SIMILAR PATTERNS OF AMINO ACIDS FOR 6DRY_A_H8DA2001_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bfo | CAMPATH-1G ANTIBODY (Rattus rattus) |
PF07654(C1-set)PF07686(V-set) | 5 | VAL B 212THR B 210VAL B 216ALA B 126VAL B 160 | None | 1.15A | 6dryA-1bfoB:undetectable | 6dryA-1bfoB:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c0n | PROTEIN (CSDBPROTEIN) (Escherichiacoli) |
PF00266(Aminotran_5) | 6 | VAL A 358THR A 360VAL A 391LEU A 394ALA A 344VAL A 334 | None | 1.41A | 6dryA-1c0nA:undetectable | 6dryA-1c0nA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ehk | BA3-TYPECYTOCHROME-C OXIDASE (Thermusthermophilus) |
PF00115(COX1) | 5 | VAL A 79VAL A 26LEU A 27ALA A 120VAL A 34 | None | 1.32A | 6dryA-1ehkA:5.4 | 6dryA-1ehkA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fdr | FLAVODOXIN REDUCTASE (Escherichiacoli) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 5 | SER A 53VAL A 140LEU A 139ALA A 33TYR A 247 | FAD A 249 (-3.7A)NoneNoneNoneFAD A 249 (-3.4A) | 1.28A | 6dryA-1fdrA:undetectable | 6dryA-1fdrA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fnz | BARK AGGLUTININ I,POLYPEPTIDE A (Robiniapseudoacacia) |
PF00139(Lectin_legB) | 5 | VAL A 166LEU A 89ALA A 179GLN A 222TYR A 183 | None | 1.22A | 6dryA-1fnzA:undetectable | 6dryA-1fnzA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gwi | CYTOCHROME P450154C1 (Streptomycescoelicolor) |
PF00067(p450) | 5 | VAL A 256SER A 259THR A 260LEU A 399VAL A 404 | None | 1.02A | 6dryA-1gwiA:0.8 | 6dryA-1gwiA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iyx | ENOLASE (Enterococcushirae) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | ASP A 82VAL A 83SER A 1THR A 26ALA A 30 | None | 1.21A | 6dryA-1iyxA:undetectable | 6dryA-1iyxA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pvg | DNA TOPOISOMERASE II (Saccharomycescerevisiae) |
PF00204(DNA_gyraseB)PF02518(HATPase_c) | 5 | VAL A 86VAL A 69LEU A 68PHE A 199VAL A 197 | None | 1.33A | 6dryA-1pvgA:undetectable | 6dryA-1pvgA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qh1 | PROTEIN (NITROGENASEMOLYBDENUM IRONPROTEIN) (Klebsiellapneumoniae) |
PF00148(Oxidored_nitro)PF11844(DUF3364) | 5 | SER B 148THR B 149LEU B 133ALA B 153VAL B 112 | None | 1.29A | 6dryA-1qh1B:undetectable | 6dryA-1qh1B:23.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qh1 | PROTEIN (NITROGENASEMOLYBDENUM IRONPROTEIN) (Klebsiellapneumoniae) |
PF00148(Oxidored_nitro)PF11844(DUF3364) | 5 | VAL B 147SER B 148THR B 149LEU B 133VAL B 112 | None | 1.36A | 6dryA-1qh1B:undetectable | 6dryA-1qh1B:23.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tc5 | PROBABLE EUKARYOTICD-AMINO ACID TRNADEACYLASE,LMAJ005534AAA (Leishmaniamajor) |
PF02580(Tyr_Deacylase) | 5 | VAL A 64VAL A 38LEU A 15PHE A 129VAL A 133 | None | 1.35A | 6dryA-1tc5A:undetectable | 6dryA-1tc5A:16.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1twy | ABC TRANSPORTER,PERIPLASMICSUBSTRATE-BINDINGPROTEIN (Vibrio cholerae) |
PF12727(PBP_like) | 5 | VAL A 146THR A 180VAL A 108ALA A 178VAL A 184 | None | 1.35A | 6dryA-1twyA:undetectable | 6dryA-1twyA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u2e | 2-HYDROXY-6-KETONONA-2,4-DIENEDIOIC ACIDHYDROLASE (Escherichiacoli) |
