SIMILAR PATTERNS OF AMINO ACIDS FOR 6DWD_A_GLYA717_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b2i | PROTEIN(PLASMINOGEN) (Homo sapiens) |
PF00051(Kringle) | 4 | SER A -3ASP A 10ARG A 52LYS A 47 | None | 1.39A | 6dwdA-1b2iA:undetectable | 6dwdA-1b2iA:10.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b5f | PROTEIN (CARDOSIN A) (Cynaracardunculus) |
PF00026(Asp) | 4 | SER A 13ARG A 115ASP A 9ARG A 10 | None | 1.20A | 6dwdA-1b5fA:0.0 | 6dwdA-1b5fA:18.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c3e | GLYCINAMIDERIBONUCLEOTIDETRANSFORMYLASE (Escherichiacoli) |
PF00551(Formyl_trans_N) | 4 | SER A 93ARG A 64ASP A 68ARG A 90 | NoneNHR A 220 (-3.1A)NoneNone | 1.17A | 6dwdA-1c3eA:0.0 | 6dwdA-1c3eA:16.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hyb | NICOTINAMIDEMONONUCLEOTIDEADENYLYLTRANSFERASE (Methanothermobacterthermautotrophicus) |
PF01467(CTP_transf_like) | 4 | SER A 45ARG A 136ASP A 48ARG A 11 | NoneSO4 A1759 (-3.1A)NoneSO4 A1759 ( 3.2A) | 1.28A | 6dwdA-1hybA:0.0 | 6dwdA-1hybA:16.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qgr | PROTEIN (IMPORTINBETA SUBUNIT)PROTEIN (IMPORTINALPHA-2 SUBUNIT) (Homo sapiens;Homo sapiens) |
PF03810(IBN_N)PF13513(HEAT_EZ)PF01749(IBB) | 4 | SER A 633ASP A 676ARG B 39LYS B 42 | None | 1.19A | 6dwdA-1qgrA:0.0 | 6dwdA-1qgrA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wde | PROBABLE DIPHTHINESYNTHASE (Aeropyrumpernix) |
PF00590(TP_methylase) | 4 | SER A 66ARG A 68ASP A 69ARG A 73 | None | 0.99A | 6dwdA-1wdeA:undetectable | 6dwdA-1wdeA:18.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wmr | ISOPULLULANASE (Aspergillusniger) |
PF03718(Glyco_hydro_49)PF17433(Glyco_hydro_49N) | 4 | SER A 182ASP A 341ARG A 153LYS A 343 | None | 1.46A | 6dwdA-1wmrA:undetectable | 6dwdA-1wmrA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2an2 | P332G A333S DOUBLEMUTANT OF NITRICOXIDE SYNTHASE FROMBACILLUS SUBTILIS (Bacillussubtilis) |
PF02898(NO_synthase) | 4 | SER A 144ARG A 128ASP A 141ARG A 250 | NoneARG A2000 (-4.0A)NoneNone | 1.27A | 6dwdA-2an2A:undetectable | 6dwdA-2an2A:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c1c | CARBOXYPEPTIDASE B (Helicoverpa zea) |
PF00246(Peptidase_M14) | 4 | SER A 53ASP A 104ARG A 188LYS A 59 | None | 1.47A | 6dwdA-2c1cA:undetectable | 6dwdA-2c1cA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dw4 | LYSINE-SPECIFICHISTONE DEMETHYLASE1 (Homo sapiens) |
PF01593(Amino_oxidase)PF04433(SWIRM) | 4 | SER A 522ARG A 524ASP A 525LYS A 374 | None | 1.28A | 6dwdA-2dw4A:undetectable | 6dwdA-2dw4A:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nli | LACTATE OXIDASE (Aerococcusviridans) |
PF01070(FMN_dh) | 4 | SER A 223ARG A 225ASP A 226LYS A 219 | None | 1.45A | 6dwdA-2nliA:undetectable | 6dwdA-2nliA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y3a | PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE3-KINASE CATALYTICSUBUNIT BETA ISOFORM (Mus musculus) |
PF00454(PI3_PI4_kinase)PF00613(PI3Ka)PF00792(PI3K_C2)PF00794(PI3K_rbd)PF02192(PI3K_p85B) | 4 | SER A 542ARG A 538ASP A 539LYS A1019 | None | 1.40A | 6dwdA-2y3aA:undetectable | 6dwdA-2y3aA:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bbj | PUTATIVETHIOESTERASE II (Thermobifidafusca) |
PF13622(4HBT_3) | 4 | SER A 180ARG A 182ASP A 183ARG A 149 | None | 1.26A | 6dwdA-3bbjA:undetectable | 6dwdA-3bbjA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3htk | E3 SUMO-PROTEINLIGASE MMS21 (Saccharomycescerevisiae) |
