SIMILAR PATTERNS OF AMINO ACIDS FOR 6DRZ_A_H8JA1206_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aq0 1,3-1,4-BETA-GLUCANA
SE

(Hordeum vulgare) 		PF00332
(Glyco_hydro_17) 		5 VAL A 230
SER A 231
PHE A 207
GLY A 234
VAL A 127
 None
 1.11A 6drzA-1aq0A:
undetectable		 6drzA-1aq0A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bey CAMPATH-1H ANTIBODY

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 215
THR H 213
VAL H 219
GLY H 126
VAL H 160
 None
 0.91A 6drzA-1beyH:
undetectable		 6drzA-1beyH:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqq TYPE 2 RHINOVIRUS 3C
PROTEASE

(Rhinovirus A) 		PF00548
(Peptidase_C3) 		5 VAL A 150
LEU A 174
GLY A   7
VAL A 119
TYR A 138
 None
 1.16A 6drzA-1cqqA:
undetectable		 6drzA-1cqqA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hci ALPHA-ACTININ 2

(Homo sapiens) 		PF00435
(Spectrin) 		5 VAL A 614
LEU A 565
PHE A 561
GLY A 534
PHE A 528
 None
 1.13A 6drzA-1hciA:
2.3		 6drzA-1hciA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihp PHYTASE

(Aspergillus
ficuum) 		PF00328
(His_Phos_2) 		5 VAL A 408
VAL A  55
LEU A 384
GLY A 371
ASN A 404
 None
 1.11A 6drzA-1ihpA:
undetectable		 6drzA-1ihpA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rz8 FAB 17B HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL B 207
THR B 205
VAL B 211
GLY B 118
VAL B 152
 None
 1.00A 6drzA-1rz8B:
undetectable		 6drzA-1rz8B:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzf FAB E51 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 207
THR H 205
VAL H 211
GLY H 118
VAL H 152
 GOL  H9007 ( 4.9A)
None
None
None
None
 1.05A 6drzA-1rzfH:
undetectable		 6drzA-1rzfH:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ska 3-PHYTASE A

(Aspergillus
fumigatus) 		PF00328
(His_Phos_2) 		5 VAL A  76
VAL A 234
LEU A 237
PHE A 258
PHE A  86
 None
 1.04A 6drzA-1skaA:
0.0		 6drzA-1skaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ska 3-PHYTASE A

(Aspergillus
fumigatus) 		PF00328
(His_Phos_2) 		5 VAL A  76
VAL A 234
PHE A 258
PHE A  86
VAL A 227
 None
 1.05A 6drzA-1skaA:
0.0		 6drzA-1skaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u79 FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
3

(Arabidopsis
thaliana) 		PF00254
(FKBP_C) 		5 VAL A  66
LEU A  57
GLY A  73
PHE A 121
TYR A  99
 None
 1.15A 6drzA-1u79A:
undetectable		 6drzA-1u79A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT

(Mycobacterium
tuberculosis) 		PF00268
(Ribonuc_red_sm) 		5 VAL A 143
SER A 146
LEU A 166
GLY A  79
TYR A 226
 None
 1.03A 6drzA-1uzrA:
2.8		 6drzA-1uzrA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG

(Homo sapiens) 		PF08423
(Rad51) 		5 SER A 136
THR A 138
LEU A 303
PHE A 328
GLY A 334
 None
 1.11A 6drzA-1v5wA:
undetectable		 6drzA-1v5wA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 VAL A 688
VAL A 724
LEU A 723
GLY A 633
TYR A 661
 None
 1.15A 6drzA-2bucA:
undetectable		 6drzA-2bucA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyg BETA-1, 3-GLUCANANSE

(Musa acuminata) 		PF00332
(Glyco_hydro_17) 		5 VAL A 262
SER A 263
PHE A 239
GLY A 266
VAL A 159
 None
 1.15A 6drzA-2cygA:
undetectable		 6drzA-2cygA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eh0 KINESIN-LIKE PROTEIN
KIF1B