PF12697(Abhydrolase_6) | 5 | ASP A 235VAL A 238THR A 148PHE A 173GLN A 266 | None | 1.29A | 6dryA-1u2eA:undetectable | 6dryA-1u2eA:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uzr | RIBONUCLEOTIDEREDUCTASE R2-2 SMALLSUBUNIT (Mycobacteriumtuberculosis) |
PF00268(Ribonuc_red_sm) | 5 | VAL A 143SER A 146LEU A 166VAL A 157TYR A 226 | None | 1.35A | 6dryA-1uzrA:undetectable | 6dryA-1uzrA:23.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2afh | NITROGENASEMOLYBDENUM-IRONPROTEIN (Azotobactervinelandii) |
PF00148(Oxidored_nitro)PF11844(DUF3364) | 5 | SER B 150THR B 151LEU B 135ALA B 155VAL B 114 | None | 1.31A | 6dryA-2afhB:undetectable | 6dryA-2afhB:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2afh | NITROGENASEMOLYBDENUM-IRONPROTEIN (Azotobactervinelandii) |
PF00148(Oxidored_nitro)PF11844(DUF3364) | 5 | VAL B 149SER B 150THR B 151LEU B 135VAL B 114 | None | 1.35A | 6dryA-2afhB:undetectable | 6dryA-2afhB:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b34 | MAR1 RIBONUCLEASE (Caenorhabditiselegans) |
PF00857(Isochorismatase) | 5 | VAL A 132THR A 160LEU A 17ALA A 163VAL A 129 | None | 1.29A | 6dryA-2b34A:undetectable | 6dryA-2b34A:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c5u | RNA LIGASE (Escherichiavirus T4) |
PF09511(RNA_lig_T4_1) | 5 | SER A 70LEU A 178ALA A 150PHE A 116VAL A 105 | None | 1.31A | 6dryA-2c5uA:1.5 | 6dryA-2c5uA:24.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gb3 | ASPARTATEAMINOTRANSFERASE (Thermotogamaritima) |
PF00155(Aminotran_1_2) | 5 | ASP A 228VAL A 203SER A 205VAL A 241TYR A 79 | None | 1.21A | 6dryA-2gb3A:undetectable | 6dryA-2gb3A:24.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gb3 | ASPARTATEAMINOTRANSFERASE (Thermotogamaritima) |
PF00155(Aminotran_1_2) | 5 | ASP A 228VAL A 203SER A 205VAL A 241TYR A 80 | None | 1.31A | 6dryA-2gb3A:undetectable | 6dryA-2gb3A:24.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ijd | PICORNAIN 3C,RNA-DIRECTED RNAPOLYMERASE (Enterovirus C) |
PF00548(Peptidase_C3)PF00680(RdRP_1) | 5 | VAL 1 150LEU 1 174ALA 1 7VAL 1 119TYR 1 138 | None | 1.21A | 6dryA-2ijd1:undetectable | 6dryA-2ijd1:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2im5 | NICOTINATEPHOSPHORIBOSYLTRANSFERASE (Porphyromonasgingivalis) |
PF04095(NAPRTase) | 5 | SER A 195THR A 194VAL A 126ALA A 200TYR A 13 | None | 1.13A | 6dryA-2im5A:undetectable | 6dryA-2im5A:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2irp | PUTATIVE ALDOLASECLASS 2 PROTEINAQ_1979 (Aquifexaeolicus) |
PF00596(Aldolase_II) | 5 | VAL A 98SER A 37ALA A 19VAL A 94TYR A 88 | None | 1.36A | 6dryA-2irpA:undetectable | 6dryA-2irpA:18.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2okx | RHAMNOSIDASE B (Bacillus sp.GL1) |
PF05592(Bac_rhamnosid)PF08531(Bac_rhamnosid_N)PF17389(Bac_rhamnosid6H)PF17390(Bac_rhamnosid_C) | 5 | VAL A 512THR A 461VAL A 440LEU A 439ALA A 457 | None | 1.20A | 6dryA-2okxA:1.2 | 6dryA-2okxA:17.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pfe | ALKALINE SERINEPROTEASE (Thermobifidafusca) |
PF00089(Trypsin) | 5 | THR A 201VAL A 47LEU A 242ALA A 130VAL A 212 | None | 1.32A | 6dryA-2pfeA:undetectable | 6dryA-2pfeA:16.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q3h | RAS HOMOLOG GENEFAMILY, MEMBER U (Homo sapiens) |
PF00071(Ras) | 5 | VAL A 66THR A 70VAL A 55ALA A 88VAL A 214 | None | 1.13A | 6dryA-2q3hA:undetectable | 6dryA-2q3hA:18.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qu7 | PUTATIVETRANSCRIPTIONALREGULATOR (Staphylococcussaprophyticus) |
