SIMILAR PATTERNS OF AMINO ACIDS FOR 6DWN_A_AQ4A602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a99 PUTRESCINE-BINDING
PROTEIN

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		4 ILE A 140
SER A 267
ALA A 155
LEU A 172
 None
 1.04A 6dwnA-1a99A:
0.0		 6dwnA-1a99A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf5 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		4 ILE A 647
SER A 708
ALA A 611
LEU A 569
 None
 0.92A 6dwnA-1bf5A:
0.0		 6dwnA-1bf5A:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bix AP ENDONUCLEASE 1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 ILE A  91
SER A 135
LEU A 316
LYS A  58
 None
 0.99A 6dwnA-1bixA:
0.0		 6dwnA-1bixA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bsg BETA LACTAMASE

(Streptomyces
albus) 		PF13354
(Beta-lactamase2) 		4 ILE A 127
SER A 126
ALA A  79
LEU A 193
 None
 0.98A 6dwnA-1bsgA:
0.0		 6dwnA-1bsgA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci7 PROTEIN (THYMIDYLATE
SYNTHASE)

(Pneumocystis
carinii) 		PF00303
(Thymidylat_synt) 		4 ILE A  99
SER A  98
ALA A  89
LEU A 109
 None
 0.96A 6dwnA-1ci7A:
0.0		 6dwnA-1ci7A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE

(Methylobacterium
extorquens) 		PF09176
(Mpt_N) 		4 ILE A 215
SER A 214
ALA A 186
LEU A 204
 None
 1.03A 6dwnA-1luaA:
0.0		 6dwnA-1luaA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4s ASPARTATE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		4 ILE A 226
SER A 248
ALA A 165
LEU A 187
 None
 1.01A 6dwnA-1o4sA:
0.0		 6dwnA-1o4sA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX

(Helicobacter
pylori) 		PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 ILE A 213
SER A 173
ALA A 240
LEU A 330
 None
 1.04A 6dwnA-1um8A:
undetectable		 6dwnA-1um8A:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xt0 GUANINE NUCLEOTIDE
EXCHANGE PROTEIN

(Legionella
pneumophila) 		PF01369
(Sec7) 		4 ILE B  24
ALA B  57
LEU B  62
LYS B 106
 None
 1.05A 6dwnA-1xt0B:
0.3		 6dwnA-1xt0B:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvx YFUA

(Yersinia
enterocolitica) 		PF13343
(SBP_bac_6) 		4 ILE A 124
SER A 123
ALA A 160
LEU A 165
 None
 1.02A 6dwnA-1xvxA:
undetectable		 6dwnA-1xvxA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhu HEMOGLOBIN B1A CHAIN

(Riftia
pachyptila) 		PF00042
(Globin) 		4 ILE C 144
SER C 145
ALA C 114
LEU C  75
 None
None
None
HEM  C 160 ( 4.7A)
 0.95A 6dwnA-1yhuC:
undetectable		 6dwnA-1yhuC:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjg SURFACE PROTEIN VSPA

(Borrelia
turicatae) 		PF01441
(Lipoprotein_6) 		4 ILE A  68
SER A  67
ALA A 104
LEU A 137
 None
 0.94A 6dwnA-1yjgA:
undetectable		 6dwnA-1yjgA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrz PROTEIN KINASE C,
IOTA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 ILE A 353
SER A 354
ALA A 346
LEU A 331
 None
 1.06A 6dwnA-1zrzA:
undetectable		 6dwnA-1zrzA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf4 NADPH-CYTOCHROME
P450 REDUCTASE

(Saccharomyces
cerevisiae) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 ILE A 288
SER A 290
ALA A 488
LEU A 499
 None
 0.99A 6dwnA-2bf4A:
undetectable		 6dwnA-2bf4A:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE

(Pseudomonas
syringae group
genomosp. 3) 		PF02615
(Ldh_2) 		4 ILE A 327
SER A 322
ALA A  46
LEU A  22
 None
 1.05A 6dwnA-2cwfA:
undetectable		 6dwnA-2cwfA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ga0 SURFACE PROTEIN VSPA

