SIMILAR PATTERNS OF AMINO ACIDS FOR 6EBP_A_DAHA123

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		5 LEU A 298
ASP A 302
SER A 193
GLY A 191
PHE A 190
 None
 1.15A 6ebpA-1biyA:
0.0		 6ebpA-1biyA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1z TNSA ENDONUCLEASE

(Escherichia
coli) 		PF08721
(Tn7_Tnp_TnsA_C)
PF08722
(Tn7_Tnp_TnsA_N) 		5 LEU A 235
THR A 236
ILE A 210
PHE A 249
ILE A 259
 None
 1.24A 6ebpA-1f1zA:
undetectable		 6ebpA-1f1zA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jnf SEROTRANSFERRIN

(Oryctolagus
cuniculus) 		PF00405
(Transferrin) 		5 LEU A 293
ASP A 297
SER A 189
GLY A 187
PHE A 186
 None
None
None
CL  A 800 (-3.5A)
None
 1.16A 6ebpA-1jnfA:
undetectable		 6ebpA-1jnfA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 LEU A 540
ASP A 541
GLY A 530
ILE A 528
PHE A 477
 None
 1.13A 6ebpA-1jx2A:
0.0		 6ebpA-1jx2A:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgp RIBONUCLEOTIDE
REDUCTASE PROTEIN
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		7 LEU A  73
THR A  74
ASP A  77
ILE A 118
PHE A 119
PHE A 176
ILE A 198
 None
None
MN  A1001 (-2.7A)
None
None
None
None
 0.52A 6ebpA-1kgpA:
42.4		 6ebpA-1kgpA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgp RIBONUCLEOTIDE
REDUCTASE PROTEIN
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		6 LEU A  73
THR A  74
ASP A  77
SER A 114
ILE A 118
ILE A 198
 None
None
MN  A1001 (-2.7A)
None
None
None
 0.69A 6ebpA-1kgpA:
42.4		 6ebpA-1kgpA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lc0 BILIVERDIN REDUCTASE
A

(Rattus
norvegicus) 		PF01408
(GFO_IDH_MocA)
PF09166
(Biliv-reduc_cat) 		5 LEU A 189
THR A 188
ILE A 215
PHE A 163
ILE A 287
 None
 1.17A 6ebpA-1lc0A:
0.0		 6ebpA-1lc0A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxy ARGININE DEIMINASE

(Mycoplasma
arginini) 		PF02274
(Amidinotransf) 		5 LEU A 274
THR A 275
GLY A 350
ILE A 332
PHE A 292
 None
 1.32A 6ebpA-1lxyA:
0.0		 6ebpA-1lxyA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mwo ALPHA AMYLASE

(Pyrococcus
woesei) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 SER A 189
GLY A 191
ILE A 190
PHE A 192
PHE A  68
 None
 1.34A 6ebpA-1mwoA:
0.0		 6ebpA-1mwoA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nlu SEDOLISIN

(Pseudomonas sp.) 		no annotation 5 LEU A 206
THR A 204
GLY A 354
PHE A  13
ILE A 292
 None
 1.25A 6ebpA-1nluA:
0.0		 6ebpA-1nluA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pv5 HYPOTHETICAL PROTEIN
YWQG

(Bacillus
subtilis) 		PF09234
(DUF1963) 		5 THR A 156
ASP A 157
GLY A 190
PHE A 191
PHE A 240
 None
 1.15A 6ebpA-1pv5A:
undetectable		 6ebpA-1pv5A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhl PROTEIN (CELL
DIVISION PROTEIN
MUKB)

(Escherichia
coli) 		PF04310
(MukB) 		5 LEU A  90
THR A  92
GLY A 182
ILE A 184
PHE A  47
 None
 1.21A 6ebpA-1qhlA:
undetectable		 6ebpA-1qhlA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjm LACTOFERRIN

(Equus caballus) 		PF00405
(Transferrin) 		5 LEU A 298
ASP A 302
SER A 193
GLY A 191
PHE A 190
 None
 1.11A 6ebpA-1qjmA:
undetectable		 6ebpA-1qjmA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1

(Pinus taeda) 		PF05368
(NmrA) 		5 THR A  84
GLY A  86
ILE A  90
PHE A 109
ILE A  96
 None
 1.23A 6ebpA-1qycA:
undetectable		 6ebpA-1qycA:
14.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r2f PROTEIN
(RIBONUCLEOTIDE
REDUCTASE R2)

