SIMILAR PATTERNS OF AMINO ACIDS FOR 6EBP_C_DAHC123

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jnf SEROTRANSFERRIN

(Oryctolagus
cuniculus) 		PF00405
(Transferrin) 		5 LEU A 293
ASP A 297
SER A 189
GLY A 187
PHE A 186
 None
None
None
CL  A 800 (-3.5A)
None
 1.13A 6ebpC-1jnfA:
undetectable		 6ebpC-1jnfA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 LEU A 540
ASP A 541
GLY A 530
ILE A 528
PHE A 477
 None
 1.09A 6ebpC-1jx2A:
undetectable		 6ebpC-1jx2A:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgp RIBONUCLEOTIDE
REDUCTASE PROTEIN
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		6 LEU A  73
THR A  74
ASP A  77
SER A 114
ILE A 118
ILE A 198
 None
None
MN  A1001 (-2.7A)
None
None
None
 0.67A 6ebpC-1kgpA:
42.3		 6ebpC-1kgpA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgp RIBONUCLEOTIDE
REDUCTASE PROTEIN
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		8 PHE A  70
LEU A  73
THR A  74
ASP A  77
ILE A 118
PHE A 119
PHE A 176
ILE A 198
 None
None
None
MN  A1001 (-2.7A)
None
None
None
None
 0.45A 6ebpC-1kgpA:
42.3		 6ebpC-1kgpA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
MAJOR SUBUNIT

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 PHE A 180
ASP A 649
GLY A 655
ILE A 656
ILE A 582
 None
MGD  A1018 (-2.9A)
None
None
MGD  A1018 (-4.5A)
 1.19A 6ebpC-1kqfA:
undetectable		 6ebpC-1kqfA:
5.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lc0 BILIVERDIN REDUCTASE
A

(Rattus
norvegicus) 		PF01408
(GFO_IDH_MocA)
PF09166
(Biliv-reduc_cat) 		5 LEU A 189
THR A 188
ILE A 215
PHE A 163
ILE A 287
 None
 1.17A 6ebpC-1lc0A:
undetectable		 6ebpC-1lc0A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 PHE A 436
THR A 438
ASP A 442
GLY A 430
ILE A 432
 None
 1.22A 6ebpC-1lpfA:
undetectable		 6ebpC-1lpfA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqt POLYPROTEIN CAPSID
PROTEIN

(Enterovirus B) 		PF00073
(Rhv) 		5 PHE C  85
LEU C  95
THR C  88
GLY C 188
ILE C 114
 None
 1.07A 6ebpC-1mqtC:
undetectable		 6ebpC-1mqtC:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pv5 HYPOTHETICAL PROTEIN
YWQG

(Bacillus
subtilis) 		PF09234
(DUF1963) 		5 THR A 156
ASP A 157
GLY A 190
PHE A 191
PHE A 240
 None
 1.14A 6ebpC-1pv5A:
undetectable		 6ebpC-1pv5A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhl PROTEIN (CELL
DIVISION PROTEIN
MUKB)

(Escherichia
coli) 		PF04310
(MukB) 		5 LEU A  90
THR A  92
GLY A 182
ILE A 184
PHE A  47
 None
 1.16A 6ebpC-1qhlA:
undetectable		 6ebpC-1qhlA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1

(Pinus taeda) 		PF05368
(NmrA) 		5 THR A  84
GLY A  86
ILE A  90
PHE A 109
ILE A  96
 None
 1.22A 6ebpC-1qycA:
undetectable		 6ebpC-1qycA:
14.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r2f PROTEIN
(RIBONUCLEOTIDE
REDUCTASE R2)

(Salmonella
enterica) 		PF00268
(Ribonuc_red_sm) 		7 LEU A  63
THR A  64
ASP A  67
SER A 104
ILE A 108
PHE A 109
ILE A 188
 None
None
FE  A 400 (-3.0A)
None
None
None
None
 0.60A 6ebpC-1r2fA:
42.9		 6ebpC-1r2fA:
30.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r2f PROTEIN
(RIBONUCLEOTIDE
REDUCTASE R2)

