SIMILAR PATTERNS OF AMINO ACIDS FOR 6DWN_D_AQ4D602_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a0c | XYLOSE ISOMERASE (Thermoanaerobacteriumthermosulfurigenes) |
PF01261(AP_endonuc_2) | 5 | ILE A 92PHE A 23PHE A 43GLY A 358ALA A 357 | None | 1.00A | 6dwnD-1a0cA:undetectable | 6dwnD-1a0cA:11.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a0c | XYLOSE ISOMERASE (Thermoanaerobacteriumthermosulfurigenes) |
PF01261(AP_endonuc_2) | 5 | ILE A 92PHE A 43GLY A 358ALA A 357ASP A 360 | None | 0.89A | 6dwnD-1a0cA:undetectable | 6dwnD-1a0cA:11.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1atg | PERIPLASMICMOLYBDATE-BINDINGPROTEIN (Azotobactervinelandii) |
PF13531(SBP_bac_11) | 5 | ILE A 223ASN A 10PHE A 11ALA A 195LEU A 15 | NoneWO4 A 250 ( 3.7A)NoneNoneNone | 1.03A | 6dwnD-1atgA:0.0 | 6dwnD-1atgA:17.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bou | 4,5-DIOXYGENASE BETACHAIN (Sphingomonaspaucimobilis) |
PF02900(LigB) | 5 | ILE B 106PHE B 115GLY B 169ALA B 252ASP B 170 | None | 1.11A | 6dwnD-1bouB:0.0 | 6dwnD-1bouB:14.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dnp | DNA PHOTOLYASE (Escherichiacoli) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 5 | GLY A 266ALA A 262ASP A 264ILE A 276LEU A 158 | None | 1.09A | 6dwnD-1dnpA:0.0 | 6dwnD-1dnpA:9.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fl2 | ALKYL HYDROPEROXIDEREDUCTASE SUBUNIT F (Escherichiacoli) |
PF07992(Pyr_redox_2) | 5 | SER A 508GLY A 235ALA A 232ASP A 281ILE A 217 | None | 1.11A | 6dwnD-1fl2A:0.0 | 6dwnD-1fl2A:14.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fts | FTSY (Escherichiacoli) |
PF00448(SRP54)PF02881(SRP54_N) | 5 | ILE A 457GLY A 424ALA A 427ASP A 420ILE A 443 | None | 1.12A | 6dwnD-1ftsA:undetectable | 6dwnD-1ftsA:13.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kz1 | 6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE (Schizosaccharomycespombe) |
PF00885(DMRL_synthase) | 5 | ILE A 84ASN A 141GLY A 147ALA A 149ASP A 145 | None | 1.10A | 6dwnD-1kz1A:0.0 | 6dwnD-1kz1A:23.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ltm | 36 KDA SOLUBLE LYTICTRANSGLYCOSYLASE (Escherichiacoli) |
PF13406(SLT_2) | 5 | PHE A 199ASP A 176ALA A 179ILE A 81LEU A 200 | None | 0.91A | 6dwnD-1ltmA:undetectable | 6dwnD-1ltmA:15.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1odf | HYPOTHETICAL 33.3KDA PROTEIN INADE3-SER2 INTERGENICREGION (Saccharomycescerevisiae) |
no annotation | 5 | ILE A 202PHE A 35GLY A 164PHE A 259LEU A 158 | None | 1.07A | 6dwnD-1odfA:0.0 | 6dwnD-1odfA:13.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q3s | THERMOSOME ALPHASUBUNIT (Thermococcussp. JCM 11816) |
PF00118(Cpn60_TCP1) | 5 | ASP A 519GLY A 21ALA A 24ASP A 23ILE A 522 | None | 1.08A | 6dwnD-1q3sA:undetectable | 6dwnD-1q3sA:10.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rzv | GLYCOGEN SYNTHASE 1 (Agrobacteriumtumefaciens) |
PF00534(Glycos_transf_1)PF08323(Glyco_transf_5) | 5 | ILE A 41SER A 5GLY A 24ASP A 21LEU A 19 | None | 1.09A | 6dwnD-1rzvA:undetectable | 6dwnD-1rzvA:10.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s4c | PROTEIN HI0227 (Haemophilusinfluenzae) |
PF04074(DUF386) | 5 | ILE A 81PHE A 124GLY A 84ALA A 85ILE A 3 | None | 1.05A | 6dwnD-1s4cA:undetectable | 6dwnD-1s4cA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vme | FLAVOPROTEIN (Thermotogamaritima) |
