SIMILAR PATTERNS OF AMINO ACIDS FOR 6DWN_A_AQ4A602_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)

(Ruminiclostridium
thermocellum) 		PF01270
(Glyco_hydro_8) 		5 SER A 272
ASN A 330
ASP A 274
GLY A 320
ASP A 319
 None
 1.10A 6dwnA-1cemA:
0.0		 6dwnA-1cemA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ASN A 205
ASN A 239
ASN A 310
ASP A 356
ASP A 362
 None
 1.37A 6dwnA-1e8cA:
0.0		 6dwnA-1e8cA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6f PLACENTAL LACTOGEN

(Ovis aries) 		PF00103
(Hormone_1) 		5 LEU A  18
PHE A  22
PHE A  83
ASP A  79
ILE A  75
 None
 1.31A 6dwnA-1f6fA:
undetectable		 6dwnA-1f6fA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTM, FLAVOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 ASN C  55
LEU C  31
ASP C 115
GLY C 110
ILE C 170
 None
None
FAD  C1922 (-2.9A)
FAD  C1922 (-3.7A)
None
 1.16A 6dwnA-1ffvC:
undetectable		 6dwnA-1ffvC:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTM, FLAVOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 PHE C 153
LEU C 224
ASP C 115
GLY C 119
ILE C 170
 None
None
FAD  C1922 (-2.9A)
None
None
 1.34A 6dwnA-1ffvC:
undetectable		 6dwnA-1ffvC:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g3n V-CYCLIN

(Human
gammaherpesvirus
8) 		PF00134
(Cyclin_N)
PF09080
(K-cyclin_vir_C) 		5 SER C 245
ASN C  77
LEU C 150
GLY C 190
ASP C  80
 None
 1.38A 6dwnA-1g3nC:
0.0		 6dwnA-1g3nC:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h14 ENDO-1,4-BETA-XYLANA
SE

(Pseudoalteromonas
haloplanktis) 		PF01270
(Glyco_hydro_8) 		5 ASN A 402
ASN A 401
LEU A 154
ASN A 155
GLY A 161
 None
 1.30A 6dwnA-1h14A:
undetectable		 6dwnA-1h14A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkw DIAMINOPIMELATE
DECARBOXYLASE

(Mycobacterium
tuberculosis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 PHE A  43
LEU A 433
PHE A  74
GLY A 403
ILE A 381
 None
 1.33A 6dwnA-1hkwA:
undetectable		 6dwnA-1hkwA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxh 3BETA/17BETA-HYDROXY
STEROID
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13561
(adh_short_C2) 		5 ASN A  86
ASN A 135
LEU A  84
GLY A  13
ILE A 186
 None
 1.31A 6dwnA-1hxhA:
undetectable		 6dwnA-1hxhA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC

(Canis lupus) 		PF00561
(Abhydrolase_1) 		5 SER A  99
PHE A  62
LEU A 139
ASP A 130
PHE A 163
 None
 1.15A 6dwnA-1k8qA:
0.0		 6dwnA-1k8qA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Geobacillus
stearothermophilus) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		5 LEU A 295
ASN A 259
PHE A 260
ASP A 154
GLY A 121
 None
None
None
2PG  A 801 (-2.6A)
None
 1.06A 6dwnA-1o99A:
0.0		 6dwnA-1o99A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oht CG14704 PROTEIN

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		5 SER A 108
ASN A 179
PHE A 175
GLY A 151
PHE A 166
 None
TLA  A1188 (-3.2A)
None
None
None
 1.35A 6dwnA-1ohtA:
undetectable		 6dwnA-1ohtA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2j PEPTIDOGLYCAN
RECOGNITION PROTEIN
SA CG11709-PA

