SIMILAR PATTERNS OF AMINO ACIDS FOR 6DRY_A_H8DA2001_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bfo CAMPATH-1G ANTIBODY

(Rattus rattus)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL B 212
THR B 210
VAL B 216
ALA B 126
VAL B 160
None
1.15A 6dryA-1bfoB:
undetectable
6dryA-1bfoB:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0n PROTEIN (CSDB
PROTEIN)


(Escherichia
coli)
PF00266
(Aminotran_5)
6 VAL A 358
THR A 360
VAL A 391
LEU A 394
ALA A 344
VAL A 334
None
1.41A 6dryA-1c0nA:
undetectable
6dryA-1c0nA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehk BA3-TYPE
CYTOCHROME-C OXIDASE


(Thermus
thermophilus)
PF00115
(COX1)
5 VAL A  79
VAL A  26
LEU A  27
ALA A 120
VAL A  34
None
1.32A 6dryA-1ehkA:
5.4
6dryA-1ehkA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fdr FLAVODOXIN REDUCTASE

(Escherichia
coli)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
5 SER A  53
VAL A 140
LEU A 139
ALA A  33
TYR A 247
FAD  A 249 (-3.7A)
None
None
None
FAD  A 249 (-3.4A)
1.28A 6dryA-1fdrA:
undetectable
6dryA-1fdrA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fnz BARK AGGLUTININ I,
POLYPEPTIDE A


(Robinia
pseudoacacia)
PF00139
(Lectin_legB)
5 VAL A 166
LEU A  89
ALA A 179
GLN A 222
TYR A 183
None
1.22A 6dryA-1fnzA:
undetectable
6dryA-1fnzA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gwi CYTOCHROME P450
154C1


(Streptomyces
coelicolor)
PF00067
(p450)
5 VAL A 256
SER A 259
THR A 260
LEU A 399
VAL A 404
None
1.02A 6dryA-1gwiA:
0.8
6dryA-1gwiA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyx ENOLASE

(Enterococcus
hirae)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 ASP A  82
VAL A  83
SER A   1
THR A  26
ALA A  30
None
1.21A 6dryA-1iyxA:
undetectable
6dryA-1iyxA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvg DNA TOPOISOMERASE II

(Saccharomyces
cerevisiae)
PF00204
(DNA_gyraseB)
PF02518
(HATPase_c)
5 VAL A  86
VAL A  69
LEU A  68
PHE A 199
VAL A 197
None
1.33A 6dryA-1pvgA:
undetectable
6dryA-1pvgA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh1 PROTEIN (NITROGENASE
MOLYBDENUM IRON
PROTEIN)


(Klebsiella
pneumoniae)
PF00148
(Oxidored_nitro)
PF11844
(DUF3364)
5 SER B 148
THR B 149
LEU B 133
ALA B 153
VAL B 112
None
1.29A 6dryA-1qh1B:
undetectable
6dryA-1qh1B:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh1 PROTEIN (NITROGENASE
MOLYBDENUM IRON
PROTEIN)


(Klebsiella
pneumoniae)
PF00148
(Oxidored_nitro)
PF11844
(DUF3364)
5 VAL B 147
SER B 148
THR B 149
LEU B 133
VAL B 112
None
1.36A 6dryA-1qh1B:
undetectable
6dryA-1qh1B:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tc5 PROBABLE EUKARYOTIC
D-AMINO ACID TRNA
DEACYLASE,
LMAJ005534AAA


(Leishmania
major)
PF02580
(Tyr_Deacylase)
5 VAL A  64
VAL A  38
LEU A  15
PHE A 129
VAL A 133
None
1.35A 6dryA-1tc5A:
undetectable
6dryA-1tc5A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twy ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN


(Vibrio cholerae)
PF12727
(PBP_like)
5 VAL A 146
THR A 180
VAL A 108
ALA A 178
VAL A 184
None
1.35A 6dryA-1twyA:
undetectable
6dryA-1twyA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2e 2-HYDROXY-6-KETONONA
-2,4-DIENEDIOIC ACID
HYDROLASE


