SIMILAR PATTERNS OF AMINO ACIDS FOR 6DYO_A_LDPA901_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aog TRYPANOTHIONE
REDUCTASE

(Trypanosoma
cruzi) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLU A 379
VAL A 391
LEU A 393
THR A 234
 None
 1.20A 6dyoA-1aogA:
0.0		 6dyoA-1aogA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0z PROTEIN
(PHOSPHOGLUCOSE
ISOMERASE)

(Geobacillus
stearothermophilus) 		PF00342
(PGI) 		4 GLU A 321
VAL A 312
HIS A 306
THR A 364
 None
 1.18A 6dyoA-1b0zA:
0.8		 6dyoA-1b0zA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		4 VAL A 318
LEU A 320
HIS A 203
THR A 519
 None
 1.25A 6dyoA-1cu1A:
0.0		 6dyoA-1cu1A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0t PYRUVATE KINASE

(Escherichia
coli) 		PF00224
(PK)
PF02887
(PK_C) 		4 VAL A 415
LEU A 409
HIS A 216
THR A 378
 None
None
None
SO4  A 701 (-3.4A)
 1.03A 6dyoA-1e0tA:
0.0		 6dyoA-1e0tA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		4 GLU A 244
VAL A 241
LEU A 236
THR A 489
 None
None
None
FAD  A1031 (-4.2A)
 1.45A 6dyoA-1h7wA:
0.3		 6dyoA-1h7wA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hwn EBULIN

(Sambucus ebulus) 		PF00161
(RIP) 		4 GLU A 235
VAL A 230
LEU A 220
THR A 240
 None
 1.47A 6dyoA-1hwnA:
0.0		 6dyoA-1hwnA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5o CPI-17

(Sus scrofa) 		PF05361
(PP1_inhibitor) 		4 VAL A  74
LEU A  77
HIS A  85
THR A   4
 None
 1.41A 6dyoA-1k5oA:
undetectable		 6dyoA-1k5oA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khw RNA-DIRECTED RNA
POLYMERASE

(Rabbit
hemorrhagic
disease virus) 		PF00680
(RdRP_1) 		4 GLU A 455
VAL A 458
LEU A 496
THR A 228
 None
 1.47A 6dyoA-1khwA:
0.0		 6dyoA-1khwA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lgf P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		4 GLU A 356
VAL A 151
LEU A 152
HIS A 171
 None
 1.10A 6dyoA-1lgfA:
0.0		 6dyoA-1lgfA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mbm CHYMOTRYPSIN-LIKE
SERINE PROTEASE

(Equine
arteritis virus) 		PF05579
(Peptidase_S32) 		4 GLU A 109
VAL A 158
LEU A 163
THR A  90
 None
 1.37A 6dyoA-1mbmA:
0.0		 6dyoA-1mbmA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsv GALACTOSE MUTAROTASE

(Lactococcus
lactis) 		PF01263
(Aldose_epim) 		4 GLU A 312
VAL A  77
LEU A  86
THR A  68
 None
 1.07A 6dyoA-1nsvA:
undetectable		 6dyoA-1nsvA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o70 FASCICLIN I

(Drosophila
melanogaster) 		PF02469
(Fasciclin) 		4 VAL A 622
LEU A 617
HIS A 543
THR A 516
 None
 1.13A 6dyoA-1o70A:
undetectable		 6dyoA-1o70A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ose PORCINE
ALPHA-AMYLASE

(Sus scrofa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 GLU A 272
VAL A 265
LEU A 277
HIS A 331
 BGC  A 996 (-2.7A)
None
None
None
 1.48A 6dyoA-1oseA:
undetectable		 6dyoA-1oseA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oz9 HYPOTHETICAL PROTEIN
AQ_1354

(Aquifex
aeolicus) 		PF02130
(UPF0054) 		4 VAL A  69
LEU A 112
HIS A 103
THR A  93
 None
 1.49A 6dyoA-1oz9A:
undetectable		 6dyoA-1oz9A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1roe FERREDOXIN

(Synechococcus
elongatus) 		PF00111
(Fer2) 		4 GLU A  56
VAL A  28
LEU A  34
THR A  90
 None
 1.44A 6dyoA-1roeA:
undetectable		 6dyoA-1roeA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1toa PROTEIN (PERIPLASMIC
BINDING PROTEIN
TROA)