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		5 SER A  49
LEU A 163
PHE A 111
ASP A  83
ASP A 122
 None
 1.36A 6dwnA-1s2jA:
undetectable		 6dwnA-1s2jA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Synechococcus
elongatus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 SER A  44
LEU A 300
ASP A  46
ASP A 382
ILE A  41
 None
None
None
None
HDF  A5486 (-3.9A)
 1.19A 6dwnA-1tezA:
undetectable		 6dwnA-1tezA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wao SERINE/THREONINE
PROTEIN PHOSPHATASE
5

(Homo sapiens) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5) 		5 SER 1 403
ASN 1 269
LEU 1 300
ASP 1 383
GLY 1 354
 None
 1.17A 6dwnA-1wao1:
undetectable		 6dwnA-1wao1:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we0 ALKYL HYDROPEROXIDE
REDUCTASE C

(Amphibacillus
xylanus) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		5 LEU A   2
PHE A 123
GLY A 121
ASP A 119
ILE A 141
 None
 1.35A 6dwnA-1we0A:
undetectable		 6dwnA-1we0A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB

(Mycobacterium
tuberculosis) 		PF13350
(Y_phosphatase3) 		5 ASN A 193
LEU A 190
GLY A 230
ASP A 229
ILE A 203
 None
 1.24A 6dwnA-1ywfA:
undetectable		 6dwnA-1ywfA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z34 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Trichomonas
vaginalis) 		PF01048
(PNP_UDP_1) 		5 SER A 182
LEU A 229
GLY A  89
PHE A 221
ILE A  69
 None
 1.15A 6dwnA-1z34A:
undetectable		 6dwnA-1z34A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 SER A 431
ASN A 260
ASN A 257
ASP A 520
GLY A 518
 None
 1.20A 6dwnA-1z8lA:
undetectable		 6dwnA-1z8lA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf6 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF13088
(BNR_2) 		5 ASN A 448
ASN A 432
ASN A 417
GLY A 361
PHE A 362
 None
 1.30A 6dwnA-2bf6A:
undetectable		 6dwnA-2bf6A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d99 GENERAL
TRANSCRIPTION FACTOR
II-I REPEAT
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF02946
(GTF2I) 		5 SER A  73
PHE A  78
LEU A  80
ASP A  17
ILE A  69
 None
 1.37A 6dwnA-2d99A:
undetectable		 6dwnA-2d99A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dy3 ALANINE RACEMASE

(Corynebacterium
glutamicum) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 SER A 288
ASP A 295
GLY A 293
ASP A 292
ILE A 309
 None
 1.25A 6dwnA-2dy3A:
undetectable		 6dwnA-2dy3A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6t UNCHARACTERIZED
PROTEIN, HOMOLOG
HI1244 FROM
HAEMOPHILUS
INFLUENZAE

(Clostridium
acetobutylicum) 		PF08942
(DUF1919) 		5 PHE A  99
PHE A  95
GLY A  91
PHE A  66
ILE A 108
 None
 1.35A 6dwnA-2g6tA:
undetectable		 6dwnA-2g6tA:
12.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens) 		PF00067
(p450) 		6 PHE A 226
ASN A 257
ASP A 313
GLY A 316
ASP A 320
ILE A 386
 BHF  A 800 (-3.6A)
None
BHF  A 800 (-3.9A)
BHF  A 800 (-3.8A)
BHF  A 800 (-4.0A)
HEM  A 900 (-4.0A)
 0.55A 6dwnA-2hi4A:
55.4		 6dwnA-2hi4A:
81.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2izv SUPPRESSOR OF
CYTOKINE SIGNALING 4

(Homo sapiens) 		PF00017
(SH2)
PF07525
(SOCS_box) 		5 SER A 323
ASN A 282
LEU A 278
GLY A 289
PHE A 387
 None
None
None
CL  A1432 ( 4.0A)
CL  A1432 ( 4.6A)
 1.35A 6dwnA-2izvA:
undetectable		 6dwnA-2izvA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jqj DNA DAMAGE RESPONSE
PROTEIN KINASE DUN1