PF13407(Peripla_BP_4) | 5 | VAL A 304VAL A 160LEU A 323GLN A 296VAL A 81 | None | 1.10A | 6dryA-2qu7A:undetectable | 6dryA-2qu7A:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x7j | 2-SUCCINYL-5-ENOLPYRUVYL-6-HYDROXY-3-CYCLOHEXENE-1-CARBOXYLATESYNTHASE (Bacillussubtilis) |
PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N)PF16582(TPP_enzyme_M_2) | 5 | VAL A 101THR A 103VAL A 97ALA A 82VAL A 26 | None | 1.24A | 6dryA-2x7jA:undetectable | 6dryA-2x7jA:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yev | CYTOCHROME C OXIDASEPOLYPEPTIDE I+IIICAA3-TYPE CYTOCHROMEOXIDASE SUBUNIT IV (Thermusthermophilus;Thermusthermophilus) |
PF00115(COX1)PF00510(COX3)no annotation | 5 | ASP A 778VAL A 668SER A 671VAL A 783VAL C 39 | None | 1.34A | 6dryA-2yevA:2.0 | 6dryA-2yevA:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b9k | FAB HEAVY CHAIN (Rattus rattus) |
no annotation | 5 | VAL H 219THR H 217VAL H 223ALA H 118VAL H 154 | None | 1.13A | 6dryA-3b9kH:undetectable | 6dryA-3b9kH:17.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eqn | GLUCAN1,3-BETA-GLUCOSIDASE (Phanerochaetechrysosporium) |
PF12708(Pectate_lyase_3) | 5 | VAL A 153VAL A 101PHE A 89GLN A 64VAL A 87 | None | 1.14A | 6dryA-3eqnA:undetectable | 6dryA-3eqnA:17.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fpk | FERREDOXIN-NADPREDUCTASE (Salmonellaenterica) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 5 | SER A 53VAL A 140LEU A 139ALA A 33TYR A 247 | FAD A 301 (-3.6A)NoneNoneNoneFAD A 301 (-3.3A) | 1.28A | 6dryA-3fpkA:undetectable | 6dryA-3fpkA:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gbp | GALACTOSE-BINDINGPROTEIN (Salmonellaenterica) |
PF13407(Peripla_BP_4) | 5 | VAL A 68ALA A 258PHE A 90GLN A 48TYR A 107 | None | 1.16A | 6dryA-3gbpA:undetectable | 6dryA-3gbpA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ke6 | PROTEINRV1364C/MT1410 (Mycobacteriumtuberculosis) |
PF07228(SpoIIE)PF13581(HATPase_c_2) | 5 | VAL A 170SER A 169VAL A 206LEU A 205TYR A -6 | None | 1.27A | 6dryA-3ke6A:undetectable | 6dryA-3ke6A:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lad | DIHYDROLIPOAMIDEDEHYDROGENASE (Azotobactervinelandii) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | VAL A 6THR A 29VAL A 310ALA A 19VAL A 129 | None | 1.35A | 6dryA-3ladA:2.3 | 6dryA-3ladA:23.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mh9 | LIPOPROTEIN LPRG (Mycobacteriumtuberculosis) |
no annotation | 5 | THR C 49VAL C 217LEU C 209ALA C 147VAL C 135 | None | 1.28A | 6dryA-3mh9C:undetectable | 6dryA-3mh9C:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mha | LIPOPROTEIN LPRG (Mycobacteriumtuberculosis) |
PF07161(LppX_LprAFG) | 5 | THR A 49VAL A 217LEU A 209ALA A 147VAL A 135 | None | 1.28A | 6dryA-3mhaA:undetectable | 6dryA-3mhaA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o0d | TRIACYLGLYCEROLLIPASE (Yarrowialipolytica) |
PF01764(Lipase_3)PF03893(Lipase3_N) | 5 | VAL A 158VAL A 147LEU A 144ALA A 167PHE A 59 | NoneNoneNAG A 302 ( 4.9A)NoneNone | 1.32A | 6dryA-3o0dA:undetectable | 6dryA-3o0dA:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qk8 | ENOYL-COA HYDRATASEECHA15 (Mycobacteriummarinum) |
