SIMILAR PATTERNS OF AMINO ACIDS FOR 6DWN_A_AQ4A602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)

(Ruminiclostridium
thermocellum) 		PF01270
(Glyco_hydro_8) 		5 SER A 272
ASN A 330
ASP A 274
GLY A 320
ASP A 319
 None
 1.10A 6dwnA-1cemA:
0.0		 6dwnA-1cemA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ASN A 205
ASN A 239
ASN A 310
ASP A 356
ASP A 362
 None
 1.37A 6dwnA-1e8cA:
0.0		 6dwnA-1e8cA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6f PLACENTAL LACTOGEN

(Ovis aries) 		PF00103
(Hormone_1) 		5 LEU A  18
PHE A  22
PHE A  83
ASP A  79
ILE A  75
 None
 1.31A 6dwnA-1f6fA:
undetectable		 6dwnA-1f6fA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTM, FLAVOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 ASN C  55
LEU C  31
ASP C 115
GLY C 110
ILE C 170
 None
None
FAD  C1922 (-2.9A)
FAD  C1922 (-3.7A)
None
 1.16A 6dwnA-1ffvC:
undetectable		 6dwnA-1ffvC:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTM, FLAVOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 PHE C 153
LEU C 224
ASP C 115
GLY C 119
ILE C 170
 None
None
FAD  C1922 (-2.9A)
None
None
 1.34A 6dwnA-1ffvC:
undetectable		 6dwnA-1ffvC:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g3n V-CYCLIN

(Human
gammaherpesvirus
8) 		PF00134
(Cyclin_N)
PF09080
(K-cyclin_vir_C) 		5 SER C 245
ASN C  77
LEU C 150
GLY C 190
ASP C  80
 None
 1.38A 6dwnA-1g3nC:
0.0		 6dwnA-1g3nC:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h14 ENDO-1,4-BETA-XYLANA
SE

(Pseudoalteromonas
haloplanktis) 		PF01270
(Glyco_hydro_8) 		5 ASN A 402
ASN A 401
LEU A 154
ASN A 155
GLY A 161
 None
 1.30A 6dwnA-1h14A:
undetectable		 6dwnA-1h14A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkw DIAMINOPIMELATE
DECARBOXYLASE

(Mycobacterium
tuberculosis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 PHE A  43
LEU A 433
PHE A  74
GLY A 403
ILE A 381
 None
 1.33A 6dwnA-1hkwA:
undetectable		 6dwnA-1hkwA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxh 3BETA/17BETA-HYDROXY
STEROID
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13561
(adh_short_C2) 		5 ASN A  86
ASN A 135
LEU A  84
GLY A  13
ILE A 186
 None
 1.31A 6dwnA-1hxhA:
undetectable		 6dwnA-1hxhA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC

(Canis lupus) 		PF00561
(Abhydrolase_1) 		5 SER A  99
PHE A  62
LEU A 139
ASP A 130
PHE A 163
 None
 1.15A 6dwnA-1k8qA:
0.0		 6dwnA-1k8qA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Geobacillus
stearothermophilus) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		5 LEU A 295
ASN A 259
PHE A 260
ASP A 154
GLY A 121
 None
None
None
2PG  A 801 (-2.6A)
None
 1.06A 6dwnA-1o99A:
0.0		 6dwnA-1o99A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oht CG14704 PROTEIN

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		5 SER A 108
ASN A 179
PHE A 175
GLY A 151
PHE A 166
 None
TLA  A1188 (-3.2A)
None
None
None
 1.35A 6dwnA-1ohtA:
undetectable		 6dwnA-1ohtA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2j PEPTIDOGLYCAN
RECOGNITION PROTEIN
SA CG11709-PA

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		5 SER A  49
LEU A 163
PHE A 111
ASP A  83
ASP A 122
 None
 1.36A 6dwnA-1s2jA:
undetectable		 6dwnA-1s2jA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Synechococcus
elongatus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 SER A  44
LEU A 300
ASP A  46
ASP A 382
ILE A  41
 None
None
None
None
HDF  A5486 (-3.9A)
 1.19A 6dwnA-1tezA:
undetectable		 6dwnA-1tezA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wao SERINE/THREONINE
PROTEIN PHOSPHATASE
5

(Homo sapiens) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5) 		5 SER 1 403
ASN 1 269
LEU 1 300
ASP 1 383
GLY 1 354
 None
 1.17A 6dwnA-1wao1:
undetectable		 6dwnA-1wao1:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we0 ALKYL HYDROPEROXIDE
REDUCTASE C

(Amphibacillus
xylanus) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		5 LEU A   2
PHE A 123
GLY A 121
ASP A 119
ILE A 141
 None
 1.35A 6dwnA-1we0A:
undetectable		 6dwnA-1we0A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB

(Mycobacterium
tuberculosis) 		PF13350
(Y_phosphatase3) 		5 ASN A 193
LEU A 190
GLY A 230
ASP A 229
ILE A 203
 None
 1.24A 6dwnA-1ywfA:
undetectable		 6dwnA-1ywfA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z34 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Trichomonas
vaginalis) 		PF01048
(PNP_UDP_1) 		5 SER A 182
LEU A 229
GLY A  89
PHE A 221
ILE A  69
 None
 1.15A 6dwnA-1z34A:
undetectable		 6dwnA-1z34A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 SER A 431
ASN A 260
ASN A 257
ASP A 520
GLY A 518
 None
 1.20A 6dwnA-1z8lA:
undetectable		 6dwnA-1z8lA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf6 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF13088
(BNR_2) 		5 ASN A 448
ASN A 432
ASN A 417
GLY A 361
PHE A 362
 None
 1.30A 6dwnA-2bf6A:
undetectable		 6dwnA-2bf6A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d99 GENERAL
TRANSCRIPTION FACTOR
II-I REPEAT
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF02946
(GTF2I) 		5 SER A  73
PHE A  78
LEU A  80
ASP A  17
ILE A  69
 None
 1.37A 6dwnA-2d99A:
undetectable		 6dwnA-2d99A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dy3 ALANINE RACEMASE

(Corynebacterium
glutamicum) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 SER A 288
ASP A 295
GLY A 293
ASP A 292
ILE A 309
 None
 1.25A 6dwnA-2dy3A:
undetectable		 6dwnA-2dy3A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6t UNCHARACTERIZED
PROTEIN, HOMOLOG
HI1244 FROM
HAEMOPHILUS
INFLUENZAE

(Clostridium
acetobutylicum) 		PF08942
(DUF1919) 		5 PHE A  99
PHE A  95
GLY A  91
PHE A  66
ILE A 108
 None
 1.35A 6dwnA-2g6tA:
undetectable		 6dwnA-2g6tA:
12.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens) 		PF00067
(p450) 		6 PHE A 226
ASN A 257
ASP A 313
GLY A 316
ASP A 320
ILE A 386
 BHF  A 800 (-3.6A)
None
BHF  A 800 (-3.9A)
BHF  A 800 (-3.8A)
BHF  A 800 (-4.0A)
HEM  A 900 (-4.0A)
 0.55A 6dwnA-2hi4A:
55.4		 6dwnA-2hi4A:
81.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2izv SUPPRESSOR OF
CYTOKINE SIGNALING 4