(Salmonella
enterica) 		PF00268
(Ribonuc_red_sm) 		8 PHE A  60
LEU A  63
THR A  64
ASP A  67
ILE A 108
PHE A 109
PHE A 166
ILE A 188
 None
None
None
FE  A 400 (-3.0A)
None
None
None
None
 0.35A 6ebpC-1r2fA:
42.9		 6ebpC-1r2fA:
30.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rz9 REP PROTEIN

(Adeno-associated
dependoparvovirus
B) 		PF08724
(Rep_N) 		5 LEU A  53
THR A  54
ASP A  57
GLY A  32
ILE A  34
 None
 1.17A 6ebpC-1rz9A:
undetectable		 6ebpC-1rz9A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sma MALTOGENIC AMYLASE

(Thermus sp.
IM6501) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		5 LEU A 225
THR A 224
GLY A 177
ILE A 178
ILE A 198
 None
 1.12A 6ebpC-1smaA:
undetectable		 6ebpC-1smaA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Archaeoglobus
fulgidus) 		PF01513
(NAD_kinase) 		5 LEU A  76
THR A  77
SER A  45
GLY A  47
ILE A  65
 None
 1.10A 6ebpC-1suwA:
undetectable		 6ebpC-1suwA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uew MEMBRANE ASSOCIATED
GUANYLATE KINASE
INVERTED-2 (MAGI-2)

(Homo sapiens) 		PF00595
(PDZ) 		5 LEU A  97
THR A  96
GLY A  73
PHE A  26
ILE A  88
 None
 1.25A 6ebpC-1uewA:
undetectable		 6ebpC-1uewA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhm HISTONE H1

(Saccharomyces
cerevisiae) 		PF00538
(Linker_histone) 		5 PHE A  90
LEU A  50
GLY A  97
ILE A  94
PHE A  72
 None
 1.21A 6ebpC-1uhmA:
undetectable		 6ebpC-1uhmA:
24.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT

(Mycobacterium
tuberculosis) 		PF00268
(Ribonuc_red_sm) 		9 PHE A  65
LEU A  68
THR A  69
ASP A  72
SER A 109
ILE A 113
PHE A 114
PHE A 171
ILE A 193
 None
None
None
FE  A1292 (-2.5A)
None
None
None
None
None
 0.49A 6ebpC-1uzrA:
41.1		 6ebpC-1uzrA:
42.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkz PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermotoga
maritima) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 LEU A 278
GLY A  65
ILE A  63
PHE A 294
ILE A  18
 None
 1.26A 6ebpC-1vkzA:
undetectable		 6ebpC-1vkzA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlm SAM-DEPENDENT
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF08241
(Methyltransf_11) 		5 LEU A 162
GLY A 204
ILE A 202
PHE A 171
ILE A 100
 None
 0.90A 6ebpC-1vlmA:
undetectable		 6ebpC-1vlmA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT

(Methanocaldococcus
jannaschii) 		PF01420
(Methylase_S) 		5 LEU A 417
THR A 418
GLY A  14
ILE A  13
PHE A 129
 None
 1.04A 6ebpC-1yf2A:
undetectable		 6ebpC-1yf2A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a6o ISHP608 TRANSPOSASE

(Helicobacter
pylori) 		PF01797
(Y1_Tnp) 		5 PHE A  80
GLY A  76
ILE A  71
PHE A  75
ILE A 113
 None
 1.21A 6ebpC-2a6oA:
undetectable		 6ebpC-2a6oA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4m GLYCINE
BETAINE-BINDING
PROTEIN