(Homo sapiens) 		PF00498
(FHA)
PF16183
(Kinesin_assoc) 		5 THR A  82
VAL A  12
LEU A  11
PHE A  60
ASN A  99
 None
 1.15A 6drzA-2eh0A:
undetectable		 6drzA-2eh0A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A

(Homo sapiens) 		PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 VAL A 341
LEU A 327
PHE A 350
PHE A 316
VAL A 315
 None
 1.16A 6drzA-2id5A:
undetectable		 6drzA-2id5A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfn GLUTAMATE RACEMASE

(Escherichia
coli) 		PF01177
(Asp_Glu_race) 		5 VAL A 166
SER A 162
THR A 135
PHE A  58
GLY A  61
 None
None
GLU  A1287 ( 4.2A)
GLU  A1287 (-4.5A)
GLU  A1287 (-3.5A)
 1.02A 6drzA-2jfnA:
undetectable		 6drzA-2jfnA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kom PARTITIONING
DEFECTIVE 3 HOMOLOG

(Homo sapiens) 		PF00595
(PDZ) 		5 VAL A 540
VAL A 528
LEU A 531
PHE A 473
VAL A 517
 None
 1.16A 6drzA-2komA:
undetectable		 6drzA-2komA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsc FAB F425-B4E8, HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 219
THR H 217
VAL H 223
GLY H 118
VAL H 154
 None
 1.00A 6drzA-2qscH:
undetectable		 6drzA-2qscH:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xra HK20, HUMAN
MONOCLONAL ANTIBODY
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 207
THR H 205
VAL H 211
GLY H 118
VAL H 152
 None
 1.01A 6drzA-2xraH:
undetectable		 6drzA-2xraH:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrobaculum
aerophilum) 		PF07995
(GSDH) 		5 VAL A 229
THR A 231
PHE A 311
VAL A 265
TYR A 250
 None
None
None
TRE  A2002 (-3.8A)
None
 1.16A 6drzA-3a9gA:
undetectable		 6drzA-3a9gA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e60 3-OXOACYL-[ACYL-CARR
IER-PROTEIN ]
SYNTHASE II

(Bartonella
henselae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 VAL A  54
THR A  61
GLY A  57
VAL A  81
TYR A  82
 None
 1.13A 6drzA-3e60A:
undetectable		 6drzA-3e60A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8h PUTATIVE POLYKETIDE
CYCLASE

(Ruegeria sp.
TM1040) 		PF12680
(SnoaL_2) 		5 VAL A 116
THR A 118
LEU A  24
PHE A  44
PHE A   9
 None
MPD  A 133 ( 3.3A)
None
None
None
 1.08A 6drzA-3f8hA:
undetectable		 6drzA-3f8hA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go1 FAB 268-D, HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 207
THR H 205
VAL H 211
GLY H 118
VAL H 152
 None
 1.00A 6drzA-3go1H:
undetectable		 6drzA-3go1H:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hnr PROBABLE
METHYLTRANSFERASE
BT9727_4108

(Bacillus
thuringiensis) 		PF08241
(Methyltransf_11) 		5 VAL A  49
LEU A  50
PHE A 101
PHE A 143
PHE A 116
 None
 1.16A 6drzA-3hnrA:
undetectable		 6drzA-3hnrA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu4 CHP3 FAB HEAVY CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 207
THR H 205
VAL H 211
GLY H 118
VAL H 152
 None
 1.05A 6drzA-3iu4H:
undetectable		 6drzA-3iu4H:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE II

(Brucella
melitensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 VAL A  54
THR A  61
GLY A  57
VAL A  81
TYR A  82
 None
 1.12A 6drzA-3kzuA:
undetectable		 6drzA-3kzuA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqa HEAVY CHAIN OF ANTI
HIV FAB FROM HUMAN
21C ANTIBODY