(Homo sapiens) 		PF00017
(SH2)
PF07525
(SOCS_box) 		5 SER A 323
ASN A 282
LEU A 278
GLY A 289
PHE A 387
 None
None
None
CL  A1432 ( 4.0A)
CL  A1432 ( 4.6A)
 1.35A 6dwnA-2izvA:
undetectable		 6dwnA-2izvA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jqj DNA DAMAGE RESPONSE
PROTEIN KINASE DUN1

(Saccharomyces
cerevisiae) 		PF00498
(FHA) 		5 SER A 101
ASN A 108
LEU A 119
PHE A  80
PHE A 133
 None
 1.37A 6dwnA-2jqjA:
undetectable		 6dwnA-2jqjA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jr0 N UTILIZATION
SUBSTANCE PROTEIN B
HOMOLOG

(Aquifex
aeolicus) 		PF01029
(NusB) 		5 SER A  73
PHE A 122
ASP A  75
GLY A  78
ILE A  65
 None
 1.34A 6dwnA-2jr0A:
undetectable		 6dwnA-2jr0A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qde MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Aromatoleum
aromaticum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 SER A 302
ASP A  49
GLY A  33
ASP A  32
ILE A 332
 None
 1.32A 6dwnA-2qdeA:
undetectable		 6dwnA-2qdeA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rag DIPEPTIDASE

(Caulobacter
vibrioides) 		PF01244
(Peptidase_M19) 		5 LEU A  82
ASP A  51
GLY A  92
ASP A  91
ILE A 379
 None
 1.08A 6dwnA-2ragA:
undetectable		 6dwnA-2ragA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE

(Dictyostelium
discoideum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		5 SER A 191
ASN A  22
LEU A 129
GLY A 173
ILE A 144
 None
None
None
FAD  A1587 (-3.4A)
None
 1.31A 6dwnA-2uuuA:
undetectable		 6dwnA-2uuuA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		5 ASN A 474
PHE A 593
GLY A 576
PHE A 577
ILE A 567
 None
 1.37A 6dwnA-2v26A:
undetectable		 6dwnA-2v26A:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9t ROUNDABOUT HOMOLOG 1
SLIT HOMOLOG 2
PROTEIN N-PRODUCT

(Homo sapiens;
Homo sapiens) 		PF13927
(Ig_3)
PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		5 SER A  75
ASN B 334
ASN B 358
LEU B 331
GLY B 288
 None
 1.30A 6dwnA-2v9tA:
undetectable		 6dwnA-2v9tA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK) 		PF00202
(Aminotran_3) 		5 ASN A 351
PHE A 348
ASP A 423
GLY A 425
PHE A  85
 None
 1.35A 6dwnA-2ykyA:
undetectable		 6dwnA-2ykyA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn9 POTASSIUM-TRANSPORTI
NG ATPASE ALPHA
CHAIN 1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF09040
(H-K_ATPase_N)
PF13246
(Cation_ATPase) 		5 SER A 169
LEU A 759
ASP A 749
ASP A 730
ILE A 166
 None
 1.38A 6dwnA-2yn9A:
undetectable		 6dwnA-2yn9A:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3d PUTATIVE MORPHINE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		5 LEU A 196
ASP A  49
GLY A  21
PHE A  20
ILE A 165
 CA  A 281 (-4.2A)
None
None
None
None
 1.12A 6dwnA-3b3dA:
undetectable		 6dwnA-3b3dA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfh MANDELATE RACEMASE

(Vibrionales
bacterium
SWAT-3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASN A 262
ASN A 263
PHE A 261
ASP A 234
ILE A 276
 None
 1.32A 6dwnA-3dfhA:
undetectable		 6dwnA-3dfhA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e38 TWO-DOMAIN PROTEIN
CONTAINING PREDICTED
PHP-LIKE
METAL-DEPENDENT
PHOSPHOESTERASE

(Bacteroides
vulgatus) 		PF16392
(DUF5001) 		5 PHE A 154
ASN A 156
ASP A  42
GLY A 211
ILE A 109
 None
 1.07A 6dwnA-3e38A:
undetectable		 6dwnA-3e38A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eza PHOSPHOTRANSFERASE
SYSTEM, ENZYME I

(Escherichia
coli) 		PF00391
(PEP-utilizers)
PF05524
(PEP-utilisers_N) 		5 SER A 166
LEU A 142
ASP A 132
GLY A 134
ILE A  57
 None
 1.14A 6dwnA-3ezaA:
undetectable		 6dwnA-3ezaA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fed GLUTAMATE
CARBOXYPEPTIDASE III

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 SER A 421
ASN A 250
ASN A 247
ASP A 510
GLY A 508
 None
None
BIX  A   1 (-3.2A)
None
BIX  A   1 (-3.4A)
 1.17A 6dwnA-3fedA:
undetectable		 6dwnA-3fedA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fky GLUTAMINE SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		5 LEU A 117
PHE A 118
ASP A 213
PHE A 128
ILE A  31
 None
 1.29A 6dwnA-3fkyA:
undetectable		 6dwnA-3fkyA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goz LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN

(Legionella
pneumophila) 		no annotation 5 ASN A 148
ASN A 177
LEU A 145
ASN A 144
GLY A  89
 None
 1.02A 6dwnA-3gozA:
undetectable		 6dwnA-3gozA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5

(Homo sapiens) 		PF00149
(Metallophos)
PF08321
(PPP5) 		5 SER A 403
ASN A 269
LEU A 300
ASP A 383
GLY A 354
 None
 1.22A 6dwnA-3h68A:
undetectable		 6dwnA-3h68A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbn UDP-SUGAR HYDROLASE

(Campylobacter
jejuni) 		no annotation 5 SER A 173
ASP A 168
GLY A 166
PHE A  15
ILE A 188
 None
None
UDP  A 301 (-3.5A)
None
None
 1.04A 6dwnA-3hbnA:
undetectable		 6dwnA-3hbnA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbu SECRETED PROTEASE C

(Dickeya
chrysanthemi) 		PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		5 ASN P  98
PHE P  97
ASN P 135
PHE P  94
ILE P 190
 None
 1.26A 6dwnA-3hbuP:
undetectable		 6dwnA-3hbuP:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm0 PROBABLE
THIOESTERASE

(Bartonella
henselae) 		PF03061
(4HBT) 		5 LEU A  60
ASN A  57
PHE A  71
PHE A 104
ILE A  92
 None
 1.33A 6dwnA-3hm0A:
undetectable		 6dwnA-3hm0A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ioy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Novosphingobium
aromaticivorans) 		PF00106
(adh_short) 		5 SER A 256
ASN A  16
ASN A  92
GLY A 240
ASP A 237
 None
 1.36A 6dwnA-3ioyA:
undetectable		 6dwnA-3ioyA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Thermoanaerobacter
pseudethanolicus) 		PF00724
(Oxidored_FMN) 		5 ASN A  76
ASP A  71
GLY A  33
ASP A  32
ILE A 110
 None
 1.26A 6dwnA-3krzA:
undetectable		 6dwnA-3krzA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvn ESTERASE ESTA