(Escherichia
coli)
PF12697
(Abhydrolase_6)
5 ASP A 235
VAL A 238
THR A 148
PHE A 173
GLN A 266
None
1.29A 6dryA-1u2eA:
undetectable
6dryA-1u2eA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT


(Mycobacterium
tuberculosis)
PF00268
(Ribonuc_red_sm)
5 VAL A 143
SER A 146
LEU A 166
VAL A 157
TYR A 226
None
1.35A 6dryA-1uzrA:
undetectable
6dryA-1uzrA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN


(Azotobacter
vinelandii)
PF00148
(Oxidored_nitro)
PF11844
(DUF3364)
5 SER B 150
THR B 151
LEU B 135
ALA B 155
VAL B 114
None
1.31A 6dryA-2afhB:
undetectable
6dryA-2afhB:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN


(Azotobacter
vinelandii)
PF00148
(Oxidored_nitro)
PF11844
(DUF3364)
5 VAL B 149
SER B 150
THR B 151
LEU B 135
VAL B 114
None
1.35A 6dryA-2afhB:
undetectable
6dryA-2afhB:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b34 MAR1 RIBONUCLEASE

(Caenorhabditis
elegans)
PF00857
(Isochorismatase)
5 VAL A 132
THR A 160
LEU A  17
ALA A 163
VAL A 129
None
1.29A 6dryA-2b34A:
undetectable
6dryA-2b34A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5u RNA LIGASE

(Escherichia
virus T4)
PF09511
(RNA_lig_T4_1)
5 SER A  70
LEU A 178
ALA A 150
PHE A 116
VAL A 105
None
1.31A 6dryA-2c5uA:
1.5
6dryA-2c5uA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gb3 ASPARTATE
AMINOTRANSFERASE


(Thermotoga
maritima)
PF00155
(Aminotran_1_2)
5 ASP A 228
VAL A 203
SER A 205
VAL A 241
TYR A  79
None
1.21A 6dryA-2gb3A:
undetectable
6dryA-2gb3A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gb3 ASPARTATE
AMINOTRANSFERASE


(Thermotoga
maritima)
PF00155
(Aminotran_1_2)
5 ASP A 228
VAL A 203
SER A 205
VAL A 241
TYR A  80
None
1.31A 6dryA-2gb3A:
undetectable
6dryA-2gb3A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijd PICORNAIN 3C,
RNA-DIRECTED RNA
POLYMERASE


(Enterovirus C)
PF00548
(Peptidase_C3)
PF00680
(RdRP_1)
5 VAL 1 150
LEU 1 174
ALA 1   7
VAL 1 119
TYR 1 138
None
1.21A 6dryA-2ijd1:
undetectable
6dryA-2ijd1:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE


(Porphyromonas
gingivalis)
PF04095
(NAPRTase)
5 SER A 195
THR A 194
VAL A 126
ALA A 200
TYR A  13
None
1.13A 6dryA-2im5A:
undetectable
6dryA-2im5A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2irp PUTATIVE ALDOLASE
CLASS 2 PROTEIN
AQ_1979


(Aquifex
aeolicus)
PF00596
(Aldolase_II)
5 VAL A  98
SER A  37
ALA A  19
VAL A  94
TYR A  88
None
1.36A 6dryA-2irpA:
undetectable
6dryA-2irpA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1)
PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C)
5 VAL A 512
THR A 461
VAL A 440
LEU A 439
ALA A 457
None
1.20A 6dryA-2okxA:
1.2
6dryA-2okxA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfe ALKALINE SERINE
PROTEASE


(Thermobifida
fusca)
PF00089
(Trypsin)
5 THR A 201
VAL A  47
LEU A 242
ALA A 130
VAL A 212
None
1.32A 6dryA-2pfeA:
undetectable
6dryA-2pfeA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3h RAS HOMOLOG GENE
FAMILY, MEMBER U