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 219
THR H 217
VAL H 223
GLY H 130
VAL H 164
 None
 0.92A 6drzA-3lqaH:
undetectable		 6drzA-3lqaH:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mlw HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 1006-15D
FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 207
THR H 205
VAL H 211
GLY H 118
VAL H 152
 None
 1.07A 6drzA-3mlwH:
undetectable		 6drzA-3mlwH:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p30 1281 FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 207
THR H 205
VAL H 211
GLY H 118
VAL H 152
 None
 0.96A 6drzA-3p30H:
undetectable		 6drzA-3p30H:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 VAL A 111
THR A 115
PHE A 188
PHE A 346
TYR A 373
 ETQ  A1200 (-3.4A)
None
None
ETQ  A1200 ( 4.5A)
ETQ  A1200 (-4.4A)
 0.75A 6drzA-3pblA:
14.7		 6drzA-3pblA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 VAL A 111
THR A 115
PHE A 345
PHE A 346
TYR A 373
 ETQ  A1200 (-3.4A)
None
ETQ  A1200 (-4.4A)
ETQ  A1200 ( 4.5A)
ETQ  A1200 (-4.4A)
 0.70A 6drzA-3pblA:
14.7		 6drzA-3pblA:
29.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 VAL A 114
PHE A 289
PHE A 290
ASN A 293
TYR A 316
 ERC  A1201 (-3.8A)
ERC  A1201 (-4.5A)
ERC  A1201 (-4.8A)
ERC  A1201 (-3.5A)
None
 0.60A 6drzA-3pdsA:
28.4		 6drzA-3pdsA:
30.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 VAL A 114
THR A 118
PHE A 289
PHE A 290
ASN A 293
 ERC  A1201 (-3.8A)
None
ERC  A1201 (-4.5A)
ERC  A1201 (-4.8A)
ERC  A1201 (-3.5A)
 0.75A 6drzA-3pdsA:
28.4		 6drzA-3pdsA:
30.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3piq HUMAN MONOCLONAL
ANTIBODY 2909 FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 5 VAL H 207
THR H 205
VAL H 211
GLY H 118
VAL H 152
 None
 1.08A 6drzA-3piqH:
undetectable		 6drzA-3piqH:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qhf HUMAN MONOCLONAL
ANTIBODY DEL2D1,
FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 219
THR H 217
VAL H 223
GLY H 118
VAL H 154
 None
 1.07A 6drzA-3qhfH:
undetectable		 6drzA-3qhfH:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4y THIAMIN
PYROPHOSPHOKINASE 1

(Homo sapiens) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		5 VAL A  22
LEU A 105
GLY A  48
PHE A  67
ASN A  69
 None
 1.11A 6drzA-3s4yA:
undetectable		 6drzA-3s4yA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdy ANTIBODY CR8020,
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 207
THR H 205
VAL H 211
GLY H 118
VAL H 152
 None
 1.09A 6drzA-3sdyH:
undetectable		 6drzA-3sdyH:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulv FAB12 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL D 216
THR D 214
VAL D 220
GLY D 127
VAL D 161
 None
 0.99A 6drzA-3ulvD:
undetectable		 6drzA-3ulvD:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whe IMMUNOGLOBULIN HEAVY
CHAIN

(Homo sapiens) 		no annotation 5 VAL M 220
THR M 218
VAL M 224
GLY M 131
VAL M 165
 None
 1.08A 6drzA-3wheM:
undetectable		 6drzA-3wheM:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE

(Homo sapiens) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		5 LEU A 142
PHE A 143
GLY A 187
PHE A 238
PHE A 237
 None
SAM  A1349 (-3.8A)
SAM  A1349 (-3.6A)
SAM  A1349 (-4.7A)
SAM  A1349 (-3.5A)
 1.12A 6drzA-4a6eA:
undetectable		 6drzA-4a6eA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6z FAMILY M14
UNASSIGNED PEPTIDASE

(Burkholderia
cenocepacia) 		PF00246
(Peptidase_M14) 		5 THR A 153
VAL A 378
LEU A 377
PHE A 209
VAL A 164
 None
 0.89A 6drzA-4b6zA:
undetectable		 6drzA-4b6zA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 SER A 373
THR A 427
VAL A 505
GLY A 425
VAL A 337
 None
 1.15A 6drzA-4c7vA:
undetectable		 6drzA-4c7vA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1e ALPHA-ACTININ-2