(Pseudomonas
aeruginosa) 		no annotation 5 SER X  14
ASN X 213
LEU X 186
ASP X  13
GLY X 145
 C8E  X 623 (-2.9A)
None
None
C8E  X 623 ( 4.2A)
None
 1.36A 6dwnA-3kvnX:
undetectable		 6dwnA-3kvnX:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m19 VARIABLE LYMPHOCYTE
RECEPTOR A DIVERSITY
REGION

(Petromyzon
marinus) 		PF13855
(LRR_8) 		5 ASN A  68
ASN A  92
LEU A  65
ASN A  64
GLY A  22
 None
 1.10A 6dwnA-3m19A:
undetectable		 6dwnA-3m19A:
15.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pm0 CYTOCHROME P450 1B1

(Homo sapiens) 		PF00067
(p450) 		5 ASN A 228
PHE A 231
PHE A 268
ASP A 326
GLY A 329
 BHF  A 800 (-4.2A)
BHF  A 800 (-3.4A)
BHF  A 800 ( 3.8A)
BHF  A 800 (-3.4A)
BHF  A 800 ( 4.0A)
 1.19A 6dwnA-3pm0A:
48.0		 6dwnA-3pm0A:
58.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pm0 CYTOCHROME P450 1B1

(Homo sapiens) 		PF00067
(p450) 		7 PHE A 231
ASN A 265
PHE A 268
ASP A 326
GLY A 329
ASP A 333
ILE A 399
 BHF  A 800 (-3.4A)
None
BHF  A 800 ( 3.8A)
BHF  A 800 (-3.4A)
BHF  A 800 ( 4.0A)
BHF  A 800 ( 4.1A)
HEM  A 900 (-4.0A)
 0.62A 6dwnA-3pm0A:
48.0		 6dwnA-3pm0A:
58.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rw7 NUCLEAR RNA EXPORT
FACTOR 1

(Homo sapiens) 		PF09162
(Tap-RNA_bind) 		5 ASN A 301
ASN A 325
LEU A 298
ASN A 297
GLY A 231
 None
 1.24A 6dwnA-3rw7A:
undetectable		 6dwnA-3rw7A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sll PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		5 SER A 191
ASN A  25
ASN A  19
ASP A 132
GLY A 111
 None
 1.27A 6dwnA-3sllA:
undetectable		 6dwnA-3sllA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tji MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Enterobacter
sp. 638) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASN A 260
ASN A 261
PHE A 259
ASP A 232
ILE A 274
 None
None
None
MG  A 601 ( 4.8A)
None
 1.38A 6dwnA-3tjiA:
undetectable		 6dwnA-3tjiA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uqz DNA PROCESSING
PROTEIN DPRA

(Streptococcus
pneumoniae) 		PF02481
(DNA_processg_A) 		5 SER A 140
LEU A 255
ASP A 147
GLY A 145
ILE A 138
 None
 1.21A 6dwnA-3uqzA:
undetectable		 6dwnA-3uqzA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C

(Homo sapiens) 		PF00560
(LRR_1)
PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 ASN A 277
ASN A 301
LEU A 274
ASN A 273
GLY A 228
 None
 1.18A 6dwnA-3zyjA:
undetectable		 6dwnA-3zyjA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
NETRIN-G1

(Homo sapiens;
Homo sapiens) 		PF00560
(LRR_1)
PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8)
PF00053
(Laminin_EGF)
PF00055
(Laminin_N) 		5 SER B 228
ASN A 277
ASN A 301
LEU A 274
GLY A 228
 None
 1.24A 6dwnA-3zyjB:
undetectable		 6dwnA-3zyjB:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 ASN A 289
ASN A 313
LEU A 286
ASN A 285
GLY A 240
 None
 1.18A 6dwnA-3zynA:
undetectable		 6dwnA-3zynA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B

(Mus musculus) 		PF00560
(LRR_1)
PF07679
(I-set)
PF13855
(LRR_8) 		5 ASN A 289
ASN A 313
LEU A 286
ASN A 285
GLY A 240
 None
 1.23A 6dwnA-3zyoA:
undetectable		 6dwnA-3zyoA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7p UDP-GLUCOSE
DEHYDROGENASE

(Sphingomonas
elodea) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 SER A  88
ASN A 212
GLY A 262
PHE A 324
ASP A 330
 None
 1.31A 6dwnA-4a7pA:
undetectable		 6dwnA-4a7pA:
10.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		5 ASN A 222
ASN A 223
LEU A 254
PHE A 258
PHE A 319
 BHF  A 602 ( 3.8A)
None
None
BHF  A 602 ( 3.9A)
BHF  A 602 ( 4.7A)
 1.17A 6dwnA-4i8vA:
62.1		 6dwnA-4i8vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		5 ASN A 223
LEU A 254
ASN A 255
PHE A 258
PHE A 319
 None
None
None
BHF  A 602 ( 3.9A)
BHF  A 602 ( 4.7A)
 1.01A 6dwnA-4i8vA:
62.1		 6dwnA-4i8vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		6 SER A 120
ASN A 222
PHE A 224
ASP A 313
GLY A 316
PHE A 319
 BHF  A 602 ( 4.5A)
BHF  A 602 ( 3.8A)
BHF  A 602 (-3.3A)
BHF  A 602 (-3.7A)
BHF  A 602 (-3.5A)
BHF  A 602 ( 4.7A)
 1.49A 6dwnA-4i8vA:
62.1		 6dwnA-4i8vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		6 SER A 120
PHE A 224
ASP A 313
GLY A 316
PHE A 319
ASP A 320
 BHF  A 602 ( 4.5A)
BHF  A 602 (-3.3A)
BHF  A 602 (-3.7A)
BHF  A 602 (-3.5A)
BHF  A 602 ( 4.7A)
BHF  A 602 (-3.7A)
 1.48A 6dwnA-4i8vA:
62.1		 6dwnA-4i8vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		9 SER A 122
ASN A 222
ASN A 223
PHE A 224
PHE A 258
ASP A 313
GLY A 316
PHE A 319
ILE A 386
 HEM  A 601 (-3.4A)
BHF  A 602 ( 3.8A)
None
BHF  A 602 (-3.3A)
BHF  A 602 ( 3.9A)
BHF  A 602 (-3.7A)
BHF  A 602 (-3.5A)
BHF  A 602 ( 4.7A)
HEM  A 601 (-3.6A)
 0.69A 6dwnA-4i8vA:
62.1		 6dwnA-4i8vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		10 SER A 122
ASN A 223
PHE A 224
ASN A 255
PHE A 258
ASP A 313
GLY A 316
PHE A 319
ASP A 320
ILE A 386
 HEM  A 601 (-3.4A)
None
BHF  A 602 (-3.3A)
None
BHF  A 602 ( 3.9A)
BHF  A 602 (-3.7A)
BHF  A 602 (-3.5A)
BHF  A 602 ( 4.7A)
BHF  A 602 (-3.7A)
HEM  A 601 (-3.6A)
 0.48A 6dwnA-4i8vA:
62.1		 6dwnA-4i8vA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irt UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF15892
(BNR_4) 		5 SER A 367
ASN A 280
ASN A 302
ASP A 363
GLY A 341
 CL  A 502 (-4.3A)
None
None
None
None
 1.19A 6dwnA-4irtA:
undetectable		 6dwnA-4irtA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxf TREHALOSE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 SER A 459
LEU A 389
GLY A 419
ASP A 416
ILE A 434
 None
None
None
GOL  A 704 (-3.5A)
None
 1.38A 6dwnA-4lxfA:
undetectable		 6dwnA-4lxfA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 ASN A 570
ASN A 521
GLY A 613
ASP A 660
ILE A 540
 None
NAG  A 805 ( 4.5A)
None
None
None
 1.25A 6dwnA-4m7eA:
undetectable		 6dwnA-4m7eA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4non FERROUS IRON UPTAKE
TRANSPORTER PROTEIN
B