PF11789(zf-Nse) | 4 | SER C 231ARG C 233ASP C 234LYS C 199 | None | 1.26A | 6dwdA-3htkC:undetectable | 6dwdA-3htkC:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3htk | E3 SUMO-PROTEINLIGASE MMS21 (Saccharomycescerevisiae) |
PF11789(zf-Nse) | 4 | SER C 231ASP C 234ARG C 198LYS C 199 | None | 1.41A | 6dwdA-3htkC:undetectable | 6dwdA-3htkC:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iah | SHORT CHAINDEHYDROGENASE YCIK (Salmonellaenterica) |
PF00106(adh_short) | 4 | SER A 142ARG A 13ASP A 143ARG A 234 | None | 1.34A | 6dwdA-3iahA:undetectable | 6dwdA-3iahA:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m7k | RESTRICTIONENDONUCLEASE PACI (Pseudomonasalcaligenes) |
no annotation | 4 | SER A 94ARG A 106ASP A 92LYS A 116 | NoneNone MG A 145 (-3.4A) MG A 145 ( 4.2A) | 1.26A | 6dwdA-3m7kA:undetectable | 6dwdA-3m7kA:12.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3obi | FORMYLTETRAHYDROFOLATE DEFORMYLASE (Rhodopseudomonaspalustris) |
PF00551(Formyl_trans_N) | 4 | SER A 243ARG A 245ASP A 246LYS A 254 | None | 0.93A | 6dwdA-3obiA:undetectable | 6dwdA-3obiA:18.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hqp | ALPHA7 NICOTINICRECEPTOR CHIMERA (Lymnaeastagnalis;Homo sapiens) |
PF02931(Neur_chan_LBD) | 4 | SER A 180ARG A 182ASP A 193LYS A 141 | None | 1.44A | 6dwdA-4hqpA:undetectable | 6dwdA-4hqpA:17.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i4z | NAPHTHOATE SYNTHASE (Synechocystissp. PCC 6803) |
PF00378(ECH_1) | 4 | SER A 80ASP A 78ARG A 27LYS A 30 | 2NE A 301 ( 4.9A)2NE A 301 (-4.0A)None2NE A 301 (-4.5A) | 1.33A | 6dwdA-4i4zA:undetectable | 6dwdA-4i4zA:18.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n75 | OUTER MEMBRANEPROTEIN ASSEMBLYFACTOR BAMA (Escherichiacoli) |
PF01103(Bac_surface_Ag) | 4 | SER A 715ARG A 632ASP A 740ARG A 661 | None | 1.50A | 6dwdA-4n75A:undetectable | 6dwdA-4n75A:21.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4zwe | DEOXYNUCLEOSIDETRIPHOSPHATETRIPHOSPHOHYDROLASESAMHD1 (Homo sapiens) |
PF01966(HD) | 5 | SER A 192ARG A 194ASP A 195ARG A 290LYS A 294 | None | 0.26A | 6dwdA-4zweA:56.0 | 6dwdA-4zweA:99.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ao0 | DEOXYNUCLEOSIDETRIPHOSPHATETRIPHOSPHOHYDROLASESAMHD1 (Homo sapiens) |
PF01966(HD) | 5 | SER A 192ARG A 194ASP A 195ARG A 290LYS A 294 | None | 0.41A | 6dwdA-5ao0A:52.0 | 6dwdA-5ao0A:85.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b57 | HEMIN IMPORTATP-BINDING PROTEINHMUV (Burkholderiacenocepacia) |
PF00005(ABC_tran) | 4 | SER C 119ARG C 121ASP C 122ARG C 108 | None | 1.49A | 6dwdA-5b57C:undetectable | 6dwdA-5b57C:18.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jk6 | PHENYLALANINE-4-HYDROXYLASE (Dictyosteliumdiscoideum) |
PF00351(Biopterin_H) | 4 | SER A 20ARG A 111ASP A 69ARG A 51 | None | 1.21A | 6dwdA-5jk6A:undetectable | 6dwdA-5jk6A:24.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mqo | NON-REDUCING ENDBETA-L-ARABINOFURANOSIDASE (Bacteroidesthetaiotaomicron) |
PF07944(Glyco_hydro_127) | 4 | ARG A 292ASP A 329ARG A 333LYS A 334 | None | 1.24A | 6dwdA-5mqoA:undetectable | 6dwdA-5mqoA:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z9a | CHORISMATE SYNTHASE (Pseudomonasaeruginosa) |
no annotation | 4 | SER A 37ARG A 39ASP A 40LYS A 143 | None | 1.20A | 6dwdA-5z9aA:undetectable | 6dwdA-5z9aA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6brk | DEOXYNUCLEOSIDETRIPHOSPHATETRIPHOSPHOHYDROLASESAMHD1 (Mus musculus) |
no annotation | 5 | SER A 224ARG A 226ASP A 227ARG A 322LYS A 326 | None | 0.38A | 6dwdA-6brkA:52.2 | 6dwdA-6brkA:undetectable |