SIMILAR PATTERNS OF AMINO ACIDS FOR 6DWN_B_AQ4B602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5f PROTEIN (CARDOSIN A)

(Cynara
cardunculus) 		PF00026
(Asp) 		5 ILE A 132
SER A  36
ASN A  67
PHE A  84
ILE A  73
 None
None
NAG  A 401 ( 1.8A)
NAG  A 401 ( 3.9A)
None
 1.37A 6dwnB-1b5fA:
undetectable		 6dwnB-1b5fA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewx TRYPAREDOXIN I

(Crithidia
fasciculata) 		PF13905
(Thioredoxin_8) 		5 SER A 119
LEU A 112
PHE A  32
ASP A 116
ASP A 144
 None
 1.44A 6dwnB-1ewxA:
undetectable		 6dwnB-1ewxA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6f PLACENTAL LACTOGEN

(Ovis aries) 		PF00103
(Hormone_1) 		5 LEU A  18
PHE A  22
PHE A  83
ASP A  79
ILE A  75
 None
 1.32A 6dwnB-1f6fA:
undetectable		 6dwnB-1f6fA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 ILE A 347
SER A 343
LEU A 421
PHE A 600
ASP A 605
 None
 1.32A 6dwnB-1g8xA:
0.0		 6dwnB-1g8xA:
5.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gmi PROTEIN KINASE C,
EPSILON TYPE

(Rattus rattus) 		PF00168
(C2) 		5 ILE A  79
LEU A 106
PHE A   4
ASP A 130
ILE A  12
 None
 0.85A 6dwnB-1gmiA:
undetectable		 6dwnB-1gmiA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iay 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
SYNTHASE 2

(Solanum
lycopersicum) 		PF00155
(Aminotran_1_2) 		5 ASN A 360
PHE A 365
PHE A 415
PHE A 245
ILE A 239
 None
None
None
None
PLP  A 500 (-4.6A)
 1.48A 6dwnB-1iayA:
0.0		 6dwnB-1iayA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw3 MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		5 ILE A 544
SER A 539
LEU A 505
PHE A 445
PHE A 480
 None
 1.43A 6dwnB-1lw3A:
0.0		 6dwnB-1lw3A:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mky PROBABLE GTP-BINDING
PROTEIN ENGA

(Thermotoga
maritima) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		5 ILE A 365
PHE A 399
ASN A 366
PHE A 386
ILE A 431
 None
 1.33A 6dwnB-1mkyA:
undetectable		 6dwnB-1mkyA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v33 DNA PRIMASE SMALL
SUBUNIT

(Pyrococcus
horikoshii) 		PF01896
(DNA_primase_S) 		5 ILE A  63
LEU A 297
PHE A  14
ASP A  23
ILE A  56
 None
 1.44A 6dwnB-1v33A:
0.0		 6dwnB-1v33A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x8v CYTOCHROME P450 51

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 ILE A 153
PHE A 250
LEU A 100
ASP A 224
ILE A 208
 None
 1.38A 6dwnB-1x8vA:
31.5		 6dwnB-1x8vA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsq MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		5 ILE A 544
SER A 539
LEU A 505
PHE A 445
PHE A 480
 None
 1.42A 6dwnB-1zsqA:
undetectable		 6dwnB-1zsqA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zwt MAJOR STRUCTURAL
SUBUNIT OF
BUNDLE-FORMING PILUS

(Escherichia
coli) 		PF05307
(Bundlin) 		5 ILE A  42
SER A  40
LEU A  84
ASN A  70
ASP A  39
 None
 1.37A 6dwnB-1zwtA:
undetectable		 6dwnB-1zwtA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1l RESTRICTION
ENDONUCLEASE

(Bacillus firmus) 		PF13091
(PLDc_2) 		5 ILE A 304
PHE A 237
PHE A 342
ASP A 236
ILE A 257
 None
 1.47A 6dwnB-2c1lA:
undetectable		 6dwnB-2c1lA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cje DUTPASE

(Leishmania
major) 		PF08761
(dUTPase_2) 		5 ASN A 183
LEU A  24
ASN A  25
ASP A  79
ILE A 157
 DUN  A1266 (-3.1A)
DUN  A1266 (-4.4A)
DUN  A1266 (-3.7A)
MG  A1268 ( 3.0A)
None
 1.45A 6dwnB-2cjeA:
undetectable		 6dwnB-2cjeA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fea 2-HYDROXY-3-KETO-5-M
ETHYLTHIOPENTENYL-1-
PHOSPHATE
PHOSPHATASE

(Bacillus
subtilis) 		PF12710
(HAD) 		5 ILE A  67
SER A  61
PHE A 104
LEU A  72
ASP A 103
 None
 1.49A 6dwnB-2feaA:
undetectable		 6dwnB-2feaA:
20.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens) 		PF00067
(p450) 		7 ILE A 117
PHE A 226
ASN A 257
ASP A 313
ASP A 320
ILE A 386
LYS A 500
 None
BHF  A 800 (-3.6A)
None
BHF  A 800 (-3.9A)
BHF  A 800 (-4.0A)
HEM  A 900 (-4.0A)
None
 0.65A 6dwnB-2hi4A:
55.8		 6dwnB-2hi4A:
81.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens) 		PF00067
(p450) 		6 ILE A 117
PHE A 226
ASN A 257
PHE A 260
ASP A 320
LYS A 500
 None
BHF  A 800 (-3.6A)
None
BHF  A 800 (-3.6A)
BHF  A 800 (-4.0A)
None
 0.92A 6dwnB-2hi4A:
55.8		 6dwnB-2hi4A:
81.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens) 		PF00067
(p450) 		5 PHE A 226
LEU A 219
ASP A 313
ILE A 386
LYS A 500
 BHF  A 800 (-3.6A)
None
BHF  A 800 (-3.9A)
HEM  A 900 (-4.0A)
None
 1.44A 6dwnB-2hi4A:
55.8		 6dwnB-2hi4A:
81.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j89 METHIONINE SULFOXIDE
REDUCTASE A

(Populus
trichocarpa) 		PF01625
(PMSR) 		5 ILE A 159
SER A 131
LEU A 154
ASP A 107
ILE A 133
 None
 1.39A 6dwnB-2j89A:
undetectable		 6dwnB-2j89A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)

(Homo sapiens) 		no annotation 5 ASN A 361
PHE A 405
LEU A 358
ASN A 399
ILE A 133
 None
 1.48A 6dwnB-2jdxA:
undetectable		 6dwnB-2jdxA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l3f UNCHARACTERIZED
PROTEIN

(Methanosarcina
acetivorans) 		PF03167
(UDG) 		5 ILE A  18
ASN A  39
PHE A  41
ASN A 113
ILE A  49
 None
 1.47A 6dwnB-2l3fA:
undetectable		 6dwnB-2l3fA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE

(Arabidopsis
thaliana) 		PF01487
(DHquinase_I)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 ILE A 267
SER A 212
LEU A  95
ASP A 186
ILE A 232
 None
 1.25A 6dwnB-2o7qA:
undetectable		 6dwnB-2o7qA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odp COMPLEMENT C2