PF00258(Flavodoxin_1) | 5 | ILE A 15PHE A 165ALA A 42ASP A 55ILE A 231 | None | 1.07A | 6dwnD-1vmeA:undetectable | 6dwnD-1vmeA:11.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vpb | PUTATIVE MODULATOROF DNA GYRASE (Bacteroidesthetaiotaomicron) |
PF01523(PmbA_TldD) | 5 | ILE A 309ASN A 272GLY A 313ALA A 276LEU A 267 | None | 1.03A | 6dwnD-1vpbA:undetectable | 6dwnD-1vpbA:10.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wza | ALPHA-AMYLASE A (Halothermothrixorenii) |
PF00128(Alpha-amylase) | 5 | ILE A 351GLY A 295ALA A 294ILE A 289LEU A 338 | None | 1.02A | 6dwnD-1wzaA:undetectable | 6dwnD-1wzaA:9.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xtt | PROBABLE URACILPHOSPHORIBOSYLTRANSFERASE (Sulfolobussolfataricus) |
PF14681(UPRTase) | 5 | PHE A 28GLY A 211ALA A 81ILE A 169LEU A 32 | NoneNoneU5P A1250 ( 3.7A)NoneNone | 1.04A | 6dwnD-1xttA:undetectable | 6dwnD-1xttA:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z9d | URIDYLATE KINASE (Streptococcuspyogenes) |
PF00696(AA_kinase) | 5 | SER A 15GLY A 21ALA A 20ASP A 28ILE A 53 | SO4 A1004 ( 3.1A)NoneNoneNoneNone | 1.09A | 6dwnD-1z9dA:undetectable | 6dwnD-1z9dA:15.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d7s | RNA-DEPENDENT RNAPOLYMERASE (Foot-and-mouthdisease virus) |
PF00680(RdRP_1) | 5 | ILE A 309SER A 213PHE A 199ILE A 211LEU A 89 | None | 1.04A | 6dwnD-2d7sA:undetectable | 6dwnD-2d7sA:11.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d92 | INAD-LIKE PROTEIN (Homo sapiens) |
PF00595(PDZ) | 5 | ILE A 32GLY A 29ALA A 57ILE A 101LEU A 99 | None | 0.94A | 6dwnD-2d92A:undetectable | 6dwnD-2d92A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h6o | MAJOR OUTER ENVELOPEGLYCOPROTEIN GP350 (Humangammaherpesvirus4) |
PF05109(Herpes_BLLF1) | 5 | PHE A 65GLY A 80ALA A 81ASP A 64ILE A 50 | NoneNoneNoneNAG A1047 (-4.6A)None | 1.10A | 6dwnD-2h6oA:undetectable | 6dwnD-2h6oA:11.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hgs | PROTEIN (GLUTATHIONESYNTHETASE) (Homo sapiens) |
PF03199(GSH_synthase)PF03917(GSH_synth_ATP) | 5 | ILE A 235ASP A 257GLY A 258ILE A 242LEU A 254 | None | 1.06A | 6dwnD-2hgsA:undetectable | 6dwnD-2hgsA:10.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hi4 | CYTOCHROME P450 1A2 (Homo sapiens) |
PF00067(p450) | 8 | ILE A 117PHE A 226ASP A 313GLY A 316ALA A 317ASP A 320ILE A 386LEU A 497 | NoneBHF A 800 (-3.6A)BHF A 800 (-3.9A)BHF A 800 (-3.8A)HEM A 900 ( 3.5A)BHF A 800 (-4.0A)HEM A 900 (-4.0A)BHF A 800 (-4.4A) | 0.48A | 6dwnD-2hi4A:55.0 | 6dwnD-2hi4A:81.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hi4 | CYTOCHROME P450 1A2 (Homo sapiens) |
PF00067(p450) | 5 | ILE A 117PHE A 226PHE A 260ASP A 320LEU A 497 | NoneBHF A 800 (-3.6A)BHF A 800 (-3.6A)BHF A 800 (-4.0A)BHF A 800 (-4.4A) | 1.01A | 6dwnD-2hi4A:55.0 | 6dwnD-2hi4A:81.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j1n | OUTER MEMBRANEPROTEIN C (Escherichiacoli) |
PF00267(Porin_1) | 5 | ILE A 294ASN A 324PHE A 326GLY A 331ASP A 329 | None | 0.95A | 6dwnD-2j1nA:undetectable | 6dwnD-2j1nA:12.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wpg | AMYLOSUCRASE ORALPHA AMYLASE (Xanthomonascampestris) |
