SIMILAR PATTERNS OF AMINO ACIDS FOR 6DWN_C_AQ4C602_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTM, FLAVOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 ASN C  55
LEU C  31
ASP C 115
GLY C 110
ILE C 170
 None
None
FAD  C1922 (-2.9A)
FAD  C1922 (-3.7A)
None
 0.99A 6dwnC-1ffvC:
0.0		 6dwnC-1ffvC:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6u INTERNALIN H

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		5 ILE A 154
LEU A 173
ASN A 174
ILE A 138
LEU A 147
 None
 1.05A 6dwnC-1h6uA:
undetectable		 6dwnC-1h6uA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hv8 PUTATIVE
ATP-DEPENDENT RNA
HELICASE MJ0669

(Methanocaldococcus
jannaschii) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 ILE A  37
LEU A  97
PHE A  26
GLY A  56
ILE A  47
 None
None
None
SO4  A 803 (-3.6A)
None
 1.09A 6dwnC-1hv8A:
0.0		 6dwnC-1hv8A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jyo SICP
PROTEIN TYROSINE
PHOSPHATASE SPTP

(Salmonella
enterica;
Salmonella
enterica) 		PF05932
(CesT)
PF09119
(SicP-binding) 		6 ILE E 134
SER E 136
LEU A  30
GLY E 129
ILE A  85
LEU A  92
 None
 1.34A 6dwnC-1jyoE:
undetectable		 6dwnC-1jyoE:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nst HEPARAN SULFATE
N-DEACETYLASE/N-SULF
OTRANSFERASE

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		5 LEU A 859
ASN A 856
ASP A 708
ILE A 734
LEU A 752
 None
 0.99A 6dwnC-1nstA:
0.0		 6dwnC-1nstA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odf HYPOTHETICAL 33.3
KDA PROTEIN IN
ADE3-SER2 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		no annotation 5 ILE A 202
PHE A  35
GLY A 164
PHE A 259
LEU A 158
 None
 1.10A 6dwnC-1odfA:
0.0		 6dwnC-1odfA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06969
(HemN_C) 		5 ILE A 388
SER A 376
PHE A 396
LEU A 395
GLY A 422
 None
 1.11A 6dwnC-1oltA:
0.0		 6dwnC-1oltA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9w GENERAL SECRETION
PATHWAY PROTEIN E

(Vibrio cholerae) 		PF00437
(T2SSE) 		5 ILE A 380
LEU A 454
GLY A 365
ILE A 335
LEU A 261
 None
 1.07A 6dwnC-1p9wA:
undetectable		 6dwnC-1p9wA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 ASN A 169
LEU A 172
GLY A 248
ILE A 533
LEU A 220
 None
 1.08A 6dwnC-1ps9A:
undetectable		 6dwnC-1ps9A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ueb ELONGATION FACTOR P

(Thermus
thermophilus) 		PF01132
(EFP)
PF08207
(EFP_N)
PF09285
(Elong-fact-P_C) 		5 ILE A 120
LEU A  70
PHE A  91
GLY A 117
ILE A  63
 None
 1.05A 6dwnC-1uebA:
undetectable		 6dwnC-1uebA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 ILE A 113
SER A 186
LEU A  57
ILE A 190
LEU A 131
 None
 1.11A 6dwnC-1v0bA:
undetectable		 6dwnC-1v0bA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7s RNA-DEPENDENT RNA
POLYMERASE

(Foot-and-mouth
disease virus) 		PF00680
(RdRP_1) 		5 ILE A 309
SER A 213
PHE A 199
ILE A 211
LEU A  89
 None
 1.04A 6dwnC-2d7sA:
undetectable		 6dwnC-2d7sA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)

(Homo sapiens) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		5 ILE A 235
ASP A 257
GLY A 258
ILE A 242
LEU A 254
 None
 1.05A 6dwnC-2hgsA:
undetectable		 6dwnC-2hgsA:
10.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens) 		PF00067
(p450) 		7 ILE A 117
PHE A 226
ASN A 257
ASP A 313
GLY A 316
ILE A 386
LEU A 497
 None
BHF  A 800 (-3.6A)
None
BHF  A 800 (-3.9A)
BHF  A 800 (-3.8A)
HEM  A 900 (-4.0A)
BHF  A 800 (-4.4A)
 0.64A 6dwnC-2hi4A:
55.3		 6dwnC-2hi4A:
81.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens) 		PF00067
(p450) 		5 ILE A 117
PHE A 226
ASN A 257
PHE A 260
LEU A 497
 None
BHF  A 800 (-3.6A)
None
BHF  A 800 (-3.6A)
BHF  A 800 (-4.4A)
 0.89A 6dwnC-2hi4A:
55.3		 6dwnC-2hi4A:
81.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icg LIN2918 PROTEIN