(Treponema
pallidum) 		PF01297
(ZnuA) 		4 GLU A 212
VAL A 194
LEU A 242
HIS A 268
 None
 1.12A 6dyoA-1toaA:
undetectable		 6dyoA-1toaA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2c DYSTROGLYCAN

(Mus musculus) 		no annotation 4 GLU A 157
VAL A 226
LEU A 255
HIS A 296
 None
 1.02A 6dyoA-1u2cA:
undetectable		 6dyoA-1u2cA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 GLU A 286
VAL A 469
HIS A 316
THR A 348
 None
 1.27A 6dyoA-1w99A:
undetectable		 6dyoA-1w99A:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bgs ALDOSE REDUCTASE

(Hordeum vulgare) 		PF00248
(Aldo_ket_red) 		4 GLU A 221
VAL A 294
LEU A 295
HIS A 121
 None
None
NDP  A1321 (-4.8A)
BCT  A1322 ( 3.9A)
 1.19A 6dyoA-2bgsA:
undetectable		 6dyoA-2bgsA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF11941
(DUF3459) 		4 GLU A 421
VAL A 417
LEU A 411
HIS A 331
 TRS  A1603 (-2.6A)
TRS  A1603 (-4.0A)
None
None
 1.45A 6dyoA-2bxyA:
undetectable		 6dyoA-2bxyA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ee3 COLLAGEN ALPHA-1(XX)
CHAIN

(Homo sapiens) 		PF00041
(fn3) 		4 VAL A  26
LEU A  64
HIS A  49
THR A  53
 None
 1.19A 6dyoA-2ee3A:
undetectable		 6dyoA-2ee3A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Pyrococcus
furiosus) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 VAL A 298
LEU A  47
HIS A  83
THR A 117
 None
 1.46A 6dyoA-2i14A:
undetectable		 6dyoA-2i14A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy0 COMPLEMENT C1R
SUBCOMPONENT

(Homo sapiens) 		PF00089
(Trypsin) 		4 VAL B 523
LEU B 487
HIS B 467
THR B 482
 None
 1.38A 6dyoA-2qy0B:
undetectable		 6dyoA-2qy0B:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wda PUTATIVE SECRETED
LYASE

(Streptomyces
violaceoruber) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 VAL A 668
LEU A 530
HIS A 409
THR A 634
 MG  A1783 (-4.2A)
None
None
None
 1.42A 6dyoA-2wdaA:
undetectable		 6dyoA-2wdaA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtz UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--2,6-DIAMINOPIMELA
TE LIGASE

(Mycobacterium
tuberculosis) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 VAL A 231
LEU A 226
HIS A 252
THR A 152
 None
None
None
KCX  A 262 ( 3.6A)
 1.32A 6dyoA-2wtzA:
undetectable		 6dyoA-2wtzA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Bacillus
subtilis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 GLU A  83
VAL A  89
LEU A 312
THR A 265
 None
 1.25A 6dyoA-2xd4A:
undetectable		 6dyoA-2xd4A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwg SORTASE

(Actinomyces
oris) 		PF04203
(Sortase) 		4 GLU A 248
VAL A 244
LEU A 277
HIS A 198
 None
 1.44A 6dyoA-2xwgA:
undetectable		 6dyoA-2xwgA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yb4 AMIDOHYDROLASE

(Chromobacterium
violaceum) 		PF02811
(PHP) 		4 GLU A 218
VAL A 188
LEU A  79
THR A  37
 None
 1.10A 6dyoA-2yb4A:
1.8		 6dyoA-2yb4A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anx SPERMIDINE SYNTHASE

(Thermus
thermophilus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 GLU A   9
VAL A  11
LEU A 232
HIS A 226
 None
 1.50A 6dyoA-3anxA:
2.8		 6dyoA-3anxA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ci0 PSEUDOPILIN GSPI
PSEUDOPILIN GSPJ
PSEUDOPILIN GSPK