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		5 SER A 256
LEU A 406
PHE A 278
ASP A 240
ILE A 252
 None
None
None
MG  A 901 ( 3.9A)
None
 1.49A 6dwnB-2odpA:
undetectable		 6dwnB-2odpA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1

(Sulfolobus
solfataricus) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		5 ILE A 159
PHE A 151
ASN A 156
ASP A  99
ILE A  93
 None
 1.30A 6dwnB-2qbyA:
undetectable		 6dwnB-2qbyA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rch CYTOCHROME P450 74A

(Arabidopsis
thaliana) 		PF00067
(p450) 		5 ILE A 497
PHE A 495
LEU A 197
PHE A 209
PHE A 484
 None
 1.24A 6dwnB-2rchA:
28.4		 6dwnB-2rchA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK) 		PF00202
(Aminotran_3) 		5 LEU A 352
ASN A 351
PHE A 348
ASP A 423
PHE A  85
 None
 1.17A 6dwnB-2ykyA:
undetectable		 6dwnB-2ykyA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 532
ASN A 530
ASP A 502
PHE A 516
ILE A 454
 None
 1.25A 6dwnB-2z63A:
undetectable		 6dwnB-2z63A:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF03480
(DctP) 		5 ILE A 159
LEU A 226
ASN A 223
PHE A 217
PHE A  98
 None
None
None
LAC  A 401 ( 4.6A)
LAC  A 401 (-4.0A)
 1.42A 6dwnB-2zzwA:
undetectable		 6dwnB-2zzwA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		5 ILE A 575
SER A 560
PHE A 577
ASP A 715
PHE A 707
 None
 1.50A 6dwnB-3ahiA:
undetectable		 6dwnB-3ahiA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzm MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Escherichia
coli) 		PF00425
(Chorismate_bind) 		5 ILE A  70
LEU A  67
PHE A 143
ASP A 136
ILE A  25
 None
 1.43A 6dwnB-3bzmA:
undetectable		 6dwnB-3bzmA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cij UPF0100 PROTEIN
AF_0094

(Archaeoglobus
fulgidus) 		PF13531
(SBP_bac_11) 		5 ILE A 205
SER A 184
LEU A 272
ASN A 151
ILE A 212
 None
 1.34A 6dwnB-3cijA:
undetectable		 6dwnB-3cijA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db2 PUTATIVE
NADPH-DEPENDENT
OXIDOREDUCTASE

(Desulfitobacterium
hafniense) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ILE A  98
LEU A 334
ASP A 109
ASP A 103
ILE A  82
 None
 1.44A 6dwnB-3db2A:
undetectable		 6dwnB-3db2A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec2 DNA REPLICATION
PROTEIN DNAC

(Aquifex
aeolicus) 		PF01695
(IstB_IS21) 		5 ILE A 211
LEU A  82
ASN A 215
ASP A 148
ILE A 163
 None
None
None
MG  A 300 (-3.7A)
None
 1.49A 6dwnB-3ec2A:
undetectable		 6dwnB-3ec2A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn5 SORTASE A

(Streptococcus
pyogenes) 		PF04203
(Sortase) 		5 ASN A 241
PHE A 240
LEU A 237
ASP A 171
ILE A 109
 None
 1.34A 6dwnB-3fn5A:
undetectable		 6dwnB-3fn5A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h14 AMINOTRANSFERASE,
CLASSES I AND II

(Ruegeria
pomeroyi) 		PF00155
(Aminotran_1_2) 		5 ILE A 198
PHE A 108
LEU A 106
ASP A 200
ILE A 120
 None
 1.42A 6dwnB-3h14A:
undetectable		 6dwnB-3h14A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hh8 METAL ABC
TRANSPORTER
SUBSTRATE-BINDING
LIPOPROTEIN

(Streptococcus
pyogenes) 		PF01297
(ZnuA) 		5 ILE A 277
LEU A 300
ASN A 299
PHE A 211
ILE A 273
 None
 1.44A 6dwnB-3hh8A:
undetectable		 6dwnB-3hh8A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikb UNCHARACTERIZED
CONSERVED PROTEIN

(Streptococcus
mutans) 		PF03167
(UDG) 		5 ILE A  11
PHE A 104
ASN A  17
PHE A  20
ILE A 112
 None
 1.02A 6dwnB-3ikbA:
undetectable		 6dwnB-3ikbA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktc XYLOSE ISOMERASE

(Pectobacterium
atrosepticum) 		PF01261
(AP_endonuc_2) 		5 ILE A 219
LEU A 258
PHE A 254
ASP A 229
ILE A 165
 None
None
None
FE  A 334 (-3.1A)
None
 1.33A 6dwnB-3ktcA:
undetectable		 6dwnB-3ktcA:
13.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pm0 CYTOCHROME P450 1B1

(Homo sapiens) 		PF00067
(p450) 		7 PHE A 231
ASN A 265
PHE A 268
ASP A 326
ASP A 333
ILE A 399
LYS A 512
 BHF  A 800 (-3.4A)
None
BHF  A 800 ( 3.8A)
BHF  A 800 (-3.4A)
BHF  A 800 ( 4.1A)
HEM  A 900 (-4.0A)
None
 0.81A 6dwnB-3pm0A:
48.1		 6dwnB-3pm0A:
58.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pm0 CYTOCHROME P450 1B1

(Homo sapiens) 		PF00067
(p450) 		5 SER A 131
LEU A 224
ASP A 326
ASP A 333
LYS A 512
 BHF  A 800 ( 4.7A)
None
BHF  A 800 (-3.4A)
BHF  A 800 ( 4.1A)
None
 1.43A 6dwnB-3pm0A:
48.1		 6dwnB-3pm0A:
58.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psg PEPSINOGEN

(Sus scrofa) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		5 ILE A 275
SER A 251
LEU A 221
PHE A 286
ASP A 257
 None
 1.41A 6dwnB-3psgA:
undetectable		 6dwnB-3psgA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r08 MOUSE ANTI-MOUSE
CD3EPSILON ANTIBODY
2C11 LIGHT CHAIN

(Cricetulus
migratorius) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU L 175
ASN L 137
PHE L 139
ASP L 170
ASP L 165
 None
 1.44A 6dwnB-3r08L:
undetectable		 6dwnB-3r08L:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ve9 OROTIDINE-5'-PHOSPHA
TE DECARBOXYLASE

(Metallosphaera
sedula) 		PF00215
(OMPdecase) 		5 ILE A 155
PHE A 102
LEU A 103
PHE A 132
ASP A 175
 None
 1.35A 6dwnB-3ve9A:
undetectable		 6dwnB-3ve9A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtg HIGH CHORIOLYTIC
ENZYME 1

(Oryzias latipes) 		PF01400
(Astacin) 		5 ILE A 152
SER A 150
LEU A 105
ASN A 102
PHE A 107
 None
 1.32A 6dwnB-3vtgA:
undetectable		 6dwnB-3vtgA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zi5 RESTRICTION
ENDONUCLEASE

(Bacillus firmus) 		no annotation 5 ILE A 304
PHE A 237
PHE A 342
ASP A 236
ILE A 257
 None
 1.45A 6dwnB-3zi5A:
undetectable		 6dwnB-3zi5A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b7g CATALASE