(Saccharomyces
cerevisiae) 		PF00498
(FHA) 		5 SER A 101
ASN A 108
LEU A 119
PHE A  80
PHE A 133
 None
 1.37A 6dwnA-2jqjA:
undetectable		 6dwnA-2jqjA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jr0 N UTILIZATION
SUBSTANCE PROTEIN B
HOMOLOG

(Aquifex
aeolicus) 		PF01029
(NusB) 		5 SER A  73
PHE A 122
ASP A  75
GLY A  78
ILE A  65
 None
 1.34A 6dwnA-2jr0A:
undetectable		 6dwnA-2jr0A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qde MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Aromatoleum
aromaticum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 SER A 302
ASP A  49
GLY A  33
ASP A  32
ILE A 332
 None
 1.32A 6dwnA-2qdeA:
undetectable		 6dwnA-2qdeA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rag DIPEPTIDASE

(Caulobacter
vibrioides) 		PF01244
(Peptidase_M19) 		5 LEU A  82
ASP A  51
GLY A  92
ASP A  91
ILE A 379
 None
 1.08A 6dwnA-2ragA:
undetectable		 6dwnA-2ragA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE

(Dictyostelium
discoideum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		5 SER A 191
ASN A  22
LEU A 129
GLY A 173
ILE A 144
 None
None
None
FAD  A1587 (-3.4A)
None
 1.31A 6dwnA-2uuuA:
undetectable		 6dwnA-2uuuA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		5 ASN A 474
PHE A 593
GLY A 576
PHE A 577
ILE A 567
 None
 1.37A 6dwnA-2v26A:
undetectable		 6dwnA-2v26A:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9t ROUNDABOUT HOMOLOG 1
SLIT HOMOLOG 2
PROTEIN N-PRODUCT

(Homo sapiens;
Homo sapiens) 		PF13927
(Ig_3)
PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		5 SER A  75
ASN B 334
ASN B 358
LEU B 331
GLY B 288
 None
 1.30A 6dwnA-2v9tA:
undetectable		 6dwnA-2v9tA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK) 		PF00202
(Aminotran_3) 		5 ASN A 351
PHE A 348
ASP A 423
GLY A 425
PHE A  85
 None
 1.35A 6dwnA-2ykyA:
undetectable		 6dwnA-2ykyA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn9 POTASSIUM-TRANSPORTI
NG ATPASE ALPHA
CHAIN 1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF09040
(H-K_ATPase_N)
PF13246
(Cation_ATPase) 		5 SER A 169
LEU A 759
ASP A 749
ASP A 730
ILE A 166
 None
 1.38A 6dwnA-2yn9A:
undetectable		 6dwnA-2yn9A:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3d PUTATIVE MORPHINE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		5 LEU A 196
ASP A  49
GLY A  21
PHE A  20
ILE A 165
 CA  A 281 (-4.2A)
None
None
None
None
 1.12A 6dwnA-3b3dA:
undetectable		 6dwnA-3b3dA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfh MANDELATE RACEMASE

(Vibrionales
bacterium
SWAT-3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASN A 262
ASN A 263
PHE A 261
ASP A 234
ILE A 276
 None
 1.32A 6dwnA-3dfhA:
undetectable		 6dwnA-3dfhA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e38 TWO-DOMAIN PROTEIN
CONTAINING PREDICTED
PHP-LIKE
METAL-DEPENDENT
PHOSPHOESTERASE

(Bacteroides
vulgatus) 		PF16392
(DUF5001) 		5 PHE A 154
ASN A 156
ASP A  42
GLY A 211
ILE A 109
 None
 1.07A 6dwnA-3e38A:
undetectable		 6dwnA-3e38A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eza PHOSPHOTRANSFERASE
SYSTEM, ENZYME I

(Escherichia
coli) 		PF00391
(PEP-utilizers)
PF05524
(PEP-utilisers_N) 		5 SER A 166
LEU A 142
ASP A 132
GLY A 134
ILE A  57
 None
 1.14A 6dwnA-3ezaA:
undetectable		 6dwnA-3ezaA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fed GLUTAMATE
CARBOXYPEPTIDASE III