(Homo sapiens) 		PF00307
(CH)
PF00435
(Spectrin)
PF08726
(EFhand_Ca_insen) 		5 VAL A 614
LEU A 565
PHE A 561
GLY A 534
PHE A 528
 None
MLZ  A 562 ( 4.2A)
MLZ  A 562 ( 4.5A)
None
None
 1.12A 6drzA-4d1eA:
3.2		 6drzA-4d1eA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4g APNAA1

(Planktothrix
agardhii) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 VAL A 231
SER A 234
VAL A 253
LEU A 256
VAL A 270
 None
 1.08A 6drzA-4d4gA:
undetectable		 6drzA-4d4gA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fj6 GLYCOSIDE HYDROLASE
FAMILY 33, CANDIDATE
SIALIDASE

(Parabacteroides
distasonis) 		PF13859
(BNR_3)
PF14873
(BNR_assoc_N) 		5 VAL A  93
SER A  91
LEU A 108
GLY A  79
VAL A  40
 None
PO4  A 606 (-4.0A)
None
None
None
 1.14A 6drzA-4fj6A:
undetectable		 6drzA-4fj6A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn5 ELONGATION FACTOR G
1

(Pseudomonas
aeruginosa) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		5 VAL A 418
SER A 417
GLY A 462
PHE A 445
VAL A 447
 None
 1.14A 6drzA-4fn5A:
undetectable		 6drzA-4fn5A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqk ANTIBODY CR8059
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL E 207
THR E 205
VAL E 211
GLY E 118
VAL E 152
 None
 1.01A 6drzA-4fqkE:
undetectable		 6drzA-4fqkE:
18.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		6 VAL A 114
THR A 118
PHE A 261
PHE A 262
ASN A 265
TYR A 288
 CAU  A 500 (-3.5A)
CAU  A 500 ( 4.7A)
CAU  A 500 (-4.2A)
CAU  A 500 (-4.6A)
CAU  A 500 (-3.4A)
CAU  A 500 (-4.6A)
 0.79A 6drzA-4gbrA:
28.8		 6drzA-4gbrA:
30.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		5 VAL A 136
SER A 139
LEU A 209
PHE A 217
PHE A 340
 ERM  A2001 (-3.8A)
ERM  A2001 (-3.6A)
ERM  A2001 (-3.7A)
ERM  A2001 (-4.6A)
ERM  A2001 (-4.3A)
 1.12A 6drzA-4ib4A:
43.7		 6drzA-4ib4A:
99.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		11 VAL A 136
SER A 139
THR A 140
VAL A 208
LEU A 209
PHE A 217
PHE A 340
PHE A 341
ASN A 344
VAL A 366
TYR A 370
 ERM  A2001 (-3.8A)
ERM  A2001 (-3.6A)
ERM  A2001 (-3.9A)
ERM  A2001 (-4.0A)
ERM  A2001 (-3.7A)
ERM  A2001 (-4.6A)
ERM  A2001 (-4.3A)
None
ERM  A2001 (-4.3A)
ERM  A2001 ( 4.2A)
ERM  A2001 ( 4.8A)
 0.55A 6drzA-4ib4A:
43.7		 6drzA-4ib4A:
99.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iml CROSSED LIGHT CHAIN
(VL-CH1)

(Homo sapiens) 		no annotation 5 VAL L 204
THR L 202
VAL L 208
GLY L 115
VAL L 149
 None
 1.10A 6drzA-4imlL:
undetectable		 6drzA-4imlL:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irz FAB NATALIZUMAB
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 217
THR H 215
VAL H 221
GLY H 128
VAL H 162
 None
 1.06A 6drzA-4irzH:
undetectable		 6drzA-4irzH:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb9 ANTIBODY VRC06 HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set) 		5 VAL H 207
THR H 205
VAL H 211
GLY H 118
VAL H 152
 None
 0.89A 6drzA-4jb9H:
undetectable		 6drzA-4jb9H:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jge RED FLUORESCENT
PROTEIN BLFP-R5

(Branchiostoma
lanceolatum) 		PF01353
(GFP) 		5 VAL A  54
LEU A  53
PHE A  20
GLY A  17
PHE A 123
 None
 1.04A 6drzA-4jgeA:
undetectable		 6drzA-4jgeA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpw HEAVY CHAIN OF
ANTIBODY 12A21