(Listeria
innocua) 		PF14568
(SUKH_6) 		5 ILE A 110
LEU A 147
PHE A  49
GLY A  65
ILE A  92
 None
 1.10A 6dwnC-2icgA:
undetectable		 6dwnC-2icgA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oej 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE

(Geobacillus
kaustophilus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 PHE A 331
LEU A 320
ASP A 128
GLY A 126
LEU A 141
 None
 1.06A 6dwnC-2oejA:
undetectable		 6dwnC-2oejA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Staphylococcus
haemolyticus) 		PF01409
(tRNA-synt_2d) 		5 ILE A 130
LEU A 122
PHE A 123
GLY A 217
PHE A 312
 None
 1.01A 6dwnC-2rhqA:
undetectable		 6dwnC-2rhqA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		5 ILE A 148
GLY A 453
PHE A 451
ILE A 457
LEU A 654
 None
None
None
EDO  A1793 ( 3.9A)
None
 1.09A 6dwnC-2v26A:
undetectable		 6dwnC-2v26A:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwk DNA POLYMERASE

(Thermococcus
gorgonarius) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		6 PHE A 405
LEU A 564
ASN A 568
PHE A 544
ILE A 412
LEU A 408
 None
 1.47A 6dwnC-2vwkA:
0.0		 6dwnC-2vwkA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wab ENDOGLUCANASE E

(Ruminiclostridium
thermocellum) 		PF00657
(Lipase_GDSL) 		5 ILE A 178
ASN A 183
GLY A 222
ILE A 128
LEU A 243
 GOL  A1342 (-4.4A)
GOL  A1342 (-3.4A)
None
None
None
 1.07A 6dwnC-2wabA:
undetectable		 6dwnC-2wabA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK) 		PF00202
(Aminotran_3) 		6 LEU A 352
ASN A 351
PHE A 348
ASP A 423
GLY A 425
PHE A  85
 None
 1.27A 6dwnC-2ykyA:
0.0		 6dwnC-2ykyA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		5 ILE A  65
LEU A  57
GLY A 107
ILE A  98
LEU A  46
 None
 1.03A 6dwnC-2yr0A:
undetectable		 6dwnC-2yr0A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3d PUTATIVE MORPHINE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		5 LEU A 196
ASP A  49
GLY A  21
PHE A  20
ILE A 165
 CA  A 281 (-4.2A)
None
None
None
None
 1.11A 6dwnC-3b3dA:
undetectable		 6dwnC-3b3dA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chx PMOB
PMOA

(Methylosinus
trichosporium;
Methylosinus
trichosporium) 		PF04744
(Monooxygenase_B)
PF02461
(AMO) 		5 LEU B 123
PHE B 119
GLY A 102
ILE A 166
LEU A 105
 None
 1.00A 6dwnC-3chxB:
undetectable		 6dwnC-3chxB:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ILE A 405
ASN A 103
LEU A 524
ILE A 380
LEU A 500
 None
None
None
None
CU  A 602 ( 4.9A)
 0.98A 6dwnC-3dkhA:
undetectable		 6dwnC-3dkhA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2j ATP SYNTHASE SUBUNIT
S, MITOCHONDRIAL

(Bos taurus) 		no annotation 5 ILE A  72
PHE A  77
ASN A  10
ILE A  89
LEU A 105
 None
 1.16A 6dwnC-3e2jA:
undetectable		 6dwnC-3e2jA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e38 TWO-DOMAIN PROTEIN
CONTAINING PREDICTED
PHP-LIKE
METAL-DEPENDENT
PHOSPHOESTERASE

(Bacteroides
vulgatus) 		PF16392
(DUF5001) 		5 PHE A 154
ASN A 156
ASP A  42
GLY A 211
ILE A 109
 None
 1.10A 6dwnC-3e38A:
undetectable		 6dwnC-3e38A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e73 LANC-LIKE PROTEIN 1

