SIMILAR PATTERNS OF AMINO ACIDS FOR 6DM1_B_CYZB1302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czf POLYGALACTURONASE II

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		5 SER A 153
SER A  93
LEU A 134
ASP A 135
PRO A  88
 None
 1.09A 6dm1B-1czfA:
undetectable
6dm1C-1czfA:
undetectable		 6dm1B-1czfA:
11.60
6dm1C-1czfA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgs DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		5 LEU A 123
SER A 121
LEU A 120
ILE A 153
PRO A 250
 None
None
AMP  A 700 ( 4.7A)
None
None
 1.20A 6dm1B-1dgsA:
4.7
6dm1C-1dgsA:
3.0		 6dm1B-1dgsA:
7.75
6dm1C-1dgsA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj2 ADENYLOSUCCINATE
SYNTHETASE

(Arabidopsis
thaliana) 		PF00709
(Adenylsucc_synt) 		5 LEU A 125
LEU A 183
ASP A 186
ILE A 152
SER A 157
 None
 1.48A 6dm1B-1dj2A:
undetectable
6dm1C-1dj2A:
undetectable		 6dm1B-1dj2A:
14.29
6dm1C-1dj2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3l PROTEIN ARGININE
METHYLTRANSFERASE
PRMT3

(Rattus
norvegicus) 		PF06325
(PrmA) 		5 LEU A 332
LEU A 429
ASP A 428
ILE A 454
PRO A 357
 None
 1.40A 6dm1B-1f3lA:
undetectable
6dm1C-1f3lA:
undetectable		 6dm1B-1f3lA:
14.64
6dm1C-1f3lA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Leishmania
mexicana) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		5 MET A 185
SER A 186
LEU A 258
SER A 169
LEU A 151
 None
 1.48A 6dm1B-1m66A:
2.5
6dm1C-1m66A:
3.2		 6dm1B-1m66A:
12.53
6dm1C-1m66A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mor GLUCOSAMINE
6-PHOSPHATE SYNTHASE

(Escherichia
coli) 		PF01380
(SIS) 		5 SER A 362
LEU A 346
LEU A 381
ILE A 297
SER A 370
 None
 1.42A 6dm1B-1morA:
4.7
6dm1C-1morA:
2.0		 6dm1B-1morA:
13.47
6dm1C-1morA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1peg HISTONE H3
METHYLTRANSFERASE
DIM-5

(Neurospora
crassa) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 SER A 234
LEU A 265
ASP A 264
ILE A 183
SER A  49
 None
 1.33A 6dm1B-1pegA:
undetectable
6dm1C-1pegA:
undetectable		 6dm1B-1pegA:
13.67
6dm1C-1pegA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdm PROPHYTEPSIN

(Hordeum vulgare) 		PF00026
(Asp)
PF03489
(SapB_2)
PF05184
(SapB_1) 		5 SER A  66
LEU A  42
ASP A 103
ILE A  22
SER A  93
 None
 1.30A 6dm1B-1qdmA:
undetectable
6dm1C-1qdmA:
undetectable		 6dm1B-1qdmA:
10.35
6dm1C-1qdmA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae) 		PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		5 LEU C 128
LEU C 212
ASP C 215
LYS C 211
ILE C 109
 None
 1.29A 6dm1B-1wa5C:
3.3
6dm1C-1wa5C:
2.9		 6dm1B-1wa5C:
6.01
6dm1C-1wa5C:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xq9 PHOSPHOGLYCERATE
MUTASE

(Plasmodium
falciparum) 		PF00300
(His_Phos_1) 		5 LEU A 103
SER A 102
LEU A 134
ASP A 135
PRO A 130
 None
 1.38A 6dm1B-1xq9A:
2.9
6dm1C-1xq9A:
undetectable		 6dm1B-1xq9A:
13.62
6dm1C-1xq9A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zt2 DNA PRIMASE LARGE
SUBUNIT

