SIMILAR PATTERNS OF AMINO ACIDS FOR 6DWD_C_GLYC713_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aq0 1,3-1,4-BETA-GLUCANA
SE


(Hordeum vulgare)
PF00332
(Glyco_hydro_17)
3 GLN A 299
TYR A 295
ASN A 297
None
1.03A 6dwdC-1aq0A:
0.0
6dwdC-1aq0A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1br2 MYOSIN

(Gallus gallus)
PF00063
(Myosin_head)
PF02736
(Myosin_N)
3 GLN A 361
TYR A 313
ASN A 364
None
0.86A 6dwdC-1br2A:
0.0
6dwdC-1br2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN


(Propionibacterium
freudenreichii)
PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
3 GLN A 110
TYR A 102
ASN A 105
None
0.91A 6dwdC-1e1cA:
0.0
6dwdC-1e1cA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE


(Sus scrofa)
PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21)
3 GLN A 852
TYR A 110
ASN A 108
None
1.08A 6dwdC-1h7wA:
0.0
6dwdC-1h7wA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i84 SMOOTH MUSCLE MYOSIN
HEAVY CHAIN


(Gallus gallus)
PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N)
3 GLN S 361
TYR S 313
ASN S 364
None
0.89A 6dwdC-1i84S:
0.0
6dwdC-1i84S:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkm BREFELDIN A ESTERASE

(Bacillus
subtilis)
PF07859
(Abhydrolase_3)
3 GLN A  72
TYR A  75
ASN A 136
None
0.97A 6dwdC-1jkmA:
0.0
6dwdC-1jkmA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxk ALPHA-AMYLASE,
SALIVARY


(Homo sapiens)
PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
3 GLN A 232
TYR A 247
ASN A 250
None
1.07A 6dwdC-1jxkA:
0.0
6dwdC-1jxkA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mi1 NEUROBEACHIN

(Homo sapiens)
PF02138
(Beach)
PF14844
(PH_BEACH)
3 GLN A2149
TYR A2210
ASN A2230
None
1.01A 6dwdC-1mi1A:
0.0
6dwdC-1mi1A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ose PORCINE
ALPHA-AMYLASE


(Sus scrofa)
PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
3 GLN A 232
TYR A 247
ASN A 250
None
1.01A 6dwdC-1oseA:
undetectable
6dwdC-1oseA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sbp SULFATE-BINDING
PROTEIN


(Salmonella
enterica)
PF13531
(SBP_bac_11)
3 GLN A  40
TYR A  17
ASN A  21
None
0.99A 6dwdC-1sbpA:
undetectable
6dwdC-1sbpA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thm THERMITASE

(Thermoactinomyces
vulgaris)
PF00082
(Peptidase_S8)
3 GLN A  19
TYR A 274
ASN A 272
None
0.98A 6dwdC-1thmA:
undetectable
6dwdC-1thmA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un1 XYLOGLUCAN
ENDOTRANSGLYCOSYLASE


(Populus tremula)
PF00722
(Glyco_hydro_16)
PF06955
(XET_C)
3 GLN A 115
TYR A 252
ASN A 251
None
1.02A 6dwdC-1un1A:
undetectable
6dwdC-1un1A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkg MAJOR MITE FECAL
ALLERGEN DER P 1


(Dermatophagoides
pteronyssinus)
PF00112
(Peptidase_C1)
3 GLN A 164
TYR A 196
ASN A 195
None
0.56A 6dwdC-1xkgA:
undetectable
6dwdC-1xkgA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjd T-CELL-SPECIFIC
SURFACE GLYCOPROTEIN
CD28


(Homo sapiens)
PF15910
(V-set_2)
3 GLN C  88
TYR C  85
ASN C  87
None
NAG  C 203 (-3.4A)
NAG  C 203 (-1.9A)
0.86A 6dwdC-1yjdC:
undetectable
6dwdC-1yjdC:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb0 IMIDAZOLONEPROPIONAS
E


(Bacillus
subtilis)
PF01979
(Amidohydro_1)
3 GLN A  14
TYR A 390
ASN A 389
None
1.06A 6dwdC-2bb0A:
undetectable
6dwdC-2bb0A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3d 2-OXOPROPYL-COM
REDUCTASE


(Xanthobacter
autotrophicus)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
3 GLN A 342
TYR A 340
ASN A 374
None
1.02A 6dwdC-2c3dA:
undetectable
6dwdC-2c3dA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cnm MODIFICATION OF 30S
RIBOSOMAL SUBUNIT
PROTEIN S18