(Homo sapiens) 		PF05147
(LANC_like) 		5 ILE A 182
LEU A 140
ASN A 141
GLY A 157
LEU A 163
 None
 1.06A 6dwnC-3e73A:
undetectable		 6dwnC-3e73A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 ILE A1124
PHE A1179
GLY A1157
ILE A1229
LEU A1184
 None
 1.00A 6dwnC-3eh1A:
undetectable		 6dwnC-3eh1A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk4 RUBISCO-LIKE PROTEIN

(Bacillus cereus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 PHE A 332
LEU A 321
ASP A 129
GLY A 127
LEU A 142
 None
 1.07A 6dwnC-3fk4A:
undetectable		 6dwnC-3fk4A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn1 NEDD8-CONJUGATING
ENZYME UBE2F

(Homo sapiens) 		PF00179
(UQ_con) 		5 ILE B 104
PHE B 172
PHE B 153
ILE B 115
LEU B 146
 None
 1.13A 6dwnC-3fn1B:
undetectable		 6dwnC-3fn1B:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsc QDTC

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00132
(Hexapep) 		5 ILE A 121
SER A 143
ASN A 136
ILE A 145
LEU A 151
 None
 1.11A 6dwnC-3fscA:
undetectable		 6dwnC-3fscA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1p PROTEIN PHNP

(Escherichia
coli) 		PF12706
(Lactamase_B_2) 		5 SER A  41
PHE A 244
GLY A 246
ILE A  53
LEU A   5
 None
 1.15A 6dwnC-3g1pA:
undetectable		 6dwnC-3g1pA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf6 UNCHARACTERIZED
BACTERIAL
LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12956
(DUF3845) 		5 ILE A 229
ASN A  56
GLY A  97
PHE A  95
LEU A 136
 None
 1.13A 6dwnC-3gf6A:
undetectable		 6dwnC-3gf6A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 ILE A 289
SER A 314
GLY A 330
ILE A 357
LEU A 333
 None
 1.06A 6dwnC-3h11A:
undetectable		 6dwnC-3h11A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5

(Homo sapiens) 		PF00149
(Metallophos)
PF08321
(PPP5) 		5 SER A 403
ASN A 269
LEU A 300
ASP A 383
GLY A 354
 None
 1.15A 6dwnC-3h68A:
undetectable		 6dwnC-3h68A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbn UDP-SUGAR HYDROLASE

(Campylobacter
jejuni) 		no annotation 5 SER A 173
ASP A 168
GLY A 166
PHE A  15
ILE A 188
 None
None
UDP  A 301 (-3.5A)
None
None
 1.07A 6dwnC-3hbnA:
undetectable		 6dwnC-3hbnA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htx HEN1

(Arabidopsis
thaliana) 		PF13847
(Methyltransf_31) 		5 ILE A 351
PHE A 267
GLY A 317
ILE A 224
LEU A 278
 None
 1.14A 6dwnC-3htxA:
undetectable		 6dwnC-3htxA:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikb UNCHARACTERIZED
CONSERVED PROTEIN

(Streptococcus
mutans) 		PF03167
(UDG) 		5 ILE A  11
PHE A 104
ASN A  17
PHE A  20
ILE A 112
 None
 1.04A 6dwnC-3ikbA:
undetectable		 6dwnC-3ikbA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3imk PUTATIVE MOLYBDENUM
CARRIER PROTEIN

(Syntrophus
aciditrophicus) 		PF12694
(MoCo_carrier) 		5 SER A  12
ASP A  19
GLY A  17
ILE A  10
LEU A 152
 None
GOL  A 158 (-2.9A)
MES  A 160 (-3.5A)
None
None
 0.96A 6dwnC-3imkA:
undetectable		 6dwnC-3imkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lae UPF0053 PROTEIN
HI0107

(Haemophilus
influenzae) 		PF03471
(CorC_HlyC) 		5 ILE A  62
LEU A  58
GLY A  12
ILE A  46
LEU A  40
 None
None
EDO  A  80 ( 4.8A)
None
None
 1.05A 6dwnC-3laeA:
undetectable		 6dwnC-3laeA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnb N-ACETYLTRANSFERASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00797
(Acetyltransf_2) 		5 ILE A 111
LEU A  72
ASN A  73
PHE A   9
LEU A  25
 None
 1.01A 6dwnC-3lnbA:
undetectable		 6dwnC-3lnbA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mes CHOLINE KINASE