(Sulfolobus
solfataricus) 		PF04104
(DNA_primase_lrg) 		5 LEU B  72
LEU B  18
ASP B  15
ILE B 199
PRO B 200
 None
None
None
None
SO4  B 218 (-4.0A)
 1.29A 6dm1B-1zt2B:
2.2
6dm1C-1zt2B:
undetectable		 6dm1B-1zt2B:
15.08
6dm1C-1zt2B:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3q GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		5 SER A  86
LEU A 201
SER A  72
ILE A 152
PRO A 196
 None
 1.47A 6dm1B-2b3qA:
undetectable
6dm1C-2b3qA:
undetectable		 6dm1B-2b3qA:
14.81
6dm1C-2b3qA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cso PLECKSTRIN

(Homo sapiens) 		PF00610
(DEP) 		5 SER A  62
LEU A  82
LEU A  18
ASP A  17
ILE A  32
 None
 1.37A 6dm1B-2csoA:
undetectable
6dm1C-2csoA:
undetectable		 6dm1B-2csoA:
18.60
6dm1C-2csoA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF01368
(DHH)
PF02833
(DHHA2) 		5 LEU A 139
ASP A 147
ILE A  19
PRO A  51
SER A  14
 None
MN  A 502 (-2.6A)
None
None
MN  A 501 ( 3.7A)
 1.02A 6dm1B-2eb0A:
undetectable
6dm1C-2eb0A:
undetectable		 6dm1B-2eb0A:
12.96
6dm1C-2eb0A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE

(Bacillus sp.
NG-27) 		PF00331
(Glyco_hydro_10) 		5 SER A 244
LEU A 294
LEU A 301
ILE A 231
PRO A 236
 None
 1.50A 6dm1B-2f8qA:
undetectable
6dm1C-2f8qA:
undetectable		 6dm1B-2f8qA:
11.11
6dm1C-2f8qA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g16 GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		5 SER B  86
LEU B 201
SER B  72
ILE B 152
PRO B 196
 None
 1.50A 6dm1B-2g16B:
undetectable
6dm1C-2g16B:
undetectable		 6dm1B-2g16B:
18.45
6dm1C-2g16B:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum) 		PF00440
(TetR_N) 		5 LEU A 160
LEU A  74
ASP A  71
ILE A 156
SER A 130
 EDO  A 197 ( 4.8A)
EDO  A 197 ( 3.9A)
None
None
None
 1.22A 6dm1B-2hytA:
undetectable
6dm1C-2hytA:
undetectable		 6dm1B-2hytA:
14.78
6dm1C-2hytA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum) 		PF00440
(TetR_N) 		5 SER A  78
LEU A 160
ASP A  71
ILE A 156
SER A 130
 None
EDO  A 197 ( 4.8A)
None
None
None
 1.17A 6dm1B-2hytA:
undetectable
6dm1C-2hytA:
undetectable		 6dm1B-2hytA:
14.78
6dm1C-2hytA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 3

(Sulfolobus
solfataricus) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		5 SER B 197
LEU B 149
LEU B  59
ILE B 147
SER B  57
 None
 1.33A 6dm1B-2qbyB:
2.2
6dm1C-2qbyB:
2.4		 6dm1B-2qbyB:
11.83
6dm1C-2qbyB:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xde GAG POLYPROTEIN

(Human
immunodeficiency
virus 1) 		PF00607
(Gag_p24) 		5 SER A 109
LEU A  52
ASP A  51
ILE A 124
PRO A  99
 None
 1.42A 6dm1B-2xdeA:
undetectable
6dm1C-2xdeA:
undetectable		 6dm1B-2xdeA:
19.42
6dm1C-2xdeA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN

(Aquifex
aeolicus) 		PF01867
(Cas_Cas1) 		5 SER A 209
LEU A 190
SER A 216
LEU A 217
SER A 203
 None
 1.28A 6dm1B-2yzsA:
undetectable
6dm1C-2yzsA:
undetectable		 6dm1B-2yzsA:
12.70
6dm1C-2yzsA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT
MEMBRANE-BOUND
HYDROGENASE SMALL
SUBUNIT

