SIMILAR PATTERNS OF AMINO ACIDS FOR 6E5Z_A_CCSA106_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 GLY A 301
GLY A 302
ILE A 341
ALA A 343
GLY A 340
 None
 1.07A 6e5zA-1bf2A:
undetectable		 6e5zA-1bf2A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7b CELLOBIOSE
DEHYDROGENASE

(Phanerochaete
chrysosporium) 		PF16010
(CDH-cyt) 		5 GLY A 132
GLY A 131
ASN A 129
ILE A 133
GLY A  62
 None
 1.02A 6e5zA-1d7bA:
undetectable		 6e5zA-1d7bA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II

(Synechocystis
sp. PCC 6803) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 347
GLY A 111
ALA A 169
HIS A 406
GLY A 402
 None
 1.01A 6e5zA-1e5mA:
undetectable		 6e5zA-1e5mA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g2i PROTEASE I

(Pyrococcus
horikoshii) 		PF01965
(DJ-1_PfpI) 		5 GLU A  15
GLY A  69
GLY A  70
ILE A  99
PRO A 103
 None
 0.47A 6e5zA-1g2iA:
26.4		 6e5zA-1g2iA:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ith HEMOGLOBIN (CYANO
MET)

(Urechis caupo) 		PF00042
(Globin) 		5 GLY A  80
GLY A  81
ASN A  82
ILE A   7
ALA A  78
 None
 1.09A 6e5zA-1ithA:
undetectable		 6e5zA-1ithA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l9y FEZ-1 B-LACTAMASE

(Fluoribacter
gormanii) 		PF00753
(Lactamase_B) 		5 GLY A 261
ASN A  84
ILE A 219
THR A 201
HIS A 116
 None
None
None
None
ZN  A   1 (-3.4A)
 1.10A 6e5zA-1l9yA:
undetectable		 6e5zA-1l9yA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1muu GDP-MANNOSE
6-DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 GLY A  12
GLY A   9
ILE A   5
ALA A  13
GLY A  28
 None
NAD  A1001 (-3.1A)
None
None
None
 1.05A 6e5zA-1muuA:
5.4		 6e5zA-1muuA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oai NUCLEAR RNA EXPORT
FACTOR

(Homo sapiens) 		PF03943
(TAP_C) 		5 GLY A 610
ILE A 612
ALA A 608
THR A 604
HIS A 605
 None
 0.97A 6e5zA-1oaiA:
undetectable		 6e5zA-1oaiA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi4 HYPOTHETICAL PROTEIN
YHBO

(Escherichia
coli) 		PF01965
(DJ-1_PfpI) 		5 GLU A  38
GLY A  94
GLY A  95
ILE A 124
PRO A 128
 None
 0.35A 6e5zA-1oi4A:
25.1		 6e5zA-1oi4A:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 GLY A 120
GLY A 121
ASN A 122
ILE A 119
GLY A 125
 None
 0.93A 6e5zA-1oi7A:
5.9		 6e5zA-1oi7A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 GLY A 120
GLY A 121
ILE A 119
THR A 186
GLY A 176
 None
 1.01A 6e5zA-1oi7A:
5.9		 6e5zA-1oi7A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ox8 STRINGENT STARVATION
PROTEIN B

(Escherichia
coli) 		PF04386
(SspB) 		5 GLY A  99
ASN A  98
ILE A  93
ALA A  95
PRO A  28
 None
 1.05A 6e5zA-1ox8A:
undetectable		 6e5zA-1ox8A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Rhodospirillum
rubrum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 GLY A 298
GLY A 299
ASN A 300
ALA A 272
PRO A 271
 None
 1.06A 6e5zA-1ptjA:
2.4		 6e5zA-1ptjA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rty YVQK PROTEIN

