SIMILAR PATTERNS OF AMINO ACIDS FOR 6DWN_D_AQ4D602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0c XYLOSE ISOMERASE

(Thermoanaerobacterium
thermosulfurigenes)
PF01261
(AP_endonuc_2)
5 ILE A  92
PHE A  23
PHE A  43
GLY A 358
ALA A 357
None
1.00A 6dwnD-1a0cA:
undetectable
6dwnD-1a0cA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0c XYLOSE ISOMERASE

(Thermoanaerobacterium
thermosulfurigenes)
PF01261
(AP_endonuc_2)
5 ILE A  92
PHE A  43
GLY A 358
ALA A 357
ASP A 360
None
0.89A 6dwnD-1a0cA:
undetectable
6dwnD-1a0cA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1atg PERIPLASMIC
MOLYBDATE-BINDING
PROTEIN


(Azotobacter
vinelandii)
PF13531
(SBP_bac_11)
5 ILE A 223
ASN A  10
PHE A  11
ALA A 195
LEU A  15
None
WO4  A 250 ( 3.7A)
None
None
None
1.03A 6dwnD-1atgA:
0.0
6dwnD-1atgA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bou 4,5-DIOXYGENASE BETA
CHAIN


(Sphingomonas
paucimobilis)
PF02900
(LigB)
5 ILE B 106
PHE B 115
GLY B 169
ALA B 252
ASP B 170
None
1.11A 6dwnD-1bouB:
0.0
6dwnD-1bouB:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dnp DNA PHOTOLYASE

(Escherichia
coli)
PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
5 GLY A 266
ALA A 262
ASP A 264
ILE A 276
LEU A 158
None
1.09A 6dwnD-1dnpA:
0.0
6dwnD-1dnpA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fl2 ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F


(Escherichia
coli)
PF07992
(Pyr_redox_2)
5 SER A 508
GLY A 235
ALA A 232
ASP A 281
ILE A 217
None
1.11A 6dwnD-1fl2A:
0.0
6dwnD-1fl2A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fts FTSY

(Escherichia
coli)
PF00448
(SRP54)
PF02881
(SRP54_N)
5 ILE A 457
GLY A 424
ALA A 427
ASP A 420
ILE A 443
None
1.12A 6dwnD-1ftsA:
undetectable
6dwnD-1ftsA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kz1 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE


(Schizosaccharomyces
pombe)
PF00885
(DMRL_synthase)
5 ILE A  84
ASN A 141
GLY A 147
ALA A 149
ASP A 145
None
1.10A 6dwnD-1kz1A:
0.0
6dwnD-1kz1A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE


(Escherichia
coli)
PF13406
(SLT_2)
5 PHE A 199
ASP A 176
ALA A 179
ILE A  81
LEU A 200
None
0.91A 6dwnD-1ltmA:
undetectable
6dwnD-1ltmA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odf HYPOTHETICAL 33.3
KDA PROTEIN IN
ADE3-SER2 INTERGENIC
REGION


(Saccharomyces
cerevisiae)
no annotation 5 ILE A 202
PHE A  35
GLY A 164
PHE A 259
LEU A 158
None
1.07A 6dwnD-1odfA:
0.0
6dwnD-1odfA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3s THERMOSOME ALPHA
SUBUNIT


(Thermococcus
sp. JCM 11816)
PF00118
(Cpn60_TCP1)
5 ASP A 519
GLY A  21
ALA A  24
ASP A  23
ILE A 522
None
1.08A 6dwnD-1q3sA:
undetectable
6dwnD-1q3sA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzv GLYCOGEN SYNTHASE 1

(Agrobacterium
tumefaciens)
PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5)
5 ILE A  41
SER A   5
GLY A  24
ASP A  21
LEU A  19
None
1.09A 6dwnD-1rzvA:
undetectable
6dwnD-1rzvA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4c PROTEIN HI0227

(Haemophilus
influenzae)
PF04074
(DUF386)
5 ILE A  81
PHE A 124
GLY A  84
ALA A  85
ILE A   3
None
1.05A 6dwnD-1s4cA:
undetectable
6dwnD-1s4cA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vme FLAVOPROTEIN