(Hydrogenovibrio
marinus;
Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 MET B  55
LEU B  43
ASP B  49
ILE A 171
PRO A 134
 None
 1.13A 6dm1B-3ayxB:
3.9
6dm1C-3ayxB:
4.3		 6dm1B-3ayxB:
13.78
6dm1C-3ayxB:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc1 PUTATIVE
ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bacillus
halodurans) 		PF16499
(Melibiase_2) 		5 LEU A 426
LEU A 385
ASP A 386
ILE A 416
SER A 413
 None
 1.23A 6dm1B-3cc1A:
undetectable
6dm1C-3cc1A:
undetectable		 6dm1B-3cc1A:
10.50
6dm1C-3cc1A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evp GREEN FLUORESCENT
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		5 SER A 244
LEU A 114
SER A 230
ILE A  65
PRO A 109
 None
 1.50A 6dm1B-3evpA:
undetectable
6dm1C-3evpA:
undetectable		 6dm1B-3evpA:
15.52
6dm1C-3evpA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 SER A 244
LEU A 114
SER A 230
ILE A  65
PRO A 109
 None
 1.49A 6dm1B-3evrA:
undetectable
6dm1C-3evrA:
undetectable		 6dm1B-3evrA:
12.35
6dm1C-3evrA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8l NADH OXIDASE

(Acidianus
ambivalens) 		PF07992
(Pyr_redox_2) 		5 MET A  87
SER A  86
LEU A 274
SER A 277
ILE A 288
 None
 1.13A 6dm1B-3h8lA:
undetectable
6dm1C-3h8lA:
2.3		 6dm1B-3h8lA:
11.93
6dm1C-3h8lA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hul HOMOSERINE KINASE

(Listeria
monocytogenes) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 SER A 219
LEU A  84
SER A 243
ILE A 159
PRO A 160
 None
 1.41A 6dm1B-3hulA:
undetectable
6dm1C-3hulA:
undetectable		 6dm1B-3hulA:
13.45
6dm1C-3hulA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		5 LEU A  48
SER A  52
LEU A 114
LYS A 118
ILE A  73
 None
 1.43A 6dm1B-3hveA:
undetectable
6dm1C-3hveA:
undetectable		 6dm1B-3hveA:
12.80
6dm1C-3hveA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwp PHLG

(Pseudomonas
protegens) 		no annotation 5 MET A 212
SER A 196
LEU A  61
ASP A 271
SER A 227
 None
 1.30A 6dm1B-3hwpA:
undetectable
6dm1C-3hwpA:
undetectable		 6dm1B-3hwpA:
15.47
6dm1C-3hwpA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8o KH DOMAIN-CONTAINING
PROTEIN MJ1533

(Methanocaldococcus
jannaschii) 		PF01850
(PIN) 		5 SER A 130
LEU A  86
LEU A  50
ILE A  57
PRO A  58
 None
 1.43A 6dm1B-3i8oA:
undetectable
6dm1C-3i8oA:
2.4		 6dm1B-3i8oA:
20.14
6dm1C-3i8oA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icq EXPORTIN-T

(Schizosaccharomyces
pombe) 		PF08389
(Xpo1) 		5 SER T 340
LEU T 358
LEU T 335
ILE T 423
SER T 380
 None
 1.48A 6dm1B-3icqT:
2.4
6dm1C-3icqT:
3.0		 6dm1B-3icqT:
6.07
6dm1C-3icqT:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4u MAJOR CAPSID PROTEIN

