SIMILAR PATTERNS OF AMINO ACIDS FOR 6DM2_D_CYZD1302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czf POLYGALACTURONASE II

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		5 PRO A  88
SER A 153
SER A  93
LEU A 134
ASP A 135
 None
 1.09A 6dm2A-1czfA:
undetectable
6dm2D-1czfA:
undetectable		 6dm2A-1czfA:
11.60
6dm2D-1czfA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgs DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		5 ILE A 153
PRO A 250
LEU A 123
SER A 121
LEU A 120
 None
None
None
None
AMP  A 700 ( 4.7A)
 1.19A 6dm2A-1dgsA:
3.0
6dm2D-1dgsA:
2.9		 6dm2A-1dgsA:
7.75
6dm2D-1dgsA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj2 ADENYLOSUCCINATE
SYNTHETASE

(Arabidopsis
thaliana) 		PF00709
(Adenylsucc_synt) 		5 ILE A 152
SER A 157
LEU A 125
LEU A 183
ASP A 186
 None
 1.49A 6dm2A-1dj2A:
undetectable
6dm2D-1dj2A:
undetectable		 6dm2A-1dj2A:
14.29
6dm2D-1dj2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3l PROTEIN ARGININE
METHYLTRANSFERASE
PRMT3

(Rattus
norvegicus) 		PF06325
(PrmA) 		5 ILE A 454
PRO A 357
LEU A 332
LEU A 429
ASP A 428
 None
 1.42A 6dm2A-1f3lA:
undetectable
6dm2D-1f3lA:
undetectable		 6dm2A-1f3lA:
14.64
6dm2D-1f3lA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1peg HISTONE H3
METHYLTRANSFERASE
DIM-5

(Neurospora
crassa) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 ILE A 183
SER A  49
SER A 234
LEU A 265
ASP A 264
 None
 1.35A 6dm2A-1pegA:
undetectable
6dm2D-1pegA:
undetectable		 6dm2A-1pegA:
13.67
6dm2D-1pegA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdm PROPHYTEPSIN

(Hordeum vulgare) 		PF00026
(Asp)
PF03489
(SapB_2)
PF05184
(SapB_1) 		5 ILE A  22
SER A  93
SER A  66
LEU A  42
ASP A 103
 None
 1.34A 6dm2A-1qdmA:
undetectable
6dm2D-1qdmA:
undetectable		 6dm2A-1qdmA:
10.35
6dm2D-1qdmA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4c PROTEIN HI0227

(Haemophilus
influenzae) 		PF04074
(DUF386) 		5 ILE A 143
PRO A  52
LEU A  74
LEU A  31
ASP A  30
 None
 1.34A 6dm2A-1s4cA:
undetectable
6dm2D-1s4cA:
undetectable		 6dm2A-1s4cA:
14.94
6dm2D-1s4cA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkf GLYCEROL UPTAKE
OPERON
ANTITERMINATOR-RELAT
ED PROTEIN

(Thermotoga
maritima) 		PF04309
(G3P_antiterm) 		5 ILE A  18
PRO A  20
SER A 165
LEU A  40
LEU A  26
 None
None
CIT  A 501 (-2.6A)
None
CIT  A 501 (-4.9A)
 1.49A 6dm2A-1vkfA:
2.3
6dm2D-1vkfA:
undetectable		 6dm2A-1vkfA:
17.11
6dm2D-1vkfA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae) 		PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		5 ILE C 109
LEU C 128
LEU C 212
ASP C 215
LYS C 211
 None
 1.30A 6dm2A-1wa5C:
undetectable
6dm2D-1wa5C:
3.4		 6dm2A-1wa5C:
6.01
6dm2D-1wa5C:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xq9 PHOSPHOGLYCERATE
MUTASE

(Plasmodium
falciparum) 		PF00300
(His_Phos_1) 		5 PRO A 130
LEU A 103
SER A 102
LEU A 134
ASP A 135
 None
 1.39A 6dm2A-1xq9A:
undetectable
6dm2D-1xq9A:
3.9		 6dm2A-1xq9A:
13.62
6dm2D-1xq9A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zt2 DNA PRIMASE LARGE
SUBUNIT