PF00378(ECH_1) | 5 | VAL A 129SER A 186THR A 187VAL A 57LEU A 58 | NoneNoneEDO A 297 (-4.0A)NoneNone | 1.34A | 6dryA-3qk8A:1.6 | 6dryA-3qk8A:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rkd | CAPSID PROTEIN (OrthohepevirusA) |
PF03014(SP2) | 5 | VAL A 579SER A 495VAL A 501LEU A 500GLN A 508 | None | 1.26A | 6dryA-3rkdA:undetectable | 6dryA-3rkdA:14.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s51 | FANCONI ANEMIA GROUPI PROTEIN HOMOLOG (Mus musculus) |
PF14674(FANCI_S1-cap)PF14675(FANCI_S1)PF14676(FANCI_S2)PF14677(FANCI_S3)PF14678(FANCI_S4)PF14679(FANCI_HD1)PF14680(FANCI_HD2) | 5 | VAL A 219LEU A 218ALA A 235PHE A 202VAL A 198 | None | 1.20A | 6dryA-3s51A:undetectable | 6dryA-3s51A:15.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t38 | ARSENATE REDUCTASE (Corynebacteriumglutamicum) |
PF01451(LMWPc) | 5 | ASP A 149VAL A 150LEU A 146PHE A 62TYR A 37 | NoneNoneNoneNoneD1D A3236 (-3.6A) | 1.08A | 6dryA-3t38A:undetectable | 6dryA-3t38A:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tmq | 2-DEHYDRO-3-DEOXYPHOSPHOOCTONATEALDOLASE 2 (Burkholderiapseudomallei) |
PF00793(DAHP_synth_1) | 5 | VAL A 94THR A 92VAL A 124ALA A 107VAL A 135 | None | 1.22A | 6dryA-3tmqA:undetectable | 6dryA-3tmqA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u7v | BETA-GALACTOSIDASE (Caulobactervibrioides) |
PF02449(Glyco_hydro_42) | 5 | VAL A 474LEU A 473ALA A 355VAL A 489TYR A 445 | None | 1.30A | 6dryA-3u7vA:undetectable | 6dryA-3u7vA:22.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w9i | MULTIDRUG RESISTANCEPROTEIN MEXB (Pseudomonasaeruginosa) |
PF00873(ACR_tran) | 5 | VAL A1027SER A1028THR A1029LEU A 902VAL A 945 | None | 1.22A | 6dryA-3w9iA:undetectable | 6dryA-3w9iA:18.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zv8 | 3C PROTEASE (Enterovirus D) |
PF00548(Peptidase_C3) | 5 | VAL A 150LEU A 174ALA A 7VAL A 119TYR A 138 | None | 1.15A | 6dryA-3zv8A:undetectable | 6dryA-3zv8A:18.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4abn | TETRATRICOPEPTIDEREPEAT PROTEIN 5 (Mus musculus) |
PF16669(TTC5_OB) | 5 | VAL A 337THR A 335VAL A 341LEU A 357VAL A 417 | None | 1.34A | 6dryA-4abnA:2.8 | 6dryA-4abnA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ex9 | ALNA (Streptomycessp. CM020) |
PF04227(Indigoidine_A) | 5 | SER A 155LEU A 32ALA A 292PHE A 121VAL A 106 | NoneNoneNoneNone5RP A 402 (-4.0A) | 1.36A | 6dryA-4ex9A:undetectable | 6dryA-4ex9A:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g68 | ABC TRANSPORTER (Caldanaerobius) |
PF01547(SBP_bac_1) | 5 | THR B 177LEU B 164ALA B 258PHE B 150VAL B 155 | None | 1.24A | 6dryA-4g68B:undetectable | 6dryA-4g68B:21.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4gbr | BETA-2 ADRENERGICRECEPTOR (Homo sapiens) |
PF00001(7tm_1) | 5 | ASP A 113VAL A 114THR A 118PHE A 261TYR A 288 | CAU A 500 (-3.0A)CAU A 500 (-3.5A)CAU A 500 ( 4.7A)CAU A 500 (-4.2A)CAU A 500 (-4.6A) | 0.84A | 6dryA-4gbrA:26.6 | 6dryA-4gbrA:30.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gfh | DNA TOPOISOMERASE 2 (Saccharomycescerevisiae) |
PF00204(DNA_gyraseB)PF00521(DNA_topoisoIV)PF01751(Toprim)PF02518(HATPase_c)PF16898(TOPRIM_C) | 5 | VAL A 86VAL A 69LEU A 68PHE A 199VAL A 197 | None | 1.30A | 6dryA-4gfhA:2.7 | 6dryA-4gfhA:16.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ggv | CYTOCHROME P450SUPERFAMILY PROTEIN (Streptomyceshimastatinicus) |