PF00128(Alpha-amylase)PF11941(DUF3459) | 5 | ILE A 368PHE A 413GLY A 406ALA A 405LEU A 415 | None | 1.06A | 6dwnD-2wpgA:undetectable | 6dwnD-2wpgA:7.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x1g | CADMUS (Drosophilamelanogaster) |
PF03810(IBN_N)PF08389(Xpo1) | 6 | SER F 90PHE F 43GLY F 60ALA F 61ILE F 87LEU F 68 | None | 1.15A | 6dwnD-2x1gF:undetectable | 6dwnD-2x1gF:6.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ber | PROBABLEATP-DEPENDENT RNAHELICASE DDX47 (Homo sapiens) |
PF00270(DEAD) | 5 | PHE A 26GLY A 76ALA A 77ILE A 52LEU A 29 | AMP A 300 (-4.9A)NoneNoneNoneNone | 0.90A | 6dwnD-3berA:undetectable | 6dwnD-3berA:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3da1 | GLYCEROL-3-PHOSPHATEDEHYDROGENASE (Bacillushalodurans) |
PF01266(DAO)PF16901(DAO_C) | 5 | ILE A 367GLY A 391ALA A 389ILE A 33LEU A 21 | None | 1.10A | 6dwnD-3da1A:undetectable | 6dwnD-3da1A:8.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dbi | SUGAR-BINDINGTRANSCRIPTIONALREGULATOR, LACIFAMILY (Escherichiacoli) |
PF13377(Peripla_BP_3) | 5 | ILE A 184SER A 273GLY A 180ALA A 179ILE A 275 | None | 1.10A | 6dwnD-3dbiA:undetectable | 6dwnD-3dbiA:12.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3djd | FRUCTOSYL AMINE:OXYGENOXIDOREDUCTASE (Aspergillusfumigatus) |
PF01266(DAO) | 5 | ILE A 435GLY A 48ALA A 47PHE A 367LEU A 238 | NoneFAD A 500 (-3.9A)FAD A 500 (-3.2A)NoneNone | 1.11A | 6dwnD-3djdA:undetectable | 6dwnD-3djdA:10.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eh1 | PROTEIN TRANSPORTPROTEIN SEC24B (Homo sapiens) |
PF00626(Gelsolin)PF04810(zf-Sec23_Sec24)PF04811(Sec23_trunk)PF04815(Sec23_helical)PF08033(Sec23_BS) | 5 | ILE A1124PHE A1179GLY A1157ILE A1229LEU A1184 | None | 1.08A | 6dwnD-3eh1A:undetectable | 6dwnD-3eh1A:8.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eh1 | PROTEIN TRANSPORTPROTEIN SEC24B (Homo sapiens) |
PF00626(Gelsolin)PF04810(zf-Sec23_Sec24)PF04811(Sec23_trunk)PF04815(Sec23_helical)PF08033(Sec23_BS) | 5 | ILE A1169PHE A1179GLY A1157ASP A1176ILE A1192 | None | 0.91A | 6dwnD-3eh1A:undetectable | 6dwnD-3eh1A:8.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3es5 | PUTATIVE CAPSIDPROTEIN (Penicilliumstoloniferumvirus F) |
no annotation | 5 | ILE A 83GLY A 379ALA A 355ILE A 160LEU A 75 | None | 1.12A | 6dwnD-3es5A:undetectable | 6dwnD-3es5A:13.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fsg | ALPHA/BETASUPERFAMILYHYDROLASE (Oenococcus oeni) |
PF12697(Abhydrolase_6) | 5 | ILE A 210PHE A 208PHE A 261ALA A 100ILE A 121 | None | 1.10A | 6dwnD-3fsgA:undetectable | 6dwnD-3fsgA:15.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h5t | TRANSCRIPTIONALREGULATOR, LACIFAMILY (Corynebacteriumglutamicum) |
PF00356(LacI)PF13377(Peripla_BP_3) | 5 | ILE A 192SER A 299GLY A 188ALA A 187ASP A 186 | None | 1.05A | 6dwnD-3h5tA:undetectable | 6dwnD-3h5tA:12.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hbn | UDP-SUGAR HYDROLASE (Campylobacterjejuni) |
no annotation | 5 | SER A 173ASP A 168GLY A 166PHE A 15ILE A 188 | NoneNoneUDP A 301 (-3.5A)NoneNone | 1.08A | 6dwnD-3hbnA:undetectable | 6dwnD-3hbnA:10.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hn0 | NITRATE TRANSPORTPROTEIN (Parabacteroidesdistasonis) |