(Sulfolobus
solfataricus) 		PF04104
(DNA_primase_lrg) 		5 ILE B 199
PRO B 200
LEU B  72
LEU B  18
ASP B  15
 None
SO4  B 218 (-4.0A)
None
None
None
 1.27A 6dm2A-1zt2B:
undetectable
6dm2D-1zt2B:
2.2		 6dm2A-1zt2B:
15.08
6dm2D-1zt2B:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3q GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		5 ILE A 152
PRO A 196
SER A  86
LEU A 201
SER A  72
 None
 1.48A 6dm2A-2b3qA:
undetectable
6dm2D-2b3qA:
undetectable		 6dm2A-2b3qA:
14.81
6dm2D-2b3qA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cso PLECKSTRIN

(Homo sapiens) 		PF00610
(DEP) 		5 ILE A  32
SER A  62
LEU A  82
LEU A  18
ASP A  17
 None
 1.39A 6dm2A-2csoA:
undetectable
6dm2D-2csoA:
undetectable		 6dm2A-2csoA:
18.60
6dm2D-2csoA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF01368
(DHH)
PF02833
(DHHA2) 		5 ILE A  19
PRO A  51
SER A  14
LEU A 139
ASP A 147
 None
None
MN  A 501 ( 3.7A)
None
MN  A 502 (-2.6A)
 1.05A 6dm2A-2eb0A:
undetectable
6dm2D-2eb0A:
undetectable		 6dm2A-2eb0A:
12.96
6dm2D-2eb0A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE

(Bacillus sp.
NG-27) 		PF00331
(Glyco_hydro_10) 		5 ILE A 231
PRO A 236
SER A 244
LEU A 294
LEU A 301
 None
 1.45A 6dm2A-2f8qA:
undetectable
6dm2D-2f8qA:
undetectable		 6dm2A-2f8qA:
11.11
6dm2D-2f8qA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g16 GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		5 ILE B 152
PRO B 196
SER B  86
LEU B 201
SER B  72
 None
 1.50A 6dm2A-2g16B:
undetectable
6dm2D-2g16B:
undetectable		 6dm2A-2g16B:
18.45
6dm2D-2g16B:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum) 		PF00440
(TetR_N) 		5 ILE A 156
SER A 130
LEU A 160
LEU A  74
ASP A  71
 None
None
EDO  A 197 ( 4.8A)
EDO  A 197 ( 3.9A)
None
 1.21A 6dm2A-2hytA:
undetectable
6dm2D-2hytA:
2.1		 6dm2A-2hytA:
14.78
6dm2D-2hytA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei) 		PF00686
(CBM_20)
PF00723
(Glyco_hydro_15) 		5 ILE A 158
SER A 152
LEU A 135
SER A 139
LEU A 142
 None
 1.27A 6dm2A-2vn7A:
3.1
6dm2D-2vn7A:
2.6		 6dm2A-2vn7A:
11.75
6dm2D-2vn7A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN

(Aquifex
aeolicus) 		PF01867
(Cas_Cas1) 		5 SER A 203
SER A 209
LEU A 190
SER A 216
LEU A 217
 None
 1.30A 6dm2A-2yzsA:
undetectable
6dm2D-2yzsA:
undetectable		 6dm2A-2yzsA:
12.70
6dm2D-2yzsA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT
MEMBRANE-BOUND
HYDROGENASE SMALL
SUBUNIT