(Cryptosporidium
parvum) 		PF01633
(Choline_kinase) 		5 LEU A 338
ASP A 297
GLY A 295
ILE A 291
LEU A 262
 None
 1.13A 6dwnC-3mesA:
undetectable		 6dwnC-3mesA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwe ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF16114
(Citrate_bind) 		5 ILE A 357
LEU A 388
GLY A 341
ILE A 323
LEU A 338
 None
 1.13A 6dwnC-3mweA:
undetectable		 6dwnC-3mweA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		5 ILE A 213
LEU A 218
PHE A 309
ILE A 167
LEU A 165
 None
 1.14A 6dwnC-3ohtA:
undetectable		 6dwnC-3ohtA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oid ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH]

(Bacillus
subtilis) 		PF13561
(adh_short_C2) 		5 ILE A 145
SER A 247
LEU A 161
GLY A 184
LEU A 148
 None
None
None
NDP  A 501 (-3.9A)
None
 1.15A 6dwnC-3oidA:
undetectable		 6dwnC-3oidA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pao ADENOSINE DEAMINASE

(Pseudomonas
aeruginosa) 		PF00962
(A_deaminase) 		5 PHE A 162
LEU A 156
PHE A 139
ILE A 118
LEU A 135
 None
 1.11A 6dwnC-3paoA:
undetectable		 6dwnC-3paoA:
11.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pm0 CYTOCHROME P450 1B1

(Homo sapiens) 		PF00067
(p450) 		6 ASN A 228
PHE A 231
PHE A 268
ASP A 326
GLY A 329
LEU A 509
 BHF  A 800 (-4.2A)
BHF  A 800 (-3.4A)
BHF  A 800 ( 3.8A)
BHF  A 800 (-3.4A)
BHF  A 800 ( 4.0A)
BHF  A 800 (-4.7A)
 1.11A 6dwnC-3pm0A:
48.2		 6dwnC-3pm0A:
58.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pm0 CYTOCHROME P450 1B1

(Homo sapiens) 		PF00067
(p450) 		7 PHE A 231
ASN A 265
PHE A 268
ASP A 326
GLY A 329
ILE A 399
LEU A 509
 BHF  A 800 (-3.4A)
None
BHF  A 800 ( 3.8A)
BHF  A 800 (-3.4A)
BHF  A 800 ( 4.0A)
HEM  A 900 (-4.0A)
BHF  A 800 (-4.7A)
 0.65A 6dwnC-3pm0A:
48.2		 6dwnC-3pm0A:
58.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvm OLEI00960

(Oleispira
antarctica) 		PF00561
(Abhydrolase_1) 		5 ILE A 251
ASP A 262
GLY A 264
ILE A 128
LEU A 270
 None
 1.07A 6dwnC-3qvmA:
undetectable		 6dwnC-3qvmA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rju BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE

(Yersinia pestis) 		PF00144
(Beta-lactamase) 		5 SER A 228
ASP A 232
GLY A 189
ILE A 226
LEU A 180
 None
 1.11A 6dwnC-3rjuA:
undetectable		 6dwnC-3rjuA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shm CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		5 SER A 675
PHE A 283
GLY A 281
ILE A 319
LEU A 316
 None
 1.06A 6dwnC-3shmA:
undetectable		 6dwnC-3shmA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc8 LEUCINE
AMINOPEPTIDASE

(Parabacteroides
distasonis) 		PF04389
(Peptidase_M28) 		5 LEU A 156
ASP A 146
GLY A 148
ILE A 286
LEU A 218
 None
 1.15A 6dwnC-3tc8A:
undetectable		 6dwnC-3tc8A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u62 SHIKIMATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 ILE A  14
PHE A 225
LEU A 252
PHE A 244
ILE A   5
 SO4  A 500 (-4.0A)
None
None
None
None
 1.07A 6dwnC-3u62A:
undetectable		 6dwnC-3u62A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 ILE A 126
LEU A 149
GLY A 165
ILE A 112
LEU A 119
 None
None
NDP  A 610 (-3.4A)
1CY  A 609 (-4.4A)
None
 1.15A 6dwnC-3um6A:
undetectable		 6dwnC-3um6A:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uqz DNA PROCESSING
PROTEIN DPRA

(Streptococcus
pneumoniae) 		PF02481
(DNA_processg_A) 		5 SER A 140
LEU A 255
ASP A 147
GLY A 145
ILE A 138
 None
 1.14A 6dwnC-3uqzA:
undetectable		 6dwnC-3uqzA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v11 TRANSLATION
INITIATION FACTOR 2
SUBUNIT ALPHA