no annotation | 5 | SER A 255GLY A 249ALA A 250ILE A 37LEU A 240 | None | 1.00A | 6dwnD-3hn0A:undetectable | 6dwnD-3hn0A:15.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jr7 | UNCHARACTERIZED EGVFAMILY PROTEINCOG1307 ([Ruminococcus]gnavus) |
PF02645(DegV) | 5 | PHE A 32ASP A 59ALA A 46ASP A 27ILE A 49 | None | 1.10A | 6dwnD-3jr7A:undetectable | 6dwnD-3jr7A:13.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ka7 | OXIDOREDUCTASE (Methanosarcinamazei) |
PF01593(Amino_oxidase) | 5 | ASN A 377GLY A 411ALA A 413ILE A 198LEU A 10 | FAD A 500 ( 4.7A)NoneNoneNoneNone | 1.12A | 6dwnD-3ka7A:undetectable | 6dwnD-3ka7A:10.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kyj | PUTATIVE HISTIDINEPROTEIN KINASE (Rhodobactersphaeroides) |
PF01627(Hpt) | 5 | ILE A 90GLY A 83ALA A 82ASP A 81ILE A 131 | None | 1.04A | 6dwnD-3kyjA:undetectable | 6dwnD-3kyjA:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mwc | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Kosmotogaolearia) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ILE A 129GLY A 368ALA A 369PHE A 371ILE A 285 | None | 1.06A | 6dwnD-3mwcA:undetectable | 6dwnD-3mwcA:11.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3pm0 | CYTOCHROME P450 1B1 (Homo sapiens) |
PF00067(p450) | 6 | ASN A 228PHE A 231PHE A 268ASP A 326GLY A 329LEU A 509 | BHF A 800 (-4.2A)BHF A 800 (-3.4A)BHF A 800 ( 3.8A)BHF A 800 (-3.4A)BHF A 800 ( 4.0A)BHF A 800 (-4.7A) | 1.26A | 6dwnD-3pm0A:46.9 | 6dwnD-3pm0A:58.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3pm0 | CYTOCHROME P450 1B1 (Homo sapiens) |
PF00067(p450) | 8 | PHE A 231PHE A 268ASP A 326GLY A 329ALA A 330ASP A 333ILE A 399LEU A 509 | BHF A 800 (-3.4A)BHF A 800 ( 3.8A)BHF A 800 (-3.4A)BHF A 800 ( 4.0A)HEM A 900 ( 3.4A)BHF A 800 ( 4.1A)HEM A 900 (-4.0A)BHF A 800 (-4.7A) | 0.71A | 6dwnD-3pm0A:46.9 | 6dwnD-3pm0A:58.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rju | BETA-LACTAMASE/D-ALANINECARBOXYPEPTIDASE (Yersinia pestis) |
PF00144(Beta-lactamase) | 5 | SER A 228ASP A 232GLY A 189ILE A 226LEU A 180 | None | 1.07A | 6dwnD-3rjuA:undetectable | 6dwnD-3rjuA:13.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t33 | G PROTEIN COUPLEDRECEPTOR (Arabidopsisthaliana) |
PF05147(LANC_like) | 5 | ILE A 327PHE A 405GLY A 288ALA A 227ILE A 122 | None | 1.09A | 6dwnD-3t33A:undetectable | 6dwnD-3t33A:11.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v11 | TRANSLATIONINITIATION FACTOR 2SUBUNIT ALPHA (Sulfolobussolfataricus) |
PF00575(S1)PF07541(EIF_2_alpha) | 5 | ILE B 217ASN B 244GLY B 181ILE B 200LEU B 250 | None | 1.09A | 6dwnD-3v11B:undetectable | 6dwnD-3v11B:12.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wsy | SORTILIN-RELATEDRECEPTOR (Homo sapiens) |
PF15901(Sortilin_C)PF15902(Sortilin-Vps10) | 5 | ASN A 674ASP A 357GLY A 733ASP A 734LEU A 644 | NAG A 805 (-1.7A)NoneNoneNoneNone | 1.06A | 6dwnD-3wsyA:undetectable | 6dwnD-3wsyA:8.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wuf | ENDO-1,4-BETA-XYLANASE A (Streptomycessp.) |
PF00331(Glyco_hydro_10) | 5 | ILE A 308GLY A 293ALA A 294ASP A 291LEU A 244 | None | 1.09A | 6dwnD-3wufA:undetectable | 6dwnD-3wufA:14.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4av6 | K(+)-STIMULATEDPYROPHOSPHATE-ENERGIZED SODIUM PUMP (Thermotogamaritima) |