(Salmonella
enterica) 		PF00268
(Ribonuc_red_sm) 		7 LEU A  63
THR A  64
ASP A  67
ILE A 108
PHE A 109
PHE A 166
ILE A 188
 None
None
FE  A 400 (-3.0A)
None
None
None
None
 0.44A 6ebpA-1r2fA:
43.0		 6ebpA-1r2fA:
30.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r2f PROTEIN
(RIBONUCLEOTIDE
REDUCTASE R2)

(Salmonella
enterica) 		PF00268
(Ribonuc_red_sm) 		7 LEU A  63
THR A  64
ASP A  67
SER A 104
ILE A 108
PHE A 109
ILE A 188
 None
None
FE  A 400 (-3.0A)
None
None
None
None
 0.64A 6ebpA-1r2fA:
43.0		 6ebpA-1r2fA:
30.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rz9 REP PROTEIN

(Adeno-associated
dependoparvovirus
B) 		PF08724
(Rep_N) 		5 LEU A  53
THR A  54
ASP A  57
GLY A  32
ILE A  34
 None
 1.14A 6ebpA-1rz9A:
undetectable		 6ebpA-1rz9A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suu DNA GYRASE SUBUNIT A

(Borreliella
burgdorferi) 		PF03989
(DNA_gyraseA_C) 		5 THR A 652
GLY A 622
ILE A 624
PHE A 701
ILE A 643
 None
 1.33A 6ebpA-1suuA:
undetectable		 6ebpA-1suuA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Archaeoglobus
fulgidus) 		PF01513
(NAD_kinase) 		5 LEU A  76
THR A  77
SER A  45
GLY A  47
ILE A  65
 None
 1.13A 6ebpA-1suwA:
undetectable		 6ebpA-1suwA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0u DIHYDROPINOSYLVIN
SYNTHASE

(Pinus
sylvestris) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A 266
THR A 200
SER A 211
GLY A 214
PHE A 218
 None
 1.32A 6ebpA-1u0uA:
undetectable		 6ebpA-1u0uA:
12.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT

(Mycobacterium
tuberculosis) 		PF00268
(Ribonuc_red_sm) 		8 LEU A  68
THR A  69
ASP A  72
SER A 109
ILE A 113
PHE A 114
PHE A 171
ILE A 193
 None
None
FE  A1292 (-2.5A)
None
None
None
None
None
 0.51A 6ebpA-1uzrA:
41.3		 6ebpA-1uzrA:
42.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vka MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 1

(Homo sapiens) 		PF00307
(CH) 		5 LEU A  51
SER A  55
GLY A  54
ILE A  56
PHE A 114
 None
 1.35A 6ebpA-1vkaA:
undetectable		 6ebpA-1vkaA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkz PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermotoga
maritima) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 LEU A 278
GLY A  65
ILE A  63
PHE A 294
ILE A  18
 None
 1.28A 6ebpA-1vkzA:
undetectable		 6ebpA-1vkzA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlm SAM-DEPENDENT
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF08241
(Methyltransf_11) 		5 LEU A 162
GLY A 204
ILE A 202
PHE A 171
ILE A 100
 None
 0.87A 6ebpA-1vlmA:
undetectable		 6ebpA-1vlmA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT

(Methanocaldococcus
jannaschii) 		PF01420
(Methylase_S) 		5 LEU A 417
THR A 418
GLY A  14
ILE A  13
PHE A 129
 None
 1.00A 6ebpA-1yf2A:
undetectable		 6ebpA-1yf2A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4m GLYCINE
BETAINE-BINDING
PROTEIN

(Bacillus
subtilis) 		PF04069
(OpuAC) 		5 THR A  31
ASP A  32
SER A  47
GLY A  20
ILE A  46
 None
 1.13A 6ebpA-2b4mA:
undetectable		 6ebpA-2b4mA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dmw SYNAPTOBREVIN-LIKE 1
VARIANT

(Homo sapiens) 		PF13774
(Longin) 		5 LEU A  50
THR A  51
ILE A  62
PHE A  83
ILE A  43
 None
 1.31A 6ebpA-2dmwA:
undetectable		 6ebpA-2dmwA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7z ACETYLENE HYDRATASE
AHY

(Pelobacter
acetylenicus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 LEU A 599
THR A 671
GLY A 721
ILE A 723
ILE A 674
 None
 1.17A 6ebpA-2e7zA:
undetectable		 6ebpA-2e7zA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjn HYPOTHETICAL PROTEIN
PA1024