(Borrelia
turicatae) 		PF01441
(Lipoprotein_6) 		4 ILE A  68
SER A  67
ALA A 104
LEU A 137
 None
 0.94A 6dwnA-2ga0A:
undetectable		 6dwnA-2ga0A:
18.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens) 		PF00067
(p450) 		4 ILE A 117
ALA A 317
LEU A 497
LYS A 500
 None
HEM  A 900 ( 3.5A)
BHF  A 800 (-4.4A)
None
 0.42A 6dwnA-2hi4A:
55.4		 6dwnA-2hi4A:
81.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jhn 3-METHYLADENINE
DNA-GLYCOSYLASE

(Archaeoglobus
fulgidus) 		PF00730
(HhH-GPD) 		4 ILE A 131
SER A 132
ALA A 140
LEU A 180
 None
 1.06A 6dwnA-2jhnA:
undetectable		 6dwnA-2jhnA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfv ISOCITRATE
DEHYDROGENASE [NADP]

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		4 ILE A  72
SER A 307
ALA A 358
LEU A  36
 None
 1.07A 6dwnA-2qfvA:
undetectable		 6dwnA-2qfvA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2reb REC A

(Escherichia
coli) 		PF00154
(RecA) 		4 ILE A  93
SER A 117
ALA A 131
LEU A 178
 None
 1.03A 6dwnA-2rebA:
undetectable		 6dwnA-2rebA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rex RHO-RELATED
GTP-BINDING PROTEIN
RHO6

(Homo sapiens) 		PF00071
(Ras) 		4 ILE B 147
SER B 148
ALA B 156
LEU B 104
 None
None
UNX  B 559 ( 4.1A)
None
 1.02A 6dwnA-2rexB:
undetectable		 6dwnA-2rexB:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0f WSAF

(Geobacillus
stearothermophilus) 		no annotation 4 ILE A 226
ALA A 335
LEU A 312
LYS A 240
 None
 1.06A 6dwnA-2x0fA:
undetectable		 6dwnA-2x0fA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA

(Escherichia
coli) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 ILE A 606
SER A 605
ALA A 554
LEU A 616
 None
 0.96A 6dwnA-2xaxA:
undetectable		 6dwnA-2xaxA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 4 ILE A 434
SER A  11
ALA A 412
LEU A  19
 None
 1.07A 6dwnA-3a0fA:
undetectable		 6dwnA-3a0fA:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bol 5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		4 ILE A 528
SER A 529
ALA A 522
LEU A 544
 None
 1.04A 6dwnA-3bolA:
undetectable		 6dwnA-3bolA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bv4 FRUCTOSE-BISPHOSPHAT
E ALDOLASE A

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		4 ILE A  39
SER A  38
ALA A  31
LEU A  62
 None
None
13P  A3371 ( 4.3A)
None
 0.99A 6dwnA-3bv4A:
undetectable		 6dwnA-3bv4A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ILE A  93
SER A 117
ALA A 131
LEU A 178
 None
 1.03A 6dwnA-3cmtA:
undetectable		 6dwnA-3cmtA:
4.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ILE A1093
SER A1117
ALA A1131
LEU A1178
 None
 1.03A 6dwnA-3cmtA:
undetectable		 6dwnA-3cmtA:
4.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ILE A2093
SER A2117
ALA A2131
LEU A2178
 None
 1.03A 6dwnA-3cmtA:
undetectable		 6dwnA-3cmtA:
4.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ILE A3093
SER A3117
ALA A3131
LEU A3178
 None
 1.03A 6dwnA-3cmtA:
undetectable		 6dwnA-3cmtA:
4.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ILE A4093
SER A4117
ALA A4131
LEU A4178
 None
 1.03A 6dwnA-3cmtA:
undetectable		 6dwnA-3cmtA:
4.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ILE A  93
SER A 117
ALA A 131
LEU A 178
 None
 0.98A 6dwnA-3cmuA:
undetectable		 6dwnA-3cmuA:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ILE A1093
SER A1117
ALA A1131
LEU A1178
 None
 0.97A 6dwnA-3cmuA:
undetectable		 6dwnA-3cmuA:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ILE A2093
SER A2117
ALA A2131
LEU A2178
 None
 0.97A 6dwnA-3cmuA:
undetectable		 6dwnA-3cmuA:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ILE A3093
SER A3117
ALA A3131
LEU A3178
 None
 0.97A 6dwnA-3cmuA:
undetectable		 6dwnA-3cmuA:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ILE A4093
SER A4117
ALA A4131
LEU A4178
 None
 0.97A 6dwnA-3cmuA:
undetectable		 6dwnA-3cmuA:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ILE A5093
SER A5117
ALA A5131
LEU A5178
 None
 0.97A 6dwnA-3cmuA:
undetectable		 6dwnA-3cmuA:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ILE A1093
SER A1117
ALA A1131
LEU A1178
 None
 0.96A 6dwnA-3cmvA:
undetectable		 6dwnA-3cmvA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ILE A2093
SER A2117
ALA A2131
LEU A2178
 None
 1.03A 6dwnA-3cmvA:
undetectable		 6dwnA-3cmvA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3crr TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE

(Pseudomonas
aeruginosa) 		PF01715
(IPPT) 		4 ILE A 252
SER A 251
ALA A 238
LEU A 264
 None
 0.94A 6dwnA-3crrA:
undetectable		 6dwnA-3crrA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4m GLUTAREDOXIN-2,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00462
(Glutaredoxin) 		4 ILE A  69
SER A  70
ALA A  22
LEU A  13
 None
 0.95A 6dwnA-3d4mA:
undetectable		 6dwnA-3d4mA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doo SHIKIMATE
DEHYDROGENASE

(Staphylococcus
epidermidis) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ILE A 180
SER A 207
ALA A 118
LEU A 144
 None
 1.04A 6dwnA-3dooA:
undetectable		 6dwnA-3dooA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e15 GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE

(Plasmodium
vivax) 		PF01182
(Glucosamine_iso) 		4 ILE A 153
SER A 238
ALA A  43
LEU A  84
 None
 1.01A 6dwnA-3e15A:
undetectable		 6dwnA-3e15A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		4 ILE A 291
ALA A 332
LEU A 270
LYS A 490
 None
 0.99A 6dwnA-3g4gA:
undetectable		 6dwnA-3g4gA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B

(Homo sapiens) 		PF00268
(Ribonuc_red_sm) 		4 ILE A 224
SER A 220
ALA A  97
LYS A 168
 None
 0.95A 6dwnA-3hf1A:
undetectable		 6dwnA-3hf1A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A

(Saccharomyces
cerevisiae) 		no annotation 4 ILE C 333
SER C 332
ALA C 361
LEU C 388
 None
 0.83A 6dwnA-3j9uC:
undetectable		 6dwnA-3j9uC:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k25 SLR1438 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF01263
(Aldose_epim) 		4 ILE A 213
SER A 214
ALA A 178
LEU A 253
 None
 1.04A 6dwnA-3k25A:
undetectable		 6dwnA-3k25A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kz3 REPRESSOR PROTEIN CI

(Escherichia
virus Lambda) 		PF01381
(HTH_3) 		4 ILE A  79
SER A  78
ALA A  14
LEU A  64
 None
 1.08A 6dwnA-3kz3A:
undetectable		 6dwnA-3kz3A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS

(Streptomyces
sp. CK4412) 		PF00975
(Thioesterase) 		4 ILE A  61
SER A  89
ALA A 119
LEU A 145
 None
 0.93A 6dwnA-3lcrA:
undetectable		 6dwnA-3lcrA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		4 ILE A 957
SER A 958
ALA A 951
LEU A 944
 None
 1.01A 6dwnA-3lj0A:
undetectable		 6dwnA-3lj0A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndc PRECORRIN-4
C(11)-METHYLTRANSFER
ASE

(Rhodobacter
capsulatus) 		PF00590
(TP_methylase) 		4 ILE A  86
SER A  85
ALA A 114
LEU A 221
 SAH  A 300 (-4.9A)
None
None
SAH  A 300 (-4.4A)
 0.83A 6dwnA-3ndcA:
undetectable		 6dwnA-3ndcA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nk7 23S RRNA
METHYLTRANSFERASE

