SIMILAR PATTERNS OF AMINO ACIDS FOR 6DWN_B_AQ4B602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czk FLAVODOXIN

(Synechococcus
elongatus) 		PF00258
(Flavodoxin_1) 		4 ASN A  38
GLY A  53
VAL A  31
LEU A  33
 None
 0.71A 6dwnB-1czkA:
undetectable		 6dwnB-1czkA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dab P.69 PERTACTIN

(Bordetella
pertussis) 		PF03212
(Pertactin) 		4 SER A  63
GLY A 125
ALA A 126
VAL A 240
 None
 0.85A 6dwnB-1dabA:
0.0		 6dwnB-1dabA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2p AMINOPEPTIDASE

(Streptomyces
griseus) 		PF04389
(Peptidase_M28) 		4 SER A 102
GLY A  94
ALA A  93
LEU A 253
 None
 0.80A 6dwnB-1f2pA:
0.0		 6dwnB-1f2pA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ih5 AQUAPORIN-1

(Homo sapiens) 		PF00230
(MIP) 		4 ASN A  76
GLY A 219
ALA A 221
LEU A  81
 None
 0.77A 6dwnB-1ih5A:
1.2		 6dwnB-1ih5A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mn6 POLYKETIDE SYNTHASE
IV

(Streptomyces
venezuelae) 		PF00975
(Thioesterase) 		4 PHE A  99
GLY A 150
ALA A 151
VAL A 232
 None
 0.74A 6dwnB-1mn6A:
undetectable		 6dwnB-1mn6A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt4 GLUCOSE-1-PHOSPHATAS
E

(Escherichia
coli) 		PF00328
(His_Phos_2) 		5 SER A  16
GLY A  61
ALA A 106
VAL A  74
LEU A  68
 None
 1.09A 6dwnB-1nt4A:
0.0		 6dwnB-1nt4A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5z FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE

(Thermotoga
maritima) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ASN A 292
GLY A 316
ALA A 317
VAL A 404
 SO4  A 502 (-3.1A)
None
None
None
 0.76A 6dwnB-1o5zA:
0.0		 6dwnB-1o5zA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ope SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE

(Sus scrofa) 		PF01144
(CoA_trans) 		4 SER A  66
ALA A  37
VAL A 203
LEU A 170
 None
 0.71A 6dwnB-1opeA:
undetectable		 6dwnB-1opeA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rp0 THIAZOLE
BIOSYNTHETIC ENZYME

(Arabidopsis
thaliana) 		PF01946
(Thi4) 		4 PHE A  98
GLY A  48
ALA A  47
LEU A 129
 None
AHZ  A 600 (-3.4A)
None
None
 0.72A 6dwnB-1rp0A:
0.0		 6dwnB-1rp0A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 PHE A 586
ALA A 464
VAL A 438
LEU A 442
 None
 0.73A 6dwnB-1u59A:
undetectable		 6dwnB-1u59A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uax RIBONUCLEASE HII

(Pyrococcus
horikoshii) 		PF01351
(RNase_HII) 		4 GLY A  10
ALA A   9
VAL A  65
LEU A  67
 None
 0.81A 6dwnB-1uaxA:
undetectable		 6dwnB-1uaxA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus) 		PF09231
(RDV-p3) 		4 GLY A 388
ALA A 389
VAL A 645
LEU A 641
 None
 0.82A 6dwnB-1uf2A:
undetectable		 6dwnB-1uf2A:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wac P2 PROTEIN

(Pseudomonas
virus phi6) 		PF00680
(RdRP_1) 		4 GLY A 197
ALA A 198
VAL A 389
LEU A 387
 None
 0.85A 6dwnB-1wacA:
undetectable		 6dwnB-1wacA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzh CYTOCHROME C
PEROXIDASE

(Rhodobacter
capsulatus) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		4 GLY A  37
ALA A  38
VAL A  60
LEU A 166
 None
 0.67A 6dwnB-1zzhA:
undetectable		 6dwnB-1zzhA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF03971
(IDH) 		4 SER A 655
ASN A 730
PHE A 729
VAL A  35
 None
 0.81A 6dwnB-2b0tA:
undetectable		 6dwnB-2b0tA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bih NITRATE REDUCTASE
[NADPH]