(Bacillus
subtilis) 		PF04069
(OpuAC) 		5 THR A  31
ASP A  32
SER A  47
GLY A  20
ILE A  46
 None
 1.17A 6ebpC-2b4mA:
undetectable		 6ebpC-2b4mA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbz MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Homo sapiens) 		PF00005
(ABC_tran) 		5 PHE A 862
LEU A 856
SER A 851
GLY A 850
ILE A 838
 None
 1.12A 6ebpC-2cbzA:
undetectable		 6ebpC-2cbzA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwg PROTEIN RUFY3

(Mus musculus) 		PF02759
(RUN) 		5 PHE A 122
LEU A 119
GLY A 100
ILE A  98
ILE A 236
 None
 1.07A 6ebpC-2dwgA:
undetectable		 6ebpC-2dwgA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwm 65 KDA VIRULENCE
PROTEIN

(Salmonella
enterica) 		PF03496
(ADPrib_exo_Tox) 		5 LEU A 427
THR A 426
GLY A 405
ILE A 409
PHE A 443
 None
 1.02A 6ebpC-2gwmA:
undetectable		 6ebpC-2gwmA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk7 SHIKIMATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 PHE A  55
LEU A  58
GLY A  62
ILE A  63
PHE A  95
 None
 1.16A 6ebpC-2hk7A:
undetectable		 6ebpC-2hk7A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5g AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		5 PHE A 260
LEU A 263
THR A 264
GLY A 277
ILE A 279
 None
 1.01A 6ebpC-2i5gA:
undetectable		 6ebpC-2i5gA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id0 EXORIBONUCLEASE 2

(Escherichia
coli) 		PF00575
(S1)
PF00773
(RNB)
PF08206
(OB_RNB) 		5 PHE A 197
LEU A 212
THR A 199
ILE A 305
ILE A 228
 None
 1.13A 6ebpC-2id0A:
undetectable		 6ebpC-2id0A:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu4 DIHYDROXYACETONE
KINASE

(Lactococcus
lactis) 		PF02733
(Dak1) 		5 LEU A 185
THR A 184
ASP A 133
ILE A 303
ILE A 212
 None
 1.03A 6ebpC-2iu4A:
undetectable		 6ebpC-2iu4A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu4 DIHYDROXYACETONE
KINASE

(Lactococcus
lactis) 		PF02733
(Dak1) 		5 LEU A 305
GLY A 211
ILE A 212
PHE A 271
ILE A 231
 None
 1.12A 6ebpC-2iu4A:
undetectable		 6ebpC-2iu4A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l3f UNCHARACTERIZED
PROTEIN

(Methanosarcina
acetivorans) 		PF03167
(UDG) 		5 PHE A 112
LEU A  19
ASP A  74
GLY A 114
PHE A  97
 None
 1.05A 6ebpC-2l3fA:
undetectable		 6ebpC-2l3fA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oda HYPOTHETICAL PROTEIN
PSPTO_2114

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 SER A 171
GLY A 130
ILE A 173
PHE A   6
ILE A 186
 None
 1.20A 6ebpC-2odaA:
undetectable		 6ebpC-2odaA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00583
(Acetyltransf_1)
PF00696
(AA_kinase) 		5 LEU A 162
SER A  51
GLY A  54
ILE A  55
ILE A 167
 None
 1.13A 6ebpC-2r98A:
undetectable		 6ebpC-2r98A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmh FUCOLECTIN-RELATED
PROTEIN

(Streptococcus
pneumoniae) 		PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C) 		5 PHE A 360
LEU A 364
SER A 232
GLY A 229
ILE A 354
 None
 1.14A 6ebpC-2wmhA:
undetectable		 6ebpC-2wmhA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 LEU A   8
THR A   9
GLY A  29
ILE A  30
ILE A   2
 None
 1.22A 6ebpC-2xybA:
undetectable		 6ebpC-2xybA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypd PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C

(Homo sapiens) 		PF02373
(JmjC) 		5 PHE A2367
LEU A2380
GLY A2362
ILE A2363
PHE A2453
 None
 1.25A 6ebpC-2ypdA:
undetectable		 6ebpC-2ypdA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c75 METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN

(Paracoccus
versutus) 		PF06433
(Me-amine-dh_H) 		5 PHE H 102
THR H 115
ASP H 116
GLY H 113
ILE H 111
 None
 1.20A 6ebpC-3c75H:
undetectable		 6ebpC-3c75H:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cyg UNCHARACTERIZED
PROTEIN

(Fervidobacterium
nodosum) 		PF11738
(DUF3298)
PF13739
(DUF4163) 		5 PHE A 201
GLY A 207
ILE A 203
PHE A 197
ILE A 160
 None
 1.09A 6ebpC-3cygA:
undetectable		 6ebpC-3cygA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6j PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacteroides
fragilis) 		PF13419
(HAD_2) 		5 LEU A  14
THR A  13
SER A 109
ILE A 108
ILE A 116
 None
None
PO4  A 251 (-2.6A)
None
None
 1.17A 6ebpC-3d6jA:
undetectable		 6ebpC-3d6jA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb7 INSECTICIDAL
DELTA-ENDOTOXIN
CRY8EA1

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 PHE A 429
LEU A 479
GLY A 398
ILE A 397
ILE A 369
 None
 1.18A 6ebpC-3eb7A:
undetectable		 6ebpC-3eb7A:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgx RBSTP2171

(Geobacillus
stearothermophilus) 		no annotation 5 LEU A  91
THR A  92
ILE A  73
PHE A  70
ILE A  23
 None
 0.91A 6ebpC-3fgxA:
undetectable		 6ebpC-3fgxA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flo DNA POLYMERASE ALPHA
SUBUNIT B
DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N)
PF08996
(zf-DNA_Pol) 		5 LEU A 461
THR A 460
ASP A 462
GLY B1441
ILE B1330
 None
 1.16A 6ebpC-3floA:
undetectable		 6ebpC-3floA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcu OXYGEN-EVOLVING
ENHANCER PROTEIN 1,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF01716
(MSP) 		6 PHE O 301
LEU O 285
THR O 284
ILE O 321
PHE O 134
ILE O 213
 None
 1.40A 6ebpC-3jcuO:
undetectable		 6ebpC-3jcuO:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kre PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Ehrlichia
chaffeensis) 		PF01259
(SAICAR_synt) 		5 PHE A 166
LEU A 165
GLY A 170
ILE A 171
PHE A  56
 None
 1.08A 6ebpC-3kreA:
undetectable		 6ebpC-3kreA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Sulfolobus
solfataricus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 PHE A 223
THR A 195
ASP A 155
GLY A 233
ILE A 234
 None
 1.25A 6ebpC-3l7zA:
undetectable		 6ebpC-3l7zA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		5 PHE A 604
THR A 471
GLY A 599
ILE A 603
ILE A 457
 None
 0.86A 6ebpC-3lk6A:
undetectable		 6ebpC-3lk6A:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lx6 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		5 PHE A 103
SER A 105
GLY A 107
ILE A 106
PHE A  87
 None
 1.25A 6ebpC-3lx6A:
undetectable		 6ebpC-3lx6A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		5 PHE A 103
SER A 105
GLY A 107
ILE A 106
PHE A  87
 None
 1.12A 6ebpC-3me5A:
undetectable		 6ebpC-3me5A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjo RIBONUCLEOTIDE
REDUCTASE SUBUNIT
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		8 PHE A  70
LEU A  73
THR A  74
ASP A  77
ILE A 118
PHE A 119
PHE A 176
ILE A 198
 None
None
None
MN3  A1001 (-2.2A)
None
None
None
None
 0.69A 6ebpC-3mjoA:
41.0		 6ebpC-3mjoA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjo RIBONUCLEOTIDE
REDUCTASE SUBUNIT
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		6 PHE A  70
LEU A  73
THR A  74
SER A 114
ILE A 118
ILE A 198
 None
 0.62A 6ebpC-3mjoA:
41.0		 6ebpC-3mjoA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mp7 PREPROTEIN
TRANSLOCASE SUBUNIT
SECY