(Homo sapiens)
PF00071
(Ras)
5 VAL A  66
THR A  70
VAL A  55
ALA A  88
VAL A 214
None
1.13A 6dryA-2q3hA:
undetectable
6dryA-2q3hA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qu7 PUTATIVE
TRANSCRIPTIONAL
REGULATOR


(Staphylococcus
saprophyticus)
PF13407
(Peripla_BP_4)
5 VAL A 304
VAL A 160
LEU A 323
GLN A 296
VAL A  81
None
1.10A 6dryA-2qu7A:
undetectable
6dryA-2qu7A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7j 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE
-1-CARBOXYLATE
SYNTHASE


(Bacillus
subtilis)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2)
5 VAL A 101
THR A 103
VAL A  97
ALA A  82
VAL A  26
None
1.24A 6dryA-2x7jA:
undetectable
6dryA-2x7jA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
CAA3-TYPE CYTOCHROME
OXIDASE SUBUNIT IV


(Thermus
thermophilus;
Thermus
thermophilus)
PF00115
(COX1)
PF00510
(COX3)
no annotation
5 ASP A 778
VAL A 668
SER A 671
VAL A 783
VAL C  39
None
1.34A 6dryA-2yevA:
2.0
6dryA-2yevA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9k FAB HEAVY CHAIN

(Rattus rattus)
no annotation 5 VAL H 219
THR H 217
VAL H 223
ALA H 118
VAL H 154
None
1.13A 6dryA-3b9kH:
undetectable
6dryA-3b9kH:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE


(Phanerochaete
chrysosporium)
PF12708
(Pectate_lyase_3)
5 VAL A 153
VAL A 101
PHE A  89
GLN A  64
VAL A  87
None
1.14A 6dryA-3eqnA:
undetectable
6dryA-3eqnA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpk FERREDOXIN-NADP
REDUCTASE


(Salmonella
enterica)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
5 SER A  53
VAL A 140
LEU A 139
ALA A  33
TYR A 247
FAD  A 301 (-3.6A)
None
None
None
FAD  A 301 (-3.3A)
1.28A 6dryA-3fpkA:
undetectable
6dryA-3fpkA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbp GALACTOSE-BINDING
PROTEIN


(Salmonella
enterica)
PF13407
(Peripla_BP_4)
5 VAL A  68
ALA A 258
PHE A  90
GLN A  48
TYR A 107
None
1.16A 6dryA-3gbpA:
undetectable
6dryA-3gbpA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke6 PROTEIN
RV1364C/MT1410


(Mycobacterium
tuberculosis)
PF07228
(SpoIIE)
PF13581
(HATPase_c_2)
5 VAL A 170
SER A 169
VAL A 206
LEU A 205
TYR A  -6
None
1.27A 6dryA-3ke6A:
undetectable
6dryA-3ke6A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lad DIHYDROLIPOAMIDE
DEHYDROGENASE


(Azotobacter
vinelandii)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 VAL A   6
THR A  29
VAL A 310
ALA A  19
VAL A 129
None
1.35A 6dryA-3ladA:
2.3
6dryA-3ladA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mh9 LIPOPROTEIN LPRG

(Mycobacterium
tuberculosis)
no annotation 5 THR C  49
VAL C 217
LEU C 209
ALA C 147
VAL C 135
None
1.28A 6dryA-3mh9C:
undetectable
6dryA-3mh9C:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mha LIPOPROTEIN LPRG

(Mycobacterium
tuberculosis)
PF07161
(LppX_LprAFG)
5 THR A  49
VAL A 217
LEU A 209
ALA A 147
VAL A 135
None
1.28A 6dryA-3mhaA:
undetectable
6dryA-3mhaA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0d TRIACYLGLYCEROL
LIPASE


(Yarrowia
lipolytica)
PF01764
(Lipase_3)
PF03893
(Lipase3_N)
5 VAL A 158
VAL A 147
LEU A 144
ALA A 167
PHE A  59
None
None
NAG  A 302 ( 4.9A)
None
None
1.32A 6dryA-3o0dA:
undetectable
6dryA-3o0dA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk8 ENOYL-COA HYDRATASE
ECHA15


