SIMILAR PATTERNS OF AMINO ACIDS FOR 6ECE_C_DVAC3010_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwz PROTEIN
(DIAMINOPIMELATE
EPIMERASE)

(Haemophilus
influenzae) 		PF01678
(DAP_epimerase) 		3 ALA A  77
PHE A  13
GLN A  44
 None
 0.81A 6eceA-1bwzA:
undetectable		 6eceA-1bwzA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.) 		PF00067
(p450) 		3 ALA A 323
PHE A  70
GLN A  66
 None
 0.70A 6eceA-1cptA:
undetectable		 6eceA-1cptA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanopyrus
kandleri) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		3 ALA B 305
PHE B 389
GLN B 221
 None
 0.76A 6eceA-1e6vB:
undetectable		 6eceA-1e6vB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanosarcina
barkeri) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		3 ALA B2302
PHE B2386
GLN B2217
 None
 0.72A 6eceA-1e6yB:
undetectable		 6eceA-1e6yB:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4h BETA-GALACTOSIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 ALA A 616
PHE A 549
GLN A 624
 None
 0.76A 6eceA-1f4hA:
undetectable		 6eceA-1f4hA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE

(Pyrococcus
horikoshii) 		PF00857
(Isochorismatase) 		3 ALA A  20
PHE A  15
GLN A  12
 None
 0.73A 6eceA-1im5A:
undetectable		 6eceA-1im5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ks5 ENDOGLUCANASE A

(Aspergillus
niger) 		PF01670
(Glyco_hydro_12) 		3 ALA A 109
PHE A 101
GLN A 158
 None
 0.80A 6eceA-1ks5A:
undetectable		 6eceA-1ks5A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l9y FEZ-1 B-LACTAMASE

(Fluoribacter
gormanii) 		PF00753
(Lactamase_B) 		3 ALA A  97
PHE A 106
GLN A 131
 None
 0.79A 6eceA-1l9yA:
undetectable		 6eceA-1l9yA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ljy MGP-40

(Capra hircus) 		PF00704
(Glyco_hydro_18) 		3 ALA A 216
PHE A 202
GLN A 294
 None
 0.83A 6eceA-1ljyA:
2.5		 6eceA-1ljyA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE

(Homo sapiens) 		PF02574
(S-methyl_trans) 		3 ALA A 103
PHE A 148
GLN A 144
 None
 0.82A 6eceA-1lt8A:
2.6		 6eceA-1lt8A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npe NIDOGEN

(Mus musculus) 		PF00058
(Ldl_recept_b) 		3 ALA A 939
PHE A 918
GLN A 920
 None
 0.81A 6eceA-1npeA:
undetectable		 6eceA-1npeA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 ALA A 856
PHE A 928
GLN A 903
 None
 0.82A 6eceA-1rjbA:
undetectable		 6eceA-1rjbA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyo NALP

(Neisseria
meningitidis) 		PF03797
(Autotransporter) 		3 ALA X 807
PHE X 886
GLN X 801
 None
 0.73A 6eceA-1uyoX:
undetectable		 6eceA-1uyoX:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii) 		PF02310
(B12-binding)
PF16554
(OAM_dimer) 		3 ALA B  51
PHE B  79
GLN B  69
 None
 0.79A 6eceA-1xrsB:
3.1		 6eceA-1xrsB:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2as0 HYPOTHETICAL PROTEIN
PH1915

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF10672
(Methyltrans_SAM) 		3 ALA A 210
PHE A 231
GLN A 204
 None
 0.61A 6eceA-2as0A:
undetectable		 6eceA-2as0A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avt DNA POLYMERASE III
BETA SUBUNIT

(Streptococcus
pyogenes) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		3 ALA A 147
PHE A 151
GLN A 370
 None
 0.82A 6eceA-2avtA:
undetectable		 6eceA-2avtA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b18 GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY

(Bacillus
subtilis) 		PF06018
(CodY) 		3 ALA A 108
PHE A  98
GLN A  55
 None
 0.74A 6eceA-2b18A:
undetectable		 6eceA-2b18A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b81 LUCIFERASE-LIKE
MONOOXYGENASE