(Pyrococcus
furiosus) 		PF00344
(SecY)
PF10559
(Plug_translocon) 		5 LEU A 354
THR A 355
ILE A 333
PHE A 328
ILE A 299
 None
 1.15A 6ebpC-3mp7A:
undetectable		 6ebpC-3mp7A:
11.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n3b RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
SUBUNIT BETA

(Escherichia
coli) 		no annotation 8 PHE B  60
LEU B  63
THR B  64
ASP B  67
ILE B 108
PHE B 109
PHE B 166
ILE B 188
 None
None
None
MN  B 320 (-2.8A)
None
None
None
None
 0.42A 6ebpC-3n3bB:
42.2		 6ebpC-3n3bB:
30.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n3b RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
SUBUNIT BETA

(Escherichia
coli) 		no annotation 7 PHE B  60
LEU B  63
THR B  64
ASP B  67
SER B 104
ILE B 108
ILE B 188
 None
None
None
MN  B 320 (-2.8A)
None
None
None
 0.70A 6ebpC-3n3bB:
42.2		 6ebpC-3n3bB:
30.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nas BETA-PHOSPHOGLUCOMUT
ASE

(Bacillus
subtilis) 		PF13419
(HAD_2) 		5 LEU A   8
ASP A   7
GLY A 111
ILE A 135
PHE A 132
 None
 1.15A 6ebpC-3nasA:
undetectable		 6ebpC-3nasA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojl CAP5O

(Staphylococcus
aureus) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 LEU A 221
THR A 222
GLY A 251
ILE A 215
ILE A 236
 None
 1.10A 6ebpC-3ojlA:
undetectable		 6ebpC-3ojlA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd8 FUMARATE HYDRATASE
CLASS II

(Mycolicibacterium
smegmatis) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 LEU A 164
GLY A 208
ILE A 282
PHE A 381
ILE A 289
 None
 1.18A 6ebpC-3rd8A:
2.2		 6ebpC-3rd8A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrp PROBABLE FUMARATE
HYDRATASE FUM

(Mycobacteroides
abscessus) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 LEU A 165
GLY A 209
ILE A 283
PHE A 382
ILE A 290
 None
 1.17A 6ebpC-3rrpA:
2.2		 6ebpC-3rrpA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t33 G PROTEIN COUPLED
RECEPTOR

(Arabidopsis
thaliana) 		PF05147
(LANC_like) 		5 PHE A 384
LEU A  75
GLY A 389
ILE A 327
PHE A 121
 None
 1.19A 6ebpC-3t33A:
undetectable		 6ebpC-3t33A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkk PREDICTED
ACETAMIDASE/FORMAMID
ASE

(Caldanaerobacter
subterraneus) 		PF03069
(FmdA_AmdA) 		5 LEU A 160
THR A 159
GLY A 190
ILE A 273
ILE A 229
 None
 1.20A 6ebpC-3tkkA:
undetectable		 6ebpC-3tkkA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsw TIGHT JUNCTION
PROTEIN ZO-1

(Homo sapiens) 		PF00595
(PDZ)
PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		5 LEU A 549
THR A 548
ASP A 547
GLY A 440
ILE A 445
 None
 1.11A 6ebpC-3tswA:
undetectable		 6ebpC-3tswA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v1z ENDONUCLEASE
BSE634IR

(Geobacillus
stearothermophilus) 		PF07832
(Bse634I) 		5 LEU A  47
ASP A  48
SER A  42
GLY A  41
PHE A 280
 None
 1.23A 6ebpC-3v1zA:
undetectable		 6ebpC-3v1zA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apb FUMARATE HYDRATASE
CLASS II