(Mycobacterium
marinum)
PF00378
(ECH_1)
5 VAL A 129
SER A 186
THR A 187
VAL A  57
LEU A  58
None
None
EDO  A 297 (-4.0A)
None
None
1.34A 6dryA-3qk8A:
1.6
6dryA-3qk8A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rkd CAPSID PROTEIN

(Orthohepevirus
A)
PF03014
(SP2)
5 VAL A 579
SER A 495
VAL A 501
LEU A 500
GLN A 508
None
1.26A 6dryA-3rkdA:
undetectable
6dryA-3rkdA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s51 FANCONI ANEMIA GROUP
I PROTEIN HOMOLOG


(Mus musculus)
PF14674
(FANCI_S1-cap)
PF14675
(FANCI_S1)
PF14676
(FANCI_S2)
PF14677
(FANCI_S3)
PF14678
(FANCI_S4)
PF14679
(FANCI_HD1)
PF14680
(FANCI_HD2)
5 VAL A 219
LEU A 218
ALA A 235
PHE A 202
VAL A 198
None
1.20A 6dryA-3s51A:
undetectable
6dryA-3s51A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t38 ARSENATE REDUCTASE

(Corynebacterium
glutamicum)
PF01451
(LMWPc)
5 ASP A 149
VAL A 150
LEU A 146
PHE A  62
TYR A  37
None
None
None
None
D1D  A3236 (-3.6A)
1.08A 6dryA-3t38A:
undetectable
6dryA-3t38A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tmq 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 2


(Burkholderia
pseudomallei)
PF00793
(DAHP_synth_1)
5 VAL A  94
THR A  92
VAL A 124
ALA A 107
VAL A 135
None
1.22A 6dryA-3tmqA:
undetectable
6dryA-3tmqA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7v BETA-GALACTOSIDASE

(Caulobacter
vibrioides)
PF02449
(Glyco_hydro_42)
5 VAL A 474
LEU A 473
ALA A 355
VAL A 489
TYR A 445
None
1.30A 6dryA-3u7vA:
undetectable
6dryA-3u7vA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB


(Pseudomonas
aeruginosa)
PF00873
(ACR_tran)
5 VAL A1027
SER A1028
THR A1029
LEU A 902
VAL A 945
None
1.22A 6dryA-3w9iA:
undetectable
6dryA-3w9iA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zv8 3C PROTEASE

(Enterovirus D)
PF00548
(Peptidase_C3)
5 VAL A 150
LEU A 174
ALA A   7
VAL A 119
TYR A 138
None
1.15A 6dryA-3zv8A:
undetectable
6dryA-3zv8A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4abn TETRATRICOPEPTIDE
REPEAT PROTEIN 5


(Mus musculus)
PF16669
(TTC5_OB)
5 VAL A 337
THR A 335
VAL A 341
LEU A 357
VAL A 417
None
1.34A 6dryA-4abnA:
2.8
6dryA-4abnA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex9 ALNA

(Streptomyces
sp. CM020)
PF04227
(Indigoidine_A)
5 SER A 155
LEU A  32
ALA A 292
PHE A 121
VAL A 106
None
None
None
None
5RP  A 402 (-4.0A)
1.36A 6dryA-4ex9A:
undetectable
6dryA-4ex9A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g68 ABC TRANSPORTER

(Caldanaerobius)
PF01547
(SBP_bac_1)
5 THR B 177
LEU B 164
ALA B 258
PHE B 150
VAL B 155
None
1.24A 6dryA-4g68B:
undetectable
6dryA-4g68B:
21.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR


(Homo sapiens)
PF00001
(7tm_1)
5 ASP A 113
VAL A 114
THR A 118
PHE A 261
TYR A 288
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 ( 4.7A)
CAU  A 500 (-4.2A)
CAU  A 500 (-4.6A)
0.84A 6dryA-4gbrA:
26.6
6dryA-4gbrA:
30.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae)
PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C)
5 VAL A  86
VAL A  69
LEU A  68
PHE A 199
VAL A 197
None
1.30A 6dryA-4gfhA:
2.7
6dryA-4gfhA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggv CYTOCHROME P450
SUPERFAMILY PROTEIN