(Sulfolobus
solfataricus) 		PF00575
(S1)
PF07541
(EIF_2_alpha) 		5 ILE B 217
ASN B 244
GLY B 181
ILE B 200
LEU B 250
 None
 1.05A 6dwnC-3v11B:
undetectable		 6dwnC-3v11B:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avr PA4485

(Pseudomonas
aeruginosa) 		PF03330
(DPBB_1) 		5 ILE A  57
ASN A  58
GLY A  61
PHE A  63
ILE A  91
 None
 1.11A 6dwnC-4avrA:
undetectable		 6dwnC-4avrA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF16417
(CNOT1_TTP_bind)
PF16418
(CNOT1_HEAT)
PF16419
(CNOT1_HEAT_N) 		5 ILE A 472
LEU A 499
PHE A 495
PHE A 534
ILE A 448
 None
 1.13A 6dwnC-4b8bA:
undetectable		 6dwnC-4b8bA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 123
SER A 196
LEU A  67
ILE A 200
LEU A 141
 None
 1.11A 6dwnC-4bgqA:
undetectable		 6dwnC-4bgqA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		5 ASP B 259
GLY B 222
PHE B 156
ILE B 325
LEU B 306
 None
 1.14A 6dwnC-4cakB:
undetectable		 6dwnC-4cakB:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe9 OUTER MEMBRANE
PROTEIN SUSF

(Bacteroides
thetaiotaomicron) 		PF16411
(SusF_SusE)
PF17142
(DUF5115) 		5 ILE A 484
PHE A 421
GLY A 425
ILE A 429
LEU A 387
 None
 0.98A 6dwnC-4fe9A:
undetectable		 6dwnC-4fe9A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ff5 GLYCOSYL HYDROLASE
25

(Streptococcus
pneumoniae) 		PF01183
(Glyco_hydro_25) 		5 ILE A 214
GLY A  54
PHE A 240
ILE A  43
LEU A  34
 None
 1.08A 6dwnC-4ff5A:
0.4		 6dwnC-4ff5A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffc 4-AMINOBUTYRATE
AMINOTRANSFERASE
(GABT)

(Mycobacteroides
abscessus) 		PF00202
(Aminotran_3) 		5 ILE A 349
LEU A 342
GLY A 427
ILE A 435
LEU A  65
 None
 1.13A 6dwnC-4ffcA:
undetectable		 6dwnC-4ffcA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fho INTERNALIN C2

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		5 ILE A 154
LEU A 173
ASN A 174
ILE A 138
LEU A 147
 None
 1.03A 6dwnC-4fhoA:
undetectable		 6dwnC-4fhoA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594

(Pyrococcus
horikoshii) 		PF00326
(Peptidase_S9)
PF07676
(PD40) 		5 ILE B 541
SER B 581
ASN B 473
LEU B 538
GLY B 464
 None
 1.12A 6dwnC-4hxeB:
undetectable		 6dwnC-4hxeB:
7.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		7 ASN A 222
LEU A 254
ASN A 255
PHE A 258
ASP A 313
GLY A 316
PHE A 319
 BHF  A 602 ( 3.8A)
None
None
BHF  A 602 ( 3.9A)
BHF  A 602 (-3.7A)
BHF  A 602 (-3.5A)
BHF  A 602 ( 4.7A)
 0.95A 6dwnC-4i8vA:
60.5		 6dwnC-4i8vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		6 ILE A 115
ASN A 223
PHE A 224
ASN A 255
ILE A 386
LEU A 496
 BHF  A 602 (-4.7A)
None
BHF  A 602 (-3.3A)
None
HEM  A 601 (-3.6A)
None
 1.44A 6dwnC-4i8vA:
60.5		 6dwnC-4i8vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		11 ILE A 115
SER A 122
ASN A 222
PHE A 224
ASN A 255
PHE A 258
ASP A 313
GLY A 316
PHE A 319
ILE A 386
LEU A 496
 BHF  A 602 (-4.7A)
HEM  A 601 (-3.4A)
BHF  A 602 ( 3.8A)
BHF  A 602 (-3.3A)
None
BHF  A 602 ( 3.9A)
BHF  A 602 (-3.7A)
BHF  A 602 (-3.5A)
BHF  A 602 ( 4.7A)
HEM  A 601 (-3.6A)
None
 0.63A 6dwnC-4i8vA:
60.5		 6dwnC-4i8vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		6 SER A 120
ASN A 222
PHE A 224
ASP A 313
GLY A 316
PHE A 319
 BHF  A 602 ( 4.5A)
BHF  A 602 ( 3.8A)
BHF  A 602 (-3.3A)
BHF  A 602 (-3.7A)
BHF  A 602 (-3.5A)
BHF  A 602 ( 4.7A)
 1.44A 6dwnC-4i8vA:
60.5		 6dwnC-4i8vA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt1 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 425
ASN A 423
ASP A 395
PHE A 409
LEU A 358
 None
 1.08A 6dwnC-4kt1A:
undetectable		 6dwnC-4kt1A:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mad BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF01301
(Glyco_hydro_35) 		5 LEU A 108
PHE A 104
GLY A  92
ILE A  73
LEU A 134
 None
 1.15A 6dwnC-4madA:
undetectable		 6dwnC-4madA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1j CARBONIC ANHYDRASE