(Corynebacterium
glutamicum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 ILE A 140
SER A 212
LEU A 104
PHE A 311
PHE A 108
 None
HEM  A3000 (-3.5A)
None
None
None
 1.37A 6dwnB-4b7gA:
undetectable		 6dwnB-4b7gA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8) 		no annotation 5 ILE A 289
LEU A 285
PHE A 366
ASP A 191
ILE A 503
 None
 1.39A 6dwnB-4btpA:
undetectable		 6dwnB-4btpA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA

(Drosophila
melanogaster;
Eptatretus
burgeri) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 SER R 348
LEU R 402
ASN R 400
ASP R 372
PHE R 386
 None
 1.36A 6dwnB-4bv4R:
undetectable		 6dwnB-4bv4R:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 ILE A 685
LEU A 723
PHE A 735
PHE A 977
ASP A 978
 None
 1.45A 6dwnB-4crsA:
undetectable		 6dwnB-4crsA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewc PUTATIVE
NUCLEOPROTEIN

(Salmon isavirus) 		no annotation 5 ILE A 387
PHE A 148
LEU A 177
PHE A 143
ILE A 415
 None
 1.16A 6dwnB-4ewcA:
undetectable		 6dwnB-4ewcA:
9.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		5 ILE A 115
ASN A 223
PHE A 224
ASN A 255
ILE A 386
 BHF  A 602 (-4.7A)
None
BHF  A 602 (-3.3A)
None
HEM  A 601 (-3.6A)
 1.34A 6dwnB-4i8vA:
61.1		 6dwnB-4i8vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		8 ILE A 115
SER A 122
ASN A 222
LEU A 254
ASN A 255
PHE A 258
ASP A 313
PHE A 319
 BHF  A 602 (-4.7A)
HEM  A 601 (-3.4A)
BHF  A 602 ( 3.8A)
None
None
BHF  A 602 ( 3.9A)
BHF  A 602 (-3.7A)
BHF  A 602 ( 4.7A)
 0.90A 6dwnB-4i8vA:
61.1		 6dwnB-4i8vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		9 ILE A 115
SER A 122
ASN A 222
PHE A 224
ASN A 255
PHE A 258
ASP A 313
PHE A 319
ILE A 386
 BHF  A 602 (-4.7A)
HEM  A 601 (-3.4A)
BHF  A 602 ( 3.8A)
BHF  A 602 (-3.3A)
None
BHF  A 602 ( 3.9A)
BHF  A 602 (-3.7A)
BHF  A 602 ( 4.7A)
HEM  A 601 (-3.6A)
 0.75A 6dwnB-4i8vA:
61.1		 6dwnB-4i8vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		9 ILE A 115
SER A 122
PHE A 224
ASN A 255
ASP A 313
PHE A 319
ASP A 320
ILE A 386
LYS A 499
 BHF  A 602 (-4.7A)
HEM  A 601 (-3.4A)
BHF  A 602 (-3.3A)
None
BHF  A 602 (-3.7A)
BHF  A 602 ( 4.7A)
BHF  A 602 (-3.7A)
HEM  A 601 (-3.6A)
None
 0.44A 6dwnB-4i8vA:
61.1		 6dwnB-4i8vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		9 ILE A 115
SER A 122
PHE A 224
ASN A 255
PHE A 258
ASP A 313
PHE A 319
ASP A 320
ILE A 386
 BHF  A 602 (-4.7A)
HEM  A 601 (-3.4A)
BHF  A 602 (-3.3A)
None
BHF  A 602 ( 3.9A)
BHF  A 602 (-3.7A)
BHF  A 602 ( 4.7A)
BHF  A 602 (-3.7A)
HEM  A 601 (-3.6A)
 0.57A 6dwnB-4i8vA:
61.1		 6dwnB-4i8vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		5 SER A 122
LEU A 217
ASP A 313
ASP A 320
LYS A 499
 HEM  A 601 (-3.4A)
None
BHF  A 602 (-3.7A)
BHF  A 602 (-3.7A)
None
 1.35A 6dwnB-4i8vA:
61.1		 6dwnB-4i8vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		5 SER A 122
PHE A 315
ASP A 313
ASP A 320
LYS A 499
 HEM  A 601 (-3.4A)
None
BHF  A 602 (-3.7A)
BHF  A 602 (-3.7A)
None
 1.44A 6dwnB-4i8vA:
61.1		 6dwnB-4i8vA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifr 2-AMINO-3-CARBOXYMUC
ONATE 6-SEMIALDEHYDE
DECARBOXYLASE

(Pseudomonas
fluorescens) 		PF04909
(Amidohydro_2) 		5 ILE A 224
LEU A 118
PHE A 330
ASP A 268
ILE A 206
 None
 1.22A 6dwnB-4ifrA:
undetectable		 6dwnB-4ifrA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igg CATENIN ALPHA-1

(Homo sapiens) 		PF01044
(Vinculin) 		5 LEU A 364
ASN A 365
PHE A 301
ASP A 292
ILE A 792
 None
 1.45A 6dwnB-4iggA:
undetectable		 6dwnB-4iggA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k17 LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A

(Mus musculus) 		PF13516
(LRR_6) 		5 LEU A 214
PHE A 159
ASP A 183
PHE A 199
ASP A 198
 None
 1.45A 6dwnB-4k17A:
undetectable		 6dwnB-4k17A:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjy LEUKOCYTE SURFACE
ANTIGEN CD47
HIGH-AFFINITY SIRPA
VARIANT FD6

(Homo sapiens;
Homo sapiens) 		PF08204
(V-set_CD47)
PF07686
(V-set) 		5 ILE B  36
LEU B  48
PHE B  39
ASP B 100
LYS A  39
 None
 1.32A 6dwnB-4kjyB:
undetectable		 6dwnB-4kjyB:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt1 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 SER A 371
LEU A 425
ASN A 423
ASP A 395
PHE A 409
 None
 1.38A 6dwnB-4kt1A:
undetectable		 6dwnB-4kt1A:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 ILE A 289
ASN A 389
LEU A 305
ASN A 290
ILE A 322
 None
 1.29A 6dwnB-4lq1A:
undetectable		 6dwnB-4lq1A:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxr PROTEIN TOLL

(Drosophila
melanogaster) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 SER A 348
LEU A 402
ASN A 400
ASP A 372
PHE A 386
 None
 1.37A 6dwnB-4lxrA:
undetectable		 6dwnB-4lxrA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lyp EXO-BETA-1,4-MANNOSI
DASE

(Rhizomucor
miehei) 		no annotation 5 ILE A 218
SER A 228
ASN A 166
PHE A 123
ILE A 249
 None
 1.35A 6dwnB-4lypA:
undetectable		 6dwnB-4lypA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4msx PRE-MRNA-SPLICING
FACTOR SAD1

(Saccharomyces
cerevisiae) 		PF00443
(UCH)
PF02148
(zf-UBP) 		5 ILE A 200
LEU A 193
PHE A 215
PHE A 235
ILE A 421
 None
 1.49A 6dwnB-4msxA:
undetectable		 6dwnB-4msxA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mup AMIDOHYDROLASE