(Salmonella
enterica)
PF00583
(Acetyltransf_1)
3 GLN A  36
TYR A  40
ASN A  42
None
1.01A 6dwdC-2cnmA:
undetectable
6dwdC-2cnmA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eaa 7S GLOBULIN-3

(Vigna angularis)
PF00190
(Cupin_1)
3 GLN A  37
TYR A  38
ASN A  36
None
0.94A 6dwdC-2eaaA:
undetectable
6dwdC-2eaaA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgq OUTER MEMBRANE PORIN
PROTEIN 32


(Delftia
acidovorans)
PF13609
(Porin_4)
3 GLN X 325
TYR X 289
ASN X 291
None
0.97A 6dwdC-2fgqX:
undetectable
6dwdC-2fgqX:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho1 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILF


(Pseudomonas
aeruginosa)
PF13414
(TPR_11)
PF13424
(TPR_12)
3 GLN A  55
TYR A  47
ASN A  52
None
0.97A 6dwdC-2ho1A:
undetectable
6dwdC-2ho1A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqf CATALASE

(Helicobacter
pylori)
PF00199
(Catalase)
PF06628
(Catalase-rel)
3 GLN A 353
TYR A 376
ASN A 374
MHO  A 372 ( 4.7A)
None
None
1.05A 6dwdC-2iqfA:
undetectable
6dwdC-2iqfA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc4 EXODEOXYRIBONUCLEASE
III


(Neisseria
meningitidis)
PF03372
(Exo_endo_phos)
3 GLN A  59
TYR A  62
ASN A  63
None
2HP  A1261 ( 4.0A)
None
0.56A 6dwdC-2jc4A:
undetectable
6dwdC-2jc4A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6q VARIABLE LYMPHOCYTE
RECEPTOR A


(Eptatretus
burgeri)
PF13855
(LRR_8)
3 GLN A  67
TYR A  89
ASN A  91
None
1.00A 6dwdC-2o6qA:
undetectable
6dwdC-2o6qA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxy ALIPHATIC AMIDASE

(Pseudomonas
aeruginosa)
PF00795
(CN_hydrolase)
3 GLN A 190
TYR A 192
ASN A 219
C3Y  A 166 ( 4.8A)
C3Y  A 166 ( 3.3A)
None
1.00A 6dwdC-2uxyA:
undetectable
6dwdC-2uxyA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsa MOSQUITOCIDAL TOXIN

(Lysinibacillus
sphaericus)
PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2)
3 GLN A 857
TYR A 852
ASN A 854
None
0.72A 6dwdC-2vsaA:
undetectable
6dwdC-2vsaA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL


(Homo sapiens)
PF00155
(Aminotran_1_2)
3 GLN A 237
TYR A 234
ASN A 199
None
0.68A 6dwdC-2xh1A:
undetectable
6dwdC-2xh1A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y24 XYLANASE

(Dickeya
chrysanthemi)
PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C)
3 GLN A  42
TYR A  41
ASN A 282
None
0.98A 6dwdC-2y24A:
undetectable
6dwdC-2y24A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA


(Homo sapiens)
PF01504
(PIP5K)
3 GLN A  32
TYR A  30
ASN A  83
None
0.98A 6dwdC-2ybxA:
undetectable
6dwdC-2ybxA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn7 OUTER SURFACE
PROTEIN


(Borreliella
burgdorferi)
PF05714
(Borrelia_lipo_1)
3 GLN A 364
TYR A 392
ASN A 395
None
0.90A 6dwdC-2yn7A:
undetectable
6dwdC-2yn7A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE


(Photobacterium
sp. JT-ISH-224)
PF11477
(PM0188)
3 GLN A 346
TYR A 349
ASN A 350
None
0.99A 6dwdC-2z4tA:
undetectable
6dwdC-2z4tA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9s D-ARABINOSE
ISOMERASE


(Aeribacillus
pallidus)
PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2)
3 GLN A  56
TYR A  52
ASN A  54
None
1.04A 6dwdC-3a9sA:
undetectable
6dwdC-3a9sA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkh LYTIC
TRANSGLYCOSYLASE


(Pseudomonas
virus phiKZ)
PF01464
(SLT)
PF01471
(PG_binding_1)
3 GLN A 245
TYR A 248
ASN A 249
None
1.04A 6dwdC-3bkhA:
undetectable
6dwdC-3bkhA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwq CAPSID PROTEIN VP1

