
None
None
 1.00A 6ectA-4uhmA:
undetectable		 6ectA-4uhmA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x6k ANHYDROSIALIDASE

([Ruminococcus]
gnavus) 		PF13088
(BNR_2) 		5 LEU A 705
GLY A 279
ASP A 319
SER A 285
ILE A 287
 None
 1.05A 6ectA-4x6kA:
undetectable		 6ectA-4x6kA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zas CALS13

(Micromonospora
echinospora) 		PF01041
(DegT_DnrJ_EryC1) 		5 ASN A 254
GLY A 209
PHE A 211
GLU A  44
ILE A 260
 None
 1.06A 6ectA-4zasA:
2.1		 6ectA-4zasA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by7 3-OXOACYL-ACP
SYNTHASE III

(Verrucosispora
maris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A 247
GLY A 316
GLY A 304
VAL A 108
LEU A 111
 None
 1.00A 6ectA-5by7A:
undetectable		 6ectA-5by7A:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d2e MLNE

(Bacillus
velezensis) 		PF08659
(KR) 		5 GLY A 387
ILE A 357
GLU A 339
LEU A 343
ILE A 344
 None
None
PG4  A 603 (-3.9A)
PG4  A 603 ( 4.5A)
None
 1.06A 6ectA-5d2eA:
3.2		 6ectA-5d2eA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE

(Homo sapiens) 		PF03291
(Pox_MCEL) 		6 GLY A 205
GLY A 207
ASP A 211
ILE A 228
SER A 262
VAL A 286
 SAH  A 501 (-3.4A)
SAH  A 501 (-3.4A)
SAH  A 501 ( 4.1A)
SAH  A 501 (-3.8A)
SAH  A 501 (-4.0A)
SAH  A 501 (-4.2A)
 0.60A 6ectA-5e9jA:
14.3		 6ectA-5e9jA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9w MRNA CAP GUANINE-N7
METHYLTRANSFERASE

(Homo sapiens) 		PF03291
(Pox_MCEL) 		6 GLY A 205
GLY A 207
ASP A 211
ILE A 228
SER A 262
VAL A 286
 SAH  A 500 (-3.8A)
SAH  A 500 (-3.5A)
SAH  A 500 ( 4.0A)
SAH  A 500 (-3.7A)
SAH  A 500 (-4.1A)
SAH  A 500 (-3.8A)
 0.57A 6ectA-5e9wA:
14.5		 6ectA-5e9wA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evj ARSENITE
METHYLTRANSFERASE

(Chlamydomonas
reinhardtii) 		PF13847
(Methyltransf_31) 		5 GLY A  91
GLY A  93
ASP A  97
VAL A 171
LEU A 174
 None
 0.90A 6ectA-5evjA:
14.0		 6ectA-5evjA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai TAIL FIBER PROTEIN

(Salmonella
virus P22) 		no annotation 5 GLY Y 441
GLY Y 463
ILE Y 454
VAL Y 434
LEU Y 433
 None
 1.00A 6ectA-5gaiY:
undetectable		 6ectA-5gaiY:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT DELTA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		5 LEU d 308
ILE d 241
VAL d 312
LEU d 286
ILE d 288
 None
 1.05A 6ectA-5gw5d:
undetectable		 6ectA-5gw5d:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ASN A1561
GLY A1621
ILE A1557
GLU A1311
LEU A1602
 None
 1.06A 6ectA-5i8iA:
undetectable		 6ectA-5i8iA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyd SHORT CHAIN
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		5 GLY A  80
GLU A 110
VAL A 111
LEU A 114
ILE A 115
 NAD  A 901 (-3.0A)
IOD  A 908 ( 4.4A)
None
None
None
 0.77A 6ectA-5jydA:
4.8		 6ectA-5jydA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		6 LEU B1756
GLY B1853
GLY B1760
ILE B1763
PHE B1879
LEU B1856
 None
 1.29A 6ectA-5k8dB:
undetectable		 6ectA-5k8dB:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxj L-ASPARTATE OXIDASE

(Salmonella
enterica) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 GLY A 222
GLY A 224
VAL A 496
LEU A 499
ILE A 500
 None
 0.83A 6ectA-5kxjA:
undetectable		 6ectA-5kxjA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncr TYROSINE PHOSPHATASE