(Pseudomonas
aeruginosa) 		PF03060
(NMO) 		5 LEU A  41
GLY A 201
PHE A 204
PHE A   8
ILE A 176
 None
FMN  A1904 (-3.3A)
None
None
None
 1.35A 6ebpA-2gjnA:
undetectable		 6ebpA-2gjnA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwm 65 KDA VIRULENCE
PROTEIN

(Salmonella
enterica) 		PF03496
(ADPrib_exo_Tox) 		5 LEU A 427
THR A 426
GLY A 405
ILE A 409
PHE A 443
 None
 1.06A 6ebpA-2gwmA:
undetectable		 6ebpA-2gwmA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf0 BILE SALT HYDROLASE

(Bifidobacterium
longum) 		PF02275
(CBAH) 		5 LEU A 170
SER A 150
GLY A 145
PHE A  15
PHE A 226
 None
 1.35A 6ebpA-2hf0A:
undetectable		 6ebpA-2hf0A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxs RAS-RELATED PROTEIN
RAB-28

(Homo sapiens) 		PF00071
(Ras) 		5 LEU A  28
THR A  26
GLY A  70
ILE A  69
PHE A 170
 None
MG  A 402 ( 3.0A)
MG  A 402 ( 4.5A)
None
None
 1.34A 6ebpA-2hxsA:
undetectable		 6ebpA-2hxsA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxs RAS-RELATED PROTEIN
RAB-28

(Homo sapiens) 		PF00071
(Ras) 		5 LEU A  28
THR A  26
GLY A  70
PHE A 170
ILE A  66
 None
MG  A 402 ( 3.0A)
MG  A 402 ( 4.5A)
None
None
 1.26A 6ebpA-2hxsA:
undetectable		 6ebpA-2hxsA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu4 DIHYDROXYACETONE
KINASE

(Lactococcus
lactis) 		PF02733
(Dak1) 		5 LEU A 185
THR A 184
ASP A 133
ILE A 303
ILE A 212
 None
 1.02A 6ebpA-2iu4A:
undetectable		 6ebpA-2iu4A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu4 DIHYDROXYACETONE
KINASE

(Lactococcus
lactis) 		PF02733
(Dak1) 		5 LEU A 305
GLY A 211
ILE A 212
PHE A 271
ILE A 231
 None
 1.09A 6ebpA-2iu4A:
undetectable		 6ebpA-2iu4A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kkn UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF12850
(Metallophos_2) 		5 LEU A 112
SER A   8
GLY A  37
ILE A   7
PHE A 152
 None
 1.31A 6ebpA-2kknA:
undetectable		 6ebpA-2kknA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oda HYPOTHETICAL PROTEIN
PSPTO_2114

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 SER A 171
GLY A 130
ILE A 173
PHE A   6
ILE A 186
 None
 1.20A 6ebpA-2odaA:
undetectable		 6ebpA-2odaA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjz MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 1

(Homo sapiens) 		PF00307
(CH) 		5 LEU A  51
SER A  55
GLY A  54
ILE A  56
PHE A 114
 None
 1.29A 6ebpA-2qjzA:
undetectable		 6ebpA-2qjzA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8u MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 1

(Homo sapiens) 		PF00307
(CH) 		5 LEU A  51
SER A  55
GLY A  54
ILE A  56
PHE A 114
 None
 1.30A 6ebpA-2r8uA:
undetectable		 6ebpA-2r8uA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00583
(Acetyltransf_1)
PF00696
(AA_kinase) 		5 LEU A 162
SER A  51
GLY A  54
ILE A  55
ILE A 167
 None
 1.17A 6ebpA-2r98A:
undetectable		 6ebpA-2r98A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
PROTEIN TRANSPORT
PROTEIN SEB2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00344
(SecY)
PF10559
(Plug_translocon)
PF03911
(Sec61_beta) 		5 SER C  68
GLY C  70
ILE C  72
PHE C  73
PHE A  38
 None
 1.33A 6ebpA-2ww9C:
undetectable		 6ebpA-2ww9C:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 LEU A   8
THR A   9
GLY A  29
ILE A  30
ILE A   2
 None
 1.25A 6ebpA-2xybA:
undetectable		 6ebpA-2xybA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn9 POTASSIUM-TRANSPORTI
NG ATPASE ALPHA
CHAIN 1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF09040
(H-K_ATPase_N)
PF13246
(Cation_ATPase) 		5 LEU A 796
THR A 797
GLY A 874
ILE A 935
PHE A 931
 None
 1.33A 6ebpA-2yn9A:
3.2		 6ebpA-2yn9A:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0g HEMOGLOBIN SUBUNIT
ALPHA