(Bordetella
virus BPP1) 		no annotation 5 MET A  42
LEU A 175
LEU A 183
ILE A 315
PRO A 316
 None
 1.46A 6dm1B-3j4uA:
undetectable
6dm1C-3j4uA:
undetectable		 6dm1B-3j4uA:
12.65
6dm1C-3j4uA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jro FUSION PROTEIN OF
PROTEIN TRANSPORT
PROTEIN SEC13 AND
NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12110
(Nup96) 		5 LEU A1492
LEU A1191
ASP A1192
ILE A1533
PRO A1209
 None
 1.44A 6dm1B-3jroA:
undetectable
6dm1C-3jroA:
2.1		 6dm1B-3jroA:
9.28
6dm1C-3jroA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l07 BIFUNCTIONAL PROTEIN
FOLD

(Francisella
tularensis) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 SER A  45
LEU A  77
ASP A 119
ILE A 103
PRO A 100
 None
None
EDO  A 507 (-3.9A)
None
None
 1.50A 6dm1B-3l07A:
2.9
6dm1C-3l07A:
3.6		 6dm1B-3l07A:
14.75
6dm1C-3l07A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzu PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		5 LEU A 838
ASP A 837
ILE A 739
PRO A 786
SER A 701
 None
 1.38A 6dm1B-3nzuA:
undetectable
6dm1C-3nzuA:
undetectable		 6dm1B-3nzuA:
7.54
6dm1C-3nzuA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ol2 SEMAPHORIN-4D

(Homo sapiens) 		PF00047
(ig)
PF01403
(Sema)
PF01437
(PSI) 		5 LEU A 413
LEU A 312
ASP A 295
ILE A 460
SER A 442
 None
 1.36A 6dm1B-3ol2A:
undetectable
6dm1C-3ol2A:
undetectable		 6dm1B-3ol2A:
8.63
6dm1C-3ol2A:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osr MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Escherichia
coli;
Aequorea
victoria) 		PF01353
(GFP)
PF01547
(SBP_bac_1) 		5 SER A 498
LEU A 368
SER A 484
ILE A 319
PRO A 363
 None
 1.47A 6dm1B-3osrA:
5.6
6dm1C-3osrA:
5.9		 6dm1B-3osrA:
7.63
6dm1C-3osrA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p28 GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		5 SER A  38
LEU A 153
SER A  24
ILE A 104
PRO A 148
 None
 1.47A 6dm1B-3p28A:
undetectable
6dm1C-3p28A:
undetectable		 6dm1B-3p28A:
15.64
6dm1C-3p28A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qo7 SERYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Candida
albicans) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		5 LEU A 191
SER A 406
LEU A 405
ILE A 415
PRO A 428
 None
 1.49A 6dm1B-3qo7A:
6.4
6dm1C-3qo7A:
4.3		 6dm1B-3qo7A:
11.14
6dm1C-3qo7A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u8p CYTOCHROME B562
INTEGRAL FUSION WITH
ENHANCED GREEN
FLUORESCENT PROTEIN

(Escherichia
coli;
Aequorea
victoria) 		PF01353
(GFP)
PF07361
(Cytochrom_B562) 		5 SER A 194
LEU A 309
SER A 180
ILE A 260
PRO A 304
 None
 1.44A 6dm1B-3u8pA:
3.7
6dm1C-3u8pA:
5.9		 6dm1B-3u8pA:
13.66
6dm1C-3u8pA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
halstedii) 		PF00501
(AMP-binding) 		5 LEU A 351
SER A 208
LEU A  25
ILE A 334
PRO A 336
 None
 1.45A 6dm1B-3wv4A:
5.2
6dm1C-3wv4A:
4.4		 6dm1B-3wv4A:
15.05
6dm1C-3wv4A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvi TYPE-2 RESTRICTION
ENZYME HINDIII