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 SER A 421
ASN A 250
ASN A 247
ASP A 510
GLY A 508
 None
None
BIX  A   1 (-3.2A)
None
BIX  A   1 (-3.4A)
 1.17A 6dwnA-3fedA:
undetectable		 6dwnA-3fedA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fky GLUTAMINE SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		5 LEU A 117
PHE A 118
ASP A 213
PHE A 128
ILE A  31
 None
 1.29A 6dwnA-3fkyA:
undetectable		 6dwnA-3fkyA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goz LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN

(Legionella
pneumophila) 		no annotation 5 ASN A 148
ASN A 177
LEU A 145
ASN A 144
GLY A  89
 None
 1.02A 6dwnA-3gozA:
undetectable		 6dwnA-3gozA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5

(Homo sapiens) 		PF00149
(Metallophos)
PF08321
(PPP5) 		5 SER A 403
ASN A 269
LEU A 300
ASP A 383
GLY A 354
 None
 1.22A 6dwnA-3h68A:
undetectable		 6dwnA-3h68A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbn UDP-SUGAR HYDROLASE

(Campylobacter
jejuni) 		no annotation 5 SER A 173
ASP A 168
GLY A 166
PHE A  15
ILE A 188
 None
None
UDP  A 301 (-3.5A)
None
None
 1.04A 6dwnA-3hbnA:
undetectable		 6dwnA-3hbnA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbu SECRETED PROTEASE C

(Dickeya
chrysanthemi) 		PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		5 ASN P  98
PHE P  97
ASN P 135
PHE P  94
ILE P 190
 None
 1.26A 6dwnA-3hbuP:
undetectable		 6dwnA-3hbuP:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm0 PROBABLE
THIOESTERASE

(Bartonella
henselae) 		PF03061
(4HBT) 		5 LEU A  60
ASN A  57
PHE A  71
PHE A 104
ILE A  92
 None
 1.33A 6dwnA-3hm0A:
undetectable		 6dwnA-3hm0A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ioy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Novosphingobium
aromaticivorans) 		PF00106
(adh_short) 		5 SER A 256
ASN A  16
ASN A  92
GLY A 240
ASP A 237
 None
 1.36A 6dwnA-3ioyA:
undetectable		 6dwnA-3ioyA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Thermoanaerobacter
pseudethanolicus) 		PF00724
(Oxidored_FMN) 		5 ASN A  76
ASP A  71
GLY A  33
ASP A  32
ILE A 110
 None
 1.26A 6dwnA-3krzA:
undetectable		 6dwnA-3krzA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvn ESTERASE ESTA

(Pseudomonas
aeruginosa) 		no annotation 5 SER X  14
ASN X 213
LEU X 186
ASP X  13
GLY X 145
 C8E  X 623 (-2.9A)
None
None
C8E  X 623 ( 4.2A)
None
 1.36A 6dwnA-3kvnX:
undetectable		 6dwnA-3kvnX:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m19 VARIABLE LYMPHOCYTE
RECEPTOR A DIVERSITY
REGION

(Petromyzon
marinus) 		PF13855
(LRR_8) 		5 ASN A  68
ASN A  92
LEU A  65
ASN A  64
GLY A  22
 None
 1.10A 6dwnA-3m19A:
undetectable		 6dwnA-3m19A:
15.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pm0 CYTOCHROME P450 1B1

(Homo sapiens) 		PF00067
(p450) 		5 ASN A 228
PHE A 231
PHE A 268
ASP A 326
GLY A 329
 BHF  A 800 (-4.2A)
BHF  A 800 (-3.4A)
BHF  A 800 ( 3.8A)
BHF  A 800 (-3.4A)
BHF  A 800 ( 4.0A)
 1.19A 6dwnA-3pm0A:
48.0		 6dwnA-3pm0A:
58.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pm0 CYTOCHROME P450 1B1