(Bacillus
subtilis) 		PF01923
(Cob_adeno_trans) 		5 GLY A 115
GLY A 114
ILE A 173
ALA A 119
GLY A 174
 None
 1.11A 6e5zA-1rtyA:
undetectable		 6e5zA-1rtyA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru3 ACETYL-COA SYNTHASE

(Carboxydothermus
hydrogenoformans) 		PF03598
(CdhC) 		5 GLY A 613
ASN A 612
ALA A 725
PRO A 724
GLY A 665
 None
 1.02A 6e5zA-1ru3A:
6.8		 6e5zA-1ru3A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sbz PROBABLE AROMATIC
ACID DECARBOXYLASE

(Escherichia
coli) 		PF02441
(Flavoprotein) 		5 GLY A 104
GLY A 101
ILE A  94
ALA A  99
GLY A  93
 None
 1.10A 6e5zA-1sbzA:
6.0		 6e5zA-1sbzA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 GLY B  77
ASN B 109
ILE B  75
PRO B 233
GLY B  61
 None
 1.12A 6e5zA-1skyB:
undetectable		 6e5zA-1skyB:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twb STRINGENT STARVATION
PROTEIN B HOMOLOG

(Haemophilus
influenzae) 		PF04386
(SspB) 		5 GLY A  98
ASN A  97
ILE A  92
ALA A  94
PRO A  27
 None
 1.02A 6e5zA-1twbA:
undetectable		 6e5zA-1twbA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fex CONSERVED
HYPOTHETICAL PROTEIN

(Agrobacterium
fabrum) 		PF01965
(DJ-1_PfpI) 		6 GLU A  16
GLY A  71
GLY A  72
ILE A 100
ALA A 102
GLY A 155
 None
 0.31A 6e5zA-2fexA:
21.9		 6e5zA-2fexA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8o GERANYLTRANSTRANSFER
ASE

(Agrobacterium
fabrum) 		PF00348
(polyprenyl_synt) 		5 GLY A 102
GLY A 101
ILE A 236
ALA A  98
GLY A 233
 None
 1.12A 6e5zA-2h8oA:
undetectable		 6e5zA-2h8oA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE

(Crithidia
fasciculata) 		PF01156
(IU_nuc_hydro) 		5 GLY A 128
ASN A 131
ILE A 171
PRO A  70
GLY A  38
 None
 1.13A 6e5zA-2masA:
4.3		 6e5zA-2masA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA

(Vibrio cholerae) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		5 GLY A 302
GLY A 303
ILE A 295
HIS A 209
GLY A 182
 None
None
None
ZN  A 601 (-3.4A)
None
 1.04A 6e5zA-2nx9A:
undetectable		 6e5zA-2nx9A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odl ADHESIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		5 GLY A 215
GLY A 216
ASN A 258
ILE A 214
ALA A 235
 None
 1.12A 6e5zA-2odlA:
undetectable		 6e5zA-2odlA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p57 GTPASE-ACTIVATING
PROTEIN ZNF289

(Homo sapiens) 		PF01412
(ArfGap) 		5 GLY A  83
GLY A  84
ASN A  85
ILE A 118
ALA A  88
 None
 1.03A 6e5zA-2p57A:
undetectable		 6e5zA-2p57A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0x UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF08538
(DUF1749) 		5 GLU A  49
GLY A  45
GLY A 118
ALA A 114
HIS A 141
 None
 0.98A 6e5zA-2q0xA:
undetectable		 6e5zA-2q0xA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfr PURPLE ACID
PHOSPHATASE

(Phaseolus
vulgaris) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		5 GLY A 134
ILE A 359
ALA A 362
HIS A 389
GLY A 390
 None
 0.93A 6e5zA-2qfrA:
undetectable		 6e5zA-2qfrA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvx 4-CHLOROBENZOATE COA
LIGASE