(Orf virus) 		PF00782
(DSPc) 		5 LEU A 162
GLY A 115
GLY A 120
ASP A  81
GLU A 163
 None
PO4  A 200 (-3.4A)
None
PO4  A 200 (-3.8A)
None
 1.06A 6ectA-5ncrA:
undetectable		 6ectA-5ncrA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osh VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29

(Homo sapiens) 		no annotation 5 LEU A  40
GLY A  61
GLY A  38
PHE A  63
GLU A  65
 None
 0.95A 6ectA-5oshA:
undetectable		 6ectA-5oshA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnu DNA-DEPENDENT ATPASE
XPBII

(Sulfurisphaera
tokodaii) 		no annotation 5 LEU A 199
PHE A 173
VAL A 115
LEU A 120
ILE A 121
 None
 1.04A 6ectA-5tnuA:
3.4		 6ectA-5tnuA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc5 CHS2 CHALCONE
SYNTHASE

(Malus domestica) 		no annotation 5 LEU A 268
ASP A 207
VAL A 271
LEU A 274
ILE A 275
 None
 1.05A 6ectA-5uc5A:
undetectable		 6ectA-5uc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whs CATALASE-PEROXIDASE

(Neurospora
crassa) 		no annotation 5 LEU A 148
GLY A 106
GLY A 108
ASP A 172
LEU A 424
 None
 1.06A 6ectA-5whsA:
undetectable		 6ectA-5whsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ya1 AUTOINDUCER-2 KINASE

(Escherichia
coli) 		no annotation 5 LEU A 272
GLY A 429
GLY A 427
ILE A 449
LEU A 439
 HEZ  A 703 ( 4.3A)
ATP  A 701 ( 3.8A)
None
None
None
 1.02A 6ectA-5ya1A:
undetectable		 6ectA-5ya1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 422
GLY A 266
ILE A 428
VAL A 415
ILE A 412
 None
 1.07A 6ectA-5yk2A:
undetectable		 6ectA-5yk2A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ypt STILBENECARBOXYLATE
SYNTHASE 1

(Marchantia
polymorpha) 		no annotation 5 LEU A 270
ASP A 209
VAL A 273
LEU A 276
ILE A 277
 None
 1.04A 6ectA-5yptA:
undetectable		 6ectA-5yptA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blj SERINE-TRNA LIGASE

(Naegleria
fowleri) 		no annotation 5 LEU A 140
GLY A 143
ILE A  18
SER A  21
LEU A  31
 None
 1.05A 6ectA-6bljA:
undetectable		 6ectA-6bljA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (ALPHA
SUBUNIT)

(Klebsiella
aerogenes) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 THR C 267
ARG C 518
THR C 133
ASP C 360
 None
 1.31A 6ectA-1a5lC:
0.0		 6ectA-1a5lC:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 THR A 310
THR A 148
GLN A  97
ASP A 150
 None
 1.46A 6ectA-1bf2A:
0.0		 6ectA-1bf2A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1chk CHITOSANASE

(Streptomyces
sp. N174) 		PF01374
(Glyco_hydro_46) 		4 THR A  45
ARG A  42
GLN A 114
ASP A  27
 None
 1.49A 6ectA-1chkA:
undetectable		 6ectA-1chkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT BETA

(Helicobacter
pylori) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 THR B 269
ARG B 520
THR B 135
ASP B 362
 None
None
None
HAE  B 800 ( 2.5A)
 1.32A 6ectA-1e9yB:
1.3		 6ectA-1e9yB:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2o TRANSALDOLASE B

(Escherichia
coli) 		PF00923
(TAL_FSA) 		4 THR A  34
THR A  74
GLN A 306
ASP A  72
 None
 1.06A 6ectA-1i2oA:
0.0		 6ectA-1i2oA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n3s GTP CYCLOHYDROLASE I

(Escherichia
coli) 		PF01227
(GTP_cyclohydroI) 		4 THR A 109
THR A 105
GLN A 142
ASP A 103
 None
 1.42A 6ectA-1n3sA:
undetectable		 6ectA-1n3sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n3s GTP CYCLOHYDROLASE I