(Hydrogenovibrio
marinus;
Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 ILE A 171
PRO A 134
MET B  55
LEU B  43
ASP B  49
 None
 1.12A 6dm2A-3ayxA:
undetectable
6dm2D-3ayxA:
5.2		 6dm2A-3ayxA:
8.84
6dm2D-3ayxA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc1 PUTATIVE
ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bacillus
halodurans) 		PF16499
(Melibiase_2) 		5 ILE A 416
SER A 413
LEU A 426
LEU A 385
ASP A 386
 None
 1.20A 6dm2A-3cc1A:
undetectable
6dm2D-3cc1A:
undetectable		 6dm2A-3cc1A:
10.50
6dm2D-3cc1A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 ILE A  65
PRO A 109
SER A 244
LEU A 114
SER A 230
 None
 1.50A 6dm2A-3evrA:
undetectable
6dm2D-3evrA:
undetectable		 6dm2A-3evrA:
12.35
6dm2D-3evrA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6t GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		5 MET A 107
SER A 108
LEU A 239
LEU A 247
LYS A 251
 None
CYZ  A 265 (-2.8A)
CYZ  A 265 (-4.7A)
CYZ  A 265 (-4.3A)
CYZ  A 265 ( 4.4A)
 0.76A 6dm2A-3h6tA:
29.1
6dm2D-3h6tA:
35.9		 6dm2A-3h6tA:
15.44
6dm2D-3h6tA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8l NADH OXIDASE

(Acidianus
ambivalens) 		PF07992
(Pyr_redox_2) 		5 ILE A 288
MET A  87
SER A  86
LEU A 274
SER A 277
 None
 1.07A 6dm2A-3h8lA:
2.3
6dm2D-3h8lA:
3.9		 6dm2A-3h8lA:
11.93
6dm2D-3h8lA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hul HOMOSERINE KINASE

(Listeria
monocytogenes) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 ILE A 159
PRO A 160
SER A 219
LEU A  84
SER A 243
 None
 1.46A 6dm2A-3hulA:
undetectable
6dm2D-3hulA:
undetectable		 6dm2A-3hulA:
13.45
6dm2D-3hulA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		5 ILE A  73
LEU A  48
SER A  52
LEU A 114
LYS A 118
 None
 1.44A 6dm2A-3hveA:
undetectable
6dm2D-3hveA:
undetectable		 6dm2A-3hveA:
12.80
6dm2D-3hveA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icq EXPORTIN-T

(Schizosaccharomyces
pombe) 		PF08389
(Xpo1) 		5 ILE T 423
SER T 380
SER T 340
LEU T 358
LEU T 335
 None
 1.49A 6dm2A-3icqT:
2.2
6dm2D-3icqT:
2.2		 6dm2A-3icqT:
6.07
6dm2D-3icqT:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4u MAJOR CAPSID PROTEIN

(Bordetella
virus BPP1) 		no annotation 5 ILE A 315
PRO A 316
MET A  42
LEU A 175
LEU A 183
 None
 1.47A 6dm2A-3j4uA:
undetectable
6dm2D-3j4uA:
undetectable		 6dm2A-3j4uA:
12.65
6dm2D-3j4uA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jro FUSION PROTEIN OF
PROTEIN TRANSPORT
PROTEIN SEC13 AND
NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12110
(Nup96) 		5 ILE A1533
PRO A1209
LEU A1492
LEU A1191
ASP A1192
 None
 1.48A 6dm2A-3jroA:
2.2
6dm2D-3jroA:
undetectable		 6dm2A-3jroA:
9.28
6dm2D-3jroA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzu PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		5 ILE A 739
PRO A 786
SER A 701
LEU A 838
ASP A 837
 None
 1.37A 6dm2A-3nzuA:
undetectable
6dm2D-3nzuA:
undetectable		 6dm2A-3nzuA:
7.54
6dm2D-3nzuA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ol2 SEMAPHORIN-4D