(Mycobacterium
tuberculosis) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 LEU A 166
GLY A 210
ILE A 284
PHE A 383
ILE A 291
 None
 1.17A 6ebpC-4apbA:
undetectable		 6ebpC-4apbA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ar9 COLLAGENASE COLT

(Clostridium
tetani) 		PF01752
(Peptidase_M9) 		5 PHE A 554
LEU A 536
SER A 589
ILE A 594
ILE A 585
 None
 1.24A 6ebpC-4ar9A:
undetectable		 6ebpC-4ar9A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmr RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus cereus) 		PF00268
(Ribonuc_red_sm) 		7 LEU A  58
THR A  59
ASP A  62
ILE A 103
PHE A 104
PHE A 169
ILE A 191
 None
None
FE2  A1323 (-2.4A)
None
None
None
None
 0.41A 6ebpC-4bmrA:
38.6		 6ebpC-4bmrA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmr RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus cereus) 		PF00268
(Ribonuc_red_sm) 		6 LEU A  58
THR A  59
ASP A  62
SER A  99
ILE A 103
ILE A 191
 None
None
FE2  A1323 (-2.4A)
None
None
None
 0.66A 6ebpC-4bmrA:
38.6		 6ebpC-4bmrA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3z MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Homo sapiens) 		PF00005
(ABC_tran) 		5 PHE A 862
LEU A 856
SER A 851
GLY A 850
ILE A 838
 None
 1.15A 6ebpC-4c3zA:
undetectable		 6ebpC-4c3zA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT

(Vaccinia virus) 		PF03341
(Pox_mRNA-cap) 		5 LEU B 160
THR B 159
GLY B 164
ILE B 166
PHE B 248
 None
 1.13A 6ebpC-4ckeB:
undetectable		 6ebpC-4ckeB:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp6 CHOLINE BINDING
PROTEIN PCPA

(Streptococcus
pneumoniae) 		PF13306
(LRR_5) 		5 LEU A 345
GLY A 371
ILE A 370
PHE A 336
ILE A 331
 None
 1.15A 6ebpC-4cp6A:
undetectable		 6ebpC-4cp6A:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dr0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus
subtilis) 		PF00268
(Ribonuc_red_sm) 		8 LEU A  62
THR A  63
ASP A  66
SER A 104
ILE A 108
PHE A 109
PHE A 172
ILE A 194
 None
None
MN  A 402 (-2.3A)
None
None
None
None
None
 0.48A 6ebpC-4dr0A:
38.7		 6ebpC-4dr0A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efh ACTIN-1

(Acanthamoeba
castellanii) 		PF00022
(Actin) 		5 PHE A 306
SER A 155
GLY A 302
PHE A 262
ILE A 274
 ADP  A 403 (-3.7A)
None
ADP  A 403 (-3.3A)
None
None
 1.19A 6ebpC-4efhA:
undetectable		 6ebpC-4efhA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN

(Bacteroides
caccae) 		PF07523
(Big_3)
PF13306
(LRR_5) 		5 PHE A 294
GLY A 268
ILE A 267
PHE A 332
ILE A 318
 None
SO4  A 512 ( 4.3A)
None
None
None
 1.22A 6ebpC-4fd0A:
undetectable		 6ebpC-4fd0A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN

(Bacteroides
caccae) 		PF07523
(Big_3)
PF13306
(LRR_5) 		5 PHE A 294
LEU A 323
ILE A 267
PHE A 332
ILE A 318
 None
 1.11A 6ebpC-4fd0A:
undetectable		 6ebpC-4fd0A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdw LEUCINE RICH
HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF07523
(Big_3)
PF13306
(LRR_5) 		5 PHE A 294
LEU A 323
ILE A 267
PHE A 332
ILE A 318
 None
 1.18A 6ebpC-4fdwA:
undetectable		 6ebpC-4fdwA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hmw PYRIDOXAMINE
5'-PHOSPHATE OXIDASE