(Streptococcus
thermophilus) 		PF02421
(FeoB_N) 		5 ASN A   9
LEU A  97
ASN A  84
GLY A  13
ILE A 115
 ASN  A   9 ( 0.6A)
LEU  A  97 ( 0.6A)
ASN  A  84 ( 0.6A)
GLY  A  13 (-0.0A)
ILE  A 115 ( 0.4A)
 1.33A 6dwnA-4nonA:
undetectable		 6dwnA-4nonA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pq8 DESIGNED PROTEIN
OR465

(synthetic
construct) 		PF00560
(LRR_1)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 ASN A 126
ASN A 150
LEU A 123
ASN A 122
GLY A  79
 None
None
None
CL  A 301 (-4.3A)
None
 1.14A 6dwnA-4pq8A:
undetectable		 6dwnA-4pq8A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psj OR464

(synthetic
construct) 		PF12354
(Internalin_N)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 ASN A 126
ASN A 150
LEU A 123
ASN A 122
GLY A  79
 None
 1.09A 6dwnA-4psjA:
undetectable		 6dwnA-4psjA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA

(Eptatretus
burgeri;
Mus musculus) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 ASN A 315
ASN A 340
LEU A 312
ASN A 311
GLY A 266
 None
None
None
NAG  A 505 (-1.9A)
None
 1.10A 6dwnA-4qdhA:
undetectable		 6dwnA-4qdhA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5c LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 ASN A 118
ASN A 142
LEU A 115
ASN A 114
GLY A  71
 None
 1.12A 6dwnA-4r5cA:
undetectable		 6dwnA-4r5cA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5d LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 ASN A 118
ASN A 142
LEU A 115
ASN A 114
GLY A  71
 None
 1.10A 6dwnA-4r5dA:
undetectable		 6dwnA-4r5dA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6g LEUCINE RICH REPEATS
DLRR_K

(synthetic
construct) 		PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 ASN A 118
ASN A 142
LEU A 115
ASN A 114
GLY A  71
 None
 1.13A 6dwnA-4r6gA:
undetectable		 6dwnA-4r6gA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei) 		PF00067
(p450) 		5 ASN A 390
PHE A 395
LEU A 393
PHE A 295
ILE A 244
 SO4  A 506 ( 3.8A)
SO4  A 511 (-4.7A)
None
None
None
 1.31A 6dwnA-4tpnA:
26.4		 6dwnA-4tpnA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE

(Plasmodium
vivax) 		PF00082
(Peptidase_S8) 		5 LEU A 413
PHE A 435
ASP A 316
GLY A 433
PHE A 458
 None
 1.29A 6dwnA-4tr2A:
undetectable		 6dwnA-4tr2A:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyr ACETYL-COA
ACETYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 SER A 119
LEU A  53
ASN A  55
ASP A 251
ASP A  28
 None
 1.21A 6dwnA-4wyrA:
undetectable		 6dwnA-4wyrA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydw DARPIN 44C12V5

(synthetic
construct) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU A  33
ASP A  57
GLY A  25
ASP A  27
ILE A  95
 None
 1.32A 6dwnA-4ydwA:
undetectable		 6dwnA-4ydwA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztd PROLIFERATING CELL
NUCLEAR ANTIGEN

(Homo sapiens) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 ASN A  36
LEU A  50
ASP A 243
GLY A  56
PHE A  57
 None
 1.37A 6dwnA-4ztdA:
undetectable		 6dwnA-4ztdA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN

(Thauera
aromatica) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 LEU A 318
PHE A 317
GLY A 329
PHE A 392
ASP A 390
 None
 1.25A 6dwnA-5bwdA:
undetectable		 6dwnA-5bwdA:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN

(Thauera
aromatica) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 SER A 754
ASN A 862
PHE A 860
ASP A 671
ASP A 857
 None
 1.22A 6dwnA-5bwdA:
undetectable		 6dwnA-5bwdA:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL

(Homo sapiens) 		PF00180
(Iso_dh) 		5 ASN B  94
ASN B  93
ASN B 239
GLY B 133
ILE B 161
 None
 1.33A 6dwnA-5grhB:
undetectable		 6dwnA-5grhB:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgc SERPIN

(Taeniopygia
guttata) 		PF00079
(Serpin) 		5 ASN A  35
PHE A  38
PHE A  87
PHE A 101
ILE A 304
 None
 1.27A 6dwnA-5hgcA:
undetectable		 6dwnA-5hgcA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijj SPX DOMAIN

(Chaetomium
thermophilum) 		PF03105
(SPX) 		5 PHE A 153
LEU A 112
PHE A 115
ASP A  59
ILE A 144
 None
 1.33A 6dwnA-5ijjA:
undetectable		 6dwnA-5ijjA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Flavobacterium
psychrophilum) 		PF10459
(Peptidase_S46) 		5 SER A 199
ASN A 115
PHE A 223
GLY A  85
ASP A  87
 None
 1.26A 6dwnA-5jxfA:
undetectable		 6dwnA-5jxfA:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF09797
(NatB_MDM20) 		5 LEU A 142
PHE A 484
GLY A 478
ASP A 480
ILE A 116
 None
 1.38A 6dwnA-5k04A:
undetectable		 6dwnA-5k04A:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kin TRYPTOPHAN SYNTHASE
ALPHA CHAIN
TRYPTOPHAN SYNTHASE
BETA CHAIN

(Streptococcus
pneumoniae;
Streptococcus
pneumoniae) 		PF00290
(Trp_syntA)
PF00291
(PALP) 		5 LEU A 131
PHE B  19
GLY B  17
PHE B  11
ASP B   9
 GOL  A 301 (-4.8A)
None
None
None
None
 1.01A 6dwnA-5kinA:
undetectable		 6dwnA-5kinA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsk KINETOCHORE-ASSOCIAT
ED PROTEIN DSN1
HOMOLOG
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG

(Homo sapiens;
Homo sapiens) 		PF08202
(MIS13)
PF08641
(Mis14) 		5 LEU N  52
PHE D 178
ASP D 180
GLY D 181
ASP D 185
 None
 1.27A 6dwnA-5lskN:
undetectable		 6dwnA-5lskN:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE KDPC
SUBUNIT

(Escherichia
coli) 		PF02669
(KdpC) 		5 SER C 124
ASN C 182
LEU C 181
ASP C 129
GLY C  56
 None
 1.35A 6dwnA-5mrwC:
undetectable		 6dwnA-5mrwC:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyn DEHYDRATASE,
ILVD/EDD FAMILY

(Caulobacter
vibrioides) 		no annotation 5 SER A 502
ASN A 104
LEU A 573
ASP A 568
GLY A 570
 None
 1.18A 6dwnA-5oynA:
undetectable		 6dwnA-5oynA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN

(Escherichia
coli;
Streptococcus
pyogenes) 		PF12892
(FctA)
PF13416
(SBP_bac_8) 		5 SER A 407
PHE A 432
LEU A 473
ASP A 409
ILE A 414
 None
 1.31A 6dwnA-5ttdA:
undetectable		 6dwnA-5ttdA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpu 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Acinetobacter
baumannii) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		5 LEU A 295
ASN A 260
PHE A 261
ASP A 158
GLY A 126
 None
None
None
3PG  A 603 (-2.4A)
None
 1.07A 6dwnA-5vpuA:
undetectable		 6dwnA-5vpuA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzu BETA-XYLANASE

(Bispora sp.
MEY-1) 		no annotation 5 PHE A 238
ASN A 234
ASP A 184
GLY A 215
ILE A 200
 None
 1.10A 6dwnA-5xzuA:
undetectable		 6dwnA-5xzuA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 5 ASN A 736
ASN A 761
LEU A 733
ASN A 732
GLY A 687
 None
None
None
NAG  A 914 (-1.9A)
None
 1.16A 6dwnA-5zlnA:
undetectable		 6dwnA-5zlnA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia x
hybrida) 		no annotation 5 SER A  57
ASN A 156
PHE A 174
ASP A  30
GLY A  28
 None
 1.26A 6dwnA-6ap6A:
undetectable		 6dwnA-6ap6A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia x
hybrida) 		no annotation 5 SER A  57
PHE A 174
ASP A  30
GLY A  28
PHE A  27
 None
None
None
None
TLF  A 300 (-3.8A)
 1.18A 6dwnA-6ap6A:
undetectable		 6dwnA-6ap6A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk6 HENDRA VIRUS MATRIX
PROTEIN

(Hendra
henipavirus) 		no annotation 5 ASN A 205
LEU A 239
ASP A 260
GLY A 347
PHE A 266
 None
 1.29A 6dwnA-6bk6A:
undetectable		 6dwnA-6bk6A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT B

(Flavobacterium
johnsoniae) 		no annotation 5 SER B 131
LEU B 234
GLY B 259
ASP B 255
ILE B 136
 None
 1.38A 6dwnA-6btmB:
undetectable		 6dwnA-6btmB:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a99 PUTRESCINE-BINDING
PROTEIN

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		4 ILE A 140
SER A 267
ALA A 155
LEU A 172
 None
 1.04A 6dwnA-1a99A:
0.0		 6dwnA-1a99A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf5 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		4 ILE A 647
SER A 708
ALA A 611
LEU A 569
 None
 0.92A 6dwnA-1bf5A:
0.0		 6dwnA-1bf5A:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bix AP ENDONUCLEASE 1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 ILE A  91
SER A 135
LEU A 316
LYS A  58
 None
 0.99A 6dwnA-1bixA:
0.0		 6dwnA-1bixA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bsg BETA LACTAMASE

(Streptomyces
albus) 		PF13354
(Beta-lactamase2) 		4 ILE A 127
SER A 126
ALA A  79
LEU A 193
 None
 0.98A 6dwnA-1bsgA:
0.0		 6dwnA-1bsgA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci7 PROTEIN (THYMIDYLATE
SYNTHASE)

(Pneumocystis
carinii) 		PF00303
(Thymidylat_synt) 		4 ILE A  99
SER A  98
ALA A  89
LEU A 109
 None
 0.96A 6dwnA-1ci7A:
0.0		 6dwnA-1ci7A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE

(Methylobacterium
extorquens) 		PF09176
(Mpt_N) 		4 ILE A 215
SER A 214
ALA A 186
LEU A 204
 None
 1.03A 6dwnA-1luaA:
0.0		 6dwnA-1luaA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4s ASPARTATE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		4 ILE A 226
SER A 248
ALA A 165
LEU A 187
 None
 1.01A 6dwnA-1o4sA:
0.0		 6dwnA-1o4sA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX

(Helicobacter
pylori) 		PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 ILE A 213
SER A 173
ALA A 240
LEU A 330
 None
 1.04A 6dwnA-1um8A:
undetectable		 6dwnA-1um8A:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xt0 GUANINE NUCLEOTIDE
EXCHANGE PROTEIN

(Legionella
pneumophila) 		PF01369
(Sec7) 		4 ILE B  24
ALA B  57
LEU B  62
LYS B 106
 None
 1.05A 6dwnA-1xt0B:
0.3		 6dwnA-1xt0B:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvx YFUA

(Yersinia
enterocolitica) 		PF13343
(SBP_bac_6) 		4 ILE A 124
SER A 123
ALA A 160
LEU A 165
 None
 1.02A 6dwnA-1xvxA:
undetectable		 6dwnA-1xvxA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhu HEMOGLOBIN B1A CHAIN

(Riftia
pachyptila) 		PF00042
(Globin) 		4 ILE C 144
SER C 145
ALA C 114
LEU C  75
 None
None
None
HEM  C 160 ( 4.7A)
 0.95A 6dwnA-1yhuC:
undetectable		 6dwnA-1yhuC:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjg SURFACE PROTEIN VSPA

(Borrelia
turicatae) 		PF01441
(Lipoprotein_6) 		4 ILE A  68
SER A  67
ALA A 104
LEU A 137
 None
 0.94A 6dwnA-1yjgA:
undetectable		 6dwnA-1yjgA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrz PROTEIN KINASE C,
IOTA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 ILE A 353
SER A 354
ALA A 346
LEU A 331
 None
 1.06A 6dwnA-1zrzA:
undetectable		 6dwnA-1zrzA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf4 NADPH-CYTOCHROME
P450 REDUCTASE

(Saccharomyces
cerevisiae) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 ILE A 288
SER A 290
ALA A 488
LEU A 499
 None
 0.99A 6dwnA-2bf4A:
undetectable		 6dwnA-2bf4A:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE

(Pseudomonas
syringae group
genomosp. 3) 		PF02615
(Ldh_2) 		4 ILE A 327
SER A 322
ALA A  46
LEU A  22
 None
 1.05A 6dwnA-2cwfA:
undetectable		 6dwnA-2cwfA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ga0 SURFACE PROTEIN VSPA

(Borrelia
turicatae) 		PF01441
(Lipoprotein_6) 		4 ILE A  68
SER A  67
ALA A 104
LEU A 137
 None
 0.94A 6dwnA-2ga0A:
undetectable		 6dwnA-2ga0A:
18.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens) 		PF00067
(p450) 		4 ILE A 117
ALA A 317
LEU A 497
LYS A 500
 None
HEM  A 900 ( 3.5A)
BHF  A 800 (-4.4A)
None
 0.42A 6dwnA-2hi4A:
55.4		 6dwnA-2hi4A:
81.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jhn 3-METHYLADENINE
DNA-GLYCOSYLASE

(Archaeoglobus
fulgidus) 		PF00730
(HhH-GPD) 		4 ILE A 131
SER A 132
ALA A 140
LEU A 180
 None
 1.06A 6dwnA-2jhnA:
undetectable		 6dwnA-2jhnA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfv ISOCITRATE
DEHYDROGENASE [NADP]

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		4 ILE A  72
SER A 307
ALA A 358
LEU A  36
 None
 1.07A 6dwnA-2qfvA:
undetectable		 6dwnA-2qfvA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2reb REC A

(Escherichia
coli) 		PF00154
(RecA) 		4 ILE A  93
SER A 117
ALA A 131
LEU A 178
 None
 1.03A 6dwnA-2rebA:
undetectable		 6dwnA-2rebA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rex RHO-RELATED
GTP-BINDING PROTEIN
RHO6

(Homo sapiens) 		PF00071
(Ras) 		4 ILE B 147
SER B 148
ALA B 156
LEU B 104
 None
None
UNX  B 559 ( 4.1A)
None
 1.02A 6dwnA-2rexB:
undetectable		 6dwnA-2rexB:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0f WSAF

(Geobacillus
stearothermophilus) 		no annotation 4 ILE A 226
ALA A 335
LEU A 312
LYS A 240
 None
 1.06A 6dwnA-2x0fA:
undetectable		 6dwnA-2x0fA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA

(Escherichia
coli) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 ILE A 606
SER A 605
ALA A 554
LEU A 616
 None
 0.96A 6dwnA-2xaxA:
undetectable		 6dwnA-2xaxA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 4 ILE A 434
SER A  11
ALA A 412
LEU A  19
 None
 1.07A 6dwnA-3a0fA:
undetectable		 6dwnA-3a0fA:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bol 5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		4 ILE A 528
SER A 529
ALA A 522
LEU A 544
 None
 1.04A 6dwnA-3bolA:
undetectable		 6dwnA-3bolA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bv4 FRUCTOSE-BISPHOSPHAT
E ALDOLASE A

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		4 ILE A  39
SER A  38
ALA A  31
LEU A  62
 None
None
13P  A3371 ( 4.3A)
None
 0.99A 6dwnA-3bv4A:
undetectable		 6dwnA-3bv4A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ILE A  93
SER A 117
ALA A 131
LEU A 178
 None
 1.03A 6dwnA-3cmtA:
undetectable		 6dwnA-3cmtA:
4.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ILE A1093
SER A1117
ALA A1131
LEU A1178
 None
 1.03A 6dwnA-3cmtA:
undetectable		 6dwnA-3cmtA:
4.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ILE A2093
SER A2117
ALA A2131
LEU A2178
 None
 1.03A 6dwnA-3cmtA:
undetectable		 6dwnA-3cmtA:
4.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ILE A3093
SER A3117
ALA A3131
LEU A3178
 None
 1.03A 6dwnA-3cmtA:
undetectable		 6dwnA-3cmtA:
4.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ILE A4093
SER A4117
ALA A4131
LEU A4178
 None
 1.03A 6dwnA-3cmtA:
undetectable		 6dwnA-3cmtA:
4.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ILE A  93
SER A 117
ALA A 131
LEU A 178
 None
 0.98A 6dwnA-3cmuA:
undetectable		 6dwnA-3cmuA:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ILE A1093
SER A1117
ALA A1131
LEU A1178
 None
 0.97A 6dwnA-3cmuA:
undetectable		 6dwnA-3cmuA:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ILE A2093
SER A2117
ALA A2131
LEU A2178
 None
 0.97A 6dwnA-3cmuA:
undetectable		 6dwnA-3cmuA:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ILE A3093
SER A3117
ALA A3131
LEU A3178
 None
 0.97A 6dwnA-3cmuA:
undetectable		 6dwnA-3cmuA:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ILE A4093
SER A4117
ALA A4131
LEU A4178
 None
 0.97A 6dwnA-3cmuA:
undetectable		 6dwnA-3cmuA:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ILE A5093
SER A5117
ALA A5131
LEU A5178
 None
 0.97A 6dwnA-3cmuA:
undetectable		 6dwnA-3cmuA:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ILE A1093
SER A1117
ALA A1131
LEU A1178
 None
 0.96A 6dwnA-3cmvA:
undetectable		 6dwnA-3cmvA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ILE A2093
SER A2117
ALA A2131
LEU A2178
 None
 1.03A 6dwnA-3cmvA:
undetectable		 6dwnA-3cmvA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3crr TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE

(Pseudomonas
aeruginosa) 		PF01715
(IPPT) 		4 ILE A 252
SER A 251
ALA A 238
LEU A 264
 None
 0.94A 6dwnA-3crrA:
undetectable		 6dwnA-3crrA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4m GLUTAREDOXIN-2,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00462
(Glutaredoxin) 		4 ILE A  69
SER A  70
ALA A  22
LEU A  13
 None
 0.95A 6dwnA-3d4mA:
undetectable		 6dwnA-3d4mA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doo SHIKIMATE
DEHYDROGENASE

(Staphylococcus
epidermidis) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ILE A 180
SER A 207
ALA A 118
LEU A 144
 None
 1.04A 6dwnA-3dooA:
undetectable		 6dwnA-3dooA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e15 GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE

(Plasmodium
vivax) 		PF01182
(Glucosamine_iso) 		4 ILE A 153
SER A 238
ALA A  43
LEU A  84
 None
 1.01A 6dwnA-3e15A:
undetectable		 6dwnA-3e15A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		4 ILE A 291
ALA A 332
LEU A 270
LYS A 490
 None
 0.99A 6dwnA-3g4gA:
undetectable		 6dwnA-3g4gA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B

(Homo sapiens) 		PF00268
(Ribonuc_red_sm) 		4 ILE A 224
SER A 220
ALA A  97
LYS A 168
 None
 0.95A 6dwnA-3hf1A:
undetectable		 6dwnA-3hf1A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A

