SIMILAR PATTERNS OF AMINO ACIDS FOR 6DM1_D_CYZD1302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czf POLYGALACTURONASE II

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		5 PRO A  88
SER A 153
SER A  93
LEU A 134
ASP A 135
 None
 1.08A 6dm1A-1czfA:
undetectable
6dm1D-1czfA:
undetectable		 6dm1A-1czfA:
11.60
6dm1D-1czfA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgs DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		5 ILE A 153
PRO A 250
LEU A 123
SER A 121
LEU A 120
 None
None
None
None
AMP  A 700 ( 4.7A)
 1.21A 6dm1A-1dgsA:
3.0
6dm1D-1dgsA:
2.9		 6dm1A-1dgsA:
7.75
6dm1D-1dgsA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3l PROTEIN ARGININE
METHYLTRANSFERASE
PRMT3

(Rattus
norvegicus) 		PF06325
(PrmA) 		5 ILE A 454
PRO A 357
LEU A 332
LEU A 429
ASP A 428
 None
 1.39A 6dm1A-1f3lA:
undetectable
6dm1D-1f3lA:
undetectable		 6dm1A-1f3lA:
14.64
6dm1D-1f3lA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mor GLUCOSAMINE
6-PHOSPHATE SYNTHASE

(Escherichia
coli) 		PF01380
(SIS) 		5 ILE A 297
SER A 370
SER A 362
LEU A 346
LEU A 381
 None
 1.42A 6dm1A-1morA:
2.0
6dm1D-1morA:
5.1		 6dm1A-1morA:
13.47
6dm1D-1morA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1peg HISTONE H3
METHYLTRANSFERASE
DIM-5

(Neurospora
crassa) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 ILE A 183
SER A  49
SER A 234
LEU A 265
ASP A 264
 None
 1.32A 6dm1A-1pegA:
undetectable
6dm1D-1pegA:
undetectable		 6dm1A-1pegA:
13.67
6dm1D-1pegA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdm PROPHYTEPSIN

(Hordeum vulgare) 		PF00026
(Asp)
PF03489
(SapB_2)
PF05184
(SapB_1) 		5 ILE A  22
SER A  93
SER A  66
LEU A  42
ASP A 103
 None
 1.30A 6dm1A-1qdmA:
undetectable
6dm1D-1qdmA:
undetectable		 6dm1A-1qdmA:
10.35
6dm1D-1qdmA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqj OLIGOXYLOGLUCAN
REDUCING-END-SPECIFI
C CELLOBIOHYDROLASE

(Geotrichum sp.
M128) 		PF15899
(BNR_6) 		5 PRO A 742
PRO A 642
SER A 679
SER A 597
LEU A 596
 None
 1.26A 6dm1A-1sqjA:
undetectable
6dm1D-1sqjA:
undetectable		 6dm1A-1sqjA:
8.06
6dm1D-1sqjA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae) 		PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		5 ILE C 109
LEU C 128
LEU C 212
ASP C 215
LYS C 211
 None
 1.28A 6dm1A-1wa5C:
2.9
6dm1D-1wa5C:
3.4		 6dm1A-1wa5C:
6.01
6dm1D-1wa5C:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xq9 PHOSPHOGLYCERATE
MUTASE

(Plasmodium
falciparum) 		PF00300
(His_Phos_1) 		5 PRO A 130
LEU A 103
SER A 102
LEU A 134
ASP A 135
 None
 1.37A 6dm1A-1xq9A:
undetectable
6dm1D-1xq9A:
undetectable		 6dm1A-1xq9A:
13.62
6dm1D-1xq9A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yj5 5' POLYNUCLEOTIDE
KINASE-3'
PHOSPHATASE FHA
DOMAIN

(Mus musculus) 		no annotation 5 ILE C  54
PRO C  57
SER C  59
LEU C 104
ASP C  91
 None
 1.37A 6dm1A-1yj5C:
undetectable
6dm1D-1yj5C:
undetectable		 6dm1A-1yj5C:
17.36
6dm1D-1yj5C:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjm POLYNUCLEOTIDE
5'-HYDROXYL-KINASE

(Mus musculus) 		no annotation 5 ILE A  54
PRO A  57
SER A  59
LEU A 104
ASP A  91
 None
 1.40A 6dm1A-1yjmA:
undetectable
6dm1D-1yjmA:
undetectable		 6dm1A-1yjmA:
19.30
6dm1D-1yjmA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zt2 DNA PRIMASE LARGE
SUBUNIT