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 207
THR H 205
VAL H 211
GLY H 118
VAL H 152
 None
 1.03A 6drzA-4jpwH:
undetectable		 6drzA-4jpwH:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 VAL A1114
THR A1118
PHE A1289
PHE A1290
ASN A1293
TYR A1316
 P0G  A1401 (-3.7A)
None
P0G  A1401 ( 4.7A)
P0G  A1401 ( 4.9A)
P0G  A1401 (-3.0A)
None
 0.39A 6drzA-4ldeA:
29.2		 6drzA-4ldeA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Proteus
mirabilis) 		PF02028
(BCCT) 		5 PHE A 485
GLY A 480
PHE A  55
VAL A  50
TYR A  46
 None
 1.14A 6drzA-4m8jA:
2.1		 6drzA-4m8jA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwf FAB AR3C HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL A 207
THR A 205
VAL A 211
GLY A 118
VAL A 152
 None
 1.04A 6drzA-4mwfA:
undetectable		 6drzA-4mwfA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ngu TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Desulfovibrio
alaskensis) 		PF03480
(DctP) 		5 VAL A 241
GLY A 314
PHE A 174
PHE A 193
VAL A 168
 None
 1.04A 6drzA-4nguA:
undetectable		 6drzA-4nguA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		5 VAL A  -8
SER A  -9
LEU A  52
GLY A  60
VAL A  71
 None
None
None
GOL  A 306 (-3.0A)
GOL  A 304 (-4.5A)
 1.09A 6drzA-4nwkA:
undetectable		 6drzA-4nwkA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4od1 CAP256-VRC26.03
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 207
THR H 205
VAL H 211
GLY H 118
VAL H 152
 None
 1.04A 6drzA-4od1H:
undetectable		 6drzA-4od1H:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnr PGT130 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL A 207
THR A 205
VAL A 211
GLY A 118
VAL A 152
 None
 1.00A 6drzA-4rnrA:
undetectable		 6drzA-4rnrA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zf4 GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		5 VAL A  11
LEU A  10
PHE A 220
PHE A  50
PHE A  80
 4NT  A  15 ( 4.5A)
None
None
None
None
 1.16A 6drzA-4zf4A:
undetectable		 6drzA-4zf4A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5alc ANTI-TICAGRELOR FAB
72, HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 207
THR H 205
VAL H 211
GLY H 118
VAL H 152
 None
 1.05A 6drzA-5alcH:
undetectable		 6drzA-5alcH:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bzd 5G8 HIV ANTIBODY
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL B 207
THR B 205
VAL B 211
GLY B 118
VAL B 152
 None
 1.10A 6drzA-5bzdB:
undetectable		 6drzA-5bzdB:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE

(Thermoproteus
uzoniensis) 		PF01063
(Aminotran_4) 		6 VAL A 216
THR A 212
VAL A 197
LEU A 198
PHE A 244
GLY A 247
 None
PLP  A 301 (-3.6A)
None
None
None
PLP  A 301 ( 3.7A)
 1.28A 6drzA-5ce8A:
undetectable		 6drzA-5ce8A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1z D4-10 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL D 222
THR D 220
VAL D 226
GLY D 133
VAL D 167
 None
 0.97A 6drzA-5d1zD:
undetectable		 6drzA-5d1zD:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5diy HYALURONIDASE

(Thermobaculum
terrenum) 		PF07555
(NAGidase) 		5 VAL A 448
SER A 451
THR A 452
LEU A 347
PHE A 397
 None
 1.12A 6drzA-5diyA:
4.1		 6drzA-5diyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmg RB86 ANTIBODY FAB
FRAGMENT HEAVY CHAIN

(Oryctolagus
cuniculus) 		no annotation 5 VAL H1093
THR H1091
VAL H1097
GLY H1004
VAL H1038
 None
 1.04A 6drzA-5dmgH:
undetectable		 6drzA-5dmgH:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5drz HIV ANTIBODY F240
HEAVY CHAIN