(Agrobacterium
fabrum) 		PF04909
(Amidohydro_2) 		5 ILE A  96
LEU A  81
ASN A  77
ASP A  98
ILE A 119
 None
 1.44A 6dwnB-4mupA:
undetectable		 6dwnB-4mupA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtu PUTATIVE
METHYLTRANSFERASE
BUD23

(Saccharomyces
cerevisiae) 		PF08241
(Methyltransf_11) 		5 ILE B 117
LEU B 197
PHE B 154
ASP B  53
PHE B 140
 SAM  B 301 (-4.2A)
None
None
SAM  B 301 ( 4.6A)
None
 1.30A 6dwnB-4qtuB:
undetectable		 6dwnB-4qtuB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		5 ILE A1780
ASN A1700
LEU A1698
ASN A1727
ASP A1731
 None
 1.15A 6dwnB-4r04A:
undetectable		 6dwnB-4r04A:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rye D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Mycobacterium
tuberculosis) 		PF00768
(Peptidase_S11) 		5 SER A  87
ASN A 190
ASP A  84
ASP A  81
LYS A 149
 None
 1.33A 6dwnB-4ryeA:
undetectable		 6dwnB-4ryeA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wi0 CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B
CELLULOSOMAL
SCAFFOLDIN

(Acetivibrio
cellulolyticus;
Acetivibrio
cellulolyticus) 		PF00963
(Cohesin)
PF13620
(CarboxypepD_reg) 		5 SER A  94
PHE B 144
ASN A  90
ASP B 169
ILE A  77
 None
None
None
CA  B 202 (-2.2A)
None
 1.50A 6dwnB-4wi0A:
undetectable		 6dwnB-4wi0A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c16 MYOTUBULARIN-RELATED
PROTEIN 1

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		5 ILE A 565
SER A 560
LEU A 526
PHE A 466
PHE A 501
 None
 1.44A 6dwnB-5c16A:
undetectable		 6dwnB-5c16A:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2c FORM II RUBISCO

(Gallionella) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 ILE A 164
SER A 368
LEU A 169
ASP A 263
ILE A 366
 KCX  A 191 ( 4.1A)
KCX  A 191 ( 4.1A)
None
None
None
 1.23A 6dwnB-5c2cA:
undetectable		 6dwnB-5c2cA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl7 PORIN

(Acinetobacter
baumannii) 		PF03573
(OprD) 		5 ILE A 170
SER A 286
ASN A 380
PHE A 388
ASN A 171
 None
 1.27A 6dwnB-5dl7A:
undetectable		 6dwnB-5dl7A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edv E3 UBIQUITIN-PROTEIN
LIGASE RNF31

(Homo sapiens) 		PF01485
(IBR) 		5 ILE A 739
PHE A 762
LEU A 769
PHE A 730
ASP A 741
 None
 1.40A 6dwnB-5edvA:
undetectable		 6dwnB-5edvA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f3q PUTATIVE
UNCHARACTERIZED
PROTEIN

(Entamoeba
histolytica) 		no annotation 5 ILE A  21
SER A 187
LEU A 101
PHE A 177
ASP A 146
 None
None
None
None
SO4  A 201 ( 4.4A)
 1.16A 6dwnB-5f3qA:
undetectable		 6dwnB-5f3qA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 PHE A 710
LEU A 735
ASN A 732
PHE A 729
ILE A 642
 None
 1.35A 6dwnB-5gr8A:
undetectable		 6dwnB-5gr8A:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgc SERPIN

(Taeniopygia
guttata) 		PF00079
(Serpin) 		5 ASN A  35
PHE A  38
PHE A  87
PHE A 101
ILE A 304
 None
 1.34A 6dwnB-5hgcA:
undetectable		 6dwnB-5hgcA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxs SODIUM,CALCIUM
EXCHANGER

(Methanocaldococcus
jannaschii) 		PF01699
(Na_Ca_ex) 		5 ILE A 234
SER A 268
LEU A 139
ASP A 240
ILE A  82
 None
None
None
SR  A 401 ( 4.7A)
None
 1.29A 6dwnB-5hxsA:
undetectable		 6dwnB-5hxsA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC) 		5 ILE A 998
SER A 969
ASP A 623
ILE A1007
LYS A 631
 None
 1.28A 6dwnB-5hzrA:
undetectable		 6dwnB-5hzrA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE GAMMA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		5 ILE B  72
SER B 503
LEU B  67
ASP B  14
PHE B  48
 None
 1.35A 6dwnB-5l9wB:
undetectable		 6dwnB-5l9wB:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300

(Homo sapiens) 		PF00439
(Bromodomain)
PF06001
(DUF902)
PF08214
(HAT_KAT11) 		5 ILE A1417
PHE A1374
PHE A1448
ASP A1399
ILE A1395
 None
None
None
COO  A1705 (-4.2A)
None
 1.40A 6dwnB-5lkzA:
undetectable		 6dwnB-5lkzA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6v ENVELOPE PROTEIN

(Tick-borne
encephalitis
virus) 		no annotation 5 ILE A 358
SER A   1
PHE A  11
ASP A  42
ASP A  10
 None
 1.38A 6dwnB-5o6vA:
undetectable		 6dwnB-5o6vA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7g CREB-BINDING PROTEIN

(Mus musculus) 		PF00439
(Bromodomain)
PF00569
(ZZ)
PF06001
(DUF902)
PF08214
(HAT_KAT11) 		5 ILE A1454
PHE A1411
PHE A1485
ASP A1436
ILE A1432
 None
 1.41A 6dwnB-5u7gA:
undetectable		 6dwnB-5u7gA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb7 BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		no annotation 5 SER A 337
PHE A 441
ASN A 444
ASP A 438
ILE A 292
 None
GOL  A 803 (-4.7A)
GOL  A 803 (-2.9A)
None
None
 1.43A 6dwnB-5xb7A:
undetectable		 6dwnB-5xb7A:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb7 BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		no annotation 5 SER A 337
PHE A 441
LEU A 443
ASN A 444
ILE A 292
 None
GOL  A 803 (-4.7A)
None
GOL  A 803 (-2.9A)
None
 1.40A 6dwnB-5xb7A:
undetectable		 6dwnB-5xb7A:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Neisseria
gonorrhoeae) 		no annotation 5 ILE A  29
PHE A   5
PHE A  47
ASP A  25
ILE A  95
 None
 1.43A 6dwnB-6bacA:
undetectable		 6dwnB-6bacA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpc RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE

(Plasmodium
vivax) 		no annotation 5 ILE A 296
ASN A 428
ASN A 300
ILE A 189
LYS A 394
 None
 1.39A 6dwnB-6bpcA:
undetectable		 6dwnB-6bpcA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9m N-ALPHA-ACETYLTRANSF
ERASE 15, NATA
AUXILIARY SUBUNIT
N-ALPHA-ACETYLTRANSF
ERASE 10

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		5 SER A 121
PHE A 523
ASP A 524
ILE A 125
LYS B  29
 None
 1.39A 6dwnB-6c9mA:
undetectable		 6dwnB-6c9mA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d04 RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE

(Plasmodium
vivax) 		no annotation 5 ILE E 296
ASN E 428
ASN E 300
ILE E 189
LYS E 394
 None
 1.27A 6dwnB-6d04E:
undetectable		 6dwnB-6d04E:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et0 PQSB