(Bacillus cereus) 		PF00296
(Bac_luciferase) 		3 ALA A 227
PHE A 246
GLN A 248
 None
 0.68A 6eceA-2b81A:
undetectable		 6eceA-2b81A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Desulfovibrio
africanus) 		PF01558
(POR)
PF01855
(POR_N)
PF02775
(TPP_enzyme_C)
PF10371
(EKR)
PF13484
(Fer4_16)
PF17147
(PFOR_II) 		3 ALA A 571
PHE A 568
GLN A 564
 None
 0.82A 6eceA-2c3oA:
4.3		 6eceA-2c3oA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d40 PUTATIVE GENTISATE
1,2-DIOXYGENASE

(Escherichia
coli) 		PF07883
(Cupin_2) 		3 ALA A 272
PHE A 314
GLN A 261
 None
 0.71A 6eceA-2d40A:
undetectable		 6eceA-2d40A:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		3 ALA A 274
PHE A 290
GLN A 131
 None
 0.83A 6eceA-2f9qA:
undetectable		 6eceA-2f9qA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy8 PROTEIN PM0188

(Pasteurella
multocida) 		PF11477
(PM0188) 		3 ALA A 333
PHE A 308
GLN A 284
 None
 0.76A 6eceA-2iy8A:
undetectable		 6eceA-2iy8A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l73 NADPH OXIDASE
ORGANIZER 1

(Homo sapiens) 		PF00787
(PX) 		3 ALA A  90
PHE A  24
GLN A  22
 None
 0.84A 6eceA-2l73A:
undetectable		 6eceA-2l73A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn3 CASPASE-1

(Spodoptera
frugiperda) 		PF00656
(Peptidase_C14) 		3 ALA C 268
PHE C 264
GLN C 279
 None
 0.77A 6eceA-2nn3C:
3.3		 6eceA-2nn3C:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		3 ALA A  35
PHE A 160
GLN A 191
 None
 0.80A 6eceA-2np0A:
undetectable		 6eceA-2np0A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozj CUPIN 2, CONSERVED
BARREL

(Desulfitobacterium
hafniense) 		no annotation 3 ALA A  30
PHE A  42
GLN A 105
 None
 0.65A 6eceA-2ozjA:
undetectable		 6eceA-2ozjA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9w MAL S 1 ALLERGENIC
PROTEIN

(Malassezia
sympodialis) 		no annotation 3 ALA A 177
PHE A 159
GLN A 116
 None
 0.74A 6eceA-2p9wA:
undetectable		 6eceA-2p9wA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF16073
(SAT) 		3 ALA B 424
PHE B 427
GLN B 275
 None
 0.66A 6eceA-2pffB:
3.4		 6eceA-2pffB:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plj LYSINE/ORNITHINE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		3 ALA A  55
PHE A 274
GLN A  48
 None
 0.84A 6eceA-2pljA:
2.6		 6eceA-2pljA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3s UNCHARACTERIZED
PROTEIN

(Nostoc
punctiforme) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		3 ALA A 285
PHE A 271
GLN A 326
 None
None
EDO  A 340 (-4.3A)
 0.66A 6eceA-2r3sA:
3.3		 6eceA-2r3sA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rae TRANSCRIPTIONAL
REGULATOR, ACRR
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		3 ALA A 102
PHE A 100
GLN A  79
 None
 0.82A 6eceA-2raeA:
undetectable		 6eceA-2raeA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		3 ALA G 424
PHE G 427
GLN G 275
 None
 0.69A 6eceA-2uv8G:
0.2		 6eceA-2uv8G:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ver AFIMBRIAL ADHESIN
AFA-III

(Escherichia
coli) 		PF04619
(Adhesin_Dr) 		3 ALA A  44
PHE A 129
GLN A 127
 None
 0.82A 6eceA-2verA:
undetectable		 6eceA-2verA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6d DYNAMIN FAMILY
PROTEIN

(Nostoc
punctiforme) 		PF00350
(Dynamin_N) 		3 ALA A 163
PHE A 121
GLN A 128
 None
 0.83A 6eceA-2w6dA:
2.3		 6eceA-2w6dA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wcv L-FUCOSE MUTAROTASE