(Burkholderia
lata) 		PF01243
(Putative_PNPOx)
PF10590
(PNP_phzG_C) 		5 PHE A  67
LEU A  49
GLY A  74
ILE A  70
ILE A 108
 None
 1.20A 6ebpC-4hmwA:
undetectable		 6ebpC-4hmwA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3y NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 PHE A 374
LEU A 397
ILE A 404
PHE A 446
ILE A 444
 None
 1.09A 6ebpC-4k3yA:
undetectable		 6ebpC-4k3yA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lza ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermoanaerobacter
pseudethanolicus) 		PF00156
(Pribosyltran) 		5 PHE A 171
LEU A 151
THR A 152
SER A 167
ILE A 169
 None
None
None
CL  A 201 (-4.7A)
None
 1.22A 6ebpC-4lzaA:
undetectable		 6ebpC-4lzaA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n83 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Streptococcus
sanguinis) 		PF00268
(Ribonuc_red_sm) 		9 PHE A  59
LEU A  62
THR A  63
ASP A  66
SER A 103
ILE A 107
PHE A 108
PHE A 165
ILE A 187
 None
None
None
MN  A 402 (-2.8A)
None
None
None
None
None
 0.46A 6ebpC-4n83A:
38.8		 6ebpC-4n83A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5w CALCIUM-BINDING
MITOCHONDRIAL
CARRIER PROTEIN
ARALAR2,CALCIUM-BIND
ING MITOCHONDRIAL
CARRIER PROTEIN
ARALAR2

(Homo sapiens) 		no annotation 5 THR A 265
GLY A 222
ILE A 271
PHE A 254
ILE A 233
 None
 0.95A 6ebpC-4p5wA:
undetectable		 6ebpC-4p5wA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl7 ACTIN,THYMOSIN
BETA-4

(Homo sapiens;
Komagataella
phaffii) 		PF00022
(Actin)
PF01290
(Thymosin) 		5 PHE A 306
SER A 155
GLY A 302
PHE A 262
ILE A 274
 ATP  A 501 (-3.6A)
None
ATP  A 501 (-3.4A)
None
None
 1.17A 6ebpC-4pl7A:
undetectable		 6ebpC-4pl7A:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288

(Thermotoga
maritima) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 LEU B  93
THR B  90
SER B  50
GLY B  53
ILE B  51
 None
 1.18A 6ebpC-4q4aB:
2.4		 6ebpC-4q4aB:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvj COHESIN SUBUNIT SCC3

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 860
GLY A 817
ILE A 822
PHE A 832
ILE A 810
 None
 1.15A 6ebpC-4uvjA:
undetectable		 6ebpC-4uvjA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yis MEGANUCLEASE I-CPAMI

(Cryphonectria
parasitica) 		PF00961
(LAGLIDADG_1) 		5 SER A 178
GLY A 201
ILE A 202
PHE A 237
ILE A 258
 None
 1.23A 6ebpC-4yisA:
undetectable		 6ebpC-4yisA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bym SUPPRESSOR PROTEIN
MPT5

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		5 LEU A 387
SER A 374
GLY A 379
ILE A 373
ILE A 402
 None
 1.20A 6ebpC-5bymA:
undetectable		 6ebpC-5bymA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epf PEROXIREDOXIN

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		5 PHE A  43
THR A 126
GLY A  75
ILE A  76
ILE A 129
 None
 1.24A 6ebpC-5epfA:
undetectable		 6ebpC-5epfA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 PHE A 168
LEU A 173
SER A 218
GLY A 192
ILE A 191
 None
 0.96A 6ebpC-5gr8A:
undetectable		 6ebpC-5gr8A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcf CALRETICULIN,
PUTATIVE,CALRETICULI
N, PUTATIVE