(Streptomyces
actuosus) 		PF00588
(SpoU_methylase)
PF04705
(TSNR_N) 		4 ILE A 133
SER A 250
ALA A 139
LEU A 171
 None
 1.02A 6dwnA-3nk7A:
undetectable		 6dwnA-3nk7A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		4 ILE A 874
SER A 873
ALA A 373
LEU A 507
 None
 1.08A 6dwnA-3opyA:
undetectable		 6dwnA-3opyA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p24 BFT-3

(Bacteroides
fragilis) 		PF13583
(Reprolysin_4)
PF16376
(fragilysinNterm) 		4 ILE A 304
SER A 336
ALA A 239
LEU A  85
 None
 0.97A 6dwnA-3p24A:
undetectable		 6dwnA-3p24A:
9.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pm0 CYTOCHROME P450 1B1

(Homo sapiens) 		PF00067
(p450) 		4 SER A 127
ALA A 330
LEU A 509
LYS A 512
 BHF  A 800 ( 4.6A)
HEM  A 900 ( 3.4A)
BHF  A 800 (-4.7A)
None
 0.77A 6dwnA-3pm0A:
48.0		 6dwnA-3pm0A:
58.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rio PTSGHI OPERON
ANTITERMINATOR

(Bacillus
subtilis) 		PF00874
(PRD)
PF03123
(CAT_RBD) 		4 ILE A  77
SER A  78
ALA A 108
LEU A 150
 None
 1.03A 6dwnA-3rioA:
undetectable		 6dwnA-3rioA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8m ENOYL-ACP REDUCTASE

(Xanthomonas
oryzae) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		4 ILE A 289
ALA A 278
LEU A 376
LYS A  12
 None
 0.90A 6dwnA-3s8mA:
undetectable		 6dwnA-3s8mA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5i FERROUS IRON
TRANSPORT PROTEIN B

(Gallionella
capsiferriformans) 		PF02421
(FeoB_N) 		4 ILE A 137
SER A 132
ALA A 156
LEU A  82
 None
 1.06A 6dwnA-3w5iA:
undetectable		 6dwnA-3w5iA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo6 MEMBRANE PROTEIN
INSERTASE YIDC 2

(Bacillus
halodurans) 		PF02096
(60KD_IMP) 		4 ILE A  64
SER A  63
ALA A 152
LEU A 240
 None
 1.04A 6dwnA-3wo6A:
undetectable		 6dwnA-3wo6A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 ILE A 701
SER A 344
ALA A 650
LEU A 614
 None
 1.03A 6dwnA-4cakA:
undetectable		 6dwnA-4cakA:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 738
SER A 739
ALA A 747
LEU A 709
 None
 1.07A 6dwnA-4ckrA:
undetectable		 6dwnA-4ckrA:
15.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		5 ILE A 115
SER A 116
ALA A 317
LEU A 496
LYS A 499
 BHF  A 602 (-4.7A)
BHF  A 602 (-3.2A)
BHF  A 602 ( 3.4A)
None
None
 0.43A 6dwnA-4i8vA:
62.1		 6dwnA-4i8vA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4icq AMINOPEPTIDASE PEPS

(Streptococcus
pneumoniae) 		PF02073
(Peptidase_M29) 		4 ILE A 283
SER A 269
ALA A 350
LEU A 307
 None
None
ZN  A 501 ( 4.3A)
None
 1.04A 6dwnA-4icqA:
undetectable		 6dwnA-4icqA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knh NUP192P

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		4 ILE A 873
SER A 872
ALA A 863
LEU A 940
 None
 0.97A 6dwnA-4knhA:
undetectable		 6dwnA-4knhA:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgg MUCONATE LACTONIZING
ENZYME

(Labrenzia
aggregata) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 266
SER A 267
ALA A 108
LEU A 121
 None
 1.01A 6dwnA-4mggA:
undetectable		 6dwnA-4mggA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo sapiens) 		PF01728
(FtsJ) 		4 ILE A 342
SER A 343
ALA A 462
LEU A 385
 None
 0.93A 6dwnA-4n49A:
undetectable		 6dwnA-4n49A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN

(Bordetella
bronchiseptica) 		PF03480
(DctP) 		4 ILE A  51
SER A  50
ALA A 254
LEU A 248
 None
 0.98A 6dwnA-4nq8A:
undetectable		 6dwnA-4nq8A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okr MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii) 		PF00090
(TSP_1)
PF00092
(VWA) 		4 ILE A  87
SER A  84
ALA A 215
LEU A 252
 None
 1.06A 6dwnA-4okrA:
undetectable		 6dwnA-4okrA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3g SIGNAL RECOGNITION
PARTICLE SUBUNIT
SRP68

(Chaetomium
thermophilum) 		PF16969
(SRP68) 		4 ILE A  59
SER A 125
ALA A 135
LEU A  70
 None
 1.05A 6dwnA-4p3gA:
undetectable		 6dwnA-4p3gA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY

(Shewanella
oneidensis) 		PF07804
(HipA_C)
PF13657
(Couple_hipA) 		4 ILE A  95
SER A 147
ALA A 104
LEU A   9
 None
 1.02A 6dwnA-4pu5A:
undetectable		 6dwnA-4pu5A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmh LP04448P

(Drosophila
melanogaster) 		PF12348
(CLASP_N) 		4 ILE A 888
SER A 889
ALA A 922
LEU A 905
 None
 1.06A 6dwnA-4qmhA:
undetectable		 6dwnA-4qmhA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013) 		PF12697
(Abhydrolase_6) 		4 ILE A 271
SER A 272
ALA A  50
LEU A  54
 None
 0.74A 6dwnA-4rncA:
undetectable		 6dwnA-4rncA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rot ESTERASE A

(Streptococcus
pyogenes) 		PF00756
(Esterase) 		4 ILE A  22
SER A   3
ALA A  60
LEU A 243
 None
 0.94A 6dwnA-4rotA:
undetectable		 6dwnA-4rotA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqv ALGM2

(Sphingomonas
sp.) 		PF00528
(BPD_transp_1) 		4 ILE B 167
SER B 166
ALA B  99
LEU B 186
 None
 1.03A 6dwnA-4tqvB:
undetectable		 6dwnA-4tqvB:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjn NUCLEOCAPSID

(Mammalian
rubulavirus 5) 		PF00973
(Paramyxo_ncap) 		4 ILE A  58
SER A  61
ALA A 129
LEU A 114
 None
 1.06A 6dwnA-4xjnA:
undetectable		 6dwnA-4xjnA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xru RNL

(Capnocytophaga
gingivalis) 		PF16542
(PNKP_ligase) 		4 ILE B  69
SER B 119
ALA B  99
LEU B  75
 None
 0.96A 6dwnA-4xruB:
undetectable		 6dwnA-4xruB:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwx SHC-TRANSFORMING
PROTEIN 1

(Homo sapiens) 		PF00640
(PID) 		4 ILE A 150
SER A 149
ALA A 143
LEU A 124
 None
 1.06A 6dwnA-4xwxA:
undetectable		 6dwnA-4xwxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ab8 GROUP 1 TRUNCATED
HEMOGLOBIN GLBN

(Mycobacterium
tuberculosis) 		PF01152
(Bac_globin) 		4 ILE A  15
SER A  14
ALA A  24
LEU A 102
 None
 1.00A 6dwnA-5ab8A:
undetectable		 6dwnA-5ab8A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 ILE A 794
SER A 310
LEU A 800
LYS A 912
 None
 0.74A 6dwnA-5aw4A:
undetectable		 6dwnA-5aw4A:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ILE A 343
SER A 342
ALA A 242
LEU A  18
 None
 1.07A 6dwnA-5bp1A:
undetectable		 6dwnA-5bp1A:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cek TRIBBLES HOMOLOG 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 307
SER A 308
ALA A 183
LEU A 277
 None
 0.94A 6dwnA-5cekA:
undetectable		 6dwnA-5cekA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		4 ILE A1008
SER A 647
ALA A 885
LEU A 983
 None
 1.03A 6dwnA-5d0fA:
undetectable		 6dwnA-5d0fA:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3m ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2