(Macaca mulatta
polyomavirus 1)
PF00718
(Polyoma_coat)
3 GLN A 187
TYR A 168
ASN A 167
None
0.99A 6dwdC-3bwqA:
undetectable
6dwdC-3bwqA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes)
PF12799
(LRR_4)
3 GLN A 356
TYR A 375
ASN A 377
None
0.93A 6dwdC-3bz5A:
undetectable
6dwdC-3bz5A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5i CHOLINE KINASE

(Plasmodium
knowlesi)
PF01633
(Choline_kinase)
3 GLN A 220
TYR A 259
ASN A 222
CHT  A1001 (-3.2A)
CHT  A1001 ( 4.6A)
MG  A 370 ( 4.4A)
0.99A 6dwdC-3c5iA:
undetectable
6dwdC-3c5iA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clw CONSERVED EXPORTED
PROTEIN


(Bacteroides
fragilis)
PF14587
(Glyco_hydr_30_2)
3 GLN A  40
TYR A  39
ASN A 373
None
1.05A 6dwdC-3clwA:
undetectable
6dwdC-3clwA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cym UNCHARACTERIZED
PROTEIN BAD_0989


(Bifidobacterium
adolescentis)
PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1)
3 GLN A 412
TYR A 390
ASN A 393
None
1.04A 6dwdC-3cymA:
undetectable
6dwdC-3cymA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6s ALLERGEN DER F I

(Dermatophagoides
farinae)
PF00112
(Peptidase_C1)
3 GLN A  85
TYR A 117
ASN A 116
None
0.70A 6dwdC-3d6sA:
undetectable
6dwdC-3d6sA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 3
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 2


(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe)
PF00022
(Actin)
PF04045
(P34-Arc)
3 GLN D  29
TYR A  21
ASN A  24
None
1.01A 6dwdC-3dwlD:
undetectable
6dwdC-3dwlD:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e53 FATTY-ACID-COA
LIGASE FADD28


(Mycobacterium
tuberculosis)
PF00501
(AMP-binding)
3 GLN A 194
TYR A 337
ASN A 191
None
0.91A 6dwdC-3e53A:
undetectable
6dwdC-3e53A:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqa GLUCOAMYLASE

(Aspergillus
niger)
PF00723
(Glyco_hydro_15)
3 GLN A 425
TYR A 336
ASN A 339
None
1.07A 6dwdC-3eqaA:
undetectable
6dwdC-3eqaA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7n NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae)
PF11715
(Nup160)
3 GLN A 104
TYR A 106
ASN A 103
None
1.02A 6dwdC-3h7nA:
undetectable
6dwdC-3h7nA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbu SECRETED PROTEASE C

(Dickeya
chrysanthemi)
PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C)
3 GLN P 313
TYR P 309
ASN P 311
None
1.07A 6dwdC-3hbuP:
undetectable
6dwdC-3hbuP:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3io0 ETUB PROTEIN

(Clostridium
kluyveri)
PF00936
(BMC)
3 GLN A 199
TYR A 184
ASN A 187
None
0.95A 6dwdC-3io0A:
undetectable
6dwdC-3io0A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4p CAPSID PROTEIN VP1

(Adeno-associated
virus)
PF00740
(Parvo_coat)
3 GLN A 299
TYR A 702
ASN A 303
None
1.05A 6dwdC-3j4pA:
undetectable
6dwdC-3j4pA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr1 PUTATIVE
FRUCTOSAMINE-3-KINAS
E


(Histophilus
somni)
PF03881
(Fructosamin_kin)
3 GLN A 156
TYR A 267
ASN A 264
None
0.81A 6dwdC-3jr1A:
undetectable
6dwdC-3jr1A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm8 THIAMINE
PYROPHOSPHOKINASE


(Bacillus
subtilis)
PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding)
3 GLN A  98
TYR A  21
ASN A   5
None
1.05A 6dwdC-3lm8A:
undetectable
6dwdC-3lm8A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng9 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A)
PF00740
(Parvo_coat)
3 GLN A 298
TYR A 701
ASN A 302
None
1.00A 6dwdC-3ng9A:
undetectable
6dwdC-3ng9A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwn KINESIN-LIKE PROTEIN
KIF9


(Homo sapiens)
PF00225
(Kinesin)
3 GLN A  80
TYR A  85
ASN A 310
None
0.97A 6dwdC-3nwnA:
undetectable
6dwdC-3nwnA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1