(Cavia porcellus) 		PF00042
(Globin) 		5 LEU A  66
THR A  67
GLY A  18
ILE A  17
PHE A 128
 HEM  A 201 ( 4.4A)
None
None
None
None
 1.29A 6ebpA-3a0gA:
undetectable		 6ebpA-3a0gA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a18 ALDOXIME DEHYDRATASE

(Rhodococcus
erythropolis) 		PF13816
(Dehydratase_hem) 		5 LEU A 145
THR A 144
SER A 163
ILE A 162
ILE A 166
 BXO  A 355 ( 4.7A)
None
None
None
None
 1.28A 6ebpA-3a18A:
undetectable		 6ebpA-3a18A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 296
THR A 297
SER A 302
ILE A 303
PHE A 306
PHE A 226
 None
 1.42A 6ebpA-3d5fA:
3.4		 6ebpA-3d5fA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 LEU A1195
THR A1194
ILE A1074
PHE A1206
ILE A1095
 None
 1.31A 6ebpA-3ecqA:
undetectable		 6ebpA-3ecqA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		5 LEU A 208
GLY A 219
ILE A 241
PHE A 234
PHE A 227
 None
 1.20A 6ebpA-3eqnA:
undetectable		 6ebpA-3eqnA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewn THIJ/PFPI FAMILY
PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF01965
(DJ-1_PfpI) 		5 LEU A 128
SER A 157
GLY A 161
PHE A 184
PHE A 263
 None
None
None
None
GOL  A3968 (-3.9A)
 1.23A 6ebpA-3ewnA:
undetectable		 6ebpA-3ewnA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgx RBSTP2171

(Geobacillus
stearothermophilus) 		no annotation 5 LEU A  91
THR A  92
ILE A  73
PHE A  70
ILE A  23
 None
 0.89A 6ebpA-3fgxA:
undetectable		 6ebpA-3fgxA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flo DNA POLYMERASE ALPHA
SUBUNIT B
DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N)
PF08996
(zf-DNA_Pol) 		5 LEU A 461
THR A 460
ASP A 462
GLY B1441
ILE B1330
 None
 1.19A 6ebpA-3floA:
undetectable		 6ebpA-3floA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg0 KLEBSIELLA
PNEUMONIAE BLRP1

(Klebsiella
pneumoniae) 		PF00563
(EAL)
PF04940
(BLUF) 		5 LEU A   5
GLY A  38
ILE A  36
PHE A  62
ILE A  65
 None
None
None
None
FMN  A 504 (-4.5A)
 1.30A 6ebpA-3gg0A:
undetectable		 6ebpA-3gg0A:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG

(Clostridium
acetobutylicum) 		PF06838
(Met_gamma_lyase) 		5 LEU A 424
GLY A 416
ILE A 351
PHE A 338
ILE A 336
 None
 1.27A 6ebpA-3hvyA:
undetectable		 6ebpA-3hvyA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwc CHLOROPHENOL-4-MONOO
XYGENASE COMPONENT 2

(Burkholderia
cepacia) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		5 LEU A3383
SER A3387
GLY A3424
ILE A3423
ILE A3314
 None
 1.31A 6ebpA-3hwcA:
undetectable		 6ebpA-3hwcA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjo RIBONUCLEOTIDE
REDUCTASE SUBUNIT
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		7 LEU A  73
THR A  74
ASP A  77
ILE A 118
PHE A 119
PHE A 176
ILE A 198
 None
None
MN3  A1001 (-2.2A)
None
None
None
None
 0.71A 6ebpA-3mjoA:
41.1		 6ebpA-3mjoA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjo RIBONUCLEOTIDE
REDUCTASE SUBUNIT
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		6 LEU A  73
THR A  74
ASP A  77
SER A 114
ILE A 118
ILE A 198
 None
None
MN3  A1001 (-2.2A)
None
None
None
 0.71A 6ebpA-3mjoA:
41.1		 6ebpA-3mjoA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n00 REV-ERBA-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 545
THR A 541
ILE A 299
PHE A 300
ILE A 457
 None
 1.08A 6ebpA-3n00A:
undetectable		 6ebpA-3n00A:
15.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n3b RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
SUBUNIT BETA