(Ogataea angusta) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 PHE A  65
GLY A 162
ALA A 161
LEU A  57
 None
 0.81A 6dwnB-2bihA:
undetectable		 6dwnB-2bihA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bjm IGE SPE7 HEAVY CHAIN

(Mus musculus) 		PF07686
(V-set) 		4 GLY H   8
ALA H   9
VAL H  18
LEU H  20
 None
 0.85A 6dwnB-2bjmH:
undetectable		 6dwnB-2bjmH:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cx9 ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A 258
ALA A  79
VAL A  26
LEU A  22
 None
 0.79A 6dwnB-2cx9A:
undetectable		 6dwnB-2cx9A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA

(Escherichia
coli) 		PF03054
(tRNA_Me_trans) 		4 PHE A 206
GLY A  93
ALA A  92
LEU A 214
 C  C  36 ( 4.0A)
None
None
None
 0.81A 6dwnB-2detA:
undetectable		 6dwnB-2detA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4i HYPOTHETICAL PROTEIN
TM0957

(Thermotoga
maritima) 		PF10054
(DUF2291) 		4 PHE A 146
GLY A 139
VAL A 163
LEU A 159
 MLY  A 142 ( 4.3A)
None
MLY  A 164 ( 3.1A)
None
 0.79A 6dwnB-2f4iA:
undetectable		 6dwnB-2f4iA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gup ROK FAMILY PROTEIN

(Streptococcus
pneumoniae) 		PF00480
(ROK) 		4 SER A  74
ASN A 102
VAL A  95
LEU A  97
 None
None
SUC  A 292 (-4.1A)
None
 0.80A 6dwnB-2gupA:
undetectable		 6dwnB-2gupA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB

(Methanocaldococcus
jannaschii) 		PF02492
(cobW) 		4 ASN A 110
ALA A  35
VAL A 102
LEU A 106
 None
 0.76A 6dwnB-2hf8A:
undetectable		 6dwnB-2hf8A:
15.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens) 		PF00067
(p450) 		4 PHE A 253
GLY A 316
ALA A 317
LEU A 497
 None
BHF  A 800 (-3.8A)
HEM  A 900 ( 3.5A)
BHF  A 800 (-4.4A)
 0.35A 6dwnB-2hi4A:
55.8		 6dwnB-2hi4A:
81.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hlw UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1

(Homo sapiens) 		PF00179
(UQ_con) 		4 ASN A 114
GLY A 121
VAL A 143
LEU A 147
 None
 0.84A 6dwnB-2hlwA:
undetectable		 6dwnB-2hlwA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jk0 L-ASPARAGINASE

(Pectobacterium
carotovorum) 		PF00710
(Asparaginase) 		4 SER A 299
PHE A 324
VAL A 211
LEU A 309
 None
 0.81A 6dwnB-2jk0A:
undetectable		 6dwnB-2jk0A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m8h RNA-BINDING PROTEIN
7

(Homo sapiens) 		PF00076
(RRM_1) 		4 GLY A  41
ALA A  40
VAL A  21
LEU A  19
 None
 0.79A 6dwnB-2m8hA:
undetectable		 6dwnB-2m8hA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		4 SER A 359
GLY A 398
VAL A 427
LEU A 409
 None
 0.83A 6dwnB-2oi6A:
undetectable		 6dwnB-2oi6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		4 PHE A 586
ALA A 464
VAL A 438
LEU A 442
 None
 0.70A 6dwnB-2ozoA:
undetectable		 6dwnB-2ozoA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE

(Lactococcus
lactis) 		PF00232
(Glyco_hydro_1) 		4 PHE A   9
GLY A  13
ALA A  14
VAL A 215
 None
 0.80A 6dwnB-2pbgA:
undetectable		 6dwnB-2pbgA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyv XAA-HIS DIPEPTIDASE

(Histophilus
somni) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 SER A 449
GLY A 432
ALA A 431
LEU A 368
 None
SO4  A 503 (-3.3A)
SO4  A 503 (-3.6A)
None
 0.80A 6dwnB-2qyvA:
undetectable		 6dwnB-2qyvA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uun C-PHYCOCYANIN
C-PHYCOCYANIN