(Homo sapiens) 		PF00047
(ig)
PF01403
(Sema)
PF01437
(PSI) 		5 ILE A 460
SER A 442
LEU A 413
LEU A 312
ASP A 295
 None
 1.33A 6dm2A-3ol2A:
undetectable
6dm2D-3ol2A:
undetectable		 6dm2A-3ol2A:
8.63
6dm2D-3ol2A:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osr MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Escherichia
coli;
Aequorea
victoria) 		PF01353
(GFP)
PF01547
(SBP_bac_1) 		5 ILE A 319
PRO A 363
SER A 498
LEU A 368
SER A 484
 None
 1.47A 6dm2A-3osrA:
4.6
6dm2D-3osrA:
6.7		 6dm2A-3osrA:
7.63
6dm2D-3osrA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p28 GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		5 ILE A 104
PRO A 148
SER A  38
LEU A 153
SER A  24
 None
 1.47A 6dm2A-3p28A:
undetectable
6dm2D-3p28A:
undetectable		 6dm2A-3p28A:
15.64
6dm2D-3p28A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Francisella
tularensis) 		PF00342
(PGI) 		5 ILE A 272
PRO A 152
SER A 267
LEU A 284
LEU A  91
 None
 1.48A 6dm2A-3q88A:
undetectable
6dm2D-3q88A:
undetectable		 6dm2A-3q88A:
9.93
6dm2D-3q88A:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli;
Escherichia
coli) 		no annotation
no annotation 		5 ILE N 132
SER N 168
SER K  42
LEU N 214
LEU N 209
 None
 1.43A 6dm2A-3rkoN:
4.4
6dm2D-3rkoN:
3.6		 6dm2A-3rkoN:
10.46
6dm2D-3rkoN:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u8p CYTOCHROME B562
INTEGRAL FUSION WITH
ENHANCED GREEN
FLUORESCENT PROTEIN

(Escherichia
coli;
Aequorea
victoria) 		PF01353
(GFP)
PF07361
(Cytochrom_B562) 		5 ILE A 260
PRO A 304
SER A 194
LEU A 309
SER A 180
 None
 1.44A 6dm2A-3u8pA:
6.2
6dm2D-3u8pA:
5.0		 6dm2A-3u8pA:
13.66
6dm2D-3u8pA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
halstedii) 		PF00501
(AMP-binding) 		5 ILE A 334
PRO A 336
LEU A 351
SER A 208
LEU A  25
 None
 1.47A 6dm2A-3wv4A:
5.3
6dm2D-3wv4A:
5.3		 6dm2A-3wv4A:
15.05
6dm2D-3wv4A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvi TYPE-2 RESTRICTION
ENZYME HINDIII

(Haemophilus
influenzae) 		PF09518
(RE_HindIII) 		5 PRO A 149
LEU A 166
SER A 159
LEU A 160
ASP A 161
 None
 1.45A 6dm2A-3wviA:
undetectable
6dm2D-3wviA:
undetectable		 6dm2A-3wviA:
15.85
6dm2D-3wviA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
halstedii) 		PF00501
(AMP-binding) 		5 ILE A 334
PRO A 336
LEU A 351
SER A 208
LEU A  25
 None
 1.48A 6dm2A-3wvnA:
4.7
6dm2D-3wvnA:
5.5		 6dm2A-3wvnA:
9.71
6dm2D-3wvnA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4u BIFUNCTIONAL PROTEIN
FOLD

(Acinetobacter
baumannii) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 ILE A 104
PRO A 101
SER A  46
LEU A  78
ASP A 120
 None
 1.42A 6dm2A-4b4uA:
4.7
6dm2D-4b4uA:
4.6		 6dm2A-4b4uA:
12.87
6dm2D-4b4uA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxs VENOM PROTHROMBIN
ACTIVATOR
PSEUTARIN-C
NON-CATALYTIC
SUBUNIT

(Pseudonaja
textilis) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		5 ILE V 299
SER V 272
LEU V 297
LEU V 249
ASP V 270
 None
 1.45A 6dm2A-4bxsV:
undetectable
6dm2D-4bxsV:
undetectable		 6dm2A-4bxsV:
4.95
6dm2D-4bxsV:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcg UNCHARACTERIZED
PROTEIN

(Xanthomonas
euvesicatoria) 		PF13855
(LRR_8) 		5 ILE A 268
PRO A 289
SER A 323
LEU A 277
LEU A 330
 None
None
CL  A 503 (-2.9A)
None
None
 0.85A 6dm2A-4fcgA:
undetectable
6dm2D-4fcgA:
undetectable		 6dm2A-4fcgA:
15.54
6dm2D-4fcgA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqf CST COMPLEX SUBUNIT
STN1

(Homo sapiens) 		PF09170
(STN1_2) 		5 ILE A 308
SER A 334
LEU A 351
LEU A 300
ASP A 299
 None
 1.49A 6dm2A-4jqfA:
undetectable
6dm2D-4jqfA:
undetectable		 6dm2A-4jqfA:
21.88
6dm2D-4jqfA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mf4 HPCH/HPAI
ALDOLASE/CITRATE
LYASE FAMILY PROTEIN