(Homo sapiens) 		PF00067
(p450) 		7 PHE A 231
ASN A 265
PHE A 268
ASP A 326
GLY A 329
ASP A 333
ILE A 399
 BHF  A 800 (-3.4A)
None
BHF  A 800 ( 3.8A)
BHF  A 800 (-3.4A)
BHF  A 800 ( 4.0A)
BHF  A 800 ( 4.1A)
HEM  A 900 (-4.0A)
 0.62A 6dwnA-3pm0A:
48.0		 6dwnA-3pm0A:
58.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rw7 NUCLEAR RNA EXPORT
FACTOR 1

(Homo sapiens) 		PF09162
(Tap-RNA_bind) 		5 ASN A 301
ASN A 325
LEU A 298
ASN A 297
GLY A 231
 None
 1.24A 6dwnA-3rw7A:
undetectable		 6dwnA-3rw7A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sll PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		5 SER A 191
ASN A  25
ASN A  19
ASP A 132
GLY A 111
 None
 1.27A 6dwnA-3sllA:
undetectable		 6dwnA-3sllA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tji MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Enterobacter
sp. 638) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASN A 260
ASN A 261
PHE A 259
ASP A 232
ILE A 274
 None
None
None
MG  A 601 ( 4.8A)
None
 1.38A 6dwnA-3tjiA:
undetectable		 6dwnA-3tjiA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uqz DNA PROCESSING
PROTEIN DPRA

(Streptococcus
pneumoniae) 		PF02481
(DNA_processg_A) 		5 SER A 140
LEU A 255
ASP A 147
GLY A 145
ILE A 138
 None
 1.21A 6dwnA-3uqzA:
undetectable		 6dwnA-3uqzA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C

(Homo sapiens) 		PF00560
(LRR_1)
PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 ASN A 277
ASN A 301
LEU A 274
ASN A 273
GLY A 228
 None
 1.18A 6dwnA-3zyjA:
undetectable		 6dwnA-3zyjA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
NETRIN-G1

(Homo sapiens;
Homo sapiens) 		PF00560
(LRR_1)
PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8)
PF00053
(Laminin_EGF)
PF00055
(Laminin_N) 		5 SER B 228
ASN A 277
ASN A 301
LEU A 274
GLY A 228
 None
 1.24A 6dwnA-3zyjB:
undetectable		 6dwnA-3zyjB:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 ASN A 289
ASN A 313
LEU A 286
ASN A 285
GLY A 240
 None
 1.18A 6dwnA-3zynA:
undetectable		 6dwnA-3zynA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B

(Mus musculus) 		PF00560
(LRR_1)
PF07679
(I-set)
PF13855
(LRR_8) 		5 ASN A 289
ASN A 313
LEU A 286
ASN A 285
GLY A 240
 None
 1.23A 6dwnA-3zyoA:
undetectable		 6dwnA-3zyoA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7p UDP-GLUCOSE
DEHYDROGENASE