(Alcaligenes sp.
AL3007) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 GLY X 303
ALA X 280
PRO X 252
THR X 283
GLY X 321
 3BZ  X 505 ( 3.9A)
3BZ  X 505 (-3.5A)
None
None
None
 1.14A 6e5zA-2qvxX:
2.5		 6e5zA-2qvxX:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r1v DJ-1

(Homo sapiens) 		PF01965
(DJ-1_PfpI) 		10 GLU A  18
GLY A  74
GLY A  75
ASN A  76
ILE A 105
ALA A 107
PRO A 109
THR A 125
HIS A 126
GLY A 157
 None
 0.23A 6e5zA-2r1vA:
39.7		 6e5zA-2r1vA:
99.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r1v DJ-1

(Homo sapiens) 		PF01965
(DJ-1_PfpI) 		6 GLU A  18
GLY A  75
ALA A 107
THR A 125
HIS A 126
GLY A 157
 None
 1.11A 6e5zA-2r1vA:
39.7		 6e5zA-2r1vA:
99.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf1 CAPSID PROTEIN

(Rabbit
picobirnavirus) 		no annotation 5 GLY A 468
ASN A 571
ILE A 472
ALA A 445
THR A 370
 None
 1.12A 6e5zA-2vf1A:
undetectable		 6e5zA-2vf1A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrn PROTEASE I

(Deinococcus
radiodurans) 		PF01965
(DJ-1_PfpI) 		5 GLU A  24
GLY A  83
GLY A  84
ILE A 114
PRO A 118
 CSO  A 115 ( 3.2A)
CSO  A 115 ( 4.0A)
CSO  A 115 ( 4.2A)
CSO  A 115 ( 3.6A)
CSO  A 115 ( 4.3A)
 0.29A 6e5zA-2vrnA:
25.9		 6e5zA-2vrnA:
29.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		5 GLU A 418
GLY A 200
ASN A 212
THR A 364
GLY A 395
 None
 1.10A 6e5zA-2x05A:
undetectable		 6e5zA-2x05A:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK) 		PF00202
(Aminotran_3) 		5 GLU A 220
GLY A 171
ASN A 178
ALA A 180
GLY A 224
 PLP  A1446 (-3.9A)
None
None
None
None
 1.01A 6e5zA-2ykyA:
3.0		 6e5zA-2ykyA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anv D-SERINE DEHYDRATASE

(Gallus gallus) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		5 GLY A  53
GLY A  52
ALA A  56
PRO A  42
GLY A  59
 None
 1.09A 6e5zA-3anvA:
undetectable		 6e5zA-3anvA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq2 6B PROTEIN

(Agrobacterium
vitis) 		PF02027
(RolB_RolC) 		5 GLY A  89
GLY A 160
ASN A 161
ALA A  87
GLY A 114
 None
 1.08A 6e5zA-3aq2A:
undetectable		 6e5zA-3aq2A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doj DEHYDROGENASE-LIKE
PROTEIN

(Arabidopsis
thaliana) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 GLY A 166
GLY A 164
ALA A 167
THR A  95
GLY A 118
 None
 1.14A 6e5zA-3dojA:
5.5		 6e5zA-3dojA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efe THIJ/PFPI FAMILY
PROTEIN

(Bacillus
anthracis) 		PF01965
(DJ-1_PfpI) 		5 GLU A  18
GLY A  80
GLY A  81
ILE A 109
GLY A 164
 None
 0.49A 6e5zA-3efeA:
19.8		 6e5zA-3efeA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5d PROTEIN YDEA

(Bacillus
subtilis) 		PF01965
(DJ-1_PfpI) 		5 GLU A  18
GLY A  71
GLY A  72
ILE A  99
GLY A 153
 None
 0.41A 6e5zA-3f5dA:
8.7		 6e5zA-3f5dA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg4 GLYCEROL KINASE