(Leptolyngbya
sp.;
Leptolyngbya
sp.) 		PF00502
(Phycobilisome)
PF00502
(Phycobilisome) 		4 SER A 152
GLY A 102
ALA A 101
VAL B  19
 None
 0.81A 6dwnB-2uunA:
undetectable		 6dwnB-2uunA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn1 ALPHA-GALACTOSIDASE

(Lactobacillus
acidophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 SER A 228
GLY A 540
VAL A 519
LEU A 515
 None
 0.70A 6dwnB-2xn1A:
undetectable		 6dwnB-2xn1A:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu2 UPF0271 PROTEIN
PA4511

(Pseudomonas
aeruginosa) 		PF03746
(LamB_YcsF) 		4 ASN A 220
GLY A 192
ALA A 193
LEU A 180
 None
 0.65A 6dwnB-2xu2A:
undetectable		 6dwnB-2xu2A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6i TRANS-2-ENOYL-ACP
REDUCTASE II

(Streptococcus
pneumoniae) 		PF03060
(NMO) 		4 GLY A 169
ALA A 168
VAL A 157
LEU A 153
 FMN  A 401 (-3.3A)
FMN  A 401 ( 3.9A)
None
None
 0.81A 6dwnB-2z6iA:
undetectable		 6dwnB-2z6iA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP C

(Sulfurisphaera
tokodaii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 ASN C 230
GLY C  54
ALA C  53
LEU C  50
 None
 0.81A 6dwnB-3aizC:
undetectable		 6dwnB-3aizC:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dv9 BETA-PHOSPHOGLUCOMUT
ASE

(Bacteroides
vulgatus) 		PF13419
(HAD_2) 		4 GLY A 199
ALA A 198
VAL A 127
LEU A  24
 None
 0.79A 6dwnB-3dv9A:
undetectable		 6dwnB-3dv9A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff1 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Staphylococcus
aureus) 		PF00342
(PGI) 		4 PHE A  59
GLY A 218
ALA A 217
VAL A  78
 None
 0.84A 6dwnB-3ff1A:
undetectable		 6dwnB-3ff1A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g6l CHITINASE

(Clonostachys
rosea) 		PF00704
(Glyco_hydro_18) 		4 ASN A 236
GLY A 283
ALA A 228
VAL A 186
 None
 0.84A 6dwnB-3g6lA:
undetectable		 6dwnB-3g6lA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gux PUTATIVE
ZN-DEPENDENT
EXOPEPTIDASE

(Bacteroides
vulgatus) 		PF04389
(Peptidase_M28) 		4 ASN A 106
GLY A 150
ALA A 151
LEU A  76
 None
 0.73A 6dwnB-3guxA:
undetectable		 6dwnB-3guxA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjv MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Vibrio cholerae) 		PF00698
(Acyl_transf_1) 		4 GLY A  95
ALA A  94
VAL A 274
LEU A 277
 None
 0.78A 6dwnB-3hjvA:
undetectable		 6dwnB-3hjvA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn2 2-DEHYDROPANTOATE
2-REDUCTASE

(Geobacter
metallireducens) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 SER A 128
GLY A   9
ALA A   8
VAL A  56
LEU A  42
 None
 1.35A 6dwnB-3hn2A:
undetectable		 6dwnB-3hn2A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4s HISTIDINE TRIAD
PROTEIN

(Bradyrhizobium
japonicum) 		PF01230
(HIT) 		4 ASN A 115
ALA A 104
VAL A  60
LEU A  71
 None
 0.63A 6dwnB-3i4sA:
undetectable		 6dwnB-3i4sA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		4 PHE 3 654
GLY 3 548
VAL 3 615
LEU 3 351
 None
 0.75A 6dwnB-3i9v3:
undetectable		 6dwnB-3i9v3:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iq0 PUTATIVE RIBOKINASE
II

(Escherichia
coli) 		PF00294
(PfkB) 		4 SER A  56
ASN A 107
GLY A  36
ALA A  37
 None
 0.84A 6dwnB-3iq0A:
undetectable		 6dwnB-3iq0A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7y MS30