(Escherichia
coli) 		PF05025
(RbsD_FucU) 		3 ALA A  18
PHE A 118
GLN A  41
 None
 0.81A 6eceA-2wcvA:
undetectable		 6eceA-2wcvA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhg CELLULOSE-BINDING
PROTEIN

(Saccharophagus
degradans) 		PF07632
(DUF1593) 		3 ALA A 654
PHE A 695
GLN A 661
 None
 0.77A 6eceA-2yhgA:
undetectable		 6eceA-2yhgA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		3 ALA A 164
PHE A 485
GLN A 481
 None
 0.67A 6eceA-3ahiA:
undetectable		 6eceA-3ahiA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		3 ALA A 164
PHE A 485
GLN A 481
 None
 0.64A 6eceA-3ai7A:
undetectable		 6eceA-3ai7A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b32 CALMODULIN

(Rattus
norvegicus) 		PF13499
(EF-hand_7) 		3 ALA A  73
PHE A  12
GLN A   8
 None
 0.82A 6eceA-3b32A:
undetectable		 6eceA-3b32A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwh CUCURMOSIN

(Cucurbita
moschata) 		PF00161
(RIP) 		3 ALA A  63
PHE A  82
GLN A 100
 None
 0.83A 6eceA-3bwhA:
undetectable		 6eceA-3bwhA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0k UPF0064 PROTEIN YCCW

(Escherichia
coli) 		PF10672
(Methyltrans_SAM) 		3 ALA A 214
PHE A 234
GLN A 208
 None
 0.83A 6eceA-3c0kA:
2.4		 6eceA-3c0kA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh4 SODIUM/GLUCOSE
COTRANSPORTER

(Vibrio
parahaemolyticus) 		PF00474
(SSF) 		3 ALA A 259
PHE A 479
GLN A 425
 GAL  A 701 ( 4.0A)
None
None
 0.82A 6eceA-3dh4A:
undetectable		 6eceA-3dh4A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evn OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Streptococcus
agalactiae) 		PF01408
(GFO_IDH_MocA) 		3 ALA A 156
PHE A 228
GLN A 212
 None
 0.75A 6eceA-3evnA:
undetectable		 6eceA-3evnA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd6 AMMONIUM TRANSPORTER
RH TYPE C

(Homo sapiens) 		PF00909
(Ammonium_transp) 		3 ALA A 133
PHE A 162
GLN A 107
 None
 0.62A 6eceA-3hd6A:
undetectable		 6eceA-3hd6A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm0 PROBABLE
THIOESTERASE

(Bartonella
henselae) 		PF03061
(4HBT) 		3 ALA A 125
PHE A 105
GLN A 100
 None
 0.84A 6eceA-3hm0A:
undetectable		 6eceA-3hm0A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrr AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE

(Aspergillus
parasiticus) 		PF14765
(PS-DH) 		3 ALA A1516
PHE A1483
GLN A1482
 None
 0.65A 6eceA-3hrrA:
undetectable		 6eceA-3hrrA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3io3 DEHA2D07832P

(Debaryomyces
hansenii) 		PF02374
(ArsA_ATPase) 		3 ALA A  74
PHE A  70
GLN A  68
 None
 0.80A 6eceA-3io3A:
3.3		 6eceA-3io3A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3irv CYSTEINE HYDROLASE

(Pseudomonas
savastanoi) 		PF00857
(Isochorismatase) 		3 ALA A  67
PHE A  61
GLN A  58
 None
 0.68A 6eceA-3irvA:
3.2		 6eceA-3irvA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0o RIBOSOMAL PROTEIN
S23

(Oryctolagus
cuniculus) 		PF00164
(Ribosom_S12_S23) 		3 ALA L  48
PHE L 121
GLN L 109
 None
 0.68A 6eceA-3j0oL:
undetectable		 6eceA-3j0oL:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j8f POLIOVIRUS RECEPTOR

(Homo sapiens) 		PF07686
(V-set)
PF08205
(C2-set_2) 		3 ALA 7 175
PHE 7 228
GLN 7 232
 None
 0.71A 6eceA-3j8f7:
undetectable		 6eceA-3j8f7:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9f POLIOVIRUS RECEPTOR