(Thermotoga
maritima)
PF00258
(Flavodoxin_1)
5 ILE A  15
PHE A 165
ALA A  42
ASP A  55
ILE A 231
None
1.07A 6dwnD-1vmeA:
undetectable
6dwnD-1vmeA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpb PUTATIVE MODULATOR
OF DNA GYRASE


(Bacteroides
thetaiotaomicron)
PF01523
(PmbA_TldD)
5 ILE A 309
ASN A 272
GLY A 313
ALA A 276
LEU A 267
None
1.03A 6dwnD-1vpbA:
undetectable
6dwnD-1vpbA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wza ALPHA-AMYLASE A

(Halothermothrix
orenii)
PF00128
(Alpha-amylase)
5 ILE A 351
GLY A 295
ALA A 294
ILE A 289
LEU A 338
None
1.02A 6dwnD-1wzaA:
undetectable
6dwnD-1wzaA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE


(Sulfolobus
solfataricus)
PF14681
(UPRTase)
5 PHE A  28
GLY A 211
ALA A  81
ILE A 169
LEU A  32
None
None
U5P  A1250 ( 3.7A)
None
None
1.04A 6dwnD-1xttA:
undetectable
6dwnD-1xttA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9d URIDYLATE KINASE

(Streptococcus
pyogenes)
PF00696
(AA_kinase)
5 SER A  15
GLY A  21
ALA A  20
ASP A  28
ILE A  53
SO4  A1004 ( 3.1A)
None
None
None
None
1.09A 6dwnD-1z9dA:
undetectable
6dwnD-1z9dA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7s RNA-DEPENDENT RNA
POLYMERASE


(Foot-and-mouth
disease virus)
PF00680
(RdRP_1)
5 ILE A 309
SER A 213
PHE A 199
ILE A 211
LEU A  89
None
1.04A 6dwnD-2d7sA:
undetectable
6dwnD-2d7sA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d92 INAD-LIKE PROTEIN

(Homo sapiens)
PF00595
(PDZ)
5 ILE A  32
GLY A  29
ALA A  57
ILE A 101
LEU A  99
None
0.94A 6dwnD-2d92A:
undetectable
6dwnD-2d92A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6o MAJOR OUTER ENVELOPE
GLYCOPROTEIN GP350


(Human
gammaherpesvirus
4)
PF05109
(Herpes_BLLF1)
5 PHE A  65
GLY A  80
ALA A  81
ASP A  64
ILE A  50
None
None
None
NAG  A1047 (-4.6A)
None
1.10A 6dwnD-2h6oA:
undetectable
6dwnD-2h6oA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)


(Homo sapiens)
PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP)
5 ILE A 235
ASP A 257
GLY A 258
ILE A 242
LEU A 254
None
1.06A 6dwnD-2hgsA:
undetectable
6dwnD-2hgsA:
10.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens)
PF00067
(p450)
8 ILE A 117
PHE A 226
ASP A 313
GLY A 316
ALA A 317
ASP A 320
ILE A 386
LEU A 497
None
BHF  A 800 (-3.6A)
BHF  A 800 (-3.9A)
BHF  A 800 (-3.8A)
HEM  A 900 ( 3.5A)
BHF  A 800 (-4.0A)
HEM  A 900 (-4.0A)
BHF  A 800 (-4.4A)
0.48A 6dwnD-2hi4A:
55.0
6dwnD-2hi4A:
81.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens)
PF00067
(p450)
5 ILE A 117
PHE A 226
PHE A 260
ASP A 320
LEU A 497
None
BHF  A 800 (-3.6A)
BHF  A 800 (-3.6A)
BHF  A 800 (-4.0A)
BHF  A 800 (-4.4A)
1.01A 6dwnD-2hi4A:
55.0
6dwnD-2hi4A:
81.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1n OUTER MEMBRANE
PROTEIN C


(Escherichia
coli)
PF00267
(Porin_1)
5 ILE A 294
ASN A 324
PHE A 326
GLY A 331
ASP A 329
None
0.95A 6dwnD-2j1nA:
undetectable
6dwnD-2j1nA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE


(Xanthomonas
campestris)
PF00128
(Alpha-amylase)
PF11941
(DUF3459)
5 ILE A 368
PHE A 413
GLY A 406
ALA A 405
LEU A 415
None
1.06A 6dwnD-2wpgA:
undetectable
6dwnD-2wpgA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1g CADMUS

(Drosophila
melanogaster)
PF03810
(IBN_N)
PF08389
(Xpo1)
6 SER F  90
PHE F  43
GLY F  60
ALA F  61
ILE F  87
LEU F  68
None
1.15A 6dwnD-2x1gF:
undetectable
6dwnD-2x1gF:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ber PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX47


(Homo sapiens)
PF00270
(DEAD)
5 PHE A  26
GLY A  76
ALA A  77
ILE A  52
LEU A  29
AMP  A 300 (-4.9A)
None
None
None
None
0.90A 6dwnD-3berA:
undetectable
6dwnD-3berA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da1 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE


(Bacillus
halodurans)
PF01266
(DAO)
PF16901
(DAO_C)
5 ILE A 367
GLY A 391
ALA A 389
ILE A  33
LEU A  21
None
1.10A 6dwnD-3da1A:
undetectable
6dwnD-3da1A:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbi SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY


(Escherichia
coli)
PF13377
(Peripla_BP_3)
5 ILE A 184
SER A 273
GLY A 180
ALA A 179
ILE A 275
None
1.10A 6dwnD-3dbiA:
undetectable
6dwnD-3dbiA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djd FRUCTOSYL AMINE:
OXYGEN
OXIDOREDUCTASE


(Aspergillus
fumigatus)
PF01266
(DAO)
5 ILE A 435
GLY A  48
ALA A  47
PHE A 367
LEU A 238
None
FAD  A 500 (-3.9A)
FAD  A 500 (-3.2A)
None
None
1.11A 6dwnD-3djdA:
undetectable
6dwnD-3djdA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B


(Homo sapiens)
PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
5 ILE A1124
PHE A1179
GLY A1157
ILE A1229
LEU A1184
None
1.08A 6dwnD-3eh1A:
undetectable
6dwnD-3eh1A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B


(Homo sapiens)
PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
5 ILE A1169
PHE A1179
GLY A1157
ASP A1176
ILE A1192
None
0.91A 6dwnD-3eh1A:
undetectable
6dwnD-3eh1A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3es5 PUTATIVE CAPSID
PROTEIN


(Penicillium
stoloniferum
virus F)
no annotation 5 ILE A  83
GLY A 379
ALA A 355
ILE A 160
LEU A  75
None
1.12A 6dwnD-3es5A:
undetectable
6dwnD-3es5A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE


(Oenococcus oeni)
PF12697
(Abhydrolase_6)
5 ILE A 210
PHE A 208
PHE A 261
ALA A 100
ILE A 121
None
1.10A 6dwnD-3fsgA:
undetectable
6dwnD-3fsgA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5t TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY


(Corynebacterium
glutamicum)
PF00356
(LacI)
PF13377
(Peripla_BP_3)
5 ILE A 192
SER A 299
GLY A 188
ALA A 187
ASP A 186
None
1.05A 6dwnD-3h5tA:
undetectable
6dwnD-3h5tA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbn UDP-SUGAR HYDROLASE

(Campylobacter
jejuni)
no annotation 5 SER A 173
ASP A 168
GLY A 166
PHE A  15
ILE A 188
None
None
UDP  A 301 (-3.5A)
None
None
1.08A 6dwnD-3hbnA:
undetectable
6dwnD-3hbnA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn0 NITRATE TRANSPORT
PROTEIN


(Parabacteroides
distasonis)
no annotation 5 SER A 255
GLY A 249
ALA A 250
ILE A  37
LEU A 240
None
1.00A 6dwnD-3hn0A:
undetectable
6dwnD-3hn0A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr7 UNCHARACTERIZED EGV
FAMILY PROTEIN
COG1307


([Ruminococcus]
gnavus)
PF02645
(DegV)
5 PHE A  32
ASP A  59
ALA A  46
ASP A  27
ILE A  49
None
1.10A 6dwnD-3jr7A:
undetectable
6dwnD-3jr7A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ka7 OXIDOREDUCTASE