PF03030(H_PPase) | 5 | ILE A 186GLY A 239ALA A 238ILE A 92LEU A 50 | None | 1.10A | 6dwnD-4av6A:2.0 | 6dwnD-4av6A:7.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4duu | PLASMINOGEN (Homo sapiens) |
PF00024(PAN_1)PF00051(Kringle)PF00089(Trypsin) | 5 | SER A 203PHE A 227GLY A 199ALA A 675ASP A 676 | None | 0.97A | 6dwnD-4duuA:undetectable | 6dwnD-4duuA:8.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4euf | PUTATIVE REDUCTASECA_C0462 (Clostridiumacetobutylicum) |
PF07055(Eno-Rase_FAD_bd)PF12241(Enoyl_reductase)PF12242(Eno-Rase_NADH_b) | 5 | ILE A 309PHE A 313GLY A 63ILE A 45LEU A 134 | None | 1.07A | 6dwnD-4eufA:undetectable | 6dwnD-4eufA:10.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fe9 | OUTER MEMBRANEPROTEIN SUSF (Bacteroidesthetaiotaomicron) |
PF16411(SusF_SusE)PF17142(DUF5115) | 5 | ILE A 484PHE A 421GLY A 425ILE A 429LEU A 387 | None | 0.99A | 6dwnD-4fe9A:undetectable | 6dwnD-4fe9A:10.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ff5 | GLYCOSYL HYDROLASE25 (Streptococcuspneumoniae) |
PF01183(Glyco_hydro_25) | 6 | ILE A 214ASN A 224GLY A 54PHE A 240ILE A 43LEU A 34 | None | 1.23A | 6dwnD-4ff5A:undetectable | 6dwnD-4ff5A:13.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fj6 | GLYCOSIDE HYDROLASEFAMILY 33, CANDIDATESIALIDASE (Parabacteroidesdistasonis) |
PF13859(BNR_3)PF14873(BNR_assoc_N) | 5 | ILE A 70GLY A 62ALA A 158ILE A 32LEU A 41 | None | 1.06A | 6dwnD-4fj6A:undetectable | 6dwnD-4fj6A:10.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fk1 | PUTATIVE THIOREDOXINREDUCTASE (Bacillusanthracis) |
PF07992(Pyr_redox_2) | 5 | ILE C 227PHE C 131GLY C 224ILE C 199LEU C 202 | None | 0.99A | 6dwnD-4fk1C:undetectable | 6dwnD-4fk1C:17.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fs7 | UNCHARACTERIZEDPROTEIN (Bacteroidesovatus) |
PF13306(LRR_5) | 5 | ILE A 354PHE A 382PHE A 410ILE A 345LEU A 365 | None | 0.87A | 6dwnD-4fs7A:undetectable | 6dwnD-4fs7A:12.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fzv | PUTATIVEMETHYLTRANSFERASENSUN4 (Homo sapiens) |
PF01189(Methyltr_RsmB-F) | 5 | SER A 162PHE A 98ASP A 159GLY A 74PHE A 142 | None | 1.04A | 6dwnD-4fzvA:undetectable | 6dwnD-4fzvA:13.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gud | IMIDAZOLE GLYCEROLPHOSPHATE SYNTHASESUBUNIT HISH (Vibrio cholerae) |
PF00117(GATase) | 5 | PHE A 184GLY A 193ALA A 194ILE A 22LEU A 201 | None | 1.05A | 6dwnD-4gudA:undetectable | 6dwnD-4gudA:16.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hxt | DE NOVO PROTEINOR329 (syntheticconstruct) |
PF00514(Arm) | 5 | ILE A 71GLY A 44ALA A 43ASP A 42ILE A 29 | None | 1.07A | 6dwnD-4hxtA:undetectable | 6dwnD-4hxtA:14.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hxt | DE NOVO PROTEINOR329 (syntheticconstruct) |
PF00514(Arm) | 5 | ILE A 155GLY A 128ALA A 127ASP A 126ILE A 113 | None | 1.05A | 6dwnD-4hxtA:undetectable | 6dwnD-4hxtA:14.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hxt | DE NOVO PROTEINOR329 (syntheticconstruct) |
PF00514(Arm) | 5 | ILE A 197GLY A 170ALA A 169ASP A 168ILE A 155 | None | 1.06A | 6dwnD-4hxtA:undetectable | 6dwnD-4hxtA:14.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hxt | DE NOVO PROTEINOR329 (syntheticconstruct) |
PF00514(Arm) | 5 | ILE A 239GLY A 212ALA A 211ASP A 210ILE A 197 | None | 0.99A | 6dwnD-4hxtA:undetectable | 6dwnD-4hxtA:14.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4i8v | CYTOCHROME P450 1A1 (Homo sapiens) |