(Pseudomonas
aeruginosa) 		no annotation 5 ILE B 178
PHE B 266
LEU B 196
PHE B 263
ASP B 264
 None
 1.45A 6dwnB-6et0B:
undetectable		 6dwnB-6et0B:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czk FLAVODOXIN

(Synechococcus
elongatus) 		PF00258
(Flavodoxin_1) 		4 ASN A  38
GLY A  53
VAL A  31
LEU A  33
 None
 0.71A 6dwnB-1czkA:
undetectable		 6dwnB-1czkA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dab P.69 PERTACTIN

(Bordetella
pertussis) 		PF03212
(Pertactin) 		4 SER A  63
GLY A 125
ALA A 126
VAL A 240
 None
 0.85A 6dwnB-1dabA:
0.0		 6dwnB-1dabA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2p AMINOPEPTIDASE

(Streptomyces
griseus) 		PF04389
(Peptidase_M28) 		4 SER A 102
GLY A  94
ALA A  93
LEU A 253
 None
 0.80A 6dwnB-1f2pA:
0.0		 6dwnB-1f2pA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ih5 AQUAPORIN-1

(Homo sapiens) 		PF00230
(MIP) 		4 ASN A  76
GLY A 219
ALA A 221
LEU A  81
 None
 0.77A 6dwnB-1ih5A:
1.2		 6dwnB-1ih5A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mn6 POLYKETIDE SYNTHASE
IV

(Streptomyces
venezuelae) 		PF00975
(Thioesterase) 		4 PHE A  99
GLY A 150
ALA A 151
VAL A 232
 None
 0.74A 6dwnB-1mn6A:
undetectable		 6dwnB-1mn6A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt4 GLUCOSE-1-PHOSPHATAS
E

(Escherichia
coli) 		PF00328
(His_Phos_2) 		5 SER A  16
GLY A  61
ALA A 106
VAL A  74
LEU A  68
 None
 1.09A 6dwnB-1nt4A:
0.0		 6dwnB-1nt4A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5z FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE

(Thermotoga
maritima) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ASN A 292
GLY A 316
ALA A 317
VAL A 404
 SO4  A 502 (-3.1A)
None
None
None
 0.76A 6dwnB-1o5zA:
0.0		 6dwnB-1o5zA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ope SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE

(Sus scrofa) 		PF01144
(CoA_trans) 		4 SER A  66
ALA A  37
VAL A 203
LEU A 170
 None
 0.71A 6dwnB-1opeA:
undetectable		 6dwnB-1opeA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rp0 THIAZOLE
BIOSYNTHETIC ENZYME

(Arabidopsis
thaliana) 		PF01946
(Thi4) 		4 PHE A  98
GLY A  48
ALA A  47
LEU A 129
 None
AHZ  A 600 (-3.4A)
None
None
 0.72A 6dwnB-1rp0A:
0.0		 6dwnB-1rp0A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 PHE A 586
ALA A 464
VAL A 438
LEU A 442
 None
 0.73A 6dwnB-1u59A:
undetectable		 6dwnB-1u59A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uax RIBONUCLEASE HII

(Pyrococcus
horikoshii) 		PF01351
(RNase_HII) 		4 GLY A  10
ALA A   9
VAL A  65
LEU A  67
 None
 0.81A 6dwnB-1uaxA:
undetectable		 6dwnB-1uaxA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus) 		PF09231
(RDV-p3) 		4 GLY A 388
ALA A 389
VAL A 645
LEU A 641
 None
 0.82A 6dwnB-1uf2A:
undetectable		 6dwnB-1uf2A:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wac P2 PROTEIN

(Pseudomonas
virus phi6) 		PF00680
(RdRP_1) 		4 GLY A 197
ALA A 198
VAL A 389
LEU A 387
 None
 0.85A 6dwnB-1wacA:
undetectable		 6dwnB-1wacA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzh CYTOCHROME C
PEROXIDASE

(Rhodobacter
capsulatus) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		4 GLY A  37
ALA A  38
VAL A  60
LEU A 166
 None
 0.67A 6dwnB-1zzhA:
undetectable		 6dwnB-1zzhA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF03971
(IDH) 		4 SER A 655
ASN A 730
PHE A 729
VAL A  35
 None
 0.81A 6dwnB-2b0tA:
undetectable		 6dwnB-2b0tA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bih NITRATE REDUCTASE
[NADPH]

(Ogataea angusta) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 PHE A  65
GLY A 162
ALA A 161
LEU A  57
 None
 0.81A 6dwnB-2bihA:
undetectable		 6dwnB-2bihA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bjm IGE SPE7 HEAVY CHAIN

(Mus musculus) 		PF07686
(V-set) 		4 GLY H   8
ALA H   9
VAL H  18
LEU H  20
 None
 0.85A 6dwnB-2bjmH:
undetectable		 6dwnB-2bjmH:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cx9 ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A 258
ALA A  79
VAL A  26
LEU A  22
 None
 0.79A 6dwnB-2cx9A:
undetectable		 6dwnB-2cx9A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA

(Escherichia
coli) 		PF03054
(tRNA_Me_trans) 		4 PHE A 206
GLY A  93
ALA A  92
LEU A 214
 C  C  36 ( 4.0A)
None
None
None
 0.81A 6dwnB-2detA:
undetectable		 6dwnB-2detA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4i HYPOTHETICAL PROTEIN
TM0957

(Thermotoga
maritima) 		PF10054
(DUF2291) 		4 PHE A 146
GLY A 139
VAL A 163
LEU A 159
 MLY  A 142 ( 4.3A)
None
MLY  A 164 ( 3.1A)
None
 0.79A 6dwnB-2f4iA:
undetectable		 6dwnB-2f4iA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gup ROK FAMILY PROTEIN

(Streptococcus
pneumoniae) 		PF00480
(ROK) 		4 SER A  74
ASN A 102
VAL A  95
LEU A  97
 None
None
SUC  A 292 (-4.1A)
None
 0.80A 6dwnB-2gupA:
undetectable		 6dwnB-2gupA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB

(Methanocaldococcus
jannaschii) 		PF02492
(cobW) 		4 ASN A 110
ALA A  35
VAL A 102
LEU A 106
 None
 0.76A 6dwnB-2hf8A:
undetectable		 6dwnB-2hf8A:
15.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens) 		PF00067
(p450) 		4 PHE A 253
GLY A 316
ALA A 317
LEU A 497
 None
BHF  A 800 (-3.8A)
HEM  A 900 ( 3.5A)
BHF  A 800 (-4.4A)
 0.35A 6dwnB-2hi4A:
55.8		 6dwnB-2hi4A:
81.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hlw UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1

(Homo sapiens) 		PF00179
(UQ_con) 		4 ASN A 114
GLY A 121
VAL A 143
LEU A 147
 None
 0.84A 6dwnB-2hlwA:
undetectable		 6dwnB-2hlwA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jk0 L-ASPARAGINASE

(Pectobacterium
carotovorum) 		PF00710
(Asparaginase) 		4 SER A 299
PHE A 324
VAL A 211
LEU A 309
 None
 0.81A 6dwnB-2jk0A:
undetectable		 6dwnB-2jk0A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m8h RNA-BINDING PROTEIN
7