(Sulfolobus
solfataricus) 		PF04104
(DNA_primase_lrg) 		5 ILE B 199
PRO B 200
LEU B  72
LEU B  18
ASP B  15
 None
SO4  B 218 (-4.0A)
None
None
None
 1.29A 6dm1A-1zt2B:
undetectable
6dm1D-1zt2B:
2.2		 6dm1A-1zt2B:
15.08
6dm1D-1zt2B:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bku IMPORTIN BETA-1
SUBUNIT

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 ILE B 492
PRO B 491
PRO B 448
LEU B 480
LYS B 402
 None
 1.44A 6dm1A-2bkuB:
undetectable
6dm1D-2bkuB:
3.0		 6dm1A-2bkuB:
7.97
6dm1D-2bkuB:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cso PLECKSTRIN

(Homo sapiens) 		PF00610
(DEP) 		5 ILE A  32
SER A  62
LEU A  82
LEU A  18
ASP A  17
 None
 1.36A 6dm1A-2csoA:
undetectable
6dm1D-2csoA:
undetectable		 6dm1A-2csoA:
18.60
6dm1D-2csoA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF01368
(DHH)
PF02833
(DHHA2) 		5 ILE A  19
PRO A  51
SER A  14
LEU A 139
ASP A 147
 None
None
MN  A 501 ( 3.7A)
None
MN  A 502 (-2.6A)
 1.03A 6dm1A-2eb0A:
undetectable
6dm1D-2eb0A:
undetectable		 6dm1A-2eb0A:
12.96
6dm1D-2eb0A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum) 		PF00440
(TetR_N) 		5 ILE A 156
SER A 130
LEU A 160
LEU A  74
ASP A  71
 None
None
EDO  A 197 ( 4.8A)
EDO  A 197 ( 3.9A)
None
 1.21A 6dm1A-2hytA:
undetectable
6dm1D-2hytA:
2.0		 6dm1A-2hytA:
14.78
6dm1D-2hytA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum) 		PF00440
(TetR_N) 		5 ILE A 156
SER A 130
SER A  78
LEU A 160
ASP A  71
 None
None
None
EDO  A 197 ( 4.8A)
None
 1.16A 6dm1A-2hytA:
undetectable
6dm1D-2hytA:
2.0		 6dm1A-2hytA:
14.78
6dm1D-2hytA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuw ALKYLATED REPAIR
PROTEIN ALKB HOMOLOG
3

(Homo sapiens) 		PF13532
(2OG-FeII_Oxy_2) 		5 ILE A 237
PRO A  94
LEU A 239
SER A 206
LEU A 207
 None
None
None
AKG  A 700 ( 4.1A)
None
 1.42A 6dm1A-2iuwA:
undetectable
6dm1D-2iuwA:
undetectable		 6dm1A-2iuwA:
15.15
6dm1D-2iuwA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo sapiens) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		5 ILE A 563
SER A 558
PRO A 523
LEU A 544
LEU A 551
 None
 1.33A 6dm1A-2pkgA:
2.8
6dm1D-2pkgA:
undetectable		 6dm1A-2pkgA:
10.18
6dm1D-2pkgA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pt5 SHIKIMATE KINASE

(Aquifex
aeolicus) 		PF01202
(SKI) 		5 ILE A   3
SER A  18
PRO A  27
LEU A  24
SER A  23
 None
 1.42A 6dm1A-2pt5A:
2.0
6dm1D-2pt5A:
2.1		 6dm1A-2pt5A:
19.14
6dm1D-2pt5A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 3

(Sulfolobus
solfataricus) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		5 ILE B 147
SER B  57
SER B 197
LEU B 149
LEU B  59
 None
 1.34A 6dm1A-2qbyB:
2.7
6dm1D-2qbyB:
2.1		 6dm1A-2qbyB:
11.83
6dm1D-2qbyB:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quy PENICILLIN ACYLASE

(Lysinibacillus
sphaericus) 		PF02275
(CBAH) 		5 ILE A  30
SER A  64
PRO A  33
LEU A  67
SER A 107
 None
 1.36A 6dm1A-2quyA:
undetectable
6dm1D-2quyA:
undetectable		 6dm1A-2quyA:
16.61
6dm1D-2quyA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xde GAG POLYPROTEIN

(Human
immunodeficiency
virus 1) 		PF00607
(Gag_p24) 		5 ILE A 124
PRO A  99
SER A 109
LEU A  52
ASP A  51
 None
 1.41A 6dm1A-2xdeA:
undetectable
6dm1D-2xdeA:
undetectable		 6dm1A-2xdeA:
19.42
6dm1D-2xdeA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN

(Aquifex
aeolicus) 		PF01867
(Cas_Cas1) 		5 SER A 203
SER A 209
LEU A 190
SER A 216
LEU A 217
 None
 1.27A 6dm1A-2yzsA:
undetectable
6dm1D-2yzsA:
undetectable		 6dm1A-2yzsA:
12.70
6dm1D-2yzsA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		5 PRO A 517
MET A 519
LEU A 768
LEU A 776
LYS A 780
 None
 0.84A 6dm1A-2znsA:
32.3
6dm1D-2znsA:
31.6		 6dm1A-2znsA:
14.51
6dm1D-2znsA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Thermotoga
maritima;
Thermotoga
maritima) 		PF01425
(Amidase)
PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		5 PRO A 300
SER A 304
LEU A 197
SER A 196
ASP B 281
 None
 1.42A 6dm1A-3al0A:
undetectable
6dm1D-3al0A:
2.2		 6dm1A-3al0A:
10.87
6dm1D-3al0A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqk POLY(A) POLYMERASE

(Escherichia
coli) 		PF01743
(PolyA_pol)
PF12626
(PolyA_pol_arg_C)
PF12627
(PolyA_pol_RNAbd) 		5 ILE A 220
PRO A 219
SER A 213
PRO A 187
ASP A 175
 None
 1.17A 6dm1A-3aqkA:
undetectable
6dm1D-3aqkA:
undetectable		 6dm1A-3aqkA:
9.68
6dm1D-3aqkA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT
MEMBRANE-BOUND
HYDROGENASE SMALL
SUBUNIT

(Hydrogenovibrio
marinus;
Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 ILE A 171
PRO A 134
MET B  55
LEU B  43
ASP B  49
 None
 1.13A 6dm1A-3ayxA:
undetectable
6dm1D-3ayxA:
2.8		 6dm1A-3ayxA:
8.84
6dm1D-3ayxA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5w PP2A A SUBUNIT

(Homo sapiens) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		5 ILE A 563
SER A 558
PRO A 523
LEU A 544
LEU A 551
 None
 1.37A 6dm1A-3c5wA:
undetectable
6dm1D-3c5wA:
undetectable		 6dm1A-3c5wA:
17.39
6dm1D-3c5wA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc1 PUTATIVE
ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bacillus
halodurans) 		PF16499
(Melibiase_2) 		5 ILE A 416
SER A 413
LEU A 426
LEU A 385
ASP A 386
 None
 1.23A 6dm1A-3cc1A:
undetectable
6dm1D-3cc1A:
undetectable		 6dm1A-3cc1A:
10.50
6dm1D-3cc1A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg1 UPF0100 PROTEIN
PF0080

(Pyrococcus
furiosus) 		PF13531
(SBP_bac_11) 		5 ILE A 279
PRO A 161
LEU A 272
SER A 274
ASP A  84
 None
WO4  A 701 (-3.7A)
None
None
None
 1.42A 6dm1A-3cg1A:
2.1
6dm1D-3cg1A:
9.7		 6dm1A-3cg1A:
14.53
6dm1D-3cg1A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftj MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcomitans) 		PF12704
(MacB_PCD) 		5 ILE A 472
PRO A 439
LEU A 379
SER A 463
ASP A 404
 None
 1.45A 6dm1A-3ftjA:
undetectable
6dm1D-3ftjA:
undetectable		 6dm1A-3ftjA:
18.91
6dm1D-3ftjA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7q VALINE-PYRUVATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00155
(Aminotran_1_2) 		5 PRO A 281
SER A 246
PRO A 286
SER A 255
LEU A  83
 None
 1.40A 6dm1A-3g7qA:
2.4
6dm1D-3g7qA:
3.0		 6dm1A-3g7qA:
10.55
6dm1D-3g7qA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8l NADH OXIDASE

(Acidianus
ambivalens) 		PF07992
(Pyr_redox_2) 		5 ILE A 288
MET A  87
SER A  86
LEU A 274
SER A 277
 None
 1.13A 6dm1A-3h8lA:
4.2
6dm1D-3h8lA:
undetectable		 6dm1A-3h8lA:
11.93
6dm1D-3h8lA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hul HOMOSERINE KINASE

(Listeria
monocytogenes) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 ILE A 159
PRO A 160
SER A 219
LEU A  84
SER A 243
 None
 1.41A 6dm1A-3hulA:
undetectable
6dm1D-3hulA:
undetectable		 6dm1A-3hulA:
13.45
6dm1D-3hulA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		5 ILE A  73
LEU A  48
SER A  52
LEU A 114
LYS A 118
 None
 1.44A 6dm1A-3hveA:
undetectable
6dm1D-3hveA:
undetectable		 6dm1A-3hveA:
12.80
6dm1D-3hveA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwp PHLG