PF00067(p450) | 5 | VAL A 105THR A 109LEU A 351ALA A 359VAL A 134 | None | 1.32A | 6dryA-4ggvA:undetectable | 6dryA-4ggvA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hbc | ANTIGEN BINDINGFRAGMENT,IMMUNOGLOBULIN IGG -HEAVY CHAIN (Oryctolaguscuniculus) |
PF07654(C1-set)PF07686(V-set) | 5 | VAL H 206THR H 204VAL H 210ALA H 120VAL H 154 | None | 1.14A | 6dryA-4hbcH:undetectable | 6dryA-4hbcH:15.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ib4 | CHIMERA PROTEIN OFHUMAN5-HYDROXYTRYPTAMINERECEPTOR 2B AND E.COLI SOLUBLECYTOCHROME B562 (Escherichiacoli;Homo sapiens) |
PF00001(7tm_1)PF07361(Cytochrom_B562) | 10 | ASP A 135VAL A 136SER A 139THR A 140VAL A 208LEU A 209ALA A 225PHE A 340VAL A 366TYR A 370 | ERM A2001 (-3.2A)ERM A2001 (-3.8A)ERM A2001 (-3.6A)ERM A2001 (-3.9A)ERM A2001 (-4.0A)ERM A2001 (-3.7A)ERM A2001 (-3.4A)ERM A2001 (-4.3A)ERM A2001 ( 4.2A)ERM A2001 ( 4.8A) | 0.41A | 6dryA-4ib4A:44.5 | 6dryA-4ib4A:99.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jo2 | MONOCLONALANTI-HIV-1 GP120 V3ANTIBODY R56 HEAVYCHAIN (Oryctolaguscuniculus) |
PF07654(C1-set)PF07686(V-set) | 5 | VAL H 200THR H 198VAL H 204ALA H 114VAL H 148 | None | 1.15A | 6dryA-4jo2H:undetectable | 6dryA-4jo2H:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jo3 | MONOCLONALANTI-HIV-1 GP120 V3ANTIBODY R20 HEAVYCHAIN (Oryctolaguscuniculus) |
PF07654(C1-set)PF07686(V-set) | 5 | VAL H 204THR H 202VAL H 208ALA H 118VAL H 152 | None | 1.11A | 6dryA-4jo3H:undetectable | 6dryA-4jo3H:17.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k3d | BOVINE ANTIBODY WITHULTRALONG CDR H3,HEAVY CHAIN (Bos taurus) |
PF07654(C1-set)PF07686(V-set) | 5 | VAL H 206THR H 204VAL H 210ALA H 118VAL H 152 | None | 1.21A | 6dryA-4k3dH:undetectable | 6dryA-4k3dH:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k3e | BOVINE ANTIBODY WITHULTRALONG CDR H3,HEAVY CHAIN (Bos taurus) |
PF07654(C1-set)PF07686(V-set) | 5 | VAL H 206THR H 204VAL H 210ALA H 118VAL H 152 | None | 1.07A | 6dryA-4k3eH:undetectable | 6dryA-4k3eH:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kvl | FATTY ACIDALPHA-OXIDASE (Oryza sativa) |
PF03098(An_peroxidase) | 5 | ASP A 36THR A 547VAL A 10LEU A 14TYR A 52 | None | 1.28A | 6dryA-4kvlA:0.7 | 6dryA-4kvlA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lde | LYSOZYME, BETA-2ADRENERGIC RECEPTOR (Homo sapiens;Escherichiavirus T4) |
PF00001(7tm_1)PF00959(Phage_lysozyme) | 5 | ASP A1113VAL A1114THR A1118PHE A1289TYR A1316 | P0G A1401 (-2.9A)P0G A1401 (-3.7A)NoneP0G A1401 ( 4.7A)None | 0.47A | 6dryA-4ldeA:27.0 | 6dryA-4ldeA:25.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o94 | TRAP DICARBOXYLATETRANSPORTER DCTPSUBUNIT (Rhodopseudomonaspalustris) |
PF03480(DctP) | 5 | VAL A 60THR A 56VAL A 85ALA A 255PHE A 48 | None | 1.15A | 6dryA-4o94A:undetectable | 6dryA-4o94A:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4piv | FATTY ACID SYNTHASE (Homo sapiens) |
PF08242(Methyltransf_12)PF08659(KR) | 5 | VAL A1245LEU A1342ALA A1303VAL A1242TYR A1270 | None | 1.08A | 6dryA-4pivA:undetectable | 6dryA-4pivA:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qjl | PHOSPHOPANTETHEINYLTRANSFERASE, PPTII (Mycobacteriumulcerans) |
PF01648(ACPS) | 5 | THR A 92VAL A 15LEU A 11ALA A 115VAL A 162 | COA A 301 (-3.6A)NoneNoneNoneNone | 1.23A | 6dryA-4qjlA:undetectable | 6dryA-4qjlA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qme | AMINOPEPTIDASE N (Neisseriameningitidis) |