(Methanosarcina
mazei)
PF01593
(Amino_oxidase)
5 ASN A 377
GLY A 411
ALA A 413
ILE A 198
LEU A  10
FAD  A 500 ( 4.7A)
None
None
None
None
1.12A 6dwnD-3ka7A:
undetectable
6dwnD-3ka7A:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyj PUTATIVE HISTIDINE
PROTEIN KINASE


(Rhodobacter
sphaeroides)
PF01627
(Hpt)
5 ILE A  90
GLY A  83
ALA A  82
ASP A  81
ILE A 131
None
1.04A 6dwnD-3kyjA:
undetectable
6dwnD-3kyjA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Kosmotoga
olearia)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ILE A 129
GLY A 368
ALA A 369
PHE A 371
ILE A 285
None
1.06A 6dwnD-3mwcA:
undetectable
6dwnD-3mwcA:
11.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pm0 CYTOCHROME P450 1B1

(Homo sapiens)
PF00067
(p450)
6 ASN A 228
PHE A 231
PHE A 268
ASP A 326
GLY A 329
LEU A 509
BHF  A 800 (-4.2A)
BHF  A 800 (-3.4A)
BHF  A 800 ( 3.8A)
BHF  A 800 (-3.4A)
BHF  A 800 ( 4.0A)
BHF  A 800 (-4.7A)
1.26A 6dwnD-3pm0A:
46.9
6dwnD-3pm0A:
58.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pm0 CYTOCHROME P450 1B1

(Homo sapiens)
PF00067
(p450)
8 PHE A 231
PHE A 268
ASP A 326
GLY A 329
ALA A 330
ASP A 333
ILE A 399
LEU A 509
BHF  A 800 (-3.4A)
BHF  A 800 ( 3.8A)
BHF  A 800 (-3.4A)
BHF  A 800 ( 4.0A)
HEM  A 900 ( 3.4A)
BHF  A 800 ( 4.1A)
HEM  A 900 (-4.0A)
BHF  A 800 (-4.7A)
0.71A 6dwnD-3pm0A:
46.9
6dwnD-3pm0A:
58.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rju BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE


(Yersinia pestis)
PF00144
(Beta-lactamase)
5 SER A 228
ASP A 232
GLY A 189
ILE A 226
LEU A 180
None
1.07A 6dwnD-3rjuA:
undetectable
6dwnD-3rjuA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t33 G PROTEIN COUPLED
RECEPTOR


(Arabidopsis
thaliana)
PF05147
(LANC_like)
5 ILE A 327
PHE A 405
GLY A 288
ALA A 227
ILE A 122
None
1.09A 6dwnD-3t33A:
undetectable
6dwnD-3t33A:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v11 TRANSLATION
INITIATION FACTOR 2
SUBUNIT ALPHA


(Sulfolobus
solfataricus)
PF00575
(S1)
PF07541
(EIF_2_alpha)
5 ILE B 217
ASN B 244
GLY B 181
ILE B 200
LEU B 250
None
1.09A 6dwnD-3v11B:
undetectable
6dwnD-3v11B:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsy SORTILIN-RELATED
RECEPTOR


(Homo sapiens)
PF15901
(Sortilin_C)
PF15902
(Sortilin-Vps10)
5 ASN A 674
ASP A 357
GLY A 733
ASP A 734
LEU A 644
NAG  A 805 (-1.7A)
None
None
None
None
1.06A 6dwnD-3wsyA:
undetectable
6dwnD-3wsyA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wuf ENDO-1,4-BETA-XYLANA
SE A


(Streptomyces
sp.)
PF00331
(Glyco_hydro_10)
5 ILE A 308
GLY A 293
ALA A 294
ASP A 291
LEU A 244
None
1.09A 6dwnD-3wufA:
undetectable
6dwnD-3wufA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP


(Thermotoga
maritima)
PF03030
(H_PPase)
5 ILE A 186
GLY A 239
ALA A 238
ILE A  92
LEU A  50
None
1.10A 6dwnD-4av6A:
2.0
6dwnD-4av6A:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4duu PLASMINOGEN

