SIMILAR PATTERNS OF AMINO ACIDS FOR 6E8Q_A_X2NA602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN

(Escherichia
coli) 		PF04257
(Exonuc_V_gamma) 		4 TYR C 190
LEU C 313
TYR C 312
PRO C 220
 None
 1.33A 6e8qA-1w36C:
0.3		 6e8qA-1w36C:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		4 TYR A  64
LEU A 121
TYR A 132
PRO A 230
 None
X2N  A 590 (-4.6A)
HEM  A 580 (-4.1A)
X2N  A 590 (-4.2A)
 0.37A 6e8qA-5fsaA:
57.2		 6e8qA-5fsaA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw7 GLUCOSIDASE YGJK

(Escherichia
coli) 		PF01204
(Trehalase) 		4 TYR A 604
LEU A 635
TYR A 701
PRO A 634
 None
 1.05A 6e8qA-5gw7A:
0.0		 6e8qA-5gw7A:
7.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		4 TYR A  72
LEU A 129
TYR A 140
PRO A 238
 None
None
HEM  A 601 (-4.3A)
None
 0.35A 6e8qA-5hs1A:
63.5		 6e8qA-5hs1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		4 TYR A  73
LEU A 130
TYR A 141
PRO A 239
 1YN  A 602 (-4.9A)
None
HEM  A 601 (-4.2A)
1YN  A 602 ( 4.8A)
 0.70A 6e8qA-5jlcA:
58.9		 6e8qA-5jlcA:
77.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzo UDP-GLUCOSE-GLYCOPRO
TEIN
GLUCOSYLTRANSFERASE-
LIKE PROTEIN

(Chaetomium
thermophilum) 		PF06427
(UDP-g_GGTase) 		4 TYR A1324
LEU A1351
TYR A1346
PRO A1355
 None
 1.43A 6e8qA-5mzoA:
0.1		 6e8qA-5mzoA:
5.11