(Escherichia
coli;
Escherichia
coli;
Escherichia
coli) 		PF02501
(T2SSI)
PF11612
(T2SSJ)
PF03934
(T2SSK) 		4 GLU I  45
LEU K  41
HIS K 310
THR J  52
 None
 1.30A 6dyoA-3ci0I:
undetectable		 6dyoA-3ci0I:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnv PUTATIVE GNTR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Bordetella
bronchiseptica) 		PF07702
(UTRA) 		4 GLU A 220
VAL A 219
LEU A 248
HIS A 251
 None
 1.43A 6dyoA-3cnvA:
undetectable		 6dyoA-3cnvA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcy REGULATOR PROTEIN

(Homo sapiens) 		PF00300
(His_Phos_1) 		4 VAL A  49
LEU A  46
HIS A 262
THR A   7
 None
 1.07A 6dyoA-3dcyA:
undetectable		 6dyoA-3dcyA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1s EXODEOXYRIBONUCLEASE
V, SUBUNIT RECD

(Deinococcus
radiodurans) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30)
PF14490
(HHH_4) 		4 GLU A 378
VAL A 384
LEU A 386
THR A 401
 None
 1.22A 6dyoA-3e1sA:
undetectable		 6dyoA-3e1sA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eq2 PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR

(Pseudomonas
aeruginosa) 		PF00072
(Response_reg)
PF07228
(SpoIIE) 		4 VAL A 221
LEU A 224
HIS A 253
THR A 261
 None
 1.39A 6dyoA-3eq2A:
undetectable		 6dyoA-3eq2A:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff1 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Staphylococcus
aureus) 		PF00342
(PGI) 		4 GLU A 321
VAL A 312
HIS A 306
THR A 364
 None
 1.15A 6dyoA-3ff1A:
undetectable		 6dyoA-3ff1A:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbc CHOLOYLGLYCINE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF02275
(CBAH) 		4 VAL A  38
LEU A  32
HIS A 240
THR A 176
 None
 1.19A 6dyoA-3hbcA:
undetectable		 6dyoA-3hbcA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hij DIHYDRODIPICOLINATE
SYNTHASE

(Bacillus
anthracis) 		PF00701
(DHDPS) 		4 VAL A 132
LEU A 104
HIS A 120
THR A  91
 None
 1.13A 6dyoA-3hijA:
undetectable		 6dyoA-3hijA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsi PHOSPHATIDYLSERINE
SYNTHASE

(Haemophilus
influenzae) 		PF13091
(PLDc_2) 		4 GLU A 133
VAL A 137
LEU A  55
HIS A 361
 None
 1.24A 6dyoA-3hsiA:
undetectable		 6dyoA-3hsiA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE

(Bacillus
anthracis) 		PF00342
(PGI) 		4 GLU A 327
VAL A 318
HIS A 312
THR A 370
 None
 1.13A 6dyoA-3ifsA:
undetectable		 6dyoA-3ifsA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iic CHEC DOMAIN PROTEIN

(Shewanella
loihica) 		PF13690
(CheX) 		4 VAL A 118
LEU A  45
HIS A 128
THR A  93
 None
 1.37A 6dyoA-3iicA:
undetectable		 6dyoA-3iicA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js8 CHOLESTEROL OXIDASE

(Chromobacterium
sp. DS-1) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		4 VAL A  42
LEU A 206
HIS A 201
THR A  84
 None
FAD  A 541 (-4.8A)
FAD  A 541 (-4.2A)
FAD  A 541 ( 4.5A)
 1.30A 6dyoA-3js8A:
undetectable		 6dyoA-3js8A:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6r PUTATIVE TRANSFERASE
PH0793

(Pyrococcus
horikoshii) 		PF02475
(Met_10) 		4 GLU A 127
VAL A 129
LEU A 197
HIS A 224
 None
 1.50A 6dyoA-3k6rA:
undetectable		 6dyoA-3k6rA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA

(Archaeoglobus
fulgidus) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 GLU A  10
VAL A  18
LEU A  48
THR A   3
 None
 1.07A 6dyoA-3mm5A:
undetectable		 6dyoA-3mm5A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE

(Caulobacter
vibrioides) 		PF00348
(polyprenyl_synt) 		4 GLU A 176
VAL A 173
LEU A 169
HIS A 165
 None
 1.39A 6dyoA-3oyrA:
undetectable		 6dyoA-3oyrA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q48 CHAPERONE CUPB2