(Haemophilus
influenzae) 		PF09518
(RE_HindIII) 		5 LEU A 166
SER A 159
LEU A 160
ASP A 161
PRO A 149
 None
 1.42A 6dm1B-3wviA:
undetectable
6dm1C-3wviA:
undetectable		 6dm1B-3wviA:
15.85
6dm1C-3wviA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
halstedii) 		PF00501
(AMP-binding) 		5 LEU A 351
SER A 208
LEU A  25
ILE A 334
PRO A 336
 None
 1.47A 6dm1B-3wvnA:
5.4
6dm1C-3wvnA:
4.8		 6dm1B-3wvnA:
9.71
6dm1C-3wvnA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4u BIFUNCTIONAL PROTEIN
FOLD

(Acinetobacter
baumannii) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 SER A  46
LEU A  78
ASP A 120
ILE A 104
PRO A 101
 None
 1.37A 6dm1B-4b4uA:
4.5
6dm1C-4b4uA:
4.8		 6dm1B-4b4uA:
12.87
6dm1C-4b4uA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxs VENOM PROTHROMBIN
ACTIVATOR
PSEUTARIN-C
NON-CATALYTIC
SUBUNIT

(Pseudonaja
textilis) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		5 LEU V 297
LEU V 249
ASP V 270
ILE V 299
SER V 272
 None
 1.43A 6dm1B-4bxsV:
undetectable
6dm1C-4bxsV:
undetectable		 6dm1B-4bxsV:
4.95
6dm1C-4bxsV:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcg UNCHARACTERIZED
PROTEIN

(Xanthomonas
euvesicatoria) 		PF13855
(LRR_8) 		5 LEU A 398
LEU A 356
ASP A 357
ILE A 395
PRO A 392
 None
 1.45A 6dm1B-4fcgA:
undetectable
6dm1C-4fcgA:
undetectable		 6dm1B-4fcgA:
15.54
6dm1C-4fcgA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcg UNCHARACTERIZED
PROTEIN

(Xanthomonas
euvesicatoria) 		PF13855
(LRR_8) 		5 SER A 323
LEU A 277
LEU A 330
ILE A 268
PRO A 289
 CL  A 503 (-2.9A)
None
None
None
None
 0.82A 6dm1B-4fcgA:
undetectable
6dm1C-4fcgA:
undetectable		 6dm1B-4fcgA:
15.54
6dm1C-4fcgA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq2 NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		5 LEU M 252
SER M 239
LEU M 174
ASP M 113
SER M 283
 None
 1.26A 6dm1B-4gq2M:
2.6
6dm1C-4gq2M:
5.5		 6dm1B-4gq2M:
6.47
6dm1C-4gq2M:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1

(Bothrops
jararacussu) 		PF00089
(Trypsin) 		5 SER A  20
LEU A  27
ILE A  89
PRO A  67
SER A  43
 None
 1.42A 6dm1B-4gsoA:
undetectable
6dm1C-4gsoA:
undetectable		 6dm1B-4gsoA:
13.19
6dm1C-4gsoA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		5 SER A  75
LEU A 343
LEU A  43
PRO A  67
SER A  58
 None
 1.37A 6dm1B-4iglA:
undetectable
6dm1C-4iglA:
undetectable		 6dm1B-4iglA:
4.21
6dm1C-4iglA:
4.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0m SERINE/THREONINE-PRO
TEIN KINASE
BRI1-LIKE 1

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 563
LEU A 554
ASP A 553
ILE A 675
SER A 647
 None
 1.29A 6dm1B-4j0mA:
undetectable
6dm1C-4j0mA:
undetectable		 6dm1B-4j0mA:
7.66
6dm1C-4j0mA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 709
LEU A 666
ILE A 694
PRO A 695
SER A 691
 None
 1.47A 6dm1B-4m7eA:
undetectable
6dm1C-4m7eA:
undetectable		 6dm1B-4m7eA:
7.47
6dm1C-4m7eA:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mf4 HPCH/HPAI
ALDOLASE/CITRATE
LYASE FAMILY PROTEIN