(Pseudomonas
protegens) 		no annotation 5 SER A 227
MET A 212
SER A 196
LEU A  61
ASP A 271
 None
 1.30A 6dm1A-3hwpA:
undetectable
6dm1D-3hwpA:
undetectable		 6dm1A-3hwpA:
15.47
6dm1D-3hwpA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8o KH DOMAIN-CONTAINING
PROTEIN MJ1533

(Methanocaldococcus
jannaschii) 		PF01850
(PIN) 		5 ILE A  57
PRO A  58
SER A 130
LEU A  86
LEU A  50
 None
 1.43A 6dm1A-3i8oA:
2.4
6dm1D-3i8oA:
2.6		 6dm1A-3i8oA:
20.14
6dm1D-3i8oA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4u MAJOR CAPSID PROTEIN

(Bordetella
virus BPP1) 		no annotation 5 ILE A 315
PRO A 316
MET A  42
LEU A 175
LEU A 183
 None
 1.45A 6dm1A-3j4uA:
undetectable
6dm1D-3j4uA:
undetectable		 6dm1A-3j4uA:
12.65
6dm1D-3j4uA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jro FUSION PROTEIN OF
PROTEIN TRANSPORT
PROTEIN SEC13 AND
NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12110
(Nup96) 		5 ILE A1533
PRO A1209
LEU A1492
LEU A1191
ASP A1192
 None
 1.44A 6dm1A-3jroA:
2.2
6dm1D-3jroA:
undetectable		 6dm1A-3jroA:
9.28
6dm1D-3jroA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kpt COLLAGEN ADHESION
PROTEIN

(Bacillus cereus) 		no annotation 5 ILE A 381
PRO A 408
PRO A 286
LEU A 318
SER A 369
 None
 1.31A 6dm1A-3kptA:
undetectable
6dm1D-3kptA:
undetectable		 6dm1A-3kptA:
12.15
6dm1D-3kptA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nks PROTOPORPHYRINOGEN
OXIDASE

(Homo sapiens) 		PF01593
(Amino_oxidase) 		5 ILE A 460
PRO A 237
MET A 235
LEU A  74
LEU A  80
 None
 1.32A 6dm1A-3nksA:
3.0
6dm1D-3nksA:
undetectable		 6dm1A-3nksA:
8.39
6dm1D-3nksA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzu PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		5 ILE A 739
PRO A 786
SER A 701
LEU A 838
ASP A 837
 None
 1.36A 6dm1A-3nzuA:
undetectable
6dm1D-3nzuA:
undetectable		 6dm1A-3nzuA:
7.54
6dm1D-3nzuA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ol2 SEMAPHORIN-4D

(Homo sapiens) 		PF00047
(ig)
PF01403
(Sema)
PF01437
(PSI) 		5 ILE A 460
SER A 442
LEU A 413
LEU A 312
ASP A 295
 None
 1.35A 6dm1A-3ol2A:
undetectable
6dm1D-3ol2A:
undetectable		 6dm1A-3ol2A:
8.63
6dm1D-3ol2A:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q63 MLL2253 PROTEIN

(Mesorhizobium
japonicum) 		PF08327
(AHSA1) 		5 SER A  18
PRO A  21
LEU A 106
LEU A 139
ASP A 140
 None
 1.36A 6dm1A-3q63A:
undetectable
6dm1D-3q63A:
undetectable		 6dm1A-3q63A:
18.06
6dm1D-3q63A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qe7 URACIL PERMEASE

(Escherichia
coli) 		PF00860
(Xan_ur_permease) 		5 ILE A 329
PRO A 330
PRO A 332
SER A 338
LEU A 339
 None
 1.37A 6dm1A-3qe7A:
undetectable
6dm1D-3qe7A:
2.8		 6dm1A-3qe7A:
11.06
6dm1D-3qe7A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		5 PRO A 501
MET A 503
LEU A 752
LEU A 760
LYS A 764
 None
 0.84A 6dm1A-3qxmA:
32.5
6dm1D-3qxmA:
31.9		 6dm1A-3qxmA:
16.86
6dm1D-3qxmA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7b ACETYLGLUTAMATE
KINASE

(Yersinia pestis) 		PF00696
(AA_kinase) 		5 PRO A 243
LEU A 178
LEU A   4
ASP A 174
LYS A   0
 None
 1.45A 6dm1A-3t7bA:
undetectable
6dm1D-3t7bA:
undetectable		 6dm1A-3t7bA:
14.86
6dm1D-3t7bA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0j TYPE III EFFECTOR
HOPU1