(Escherichia
coli) 		no annotation 7 LEU B  63
THR B  64
ASP B  67
ILE B 108
PHE B 109
PHE B 166
ILE B 188
 None
None
MN  B 320 (-2.8A)
None
None
None
None
 0.46A 6ebpA-3n3bB:
42.2		 6ebpA-3n3bB:
30.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n3b RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
SUBUNIT BETA

(Escherichia
coli) 		no annotation 6 LEU B  63
THR B  64
ASP B  67
SER B 104
ILE B 108
ILE B 188
 None
None
MN  B 320 (-2.8A)
None
None
None
 0.76A 6ebpA-3n3bB:
42.2		 6ebpA-3n3bB:
30.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oee ATP SYNTHASE SUBUNIT
ALPHA

(Saccharomyces
cerevisiae) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 LEU A 218
SER A 231
GLY A 107
ILE A 232
ILE A 185
 None
 1.21A 6ebpA-3oeeA:
undetectable		 6ebpA-3oeeA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojl CAP5O

(Staphylococcus
aureus) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 LEU A 221
THR A 222
GLY A 251
ILE A 215
ILE A 236
 None
 1.11A 6ebpA-3ojlA:
undetectable		 6ebpA-3ojlA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouu BIOTIN CARBOXYLASE

(Campylobacter
jejuni) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LEU A  62
SER A  34
GLY A  53
ILE A  52
PHE A  85
 None
 1.09A 6ebpA-3ouuA:
undetectable		 6ebpA-3ouuA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkk PREDICTED
ACETAMIDASE/FORMAMID
ASE

(Caldanaerobacter
subterraneus) 		PF03069
(FmdA_AmdA) 		5 LEU A 160
THR A 159
GLY A 190
ILE A 273
ILE A 229
 None
 1.18A 6ebpA-3tkkA:
undetectable		 6ebpA-3tkkA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsw TIGHT JUNCTION
PROTEIN ZO-1

(Homo sapiens) 		PF00595
(PDZ)
PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		5 LEU A 549
THR A 548
ASP A 547
GLY A 440
ILE A 445
 None
 1.19A 6ebpA-3tswA:
undetectable		 6ebpA-3tswA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v1z ENDONUCLEASE
BSE634IR

(Geobacillus
stearothermophilus) 		PF07832
(Bse634I) 		5 LEU A  47
ASP A  48
SER A  42
GLY A  41
PHE A 280
 None
 1.20A 6ebpA-3v1zA:
undetectable		 6ebpA-3v1zA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF01554
(MatE) 		5 LEU A 143
GLY A 108
ILE A 111
PHE A  63
ILE A  67
 None
 1.28A 6ebpA-3wbnA:
undetectable		 6ebpA-3wbnA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmr RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus cereus) 		PF00268
(Ribonuc_red_sm) 		7 LEU A  58
THR A  59
ASP A  62
ILE A 103
PHE A 104
PHE A 169
ILE A 191
 None
None
FE2  A1323 (-2.4A)
None
None
None
None
 0.49A 6ebpA-4bmrA:
38.7		 6ebpA-4bmrA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmr RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus cereus) 		PF00268
(Ribonuc_red_sm) 		7 LEU A  58
THR A  59
ASP A  62
SER A  99
ILE A 103
PHE A 169
ILE A 191
 None
None
FE2  A1323 (-2.4A)
None
None
None
None
 0.68A 6ebpA-4bmrA:
38.7		 6ebpA-4bmrA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckb MRNA-CAPPING ENZYME
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03291
(Pox_MCEL)
PF10640
(Pox_ATPase-GT) 		5 LEU A 700
THR A 701
PHE A 780
PHE A 659
ILE A 597
 None
 1.17A 6ebpA-4ckbA:
undetectable		 6ebpA-4ckbA:
6.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT

(Vaccinia virus) 		PF03341
(Pox_mRNA-cap) 		5 LEU B 160
THR B 159
GLY B 164
ILE B 166
PHE B 248
 None
 1.19A 6ebpA-4ckeB:
undetectable		 6ebpA-4ckeB:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp6 CHOLINE BINDING
PROTEIN PCPA