(Burkholderia
cenocepacia) 		PF03328
(HpcH_HpaI) 		5 MET A 204
SER A 159
LEU A 185
ASP A 184
ILE A 169
 None
None
None
EDO  A 301 (-4.0A)
None
 1.48A 6dm1B-4mf4A:
undetectable
6dm1C-4mf4A:
undetectable		 6dm1B-4mf4A:
14.45
6dm1C-4mf4A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 SER A 597
LEU A 582
LEU A 577
ILE A 567
PRO A 592
 None
 1.43A 6dm1B-4mn8A:
undetectable
6dm1C-4mn8A:
undetectable		 6dm1B-4mn8A:
6.72
6dm1C-4mn8A:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 SER A 597
LEU A 582
LEU A 577
ILE A 567
PRO A 592
 None
 1.36A 6dm1B-4mnaA:
undetectable
6dm1C-4mnaA:
undetectable		 6dm1B-4mnaA:
7.51
6dm1C-4mnaA:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfe GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria;
Vicugna pacos) 		PF01353
(GFP)
PF07686
(V-set) 		5 SER A  86
LEU A 201
SER A  72
ILE A 152
PRO A 196
 None
 1.49A 6dm1B-4pfeA:
undetectable
6dm1C-4pfeA:
undetectable		 6dm1B-4pfeA:
13.89
6dm1C-4pfeA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzh LIC12234

(Leptospira
interrogans) 		PF13855
(LRR_8) 		5 LEU A  87
LEU A  47
ASP A  48
ILE A  84
PRO A  81
 None
None
CL  A 306 ( 4.1A)
None
None
 1.34A 6dm1B-4tzhA:
undetectable
6dm1C-4tzhA:
undetectable		 6dm1B-4tzhA:
18.02
6dm1C-4tzhA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u08 LIC11098

(Leptospira
interrogans) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 393
LEU A 353
ASP A 354
ILE A 390
PRO A 387
 None
 1.48A 6dm1B-4u08A:
undetectable
6dm1C-4u08A:
undetectable		 6dm1B-4u08A:
13.20
6dm1C-4u08A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u09 LIC12759

(Leptospira
interrogans) 		PF13855
(LRR_8) 		5 LEU A 224
LEU A 184
ASP A 185
ILE A 221
PRO A 218
 None
 1.39A 6dm1B-4u09A:
undetectable
6dm1C-4u09A:
undetectable		 6dm1B-4u09A:
8.64
6dm1C-4u09A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 LEU A 397
LEU A 392
LYS A 390
ILE A 379
PRO A 407
 None
 1.29A 6dm1B-4z64A:
undetectable
6dm1C-4z64A:
undetectable		 6dm1B-4z64A:
8.88
6dm1C-4z64A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 SER A 287
LEU A 249
LEU A 294
ILE A 240
PRO A 261
 None
 1.26A 6dm1B-4z64A:
undetectable
6dm1C-4z64A:
undetectable		 6dm1B-4z64A:
8.88
6dm1C-4z64A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zf4 GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		5 SER A  36
LEU A 151
SER A  22
ILE A 102
PRO A 146
 None
 1.45A 6dm1B-4zf4A:
undetectable
6dm1C-4zf4A:
undetectable		 6dm1B-4zf4A:
16.27
6dm1C-4zf4A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwn MONOGLYCERIDE LIPASE

(Saccharomyces
cerevisiae) 		PF12146
(Hydrolase_4) 		5 LEU A 286
SER A 282
ASP A 251
ILE A  55
SER A 123
 None
 1.31A 6dm1B-4zwnA:
3.2
6dm1C-4zwnA:
undetectable		 6dm1B-4zwnA:
12.58
6dm1C-4zwnA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxk SIALIDASE A