(Saccharomyces
cerevisiae) 		no annotation 4 ILE C 333
SER C 332
ALA C 361
LEU C 388
 None
 0.83A 6dwnA-3j9uC:
undetectable		 6dwnA-3j9uC:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k25 SLR1438 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF01263
(Aldose_epim) 		4 ILE A 213
SER A 214
ALA A 178
LEU A 253
 None
 1.04A 6dwnA-3k25A:
undetectable		 6dwnA-3k25A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kz3 REPRESSOR PROTEIN CI

(Escherichia
virus Lambda) 		PF01381
(HTH_3) 		4 ILE A  79
SER A  78
ALA A  14
LEU A  64
 None
 1.08A 6dwnA-3kz3A:
undetectable		 6dwnA-3kz3A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS

(Streptomyces
sp. CK4412) 		PF00975
(Thioesterase) 		4 ILE A  61
SER A  89
ALA A 119
LEU A 145
 None
 0.93A 6dwnA-3lcrA:
undetectable		 6dwnA-3lcrA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		4 ILE A 957
SER A 958
ALA A 951
LEU A 944
 None
 1.01A 6dwnA-3lj0A:
undetectable		 6dwnA-3lj0A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndc PRECORRIN-4
C(11)-METHYLTRANSFER
ASE

(Rhodobacter
capsulatus) 		PF00590
(TP_methylase) 		4 ILE A  86
SER A  85
ALA A 114
LEU A 221
 SAH  A 300 (-4.9A)
None
None
SAH  A 300 (-4.4A)
 0.83A 6dwnA-3ndcA:
undetectable		 6dwnA-3ndcA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nk7 23S RRNA
METHYLTRANSFERASE

(Streptomyces
actuosus) 		PF00588
(SpoU_methylase)
PF04705
(TSNR_N) 		4 ILE A 133
SER A 250
ALA A 139
LEU A 171
 None
 1.02A 6dwnA-3nk7A:
undetectable		 6dwnA-3nk7A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		4 ILE A 874
SER A 873
ALA A 373
LEU A 507
 None
 1.08A 6dwnA-3opyA:
undetectable		 6dwnA-3opyA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p24 BFT-3

(Bacteroides
fragilis) 		PF13583
(Reprolysin_4)
PF16376
(fragilysinNterm) 		4 ILE A 304
SER A 336
ALA A 239
LEU A  85
 None
 0.97A 6dwnA-3p24A:
undetectable		 6dwnA-3p24A:
9.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pm0 CYTOCHROME P450 1B1

(Homo sapiens) 		PF00067
(p450) 		4 SER A 127
ALA A 330
LEU A 509
LYS A 512
 BHF  A 800 ( 4.6A)
HEM  A 900 ( 3.4A)
BHF  A 800 (-4.7A)
None
 0.77A 6dwnA-3pm0A:
48.0		 6dwnA-3pm0A:
58.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rio PTSGHI OPERON
ANTITERMINATOR

(Bacillus
subtilis) 		PF00874
(PRD)
PF03123
(CAT_RBD) 		4 ILE A  77
SER A  78
ALA A 108
LEU A 150
 None
 1.03A 6dwnA-3rioA:
undetectable		 6dwnA-3rioA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8m ENOYL-ACP REDUCTASE

(Xanthomonas
oryzae) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		4 ILE A 289
ALA A 278
LEU A 376
LYS A  12
 None
 0.90A 6dwnA-3s8mA:
undetectable		 6dwnA-3s8mA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5i FERROUS IRON
TRANSPORT PROTEIN B

(Gallionella
capsiferriformans) 		PF02421
(FeoB_N) 		4 ILE A 137
SER A 132
ALA A 156
LEU A  82
 None
 1.06A 6dwnA-3w5iA:
undetectable		 6dwnA-3w5iA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo6 MEMBRANE PROTEIN
INSERTASE YIDC 2

(Bacillus
halodurans) 		PF02096
(60KD_IMP) 		4 ILE A  64
SER A  63
ALA A 152
LEU A 240
 None
 1.04A 6dwnA-3wo6A:
undetectable		 6dwnA-3wo6A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 ILE A 701
SER A 344
ALA A 650
LEU A 614
 None
 1.03A 6dwnA-4cakA:
undetectable		 6dwnA-4cakA:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 738
SER A 739
ALA A 747
LEU A 709
 None
 1.07A 6dwnA-4ckrA:
undetectable		 6dwnA-4ckrA:
15.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		5 ILE A 115
SER A 116
ALA A 317
LEU A 496
LYS A 499
 BHF  A 602 (-4.7A)
BHF  A 602 (-3.2A)
BHF  A 602 ( 3.4A)
None
None
 0.43A 6dwnA-4i8vA:
62.1		 6dwnA-4i8vA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4icq AMINOPEPTIDASE PEPS

(Streptococcus
pneumoniae) 		PF02073
(Peptidase_M29) 		4 ILE A 283
SER A 269
ALA A 350
LEU A 307
 None
None
ZN  A 501 ( 4.3A)
None
 1.04A 6dwnA-4icqA:
undetectable		 6dwnA-4icqA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knh NUP192P

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		4 ILE A 873
SER A 872
ALA A 863
LEU A 940
 None
 0.97A 6dwnA-4knhA:
undetectable		 6dwnA-4knhA:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgg MUCONATE LACTONIZING
ENZYME

(Labrenzia
aggregata) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 266
SER A 267
ALA A 108
LEU A 121
 None
 1.01A 6dwnA-4mggA:
undetectable		 6dwnA-4mggA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo sapiens) 		PF01728
(FtsJ) 		4 ILE A 342
SER A 343
ALA A 462
LEU A 385
 None
 0.93A 6dwnA-4n49A:
undetectable		 6dwnA-4n49A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN

(Bordetella
bronchiseptica) 		PF03480
(DctP) 		4 ILE A  51
SER A  50
ALA A 254
LEU A 248
 None
 0.98A 6dwnA-4nq8A:
undetectable		 6dwnA-4nq8A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okr MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii) 		PF00090
(TSP_1)
PF00092
(VWA) 		4 ILE A  87
SER A  84
ALA A 215
LEU A 252
 None
 1.06A 6dwnA-4okrA:
undetectable		 6dwnA-4okrA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3g SIGNAL RECOGNITION
PARTICLE SUBUNIT
SRP68

(Chaetomium
thermophilum) 		PF16969
(SRP68) 		4 ILE A  59
SER A 125
ALA A 135
LEU A  70
 None
 1.05A 6dwnA-4p3gA:
undetectable		 6dwnA-4p3gA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY

(Shewanella
oneidensis) 		PF07804
(HipA_C)
PF13657
(Couple_hipA) 		4 ILE A  95
SER A 147
ALA A 104
LEU A   9
 None
 1.02A 6dwnA-4pu5A:
undetectable		 6dwnA-4pu5A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmh LP04448P

(Drosophila
melanogaster) 		PF12348
(CLASP_N) 		4 ILE A 888
SER A 889
ALA A 922
LEU A 905
 None
 1.06A 6dwnA-4qmhA:
undetectable		 6dwnA-4qmhA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013) 		PF12697
(Abhydrolase_6) 		4 ILE A 271
SER A 272
ALA A  50
LEU A  54
 None
 0.74A 6dwnA-4rncA:
undetectable		 6dwnA-4rncA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rot ESTERASE A