(Streptomyces
himastatinicus)
PF00067
(p450)
5 VAL A 105
THR A 109
LEU A 351
ALA A 359
VAL A 134
None
1.32A 6dryA-4ggvA:
undetectable
6dryA-4ggvA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbc ANTIGEN BINDING
FRAGMENT,
IMMUNOGLOBULIN IGG -
HEAVY CHAIN


(Oryctolagus
cuniculus)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL H 206
THR H 204
VAL H 210
ALA H 120
VAL H 154
None
1.14A 6dryA-4hbcH:
undetectable
6dryA-4hbcH:
15.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562


(Escherichia
coli;
Homo sapiens)
PF00001
(7tm_1)
PF07361
(Cytochrom_B562)
10 ASP A 135
VAL A 136
SER A 139
THR A 140
VAL A 208
LEU A 209
ALA A 225
PHE A 340
VAL A 366
TYR A 370
ERM  A2001 (-3.2A)
ERM  A2001 (-3.8A)
ERM  A2001 (-3.6A)
ERM  A2001 (-3.9A)
ERM  A2001 (-4.0A)
ERM  A2001 (-3.7A)
ERM  A2001 (-3.4A)
ERM  A2001 (-4.3A)
ERM  A2001 ( 4.2A)
ERM  A2001 ( 4.8A)
0.41A 6dryA-4ib4A:
44.5
6dryA-4ib4A:
99.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 HEAVY
CHAIN


(Oryctolagus
cuniculus)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL H 200
THR H 198
VAL H 204
ALA H 114
VAL H 148
None
1.15A 6dryA-4jo2H:
undetectable
6dryA-4jo2H:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo3 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R20 HEAVY
CHAIN


(Oryctolagus
cuniculus)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL H 204
THR H 202
VAL H 208
ALA H 118
VAL H 152
None
1.11A 6dryA-4jo3H:
undetectable
6dryA-4jo3H:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3d BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN


(Bos taurus)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL H 206
THR H 204
VAL H 210
ALA H 118
VAL H 152
None
1.21A 6dryA-4k3dH:
undetectable
6dryA-4k3dH:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3e BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN


(Bos taurus)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL H 206
THR H 204
VAL H 210
ALA H 118
VAL H 152
None
1.07A 6dryA-4k3eH:
undetectable
6dryA-4k3eH:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvl FATTY ACID
ALPHA-OXIDASE


(Oryza sativa)
PF03098
(An_peroxidase)
5 ASP A  36
THR A 547
VAL A  10
LEU A  14
TYR A  52
None
1.28A 6dryA-4kvlA:
0.7
6dryA-4kvlA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR


(Homo sapiens;
Escherichia
virus T4)
PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
5 ASP A1113
VAL A1114
THR A1118
PHE A1289
TYR A1316
P0G  A1401 (-2.9A)
P0G  A1401 (-3.7A)
None
P0G  A1401 ( 4.7A)
None
0.47A 6dryA-4ldeA:
27.0
6dryA-4ldeA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o94 TRAP DICARBOXYLATE
TRANSPORTER DCTP
SUBUNIT


(Rhodopseudomonas
palustris)
PF03480
(DctP)
5 VAL A  60
THR A  56
VAL A  85
ALA A 255
PHE A  48
None
1.15A 6dryA-4o94A:
undetectable
6dryA-4o94A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4piv FATTY ACID SYNTHASE

(Homo sapiens)
PF08242
(Methyltransf_12)
PF08659
(KR)
5 VAL A1245
LEU A1342
ALA A1303
VAL A1242
TYR A1270
None
1.08A 6dryA-4pivA:
undetectable
6dryA-4pivA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjl PHOSPHOPANTETHEINYL
TRANSFERASE, PPTII