PF00067(p450) | 11 | ILE A 115SER A 122ASN A 222PHE A 224PHE A 258ASP A 313GLY A 316ALA A 317PHE A 319ILE A 386LEU A 496 | BHF A 602 (-4.7A)HEM A 601 (-3.4A)BHF A 602 ( 3.8A)BHF A 602 (-3.3A)BHF A 602 ( 3.9A)BHF A 602 (-3.7A)BHF A 602 (-3.5A)BHF A 602 ( 3.4A)BHF A 602 ( 4.7A)HEM A 601 (-3.6A)None | 0.78A | 6dwnD-4i8vA:59.1 | 6dwnD-4i8vA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4i8v | CYTOCHROME P450 1A1 (Homo sapiens) |
PF00067(p450) | 11 | ILE A 115SER A 122PHE A 224PHE A 258ASP A 313GLY A 316ALA A 317PHE A 319ASP A 320ILE A 386LEU A 496 | BHF A 602 (-4.7A)HEM A 601 (-3.4A)BHF A 602 (-3.3A)BHF A 602 ( 3.9A)BHF A 602 (-3.7A)BHF A 602 (-3.5A)BHF A 602 ( 3.4A)BHF A 602 ( 4.7A)BHF A 602 (-3.7A)HEM A 601 (-3.6A)None | 0.53A | 6dwnD-4i8vA:59.1 | 6dwnD-4i8vA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4i8v | CYTOCHROME P450 1A1 (Homo sapiens) |
PF00067(p450) | 6 | SER A 120PHE A 224ASP A 313GLY A 316PHE A 319ASP A 320 | BHF A 602 ( 4.5A)BHF A 602 (-3.3A)BHF A 602 (-3.7A)BHF A 602 (-3.5A)BHF A 602 ( 4.7A)BHF A 602 (-3.7A) | 1.42A | 6dwnD-4i8vA:59.1 | 6dwnD-4i8vA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jga | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Rickettsiarickettsii) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | ILE A 184GLY A 276ALA A 301ASP A 304ILE A 423 | None | 1.09A | 6dwnD-4jgaA:undetectable | 6dwnD-4jgaA:11.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4klk | PHAGE-RELATEDPROTEIN DUF2815 (Enterococcusfaecalis) |
PF10991(DUF2815) | 5 | ILE A 138PHE A 140ALA A 51ILE A 41LEU A 80 | None | 1.08A | 6dwnD-4klkA:undetectable | 6dwnD-4klkA:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kt1 | LEUCINE-RICHREPEAT-CONTAININGG-PROTEIN COUPLEDRECEPTOR 4 (Homo sapiens) |
PF01462(LRRNT)PF13516(LRR_6)PF13855(LRR_8) | 5 | ILE A 244GLY A 266ALA A 291ILE A 277LEU A 295 | None | 1.09A | 6dwnD-4kt1A:undetectable | 6dwnD-4kt1A:9.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l1n | CONSERVEDLIPOPROTEIN,PUTATIVE (Clostridiumnovyi) |
PF15525(DUF4652) | 5 | ILE A 115GLY A 126ALA A 172ILE A 169LEU A 145 | None | 1.10A | 6dwnD-4l1nA:undetectable | 6dwnD-4l1nA:17.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nk6 | POLY(BETA-D-MANNURONATE) C5 EPIMERASE (Pseudomonassyringae groupgenomosp. 3) |
PF13229(Beta_helix) | 5 | ILE A 281ASN A 311PHE A 286GLY A 258ILE A 203 | None | 1.11A | 6dwnD-4nk6A:undetectable | 6dwnD-4nk6A:9.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4okm | TERPENE SYNTHASEMETAL-BINDINGDOMAIN-CONTAININGPROTEIN (Streptomycespristinaespiralis) |
no annotation | 5 | ILE A 219SER A 12PHE A 297GLY A 300PHE A 55 | None | 1.08A | 6dwnD-4okmA:undetectable | 6dwnD-4okmA:12.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rv1 | ENGINEERED PROTEINOR497 (syntheticconstruct) |
PF00514(Arm) | 5 | ILE A 71GLY A 44ALA A 43ASP A 42ILE A 29 | None | 1.06A | 6dwnD-4rv1A:undetectable | 6dwnD-4rv1A:12.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rv1 | ENGINEERED PROTEINOR497 (syntheticconstruct) |
PF00514(Arm) | 5 | ILE A 281GLY A 254ALA A 253ASP A 252ILE A 239 | None | 1.10A | 6dwnD-4rv1A:undetectable | 6dwnD-4rv1A:12.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rv1 | ENGINEERED PROTEINOR497 (syntheticconstruct) |