(Escherichia
coli) 		PF01227
(GTP_cyclohydroI) 		4 THR A 116
THR A 105
GLN A 142
ASP A 103
 None
 1.35A 6ectA-1n3sA:
undetectable		 6ectA-1n3sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
LYSOSOMAL
ALPHA-MANNOSIDASE
LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus;
Bos taurus;
Bos taurus) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid)
PF07748
(Glyco_hydro_38C) 		4 THR A 173
ARG E 916
THR A 163
GLN C 444
 None
 1.50A 6ectA-1o7dA:
0.4		 6ectA-1o7dA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcy RUSTICYANIN

(Acidithiobacillus
ferrooxidans) 		PF00127
(Copper-bind) 		4 THR A  75
THR A  11
GLN A  14
ASP A 117
 None
 1.48A 6ectA-1rcyA:
undetectable		 6ectA-1rcyA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t98 CHROMOSOME PARTITION
PROTEIN MUKF

(Escherichia
coli) 		PF03882
(KicB)
PF17192
(MukF_M) 		4 THR A 174
ARG A 124
GLN A 219
ASP A 227
 None
 1.49A 6ectA-1t98A:
undetectable		 6ectA-1t98A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 THR A 387
ARG A 458
THR A 434
ASP A 465
 None
 1.19A 6ectA-1xkwA:
undetectable		 6ectA-1xkwA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cc0 ACETYL-XYLAN
ESTERASE

(Streptomyces
lividans) 		PF01522
(Polysacc_deac_1) 		4 THR A  10
ARG A 100
THR A  19
GLN A  52
 None
 1.42A 6ectA-2cc0A:
undetectable		 6ectA-2cc0A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kts HEAT SHOCK PROTEIN
HSLJ

(Escherichia
coli) 		PF03724
(META) 		4 THR A 100
THR A  81
GLN A 106
ASP A  79
 None
 1.45A 6ectA-2ktsA:
undetectable		 6ectA-2ktsA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2omv INTERNALIN-A

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		4 THR A 148
ARG A 168
THR A  80
GLN A  82
 None
 1.39A 6ectA-2omvA:
undetectable		 6ectA-2omvA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p82 CYSTEINE PROTEASE
ATG4A

(Homo sapiens) 		PF03416
(Peptidase_C54) 		4 THR A 299
ARG A  58
THR A 294
GLN A 112
 None
 1.10A 6ectA-2p82A:
undetectable		 6ectA-2p82A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg3 QUEUOSINE
BIOSYNTHESIS PROTEIN
QUEC

(Pectobacterium
atrosepticum) 		PF06508
(QueC) 		4 THR A 185
ARG A 206
GLN A 177
ASP A  24
 None
 1.40A 6ectA-2pg3A:
undetectable		 6ectA-2pg3A:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pny ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
2

(Homo sapiens) 		PF00293
(NUDIX) 		4 ARG A 110
THR A 168
GLN A  68
ASP A  72
 None
 1.15A 6ectA-2pnyA:
undetectable		 6ectA-2pnyA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3das PUTATIVE
OXIDOREDUCTASE

(Streptomyces
coelicolor) 		PF07995
(GSDH) 		4 THR A 312
ARG A 144
THR A 328
ASP A 333
 None
 1.44A 6ectA-3dasA:
undetectable		 6ectA-3dasA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euf URIDINE
PHOSPHORYLASE 1

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		4 THR A 141
THR A 210
GLN A 217
ASP A 160
 PO4  A 401 ( 3.0A)
None
BAU  A 400 (-3.1A)
None
 1.32A 6ectA-3eufA:
undetectable		 6ectA-3eufA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euf URIDINE
PHOSPHORYLASE 1

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		4 THR A 271
THR A 210
GLN A 217
ASP A 160
 None
None
BAU  A 400 (-3.1A)
None
 1.45A 6ectA-3eufA:
undetectable		 6ectA-3eufA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvy URIDINE
PHOSPHORYLASE