(Homo sapiens) 		PF08205
(C2-set_2) 		3 ALA 8 175
PHE 8 228
GLN 8 232
 None
 0.72A 6eceA-3j9f8:
undetectable		 6eceA-3j9f8:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6d PUTATIVE
OXIDOREDUCTASE

(Pseudomonas
putida) 		PF03446
(NAD_binding_2) 		3 ALA A 226
PHE A 235
GLN A 233
 None
 0.73A 6eceA-3l6dA:
2.5		 6eceA-3l6dA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA

(Methanothermobacter
marburgensis) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		3 ALA B 304
PHE B 388
GLN B 220
 None
 0.74A 6eceA-3m2rB:
undetectable		 6eceA-3m2rB:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkh NITROALKANE OXIDASE

(Podospora
anserina) 		PF00441
(Acyl-CoA_dh_1)
PF02771
(Acyl-CoA_dh_N) 		3 ALA A 329
PHE A 358
GLN A 323
 None
 0.81A 6eceA-3mkhA:
undetectable		 6eceA-3mkhA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o65 PUTATIVE
ATAXIN-3-LIKE
PROTEIN

(Homo sapiens) 		PF02099
(Josephin) 		3 ALA A 150
PHE A  95
GLN A 101
 None
 0.84A 6eceA-3o65A:
undetectable		 6eceA-3o65A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o65 PUTATIVE
ATAXIN-3-LIKE
PROTEIN

(Homo sapiens) 		PF02099
(Josephin) 		3 ALA A 154
PHE A  95
GLN A 101
 None
 0.74A 6eceA-3o65A:
undetectable		 6eceA-3o65A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdo NITRILOTRIACETATE
MONOOXYGENASE

(Burkholderia
pseudomallei) 		PF00296
(Bac_luciferase) 		3 ALA A 151
PHE A 193
GLN A 145
 None
 0.83A 6eceA-3sdoA:
undetectable		 6eceA-3sdoA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3som METHYLMALONIC
ACIDURIA AND
HOMOCYSTINURIA TYPE
C PROTEIN

(Homo sapiens) 		PF16690
(MMACHC) 		3 ALA A  57
PHE A 154
GLN A 212
 None
 0.81A 6eceA-3somA:
undetectable		 6eceA-3somA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3td9 BRANCHED CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Thermotoga
maritima) 		PF13458
(Peripla_BP_6) 		3 ALA A 116
PHE A 134
GLN A 139
 PHE  A 400 (-3.6A)
None
None
 0.81A 6eceA-3td9A:
3.1		 6eceA-3td9A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4a JMB19063

(compost
metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 ALA A 325
PHE A 170
GLN A 166
 None
 0.72A 6eceA-3u4aA:
3.6		 6eceA-3u4aA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ud2 ANKYRIN-1

(Homo sapiens) 		no annotation 3 ALA C1220
PHE C1225
GLN C1125
 None
 0.77A 6eceA-3ud2C:
undetectable		 6eceA-3ud2C:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujz METALLOPROTEASE STCE

(Escherichia
coli) 		PF10462
(Peptidase_M66) 		3 ALA A 549
PHE A 551
GLN A 408
 None
 0.81A 6eceA-3ujzA:
undetectable		 6eceA-3ujzA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usz EXO-1,3/1,4-BETA-GLU
CANASE

(Pseudoalteromonas
sp. BB1) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		3 ALA A 327
PHE A 325
GLN A  53
 None
 0.75A 6eceA-3uszA:
undetectable		 6eceA-3uszA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr1 PEPTIDE CHAIN
RELEASE FACTOR 3

(Desulfovibrio
vulgaris) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF16658
(RF3_C) 		3 ALA A 499
PHE A 427
GLN A 425
 None
 0.69A 6eceA-3vr1A:
2.7		 6eceA-3vr1A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		3 ALA A 646
PHE A 324
GLN A 326
 None
 0.72A 6eceA-3welA:
undetectable		 6eceA-3welA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wib HALOALKANE
DEHALOGENASE