(Yersinia
pseudotuberculosis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 GLY A  77
GLY A   7
ALA A 482
THR A 486
GLY A  75
 None
 1.14A 6e5zA-3gg4A:
undetectable		 6e5zA-3gg4A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF03598
(CdhC) 		5 GLY A 610
ASN A 609
ALA A 722
PRO A 721
GLY A 662
 None
 1.12A 6e5zA-3gitA:
undetectable		 6e5zA-3gitA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF03598
(CdhC) 		5 GLY A 610
ASN A 609
ALA A 722
PRO A 721
GLY A 663
 None
 1.12A 6e5zA-3gitA:
undetectable		 6e5zA-3gitA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmu AMINOTRANSFERASE,
CLASS III

(Ruegeria
pomeroyi) 		PF00202
(Aminotran_3) 		5 GLY A 300
GLY A 301
ILE A 299
ALA A 120
GLY A 325
 None
 1.12A 6e5zA-3hmuA:
undetectable		 6e5zA-3hmuA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxk SUGAR HYDROLASE

(Lactococcus
lactis) 		PF00326
(Peptidase_S9) 		5 GLU A  61
GLY A  51
GLY A  52
ALA A 128
GLY A 232
 None
 0.93A 6e5zA-3hxkA:
4.2		 6e5zA-3hxkA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH

(Streptomyces
glaucescens) 		PF13416
(SBP_bac_8) 		5 GLU A 191
GLY A 190
GLY A 282
ALA A 278
PRO A 277
 None
 0.92A 6e5zA-3jzjA:
undetectable		 6e5zA-3jzjA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE

(Methanocaldococcus
jannaschii) 		PF02277
(DBI_PRT) 		5 GLY A 265
GLY A 321
ILE A 264
ALA A 237
GLY A 239
 None
 1.04A 6e5zA-3l0zA:
3.9		 6e5zA-3l0zA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ly5 ATP-DEPENDENT RNA
HELICASE DDX18

(Homo sapiens) 		PF00270
(DEAD) 		5 GLY A 253
ASN A 250
ILE A 304
THR A 281
HIS A 280
 None
 1.08A 6e5zA-3ly5A:
undetectable		 6e5zA-3ly5A:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mde MEDIUM CHAIN
ACYL-COA
DEHYDROGENASE

(Sus scrofa) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 GLY A 111
GLY A 112
ASN A 113
ILE A 247
GLY A 196
 None
 1.01A 6e5zA-3mdeA:
undetectable		 6e5zA-3mdeA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o14 ANTI-ECFSIGMA
FACTOR, CHRR

(Marinobacter
hydrocarbonoclasticus) 		PF12973
(Cupin_7) 		5 GLU A   2
GLY A  37
GLY A  38
ILE A  36
ALA A  41
 None
 1.12A 6e5zA-3o14A:
undetectable		 6e5zA-3o14A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		5 GLY B 599
GLY B 600
ASN B 602
PRO B 597
GLY B 858
 None
 1.07A 6e5zA-3o8oB:
4.2		 6e5zA-3o8oB:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqb OXIDOREDUCTASE

(Bradyrhizobium
diazoefficiens) 		PF01408
(GFO_IDH_MocA) 		5 GLY A 197
GLY A 196
ILE A 198
ALA A 243
THR A 226
 None
 0.92A 6e5zA-3oqbA:
6.2		 6e5zA-3oqbA:
19.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ot1 4-METHYL-5(B-HYDROXY
ETHYL)-THIAZOLE
MONOPHOSPHATE
BIOSYNTHESIS ENZYME