(Pseudomonas
aeruginosa) 		PF00345
(PapD_N)
PF02753
(PapD_C) 		4 GLU A 111
VAL A 152
HIS A 242
THR A 181
 None
 1.38A 6dyoA-3q48A:
undetectable		 6dyoA-3q48A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2h BACTERIOFERRITIN

(Pseudomonas
aeruginosa) 		PF00210
(Ferritin) 		4 GLU A  18
VAL A  96
LEU A  92
HIS A  77
 NA  A 156 (-2.8A)
None
CXS  A 155 ( 4.1A)
CXS  A 155 (-4.1A)
 1.38A 6dyoA-3r2hA:
undetectable		 6dyoA-3r2hA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3su8 PLEXIN-B1

(Homo sapiens) 		PF08337
(Plexin_cytopl) 		4 VAL X2070
LEU X2074
HIS X1646
THR X1697
 None
 1.12A 6dyoA-3su8X:
undetectable		 6dyoA-3su8X:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr2 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Coxiella
burnetii) 		PF00215
(OMPdecase) 		4 GLU A 164
VAL A 143
HIS A  90
THR A 123
 None
 1.45A 6dyoA-3tr2A:
undetectable		 6dyoA-3tr2A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umv DEOXYRIBODIPYRIMIDIN
E PHOTO-LYASE

(Oryza sativa) 		PF00875
(DNA_photolyase) 		4 GLU A 232
VAL A 229
LEU A 225
THR A 115
 EDO  A 708 ( 4.4A)
None
URE  A 903 (-4.5A)
None
 1.41A 6dyoA-3umvA:
undetectable		 6dyoA-3umvA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uow GMP SYNTHETASE

(Plasmodium
falciparum) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 GLU A 213
VAL A 211
LEU A  21
THR A 512
 None
 1.00A 6dyoA-3uowA:
undetectable		 6dyoA-3uowA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLU A 355
VAL A 400
LEU A 402
HIS A 433
 NAG  A 612 (-4.3A)
None
None
None
 1.29A 6dyoA-3v9eA:
undetectable		 6dyoA-3v9eA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wad GLYCOSYLTRANSFERASE

(Streptomyces
halstedii) 		PF06722
(DUF1205) 		4 VAL A 148
LEU A 206
HIS A 226
THR A 405
 None
 1.48A 6dyoA-3wadA:
undetectable		 6dyoA-3wadA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0f CD81 ANTIGEN

(Mus musculus) 		no annotation 4 VAL A 147
LEU A 131
HIS A 191
THR A 167
 None
IPA  A 303 ( 3.7A)
None
IPA  A 303 ( 4.1A)
 1.50A 6dyoA-3x0fA:
undetectable		 6dyoA-3x0fA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5

(Homo sapiens) 		PF07719
(TPR_2)
PF13181
(TPR_8)
PF13374
(TPR_10)
PF13424
(TPR_12) 		4 GLU A 448
VAL A 444
LEU A 404
HIS A 376
 None
 1.38A 6dyoA-3zgqA:
undetectable		 6dyoA-3zgqA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aov ISOCITRATE
DEHYDROGENASE [NADP]

(Desulfotalea
psychrophila) 		PF00180
(Iso_dh) 		4 VAL A  20
LEU A  21
HIS A 305
THR A 321
 None
None
NAP  A1403 (-3.7A)
None
 1.13A 6dyoA-4aovA:
undetectable		 6dyoA-4aovA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0t PUP--PROTEIN LIGASE

(Corynebacterium
glutamicum) 		PF03136
(Pup_ligase) 		4 GLU A 131
VAL A 222
LEU A 152
THR A 241
 None
 1.24A 6dyoA-4b0tA:
undetectable		 6dyoA-4b0tA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx9 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 33A