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 PRO B 239
MET B 241
SER B 242
LEU B 145
LEU B 118
 None
 0.95A 6dm1A-3u0jB:
undetectable
6dm1D-3u0jB:
undetectable		 6dm1A-3u0jB:
14.83
6dm1D-3u0jB:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 ILE A 462
PRO A 463
SER A 504
PRO A 501
LEU A 495
 None
 1.37A 6dm1A-3u1kA:
undetectable
6dm1D-3u1kA:
undetectable		 6dm1A-3u1kA:
9.06
6dm1D-3u1kA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u8p CYTOCHROME B562
INTEGRAL FUSION WITH
ENHANCED GREEN
FLUORESCENT PROTEIN

(Escherichia
coli;
Aequorea
victoria) 		PF01353
(GFP)
PF07361
(Cytochrom_B562) 		5 ILE A 260
PRO A 304
SER A 194
LEU A 309
SER A 180
 None
 1.44A 6dm1A-3u8pA:
6.0
6dm1D-3u8pA:
3.7		 6dm1A-3u8pA:
13.66
6dm1D-3u8pA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
halstedii) 		PF00501
(AMP-binding) 		5 ILE A 334
PRO A 336
LEU A 351
SER A 208
LEU A  25
 None
 1.45A 6dm1A-3wv4A:
3.7
6dm1D-3wv4A:
4.9		 6dm1A-3wv4A:
15.05
6dm1D-3wv4A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvi TYPE-2 RESTRICTION
ENZYME HINDIII

(Haemophilus
influenzae) 		PF09518
(RE_HindIII) 		5 PRO A 149
LEU A 166
SER A 159
LEU A 160
ASP A 161
 None
 1.41A 6dm1A-3wviA:
undetectable
6dm1D-3wviA:
undetectable		 6dm1A-3wviA:
15.85
6dm1D-3wviA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4u BIFUNCTIONAL PROTEIN
FOLD

(Acinetobacter
baumannii) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 ILE A 104
PRO A 101
SER A  46
LEU A  78
ASP A 120
 None
 1.37A 6dm1A-4b4uA:
4.6
6dm1D-4b4uA:
4.6		 6dm1A-4b4uA:
12.87
6dm1D-4b4uA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxs VENOM PROTHROMBIN
ACTIVATOR
PSEUTARIN-C
NON-CATALYTIC
SUBUNIT

(Pseudonaja
textilis) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		5 ILE V 299
SER V 272
LEU V 297
LEU V 249
ASP V 270
 None
 1.42A 6dm1A-4bxsV:
undetectable
6dm1D-4bxsV:
undetectable		 6dm1A-4bxsV:
4.95
6dm1D-4bxsV:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF05292
(MCD)
PF17408
(MCD_N) 		5 ILE A 331
PRO A 332
PRO A 418
LEU A 406
LEU A 424
 None
 1.38A 6dm1A-4f0xA:
undetectable
6dm1D-4f0xA:
undetectable		 6dm1A-4f0xA:
10.24
6dm1D-4f0xA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcg UNCHARACTERIZED
PROTEIN

(Xanthomonas
euvesicatoria) 		PF13855
(LRR_8) 		5 ILE A 268
PRO A 289
SER A 323
LEU A 277
LEU A 330
 None
None
CL  A 503 (-2.9A)
None
None
 0.81A 6dm1A-4fcgA:
undetectable
6dm1D-4fcgA:
undetectable		 6dm1A-4fcgA:
15.54
6dm1D-4fcgA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcg UNCHARACTERIZED
PROTEIN

(Xanthomonas
euvesicatoria) 		PF13855
(LRR_8) 		5 ILE A 395
PRO A 392
LEU A 398
LEU A 356
ASP A 357
 None
 1.45A 6dm1A-4fcgA:
undetectable
6dm1D-4fcgA:
undetectable		 6dm1A-4fcgA:
15.54
6dm1D-4fcgA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq2 NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		5 SER M 283
LEU M 252
SER M 239
LEU M 174
ASP M 113
 None
 1.26A 6dm1A-4gq2M:
5.6
6dm1D-4gq2M:
2.6		 6dm1A-4gq2M:
6.47
6dm1D-4gq2M:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1

(Bothrops
jararacussu) 		PF00089
(Trypsin) 		5 ILE A  89
PRO A  67
SER A  43
SER A  20
LEU A  27
 None
 1.30A 6dm1A-4gsoA:
undetectable
6dm1D-4gsoA:
undetectable		 6dm1A-4gsoA:
13.19
6dm1D-4gsoA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		5 PRO A  67
SER A  58
SER A  75
LEU A 343
LEU A  43
 None
 1.35A 6dm1A-4iglA:
undetectable
6dm1D-4iglA:
undetectable		 6dm1A-4iglA:
4.21
6dm1D-4iglA:
4.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0m SERINE/THREONINE-PRO
TEIN KINASE
BRI1-LIKE 1