(Vibrio cholerae) 		PF01965
(DJ-1_PfpI) 		8 GLU B  21
GLY B  76
GLY B  77
ILE B 107
ALA B 109
PRO B 111
HIS B 129
GLY B 159
 CSX  B 108 ( 3.0A)
CSX  B 108 ( 3.2A)
CSX  B 108 (-3.4A)
CSX  B 108 ( 3.4A)
CSX  B 108 ( 3.7A)
CSX  B 108 ( 4.2A)
CSX  B 108 ( 4.3A)
CSX  B 108 ( 3.6A)
 0.34A 6e5zA-3ot1B:
30.5		 6e5zA-3ot1B:
39.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2y ALANINE
DEHYDROGENASE/PYRIDI
NE NUCLEOTIDE
TRANSHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 GLY A 285
GLY A 286
ASN A 287
ALA A 259
PRO A 258
 None
 1.04A 6e5zA-3p2yA:
4.1		 6e5zA-3p2yA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p40 NEUROFASCIN

(Homo sapiens) 		PF13927
(Ig_3) 		5 GLY A 362
ASN A 363
ALA A 335
HIS A 414
GLY A 415
 None
 1.14A 6e5zA-3p40A:
undetectable		 6e5zA-3p40A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 GLY B  70
GLY B  71
ILE B 143
THR B 145
GLY B  48
 None
 1.04A 6e5zA-3pcoB:
undetectable		 6e5zA-3pcoB:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae) 		PF08659
(KR) 		5 GLY A 387
GLY A 388
ALA A 383
THR A 398
GLY A 156
 None
 0.98A 6e5zA-3qp9A:
3.5		 6e5zA-3qp9A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Roseovarius sp.
TM1035) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 288
GLY A 289
ILE A  91
ALA A 287
GLY A  92
 None
 0.97A 6e5zA-3rcyA:
undetectable		 6e5zA-3rcyA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1u RNA
POLYMERASE-ASSOCIATE
D PROTEIN RTF1
HOMOLOG

(Homo sapiens) 		PF03126
(Plus-3) 		5 GLY A 407
ILE A 405
ALA A 379
THR A 381
GLY A 384
 None
None
None
UNX  A 512 ( 4.0A)
UNX  A 506 ( 4.5A)
 1.11A 6e5zA-3u1uA:
undetectable		 6e5zA-3u1uA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vdy SINGLE-STRANDED
DNA-BINDING PROTEIN
SSBB

(Bacillus
subtilis) 		PF00436
(SSB) 		5 GLY A   9
ASN A  34
ALA A  32
THR A  12
GLY A  68
 None
 0.99A 6e5zA-3vdyA:
undetectable		 6e5zA-3vdyA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zj0 ACETYLTRANSFERASE

(Oceanicola
granulosus) 		PF00583
(Acetyltransf_1) 		5 GLY A  43
ILE A  45
ALA A  47
PRO A  49
HIS A 135
 None
None
None
None
ACO  A1205 (-3.1A)
 0.74A 6e5zA-3zj0A:
undetectable		 6e5zA-3zj0A:
27.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu0 NAD NUCLEOTIDASE

(Haemophilus
influenzae) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 GLU A 287
GLY A 249
ALA A  92
HIS A  41
GLY A 288
 None
 1.08A 6e5zA-3zu0A:
undetectable		 6e5zA-3zu0A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0k DNA DAMAGE-BINDING
PROTEIN 2

(Danio rerio) 		PF00400
(WD40) 		5 GLY D 170
GLY D 169
ALA D 194
THR D 196
GLY D 166
 None
 1.09A 6e5zA-4a0kD:
undetectable		 6e5zA-4a0kD:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		5 GLY A 500
GLY A 498
ILE A 376
ALA A 502
GLY A 373
 None
 1.12A 6e5zA-4av6A:
undetectable		 6e5zA-4av6A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 GLY A 381
GLY A 380
ASN A 379
ILE A 382
ALA A 372
 None
 1.03A 6e5zA-4b9yA:
undetectable		 6e5zA-4b9yA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Sinorhizobium
meliloti) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 GLY A 322
GLY A 323
ASN A 324
ALA A 296
PRO A 295
 None
 1.01A 6e5zA-4dioA:
5.8		 6e5zA-4dioA:
20.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e08 DJ-1 BETA