(Mycobacterium
ulcerans)
PF01648
(ACPS)
5 THR A  92
VAL A  15
LEU A  11
ALA A 115
VAL A 162
COA  A 301 (-3.6A)
None
None
None
None
1.23A 6dryA-4qjlA:
undetectable
6dryA-4qjlA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qme AMINOPEPTIDASE N

(Neisseria
meningitidis)
PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C)
5 VAL A  34
THR A  92
LEU A 185
ALA A  55
PHE A 121
None
1.25A 6dryA-4qmeA:
undetectable
6dryA-4qmeA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9g MBP1

(Caldanaerobius
polysaccharolyticus)
PF13416
(SBP_bac_8)
5 ASP A  89
VAL A 196
LEU A 303
GLN A 191
TYR A  85
ZN  A 505 (-3.0A)
None
None
BMA  A 502 (-3.7A)
None
1.35A 6dryA-4r9gA:
undetectable
6dryA-4r9gA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rot ESTERASE A

(Streptococcus
pyogenes)
PF00756
(Esterase)
5 THR A 195
VAL A 245
LEU A 246
ALA A 133
GLN A 242
None
1.35A 6dryA-4rotA:
undetectable
6dryA-4rotA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9s PHOSPHORIBOSYL
ISOMERASE A


(Streptomyces
sp. Mg1)
PF00977
(His_biosynth)
5 VAL A  54
SER A  83
VAL A 223
ALA A  59
VAL A 166
SO4  A 305 (-4.8A)
SO4  A 301 ( 4.4A)
SO4  A 303 ( 4.7A)
SO4  A 301 (-3.4A)
None
1.34A 6dryA-4x9sA:
undetectable
6dryA-4x9sA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbi CLPB PROTEIN,
PUTATIVE,GREEN
FLUORESCENT PROTEIN


(Plasmodium
falciparum;
Aequorea
victoria)
PF01353
(GFP)
PF02861
(Clp_N)
5 VAL A  93
SER A  97
THR A  96
VAL A  30
TYR A   7
None
1.31A 6dryA-4xbiA:
undetectable
6dryA-4xbiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcg THERMOSOME SUBUNIT
BETA


(Sulfolobus
solfataricus)
PF00118
(Cpn60_TCP1)
5 VAL B 372
LEU B 333
ALA B 246
GLN B 303
VAL B 322
None
1.27A 6dryA-4xcgB:
undetectable
6dryA-4xcgB:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yio SUPEROXIDE DISMUTASE

(Streptococcus
thermophilus)
PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C)
5 VAL A  98
THR A  95
VAL A 141
LEU A 131
PHE A 109
None
1.25A 6dryA-4yioA:
undetectable
6dryA-4yioA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yip SUPEROXIDE DISMUTASE
[MN/FE]


(Streptococcus
mutans)
PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C)
5 VAL A  98
THR A  95
VAL A 141
LEU A 131
PHE A 109
None
1.24A 6dryA-4yipA:
undetectable
6dryA-4yipA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztp HEAVY CHAIN OF FAB
FRAGMENT OF RABBIT
MONOCLONAL ANTIBODY
R53


(Oryctolagus
cuniculus)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL H 203
THR H 201
VAL H 207
ALA H 117
VAL H 151
None
1.08A 6dryA-4ztpH:
undetectable
6dryA-4ztpH:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bpe EV71 3CPRO

(Enterovirus A)
PF00548
(Peptidase_C3)
5 VAL A 150
LEU A 174
ALA A   7
VAL A 119
TYR A 138
None
1.14A 6dryA-5bpeA:
undetectable
6dryA-5bpeA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5diy HYALURONIDASE

(Thermobaculum
terrenum)
PF07555
(NAGidase)
5 VAL A 448
SER A 451
THR A 452
LEU A 347
PHE A 397
None
1.09A 6dryA-5diyA:
undetectable
6dryA-5diyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE


(Symbiobacterium
thermophilum)
PF00282
(Pyridoxal_deC)
5 VAL A 164
SER A 320
THR A 319
VAL A 160
ALA A 362
None
1.28A 6dryA-5eueA:
undetectable
6dryA-5eueA:
21.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR


(Meleagris
gallopavo)
no annotation 5 ASP B 121
VAL B 122
THR B 126
PHE B 306
TYR B 333
P32  B 400 (-2.2A)
P32  B 400 (-3.5A)
None
P32  B 400 (-4.1A)
P32  B 400 (-4.6A)
0.81A 6dryA-5f8uB:
26.9
6dryA-5f8uB:
30.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4q DNA POLYMERASE III
SUBUNIT BETA


(Helicobacter
pylori)
PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3)
5 VAL A 170
THR A 181
LEU A 204
ALA A 363
VAL A 144
None
1.35A 6dryA-5g4qA:
undetectable
6dryA-5g4qA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8k HHH1 FAB LIGHT CHAIN

(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL L  11
SER L  10
THR L 105
VAL L  15
LEU L  80
None
1.21A 6dryA-5i8kL:
undetectable
6dryA-5i8kL:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihu BOVINE FAB B11 HEAVY
CHAIN


(Bos taurus)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL H 261
THR H 259
VAL H 265
ALA H 173
VAL H 207
None
1.06A 6dryA-5ihuH:
undetectable
6dryA-5ihuH:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijv BOVINE FAB E03 HEAVY
CHAIN


(Bos taurus)
no annotation 5 VAL H 242
THR H 240
VAL H 246
ALA H 154
VAL H 188
None
1.04A 6dryA-5ijvH:
undetectable
6dryA-5ijvH:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilt BOVINE FAB A01 HEAVY
CHAIN


(Bos taurus)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL H 259
THR H 257
VAL H 263
ALA H 171
VAL H 205
None
1.08A 6dryA-5iltH:
undetectable
6dryA-5iltH:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j8q CYSTEINE DESULFURASE
SUFS


(Bacillus
subtilis)
PF00266
(Aminotran_5)
5 VAL A 171
SER A 169
VAL A 332
LEU A 331
ALA A 200
None
None
None
None
PLP  A 501 (-3.5A)
1.30A 6dryA-5j8qA:
undetectable
6dryA-5j8qA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxu DYP-TYPE PEROXIDASE
FAMILY


(Thermomonospora
curvata)
PF04261
(Dyp_perox)
5 THR A  62
VAL A 252
LEU A 251
ALA A  58
VAL A 236
None
1.34A 6dryA-5jxuA:
undetectable
6dryA-5jxuA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kte DIVALENT METAL
CATION TRANSPORTER
MNTH


(Deinococcus
radiodurans)
PF01566
(Nramp)
5 THR A 228
VAL A 390
LEU A 389
ALA A  81
VAL A 420
None
1.35A 6dryA-5kteA:
undetectable
6dryA-5kteA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m23 WD REPEAT-CONTAINING
PROTEIN 5


(Homo sapiens)
PF00400
(WD40)
5 ASP A  92
SER A  50
VAL A 145
ALA A 308
PHE A 219
7DC  A 401 ( 4.3A)
None
None
None
None
1.32A 6dryA-5m23A:
undetectable
6dryA-5m23A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m28 MALE1

(Lactobacillus
casei)
PF13416
(SBP_bac_8)
5 ASP A 189
VAL A 190
SER A 192
LEU A 177
ALA A 198
None
1.27A 6dryA-5m28A:
undetectable
6dryA-5m28A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m63 H CHAIN OF FAB
NVS-1-19-5


(Oryctolagus
cuniculus)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL H 235
THR H 233
VAL H 239
ALA H 149
VAL H 183
None
1.07A 6dryA-5m63H:
undetectable
6dryA-5m63H:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofk GLYCOSIDE HYDROLASE
FAMILY 48


(Caldicellulosiruptor
bescii)
PF00331
(Glyco_hydro_10)
5 THR A 282
LEU A 249
ALA A 335
PHE A  16
VAL A 291
None
1.19A 6dryA-5ofkA:
undetectable
6dryA-5ofkA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B