(Homo sapiens) 		PF00076
(RRM_1) 		4 GLY A  41
ALA A  40
VAL A  21
LEU A  19
 None
 0.79A 6dwnB-2m8hA:
undetectable		 6dwnB-2m8hA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		4 SER A 359
GLY A 398
VAL A 427
LEU A 409
 None
 0.83A 6dwnB-2oi6A:
undetectable		 6dwnB-2oi6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		4 PHE A 586
ALA A 464
VAL A 438
LEU A 442
 None
 0.70A 6dwnB-2ozoA:
undetectable		 6dwnB-2ozoA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE

(Lactococcus
lactis) 		PF00232
(Glyco_hydro_1) 		4 PHE A   9
GLY A  13
ALA A  14
VAL A 215
 None
 0.80A 6dwnB-2pbgA:
undetectable		 6dwnB-2pbgA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyv XAA-HIS DIPEPTIDASE

(Histophilus
somni) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 SER A 449
GLY A 432
ALA A 431
LEU A 368
 None
SO4  A 503 (-3.3A)
SO4  A 503 (-3.6A)
None
 0.80A 6dwnB-2qyvA:
undetectable		 6dwnB-2qyvA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uun C-PHYCOCYANIN
C-PHYCOCYANIN

(Leptolyngbya
sp.;
Leptolyngbya
sp.) 		PF00502
(Phycobilisome)
PF00502
(Phycobilisome) 		4 SER A 152
GLY A 102
ALA A 101
VAL B  19
 None
 0.81A 6dwnB-2uunA:
undetectable		 6dwnB-2uunA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn1 ALPHA-GALACTOSIDASE

(Lactobacillus
acidophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 SER A 228
GLY A 540
VAL A 519
LEU A 515
 None
 0.70A 6dwnB-2xn1A:
undetectable		 6dwnB-2xn1A:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu2 UPF0271 PROTEIN
PA4511

(Pseudomonas
aeruginosa) 		PF03746
(LamB_YcsF) 		4 ASN A 220
GLY A 192
ALA A 193
LEU A 180
 None
 0.65A 6dwnB-2xu2A:
undetectable		 6dwnB-2xu2A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6i TRANS-2-ENOYL-ACP
REDUCTASE II

(Streptococcus
pneumoniae) 		PF03060
(NMO) 		4 GLY A 169
ALA A 168
VAL A 157
LEU A 153
 FMN  A 401 (-3.3A)
FMN  A 401 ( 3.9A)
None
None
 0.81A 6dwnB-2z6iA:
undetectable		 6dwnB-2z6iA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP C

(Sulfurisphaera
tokodaii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 ASN C 230
GLY C  54
ALA C  53
LEU C  50
 None
 0.81A 6dwnB-3aizC:
undetectable		 6dwnB-3aizC:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dv9 BETA-PHOSPHOGLUCOMUT
ASE

(Bacteroides
vulgatus) 		PF13419
(HAD_2) 		4 GLY A 199
ALA A 198
VAL A 127
LEU A  24
 None
 0.79A 6dwnB-3dv9A:
undetectable		 6dwnB-3dv9A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff1 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Staphylococcus
aureus) 		PF00342
(PGI) 		4 PHE A  59
GLY A 218
ALA A 217
VAL A  78
 None
 0.84A 6dwnB-3ff1A:
undetectable		 6dwnB-3ff1A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g6l CHITINASE

(Clonostachys
rosea) 		PF00704
(Glyco_hydro_18) 		4 ASN A 236
GLY A 283
ALA A 228
VAL A 186
 None
 0.84A 6dwnB-3g6lA:
undetectable		 6dwnB-3g6lA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gux PUTATIVE
ZN-DEPENDENT
EXOPEPTIDASE

(Bacteroides
vulgatus) 		PF04389
(Peptidase_M28) 		4 ASN A 106
GLY A 150
ALA A 151
LEU A  76
 None
 0.73A 6dwnB-3guxA:
undetectable		 6dwnB-3guxA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjv MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Vibrio cholerae) 		PF00698
(Acyl_transf_1) 		4 GLY A  95
ALA A  94
VAL A 274
LEU A 277
 None
 0.78A 6dwnB-3hjvA:
undetectable		 6dwnB-3hjvA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn2 2-DEHYDROPANTOATE
2-REDUCTASE

(Geobacter
metallireducens) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 SER A 128
GLY A   9
ALA A   8
VAL A  56
LEU A  42
 None
 1.35A 6dwnB-3hn2A:
undetectable		 6dwnB-3hn2A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4s HISTIDINE TRIAD
PROTEIN

(Bradyrhizobium
japonicum) 		PF01230
(HIT) 		4 ASN A 115
ALA A 104
VAL A  60
LEU A  71
 None
 0.63A 6dwnB-3i4sA:
undetectable		 6dwnB-3i4sA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		4 PHE 3 654
GLY 3 548
VAL 3 615
LEU 3 351
 None
 0.75A 6dwnB-3i9v3:
undetectable		 6dwnB-3i9v3:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iq0 PUTATIVE RIBOKINASE
II

(Escherichia
coli) 		PF00294
(PfkB) 		4 SER A  56
ASN A 107
GLY A  36
ALA A  37
 None
 0.84A 6dwnB-3iq0A:
undetectable		 6dwnB-3iq0A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7y MS30

(Homo sapiens) 		PF00829
(Ribosomal_L21p) 		5 ASN s 280
GLY s 337
ALA s 340
VAL s  76
LEU s  80
 None
 1.48A 6dwnB-3j7ys:
undetectable		 6dwnB-3j7ys:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kln TRANSCRIPTIONAL
REGULATOR, LUXR
FAMILY

(Vibrio cholerae) 		PF00196
(GerE) 		4 ASN A 205
GLY A 173
ALA A 174
VAL A 190
 None
 0.84A 6dwnB-3klnA:
undetectable		 6dwnB-3klnA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngj DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Entamoeba
histolytica) 		PF01791
(DeoC) 		4 PHE A  66
GLY A 163
ALA A 164
VAL A 182
 None
 0.84A 6dwnB-3ngjA:
undetectable		 6dwnB-3ngjA:
15.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pm0 CYTOCHROME P450 1B1

(Homo sapiens) 		PF00067
(p450) 		6 SER A 127
PHE A 261
GLY A 329
ALA A 330
VAL A 395
LEU A 509
 BHF  A 800 ( 4.6A)
None
BHF  A 800 ( 4.0A)
HEM  A 900 ( 3.4A)
HEM  A 900 (-4.6A)
BHF  A 800 (-4.7A)
 0.55A 6dwnB-3pm0A:
48.1		 6dwnB-3pm0A:
58.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmo UDP-3-O-[3-HYDROXYMY
RISTOYL] GLUCOSAMINE
N-ACYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00132
(Hexapep)
PF04613
(LpxD) 		4 GLY A 178
ALA A 179
VAL A 173
LEU A 157
 None
 0.82A 6dwnB-3pmoA:
undetectable		 6dwnB-3pmoA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm2 PHOSPHOSERINE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00266
(Aminotran_5) 		5 ASN A 199
GLY A 250
ALA A  53
VAL A  69
LEU A 207
 None
 1.26A 6dwnB-3qm2A:
undetectable		 6dwnB-3qm2A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpq C1068 HEAVY CHAIN