(Sphingomonas
elodea) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 SER A  88
ASN A 212
GLY A 262
PHE A 324
ASP A 330
 None
 1.31A 6dwnA-4a7pA:
undetectable		 6dwnA-4a7pA:
10.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		5 ASN A 222
ASN A 223
LEU A 254
PHE A 258
PHE A 319
 BHF  A 602 ( 3.8A)
None
None
BHF  A 602 ( 3.9A)
BHF  A 602 ( 4.7A)
 1.17A 6dwnA-4i8vA:
62.1		 6dwnA-4i8vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		5 ASN A 223
LEU A 254
ASN A 255
PHE A 258
PHE A 319
 None
None
None
BHF  A 602 ( 3.9A)
BHF  A 602 ( 4.7A)
 1.01A 6dwnA-4i8vA:
62.1		 6dwnA-4i8vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		6 SER A 120
ASN A 222
PHE A 224
ASP A 313
GLY A 316
PHE A 319
 BHF  A 602 ( 4.5A)
BHF  A 602 ( 3.8A)
BHF  A 602 (-3.3A)
BHF  A 602 (-3.7A)
BHF  A 602 (-3.5A)
BHF  A 602 ( 4.7A)
 1.49A 6dwnA-4i8vA:
62.1		 6dwnA-4i8vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		6 SER A 120
PHE A 224
ASP A 313
GLY A 316
PHE A 319
ASP A 320
 BHF  A 602 ( 4.5A)
BHF  A 602 (-3.3A)
BHF  A 602 (-3.7A)
BHF  A 602 (-3.5A)
BHF  A 602 ( 4.7A)
BHF  A 602 (-3.7A)
 1.48A 6dwnA-4i8vA:
62.1		 6dwnA-4i8vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		9 SER A 122
ASN A 222
ASN A 223
PHE A 224
PHE A 258
ASP A 313
GLY A 316
PHE A 319
ILE A 386
 HEM  A 601 (-3.4A)
BHF  A 602 ( 3.8A)
None
BHF  A 602 (-3.3A)
BHF  A 602 ( 3.9A)
BHF  A 602 (-3.7A)
BHF  A 602 (-3.5A)
BHF  A 602 ( 4.7A)
HEM  A 601 (-3.6A)
 0.69A 6dwnA-4i8vA:
62.1		 6dwnA-4i8vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		10 SER A 122
ASN A 223
PHE A 224
ASN A 255
PHE A 258
ASP A 313
GLY A 316
PHE A 319
ASP A 320
ILE A 386
 HEM  A 601 (-3.4A)
None
BHF  A 602 (-3.3A)
None
BHF  A 602 ( 3.9A)
BHF  A 602 (-3.7A)
BHF  A 602 (-3.5A)
BHF  A 602 ( 4.7A)
BHF  A 602 (-3.7A)
HEM  A 601 (-3.6A)
 0.48A 6dwnA-4i8vA:
62.1		 6dwnA-4i8vA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irt UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF15892
(BNR_4) 		5 SER A 367
ASN A 280
ASN A 302
ASP A 363
GLY A 341
 CL  A 502 (-4.3A)
None
None
None
None
 1.19A 6dwnA-4irtA:
undetectable		 6dwnA-4irtA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxf TREHALOSE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 SER A 459
LEU A 389
GLY A 419
ASP A 416
ILE A 434
 None
None
None
GOL  A 704 (-3.5A)
None
 1.38A 6dwnA-4lxfA:
undetectable		 6dwnA-4lxfA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 ASN A 570
ASN A 521
GLY A 613
ASP A 660
ILE A 540
 None
NAG  A 805 ( 4.5A)
None
None
None
 1.25A 6dwnA-4m7eA:
undetectable		 6dwnA-4m7eA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4non FERROUS IRON UPTAKE
TRANSPORTER PROTEIN
B

(Streptococcus
thermophilus) 		PF02421
(FeoB_N) 		5 ASN A   9
LEU A  97
ASN A  84
GLY A  13
ILE A 115
 ASN  A   9 ( 0.6A)
LEU  A  97 ( 0.6A)
ASN  A  84 ( 0.6A)
GLY  A  13 (-0.0A)
ILE  A 115 ( 0.4A)
 1.33A 6dwnA-4nonA:
undetectable		 6dwnA-4nonA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pq8 DESIGNED PROTEIN
OR465

(synthetic
construct) 		PF00560
(LRR_1)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 ASN A 126
ASN A 150
LEU A 123
ASN A 122
GLY A  79
 None
None
None
CL  A 301 (-4.3A)
None
 1.14A 6dwnA-4pq8A:
undetectable		 6dwnA-4pq8A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psj OR464

(synthetic
construct) 		PF12354
(Internalin_N)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 ASN A 126
ASN A 150
LEU A 123
ASN A 122
GLY A  79
 None
 1.09A 6dwnA-4psjA:
undetectable		 6dwnA-4psjA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA

(Eptatretus
burgeri;
Mus musculus) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 ASN A 315
ASN A 340
LEU A 312
ASN A 311
GLY A 266
 None
None
None
NAG  A 505 (-1.9A)
None
 1.10A 6dwnA-4qdhA:
undetectable		 6dwnA-4qdhA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5c LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 ASN A 118
ASN A 142
LEU A 115
ASN A 114
GLY A  71
 None
 1.12A 6dwnA-4r5cA:
undetectable		 6dwnA-4r5cA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5d LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 ASN A 118
ASN A 142
LEU A 115
ASN A 114
GLY A  71
 None
 1.10A 6dwnA-4r5dA:
undetectable		 6dwnA-4r5dA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6g LEUCINE RICH REPEATS
DLRR_K

(synthetic
construct) 		PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 ASN A 118
ASN A 142
LEU A 115
ASN A 114
GLY A  71
 None
 1.13A 6dwnA-4r6gA:
undetectable		 6dwnA-4r6gA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei) 		PF00067
(p450) 		5 ASN A 390
PHE A 395
LEU A 393
PHE A 295
ILE A 244
 SO4  A 506 ( 3.8A)
SO4  A 511 (-4.7A)
None
None
None
 1.31A 6dwnA-4tpnA:
26.4		 6dwnA-4tpnA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE

(Plasmodium
vivax) 		PF00082
(Peptidase_S8) 		5 LEU A 413
PHE A 435
ASP A 316
GLY A 433
PHE A 458
 None
 1.29A 6dwnA-4tr2A:
undetectable		 6dwnA-4tr2A:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyr ACETYL-COA
ACETYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 SER A 119
LEU A  53
ASN A  55
ASP A 251
ASP A  28
 None
 1.21A 6dwnA-4wyrA:
undetectable		 6dwnA-4wyrA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydw DARPIN 44C12V5

(synthetic
construct) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU A  33
ASP A  57
GLY A  25
ASP A  27
ILE A  95
 None
 1.32A 6dwnA-4ydwA:
undetectable		 6dwnA-4ydwA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztd PROLIFERATING CELL
NUCLEAR ANTIGEN

(Homo sapiens) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 ASN A  36
LEU A  50
ASP A 243
GLY A  56
PHE A  57
 None
 1.37A 6dwnA-4ztdA:
undetectable		 6dwnA-4ztdA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN

(Thauera
aromatica) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 LEU A 318
PHE A 317
GLY A 329
PHE A 392
ASP A 390
 None
 1.25A 6dwnA-5bwdA:
undetectable		 6dwnA-5bwdA:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN

(Thauera
aromatica) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 SER A 754
ASN A 862
PHE A 860
ASP A 671
ASP A 857
 None
 1.22A 6dwnA-5bwdA:
undetectable		 6dwnA-5bwdA:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL

(Homo sapiens) 		PF00180
(Iso_dh) 		5 ASN B  94
ASN B  93
ASN B 239
GLY B 133
ILE B 161
 None
 1.33A 6dwnA-5grhB:
undetectable		 6dwnA-5grhB:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgc SERPIN

(Taeniopygia
guttata) 		PF00079
(Serpin) 		5 ASN A  35
PHE A  38
PHE A  87
PHE A 101
ILE A 304
 None
 1.27A 6dwnA-5hgcA:
undetectable		 6dwnA-5hgcA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijj SPX DOMAIN

(Chaetomium
thermophilum) 		PF03105
(SPX) 		5 PHE A 153
LEU A 112
PHE A 115
ASP A  59
ILE A 144
 None
 1.33A 6dwnA-5ijjA:
undetectable		 6dwnA-5ijjA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Flavobacterium
psychrophilum) 		PF10459
(Peptidase_S46) 		5 SER A 199
ASN A 115
PHE A 223
GLY A  85
ASP A  87
 None
 1.26A 6dwnA-5jxfA:
undetectable		 6dwnA-5jxfA:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF09797
(NatB_MDM20) 		5 LEU A 142
PHE A 484
GLY A 478
ASP A 480
ILE A 116
 None
 1.38A 6dwnA-5k04A:
undetectable		 6dwnA-5k04A:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kin TRYPTOPHAN SYNTHASE
ALPHA CHAIN
TRYPTOPHAN SYNTHASE
BETA CHAIN