(Sordaria
macrospora) 		PF00484
(Pro_CA) 		5 ASN A 155
LEU A 127
GLY A  44
ILE A  84
LEU A 163
 None
 1.09A 6dwnC-4o1jA:
undetectable		 6dwnC-4o1jA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN

(Streptomyces
pristinaespiralis) 		no annotation 5 ILE A 219
SER A  12
PHE A 297
GLY A 300
PHE A  55
 None
 1.10A 6dwnC-4okmA:
0.0		 6dwnC-4okmA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbo C-REACTIVE PROTEIN

(Danio rerio) 		PF00354
(Pentaxin) 		5 SER A 142
LEU A  22
ASP A 139
GLY A 137
PHE A  11
 None
 1.00A 6dwnC-4pboA:
undetectable		 6dwnC-4pboA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3f SPLICEOSOMAL PROTEIN
CWC27

(Chaetomium
thermophilum) 		PF00160
(Pro_isomerase) 		5 ILE A 192
ASN A  39
PHE A  40
GLY A  66
LEU A 124
 EDO  A 302 (-3.8A)
None
None
None
None
 1.07A 6dwnC-4r3fA:
undetectable		 6dwnC-4r3fA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmc OLD YELLOW ENZYME

(Kluyveromyces
marxianus) 		PF00724
(Oxidored_FMN) 		5 ILE A 166
ASN A 207
PHE A 201
GLY A 160
LEU A 197
 None
 1.14A 6dwnC-4tmcA:
undetectable		 6dwnC-4tmcA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		5 ILE A 491
LEU A 483
GLY A 449
ILE A 500
LEU A 503
 None
 1.04A 6dwnC-4u1rA:
undetectable		 6dwnC-4u1rA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uob ENDONUCLEASE III-3

(Deinococcus
radiodurans) 		PF00730
(HhH-GPD) 		5 ILE A 132
GLY A 126
PHE A 121
ILE A 167
LEU A 149
 None
ACT  A1333 (-3.1A)
ACT  A1333 ( 4.6A)
None
None
 1.05A 6dwnC-4uobA:
undetectable		 6dwnC-4uobA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wia PUTATIVE
FLAGELLA-RELATED
PROTEIN H

(Methanocaldococcus
jannaschii) 		PF06745
(ATPase) 		6 SER A  28
ASN A  54
PHE A  51
GLY A  23
ILE A  30
LEU A  47
 None
 1.42A 6dwnC-4wiaA:
undetectable		 6dwnC-4wiaA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A

(Pseudomonas
aeruginosa) 		PF06026
(Rib_5-P_isom_A) 		5 ILE A 120
ASN A  37
GLY A  31
ILE A  18
LEU A  43
 None
 1.08A 6dwnC-4x84A:
undetectable		 6dwnC-4x84A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 ILE A 139
SER A 212
LEU A  83
ILE A 216
LEU A 157
 None
 1.07A 6dwnC-4ysjA:
undetectable		 6dwnC-4ysjA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z11 AURONE SYNTHASE

(Coreopsis
grandiflora) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL)
PF12143
(PPO1_KFDV) 		5 ILE A 418
PHE A 428
GLY A 452
ILE A 507
LEU A 493
 None
 1.02A 6dwnC-4z11A:
undetectable		 6dwnC-4z11A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zys EXOTOXIN 6