(Homo sapiens)
PF00024
(PAN_1)
PF00051
(Kringle)
PF00089
(Trypsin)
5 SER A 203
PHE A 227
GLY A 199
ALA A 675
ASP A 676
None
0.97A 6dwnD-4duuA:
undetectable
6dwnD-4duuA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euf PUTATIVE REDUCTASE
CA_C0462


(Clostridium
acetobutylicum)
PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b)
5 ILE A 309
PHE A 313
GLY A  63
ILE A  45
LEU A 134
None
1.07A 6dwnD-4eufA:
undetectable
6dwnD-4eufA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe9 OUTER MEMBRANE
PROTEIN SUSF


(Bacteroides
thetaiotaomicron)
PF16411
(SusF_SusE)
PF17142
(DUF5115)
5 ILE A 484
PHE A 421
GLY A 425
ILE A 429
LEU A 387
None
0.99A 6dwnD-4fe9A:
undetectable
6dwnD-4fe9A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ff5 GLYCOSYL HYDROLASE
25


(Streptococcus
pneumoniae)
PF01183
(Glyco_hydro_25)
6 ILE A 214
ASN A 224
GLY A  54
PHE A 240
ILE A  43
LEU A  34
None
1.23A 6dwnD-4ff5A:
undetectable
6dwnD-4ff5A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fj6 GLYCOSIDE HYDROLASE
FAMILY 33, CANDIDATE
SIALIDASE


(Parabacteroides
distasonis)
PF13859
(BNR_3)
PF14873
(BNR_assoc_N)
5 ILE A  70
GLY A  62
ALA A 158
ILE A  32
LEU A  41
None
1.06A 6dwnD-4fj6A:
undetectable
6dwnD-4fj6A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fk1 PUTATIVE THIOREDOXIN
REDUCTASE


(Bacillus
anthracis)
PF07992
(Pyr_redox_2)
5 ILE C 227
PHE C 131
GLY C 224
ILE C 199
LEU C 202
None
0.99A 6dwnD-4fk1C:
undetectable
6dwnD-4fk1C:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN


(Bacteroides
ovatus)
PF13306
(LRR_5)
5 ILE A 354
PHE A 382
PHE A 410
ILE A 345
LEU A 365
None
0.87A 6dwnD-4fs7A:
undetectable
6dwnD-4fs7A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4


(Homo sapiens)
PF01189
(Methyltr_RsmB-F)
5 SER A 162
PHE A  98
ASP A 159
GLY A  74
PHE A 142
None
1.04A 6dwnD-4fzvA:
undetectable
6dwnD-4fzvA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gud IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISH


(Vibrio cholerae)
PF00117
(GATase)
5 PHE A 184
GLY A 193
ALA A 194
ILE A  22
LEU A 201
None
1.05A 6dwnD-4gudA:
undetectable
6dwnD-4gudA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxt DE NOVO PROTEIN
OR329


(synthetic
construct)
PF00514
(Arm)
5 ILE A  71
GLY A  44
ALA A  43
ASP A  42
ILE A  29
None
1.07A 6dwnD-4hxtA:
undetectable
6dwnD-4hxtA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxt DE NOVO PROTEIN
OR329


(synthetic
construct)
PF00514
(Arm)
5 ILE A 155
GLY A 128
ALA A 127
ASP A 126
ILE A 113
None
1.05A 6dwnD-4hxtA:
undetectable
6dwnD-4hxtA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxt DE NOVO PROTEIN
OR329


(synthetic
construct)
PF00514
(Arm)
5 ILE A 197
GLY A 170
ALA A 169
ASP A 168
ILE A 155
None
1.06A 6dwnD-4hxtA:
undetectable
6dwnD-4hxtA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxt DE NOVO PROTEIN
OR329


(synthetic
construct)
PF00514
(Arm)
5 ILE A 239
GLY A 212
ALA A 211
ASP A 210
ILE A 197
None
0.99A 6dwnD-4hxtA:
undetectable
6dwnD-4hxtA:
14.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8v CYTOCHROME P450 1A1