(Drosophila
melanogaster) 		PF01965
(DJ-1_PfpI) 		7 GLU A  17
GLY A  72
GLY A  73
ILE A 103
ALA A 105
PRO A 107
GLY A 154
 None
 0.23A 6e5zA-4e08A:
35.2		 6e5zA-4e08A:
52.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f21 CARBOXYLESTERASE/PHO
SPHOLIPASE FAMILY
PROTEIN

(Francisella
tularensis) 		PF02230
(Abhydrolase_2) 		5 GLY A 119
GLY A 114
ILE A 120
ALA A 122
THR A 125
 None
 1.10A 6e5zA-4f21A:
4.1		 6e5zA-4f21A:
23.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ge0 UNCHARACTERIZED
PROTEIN C22E12.03C

(Schizosaccharomyces
pombe) 		PF01965
(DJ-1_PfpI) 		8 GLU A  16
GLY A  78
GLY A  79
ILE A 110
ALA A 112
PRO A 114
HIS A 130
GLY A 160
 None
 0.31A 6e5zA-4ge0A:
28.7		 6e5zA-4ge0A:
33.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcj THIJ/PFPI DOMAIN
PROTEIN

(Brachyspira
murdochii) 		PF01965
(DJ-1_PfpI) 		5 GLU A  20
GLY A  74
GLY A  75
ILE A 104
GLY A 155
 None
 0.54A 6e5zA-4hcjA:
26.6		 6e5zA-4hcjA:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE

(Yersinia pestis) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 GLY A 464
GLY A 353
ILE A 468
ALA A 465
GLY A 469
 None
AMP  A 501 (-3.5A)
None
None
None
 1.07A 6e5zA-4hv4A:
2.5		 6e5zA-4hv4A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxn OCTAPRENYL-DIPHOSPHA
TE SYNTHASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		5 GLY A 192
GLY A 191
ALA A  64
HIS A  66
GLY A  69
 None
 0.85A 6e5zA-4jxnA:
undetectable		 6e5zA-4jxnA:
23.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k2h INTRACELLULAR
PROTEASE/AMIDASE

(Salmonella
enterica) 		PF01965
(DJ-1_PfpI) 		5 GLU A  16
GLY A  71
GLY A  72
ILE A 102
GLY A 152
 None
 0.40A 6e5zA-4k2hA:
30.0		 6e5zA-4k2hA:
31.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 GLY B 604
GLY B 603
THR B 453
HIS B 663
GLY B 600
 None
 1.00A 6e5zA-4l37B:
undetectable		 6e5zA-4l37B:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lz6 BH2163 PROTEIN

(Bacillus
halodurans) 		PF01554
(MatE) 		5 GLY A 197
GLY A 194
ILE A 200
ALA A 198
THR A 202
 None
 0.98A 6e5zA-4lz6A:
undetectable		 6e5zA-4lz6A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ng4 PHOSPHOGLYCERATE
KINASE

(Coxiella
burnetii) 		PF00162
(PGK) 		5 GLY A 217
GLY A 218
ASN A 222
ILE A 215
ALA A 221
 None
ADP  A 402 (-3.2A)
ADP  A 402 (-3.9A)
None
None
 1.12A 6e5zA-4ng4A:
4.7		 6e5zA-4ng4A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofx CYSTATHIONINE
BETA-SYNTHASE

(Coxiella
burnetii) 		PF00291
(PALP) 		5 GLY A  77
GLY A  47
ILE A  76
ALA A  81
GLY A  39
 None
 1.04A 6e5zA-4ofxA:
undetectable		 6e5zA-4ofxA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio
cholerae;
Vibrio cholerae) 		PF02508
(Rnf-Nqr)
PF02508
(Rnf-Nqr) 		5 GLY E 184
ILE E 181
ALA E 183
THR E 179
GLY D 192
 None
 1.11A 6e5zA-4p6vE:
undetectable		 6e5zA-4p6vE:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe6 PUTATIVE ABC
TRANSPORTER