PF01433(Peptidase_M1)PF11940(DUF3458)PF17432(DUF3458_C) | 5 | VAL A 34THR A 92LEU A 185ALA A 55PHE A 121 | None | 1.25A | 6dryA-4qmeA:undetectable | 6dryA-4qmeA:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r9g | MBP1 (Caldanaerobiuspolysaccharolyticus) |
PF13416(SBP_bac_8) | 5 | ASP A 89VAL A 196LEU A 303GLN A 191TYR A 85 | ZN A 505 (-3.0A)NoneNoneBMA A 502 (-3.7A)None | 1.35A | 6dryA-4r9gA:undetectable | 6dryA-4r9gA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rot | ESTERASE A (Streptococcuspyogenes) |
PF00756(Esterase) | 5 | THR A 195VAL A 245LEU A 246ALA A 133GLN A 242 | None | 1.35A | 6dryA-4rotA:undetectable | 6dryA-4rotA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x9s | PHOSPHORIBOSYLISOMERASE A (Streptomycessp. Mg1) |
PF00977(His_biosynth) | 5 | VAL A 54SER A 83VAL A 223ALA A 59VAL A 166 | SO4 A 305 (-4.8A)SO4 A 301 ( 4.4A)SO4 A 303 ( 4.7A)SO4 A 301 (-3.4A)None | 1.34A | 6dryA-4x9sA:undetectable | 6dryA-4x9sA:22.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xbi | CLPB PROTEIN,PUTATIVE,GREENFLUORESCENT PROTEIN (Plasmodiumfalciparum;Aequoreavictoria) |
PF01353(GFP)PF02861(Clp_N) | 5 | VAL A 93SER A 97THR A 96VAL A 30TYR A 7 | None | 1.31A | 6dryA-4xbiA:undetectable | 6dryA-4xbiA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xcg | THERMOSOME SUBUNITBETA (Sulfolobussolfataricus) |
PF00118(Cpn60_TCP1) | 5 | VAL B 372LEU B 333ALA B 246GLN B 303VAL B 322 | None | 1.27A | 6dryA-4xcgB:undetectable | 6dryA-4xcgB:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yio | SUPEROXIDE DISMUTASE (Streptococcusthermophilus) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 5 | VAL A 98THR A 95VAL A 141LEU A 131PHE A 109 | None | 1.25A | 6dryA-4yioA:undetectable | 6dryA-4yioA:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yip | SUPEROXIDE DISMUTASE[MN/FE] (Streptococcusmutans) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 5 | VAL A 98THR A 95VAL A 141LEU A 131PHE A 109 | None | 1.24A | 6dryA-4yipA:undetectable | 6dryA-4yipA:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ztp | HEAVY CHAIN OF FABFRAGMENT OF RABBITMONOCLONAL ANTIBODYR53 (Oryctolaguscuniculus) |
PF07654(C1-set)PF07686(V-set) | 5 | VAL H 203THR H 201VAL H 207ALA H 117VAL H 151 | None | 1.08A | 6dryA-4ztpH:undetectable | 6dryA-4ztpH:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bpe | EV71 3CPRO (Enterovirus A) |
PF00548(Peptidase_C3) | 5 | VAL A 150LEU A 174ALA A 7VAL A 119TYR A 138 | None | 1.14A | 6dryA-5bpeA:undetectable | 6dryA-5bpeA:17.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5diy | HYALURONIDASE (Thermobaculumterrenum) |
PF07555(NAGidase) | 5 | VAL A 448SER A 451THR A 452LEU A 347PHE A 397 | None | 1.09A | 6dryA-5diyA:undetectable | 6dryA-5diyA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eue | PUTATIVESPHINGOSINE-1-PHOSPHATE LYASE (Symbiobacteriumthermophilum) |
PF00282(Pyridoxal_deC) | 5 | VAL A 164SER A 320THR A 319VAL A 160ALA A 362 | None | 1.28A | 6dryA-5eueA:undetectable | 6dryA-5eueA:21.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5f8u | BETA-1 ADRENERGICRECEPTOR (Meleagrisgallopavo) |
no annotation | 5 | ASP B 121VAL B 122THR B 126PHE B 306TYR B 333 | P32 B 400 (-2.2A)P32 B 400 (-3.5A)NoneP32 B 400 (-4.1A)P32 B 400 (-4.6A) | 0.81A | 6dryA-5f8uB:26.9 | 6dryA-5f8uB:30.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g4q | DNA POLYMERASE IIISUBUNIT BETA (Helicobacterpylori) |