PF00514(Arm) | 5 | ILE A 407GLY A 380ALA A 379ASP A 378ILE A 365 | None | 1.07A | 6dwnD-4rv1A:undetectable | 6dwnD-4rv1A:12.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rv7 | DIADENYLATE CYCLASE (Listeriamonocytogenes) |
PF02457(DisA_N) | 5 | ILE A 32PHE A 63GLY A 72ALA A 85ILE A 81 | NoneNoneATP A1001 (-3.3A)NoneNone | 1.10A | 6dwnD-4rv7A:undetectable | 6dwnD-4rv7A:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tmc | OLD YELLOW ENZYME (Kluyveromycesmarxianus) |
PF00724(Oxidored_FMN) | 5 | ILE A 166ASN A 207PHE A 201GLY A 160LEU A 197 | None | 1.11A | 6dwnD-4tmcA:undetectable | 6dwnD-4tmcA:12.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wia | PUTATIVEFLAGELLA-RELATEDPROTEIN H (Methanocaldococcusjannaschii) |
PF06745(ATPase) | 6 | SER A 28ASN A 54PHE A 51GLY A 23ILE A 30LEU A 47 | None | 1.39A | 6dwnD-4wiaA:undetectable | 6dwnD-4wiaA:17.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wp3 | MA1120 (Mycobacteriumavium) |
PF00211(Guanylate_cyc) | 5 | ILE A 194PHE A 196ALA A 187ASP A 186ILE A 146 | None | 1.09A | 6dwnD-4wp3A:undetectable | 6dwnD-4wp3A:17.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wp8 | MA1120 (Mycobacteriumavium) |
PF00211(Guanylate_cyc) | 5 | ILE A 194PHE A 196ALA A 187ASP A 186ILE A 146 | None | 1.06A | 6dwnD-4wp8A:undetectable | 6dwnD-4wp8A:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y0a | SHIKIMATE KINASE (Acinetobacterbaumannii) |
PF01202(SKI) | 5 | ILE A 61SER A 49PHE A 73GLY A 97ALA A 98 | SKM A 201 ( 4.0A)NoneSKM A 201 (-3.5A)SKM A 201 (-3.2A)None | 1.05A | 6dwnD-4y0aA:undetectable | 6dwnD-4y0aA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yu5 | IMMUNE INHIBITOR A,METALLOPROTEASE (Bacillus cereus) |
PF05547(Peptidase_M6) | 5 | ILE A 181PHE A 193GLY A 372ALA A 373PHE A 377 | None | 1.11A | 6dwnD-4yu5A:undetectable | 6dwnD-4yu5A:8.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z11 | AURONE SYNTHASE (Coreopsisgrandiflora) |
PF00264(Tyrosinase)PF12142(PPO1_DWL)PF12143(PPO1_KFDV) | 5 | ILE A 418PHE A 428GLY A 452ILE A 507LEU A 493 | None | 1.10A | 6dwnD-4z11A:undetectable | 6dwnD-4z11A:12.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zdn | AT-LESS POLYKETIDESYNTHASE (Streptomycesplatensis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | ILE A 859PHE A 881ASP A 884ILE A 979LEU A 846 | None | 1.09A | 6dwnD-4zdnA:undetectable | 6dwnD-4zdnA:9.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zpj | EXTRACELLULARLIGAND-BINDINGRECEPTOR (Sphaerobacterthermophilus) |
PF13458(Peripla_BP_6) | 5 | ILE A 81GLY A 112ALA A 111ASP A 109ILE A 374 | None | 1.10A | 6dwnD-4zpjA:undetectable | 6dwnD-4zpjA:11.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ao8 | SOLUBLE LYTICTRANGLYCOSILASE B3 (Pseudomonasaeruginosa) |
PF01471(PG_binding_1)PF13406(SLT_2) | 5 | ILE A 184ASN A 156GLY A 201ALA A 202ILE A 228 | NoneNoneNoneNAG A 999 ( 4.1A)None | 0.93A | 6dwnD-5ao8A:undetectable | 6dwnD-5ao8A:12.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5awp | ISOMALTODEXTRANASE (Arthrobacterglobiformis) |