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 ILE A 675
SER A 647
LEU A 563
LEU A 554
ASP A 553
 None
 1.29A 6dm1A-4j0mA:
undetectable
6dm1D-4j0mA:
undetectable		 6dm1A-4j0mA:
7.66
6dm1D-4j0mA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 ILE A 567
PRO A 592
SER A 597
LEU A 582
LEU A 577
 None
 1.43A 6dm1A-4mn8A:
undetectable
6dm1D-4mn8A:
undetectable		 6dm1A-4mn8A:
6.72
6dm1D-4mn8A:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 ILE A 567
PRO A 592
SER A 597
LEU A 582
LEU A 577
 None
 1.36A 6dm1A-4mnaA:
undetectable
6dm1D-4mnaA:
undetectable		 6dm1A-4mnaA:
7.51
6dm1D-4mnaA:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzh LIC12234

(Leptospira
interrogans) 		PF13855
(LRR_8) 		5 ILE A  84
PRO A  81
LEU A  87
LEU A  47
ASP A  48
 None
None
None
None
CL  A 306 ( 4.1A)
 1.34A 6dm1A-4tzhA:
undetectable
6dm1D-4tzhA:
undetectable		 6dm1A-4tzhA:
18.02
6dm1D-4tzhA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u09 LIC12759

(Leptospira
interrogans) 		PF13855
(LRR_8) 		5 ILE A 221
PRO A 218
LEU A 224
LEU A 184
ASP A 185
 None
 1.40A 6dm1A-4u09A:
undetectable
6dm1D-4u09A:
undetectable		 6dm1A-4u09A:
8.64
6dm1D-4u09A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB

(Drosophila
melanogaster) 		PF10613
(Lig_chan-Glu_bd) 		5 PRO A 112
MET A 114
LEU A 245
SER A 248
LEU A 253
 None
 0.92A 6dm1A-4wxjA:
32.2
6dm1D-4wxjA:
31.5		 6dm1A-4wxjA:
14.02
6dm1D-4wxjA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 ILE A 240
PRO A 261
SER A 287
LEU A 249
LEU A 294
 None
 1.26A 6dm1A-4z64A:
undetectable
6dm1D-4z64A:
undetectable		 6dm1A-4z64A:
8.88
6dm1D-4z64A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 ILE A 379
PRO A 407
LEU A 397
LEU A 392
LYS A 390
 None
 1.29A 6dm1A-4z64A:
undetectable
6dm1D-4z64A:
undetectable		 6dm1A-4z64A:
8.88
6dm1D-4z64A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zf4 GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		5 ILE A 102
PRO A 146
SER A  36
LEU A 151
SER A  22
 None
 1.45A 6dm1A-4zf4A:
undetectable
6dm1D-4zf4A:
undetectable		 6dm1A-4zf4A:
16.27
6dm1D-4zf4A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwn MONOGLYCERIDE LIPASE

(Saccharomyces
cerevisiae) 		PF12146
(Hydrolase_4) 		5 ILE A  55
SER A 123
LEU A 286
SER A 282
ASP A 251
 None
 1.32A 6dm1A-4zwnA:
undetectable
6dm1D-4zwnA:
3.2		 6dm1A-4zwnA:
12.58
6dm1D-4zwnA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxk SIALIDASE A

(Streptococcus
pneumoniae) 		PF02973
(Sialidase) 		5 ILE A 269
SER A 140
SER A 174
LEU A 289
LEU A 146
 None
 1.32A 6dm1A-4zxkA:
undetectable
6dm1D-4zxkA:
undetectable		 6dm1A-4zxkA:
15.03
6dm1D-4zxkA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
BETA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		PF02239
(Cytochrom_D1) 		5 ILE B 157
PRO B 178
SER B 174
SER B 203
LEU B 190
 None
 1.41A 6dm1A-5c2vB:
undetectable
6dm1D-5c2vB:
undetectable		 6dm1A-5c2vB:
12.50
6dm1D-5c2vB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5da0 SULPHATE TRANSPORTER

(Deinococcus
geothermalis) 		PF00916
(Sulfate_transp)
PF01740
(STAS) 		5 PRO A 229
SER A 373
LEU A 107
SER A 235
LEU A 236
 None
None
None
None
DMU  A 601 ( 4.0A)
 1.29A 6dm1A-5da0A:
undetectable
6dm1D-5da0A:
undetectable		 6dm1A-5da0A:
11.56
6dm1D-5da0A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtb CG3822