(Homo sapiens)
PF00067
(p450)
11 ILE A 115
SER A 122
ASN A 222
PHE A 224
PHE A 258
ASP A 313
GLY A 316
ALA A 317
PHE A 319
ILE A 386
LEU A 496
BHF  A 602 (-4.7A)
HEM  A 601 (-3.4A)
BHF  A 602 ( 3.8A)
BHF  A 602 (-3.3A)
BHF  A 602 ( 3.9A)
BHF  A 602 (-3.7A)
BHF  A 602 (-3.5A)
BHF  A 602 ( 3.4A)
BHF  A 602 ( 4.7A)
HEM  A 601 (-3.6A)
None
0.78A 6dwnD-4i8vA:
59.1
6dwnD-4i8vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8v CYTOCHROME P450 1A1

(Homo sapiens)
PF00067
(p450)
11 ILE A 115
SER A 122
PHE A 224
PHE A 258
ASP A 313
GLY A 316
ALA A 317
PHE A 319
ASP A 320
ILE A 386
LEU A 496
BHF  A 602 (-4.7A)
HEM  A 601 (-3.4A)
BHF  A 602 (-3.3A)
BHF  A 602 ( 3.9A)
BHF  A 602 (-3.7A)
BHF  A 602 (-3.5A)
BHF  A 602 ( 3.4A)
BHF  A 602 ( 4.7A)
BHF  A 602 (-3.7A)
HEM  A 601 (-3.6A)
None
0.53A 6dwnD-4i8vA:
59.1
6dwnD-4i8vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8v CYTOCHROME P450 1A1

(Homo sapiens)
PF00067
(p450)
6 SER A 120
PHE A 224
ASP A 313
GLY A 316
PHE A 319
ASP A 320
BHF  A 602 ( 4.5A)
BHF  A 602 (-3.3A)
BHF  A 602 (-3.7A)
BHF  A 602 (-3.5A)
BHF  A 602 ( 4.7A)
BHF  A 602 (-3.7A)
1.42A 6dwnD-4i8vA:
59.1
6dwnD-4i8vA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Rickettsia
rickettsii)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 ILE A 184
GLY A 276
ALA A 301
ASP A 304
ILE A 423
None
1.09A 6dwnD-4jgaA:
undetectable
6dwnD-4jgaA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4klk PHAGE-RELATED
PROTEIN DUF2815


(Enterococcus
faecalis)
PF10991
(DUF2815)
5 ILE A 138
PHE A 140
ALA A  51
ILE A  41
LEU A  80
None
1.08A 6dwnD-4klkA:
undetectable
6dwnD-4klkA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt1 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4


(Homo sapiens)
PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8)
5 ILE A 244
GLY A 266
ALA A 291
ILE A 277
LEU A 295
None
1.09A 6dwnD-4kt1A:
undetectable
6dwnD-4kt1A:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1n CONSERVED
LIPOPROTEIN,
PUTATIVE


(Clostridium
novyi)
PF15525
(DUF4652)
5 ILE A 115
GLY A 126
ALA A 172
ILE A 169
LEU A 145
None
1.10A 6dwnD-4l1nA:
undetectable
6dwnD-4l1nA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nk6 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE


(Pseudomonas
syringae group
genomosp. 3)
PF13229
(Beta_helix)
5 ILE A 281
ASN A 311
PHE A 286
GLY A 258
ILE A 203
None
1.11A 6dwnD-4nk6A:
undetectable
6dwnD-4nk6A:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN


(Streptomyces
pristinaespiralis)
no annotation 5 ILE A 219
SER A  12
PHE A 297
GLY A 300
PHE A  55
None
1.08A 6dwnD-4okmA:
undetectable
6dwnD-4okmA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv1 ENGINEERED PROTEIN
OR497


(synthetic
construct)
PF00514
(Arm)
5 ILE A  71
GLY A  44
ALA A  43
ASP A  42
ILE A  29
None
1.06A 6dwnD-4rv1A:
undetectable
6dwnD-4rv1A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv1 ENGINEERED PROTEIN
OR497


(synthetic
construct)
PF00514
(Arm)
5 ILE A 281
GLY A 254
ALA A 253
ASP A 252
ILE A 239
None
1.10A 6dwnD-4rv1A:
undetectable
6dwnD-4rv1A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv1 ENGINEERED PROTEIN
OR497