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		5 ILE A  98
PHE A  90
ASN A  97
ILE A  80
LEU A  82
 None
 1.15A 6dwnC-4zysA:
undetectable		 6dwnC-4zysA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awp ISOMALTODEXTRANASE

(Arthrobacter
globiformis) 		no annotation 5 ASN A 214
PHE A 156
ASP A 197
ILE A  80
LEU A 165
 None
GLC  A 702 ( 4.9A)
BGC  A 701 (-3.0A)
GLC  A 702 (-4.1A)
None
 0.93A 6dwnC-5awpA:
undetectable		 6dwnC-5awpA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbz ENZYME SUBTILASE
SUBHAL FROM BACILLUS
HALMAPALUS

(Bacillus
halmapalus) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		5 ASN A 400
PHE A 299
GLY A 307
ILE A 179
LEU A 288
 None
 1.13A 6dwnC-5fbzA:
undetectable		 6dwnC-5fbzA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fcd MCCD

(Escherichia
coli) 		PF13649
(Methyltransf_25) 		5 ILE A 131
ASN A 139
LEU A 135
ILE A  79
LEU A 112
 None
None
CL  A 301 (-4.5A)
None
None
 1.14A 6dwnC-5fcdA:
undetectable		 6dwnC-5fcdA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmp UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF00063
(Myosin_head) 		5 ILE A 158
GLY A 432
PHE A 430
ILE A 436
LEU A 635
 None
 0.97A 6dwnC-5hmpA:
0.0		 6dwnC-5hmpA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5twb FERREDOXIN--NADP
REDUCTASE

(Staphylococcus
aureus) 		PF07992
(Pyr_redox_2) 		5 ILE A 218
LEU A 133
GLY A 127
ILE A 206
LEU A 123
 None
 1.12A 6dwnC-5twbA:
undetectable		 6dwnC-5twbA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5way TRANSCRIPTIONAL
ACTIVATOR

(Streptococcus
pneumoniae) 		PF05043
(Mga)
PF08270
(PRD_Mga)
PF08280
(HTH_Mga) 		5 ILE A 143
SER A 137
PHE A 213
GLY A 100
ILE A 121
 None
 1.03A 6dwnC-5wayA:
2.0		 6dwnC-5wayA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides) 		no annotation 5 ILE A 323
ASN A 258
PHE A 346
ILE A 296
LEU A 262
 None
 0.99A 6dwnC-5wypA:
undetectable		 6dwnC-5wypA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029

(Streptococcus
pneumoniae) 		no annotation 5 ILE A 403
LEU A 451
GLY A 399
ILE A 392
LEU A 423
 None
 1.15A 6dwnC-5xj1A:
undetectable		 6dwnC-5xj1A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyk PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		no annotation 5 LEU E 138
PHE E 210
GLY E 105
ILE E  80
LEU E 120
 None
 1.15A 6dwnC-5xykE:
undetectable		 6dwnC-5xykE:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE

(Escherichia
coli) 		no annotation 5 ILE A 196
LEU A 222
GLY A 174
ILE A 157
LEU A 266
 None
 1.15A 6dwnC-5z03A:
undetectable		 6dwnC-5z03A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 5 ILE A  75
LEU A  48
ASP A  82
PHE A  56
LEU A  92
 None
 1.15A 6dwnC-5zlnA:
undetectable		 6dwnC-5zlnA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia x
hybrida) 		no annotation 5 SER A  57
PHE A 174
ASP A  30
GLY A  28
PHE A  27
 None
None
None
None
TLF  A 300 (-3.8A)
 1.15A 6dwnC-6ap6A:
undetectable		 6dwnC-6ap6A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4c -

(-) 		no annotation 5 ILE A 100
PHE A  76
LEU A  77
GLY A 104
ILE A 160
 None
 1.12A 6dwnC-6b4cA:
undetectable		 6dwnC-6b4cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Neisseria
gonorrhoeae) 		no annotation 5 ILE A 262
PHE A 148
ASN A 250
ILE A 279
LEU A 144
 None
 1.01A 6dwnC-6bacA:
undetectable		 6dwnC-6bacA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dus TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN

(Salmonella
enterica) 		no annotation 5 LEU A 125
PHE A 197
GLY A  92
ILE A  67
LEU A 107
 None
 1.16A 6dwnC-6dusA:
undetectable		 6dwnC-6dusA:
undetectable