(Thermobispora
bispora) 		PF13407
(Peripla_BP_4) 		5 GLU A 265
GLY A 219
GLY A 247
ALA A 222
GLY A 243
 None
 1.11A 6e5zA-4pe6A:
5.6		 6e5zA-4pe6A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)

(Agrobacterium
vitis) 		PF01547
(SBP_bac_1) 		5 GLY A 399
GLY A 397
ILE A 193
ALA A 401
GLY A 188
 None
 1.10A 6e5zA-4ryaA:
undetectable		 6e5zA-4ryaA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9e DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE

(Escherichia
coli) 		PF01966
(HD) 		5 GLY A 189
GLY A 120
ASN A 121
ILE A 209
HIS A 117
 None
None
None
None
MG  A1000 (-3.5A)
 0.90A 6e5zA-4x9eA:
undetectable		 6e5zA-4x9eA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeb GLUCANASE

(Talaromyces
funiculosus) 		PF00840
(Glyco_hydro_7) 		5 GLY A 241
GLY A 251
ALA A 239
THR A 237
GLY A 204
 None
 1.11A 6e5zA-4xebA:
undetectable		 6e5zA-4xebA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xll DJ-1 FAMILY PROTEIN

(Toxoplasma
gondii) 		PF01965
(DJ-1_PfpI) 		7 GLU A  17
GLY A  72
GLY A  73
ILE A 103
ALA A 105
PRO A 107
GLY A 153
 None
 0.28A 6e5zA-4xllA:
31.9		 6e5zA-4xllA:
37.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ams RIBOSOME ASSEMBLY
PROTEIN SQT1

(Saccharomyces
cerevisiae) 		no annotation 5 GLY A 292
GLY A 291
ASN A 290
ILE A 244
ALA A 293
 None
 1.12A 6e5zA-5amsA:
undetectable		 6e5zA-5amsA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djq CBB3-TYPE CYTOCHROME
C OXIDASE SUBUNIT
CCON1

(Pseudomonas
stutzeri) 		PF00115
(COX1) 		5 GLY A 447
ILE A 443
ALA A 388
THR A 392
GLY A 441
 None
None
None
None
HEM  A 502 (-3.5A)
 0.98A 6e5zA-5djqA:
undetectable		 6e5zA-5djqA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fad RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE

(Sulfolobus
islandicus) 		PF13847
(Methyltransf_31) 		5 GLY A  40
GLY A  38
ILE A  43
ALA A  68
GLY A  57
 None
SAH  A 201 (-3.5A)
None
None
None
 1.14A 6e5zA-5fadA:
4.2		 6e5zA-5fadA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF09334
(tRNA-synt_1g) 		5 GLY A 667
GLY A 666
ILE A 795
THR A 797
GLY A 658
 None
 1.02A 6e5zA-5gl7A:
undetectable		 6e5zA-5gl7A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gol CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		no annotation 5 GLY A  17
ASN A  16
ALA A 129
PRO A 128
GLY A  69
 None
 1.07A 6e5zA-5golA:
undetectable		 6e5zA-5golA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gol CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		no annotation 5 GLY A  17
ASN A  16
ALA A 129
PRO A 128
GLY A  70
 None
 1.12A 6e5zA-5golA:
undetectable		 6e5zA-5golA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lir SIGMA CROSS-REACTING
PROTEIN 27A
(SCRP-27A)

(Salmonella
enterica) 		PF01965
(DJ-1_PfpI) 		5 GLU A  24
GLY A  96
GLY A  97
ILE A 137
PRO A 141
 CSO  A 138 ( 2.9A)
CSO  A 138 ( 3.6A)
CSO  A 138 ( 3.8A)
CSO  A 138 ( 3.9A)
CSO  A 138 ( 4.1A)
 0.51A 6e5zA-5lirA:
18.8		 6e5zA-5lirA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m45 ACETONE CARBOXYLASE
BETA SUBUNIT