(synthetic
construct)
PF00514
(Arm)
5 ILE A 407
GLY A 380
ALA A 379
ASP A 378
ILE A 365
None
1.07A 6dwnD-4rv1A:
undetectable
6dwnD-4rv1A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv7 DIADENYLATE CYCLASE

(Listeria
monocytogenes)
PF02457
(DisA_N)
5 ILE A  32
PHE A  63
GLY A  72
ALA A  85
ILE A  81
None
None
ATP  A1001 (-3.3A)
None
None
1.10A 6dwnD-4rv7A:
undetectable
6dwnD-4rv7A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmc OLD YELLOW ENZYME

(Kluyveromyces
marxianus)
PF00724
(Oxidored_FMN)
5 ILE A 166
ASN A 207
PHE A 201
GLY A 160
LEU A 197
None
1.11A 6dwnD-4tmcA:
undetectable
6dwnD-4tmcA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wia PUTATIVE
FLAGELLA-RELATED
PROTEIN H


(Methanocaldococcus
jannaschii)
PF06745
(ATPase)
6 SER A  28
ASN A  54
PHE A  51
GLY A  23
ILE A  30
LEU A  47
None
1.39A 6dwnD-4wiaA:
undetectable
6dwnD-4wiaA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wp3 MA1120

(Mycobacterium
avium)
PF00211
(Guanylate_cyc)
5 ILE A 194
PHE A 196
ALA A 187
ASP A 186
ILE A 146
None
1.09A 6dwnD-4wp3A:
undetectable
6dwnD-4wp3A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wp8 MA1120

(Mycobacterium
avium)
PF00211
(Guanylate_cyc)
5 ILE A 194
PHE A 196
ALA A 187
ASP A 186
ILE A 146
None
1.06A 6dwnD-4wp8A:
undetectable
6dwnD-4wp8A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0a SHIKIMATE KINASE

(Acinetobacter
baumannii)
PF01202
(SKI)
5 ILE A  61
SER A  49
PHE A  73
GLY A  97
ALA A  98
SKM  A 201 ( 4.0A)
None
SKM  A 201 (-3.5A)
SKM  A 201 (-3.2A)
None
1.05A 6dwnD-4y0aA:
undetectable
6dwnD-4y0aA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE


(Bacillus cereus)
PF05547
(Peptidase_M6)
5 ILE A 181
PHE A 193
GLY A 372
ALA A 373
PHE A 377
None
1.11A 6dwnD-4yu5A:
undetectable
6dwnD-4yu5A:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z11 AURONE SYNTHASE

(Coreopsis
grandiflora)
PF00264
(Tyrosinase)
PF12142
(PPO1_DWL)
PF12143
(PPO1_KFDV)
5 ILE A 418
PHE A 428
GLY A 452
ILE A 507
LEU A 493
None
1.10A 6dwnD-4z11A:
undetectable
6dwnD-4z11A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE


(Streptomyces
platensis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 ILE A 859
PHE A 881
ASP A 884
ILE A 979
LEU A 846
None
1.09A 6dwnD-4zdnA:
undetectable
6dwnD-4zdnA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR


(Sphaerobacter
thermophilus)
PF13458
(Peripla_BP_6)
5 ILE A  81
GLY A 112
ALA A 111
ASP A 109
ILE A 374
None
1.10A 6dwnD-4zpjA:
undetectable
6dwnD-4zpjA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ao8 SOLUBLE LYTIC
TRANGLYCOSILASE B3


(Pseudomonas
aeruginosa)
PF01471
(PG_binding_1)
PF13406
(SLT_2)
5 ILE A 184
ASN A 156
GLY A 201
ALA A 202
ILE A 228
None
None
None
NAG  A 999 ( 4.1A)
None
0.93A 6dwnD-5ao8A:
undetectable
6dwnD-5ao8A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awp ISOMALTODEXTRANASE

(Arthrobacter
globiformis)
no annotation 5 ASN A 214
PHE A 156
ASP A 197
ILE A  80
LEU A 165
None
GLC  A 702 ( 4.9A)
BGC  A 701 (-3.0A)
GLC  A 702 (-4.1A)
None
0.92A 6dwnD-5awpA:
undetectable
6dwnD-5awpA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e38 URACIL
PHOSPHORIBOSYLTRANSF
ERASE