(Bos taurus) 		PF01048
(PNP_UDP_1) 		4 THR A 140
THR A 209
GLN A 216
ASP A 159
 SO4  A 311 ( 3.1A)
None
URA  A 312 (-3.3A)
None
 1.38A 6ectA-3kvyA:
undetectable		 6ectA-3kvyA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0f URIDINE
PHOSPHORYLASE 2

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		4 THR A 147
THR A 216
GLN A 223
ASP A 166
 BAU  A 400 (-4.5A)
None
BAU  A 400 (-3.1A)
None
 1.38A 6ectA-3p0fA:
undetectable		 6ectA-3p0fA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0f URIDINE
PHOSPHORYLASE 2

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		4 THR A 277
THR A 216
GLN A 223
ASP A 166
 None
None
BAU  A 400 (-3.1A)
None
 1.46A 6ectA-3p0fA:
undetectable		 6ectA-3p0fA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vta CUCUMISIN

(Cucumis melo) 		PF00082
(Peptidase_S8) 		4 THR A 112
ARG A 332
THR A 208
ASP A 200
 None
 1.48A 6ectA-3vtaA:
undetectable		 6ectA-3vtaA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7o SERINE
ACETYLTRANSFERASE

(Vibrio cholerae) 		PF00132
(Hexapep)
PF06426
(SATase_N) 		4 THR A 167
ARG A 192
THR A 130
GLN A 133
 None
CYS  A 301 (-3.8A)
None
None
 1.37A 6ectA-4h7oA:
undetectable		 6ectA-4h7oA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqt PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF06439
(DUF1080) 		4 THR A 216
ARG A 161
GLN A  20
ASP A 203
 None
EDO  A 505 ( 3.6A)
None
None
 1.30A 6ectA-4jqtA:
undetectable		 6ectA-4jqtA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh3 ANTIGEN 43

(Escherichia
coli) 		PF16168
(AIDA) 		4 THR A 163
THR A  97
GLN A 105
ASP A  79
 None
 1.24A 6ectA-4kh3A:
undetectable		 6ectA-4kh3A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mae METHANOL
DEHYDROGENASE

(Methylacidiphilum
fumariolicum) 		PF13360
(PQQ_2) 		4 THR A 222
THR A 275
GLN A 291
ASP A 301
 None
None
None
CE  A 601 ( 2.3A)
 1.43A 6ectA-4maeA:
undetectable		 6ectA-4maeA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nge PRESEQUENCE
PROTEASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 ARG D 924
THR D 139
GLN D 107
ASP D 142
 None
 1.45A 6ectA-4ngeD:
undetectable		 6ectA-4ngeD:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1q ADHESIN/INVASIN TIBA
AUTOTRANSPORTER

(Escherichia
coli) 		PF16168
(AIDA) 		4 THR A 139
THR A  82
GLN A  90
ASP A  58
 None
 1.27A 6ectA-4q1qA:
undetectable		 6ectA-4q1qA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry1 PERIPLASMIC SOLUTE
BINDING PROTEIN

(Pectobacterium
atrosepticum) 		PF13416
(SBP_bac_8) 		4 THR A 201
THR A 301
GLN A 209
ASP A 167
 None
None
GOL  A 503 ( 4.6A)
None
 1.44A 6ectA-4ry1A:
undetectable		 6ectA-4ry1A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvc DEXTRANSUCRASE

(Leuconostoc
mesenteroides) 		PF02324
(Glyco_hydro_70) 		4 ARG A2539
THR A2514
GLN A2533
ASP A2510
 None
 1.50A 6ectA-4tvcA:
undetectable		 6ectA-4tvcA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es6 LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A

(Brevibacillus
parabrevis) 		PF00501
(AMP-binding)
PF00551
(Formyl_trans_N) 		4 ARG A 376
THR A 204
GLN A 207
ASP A 343
 None
 1.33A 6ectA-5es6A:
1.9		 6ectA-5es6A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL

(Oryctolagus
cuniculus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 THR A 202
ARG A 144
THR A 168
ASP A 171
 None
 1.40A 6ectA-5h53A:
undetectable		 6ectA-5h53A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		4 THR A  96
ARG A 148
GLN A 439
ASP A 178
 None
 1.34A 6ectA-5hm5A:
undetectable		 6ectA-5hm5A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huu ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
[UDP-FORMING]