(Spodoptera
frugiperda;
Homo sapiens)
no annotation 5 ASP A 129
THR A 134
ALA A 216
PHE A 330
TYR A 359
89F  A1201 (-3.3A)
89F  A1201 (-4.2A)
89F  A1201 ( 3.9A)
89F  A1201 (-4.1A)
None
0.69A 6dryA-5v54A:
33.8
6dryA-5v54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6l HEAVY CHAIN OF FAB
FRAGMENT OF RABBIT
ANTI-HIV1 GP120 V3
MAB 10A37


(Oryctolagus
cuniculus)
no annotation 5 VAL H 204
THR H 202
VAL H 208
ALA H 118
VAL H 152
None
1.16A 6dryA-5v6lH:
undetectable
6dryA-5v6lH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgb CRISPR-ASSOCIATED
ENDONUCLEASE CAS9


(Neisseria
meningitidis)
PF13395
(HNH_4)
5 SER A  37
VAL A  93
LEU A  92
ALA A  20
PHE A  87
None
1.17A 6dryA-5vgbA:
undetectable
6dryA-5vgbA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voh NADH OXIDASE

(Lactobacillus
brevis)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 VAL A 108
THR A 110
VAL A 312
LEU A 311
ALA A  11
None
None
None
None
FAD  A 501 (-3.2A)
1.10A 6dryA-5vohA:
undetectable
6dryA-5vohA:
23.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA


(Escherichia
coli;
Homo sapiens)
no annotation 6 ASP A 115
VAL A 116
THR A 120
LEU A 187
PHE A 410
TYR A 438
AQD  A1201 (-3.3A)
AQD  A1201 ( 3.9A)
AQD  A1201 (-4.4A)
AQD  A1201 (-4.5A)
AQD  A1201 (-4.7A)
None
0.84A 6dryA-5wivA:
30.8
6dryA-5wivA:
50.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E


(Pseudomonas sp.
AIU 813)
no annotation 5 ASP A  21
THR A 513
LEU A 188
VAL A 196
TYR A 481
None
1.25A 6dryA-5yb7A:
undetectable
6dryA-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arr ACETYL-COA
ACETYLTRANSFERASE


(Aspergillus
fumigatus)
no annotation 5 ASP A 222
VAL A  17
THR A  15
VAL A 350
ALA A 259
None
None
None
CS  A 402 (-4.6A)
None
1.13A 6dryA-6arrA:
undetectable
6dryA-6arrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10


(Homo sapiens)
no annotation 5 VAL A 385
VAL A 272
LEU A 224
ALA A 331
PHE A 318
None
1.35A 6dryA-6bdzA:
undetectable
6dryA-6bdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562


(Escherichia
coli;
Homo sapiens)
no annotation 9 ASP A 134
VAL A 135
SER A 138
THR A 139
LEU A 209
ALA A 222
PHE A 327
VAL A 354
TYR A 358
E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.3A)
None
E2J  A1201 ( 3.8A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.6A)
None
0.88A 6dryA-6bqhA:
31.5
6dryA-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562


(Escherichia
coli;
Homo sapiens)
no annotation 7 ASP A 134
VAL A 135
SER A 138
THR A 139
VAL A 208
LEU A 209
ALA A 222
E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.3A)
None
None
E2J  A1201 ( 3.8A)
0.87A 6dryA-6bqhA:
31.5
6dryA-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
MBH13 NADH
DEHYDROGENASE
SUBUNIT


(Pyrococcus
furiosus;
Pyrococcus
furiosus)
no annotation
no annotation
5 VAL M 116
SER M 120
LEU H 391
ALA M  71
PHE M  66
None
1.36A 6dryA-6cfwM:
2.5
6dryA-6cfwM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B


(Homo sapiens)
no annotation 5 ASP S 129
THR S 134
ALA S 216
PHE S 330
TYR S 359
EP5  S 401 (-3.3A)
EP5  S 401 (-3.8A)
EP5  S 401 ( 4.0A)
EP5  S 401 (-4.0A)
EP5  S 401 ( 4.9A)
0.45A 6dryA-6g79S:
26.5
6dryA-6g79S:
undetectable