(Mycobacterium
tuberculosis)
PF14681
(UPRTase)
5 ASN A  25
PHE A  28
GLY A 200
ALA A  78
LEU A  32
None
1.04A 6dwnD-5e38A:
undetectable
6dwnD-5e38A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5f TAU CLASS
GLUTATHIONE
S-TRANSFERASE


(Mangifera
indica)
PF00043
(GST_C)
PF02798
(GST_N)
5 ILE A 137
PHE A 163
ALA A 194
PHE A 197
LEU A 170
None
1.03A 6dwnD-5g5fA:
undetectable
6dwnD-5g5fA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt5 PECTATE LYASE

(Paenibacillus
sp. 0602)
no annotation 5 ILE A 188
PHE A 193
GLY A 430
ALA A 429
ILE A 290
None
1.11A 6dwnD-5gt5A:
undetectable
6dwnD-5gt5A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmp UNCONVENTIONAL
MYOSIN-VC


(Homo sapiens)
PF00063
(Myosin_head)
5 ILE A 158
GLY A 432
PHE A 430
ILE A 436
LEU A 635
None
1.03A 6dwnD-5hmpA:
undetectable
6dwnD-5hmpA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE


(Shewanella
oneidensis)
PF01041
(DegT_DnrJ_EryC1)
5 ILE A 162
PHE A 182
GLY A  61
ALA A  64
ILE A 197
None
None
PDG  A 501 (-3.4A)
None
None
1.02A 6dwnD-5k8bA:
undetectable
6dwnD-5k8bA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1t MUCR
PHOSPHODIESTERASE


(Pseudomonas
aeruginosa)
PF00563
(EAL)
5 ILE A 612
ASN A 664
GLY A 637
ALA A 635
LEU A 661
None
1.11A 6dwnD-5m1tA:
undetectable
6dwnD-5m1tA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7s FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE


(Acinetobacter
baumannii)
PF01116
(F_bP_aldolase)
5 ILE A 192
PHE A 181
GLY A 141
ASP A 105
LEU A 146
None
1.07A 6dwnD-5u7sA:
undetectable
6dwnD-5u7sA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w75 ELONGATION FACTOR TU

(Thermotoga
neapolitana)
no annotation 5 ILE A  93
ALA A 376
PHE A 331
ILE A  61
LEU A 312
None
1.11A 6dwnD-5w75A:
undetectable
6dwnD-5w75A:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5way TRANSCRIPTIONAL
ACTIVATOR


(Streptococcus
pneumoniae)
PF05043
(Mga)
PF08270
(PRD_Mga)
PF08280
(HTH_Mga)
5 ILE A 143
SER A 137
PHE A 213
GLY A 100
ILE A 121
None
1.05A 6dwnD-5wayA:
undetectable
6dwnD-5wayA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyp DNA POLYMERASE III
SUBUNIT BETA


(Caulobacter
vibrioides)
no annotation 5 ILE A 323
ASN A 258
PHE A 346
ILE A 296
LEU A 262
None
0.94A 6dwnD-5wypA:
undetectable
6dwnD-5wypA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zya SPLICING FACTOR 3B
SUBUNIT 1


(Homo sapiens)
no annotation 5 ILE C 872
GLY C 880
ALA C 881
ASP C 883
LEU C 888
None
1.05A 6dwnD-5zyaC:
undetectable
6dwnD-5zyaC:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1


(Bos taurus)
no annotation 5 ILE A 726
ASP A 757
ASP A 749
ILE A 761
LEU A 768
None
1.04A 6dwnD-6bhuA:
undetectable
6dwnD-6bhuA:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cuq MACROPHAGE MIGRATION
INHIBITORY
FACTOR-LIKE PROTEIN


(Entamoeba
histolytica)
no annotation 5 ILE A  94
GLY A  88
ALA A  87
ILE A   6
LEU A  82
None
1.10A 6dwnD-6cuqA:
undetectable
6dwnD-6cuqA:
19.32