(Drosophila
melanogaster) 		PF10613
(Lig_chan-Glu_bd) 		5 PRO A 109
MET A 111
LEU A 242
LEU A 250
LYS A 254
 None
 0.62A 6dm1A-5dtbA:
33.3
6dm1D-5dtbA:
32.8		 6dm1A-5dtbA:
14.77
6dm1D-5dtbA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 ILE D 198
SER D 337
LEU D 186
LEU D 360
ASP D 361
 None
 1.24A 6dm1A-5fl7D:
4.2
6dm1D-5fl7D:
4.0		 6dm1A-5fl7D:
9.77
6dm1D-5fl7D:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fo9 COMPLEMENT RECEPTOR
TYPE 1

(Homo sapiens) 		PF00084
(Sushi) 		5 ILE C1072
PRO C1070
SER C1112
PRO C1128
SER C1126
 None
 1.30A 6dm1A-5fo9C:
undetectable
6dm1D-5fo9C:
undetectable		 6dm1A-5fo9C:
19.27
6dm1D-5fo9C:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fya PATATIN-LIKE
PROTEIN, PLPD

(Pseudomonas
aeruginosa) 		PF01734
(Patatin) 		5 PRO A 182
SER A 149
LEU A  68
SER A  71
LEU A 157
 None
 1.22A 6dm1A-5fyaA:
2.7
6dm1D-5fyaA:
2.6		 6dm1A-5fyaA:
13.50
6dm1D-5fyaA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		5 ILE A  29
SER A  95
SER A  43
LEU A   9
SER A 108
 None
 1.33A 6dm1A-5hp5A:
undetectable
6dm1D-5hp5A:
undetectable		 6dm1A-5hp5A:
8.24
6dm1D-5hp5A:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz1 PROBABLE LRR
RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
AT4G26540

(Arabidopsis
thaliana) 		PF13855
(LRR_8) 		5 ILE B 278
PRO B 279
SER B 275
LEU B 293
LEU B 250
 None
 1.30A 6dm1A-5hz1B:
undetectable
6dm1D-5hz1B:
undetectable		 6dm1A-5hz1B:
11.87
6dm1D-5hz1B:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iof SULPHATE TRANSPORTER

(Deinococcus
geothermalis) 		PF00916
(Sulfate_transp) 		5 PRO A 229
SER A 373
LEU A 107
SER A 235
LEU A 236
 None
 1.29A 6dm1A-5iofA:
undetectable
6dm1D-5iofA:
undetectable		 6dm1A-5iofA:
14.67
6dm1D-5iofA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
PF01194
(RNA_pol_N) 		5 ILE C  46
SER C 237
LEU C 118
SER C 115
ASP J  16
 None
 1.39A 6dm1A-5ip7C:
undetectable
6dm1D-5ip7C:
undetectable		 6dm1A-5ip7C:
14.29
6dm1D-5ip7C:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 ILE A 447
PRO A 468
SER A 494
LEU A 456
LEU A 501
 None
 1.25A 6dm1A-5ixqA:
undetectable
6dm1D-5ixqA:
undetectable		 6dm1A-5ixqA:
8.44
6dm1D-5ixqA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuf GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 PRO A 501
MET A 503
LEU A 752
LEU A 760
LYS A 764
 None
 0.69A 6dm1A-5kufA:
38.3
6dm1D-5kufA:
37.8		 6dm1A-5kufA:
6.53
6dm1D-5kufA:
6.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 MET A 496
LEU A 751
LEU A 759
ASP A 760
LYS A 763
 None
 0.79A 6dm1A-5l1bA:
40.4
6dm1D-5l1bA:
40.1		 6dm1A-5l1bA:
100.00
6dm1D-5l1bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 MET A 496
LEU A 751
SER A 754
LEU A 759
LYS A 763
 None
 0.96A 6dm1A-5l1bA:
40.4
6dm1D-5l1bA:
40.1		 6dm1A-5l1bA:
100.00
6dm1D-5l1bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 MET A 496
SER A 497
LEU A 751
LEU A 759
LYS A 763
 None
 0.80A 6dm1A-5l1bA:
40.4
6dm1D-5l1bA:
40.1		 6dm1A-5l1bA:
100.00
6dm1D-5l1bA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
3, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL

(Bos taurus;
Bos taurus) 		PF00329
(Complex1_30kDa)
PF00346
(Complex1_49kDa) 		5 ILE D 265
SER D 256
LEU D 251
SER C  74
ASP C  77
 None
 1.41A 6dm1A-5lc5D:
2.2
6dm1D-5lc5D:
2.9		 6dm1A-5lc5D:
9.95
6dm1D-5lc5D:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2n ELONGATOR COMPLEX
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 ILE A 755
PRO A 751
LEU A 758
SER A 721
LEU A 731
 None
 1.33A 6dm1A-5m2nA:
undetectable
6dm1D-5m2nA:
undetectable		 6dm1A-5m2nA:
9.00
6dm1D-5m2nA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mbg BETA SUBUNIT OF
PHOTOACTIVATED
ADENYLYL CYCLASE