(Streptococcus
pneumoniae;
Streptococcus
pneumoniae) 		PF00290
(Trp_syntA)
PF00291
(PALP) 		5 LEU A 131
PHE B  19
GLY B  17
PHE B  11
ASP B   9
 GOL  A 301 (-4.8A)
None
None
None
None
 1.01A 6dwnA-5kinA:
undetectable		 6dwnA-5kinA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsk KINETOCHORE-ASSOCIAT
ED PROTEIN DSN1
HOMOLOG
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG

(Homo sapiens;
Homo sapiens) 		PF08202
(MIS13)
PF08641
(Mis14) 		5 LEU N  52
PHE D 178
ASP D 180
GLY D 181
ASP D 185
 None
 1.27A 6dwnA-5lskN:
undetectable		 6dwnA-5lskN:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE KDPC
SUBUNIT

(Escherichia
coli) 		PF02669
(KdpC) 		5 SER C 124
ASN C 182
LEU C 181
ASP C 129
GLY C  56
 None
 1.35A 6dwnA-5mrwC:
undetectable		 6dwnA-5mrwC:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyn DEHYDRATASE,
ILVD/EDD FAMILY

(Caulobacter
vibrioides) 		no annotation 5 SER A 502
ASN A 104
LEU A 573
ASP A 568
GLY A 570
 None
 1.18A 6dwnA-5oynA:
undetectable		 6dwnA-5oynA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN

(Escherichia
coli;
Streptococcus
pyogenes) 		PF12892
(FctA)
PF13416
(SBP_bac_8) 		5 SER A 407
PHE A 432
LEU A 473
ASP A 409
ILE A 414
 None
 1.31A 6dwnA-5ttdA:
undetectable		 6dwnA-5ttdA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpu 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Acinetobacter
baumannii) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		5 LEU A 295
ASN A 260
PHE A 261
ASP A 158
GLY A 126
 None
None
None
3PG  A 603 (-2.4A)
None
 1.07A 6dwnA-5vpuA:
undetectable		 6dwnA-5vpuA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzu BETA-XYLANASE

(Bispora sp.
MEY-1) 		no annotation 5 PHE A 238
ASN A 234
ASP A 184
GLY A 215
ILE A 200
 None
 1.10A 6dwnA-5xzuA:
undetectable		 6dwnA-5xzuA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 5 ASN A 736
ASN A 761
LEU A 733
ASN A 732
GLY A 687
 None
None
None
NAG  A 914 (-1.9A)
None
 1.16A 6dwnA-5zlnA:
undetectable		 6dwnA-5zlnA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia x
hybrida) 		no annotation 5 SER A  57
ASN A 156
PHE A 174
ASP A  30
GLY A  28
 None
 1.26A 6dwnA-6ap6A:
undetectable		 6dwnA-6ap6A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia x
hybrida) 		no annotation 5 SER A  57
PHE A 174
ASP A  30
GLY A  28
PHE A  27
 None
None
None
None
TLF  A 300 (-3.8A)
 1.18A 6dwnA-6ap6A:
undetectable		 6dwnA-6ap6A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk6 HENDRA VIRUS MATRIX
PROTEIN

(Hendra
henipavirus) 		no annotation 5 ASN A 205
LEU A 239
ASP A 260
GLY A 347
PHE A 266
 None
 1.29A 6dwnA-6bk6A:
undetectable		 6dwnA-6bk6A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT B

(Flavobacterium
johnsoniae) 		no annotation 5 SER B 131
LEU B 234
GLY B 259
ASP B 255
ILE B 136
 None
 1.38A 6dwnA-6btmB:
undetectable		 6dwnA-6btmB:
12.35