(Lactobacillus
delbrueckii) 		PF00005
(ABC_tran) 		4 ILE B 167
SER B  88
ALA B 157
LEU B 187
 None
 0.97A 6dwnA-5d3mB:
undetectable		 6dwnA-5d3mB:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 ILE A1192
SER A1193
ALA A1180
LEU A1296
 None
 0.98A 6dwnA-5dotA:
undetectable		 6dwnA-5dotA:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		4 ILE B 873
SER B 872
ALA B 863
LEU B 940
 None
 0.88A 6dwnA-5hb4B:
undetectable		 6dwnA-5hb4B:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hos CELLULASE

(Xanthomonas
citri) 		PF00150
(Cellulase) 		4 ILE A 196
SER A 195
ALA A 150
LEU A 135
 None
 1.08A 6dwnA-5hosA:
undetectable		 6dwnA-5hosA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 ILE A 452
SER A 455
ALA A 506
LEU A 181
 None
 0.97A 6dwnA-5ikrA:
undetectable		 6dwnA-5ikrA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrj PROTEIN RECA

(Herbaspirillum
seropedicae) 		PF00154
(RecA) 		4 ILE A 100
SER A 124
ALA A 138
LEU A 185
 None
 1.03A 6dwnA-5jrjA:
undetectable		 6dwnA-5jrjA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens) 		no annotation 4 ILE A 311
SER A 180
ALA A 121
LEU A 281
 None
 0.92A 6dwnA-5mg5A:
undetectable		 6dwnA-5mg5A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkz UBIQUITIN-CONJUGATIN
G ENZYME E2-21 KDA

(Ogataea angusta) 		no annotation 4 ILE A  26
SER A  24
ALA A  14
LEU A  34
 None
 0.97A 6dwnA-5nkzA:
undetectable		 6dwnA-5nkzA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn7 URACIL-DNA
GLYCOSYLASE

(Human
gammaherpesvirus
8) 		no annotation 4 ILE A 115
SER A 114
ALA A 208
LEU A 185
 None
 0.95A 6dwnA-5nn7A:
undetectable		 6dwnA-5nn7A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		4 ILE A1591
SER A1590
ALA A1565
LEU A1616
 None
 0.92A 6dwnA-5t8vA:
undetectable		 6dwnA-5t8vA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uao TRYPTOPHANE-5-HALOGE
NASE

(Microbispora
sp. ATCC
PTA-5024) 		PF04820
(Trp_halogenase) 		4 ILE A 403
SER A 402
ALA A 455
LEU A 441
 None
 0.72A 6dwnA-5uaoA:
undetectable		 6dwnA-5uaoA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvg SPHINGOMYELIN
PHOSPHODIESTERASE
3,SPHINGOMYELIN
PHOSPHODIESTERASE 3

(Homo sapiens) 		no annotation 4 ILE A 630
SER A 350
ALA A 162
LEU A 360
 None
 0.91A 6dwnA-5uvgA:
undetectable		 6dwnA-5uvgA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		no annotation 4 ILE A 125
ALA A 166
LEU A 104
LYS A 324
 None
 0.96A 6dwnA-5wh6A:
undetectable		 6dwnA-5wh6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfm ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 ILE A 314
SER A 313
ALA A 334
LEU A 365
 None
 0.94A 6dwnA-5xfmA:
undetectable		 6dwnA-5xfmA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjj MULTI DRUG EFFLUX
TRANSPORTER

(Camelina sativa) 		PF01554
(MatE) 		4 ILE A 122
SER A 123
ALA A 161
LEU A  84
 None
 1.02A 6dwnA-5xjjA:
undetectable		 6dwnA-5xjjA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ams BETA SLIDING CLAMP

(Pseudomonas
aeruginosa) 		no annotation 4 ILE A 224
SER A 235
ALA A 205
LEU A 135
 None
 1.07A 6dwnA-6amsA:
undetectable		 6dwnA-6amsA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cza -

(-) 		no annotation 4 ILE A 387
SER A 388
ALA A 694
LEU A 672
 None
 0.93A 6dwnA-6czaA:
undetectable		 6dwnA-6czaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d9h CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1

(Homo sapiens) 		no annotation 4 ILE R 239
SER R 235
ALA R 289
LEU R  51
 None
 1.07A 6dwnA-6d9hR:
undetectable		 6dwnA-6d9hR:
21.65