(Saccharomyces
cerevisiae)
PF01399
(PCI)
3 GLN B 235
TYR B 230
ASN B 233
None
0.89A 6dwdC-3t5vB:
undetectable
6dwdC-3t5vB:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux1 CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A)
PF00740
(Parvo_coat)
3 GLN A 299
TYR A 701
ASN A 303
None
1.06A 6dwdC-3ux1A:
undetectable
6dwdC-3ux1A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8h THYMIDYLATE SYNTHASE

(Burkholderia
thailandensis)
PF00303
(Thymidylat_synt)
3 GLN A 260
TYR A 257
ASN A 259
None
CIT  A 400 (-4.5A)
None
1.01A 6dwdC-3v8hA:
undetectable
6dwdC-3v8hA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq4 BETA-PRIMEVEROSIDASE

(Camellia
sinensis)
PF00232
(Glyco_hydro_1)
3 GLN A 371
TYR A 275
ASN A 348
None
0.87A 6dwdC-3wq4A:
undetectable
6dwdC-3wq4A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum)
PF00703
(Glyco_hydro_2)
3 GLN A  85
TYR A  44
ASN A  42
None
NAG  A1972 ( 4.8A)
None
0.93A 6dwdC-4cvuA:
undetectable
6dwdC-4cvuA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 3


(Homo sapiens)
PF01399
(PCI)
3 GLN C 132
TYR C 161
ASN C 136
None
0.97A 6dwdC-4d10C:
undetectable
6dwdC-4d10C:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffb PROTEIN STU2

(Saccharomyces
cerevisiae)
no annotation 3 GLN C 202
TYR C 164
ASN C 161
None
0.94A 6dwdC-4ffbC:
undetectable
6dwdC-4ffbC:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fuu LEUCINE
AMINOPEPTIDASE


(Bacteroides
thetaiotaomicron)
PF04389
(Peptidase_M28)
3 GLN A  90
TYR A 204
ASN A 106
None
1.00A 6dwdC-4fuuA:
undetectable
6dwdC-4fuuA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h32 HEMAGGLUTININ

(Influenza A
virus)
PF00509
(Hemagglutinin)
3 GLN A 188
TYR A 192
ASN A 194
None
0.69A 6dwdC-4h32A:
undetectable
6dwdC-4h32A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcd MAJOR CAPSID PROTEIN
VP1


(Human
polyomavirus 2)
PF00718
(Polyoma_coat)
3 GLN A 179
TYR A 160
ASN A 159
None
0.91A 6dwdC-4jcdA:
undetectable
6dwdC-4jcdA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP


(Aspergillus
fumigatus)
PF02128
(Peptidase_M36)
3 GLN A 298
TYR A 307
ASN A 383
None
1.07A 6dwdC-4k90A:
undetectable
6dwdC-4k90A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbx UNCHARACTERIZED
PROTEIN YHFX


(Escherichia
coli)
PF01168
(Ala_racemase_N)
3 GLN A 230
TYR A  57
ASN A 232
None
1.06A 6dwdC-4kbxA:
undetectable
6dwdC-4kbxA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lf0 ALIPHATIC AMIDASE

(Bacillus sp.
(in: Bacteria))
PF00795
(CN_hydrolase)
3 GLN A 190
TYR A 192
ASN A 219
None
1.01A 6dwdC-4lf0A:
undetectable
6dwdC-4lf0A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lql L-ARABINOSE
ISOMERASE


(Lactobacillus
fermentum)
PF02610
(Arabinose_Isome)
PF11762
(Arabinose_Iso_C)
3 GLN A 125
TYR A  19
ASN A 122
None
0.88A 6dwdC-4lqlA:
undetectable
6dwdC-4lqlA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mae METHANOL
DEHYDROGENASE


(Methylacidiphilum
fumariolicum)
PF13360
(PQQ_2)
3 GLN A  95
TYR A  71
ASN A  73
None
1.06A 6dwdC-4maeA:
undetectable
6dwdC-4maeA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mj0 VP1 CAPSID PROTEIN

(Human
polyomavirus 1)
PF00718
(Polyoma_coat)
3 GLN A 187
TYR A 168
ASN A 167
None
0.91A 6dwdC-4mj0A:
undetectable
6dwdC-4mj0A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtk VGRG1

(Pseudomonas
aeruginosa)
PF05954
(Phage_GPD)
3 GLN A 466
TYR A 458
ASN A 463
None
0.99A 6dwdC-4mtkA:
undetectable
6dwdC-4mtkA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npr XYLOGLUCAN-SPECIFIC
ENDO-BETA-1,4-GLUCAN
ASE GH12