(Homo sapiens) 		PF00829
(Ribosomal_L21p) 		5 ASN s 280
GLY s 337
ALA s 340
VAL s  76
LEU s  80
 None
 1.48A 6dwnB-3j7ys:
undetectable		 6dwnB-3j7ys:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kln TRANSCRIPTIONAL
REGULATOR, LUXR
FAMILY

(Vibrio cholerae) 		PF00196
(GerE) 		4 ASN A 205
GLY A 173
ALA A 174
VAL A 190
 None
 0.84A 6dwnB-3klnA:
undetectable		 6dwnB-3klnA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngj DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Entamoeba
histolytica) 		PF01791
(DeoC) 		4 PHE A  66
GLY A 163
ALA A 164
VAL A 182
 None
 0.84A 6dwnB-3ngjA:
undetectable		 6dwnB-3ngjA:
15.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pm0 CYTOCHROME P450 1B1

(Homo sapiens) 		PF00067
(p450) 		6 SER A 127
PHE A 261
GLY A 329
ALA A 330
VAL A 395
LEU A 509
 BHF  A 800 ( 4.6A)
None
BHF  A 800 ( 4.0A)
HEM  A 900 ( 3.4A)
HEM  A 900 (-4.6A)
BHF  A 800 (-4.7A)
 0.55A 6dwnB-3pm0A:
48.1		 6dwnB-3pm0A:
58.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmo UDP-3-O-[3-HYDROXYMY
RISTOYL] GLUCOSAMINE
N-ACYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00132
(Hexapep)
PF04613
(LpxD) 		4 GLY A 178
ALA A 179
VAL A 173
LEU A 157
 None
 0.82A 6dwnB-3pmoA:
undetectable		 6dwnB-3pmoA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm2 PHOSPHOSERINE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00266
(Aminotran_5) 		5 ASN A 199
GLY A 250
ALA A  53
VAL A  69
LEU A 207
 None
 1.26A 6dwnB-3qm2A:
undetectable		 6dwnB-3qm2A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpq C1068 HEAVY CHAIN

(Homo sapiens;
Mus musculus) 		no annotation 4 GLY H   8
ALA H   9
VAL H  18
LEU H  20
 None
 0.80A 6dwnB-3qpqH:
undetectable		 6dwnB-3qpqH:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3quc INORGANIC
PYROPHOSPHATASE

(Bacteroides
thetaiotaomicron) 		PF13419
(HAD_2) 		4 GLY A 184
ALA A 183
VAL A 112
LEU A   9
 None
 0.78A 6dwnB-3qucA:
undetectable		 6dwnB-3qucA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5c LINA

(uncultured
organism) 		no annotation 4 GLY B  55
ALA B  56
VAL B  24
LEU B  64
 None
 0.85A 6dwnB-3s5cB:
undetectable		 6dwnB-3s5cB:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twd BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep) 		4 SER A 359
GLY A 398
VAL A 427
LEU A 409
 None
 0.82A 6dwnB-3twdA:
undetectable		 6dwnB-3twdA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxb UNCHARACTERIZED
PROTEIN

(Gallus gallus) 		PF00106
(adh_short) 		5 ASN A  95
GLY A 247
ALA A 248
VAL A 237
LEU A 206
 None
 1.27A 6dwnB-3wxbA:
undetectable		 6dwnB-3wxbA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zlb PHOSPHOGLYCERATE
KINASE

(Streptococcus
pneumoniae) 		PF00162
(PGK) 		4 GLY A 278
ALA A 277
VAL A 325
LEU A 297
 None
None
ANP  A1401 (-3.1A)
ANP  A1401 ( 4.7A)
 0.72A 6dwnB-3zlbA:
undetectable		 6dwnB-3zlbA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ASN A 417
GLY A 471
ALA A 470
VAL A 478
 None
 0.82A 6dwnB-3zz1A:
undetectable		 6dwnB-3zz1A:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a73 L-LACTATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY A  90
ALA A  91
VAL A 258
LEU A 262
 None
 0.85A 6dwnB-4a73A:
undetectable		 6dwnB-4a73A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASN A 256
GLY A 237
VAL A 191
LEU A 193
 None
 0.67A 6dwnB-4akoA:
undetectable		 6dwnB-4akoA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akv SORTING NEXIN-33