(Burkholderia
cenocepacia) 		PF03328
(HpcH_HpaI) 		5 ILE A 169
MET A 204
SER A 159
LEU A 185
ASP A 184
 None
None
None
None
EDO  A 301 (-4.0A)
 1.47A 6dm2A-4mf4A:
2.0
6dm2D-4mf4A:
undetectable		 6dm2A-4mf4A:
14.45
6dm2D-4mf4A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 ILE A 567
PRO A 592
SER A 597
LEU A 582
LEU A 577
 None
 1.42A 6dm2A-4mn8A:
undetectable
6dm2D-4mn8A:
undetectable		 6dm2A-4mn8A:
6.72
6dm2D-4mn8A:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 ILE A 567
PRO A 592
SER A 597
LEU A 582
LEU A 577
 None
 1.35A 6dm2A-4mnaA:
undetectable
6dm2D-4mnaA:
undetectable		 6dm2A-4mnaA:
7.51
6dm2D-4mnaA:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nd4 LACTATE
DEHYDROGENASE,
ADJACENT GENE
ENCODES PREDICTED
MALATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A 192
PRO A 290
SER A 188
LEU A 307
SER A 204
 None
 1.45A 6dm2A-4nd4A:
2.2
6dm2D-4nd4A:
5.7		 6dm2A-4nd4A:
15.41
6dm2D-4nd4A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfe GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria;
Vicugna pacos) 		PF01353
(GFP)
PF07686
(V-set) 		5 ILE A 152
PRO A 196
SER A  86
LEU A 201
SER A  72
 None
 1.48A 6dm2A-4pfeA:
undetectable
6dm2D-4pfeA:
undetectable		 6dm2A-4pfeA:
13.89
6dm2D-4pfeA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzh LIC12234

(Leptospira
interrogans) 		PF13855
(LRR_8) 		5 ILE A  84
PRO A  81
LEU A  87
LEU A  47
ASP A  48
 None
None
None
None
CL  A 306 ( 4.1A)
 1.35A 6dm2A-4tzhA:
undetectable
6dm2D-4tzhA:
undetectable		 6dm2A-4tzhA:
18.02
6dm2D-4tzhA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u08 LIC11098

(Leptospira
interrogans) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 ILE A 390
PRO A 387
LEU A 393
LEU A 353
ASP A 354
 None
 1.47A 6dm2A-4u08A:
undetectable
6dm2D-4u08A:
undetectable		 6dm2A-4u08A:
13.20
6dm2D-4u08A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u09 LIC12759

(Leptospira
interrogans) 		PF13855
(LRR_8) 		5 ILE A 221
PRO A 218
LEU A 224
LEU A 184
ASP A 185
 None
 1.41A 6dm2A-4u09A:
undetectable
6dm2D-4u09A:
undetectable		 6dm2A-4u09A:
8.64
6dm2D-4u09A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 ILE A 379
PRO A 407
LEU A 397
LEU A 392
LYS A 390
 None
 1.34A 6dm2A-4z64A:
undetectable
6dm2D-4z64A:
undetectable		 6dm2A-4z64A:
8.88
6dm2D-4z64A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zf4 GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		5 ILE A 102
PRO A 146
SER A  36
LEU A 151
SER A  22
 None
 1.45A 6dm2A-4zf4A:
undetectable
6dm2D-4zf4A:
undetectable		 6dm2A-4zf4A:
16.27
6dm2D-4zf4A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwn MONOGLYCERIDE LIPASE

(Saccharomyces
cerevisiae) 		PF12146
(Hydrolase_4) 		5 ILE A  55
SER A 123
LEU A 286
SER A 282
ASP A 251
 None
 1.33A 6dm2A-4zwnA:
undetectable
6dm2D-4zwnA:
3.3		 6dm2A-4zwnA:
12.58
6dm2D-4zwnA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxk SIALIDASE A