(Homo sapiens) 		PF00995
(Sec1) 		4 GLU A  22
VAL A  19
LEU A  15
THR A 181
 None
None
None
FMT  A1596 ( 4.0A)
 1.38A 6dyoA-4bx9A:
undetectable		 6dyoA-4bx9A:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 GLU A 156
VAL A 260
LEU A 256
THR A 185
 None
 1.37A 6dyoA-4dxyA:
undetectable		 6dyoA-4dxyA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eps HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF13149
(Mfa_like_1) 		4 GLU A 241
VAL A 187
LEU A 185
HIS A 181
 None
 1.41A 6dyoA-4epsA:
undetectable		 6dyoA-4epsA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hr1 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
abyssi virus 1) 		no annotation 4 GLU B  89
VAL B  93
LEU B  96
THR B 107
 None
 1.16A 6dyoA-4hr1B:
undetectable		 6dyoA-4hr1B:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6j F-BOX/LRR-REPEAT
PROTEIN 3

(Homo sapiens) 		PF12937
(F-box-like) 		4 GLU B 262
VAL B 260
LEU B 295
THR B 267
 None
 1.28A 6dyoA-4i6jB:
undetectable		 6dyoA-4i6jB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ina SACCHAROPINE
DEHYDROGENASE

(Wolinella
succinogenes) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 GLU A  74
VAL A  75
LEU A   5
THR A  58
 None
 1.10A 6dyoA-4inaA:
undetectable		 6dyoA-4inaA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg1 PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D

(Homo sapiens) 		PF10294
(Methyltransf_16) 		4 GLU A  73
VAL A  81
LEU A  53
HIS A  64
 SAM  A 301 ( 4.9A)
None
None
None
 1.45A 6dyoA-4lg1A:
undetectable		 6dyoA-4lg1A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oic PROBABLE PROTEIN
PHOSPHATASE 2C 6

(Oryza sativa) 		PF00481
(PP2C) 		4 GLU B 145
VAL B 147
LEU B 149
HIS B 409
 None
 1.31A 6dyoA-4oicB:
undetectable		 6dyoA-4oicB:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oq1 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		no annotation 4 GLU A 222
VAL A 250
LEU A 153
THR A 202
 None
 1.46A 6dyoA-4oq1A:
undetectable		 6dyoA-4oq1A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxd 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE,
PUTATIVE

(Entamoeba
histolytica) 		PF00459
(Inositol_P) 		4 VAL A 229
LEU A 225
HIS A 258
THR A 129
 None
 1.32A 6dyoA-4qxdA:
undetectable		 6dyoA-4qxdA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT
PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT

(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 GLU S  75
LEU S  25
HIS L 122
THR S  47
 SF4  S2001 ( 4.7A)
None
None
None
 1.02A 6dyoA-4u9iS:
undetectable		 6dyoA-4u9iS:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x28 ACYL-COA
DEHYDROGENASE
ACYL-COA
DEHYDROGENASE

(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
no annotation 		4 GLU A 382
VAL D 264
LEU D 268
THR D 324
 FDA  A 501 (-2.8A)
None
None
None
 1.45A 6dyoA-4x28A:
undetectable		 6dyoA-4x28A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Oceanimonas
doudoroffii) 		PF00171
(Aldedh) 		4 GLU A  89
VAL A  22
LEU A  34
HIS A   6
 None
 1.47A 6dyoA-4zz7A:
undetectable		 6dyoA-4zz7A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4

(Saccharomyces
cerevisiae) 		PF01793
(Glyco_transf_15) 		4 GLU A 352
VAL A 354
LEU A 359
HIS A 248
 None
 1.03A 6dyoA-5a08A:
undetectable		 6dyoA-5a08A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1q U14 PROTEIN

(Human
betaherpesvirus
6B) 		PF04637
(Herpes_pp85) 		4 GLU A  35
VAL A  36
LEU A  78
THR A 323
 None
 1.13A 6dyoA-5b1qA:
undetectable		 6dyoA-5b1qA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		4 GLU A 678
LEU A 685
HIS A 625
THR A 587
 None
 1.23A 6dyoA-5cslA:
undetectable		 6dyoA-5cslA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddv 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Bacillus
subtilis) 		PF01128
(IspD) 		4 GLU A 117
VAL A 201
LEU A 130
HIS A 103
 None
 1.18A 6dyoA-5ddvA:
undetectable		 6dyoA-5ddvA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fby SEPARASE
CLEAVED PEPTIDE