(Homo sapiens) 		no annotation 5 VAL H 207
THR H 205
VAL H 211
GLY H 118
VAL H 152
 None
 1.07A 6drzA-5drzH:
undetectable		 6drzA-5drzH:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqq NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		5 VAL A 992
SER A 991
LEU A1052
GLY A1060
VAL A1071
 None
None
None
SO4  A1201 ( 4.0A)
None
 1.15A 6drzA-5eqqA:
undetectable		 6drzA-5eqqA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esv CH03 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL A 207
THR A 205
VAL A 211
GLY A 118
VAL A 152
 None
 1.08A 6drzA-5esvA:
undetectable		 6drzA-5esvA:
19.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 6 VAL B 122
THR B 126
PHE B 306
PHE B 307
ASN B 310
TYR B 333
 P32  B 400 (-3.5A)
None
P32  B 400 (-4.1A)
P32  B 400 (-4.9A)
P32  B 400 (-3.5A)
P32  B 400 (-4.6A)
 0.71A 6drzA-5f8uB:
29.4		 6drzA-5f8uB:
30.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 6 VAL B 122
THR B 126
VAL B 202
PHE B 306
PHE B 307
ASN B 310
 P32  B 400 (-3.5A)
None
None
P32  B 400 (-4.1A)
P32  B 400 (-4.9A)
P32  B 400 (-3.5A)
 1.03A 6drzA-5f8uB:
29.4		 6drzA-5f8uB:
30.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE

(Human
picobirnavirus) 		no annotation 5 VAL B 334
LEU B 280
GLY B 120
PHE B 225
VAL B 231
 None
 1.11A 6drzA-5i61B:
undetectable		 6drzA-5i61B:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12

(Homo sapiens) 		PF00443
(UCH) 		5 THR A 135
LEU A  54
PHE A 128
PHE A  63
VAL A  67
 None
 1.13A 6drzA-5k1cA:
undetectable		 6drzA-5k1cA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kan 16.G.07 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL G 222
THR G 220
VAL G 226
GLY G 133
VAL G 167
 None
 0.99A 6drzA-5kanG:
undetectable		 6drzA-5kanG:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kaq ANTIBODY 31.A.83 FAB
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL F 225
THR F 223
VAL F 229
GLY F 136
VAL F 170
 None
 0.94A 6drzA-5kaqF:
undetectable		 6drzA-5kaqF:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lug SPINDLIN-LIKE
PROTEIN 2, ISOFORM
CRA_A

(Homo sapiens) 		PF02513
(Spin-Ssty) 		5 VAL A 255
LEU A 254
PHE A 264
GLY A 211
VAL A 232
 None
 1.10A 6drzA-5lugA:
undetectable		 6drzA-5lugA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC

(synthetic
construct) 		no annotation 6 VAL D 127
VAL D  64
LEU D  63
PHE D  30
GLY D  27
PHE D 132
 None
 1.31A 6drzA-5mwcD:
undetectable		 6drzA-5mwcD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyx HEAVY CHAIN

(Homo sapiens) 		no annotation 5 VAL H 217
THR H 215
VAL H 221
GLY H 128
VAL H 162
 None
 1.07A 6drzA-5nyxH:
undetectable		 6drzA-5nyxH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3x IOMA HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL D 207
THR D 205
VAL D 211
GLY D 118
VAL D 152
 None
 1.01A 6drzA-5t3xD:
undetectable		 6drzA-5t3xD:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5q SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE

(Brucella
abortus) 		PF13561
(adh_short_C2) 		5 VAL A  11
THR A   9
VAL A 118
LEU A 121
GLY A  83
 None
 1.11A 6drzA-5t5qA:
undetectable		 6drzA-5t5qA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqa DH270.6 FAB HEAVY
CHAIN