(Agrobacterium
fabrum) 		PF00561
(Abhydrolase_1) 		3 ALA A 227
PHE A 223
GLN A  87
 None
 0.84A 6eceA-3wibA:
16.5		 6eceA-3wibA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0k CULLIN-4A

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		3 ALA A 406
PHE A 452
GLN A 681
 None
 0.79A 6eceA-4a0kA:
undetectable		 6eceA-4a0kA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agh MOSUB1,
TRANSCRIPTION
COFACTOR

(Magnaporthe
oryzae) 		PF02229
(PC4) 		3 ALA A  43
PHE A  48
GLN A  40
 None
 0.78A 6eceA-4aghA:
undetectable		 6eceA-4aghA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 ALA B2386
PHE B2433
GLN B2255
 None
 0.63A 6eceA-4bedB:
undetectable		 6eceA-4bedB:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE

(Brevibacillus
brevis) 		PF03306
(AAL_decarboxy) 		3 ALA A  94
PHE A  26
GLN A 229
 None
 0.74A 6eceA-4bt6A:
undetectable		 6eceA-4bt6A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eoc PHYCOCYANOBILIN:FERR
EDOXIN
OXIDOREDUCTASE

(Synechocystis
sp. PCC 6803) 		PF05996
(Fe_bilin_red) 		3 ALA A 118
PHE A 158
GLN A 216
 None
BLA  A1001 (-4.4A)
BLA  A1001 (-3.5A)
 0.81A 6eceA-4eocA:
undetectable		 6eceA-4eocA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmt CHPT PROTEIN

(Caulobacter
vibrioides) 		PF10090
(HPTransfase) 		3 ALA A 153
PHE A 157
GLN A 119
 None
 0.79A 6eceA-4fmtA:
undetectable		 6eceA-4fmtA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1l TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27) 		3 ALA A  36
PHE A 160
GLN A 195
 None
 0.81A 6eceA-4j1lA:
undetectable		 6eceA-4j1lA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgt 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE

(Homo sapiens) 		PF00581
(Rhodanese) 		3 ALA A 185
PHE A 213
GLN A 105
 None
 0.75A 6eceA-4jgtA:
2.5		 6eceA-4jgtA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k61 UNCHARACTERIZED
PROTEIN

(Bacteroides
uniformis) 		PF11396
(PepSY_like) 		3 ALA A 157
PHE A 159
GLN A  76
 None
 0.83A 6eceA-4k61A:
undetectable		 6eceA-4k61A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfy DIHYDROOROTASE

(Burkholderia
cenocepacia) 		PF01979
(Amidohydro_1) 		3 ALA A 313
PHE A  51
GLN A  50
 None
 0.84A 6eceA-4lfyA:
undetectable		 6eceA-4lfyA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7q LIPOLYTIC PROTEIN
G-D-S-L FAMILY

(Chitinophaga
pinensis) 		PF13472
(Lipase_GDSL_2) 		3 ALA A 179
PHE A 176
GLN A 171
 None
 0.76A 6eceA-4q7qA:
4.4		 6eceA-4q7qA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN

(Salmonella
enterica) 		PF13343
(SBP_bac_6) 		3 ALA A  51
PHE A 269
GLN A  44
 None
 0.79A 6eceA-4r6yA:
undetectable		 6eceA-4r6yA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Actinoplanes
teichomyceticus) 		PF00668
(Condensation) 		3 ALA B  24
PHE B  72
GLN B  81
 None
 0.79A 6eceA-4tx2B:
undetectable		 6eceA-4tx2B:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4