(Aspergillus
niveus)
PF01670
(Glyco_hydro_12)
3 GLN A 215
TYR A  37
ASN A  83
None
1.04A 6dwdC-4nprA:
undetectable
6dwdC-4nprA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxq D-GLUCURONYL C5
EPIMERASE B


(Danio rerio)
PF06662
(C5-epim_C)
3 GLN A 555
TYR A 131
ASN A 552
None
0.88A 6dwdC-4pxqA:
undetectable
6dwdC-4pxqA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbj GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE


(Aspergillus
fumigatus)
PF01233
(NMT)
PF02799
(NMT_C)
3 GLN A 245
TYR A 244
ASN A 463
None
0.82A 6dwdC-4qbjA:
undetectable
6dwdC-4qbjA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN


(Lactococcus
phage 1358)
no annotation 3 GLN A  27
TYR A 182
ASN A 179
None
0.91A 6dwdC-4rggA:
undetectable
6dwdC-4rggA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rso CAPSID PROTEIN VP1

(Non-human
primate
Adeno-associated
virus)
PF00740
(Parvo_coat)
3 GLN A 299
TYR A 701
ASN A 303
None
0.95A 6dwdC-4rsoA:
undetectable
6dwdC-4rsoA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trq NUCLEAR MRNA EXPORT
PROTEIN THP1


(Saccharomyces
cerevisiae)
PF01399
(PCI)
3 GLN B 235
TYR B 230
ASN B 233
None
0.93A 6dwdC-4trqB:
undetectable
6dwdC-4trqB:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tu3 PHOSPHOINOSITIDE
PHOSPHATASE SAC1


(Saccharomyces
cerevisiae)
PF02383
(Syja_N)
3 GLN X 292
TYR X 296
ASN X 299
None
1.04A 6dwdC-4tu3X:
undetectable
6dwdC-4tu3X:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u60 STRUCTURAL PROTEIN
VP1


(Human
polyomavirus 8)
PF00718
(Polyoma_coat)
3 GLN A 193
TYR A 172
ASN A 171
None
0.96A 6dwdC-4u60A:
undetectable
6dwdC-4u60A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae)
no annotation 3 GLN E 104
TYR E 106
ASN E 103
None
0.91A 6dwdC-4xmmE:
undetectable
6dwdC-4xmmE:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N)
3 GLN A1130
TYR A1149
ASN A1151
None
1.02A 6dwdC-4zktA:
undetectable
6dwdC-4zktA:
17.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ao0 DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1


(Homo sapiens)
PF01966
(HD)
3 GLN A 447
TYR A 450
ASN A 452
None
0.37A 6dwdC-5ao0A:
49.5
6dwdC-5ao0A:
85.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3l NUCLEOPORIN NUP58
NANOBODY NB15


(Xenopus laevis;
Camelus
dromedarius)
PF15967
(Nucleoporin_FG2)
PF07686
(V-set)
3 GLN B 363
TYR D 100
ASN D  98
None
1.05A 6dwdC-5c3lB:
undetectable
6dwdC-5c3lB:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cer BD0816
BD3460


(Bdellovibrio
bacteriovorus;
Bdellovibrio
bacteriovorus)
PF02113
(Peptidase_S13)
PF12796
(Ank_2)
3 GLN A 396
TYR B 174
ASN A 399
None
1.02A 6dwdC-5cerA:
undetectable
6dwdC-5cerA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ev7 CONSERVED DOMAIN
PROTEIN


(Bacillus
anthracis)
PF13402
(Peptidase_M60)
PF17291
(M60-like_N)
3 GLN A 367
TYR A 448
ASN A 364
None
1.03A 6dwdC-5ev7A:
undetectable
6dwdC-5ev7A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fly FERRICHROME-BINDING
PERIPLASMIC PROTEIN


(Staphylococcus
pseudintermedius)
PF01497
(Peripla_BP_2)
3 GLN A 184
TYR A 113
ASN A 174
None
0.96A 6dwdC-5flyA:
undetectable
6dwdC-5flyA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp1 TONB-DEPENDENT
SIDEROPHORE RECEPTOR


(Acinetobacter
baumannii)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
3 GLN A 607
TYR A 610
ASN A 595
None
1.02A 6dwdC-5fp1A:
undetectable
6dwdC-5fp1A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN


(Bacteroides
thetaiotaomicron)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
3 GLN B 276
TYR B 255
ASN B 257
None
0.96A 6dwdC-5fq6B:
undetectable
6dwdC-5fq6B:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv0 ESSC

(Geobacillus
thermodenitrificans)
PF01580
(FtsK_SpoIIIE)
3 GLN A1026
TYR A1022
ASN A1023
None
1.02A 6dwdC-5fv0A:
undetectable
6dwdC-5fv0A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs2 REPEBODY
ANTI-REPEBODY


(Escherichia
coli;
Mus musculus)
PF11921
(DUF3439)
PF12354
(Internalin_N)
PF13855
(LRR_8)
PF07686
(V-set)
3 GLN B 192
TYR D  54
ASN D  52
None
0.78A 6dwdC-5gs2B:
undetectable
6dwdC-5gs2B:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7)
PF00704
(Glyco_hydro_18)
3 GLN B 514
TYR B 506
ASN B 511
None
0.78A 6dwdC-5gztB:
undetectable
6dwdC-5gztB:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izt OUTER SURFACE
PROTEIN


(Borreliella
burgdorferi)
PF05714
(Borrelia_lipo_1)
3 GLN A 364
TYR A 392
ASN A 395
None
0.89A 6dwdC-5iztA:
undetectable
6dwdC-5iztA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfn CHONDROADHERIN

(Homo sapiens)
PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8)
3 GLN A 153
TYR A 177
ASN A 155
None
0.80A 6dwdC-5lfnA:
undetectable
6dwdC-5lfnA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3h POLYMERASE ACIDIC
PROTEIN


(Influenza A
virus)
PF00603
(Flu_PA)
3 GLN A 212
TYR A 226
ASN A 216
None
1.07A 6dwdC-5m3hA:
undetectable
6dwdC-5m3hA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mc9 LAMININ SUBUNIT
BETA-1
LAMININ SUBUNIT
GAMMA-1


(Mus musculus;
Mus musculus)
no annotation
no annotation
3 GLN C1566
TYR B1747
ASN B1750
None
1.06A 6dwdC-5mc9C:
undetectable
6dwdC-5mc9C:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nb8 PROTEIN NOV HOMOLOG

(Rattus
norvegicus)
PF00093
(VWC)
3 GLN A 122
TYR A 123
ASN A 120
None
0.99A 6dwdC-5nb8A:
undetectable
6dwdC-5nb8A:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum)
PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127)
3 GLN A 616
TYR A 635
ASN A 632
None
0.67A 6dwdC-5o0sA:
undetectable
6dwdC-5o0sA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgf UNCHARACTERIZED
PROTEIN


(Bacteroides
dorei)
PF00144
(Beta-lactamase)
3 GLN A 283
TYR A 282
ASN A 297
None
1.00A 6dwdC-5tgfA:
undetectable
6dwdC-5tgfA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vh2 CADHERIN-23

(Mus musculus)
no annotation 3 GLN A1189
TYR A1277
ASN A1191
None
1.06A 6dwdC-5vh2A:
undetectable
6dwdC-5vh2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4b ADENOSYLHOMOCYSTEINA
SE


(Homo sapiens)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
3 GLN A 251
TYR A 221
ASN A 248
None
None
NAD  A 501 (-3.2A)
1.05A 6dwdC-5w4bA:
undetectable
6dwdC-5w4bA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzr ALPHA-N-ACETYLGALACT
OSAMINIDASE


(Bifidobacterium
bifidum)
PF11308
(Glyco_hydro_129)
3 GLN A 136
TYR A 515
ASN A 516
None
1.04A 6dwdC-5wzrA:
undetectable
6dwdC-5wzrA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykh PUMILIO HOMOLOG 1

(Homo sapiens)
no annotation 3 GLN A 227
TYR A 224
ASN A 223
None
0.68A 6dwdC-5ykhA:
undetectable
6dwdC-5ykhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 8


(Ficedula
albicollis)
no annotation 3 GLN A 173
TYR A 170
ASN A 199
None
0.92A 6dwdC-6bpqA:
undetectable
6dwdC-6bpqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehs HYDROGENASE-2 LARGE
CHAIN


(Escherichia
coli)
no annotation 3 GLN L 442
TYR L  90
ASN L  93
None
0.76A 6dwdC-6ehsL:
undetectable
6dwdC-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eks SIALIDASE

(Vibrio cholerae)
no annotation 3 GLN A 677
TYR A 673
ASN A 695
None
0.86A 6dwdC-6eksA:
undetectable
6dwdC-6eksA:
20.71