no annotation | 5 | ASN A 214PHE A 156ASP A 197ILE A 80LEU A 165 | NoneGLC A 702 ( 4.9A)BGC A 701 (-3.0A)GLC A 702 (-4.1A)None | 0.92A | 6dwnD-5awpA:undetectable | 6dwnD-5awpA:8.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e38 | URACILPHOSPHORIBOSYLTRANSFERASE (Mycobacteriumtuberculosis) |
PF14681(UPRTase) | 5 | ASN A 25PHE A 28GLY A 200ALA A 78LEU A 32 | None | 1.04A | 6dwnD-5e38A:undetectable | 6dwnD-5e38A:17.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g5f | TAU CLASSGLUTATHIONES-TRANSFERASE (Mangiferaindica) |
PF00043(GST_C)PF02798(GST_N) | 5 | ILE A 137PHE A 163ALA A 194PHE A 197LEU A 170 | None | 1.03A | 6dwnD-5g5fA:undetectable | 6dwnD-5g5fA:15.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gt5 | PECTATE LYASE (Paenibacillussp. 0602) |
no annotation | 5 | ILE A 188PHE A 193GLY A 430ALA A 429ILE A 290 | None | 1.11A | 6dwnD-5gt5A:undetectable | 6dwnD-5gt5A:11.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hmp | UNCONVENTIONALMYOSIN-VC (Homo sapiens) |
PF00063(Myosin_head) | 5 | ILE A 158GLY A 432PHE A 430ILE A 436LEU A 635 | None | 1.03A | 6dwnD-5hmpA:undetectable | 6dwnD-5hmpA:7.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k8b | 8-AMINO-3,8-DIDEOXY-ALPHA-D-MANNO-OCTULOSONATE TRANSAMINASE (Shewanellaoneidensis) |
PF01041(DegT_DnrJ_EryC1) | 5 | ILE A 162PHE A 182GLY A 61ALA A 64ILE A 197 | NoneNonePDG A 501 (-3.4A)NoneNone | 1.02A | 6dwnD-5k8bA:undetectable | 6dwnD-5k8bA:12.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m1t | MUCRPHOSPHODIESTERASE (Pseudomonasaeruginosa) |
PF00563(EAL) | 5 | ILE A 612ASN A 664GLY A 637ALA A 635LEU A 661 | None | 1.11A | 6dwnD-5m1tA:undetectable | 6dwnD-5m1tA:15.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u7s | FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE (Acinetobacterbaumannii) |
PF01116(F_bP_aldolase) | 5 | ILE A 192PHE A 181GLY A 141ASP A 105LEU A 146 | None | 1.07A | 6dwnD-5u7sA:undetectable | 6dwnD-5u7sA:12.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w75 | ELONGATION FACTOR TU (Thermotoganeapolitana) |
no annotation | 5 | ILE A 93ALA A 376PHE A 331ILE A 61LEU A 312 | None | 1.11A | 6dwnD-5w75A:undetectable | 6dwnD-5w75A:25.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5way | TRANSCRIPTIONALACTIVATOR (Streptococcuspneumoniae) |
PF05043(Mga)PF08270(PRD_Mga)PF08280(HTH_Mga) | 5 | ILE A 143SER A 137PHE A 213GLY A 100ILE A 121 | None | 1.05A | 6dwnD-5wayA:undetectable | 6dwnD-5wayA:9.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wyp | DNA POLYMERASE IIISUBUNIT BETA (Caulobactervibrioides) |
no annotation | 5 | ILE A 323ASN A 258PHE A 346ILE A 296LEU A 262 | None | 0.94A | 6dwnD-5wypA:undetectable | 6dwnD-5wypA:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zya | SPLICING FACTOR 3BSUBUNIT 1 (Homo sapiens) |
no annotation | 5 | ILE C 872GLY C 880ALA C 881ASP C 883LEU C 888 | None | 1.05A | 6dwnD-5zyaC:undetectable | 6dwnD-5zyaC:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bhu | MULTIDRUGRESISTANCE-ASSOCIATED PROTEIN 1 (Bos taurus) |
no annotation | 5 | ILE A 726ASP A 757ASP A 749ILE A 761LEU A 768 | None | 1.04A | 6dwnD-6bhuA:undetectable | 6dwnD-6bhuA:0.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cuq | MACROPHAGE MIGRATIONINHIBITORYFACTOR-LIKE PROTEIN (Entamoebahistolytica) |
no annotation | 5 | ILE A 94GLY A 88ALA A 87ILE A 6LEU A 82 | None | 1.10A | 6dwnD-6cuqA:undetectable | 6dwnD-6cuqA:19.32 |