(Streptococcus
pneumoniae) 		PF13306
(LRR_5) 		5 LEU A 345
GLY A 371
ILE A 370
PHE A 336
ILE A 331
 None
 1.18A 6ebpA-4cp6A:
undetectable		 6ebpA-4cp6A:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ct3 ORF30/ORF32

(Staphylococcus
virus K) 		PF05257
(CHAP) 		5 LEU A 155
GLY A 116
ILE A 118
PHE A 130
ILE A 132
 None
None
CMH  A1166 (-4.7A)
None
None
 1.34A 6ebpA-4ct3A:
undetectable		 6ebpA-4ct3A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dr0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus
subtilis) 		PF00268
(Ribonuc_red_sm) 		8 LEU A  62
THR A  63
ASP A  66
SER A 104
ILE A 108
PHE A 109
PHE A 172
ILE A 194
 None
None
MN  A 402 (-2.3A)
None
None
None
None
None
 0.54A 6ebpA-4dr0A:
38.8		 6ebpA-4dr0A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3y NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 LEU A 397
SER A 402
ILE A 404
PHE A 446
ILE A 444
 None
 1.27A 6ebpA-4k3yA:
undetectable		 6ebpA-4k3yA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqn D-HYDANTOINASE

(Bacillus sp.
AR9) 		PF01979
(Amidohydro_1) 		5 ASP A 390
SER A  88
GLY A  54
ILE A  55
ILE A 453
 ASP  A 390 ( 0.6A)
SER  A  88 ( 0.0A)
GLY  A  54 ( 0.0A)
ILE  A  55 ( 0.6A)
ILE  A 453 ( 0.8A)
 1.25A 6ebpA-4kqnA:
undetectable		 6ebpA-4kqnA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1n CONSERVED
LIPOPROTEIN,
PUTATIVE

(Clostridium
novyi) 		PF15525
(DUF4652) 		5 LEU A 145
THR A 153
GLY A 117
PHE A  86
ILE A 130
 None
 1.35A 6ebpA-4l1nA:
undetectable		 6ebpA-4l1nA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lm8 EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT MTRC

(Shewanella
oneidensis) 		PF14522
(Cytochrome_C7) 		5 LEU A 521
THR A 518
GLY A 334
ILE A 335
PHE A 438
 None
EDO  A 823 ( 4.7A)
None
None
HEC  A 807 (-4.6A)
 1.33A 6ebpA-4lm8A:
undetectable		 6ebpA-4lm8A:
6.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 680
SER A 584
GLY A 654
ILE A 587
PHE A 650
 None
 1.33A 6ebpA-4m7eA:
undetectable		 6ebpA-4m7eA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n83 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Streptococcus
sanguinis) 		PF00268
(Ribonuc_red_sm) 		8 LEU A  62
THR A  63
ASP A  66
SER A 103
ILE A 107
PHE A 108
PHE A 165
ILE A 187
 None
None
MN  A 402 (-2.8A)
None
None
None
None
None
 0.47A 6ebpA-4n83A:
38.9		 6ebpA-4n83A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5w CALCIUM-BINDING
MITOCHONDRIAL
CARRIER PROTEIN
ARALAR2,CALCIUM-BIND
ING MITOCHONDRIAL
CARRIER PROTEIN
ARALAR2

(Homo sapiens) 		no annotation 5 THR A 265
GLY A 222
ILE A 271
PHE A 254
ILE A 233
 None
 0.95A 6ebpA-4p5wA:
undetectable		 6ebpA-4p5wA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvj COHESIN SUBUNIT SCC3

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 860
GLY A 817
ILE A 822
PHE A 832
ILE A 810
 None
 1.14A 6ebpA-4uvjA:
undetectable		 6ebpA-4uvjA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6v DI-/TRIPEPTIDE
TRANSPORTER

(Yersinia
enterocolitica) 		PF00854
(PTR2) 		5 LEU A  43
SER A 173
GLY A 185
ILE A  37
PHE A 186
 None
 1.32A 6ebpA-4w6vA:
undetectable		 6ebpA-4w6vA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wed ABC TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Sinorhizobium
meliloti) 		PF00496
(SBP_bac_5) 		5 LEU A 157
GLY A  90
ILE A  87
PHE A 430
ILE A 471
 None
 1.33A 6ebpA-4wedA:
undetectable		 6ebpA-4wedA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yis MEGANUCLEASE I-CPAMI