(Homo sapiens) 		PF01421
(Reprolysin) 		3 ALA A 248
PHE A 357
GLN A 354
 None
 0.85A 6eceA-4wk7A:
undetectable		 6eceA-4wk7A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb0 SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00659
(POLO_box) 		3 ALA A 548
PHE A 565
GLN A 564
 None
 0.72A 6eceA-4xb0A:
undetectable		 6eceA-4xb0A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfk PUTATIVE BRANCHED
CHAIN AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Brucella ovis) 		PF13458
(Peripla_BP_6) 		3 ALA A 370
PHE A 424
GLN A 421
 None
 0.69A 6eceA-4xfkA:
2.7		 6eceA-4xfkA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Drosophila
melanogaster) 		PF13191
(AAA_16)
PF14630
(ORC5_C) 		3 ALA E  89
PHE E 121
GLN E 119
 None
 0.84A 6eceA-4xgcE:
undetectable		 6eceA-4xgcE:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y85 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		3 ALA A 183
PHE A 185
GLN A 276
 None
 0.79A 6eceA-4y85A:
undetectable		 6eceA-4y85A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		3 ALA A  61
PHE A  45
GLN A  47
 None
 0.73A 6eceA-4yv7A:
5.1		 6eceA-4yv7A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a1n AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 2

(Homo sapiens) 		PF00043
(GST_C) 		3 ALA B 277
PHE B 218
GLN B 223
 None
GOL  B1321 ( 4.9A)
GOL  B1321 (-3.2A)
 0.82A 6eceA-5a1nB:
undetectable		 6eceA-5a1nB:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus) 		PF01398
(JAB)
PF13012
(MitMem_reg)
PF01399
(PCI) 		3 ALA M 131
PHE F 106
GLN M 138
 None
 0.69A 6eceA-5a5tM:
undetectable		 6eceA-5a5tM:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin) 		3 ALA E  55
PHE E  94
GLN E  60
 None
 0.75A 6eceA-5brrE:
undetectable		 6eceA-5brrE:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9i PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		3 ALA A 430
PHE A 440
GLN A 282
 None
 0.84A 6eceA-5c9iA:
undetectable		 6eceA-5c9iA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		3 ALA A 621
PHE A 619
GLN A 651
 None
 0.76A 6eceA-5dkxA:
undetectable		 6eceA-5dkxA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 ALA A  14
PHE A 197
GLN A 199
 None
 0.75A 6eceA-5f7sA:
undetectable		 6eceA-5f7sA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnc AVH146

(Phytophthora
sojae) 		no annotation 3 ALA A 366
PHE A 353
GLN A 349
 None
 0.82A 6eceA-5gncA:
undetectable		 6eceA-5gncA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipn RNA POLYMERASE SIGMA
FACTOR RPOS

(Escherichia
coli) 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4) 		3 ALA F 285
PHE F 278
GLN F 306
 None
 0.84A 6eceA-5ipnF:
undetectable		 6eceA-5ipnF:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT

(Methanotorris
formicicus) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		3 ALA B 305
PHE B 389
GLN B 220
 None
 0.85A 6eceA-5n28B:
undetectable		 6eceA-5n28B:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u89 AMINO ACID
ADENYLATION DOMAIN
PROTEIN

(Geobacillus sp.
Y4.1MC1) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF13193
(AMP-binding_C) 		3 ALA A1161
PHE A1111
GLN A1060
 None
 0.81A 6eceA-5u89A:
undetectable		 6eceA-5u89A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqk SULFURTRANSFERASE

(Mus musculus) 		PF00581
(Rhodanese) 		3 ALA A 185
PHE A 213
GLN A 105
 None
 0.67A 6eceA-5wqkA:
undetectable		 6eceA-5wqkA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wso NS3 HELICASE

(Pestivirus A) 		no annotation 3 ALA A 311
PHE A 340
GLN A 305
 None
 0.81A 6eceA-5wsoA:
undetectable		 6eceA-5wsoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3j GLYCOSIDE HYDROLASE
FAMILY 31

(Kribbella
flavida) 		no annotation 3 ALA A  14
PHE A 188
GLN A 190
 None
 0.61A 6eceA-5x3jA:
undetectable		 6eceA-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xix ASPARAGINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		no annotation 3 ALA A 161
PHE A 146
GLN A 140
 None
 0.68A 6eceA-5xixA:
undetectable		 6eceA-5xixA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygu DIAMINOPIMELATE
EPIMERASE

(Escherichia
coli) 		no annotation 3 ALA A  77
PHE A  13
GLN A  44
 None
 0.78A 6eceA-5yguA:
undetectable		 6eceA-5yguA:
undetectable