(Streptococcus
pneumoniae) 		PF02973
(Sialidase) 		5 ILE A 269
SER A 140
SER A 174
LEU A 289
LEU A 146
 None
 1.37A 6dm2A-4zxkA:
undetectable
6dm2D-4zxkA:
undetectable		 6dm2A-4zxkA:
15.03
6dm2D-4zxkA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bym SUPPRESSOR PROTEIN
MPT5

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		5 ILE A 257
LEU A 302
SER A 293
LEU A 335
ASP A 338
 None
 1.43A 6dm2A-5bymA:
undetectable
6dm2D-5bymA:
undetectable		 6dm2A-5bymA:
9.73
6dm2D-5bymA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
BETA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		PF02239
(Cytochrom_D1) 		5 ILE B 157
PRO B 178
SER B 174
SER B 203
LEU B 190
 None
 1.40A 6dm2A-5c2vB:
undetectable
6dm2D-5c2vB:
undetectable		 6dm2A-5c2vB:
12.50
6dm2D-5c2vB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 ILE D 198
SER D 337
LEU D 186
LEU D 360
ASP D 361
 None
 1.25A 6dm2A-5fl7D:
4.2
6dm2D-5fl7D:
3.0		 6dm2A-5fl7D:
9.77
6dm2D-5fl7D:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 ILE B 341
PRO B 362
SER B 388
LEU B 350
LEU B 395
 None
 1.30A 6dm2A-5gqrB:
undetectable
6dm2D-5gqrB:
undetectable		 6dm2A-5gqrB:
8.32
6dm2D-5gqrB:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
PF01194
(RNA_pol_N) 		5 ILE C  46
SER C 237
LEU C 118
SER C 115
ASP J  16
 None
 1.39A 6dm2A-5ip7C:
undetectable
6dm2D-5ip7C:
undetectable		 6dm2A-5ip7C:
14.29
6dm2D-5ip7C:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 ILE A 447
PRO A 468
SER A 494
LEU A 456
LEU A 501
 None
 1.18A 6dm2A-5ixqA:
undetectable
6dm2D-5ixqA:
undetectable		 6dm2A-5ixqA:
8.44
6dm2D-5ixqA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j3n GREEN FLUORESCENT
PROTEIN,HSDR

(Escherichia
coli;
Aequorea
victoria) 		PF01353
(GFP)
PF12008
(EcoR124_C) 		5 ILE A 158
PRO A 202
SER A  92
LEU A 207
SER A  78
 None
 1.48A 6dm2A-5j3nA:
2.8
6dm2D-5j3nA:
2.9		 6dm2A-5j3nA:
11.08
6dm2D-5j3nA:
11.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 MET A 496
LEU A 751
LEU A 759
ASP A 760
LYS A 763
 None
 0.84A 6dm2A-5l1bA:
41.9
6dm2D-5l1bA:
40.1		 6dm2A-5l1bA:
100.00
6dm2D-5l1bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 MET A 496
LEU A 751
SER A 754
LEU A 759
LYS A 763
 None
 0.97A 6dm2A-5l1bA:
41.9
6dm2D-5l1bA:
40.1		 6dm2A-5l1bA:
100.00
6dm2D-5l1bA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2n ELONGATOR COMPLEX
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 ILE A 755
PRO A 751
LEU A 758
SER A 721
LEU A 731
 None
 1.33A 6dm2A-5m2nA:
undetectable
6dm2D-5m2nA:
undetectable		 6dm2A-5m2nA:
9.00
6dm2D-5m2nA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		5 ILE A 260
LEU A 133
LEU A 148
ASP A 149
LYS A 152
 None
 1.45A 6dm2A-5m8tA:
undetectable
6dm2D-5m8tA:
undetectable		 6dm2A-5m8tA:
10.31
6dm2D-5m8tA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mbg BETA SUBUNIT OF
PHOTOACTIVATED
ADENYLYL CYCLASE

(Beggiatoa sp.
PS) 		PF00211
(Guanylate_cyc) 		5 ILE A 152
LEU A 248
SER A 219
LEU A 220
ASP A 221
 None
 1.30A 6dm2A-5mbgA:
undetectable
6dm2D-5mbgA:
undetectable		 6dm2A-5mbgA:
17.82
6dm2D-5mbgA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjf ALLOPHYCOCYANIN
ALPHA SUBUNIT
ALLOPHYCOCYANIN BETA
SUBUNIT