(Beggiatoa sp.
PS) 		PF00211
(Guanylate_cyc) 		5 ILE A 152
LEU A 248
SER A 219
LEU A 220
ASP A 221
 None
 1.27A 6dm1A-5mbgA:
undetectable
6dm1D-5mbgA:
undetectable		 6dm1A-5mbgA:
17.82
6dm1D-5mbgA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1t FLAVIN-BINDING
SUBUNIT OF SULFIDE
DEHYDROGENASE

(Thioalkalivibrio
paradoxus) 		no annotation 5 ILE A 219
PRO A 186
PRO A 197
SER A 202
LEU A 203
 None
 1.44A 6dm1A-5n1tA:
3.2
6dm1D-5n1tA:
3.0		 6dm1A-5n1tA:
21.43
6dm1D-5n1tA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nhs BIFUNCTIONAL PROTEIN
FOLD

(Xanthomonas
albilineans) 		no annotation 5 ILE A 113
PRO A 111
SER A  56
LEU A 119
ASP A 130
 None
 1.38A 6dm1A-5nhsA:
4.1
6dm1D-5nhsA:
2.8		 6dm1A-5nhsA:
19.51
6dm1D-5nhsA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ns8 -

(-) 		no annotation 5 ILE A 261
SER A 192
LEU A 305
LEU A 174
ASP A 184
 None
None
GOL  A 504 (-3.6A)
None
None
 1.31A 6dm1A-5ns8A:
undetectable
6dm1D-5ns8A:
undetectable		 6dm1A-5ns8A:
undetectable
6dm1D-5ns8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjf ALLOPHYCOCYANIN
ALPHA SUBUNIT
ALLOPHYCOCYANIN BETA
SUBUNIT

(Gracilaria
chilensis;
Gracilaria
chilensis) 		PF00502
(Phycobilisome)
PF00502
(Phycobilisome) 		5 ILE B   9
PRO A 103
LEU B  19
LEU A  89
ASP A  86
 None
 1.38A 6dm1A-5tjfB:
undetectable
6dm1D-5tjfB:
2.1		 6dm1A-5tjfB:
19.15
6dm1D-5tjfB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqr POLYCOMB PROTEIN EED

(Chaetomium
thermophilum) 		PF00400
(WD40) 		5 PRO A  47
LEU A 111
SER A  98
LEU A 144
ASP A 143
 None
 1.29A 6dm1A-5tqrA:
undetectable
6dm1D-5tqrA:
undetectable		 6dm1A-5tqrA:
8.43
6dm1D-5tqrA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f DNA REPLICATION
LICENSING FACTOR
MCM7

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 PRO 7 580
SER 7 726
MET 7 600
SER 7 723
ASP 7 427
 None
 1.02A 6dm1A-5v8f7:
2.3
6dm1D-5v8f7:
undetectable		 6dm1A-5v8f7:
6.52
6dm1D-5v8f7:
6.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		8 PRO A 494
MET A 496
SER A 497
LEU A 751
SER A 754
LEU A 759
ASP A 760
LYS A 763
 None
 0.81A 6dm1A-5welA:
53.6
6dm1D-5welA:
53.1		 6dm1A-5welA:
100.00
6dm1D-5welA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		8 PRO A 494
MET A 496
SER A 497
LEU A 751
SER A 754
LEU A 759
ASP A 760
LYS A 763
 CYZ  A1302 (-4.5A)
CYZ  A1302 (-4.3A)
CYZ  A1302 (-3.2A)
None
CYZ  A1302 ( 4.1A)
None
CYZ  A1302 (-3.8A)
CYZ  A1302 (-2.9A)
 0.43A 6dm1A-5weoA:
56.1
6dm1D-5weoA:
55.9		 6dm1A-5weoA:
100.00
6dm1D-5weoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g3u -

(-) 		no annotation 5 PRO A 344
PRO A  92
LEU A 131
LEU A  45
ASP A  13
 None
 1.42A 6dm1A-6g3uA:
undetectable
6dm1D-6g3uA:
2.1		 6dm1A-6g3uA:
undetectable
6dm1D-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gl3 -

(-) 		no annotation 5 ILE A 329
PRO A 370
SER A 607
LEU A 569
ASP A 568
 None
 1.40A 6dm1A-6gl3A:
undetectable
6dm1D-6gl3A:
undetectable		 6dm1A-6gl3A:
undetectable
6dm1D-6gl3A:
undetectable