(Homo sapiens) 		no annotation 5 VAL H 221
THR H 219
VAL H 225
GLY H 132
VAL H 166
 None
 1.10A 6drzA-5tqaH:
undetectable		 6drzA-5tqaH:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tud ANTI-5-HT2B FAB
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL C 221
THR C 219
VAL C 225
GLY C 132
VAL C 166
 None
 1.12A 6drzA-5tudC:
undetectable		 6drzA-5tudC:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vic FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 207
THR H 205
VAL H 211
GLY H 118
VAL H 152
 None
 1.09A 6drzA-5vicH:
undetectable		 6drzA-5vicH:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1k CR1-10 FAB HEAVY
CHAIN

(Homo sapiens) 		no annotation 5 VAL D 220
THR D 218
VAL D 224
GLY D 131
VAL D 165
 None
 1.02A 6drzA-5w1kD:
undetectable		 6drzA-5w1kD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w42 -

(-) 		no annotation 5 VAL H 207
THR H 205
VAL H 211
GLY H 118
VAL H 152
 None
 1.13A 6drzA-5w42H:
undetectable		 6drzA-5w42H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgx FLAVIN-DEPENDENT
HALOGENASE

(Malbranchea
aurantiaca) 		PF04820
(Trp_halogenase) 		5 VAL A 266
SER A 319
THR A 318
PHE A 359
PHE A 346
 None
 1.07A 6drzA-5wgxA:
undetectable		 6drzA-5wgxA:
19.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 6 VAL A 116
THR A 120
LEU A 187
PHE A 410
PHE A 411
TYR A 438
 AQD  A1201 ( 3.9A)
AQD  A1201 (-4.4A)
AQD  A1201 (-4.5A)
AQD  A1201 (-4.7A)
AQD  A1201 (-4.6A)
None
 0.76A 6drzA-5wivA:
30.8		 6drzA-5wivA:
50.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2o TASTE RECEPTOR, TYPE
1, MEMBER 3

(Oryzias latipes) 		PF01094
(ANF_receptor) 		5 THR B 319
GLY B 294
PHE B 284
VAL B 308
TYR B 309
 None
 1.05A 6drzA-5x2oB:
undetectable		 6drzA-5x2oB:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xao UNCHARACTERIZED
PROTEIN

(Parastagonospora
nodorum) 		PF01266
(DAO) 		5 VAL A 199
THR A 201
VAL A 365
GLY A 184
VAL A 224
 None
 0.93A 6drzA-5xaoA:
undetectable		 6drzA-5xaoA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apd AM22 FAB HEAVY
CHAIN,IGH@ PROTEIN

(Homo sapiens) 		no annotation 5 VAL D 207
THR D 205
VAL D 211
GLY D 118
VAL D 152
 None
 1.02A 6drzA-6apdD:
undetectable		 6drzA-6apdD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 6 SER A 138
PHE A 327
PHE A 328
ASN A 331
VAL A 354
TYR A 358
 E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
E2J  A1201 (-4.6A)
None
 0.62A 6drzA-6bqhA:
30.4		 6drzA-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 8 VAL A 135
SER A 138
THR A 139
LEU A 209
PHE A 327
PHE A 328
VAL A 354
TYR A 358
 E2J  A1201 (-3.8A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.3A)
None
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
E2J  A1201 (-4.6A)
None
 0.84A 6drzA-6bqhA:
30.4		 6drzA-6bqhA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		no annotation 5 VAL A 115
THR A 119
PHE A 389
PHE A 390
TYR A 416
 8NU  A2001 ( 3.5A)
8NU  A2001 ( 4.4A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
 0.79A 6drzA-6cm4A:
26.8		 6drzA-6cm4A:
33.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6db6 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 311-11D FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 5 VAL H 207
THR H 205
VAL H 211
GLY H 118
VAL H 152
 None
 1.06A 6drzA-6db6H:
undetectable		 6drzA-6db6H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6db7 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 1334 FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 5 VAL H 207
THR H 205
VAL H 211
GLY H 118
VAL H 152
 None
 1.07A 6drzA-6db7H:
undetectable		 6drzA-6db7H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eom MUTT/NUDIX FAMILY
PROTEIN

(Caldithrix
abyssi) 		no annotation 5 LEU A 377
PHE A 271
GLY A 430
PHE A 436
ASN A 423
 None
 1.07A 6drzA-6eomA:
2.5		 6drzA-6eomA:
undetectable