(Gracilaria
chilensis;
Gracilaria
chilensis) 		PF00502
(Phycobilisome)
PF00502
(Phycobilisome) 		5 ILE B   9
PRO A 103
LEU B  19
LEU A  89
ASP A  86
 None
 1.35A 6dm2A-5tjfB:
undetectable
6dm2D-5tjfB:
undetectable		 6dm2A-5tjfB:
19.15
6dm2D-5tjfB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqr POLYCOMB PROTEIN EED

(Chaetomium
thermophilum) 		PF00400
(WD40) 		5 PRO A  47
LEU A 111
SER A  98
LEU A 144
ASP A 143
 None
 1.33A 6dm2A-5tqrA:
undetectable
6dm2D-5tqrA:
undetectable		 6dm2A-5tqrA:
8.43
6dm2D-5tqrA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE

(Marinobacter
hydrocarbonoclasticus) 		PF00171
(Aldedh) 		5 ILE A  88
PRO A 152
SER A  24
LEU A  84
LEU A   4
 None
 1.46A 6dm2A-5u0lA:
undetectable
6dm2D-5u0lA:
undetectable		 6dm2A-5u0lA:
9.57
6dm2D-5u0lA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f DNA REPLICATION
LICENSING FACTOR
MCM7

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 PRO 7 580
SER 7 726
MET 7 600
SER 7 723
ASP 7 427
 None
 1.02A 6dm2A-5v8f7:
undetectable
6dm2D-5v8f7:
undetectable		 6dm2A-5v8f7:
6.52
6dm2D-5v8f7:
6.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		7 MET A 496
SER A 497
LEU A 751
SER A 754
LEU A 759
ASP A 760
LYS A 763
 None
 0.85A 6dm2A-5welA:
53.6
6dm2D-5welA:
53.2		 6dm2A-5welA:
100.00
6dm2D-5welA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		7 MET A 496
SER A 497
LEU A 751
SER A 754
LEU A 759
ASP A 760
LYS A 763
 CYZ  A1302 (-4.3A)
CYZ  A1302 (-3.2A)
None
CYZ  A1302 ( 4.1A)
None
CYZ  A1302 (-3.8A)
CYZ  A1302 (-2.9A)
 0.43A 6dm2A-5weoA:
56.2
6dm2D-5weoA:
56.1		 6dm2A-5weoA:
100.00
6dm2D-5weoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu7 UNCHARACTERIZED
PROTEIN

(Pyrococcus
horikoshii) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		5 ILE A 167
PRO A 178
SER A 143
SER A  59
LEU A 183
 None
 1.47A 6dm2A-5wu7A:
1.9
6dm2D-5wu7A:
2.7		 6dm2A-5wu7A:
10.17
6dm2D-5wu7A:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE SUBUNIT
BETA

(Trypanosoma
brucei) 		no annotation 5 ILE D 172
SER D 311
LEU D 160
LEU D 334
ASP D 335
 None
 1.26A 6dm2A-6f5dD:
4.3
6dm2D-6f5dD:
2.3		 6dm2A-6f5dD:
21.51
6dm2D-6f5dD:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g3w PROBABLE INACTIVE
RECEPTOR KINASE
AT1G27190

(Arabidopsis
thaliana) 		no annotation 5 ILE B 185
PRO B 207
SER B 175
LEU B 203
ASP B 154
 None
 1.49A 6dm2A-6g3wB:
undetectable
6dm2D-6g3wB:
undetectable		 6dm2A-6g3wB:
15.66
6dm2D-6g3wB:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gl3 -

(-) 		no annotation 5 ILE A 329
PRO A 370
SER A 607
LEU A 569
ASP A 568
 None
 1.41A 6dm2A-6gl3A:
undetectable
6dm2D-6gl3A:
undetectable		 6dm2A-6gl3A:
undetectable
6dm2D-6gl3A:
undetectable