PF00712(DNA_pol3_beta)PF02767(DNA_pol3_beta_2)PF02768(DNA_pol3_beta_3) | 5 | VAL A 170THR A 181LEU A 204ALA A 363VAL A 144 | None | 1.35A | 6dryA-5g4qA:undetectable | 6dryA-5g4qA:23.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i8k | HHH1 FAB LIGHT CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 5 | VAL L 11SER L 10THR L 105VAL L 15LEU L 80 | None | 1.21A | 6dryA-5i8kL:undetectable | 6dryA-5i8kL:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ihu | BOVINE FAB B11 HEAVYCHAIN (Bos taurus) |
PF07654(C1-set)PF07686(V-set) | 5 | VAL H 261THR H 259VAL H 265ALA H 173VAL H 207 | None | 1.06A | 6dryA-5ihuH:undetectable | 6dryA-5ihuH:19.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ijv | BOVINE FAB E03 HEAVYCHAIN (Bos taurus) |
no annotation | 5 | VAL H 242THR H 240VAL H 246ALA H 154VAL H 188 | None | 1.04A | 6dryA-5ijvH:undetectable | 6dryA-5ijvH:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ilt | BOVINE FAB A01 HEAVYCHAIN (Bos taurus) |
PF07654(C1-set)PF07686(V-set) | 5 | VAL H 259THR H 257VAL H 263ALA H 171VAL H 205 | None | 1.08A | 6dryA-5iltH:undetectable | 6dryA-5iltH:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j8q | CYSTEINE DESULFURASESUFS (Bacillussubtilis) |
PF00266(Aminotran_5) | 5 | VAL A 171SER A 169VAL A 332LEU A 331ALA A 200 | NoneNoneNoneNonePLP A 501 (-3.5A) | 1.30A | 6dryA-5j8qA:undetectable | 6dryA-5j8qA:22.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jxu | DYP-TYPE PEROXIDASEFAMILY (Thermomonosporacurvata) |
PF04261(Dyp_perox) | 5 | THR A 62VAL A 252LEU A 251ALA A 58VAL A 236 | None | 1.34A | 6dryA-5jxuA:undetectable | 6dryA-5jxuA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kte | DIVALENT METALCATION TRANSPORTERMNTH (Deinococcusradiodurans) |
PF01566(Nramp) | 5 | THR A 228VAL A 390LEU A 389ALA A 81VAL A 420 | None | 1.35A | 6dryA-5kteA:undetectable | 6dryA-5kteA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m23 | WD REPEAT-CONTAININGPROTEIN 5 (Homo sapiens) |
PF00400(WD40) | 5 | ASP A 92SER A 50VAL A 145ALA A 308PHE A 219 | 7DC A 401 ( 4.3A)NoneNoneNoneNone | 1.32A | 6dryA-5m23A:undetectable | 6dryA-5m23A:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m28 | MALE1 (Lactobacilluscasei) |
PF13416(SBP_bac_8) | 5 | ASP A 189VAL A 190SER A 192LEU A 177ALA A 198 | None | 1.27A | 6dryA-5m28A:undetectable | 6dryA-5m28A:24.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m63 | H CHAIN OF FABNVS-1-19-5 (Oryctolaguscuniculus) |
PF07654(C1-set)PF07686(V-set) | 5 | VAL H 235THR H 233VAL H 239ALA H 149VAL H 183 | None | 1.07A | 6dryA-5m63H:undetectable | 6dryA-5m63H:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ofk | GLYCOSIDE HYDROLASEFAMILY 48 (Caldicellulosiruptorbescii) |
PF00331(Glyco_hydro_10) | 5 | THR A 282LEU A 249ALA A 335PHE A 16VAL A 291 | None | 1.19A | 6dryA-5ofkA:undetectable | 6dryA-5ofkA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v54 | 5-HYDROXYTRYPTAMINERECEPTOR 1B,OB-1FUSED 5-HT1BRECEPTOR,5-HYDROXYTRYPTAMINE RECEPTOR 1B (Spodopterafrugiperda;Homo sapiens) |
no annotation | 5 | ASP A 129THR A 134ALA A 216PHE A 330TYR A 359 | 89F A1201 (-3.3A)89F A1201 (-4.2A)89F A1201 ( 3.9A)89F A1201 (-4.1A)None | 0.69A | 6dryA-5v54A:33.8 | 6dryA-5v54A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v6l | HEAVY CHAIN OF FABFRAGMENT OF RABBITANTI-HIV1 GP120 V3MAB 10A37 (Oryctolaguscuniculus) |