(Homo sapiens) 		PF00787
(PX)
PF10456
(BAR_3_WASP_bdg) 		4 ASN A 481
GLY A 355
ALA A 356
LEU A 488
 None
 0.80A 6dwnB-4akvA:
undetectable		 6dwnB-4akvA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8w GDP-L-FUCOSE
SYNTHASE

(Homo sapiens) 		PF01370
(Epimerase) 		4 ASN A  96
GLY A  14
VAL A  61
LEU A  57
 None
NAP  A 900 (-3.0A)
None
None
 0.74A 6dwnB-4b8wA:
undetectable		 6dwnB-4b8wA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccd GALACTOCEREBROSIDASE

(Mus musculus) 		PF02057
(Glyco_hydro_59)
PF17387
(Glyco_hydro_59M) 		4 SER A 136
GLY A  49
ALA A  50
VAL A  56
 None
 0.84A 6dwnB-4ccdA:
undetectable		 6dwnB-4ccdA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecm GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Bacillus
anthracis) 		PF00483
(NTP_transferase) 		4 ASN A  99
GLY A 128
ALA A 129
VAL A 104
 None
 0.83A 6dwnB-4ecmA:
undetectable		 6dwnB-4ecmA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqb SPERMIDINE/PUTRESCIN
E ABC SUPERFAMILY
ATP BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF13416
(SBP_bac_8) 		4 ASN A 191
GLY A 342
VAL A 202
LEU A 179
 None
 0.69A 6dwnB-4eqbA:
undetectable		 6dwnB-4eqbA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0u ALLOPHYCOCYANIN
ALPHA CHAIN

(Synechococcus
elongatus) 		PF00502
(Phycobilisome) 		4 SER A 121
GLY A 114
VAL A 169
LEU A 173
 None
 0.74A 6dwnB-4f0uA:
undetectable		 6dwnB-4f0uA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASN A  73
GLY A  52
VAL A  26
LEU A  28
 None
 0.83A 6dwnB-4f7kA:
undetectable		 6dwnB-4f7kA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fuu LEUCINE
AMINOPEPTIDASE

(Bacteroides
thetaiotaomicron) 		PF04389
(Peptidase_M28) 		4 ASN A 106
GLY A 150
ALA A 151
LEU A  76
 None
 0.69A 6dwnB-4fuuA:
undetectable		 6dwnB-4fuuA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE

(Saccharomyces
cerevisiae) 		PF07992
(Pyr_redox_2) 		4 ASN A 406
GLY A  64
ALA A  65
VAL A  79
 ASN  A 406 ( 0.6A)
GLY  A  64 (-0.0A)
ALA  A  65 ( 0.0A)
VAL  A  79 ( 0.6A)
 0.85A 6dwnB-4g9kA:
undetectable		 6dwnB-4g9kA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq9 CHIKUNGUNYA VIRUS
NEUTRALIZING
ANTIBODY 9.8B FAB
FRAGMENT HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H   8
ALA H   9
VAL H  18
LEU H  20
 None
 0.84A 6dwnB-4gq9H:
undetectable		 6dwnB-4gq9H:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gs3 SINGLE-STRANDED
DNA-BINDING PROTEIN

(Caldanaerobacter
subterraneus) 		PF00436
(SSB) 		4 ASN A  34
GLY A  73
VAL A  39
LEU A  37
 None
 0.83A 6dwnB-4gs3A:
undetectable		 6dwnB-4gs3A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2

(Streptococcus
pneumoniae) 		PF12849
(PBP_like_2) 		4 SER A 193
PHE A 165
GLY A  47
VAL A  83
 None
None
CIT  A 302 (-3.2A)
None
 0.83A 6dwnB-4h1xA:
undetectable		 6dwnB-4h1xA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hds ARSA