(Candida
albicans) 		PF00982
(Glyco_transf_20) 		4 THR A 330
THR A 377
GLN A 289
ASP A 379
 None
None
None
UDP  A 501 ( 4.9A)
 1.16A 6ectA-5huuA:
undetectable		 6ectA-5huuA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		4 THR A 466
THR A 288
GLN A 500
ASP A 286
 None
 1.35A 6ectA-5i6vA:
undetectable		 6ectA-5i6vA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jh8 PROBABLE CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18) 		4 ARG A 275
THR A 235
GLN A 236
ASP A 220
 None
 1.21A 6ectA-5jh8A:
undetectable		 6ectA-5jh8A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnm MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE

(Staphylococcus
aureus) 		no annotation 4 THR A 206
THR A 248
GLN A 258
ASP A 252
 None
 1.43A 6ectA-5jnmA:
3.7		 6ectA-5jnmA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz9 -

(-) 		no annotation 4 THR A 365
THR A 420
GLN A 492
ASP A 422
 None
 1.38A 6ectA-5mz9A:
undetectable		 6ectA-5mz9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odw PYOCIN-S2

(Pseudomonas
aeruginosa) 		no annotation 4 THR C  14
THR C  76
GLN C 175
ASP C  81
 None
 1.41A 6ectA-5odwC:
undetectable		 6ectA-5odwC:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uam ULVAN LYASE-PL25

(Pseudoalteromonas
sp. PLSV) 		PF15892
(BNR_4) 		4 THR A 187
ARG A 204
GLN A 146
ASP A 115
 PO4  A 503 ( 4.9A)
PO4  A 503 ( 3.0A)
None
None
 1.48A 6ectA-5uamA:
undetectable		 6ectA-5uamA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysx -

(-) 		no annotation 4 THR A  83
THR A 163
GLN A 117
ASP A 160
 None
 1.14A 6ectA-5ysxA:
undetectable		 6ectA-5ysxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens) 		no annotation 4 THR A 597
THR A 175
GLN A 239
ASP A 544
 None
 1.42A 6ectA-5zl9A:
undetectable		 6ectA-5zl9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6axe MALATE SYNTHASE G

(Mycobacterium
marinum) 		PF01274
(Malate_synthase) 		4 THR A  56
THR A  47
GLN A  51
ASP A  45
 None
 1.46A 6ectA-6axeA:
undetectable		 6ectA-6axeA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfi VIN1

(Oscarella
pearsei) 		no annotation 4 THR A 806
THR A 754
GLN A 758
ASP A 749
 None
 1.35A 6ectA-6bfiA:
undetectable		 6ectA-6bfiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c3b UNCHARACTERIZED
PROTEIN

(Streptomyces
cattleya) 		no annotation 4 THR A 296
THR A  35
GLN A  37
ASP A  32
 None
LLP  A 235 ( 4.4A)
None
None
 1.37A 6ectA-6c3bA:
3.5		 6ectA-6c3bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-2,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT BETA-2
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
GAMMA-2,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT GAMMA-2

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 THR A 123
THR E 216
GLN A  64
ASP E 219
 None
 1.30A 6ectA-6d6uA:
undetectable		 6ectA-6d6uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6y APRA
METHYLTRANSFERASE 2

(Moorea
bouillonii) 		no annotation 4 THR A 786
ARG A 765
THR A 840
ASP A 864
 None
None
SAH  A1102 (-4.1A)
SAH  A1102 (-2.4A)
 1.40A 6ectA-6d6yA:
14.3		 6ectA-6d6yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dd6 PHOTOLYASE PHRB

(Agrobacterium
tumefaciens) 		no annotation 4 ARG A 108
THR A 102
GLN A  11
ASP A 125
 DLZ  A 602 ( 4.8A)
None
None
None
 1.48A 6ectA-6dd6A:
undetectable		 6ectA-6dd6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dw1


(;
) 		no annotation
no annotation 		4 THR E 123
THR D 216
GLN E  64
ASP D 219
 None
 1.35A 6ectA-6dw1E:
undetectable		 6ectA-6dw1E:
undetectable