(Xanthobacter
autotrophicus) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		5 GLY B 268
GLY B 269
ILE B 287
ALA B 265
GLY B 288
 None
 1.12A 6e5zA-5m45B:
undetectable		 6e5zA-5m45B:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nny WIPB

(Legionella
pneumophila) 		no annotation 5 GLU A 119
GLY A 152
ILE A 146
HIS A 231
GLY A 117
 None
 0.97A 6e5zA-5nnyA:
undetectable		 6e5zA-5nnyA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocl ANTI-LLAMA NANOBODY
ANTI-VGLUT NANOBODY

(Vicugna pacos;
Lama glama) 		PF07686
(V-set)
PF07686
(V-set) 		5 GLY A  35
GLY B  57
ASN B  59
ILE A  36
ALA A  54
 None
 0.86A 6e5zA-5oclA:
undetectable		 6e5zA-5oclA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol2 ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile) 		no annotation 5 GLU C  61
GLY C  60
GLY C  59
ALA C 114
GLY C  48
 None
 1.07A 6e5zA-5ol2C:
undetectable		 6e5zA-5ol2C:
20.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5sy4 CHAPERONE YAJL

(Escherichia
coli) 		PF01965
(DJ-1_PfpI) 		7 GLU A  17
GLY A  74
GLY A  75
ILE A 105
ALA A 107
PRO A 109
GLY A 157
 None
 0.33A 6e5zA-5sy4A:
31.6		 6e5zA-5sy4A:
42.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thz CURJ

(Moorea
producens) 		no annotation 5 GLY B 299
GLY B 300
ALA B 297
PRO B   2
HIS B 268
 None
 1.03A 6e5zA-5thzB:
3.4		 6e5zA-5thzB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txw PEPTIDASE

(Thermococcus
thioreducens) 		PF01965
(DJ-1_PfpI) 		5 GLU A  15
GLY A  69
GLY A  70
ILE A  99
PRO A 103
 OCS  A 100 ( 2.4A)
OCS  A 100 ( 3.0A)
OCS  A 100 ( 3.7A)
OCS  A 100 ( 3.7A)
OCS  A 100 ( 4.3A)
 0.41A 6e5zA-5txwA:
26.3		 6e5zA-5txwA:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u08 AAC3-I

(uncultured
bacterium) 		PF00583
(Acetyltransf_1) 		5 GLY A  70
GLY A  71
ILE A 103
ALA A  93
GLY A 104
 None
None
ACT  A 203 ( 4.8A)
None
ACT  A 203 (-3.7A)
 1.01A 6e5zA-5u08A:
undetectable		 6e5zA-5u08A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgt SINGLE-STRANDED
DNA-BINDING PROTEIN

(Staphylococcus
aureus) 		PF00436
(SSB) 		5 GLY A   9
ASN A  34
ALA A  32
THR A  12
GLY A  68
 None
 1.03A 6e5zA-5xgtA:
undetectable		 6e5zA-5xgtA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yyu -

(-) 		no annotation 5 GLY A   9
ASN A  34
ALA A  32
THR A  12
GLY A  68
 None
 0.97A 6e5zA-5yyuA:
undetectable		 6e5zA-5yyuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B

(Pyrococcus
furiosus) 		no annotation 5 GLY F  21
ILE F  27
ALA F  25
THR F  29
GLY F  41
 None
 1.13A 6e5zA-6cfwF:
undetectable		 6e5zA-6cfwF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k POLYSULPHIDE
REDUCTASE NRFD

(Rhodothermus
marinus) 		no annotation 6 GLY C 279
ILE C  95
ALA C  98
THR C 125
HIS C  97
GLY C  94
 None
 1.25A 6e5zA-6f0kC:
undetectable		 6e5zA-6f0kC:
undetectable