(Sporomusa ovata) 		PF02277
(DBI_PRT) 		4 SER A 184
GLY A 246
ALA A 249
VAL A 262
 None
 0.78A 6dwnB-4hdsA:
undetectable		 6dwnB-4hdsA:
12.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		7 SER A 116
ASN A 223
PHE A 251
GLY A 316
ALA A 317
VAL A 382
LEU A 496
 BHF  A 602 (-3.2A)
None
None
BHF  A 602 (-3.5A)
BHF  A 602 ( 3.4A)
HEM  A 601 (-4.9A)
None
 0.38A 6dwnB-4i8vA:
61.1		 6dwnB-4i8vA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irx SUGAR ABC
TRANSPORTER,
PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Caulobacter
vibrioides) 		PF13407
(Peripla_BP_4) 		4 ASN A 168
ALA A 274
VAL A 226
LEU A 228
 INS  A 401 (-3.8A)
None
None
None
 0.75A 6dwnB-4irxA:
undetectable		 6dwnB-4irxA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3o OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF00577
(Usher)
PF13953
(PapC_C)
PF13954
(PapC_N) 		4 ASN D 670
GLY D 691
VAL D 676
LEU D 702
 None
 0.71A 6dwnB-4j3oD:
undetectable		 6dwnB-4j3oD:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1

(Staphylococcus
aureus) 		PF13614
(AAA_31) 		4 GLY A1125
ALA A1124
VAL A1075
LEU A1121
 None
 0.79A 6dwnB-4jlvA:
undetectable		 6dwnB-4jlvA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k02 1,4-DIHYDROXY-2-NAPH
THOYL-COA
THIOESTERASE

(Arabidopsis
thaliana) 		PF03061
(4HBT) 		4 ASN A  81
GLY A  50
VAL A  92
LEU A 112
 None
 0.82A 6dwnB-4k02A:
undetectable		 6dwnB-4k02A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A

(Pseudomonas
aeruginosa) 		PF06026
(Rib_5-P_isom_A) 		4 GLY A  52
ALA A  53
VAL A 110
LEU A  80
 None
 0.81A 6dwnB-4x84A:
undetectable		 6dwnB-4x84A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE

(Bacillus cereus) 		PF05547
(Peptidase_M6) 		5 SER A 334
PHE A 377
GLY A 317
ALA A 316
LEU A 170
 None
 1.42A 6dwnB-4yu5A:
undetectable		 6dwnB-4yu5A:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zn2 PSLG

(Pseudomonas
aeruginosa) 		PF00150
(Cellulase) 		4 ASN A 261
GLY A 205
ALA A 204
VAL A 227
 None
 0.77A 6dwnB-4zn2A:
undetectable		 6dwnB-4zn2A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
FAD-BINDING SUBUNIT

(Sulfurisphaera
tokodaii) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 ASN B 248
GLY B 221
ALA B 222
VAL B 191
LEU B 209
 None
 1.48A 6dwnB-4zohB:
undetectable		 6dwnB-4zohB:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)

(Bdellovibrio
bacteriovorus) 		PF06963
(FPN1) 		4 SER A 109
PHE A  39
GLY A 105
ALA A 104
 None
OLC  A 503 (-4.2A)
None
OLC  A 509 (-3.6A)
 0.74A 6dwnB-5aynA:
undetectable		 6dwnB-5aynA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2d HN PROTEIN

(Mumps
rubulavirus) 		PF00423
(HN) 		4 ASN A 391
GLY A 299
VAL A 396
LEU A 394
 None
 0.75A 6dwnB-5b2dA:
undetectable		 6dwnB-5b2dA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck7 ADP-DEPENDENT
GLUCOKINASE

(Mus musculus) 		PF04587
(ADP_PFK_GK) 		4 SER A 320
GLY A 486
ALA A 401
VAL A 451
 None
 0.78A 6dwnB-5ck7A:
undetectable		 6dwnB-5ck7A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eoc FAB FRAGMENT (HEAVY
CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H   8
ALA H   9
VAL H  18
LEU H  20
 None
 0.74A 6dwnB-5eocH:
undetectable		 6dwnB-5eocH:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hha PVDO