(Chaetomium
thermophilum;
synthetic
construct) 		PF03568
(Peptidase_C50)
no annotation 		4 VAL A1958
LEU B  16
HIS B  10
THR A1731
 None
 1.46A 6dyoA-5fbyA:
undetectable		 6dyoA-5fbyA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gin C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT

(Sulfolobus
solfataricus) 		PF01798
(Nop) 		4 GLU A  70
VAL A  65
LEU A   6
THR A  51
 None
 1.25A 6dyoA-5ginA:
undetectable		 6dyoA-5ginA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5goo ALKALINE INVERTASE

(Nostoc sp. PCC
7120) 		PF12899
(Glyco_hydro_100) 		4 GLU A 111
VAL A 104
LEU A 113
HIS A  84
 None
 1.29A 6dyoA-5gooA:
undetectable		 6dyoA-5gooA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwn PROTEIN RCC2

(Homo sapiens) 		PF00415
(RCC1) 		4 VAL A 332
LEU A 275
HIS A 288
THR A 342
 None
 1.43A 6dyoA-5gwnA:
undetectable		 6dyoA-5gwnA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I

(Geobacillus
stearothermophilus) 		PF01654
(Cyt_bd_oxida_I) 		4 VAL A 135
LEU A 132
HIS A 128
THR A  58
 None
 1.26A 6dyoA-5ir6A:
undetectable		 6dyoA-5ir6A:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
KINETOCHORE-ASSOCIAT
ED PROTEIN DSN1
HOMOLOG

(Homo sapiens;
Homo sapiens;
Homo sapiens) 		PF05859
(Mis12)
PF03980
(Nnf1)
PF08202
(MIS13) 		4 GLU A 141
VAL B 166
LEU B 167
THR D 270
 None
 1.32A 6dyoA-5lskA:
undetectable		 6dyoA-5lskA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE

(Streptomyces
violaceusniger) 		PF04820
(Trp_halogenase) 		4 GLU A  95
VAL A 124
LEU A 501
HIS A 137
 None
 1.47A 6dyoA-5lv9A:
undetectable		 6dyoA-5lv9A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndx GLYCOSYL HYDROLASE

(Rhizobium
leguminosarum) 		no annotation 4 VAL A 426
LEU A 512
HIS A 496
THR A 520
 None
 1.48A 6dyoA-5ndxA:
undetectable		 6dyoA-5ndxA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhu MYCINAMICIN IV
HYDROXYLASE/EPOXIDAS
E

(Micromonospora
griseorubida) 		PF00067
(p450) 		4 GLU A  71
VAL A  79
LEU A  84
HIS A  91
 None
MIV  A 402 (-3.1A)
HEM  A 401 (-3.4A)
HEM  A 401 (-3.9A)
 1.36A 6dyoA-5uhuA:
undetectable		 6dyoA-5uhuA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn4 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE

(Trypanosoma
brucei) 		PF00156
(Pribosyltran) 		4 GLU A 171
VAL A 201
LEU A   3
HIS A   0
 None
 1.28A 6dyoA-5vn4A:
undetectable		 6dyoA-5vn4A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx4 ALKYLQUINOLONE
SYNTHASE

(Tetradium
ruticarpum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 GLU A  39
VAL A  71
LEU A 337
HIS A 309
 None
 1.37A 6dyoA-5wx4A:
undetectable		 6dyoA-5wx4A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x87 BESTROPHIN

(Klebsiella
pneumoniae) 		no annotation 4 GLU A 144
VAL A 147
LEU A 138
HIS A 127
 None
 1.49A 6dyoA-5x87A:
undetectable		 6dyoA-5x87A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 4 VAL A 289
LEU A 281
HIS A 273
THR A 342
 None
 1.45A 6dyoA-6ccfA:
undetectable		 6dyoA-6ccfA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN

(Idiomarina sp.
A28L) 		no annotation 4 GLU A 388
VAL A 384
LEU A 363
HIS A 341
 None
 1.42A 6dyoA-6et7A:
undetectable		 6dyoA-6et7A:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fai SERINE/THREONINE-PRO
TEIN KINASE RIO2

(Saccharomyces
cerevisiae) 		no annotation 4 VAL l  94
LEU l  85
HIS l 185
THR l   5
 None
 1.28A 6dyoA-6fail:
undetectable		 6dyoA-6fail:
22.68