(Cryphonectria
parasitica) 		PF00961
(LAGLIDADG_1) 		5 SER A 178
GLY A 201
ILE A 202
PHE A 237
ILE A 258
 None
 1.24A 6ebpA-4yisA:
undetectable		 6ebpA-4yisA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 LEU A1195
THR A1194
ILE A1074
PHE A1206
ILE A1095
 None
 1.32A 6ebpA-5a55A:
undetectable		 6ebpA-5a55A:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bym SUPPRESSOR PROTEIN
MPT5

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		5 LEU A 387
SER A 374
GLY A 379
ILE A 373
ILE A 402
 None
 1.21A 6ebpA-5bymA:
undetectable		 6ebpA-5bymA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csa ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00364
(Biotin_lipoyl)
PF08326
(ACC_central) 		5 LEU A1357
THR A1358
GLY A1405
PHE A1389
ILE A1425
 None
 1.33A 6ebpA-5csaA:
undetectable		 6ebpA-5csaA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5b FACT COMPLEX SUBUNIT
SPT16

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		5 LEU A 418
THR A 419
SER A 378
GLY A 404
ILE A 379
 None
 1.34A 6ebpA-5e5bA:
undetectable		 6ebpA-5e5bA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT DELTA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		5 LEU d 103
THR d 100
ILE d 450
PHE d 443
ILE d 508
 None
 1.35A 6ebpA-5gw5d:
2.4		 6ebpA-5gw5d:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcf CALRETICULIN,
PUTATIVE,CALRETICULI
N, PUTATIVE

(Trypanosoma
cruzi) 		PF00262
(Calreticulin) 		5 LEU A  67
THR A  68
SER A  51
ILE A  50
ILE A 327
 None
 1.16A 6ebpA-5hcfA:
undetectable		 6ebpA-5hcfA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA

(Geobacillus
stearothermophilus) 		no annotation 5 LEU B 242
THR B 310
GLY B 332
PHE B 286
ILE B 244
 None
 1.16A 6ebpA-5ivlB:
undetectable		 6ebpA-5ivlB:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy7 TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT BETA

(Homo sapiens) 		PF02186
(TFIIE_beta) 		5 LEU R  97
THR R  98
GLY R 135
ILE R 133
ILE R 130
 None
 1.04A 6ebpA-5iy7R:
undetectable		 6ebpA-5iy7R:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN

(Pyrococcus
abyssi) 		PF00005
(ABC_tran)
PF00037
(Fer4)
PF04068
(RLI) 		5 THR B 383
GLY B 378
ILE B 379
PHE B 356
ILE B 373
 None
 1.25A 6ebpA-5lw7B:
undetectable		 6ebpA-5lw7B:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucd NAD(P)-DEPENDENT
BENZALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 LEU A 127
THR A 128
GLY A 132
ILE A 134
ILE A 142
 None
 1.05A 6ebpA-5ucdA:
undetectable		 6ebpA-5ucdA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM6

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 LEU 6 552
SER 6 677
GLY 6 634
ILE 6 635
ILE 6 569
 None
 1.10A 6ebpA-5udb6:
undetectable		 6ebpA-5udb6:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukh UNCHARACTERIZED
PROTEIN

(Streptococcus
intermedius) 		no annotation 5 LEU A 272
SER A 279
GLY A 278
ILE A 277
ILE A 321
 None
 1.30A 6ebpA-5ukhA:
undetectable		 6ebpA-5ukhA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT

(Saccharomyces
cerevisiae) 		no annotation 5 LEU G 117
GLY G  67
ILE G  65
PHE G 224
ILE G  97
 None
 1.12A 6ebpA-5uz5G:
undetectable		 6ebpA-5uz5G:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wln TYPE II SECRETION
SYSTEM PROTEIN D

(Pseudomonas
aeruginosa) 		no annotation 5 THR G 309
SER G 268
GLY G 270
ILE G 267
ILE G 292
 None
 1.16A 6ebpA-5wlnG:
undetectable		 6ebpA-5wlnG:
7.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5y3x BETA-XYLANASE

(Caldicellulosiruptor
owensensis) 		no annotation 5 THR A 292
GLY A 211
ILE A 212
PHE A 180
ILE A 233
 None
 1.33A 6ebpA-5y3xA:
undetectable		 6ebpA-5y3xA:
40.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 382
ILE A 362
PHE A 350
PHE A 439
ILE A 419
 None
 1.31A 6ebpA-6az0A:
undetectable		 6ebpA-6az0A:
9.79