(Homo sapiens;
Mus musculus) 		no annotation 4 GLY H   8
ALA H   9
VAL H  18
LEU H  20
 None
 0.80A 6dwnB-3qpqH:
undetectable		 6dwnB-3qpqH:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3quc INORGANIC
PYROPHOSPHATASE

(Bacteroides
thetaiotaomicron) 		PF13419
(HAD_2) 		4 GLY A 184
ALA A 183
VAL A 112
LEU A   9
 None
 0.78A 6dwnB-3qucA:
undetectable		 6dwnB-3qucA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5c LINA

(uncultured
organism) 		no annotation 4 GLY B  55
ALA B  56
VAL B  24
LEU B  64
 None
 0.85A 6dwnB-3s5cB:
undetectable		 6dwnB-3s5cB:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twd BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep) 		4 SER A 359
GLY A 398
VAL A 427
LEU A 409
 None
 0.82A 6dwnB-3twdA:
undetectable		 6dwnB-3twdA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxb UNCHARACTERIZED
PROTEIN

(Gallus gallus) 		PF00106
(adh_short) 		5 ASN A  95
GLY A 247
ALA A 248
VAL A 237
LEU A 206
 None
 1.27A 6dwnB-3wxbA:
undetectable		 6dwnB-3wxbA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zlb PHOSPHOGLYCERATE
KINASE

(Streptococcus
pneumoniae) 		PF00162
(PGK) 		4 GLY A 278
ALA A 277
VAL A 325
LEU A 297
 None
None
ANP  A1401 (-3.1A)
ANP  A1401 ( 4.7A)
 0.72A 6dwnB-3zlbA:
undetectable		 6dwnB-3zlbA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ASN A 417
GLY A 471
ALA A 470
VAL A 478
 None
 0.82A 6dwnB-3zz1A:
undetectable		 6dwnB-3zz1A:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a73 L-LACTATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY A  90
ALA A  91
VAL A 258
LEU A 262
 None
 0.85A 6dwnB-4a73A:
undetectable		 6dwnB-4a73A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASN A 256
GLY A 237
VAL A 191
LEU A 193
 None
 0.67A 6dwnB-4akoA:
undetectable		 6dwnB-4akoA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akv SORTING NEXIN-33

(Homo sapiens) 		PF00787
(PX)
PF10456
(BAR_3_WASP_bdg) 		4 ASN A 481
GLY A 355
ALA A 356
LEU A 488
 None
 0.80A 6dwnB-4akvA:
undetectable		 6dwnB-4akvA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8w GDP-L-FUCOSE
SYNTHASE

(Homo sapiens) 		PF01370
(Epimerase) 		4 ASN A  96
GLY A  14
VAL A  61
LEU A  57
 None
NAP  A 900 (-3.0A)
None
None
 0.74A 6dwnB-4b8wA:
undetectable		 6dwnB-4b8wA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccd GALACTOCEREBROSIDASE

(Mus musculus) 		PF02057
(Glyco_hydro_59)
PF17387
(Glyco_hydro_59M) 		4 SER A 136
GLY A  49
ALA A  50
VAL A  56
 None
 0.84A 6dwnB-4ccdA:
undetectable		 6dwnB-4ccdA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecm GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Bacillus
anthracis) 		PF00483
(NTP_transferase) 		4 ASN A  99
GLY A 128
ALA A 129
VAL A 104
 None
 0.83A 6dwnB-4ecmA:
undetectable		 6dwnB-4ecmA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqb SPERMIDINE/PUTRESCIN
E ABC SUPERFAMILY
ATP BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF13416
(SBP_bac_8) 		4 ASN A 191
GLY A 342
VAL A 202
LEU A 179
 None
 0.69A 6dwnB-4eqbA:
undetectable		 6dwnB-4eqbA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0u ALLOPHYCOCYANIN
ALPHA CHAIN

(Synechococcus
elongatus) 		PF00502
(Phycobilisome) 		4 SER A 121
GLY A 114
VAL A 169
LEU A 173
 None
 0.74A 6dwnB-4f0uA:
undetectable		 6dwnB-4f0uA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASN A  73
GLY A  52
VAL A  26
LEU A  28
 None
 0.83A 6dwnB-4f7kA:
undetectable		 6dwnB-4f7kA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fuu LEUCINE
AMINOPEPTIDASE

(Bacteroides
thetaiotaomicron) 		PF04389
(Peptidase_M28) 		4 ASN A 106
GLY A 150
ALA A 151
LEU A  76
 None
 0.69A 6dwnB-4fuuA:
undetectable		 6dwnB-4fuuA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE

(Saccharomyces
cerevisiae) 		PF07992
(Pyr_redox_2) 		4 ASN A 406
GLY A  64
ALA A  65
VAL A  79
 ASN  A 406 ( 0.6A)
GLY  A  64 (-0.0A)
ALA  A  65 ( 0.0A)
VAL  A  79 ( 0.6A)
 0.85A 6dwnB-4g9kA:
undetectable		 6dwnB-4g9kA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq9 CHIKUNGUNYA VIRUS
NEUTRALIZING
ANTIBODY 9.8B FAB
FRAGMENT HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H   8
ALA H   9
VAL H  18
LEU H  20
 None
 0.84A 6dwnB-4gq9H:
undetectable		 6dwnB-4gq9H:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gs3 SINGLE-STRANDED
DNA-BINDING PROTEIN

(Caldanaerobacter
subterraneus) 		PF00436
(SSB) 		4 ASN A  34
GLY A  73
VAL A  39
LEU A  37
 None
 0.83A 6dwnB-4gs3A:
undetectable		 6dwnB-4gs3A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2

(Streptococcus
pneumoniae) 		PF12849
(PBP_like_2) 		4 SER A 193
PHE A 165
GLY A  47
VAL A  83
 None
None
CIT  A 302 (-3.2A)
None
 0.83A 6dwnB-4h1xA:
undetectable		 6dwnB-4h1xA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hds ARSA

(Sporomusa ovata) 		PF02277
(DBI_PRT) 		4 SER A 184
GLY A 246
ALA A 249
VAL A 262
 None
 0.78A 6dwnB-4hdsA:
undetectable		 6dwnB-4hdsA:
12.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		7 SER A 116
ASN A 223
PHE A 251
GLY A 316
ALA A 317
VAL A 382
LEU A 496
 BHF  A 602 (-3.2A)
None
None
BHF  A 602 (-3.5A)
BHF  A 602 ( 3.4A)
HEM  A 601 (-4.9A)
None
 0.38A 6dwnB-4i8vA:
61.1		 6dwnB-4i8vA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irx SUGAR ABC
TRANSPORTER,
PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Caulobacter
vibrioides) 		PF13407
(Peripla_BP_4) 		4 ASN A 168
ALA A 274
VAL A 226
LEU A 228
 INS  A 401 (-3.8A)
None
None
None
 0.75A 6dwnB-4irxA:
undetectable		 6dwnB-4irxA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3o OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF00577
(Usher)
PF13953
(PapC_C)
PF13954
(PapC_N) 		4 ASN D 670
GLY D 691
VAL D 676
LEU D 702
 None
 0.71A 6dwnB-4j3oD:
undetectable		 6dwnB-4j3oD:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1

