SIMILAR PATTERNS OF AMINO ACIDS FOR 6DYN_A_HSMA901_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aog TRYPANOTHIONE
REDUCTASE

(Trypanosoma
cruzi) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLU A 379
VAL A 391
LEU A 393
THR A 234
 None
 1.13A 6dynA-1aogA:
0.0		 6dynA-1aogA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hwn EBULIN

(Sambucus ebulus) 		PF00161
(RIP) 		4 GLU A 235
VAL A 230
LEU A 220
THR A 240
 None
 1.43A 6dynA-1hwnA:
0.0		 6dynA-1hwnA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khw RNA-DIRECTED RNA
POLYMERASE

(Rabbit
hemorrhagic
disease virus) 		PF00680
(RdRP_1) 		4 GLU A 455
VAL A 458
LEU A 496
THR A 228
 None
 1.46A 6dynA-1khwA:
0.0		 6dynA-1khwA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mbm CHYMOTRYPSIN-LIKE
SERINE PROTEASE

(Equine
arteritis virus) 		PF05579
(Peptidase_S32) 		4 GLU A 109
VAL A 158
LEU A 163
THR A  90
 None
 1.32A 6dynA-1mbmA:
0.0		 6dynA-1mbmA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsv GALACTOSE MUTAROTASE

(Lactococcus
lactis) 		PF01263
(Aldose_epim) 		4 GLU A 312
VAL A  77
LEU A  86
THR A  68
 None
 1.09A 6dynA-1nsvA:
0.0		 6dynA-1nsvA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Bacillus
subtilis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 GLU A  83
VAL A  89
LEU A 312
THR A 265
 None
 1.27A 6dynA-2xd4A:
0.0		 6dynA-2xd4A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yb4 AMIDOHYDROLASE

(Chromobacterium
violaceum) 		PF02811
(PHP) 		4 GLU A 218
VAL A 188
LEU A  79
THR A  37
 None
 1.09A 6dynA-2yb4A:
0.0		 6dynA-2yb4A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1s EXODEOXYRIBONUCLEASE
V, SUBUNIT RECD

(Deinococcus
radiodurans) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30)
PF14490
(HHH_4) 		4 GLU A 378
VAL A 384
LEU A 386
THR A 401
 None
 1.19A 6dynA-3e1sA:
0.4		 6dynA-3e1sA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA

(Archaeoglobus
fulgidus) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 GLU A  10
VAL A  18
LEU A  48
THR A   3
 None
 1.10A 6dynA-3mm5A:
0.0		 6dynA-3mm5A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umv DEOXYRIBODIPYRIMIDIN
E PHOTO-LYASE

(Oryza sativa) 		PF00875
(DNA_photolyase) 		4 GLU A 232
VAL A 229
LEU A 225
THR A 115
 EDO  A 708 ( 4.4A)
None
URE  A 903 (-4.5A)
None
 1.42A 6dynA-3umvA:
undetectable		 6dynA-3umvA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uow GMP SYNTHETASE

(Plasmodium
falciparum) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 GLU A 213
VAL A 211
LEU A  21
THR A 512
 None
 1.00A 6dynA-3uowA:
undetectable		 6dynA-3uowA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx9 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 33A

(Homo sapiens) 		PF00995
(Sec1) 		4 GLU A  22
VAL A  19
LEU A  15
THR A 181
 None
None
None
FMT  A1596 ( 4.0A)
 1.37A 6dynA-4bx9A:
undetectable		 6dynA-4bx9A:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhn NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		4 GLU B1042
VAL B1069
LEU B1073
THR B1081
 None
 1.01A 6dynA-4fhnB:
undetectable		 6dynA-4fhnB:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6j F-BOX/LRR-REPEAT
PROTEIN 3

(Homo sapiens) 		PF12937
(F-box-like) 		4 GLU B 262
VAL B 260
LEU B 295
THR B 267
 None
 1.30A 6dynA-4i6jB:
undetectable		 6dynA-4i6jB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ina SACCHAROPINE
DEHYDROGENASE

(Wolinella
succinogenes) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 GLU A  74
VAL A  75
LEU A   5
THR A  58
 None
 1.11A 6dynA-4inaA:
undetectable		 6dynA-4inaA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oq1 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		no annotation 4 GLU A 222
VAL A 250
LEU A 153
THR A 202
 None
 1.46A 6dynA-4oq1A:
undetectable		 6dynA-4oq1A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gin C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT

(Sulfolobus
solfataricus) 		PF01798
(Nop) 		4 GLU A  70
VAL A  65
LEU A   6
THR A  51
 None
 1.19A 6dynA-5ginA:
undetectable		 6dynA-5ginA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
KINETOCHORE-ASSOCIAT
ED PROTEIN DSN1
HOMOLOG

(Homo sapiens;
Homo sapiens;
Homo sapiens) 		PF05859
(Mis12)
PF03980
(Nnf1)
PF08202
(MIS13) 		4 GLU A 141
VAL B 166
LEU B 167
THR D 270
 None
 1.29A 6dynA-5lskA:
undetectable		 6dynA-5lskA:
18.05