(Pseudomonas
aeruginosa) 		PF03781
(FGE-sulfatase) 		4 GLY A 162
ALA A 161
VAL A  41
LEU A  43
 None
 0.81A 6dwnB-5hhaA:
undetectable		 6dwnB-5hhaA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ho9 EXTRACELLULAR
ARABINANASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 SER A 541
GLY A 544
ALA A 531
VAL A 452
 None
 0.68A 6dwnB-5ho9A:
undetectable		 6dwnB-5ho9A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hw3 BETA-LACTAMASE

(Burkholderia
vietnamiensis) 		PF13354
(Beta-lactamase2) 		4 SER A 163
GLY A 144
ALA A 143
VAL A  95
 None
None
None
SO4  A 306 ( 3.7A)
 0.84A 6dwnB-5hw3A:
undetectable		 6dwnB-5hw3A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m31 APPR-1-P PROCESSING
DOMAIN PROTEIN

(Thermus
aquaticus) 		PF01661
(Macro) 		4 ASN A  19
GLY A  95
VAL A 144
LEU A 113
 None
 0.83A 6dwnB-5m31A:
undetectable		 6dwnB-5m31A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0g PRECORRIN-8X
METHYLMUTASE

(Rhodobacter
capsulatus) 		no annotation 4 GLY A 129
ALA A 130
VAL A 201
LEU A  67
 None
 0.82A 6dwnB-5n0gA:
undetectable		 6dwnB-5n0gA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4

(Homo sapiens) 		no annotation 4 ASN A 378
GLY A 311
VAL A 345
LEU A 341
 None
EDO  A 601 ( 3.8A)
None
None
 0.69A 6dwnB-5nqaA:
undetectable		 6dwnB-5nqaA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4

(Homo sapiens) 		no annotation 4 ASN A 378
GLY A 312
VAL A 345
LEU A 341
 None
EDO  A 612 ( 3.2A)
None
None
 0.73A 6dwnB-5nqaA:
undetectable		 6dwnB-5nqaA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ns8 -

(-) 		no annotation 4 ASN A 384
GLY A 391
VAL A 336
LEU A 333
 None
 0.77A 6dwnB-5ns8A:
undetectable		 6dwnB-5ns8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ook PHYCOCYANIN, ALPHA
SUBUNIT
PHYCOCYANIN, BETA
SUBUNIT

(Acaryochloris
marina;
Acaryochloris
marina) 		no annotation
no annotation 		4 SER A 164
GLY A 102
ALA A 101
VAL B  19
 PEG  A 204 (-3.5A)
None
None
None
 0.85A 6dwnB-5ookA:
undetectable		 6dwnB-5ookA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE

(Azospirillum
brasilense) 		no annotation 4 GLY A 127
ALA A 128
VAL A 135
LEU A  68
 ADP  A 301 (-3.0A)
None
None
None
 0.77A 6dwnB-5ovoA:
undetectable		 6dwnB-5ovoA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y50 PROTEIN
DETOXIFICATION 14

(Arabidopsis
thaliana) 		no annotation 4 GLY A 207
ALA A 208
VAL A  70
LEU A 153
 None
 0.84A 6dwnB-5y50A:
2.0		 6dwnB-5y50A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bn2 ACETYL-COA
ACETYLTRANSFERASE

(Elizabethkingia
anophelis) 		no annotation 4 ASN A 117
GLY A 141
VAL A  87
LEU A 350
 None
None
SCY  A  88 ( 2.8A)
SCY  A  88 ( 3.9A)
 0.85A 6dwnB-6bn2A:
undetectable		 6dwnB-6bn2A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ci7 YCAO

(Methanopyrus
kandleri) 		no annotation 5 SER A 171
GLY A 237
ALA A 245
VAL A 187
LEU A 185
 None
 1.22A 6dwnB-6ci7A:
undetectable		 6dwnB-6ci7A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejf -

(-) 		no annotation 4 GLY G 403
ALA G 404
VAL G 444
LEU G 448
 None
 0.65A 6dwnB-6ejfG:
undetectable		 6dwnB-6ejfG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwh IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Acanthamoeba
castellanii) 		no annotation 5 PHE A 169
GLY A  77
ALA A 147
VAL A 180
LEU A 176
 None
 1.35A 6dwnB-6fwhA:
undetectable		 6dwnB-6fwhA:
undetectable