no annotation | 5 | VAL H 204THR H 202VAL H 208ALA H 118VAL H 152 | None | 1.16A | 6dryA-5v6lH:undetectable | 6dryA-5v6lH:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vgb | CRISPR-ASSOCIATEDENDONUCLEASE CAS9 (Neisseriameningitidis) |
PF13395(HNH_4) | 5 | SER A 37VAL A 93LEU A 92ALA A 20PHE A 87 | None | 1.17A | 6dryA-5vgbA:undetectable | 6dryA-5vgbA:15.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5voh | NADH OXIDASE (Lactobacillusbrevis) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | VAL A 108THR A 110VAL A 312LEU A 311ALA A 11 | NoneNoneNoneNoneFAD A 501 (-3.2A) | 1.10A | 6dryA-5vohA:undetectable | 6dryA-5vohA:23.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5wiv | D(4) DOPAMINERECEPTOR, SOLUBLECYTOCHROME B562CHIMERA (Escherichiacoli;Homo sapiens) |
no annotation | 6 | ASP A 115VAL A 116THR A 120LEU A 187PHE A 410TYR A 438 | AQD A1201 (-3.3A)AQD A1201 ( 3.9A)AQD A1201 (-4.4A)AQD A1201 (-4.5A)AQD A1201 (-4.7A)None | 0.84A | 6dryA-5wivA:30.8 | 6dryA-5wivA:50.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yb7 | L-AMINO ACIDOXIDASE/MONOOXYGENASE (Pseudomonas sp.AIU 813) |
no annotation | 5 | ASP A 21THR A 513LEU A 188VAL A 196TYR A 481 | None | 1.25A | 6dryA-5yb7A:undetectable | 6dryA-5yb7A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6arr | ACETYL-COAACETYLTRANSFERASE (Aspergillusfumigatus) |
no annotation | 5 | ASP A 222VAL A 17THR A 15VAL A 350ALA A 259 | NoneNoneNone CS A 402 (-4.6A)None | 1.13A | 6dryA-6arrA:undetectable | 6dryA-6arrA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bdz | DISINTEGRIN ANDMETALLOPROTEINASEDOMAIN-CONTAININGPROTEIN 10 (Homo sapiens) |
no annotation | 5 | VAL A 385VAL A 272LEU A 224ALA A 331PHE A 318 | None | 1.35A | 6dryA-6bdzA:undetectable | 6dryA-6bdzA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bqh | 5-HYDROXYTRYPTAMINERECEPTOR 2C,SOLUBLECYTOCHROME B562 (Escherichiacoli;Homo sapiens) |
no annotation | 9 | ASP A 134VAL A 135SER A 138THR A 139LEU A 209ALA A 222PHE A 327VAL A 354TYR A 358 | E2J A1201 (-3.0A)E2J A1201 (-3.8A)E2J A1201 (-3.2A)E2J A1201 (-4.3A)NoneE2J A1201 ( 3.8A)E2J A1201 (-4.6A)E2J A1201 (-4.6A)None | 0.88A | 6dryA-6bqhA:31.5 | 6dryA-6bqhA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bqh | 5-HYDROXYTRYPTAMINERECEPTOR 2C,SOLUBLECYTOCHROME B562 (Escherichiacoli;Homo sapiens) |
no annotation | 7 | ASP A 134VAL A 135SER A 138THR A 139VAL A 208LEU A 209ALA A 222 | E2J A1201 (-3.0A)E2J A1201 (-3.8A)E2J A1201 (-3.2A)E2J A1201 (-4.3A)NoneNoneE2J A1201 ( 3.8A) | 0.87A | 6dryA-6bqhA:31.5 | 6dryA-6bqhA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cfw | MONOVALENT CATION/H+ANTIPORTER SUBUNIT DMBH13 NADHDEHYDROGENASESUBUNIT (Pyrococcusfuriosus;Pyrococcusfuriosus) |
no annotationno annotation | 5 | VAL M 116SER M 120LEU H 391ALA M 71PHE M 66 | None | 1.36A | 6dryA-6cfwM:2.5 | 6dryA-6cfwM:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g79 | 5-HYDROXYTRYPTAMINERECEPTOR 1B (Homo sapiens) |
no annotation | 5 | ASP S 129THR S 134ALA S 216PHE S 330TYR S 359 | EP5 S 401 (-3.3A)EP5 S 401 (-3.8A)EP5 S 401 ( 4.0A)EP5 S 401 (-4.0A)EP5 S 401 ( 4.9A) | 0.45A | 6dryA-6g79S:26.5 | 6dryA-6g79S:undetectable |