(Trypanosoma
cruzi) 		PF00262
(Calreticulin) 		5 LEU A  67
THR A  68
SER A  51
ILE A  50
ILE A 327
 None
 1.20A 6ebpC-5hcfA:
undetectable		 6ebpC-5hcfA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF11864
(DUF3384) 		5 PHE A 207
LEU A 210
THR A 211
GLY A 276
ILE A 274
 PHE  A 207 ( 1.3A)
LEU  A 210 ( 0.5A)
THR  A 211 ( 0.8A)
GLY  A 276 ( 0.0A)
ILE  A 274 ( 0.7A)
 0.89A 6ebpC-5hiuA:
undetectable		 6ebpC-5hiuA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvn 3-DEHYDROQUINATE
SYNTHASE

(Francisella
tularensis) 		PF01761
(DHQ_synthase) 		5 PHE A 190
ASP A 277
GLY A 246
PHE A 245
ILE A 304
 None
None
CL  A 402 (-3.7A)
None
None
 1.22A 6ebpC-5hvnA:
undetectable		 6ebpC-5hvnA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA

(Geobacillus
stearothermophilus) 		no annotation 5 LEU B 242
THR B 310
GLY B 332
PHE B 286
ILE B 244
 None
 1.17A 6ebpC-5ivlB:
undetectable		 6ebpC-5ivlB:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy7 TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT BETA

(Homo sapiens) 		PF02186
(TFIIE_beta) 		5 LEU R  97
THR R  98
GLY R 135
ILE R 133
ILE R 130
 None
 1.07A 6ebpC-5iy7R:
undetectable		 6ebpC-5iy7R:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j4r WELO5

(Hapalosiphon
welwitschii) 		no annotation 5 PHE A 120
ILE A 192
PHE A  47
PHE A 106
ILE A 152
 None
 1.11A 6ebpC-5j4rA:
undetectable		 6ebpC-5j4rA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8j DIVALENT METAL
CATION TRANSPORTER
MNTH

(Eremococcus
coleocola) 		PF01566
(Nramp) 		5 PHE A 114
LEU A 117
THR A 118
SER A 417
ILE A 102
 None
 1.17A 6ebpC-5m8jA:
3.0		 6ebpC-5m8jA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr3 DIHYDROLIPOYL
DEHYDROGENASE

(Pseudomonas
putida) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 PHE A 437
THR A 439
ASP A 443
GLY A 431
ILE A 433
 TRS  A 502 ( 4.2A)
None
None
None
None
 1.14A 6ebpC-5tr3A:
undetectable		 6ebpC-5tr3A:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucd NAD(P)-DEPENDENT
BENZALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 LEU A 127
THR A 128
GLY A 132
ILE A 134
ILE A 142
 None
 0.99A 6ebpC-5ucdA:
undetectable		 6ebpC-5ucdA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA

(Clostridium
pasteurianum;
Homo sapiens) 		PF00001
(7tm_1)
PF00301
(Rubredoxin) 		5 PHE A  78
LEU A  81
THR A  82
GLY A 106
ILE A 110
 None
OLC  A1103 ( 4.6A)
None
None
None
 1.11A 6ebpC-5uiwA:
undetectable		 6ebpC-5uiwA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT

(Saccharomyces
cerevisiae) 		no annotation 5 LEU G 117
GLY G  67
ILE G  65
PHE G 224
ILE G  97
 None
 1.08A 6ebpC-5uz5G:
undetectable		 6ebpC-5uz5G:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v3s TWO-COMPONENT
INSECTICIDAL PROTEIN
16 KDA UNIT

(Alcaligenes
faecalis) 		PF06355
(Aegerolysin) 		5 PHE A  97
LEU A 113
ASP A 111
GLY A  86
ILE A 138
 None
 1.02A 6ebpC-5v3sA:
undetectable		 6ebpC-5v3sA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wln TYPE II SECRETION
SYSTEM PROTEIN D

(Pseudomonas
aeruginosa) 		no annotation 5 THR G 309
SER G 268
GLY G 270
ILE G 267
ILE G 292
 None
 1.16A 6ebpC-5wlnG:
undetectable		 6ebpC-5wlnG:
7.82