(Streptococcus
pyogenes) 		PF00756
(Esterase) 		4 ILE A  22
SER A   3
ALA A  60
LEU A 243
 None
 0.94A 6dwnA-4rotA:
undetectable		 6dwnA-4rotA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqv ALGM2

(Sphingomonas
sp.) 		PF00528
(BPD_transp_1) 		4 ILE B 167
SER B 166
ALA B  99
LEU B 186
 None
 1.03A 6dwnA-4tqvB:
undetectable		 6dwnA-4tqvB:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjn NUCLEOCAPSID

(Mammalian
rubulavirus 5) 		PF00973
(Paramyxo_ncap) 		4 ILE A  58
SER A  61
ALA A 129
LEU A 114
 None
 1.06A 6dwnA-4xjnA:
undetectable		 6dwnA-4xjnA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xru RNL

(Capnocytophaga
gingivalis) 		PF16542
(PNKP_ligase) 		4 ILE B  69
SER B 119
ALA B  99
LEU B  75
 None
 0.96A 6dwnA-4xruB:
undetectable		 6dwnA-4xruB:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwx SHC-TRANSFORMING
PROTEIN 1

(Homo sapiens) 		PF00640
(PID) 		4 ILE A 150
SER A 149
ALA A 143
LEU A 124
 None
 1.06A 6dwnA-4xwxA:
undetectable		 6dwnA-4xwxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ab8 GROUP 1 TRUNCATED
HEMOGLOBIN GLBN

(Mycobacterium
tuberculosis) 		PF01152
(Bac_globin) 		4 ILE A  15
SER A  14
ALA A  24
LEU A 102
 None
 1.00A 6dwnA-5ab8A:
undetectable		 6dwnA-5ab8A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 ILE A 794
SER A 310
LEU A 800
LYS A 912
 None
 0.74A 6dwnA-5aw4A:
undetectable		 6dwnA-5aw4A:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ILE A 343
SER A 342
ALA A 242
LEU A  18
 None
 1.07A 6dwnA-5bp1A:
undetectable		 6dwnA-5bp1A:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cek TRIBBLES HOMOLOG 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 307
SER A 308
ALA A 183
LEU A 277
 None
 0.94A 6dwnA-5cekA:
undetectable		 6dwnA-5cekA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		4 ILE A1008
SER A 647
ALA A 885
LEU A 983
 None
 1.03A 6dwnA-5d0fA:
undetectable		 6dwnA-5d0fA:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3m ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2

(Lactobacillus
delbrueckii) 		PF00005
(ABC_tran) 		4 ILE B 167
SER B  88
ALA B 157
LEU B 187
 None
 0.97A 6dwnA-5d3mB:
undetectable		 6dwnA-5d3mB:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 ILE A1192
SER A1193
ALA A1180
LEU A1296
 None
 0.98A 6dwnA-5dotA:
undetectable		 6dwnA-5dotA:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		4 ILE B 873
SER B 872
ALA B 863
LEU B 940
 None
 0.88A 6dwnA-5hb4B:
undetectable		 6dwnA-5hb4B:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hos CELLULASE

(Xanthomonas
citri) 		PF00150
(Cellulase) 		4 ILE A 196
SER A 195
ALA A 150
LEU A 135
 None
 1.08A 6dwnA-5hosA:
undetectable		 6dwnA-5hosA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 ILE A 452
SER A 455
ALA A 506
LEU A 181
 None
 0.97A 6dwnA-5ikrA:
undetectable		 6dwnA-5ikrA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrj PROTEIN RECA

(Herbaspirillum
seropedicae) 		PF00154
(RecA) 		4 ILE A 100
SER A 124
ALA A 138
LEU A 185
 None
 1.03A 6dwnA-5jrjA:
undetectable		 6dwnA-5jrjA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens) 		no annotation 4 ILE A 311
SER A 180
ALA A 121
LEU A 281
 None
 0.92A 6dwnA-5mg5A:
undetectable		 6dwnA-5mg5A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkz UBIQUITIN-CONJUGATIN
G ENZYME E2-21 KDA

(Ogataea angusta) 		no annotation 4 ILE A  26
SER A  24
ALA A  14
LEU A  34
 None
 0.97A 6dwnA-5nkzA:
undetectable		 6dwnA-5nkzA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn7 URACIL-DNA
GLYCOSYLASE

(Human
gammaherpesvirus
8) 		no annotation 4 ILE A 115
SER A 114
ALA A 208
LEU A 185
 None
 0.95A 6dwnA-5nn7A:
undetectable		 6dwnA-5nn7A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		4 ILE A1591
SER A1590
ALA A1565
LEU A1616
 None
 0.92A 6dwnA-5t8vA:
undetectable		 6dwnA-5t8vA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uao TRYPTOPHANE-5-HALOGE
NASE

(Microbispora
sp. ATCC
PTA-5024) 		PF04820
(Trp_halogenase) 		4 ILE A 403
SER A 402
ALA A 455
LEU A 441
 None
 0.72A 6dwnA-5uaoA:
undetectable		 6dwnA-5uaoA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvg SPHINGOMYELIN
PHOSPHODIESTERASE
3,SPHINGOMYELIN
PHOSPHODIESTERASE 3

(Homo sapiens) 		no annotation 4 ILE A 630
SER A 350
ALA A 162
LEU A 360
 None
 0.91A 6dwnA-5uvgA:
undetectable		 6dwnA-5uvgA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		no annotation 4 ILE A 125
ALA A 166
LEU A 104
LYS A 324
 None
 0.96A 6dwnA-5wh6A:
undetectable		 6dwnA-5wh6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfm ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 ILE A 314
SER A 313
ALA A 334
LEU A 365
 None
 0.94A 6dwnA-5xfmA:
undetectable		 6dwnA-5xfmA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjj MULTI DRUG EFFLUX
TRANSPORTER

(Camelina sativa) 		PF01554
(MatE) 		4 ILE A 122
SER A 123
ALA A 161
LEU A  84
 None
 1.02A 6dwnA-5xjjA:
undetectable		 6dwnA-5xjjA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ams BETA SLIDING CLAMP

(Pseudomonas
aeruginosa) 		no annotation 4 ILE A 224
SER A 235
ALA A 205
LEU A 135
 None
 1.07A 6dwnA-6amsA:
undetectable		 6dwnA-6amsA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cza -

(-) 		no annotation 4 ILE A 387
SER A 388
ALA A 694
LEU A 672
 None
 0.93A 6dwnA-6czaA:
undetectable		 6dwnA-6czaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d9h CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1

(Homo sapiens) 		no annotation 4 ILE R 239
SER R 235
ALA R 289
LEU R  51
 None
 1.07A 6dwnA-6d9hR:
undetectable		 6dwnA-6d9hR:
21.65