(Staphylococcus
aureus) 		PF13614
(AAA_31) 		4 GLY A1125
ALA A1124
VAL A1075
LEU A1121
 None
 0.79A 6dwnB-4jlvA:
undetectable		 6dwnB-4jlvA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k02 1,4-DIHYDROXY-2-NAPH
THOYL-COA
THIOESTERASE

(Arabidopsis
thaliana) 		PF03061
(4HBT) 		4 ASN A  81
GLY A  50
VAL A  92
LEU A 112
 None
 0.82A 6dwnB-4k02A:
undetectable		 6dwnB-4k02A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A

(Pseudomonas
aeruginosa) 		PF06026
(Rib_5-P_isom_A) 		4 GLY A  52
ALA A  53
VAL A 110
LEU A  80
 None
 0.81A 6dwnB-4x84A:
undetectable		 6dwnB-4x84A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE

(Bacillus cereus) 		PF05547
(Peptidase_M6) 		5 SER A 334
PHE A 377
GLY A 317
ALA A 316
LEU A 170
 None
 1.42A 6dwnB-4yu5A:
undetectable		 6dwnB-4yu5A:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zn2 PSLG

(Pseudomonas
aeruginosa) 		PF00150
(Cellulase) 		4 ASN A 261
GLY A 205
ALA A 204
VAL A 227
 None
 0.77A 6dwnB-4zn2A:
undetectable		 6dwnB-4zn2A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
FAD-BINDING SUBUNIT

(Sulfurisphaera
tokodaii) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 ASN B 248
GLY B 221
ALA B 222
VAL B 191
LEU B 209
 None
 1.48A 6dwnB-4zohB:
undetectable		 6dwnB-4zohB:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)

(Bdellovibrio
bacteriovorus) 		PF06963
(FPN1) 		4 SER A 109
PHE A  39
GLY A 105
ALA A 104
 None
OLC  A 503 (-4.2A)
None
OLC  A 509 (-3.6A)
 0.74A 6dwnB-5aynA:
undetectable		 6dwnB-5aynA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2d HN PROTEIN

(Mumps
rubulavirus) 		PF00423
(HN) 		4 ASN A 391
GLY A 299
VAL A 396
LEU A 394
 None
 0.75A 6dwnB-5b2dA:
undetectable		 6dwnB-5b2dA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck7 ADP-DEPENDENT
GLUCOKINASE

(Mus musculus) 		PF04587
(ADP_PFK_GK) 		4 SER A 320
GLY A 486
ALA A 401
VAL A 451
 None
 0.78A 6dwnB-5ck7A:
undetectable		 6dwnB-5ck7A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eoc FAB FRAGMENT (HEAVY
CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H   8
ALA H   9
VAL H  18
LEU H  20
 None
 0.74A 6dwnB-5eocH:
undetectable		 6dwnB-5eocH:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hha PVDO

(Pseudomonas
aeruginosa) 		PF03781
(FGE-sulfatase) 		4 GLY A 162
ALA A 161
VAL A  41
LEU A  43
 None
 0.81A 6dwnB-5hhaA:
undetectable		 6dwnB-5hhaA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ho9 EXTRACELLULAR
ARABINANASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 SER A 541
GLY A 544
ALA A 531
VAL A 452
 None
 0.68A 6dwnB-5ho9A:
undetectable		 6dwnB-5ho9A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hw3 BETA-LACTAMASE

(Burkholderia
vietnamiensis) 		PF13354
(Beta-lactamase2) 		4 SER A 163
GLY A 144
ALA A 143
VAL A  95
 None
None
None
SO4  A 306 ( 3.7A)
 0.84A 6dwnB-5hw3A:
undetectable		 6dwnB-5hw3A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m31 APPR-1-P PROCESSING
DOMAIN PROTEIN

(Thermus
aquaticus) 		PF01661
(Macro) 		4 ASN A  19
GLY A  95
VAL A 144
LEU A 113
 None
 0.83A 6dwnB-5m31A:
undetectable		 6dwnB-5m31A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0g PRECORRIN-8X
METHYLMUTASE

(Rhodobacter
capsulatus) 		no annotation 4 GLY A 129
ALA A 130
VAL A 201
LEU A  67
 None
 0.82A 6dwnB-5n0gA:
undetectable		 6dwnB-5n0gA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4

(Homo sapiens) 		no annotation 4 ASN A 378
GLY A 311
VAL A 345
LEU A 341
 None
EDO  A 601 ( 3.8A)
None
None
 0.69A 6dwnB-5nqaA:
undetectable		 6dwnB-5nqaA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4

(Homo sapiens) 		no annotation 4 ASN A 378
GLY A 312
VAL A 345
LEU A 341
 None
EDO  A 612 ( 3.2A)
None
None
 0.73A 6dwnB-5nqaA:
undetectable		 6dwnB-5nqaA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ns8 -

(-) 		no annotation 4 ASN A 384
GLY A 391
VAL A 336
LEU A 333
 None
 0.77A 6dwnB-5ns8A:
undetectable		 6dwnB-5ns8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ook PHYCOCYANIN, ALPHA
SUBUNIT
PHYCOCYANIN, BETA
SUBUNIT

(Acaryochloris
marina;
Acaryochloris
marina) 		no annotation
no annotation 		4 SER A 164
GLY A 102
ALA A 101
VAL B  19
 PEG  A 204 (-3.5A)
None
None
None
 0.85A 6dwnB-5ookA:
undetectable		 6dwnB-5ookA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE

(Azospirillum
brasilense) 		no annotation 4 GLY A 127
ALA A 128
VAL A 135
LEU A  68
 ADP  A 301 (-3.0A)
None
None
None
 0.77A 6dwnB-5ovoA:
undetectable		 6dwnB-5ovoA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y50 PROTEIN
DETOXIFICATION 14

(Arabidopsis
thaliana) 		no annotation 4 GLY A 207
ALA A 208
VAL A  70
LEU A 153
 None
 0.84A 6dwnB-5y50A:
2.0		 6dwnB-5y50A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bn2 ACETYL-COA
ACETYLTRANSFERASE

(Elizabethkingia
anophelis) 		no annotation 4 ASN A 117
GLY A 141
VAL A  87
LEU A 350
 None
None
SCY  A  88 ( 2.8A)
SCY  A  88 ( 3.9A)
 0.85A 6dwnB-6bn2A:
undetectable		 6dwnB-6bn2A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ci7 YCAO

(Methanopyrus
kandleri) 		no annotation 5 SER A 171
GLY A 237
ALA A 245
VAL A 187
LEU A 185
 None
 1.22A 6dwnB-6ci7A:
undetectable		 6dwnB-6ci7A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejf -

(-) 		no annotation 4 GLY G 403
ALA G 404
VAL G 444
LEU G 448
 None
 0.65A 6dwnB-6ejfG:
undetectable		 6dwnB-6ejfG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwh IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Acanthamoeba
castellanii) 		no annotation 5 PHE A 169
GLY A  77
ALA A 147
VAL A 180
LEU A 176
 None
 1.35A 6dwnB-6fwhA:
undetectable		 6dwnB-6fwhA:
undetectable