(Streptococcus
pneumoniae) 		PF02973
(Sialidase) 		5 SER A 174
LEU A 289
LEU A 146
ILE A 269
SER A 140
 None
 1.33A 6dm1B-4zxkA:
undetectable
6dm1C-4zxkA:
undetectable		 6dm1B-4zxkA:
15.03
6dm1C-4zxkA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
BETA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		PF02239
(Cytochrom_D1) 		5 SER B 203
LEU B 190
ILE B 157
PRO B 178
SER B 174
 None
 1.41A 6dm1B-5c2vB:
undetectable
6dm1C-5c2vB:
undetectable		 6dm1B-5c2vB:
12.50
6dm1C-5c2vB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 LEU D 186
LEU D 360
ASP D 361
ILE D 198
SER D 337
 None
 1.24A 6dm1B-5fl7D:
4.1
6dm1C-5fl7D:
4.1		 6dm1B-5fl7D:
9.77
6dm1C-5fl7D:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		5 SER A  43
LEU A   9
SER A 108
ILE A  29
SER A  95
 None
 1.34A 6dm1B-5hp5A:
undetectable
6dm1C-5hp5A:
undetectable		 6dm1B-5hp5A:
8.24
6dm1C-5hp5A:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz1 PROBABLE LRR
RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
AT4G26540

(Arabidopsis
thaliana) 		PF13855
(LRR_8) 		5 LEU B 293
LEU B 250
ILE B 278
PRO B 279
SER B 275
 None
 1.30A 6dm1B-5hz1B:
undetectable
6dm1C-5hz1B:
undetectable		 6dm1B-5hz1B:
11.87
6dm1C-5hz1B:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
PF01194
(RNA_pol_N) 		5 SER C 237
LEU C 118
SER C 115
ASP J  16
ILE C  46
 None
 1.39A 6dm1B-5ip7C:
undetectable
6dm1C-5ip7C:
undetectable		 6dm1B-5ip7C:
14.29
6dm1C-5ip7C:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 SER A 494
LEU A 456
LEU A 501
ILE A 447
PRO A 468
 None
 1.25A 6dm1B-5ixqA:
undetectable
6dm1C-5ixqA:
undetectable		 6dm1B-5ixqA:
8.44
6dm1C-5ixqA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j3n GREEN FLUORESCENT
PROTEIN,HSDR

(Escherichia
coli;
Aequorea
victoria) 		PF01353
(GFP)
PF12008
(EcoR124_C) 		5 SER A  92
LEU A 207
SER A  78
ILE A 158
PRO A 202
 None
 1.48A 6dm1B-5j3nA:
3.3
6dm1C-5j3nA:
3.6		 6dm1B-5j3nA:
11.08
6dm1C-5j3nA:
11.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 MET A 496
LEU A 751
LEU A 759
ASP A 760
LYS A 763
 None
 0.80A 6dm1B-5l1bA:
40.1
6dm1C-5l1bA:
40.4		 6dm1B-5l1bA:
100.00
6dm1C-5l1bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 MET A 496
LEU A 751
SER A 754
LEU A 759
LYS A 763
 None
 0.96A 6dm1B-5l1bA:
40.1
6dm1C-5l1bA:
40.4		 6dm1B-5l1bA:
100.00
6dm1C-5l1bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 MET A 496
SER A 497
LEU A 751
LEU A 759
LYS A 763
 None
 0.81A 6dm1B-5l1bA:
40.1
6dm1C-5l1bA:
40.4		 6dm1B-5l1bA:
100.00
6dm1C-5l1bA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
3, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL

(Bos taurus;
Bos taurus) 		PF00329
(Complex1_30kDa)
PF00346
(Complex1_49kDa) 		5 LEU D 251
SER C  74
ASP C  77
ILE D 265
SER D 256
 None
 1.42A 6dm1B-5lc5D:
2.9
6dm1C-5lc5D:
2.2		 6dm1B-5lc5D:
9.95
6dm1C-5lc5D:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2n ELONGATOR COMPLEX
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 LEU A 758
SER A 721
LEU A 731
ILE A 755
PRO A 751
 None
 1.34A 6dm1B-5m2nA:
undetectable
6dm1C-5m2nA:
undetectable		 6dm1B-5m2nA:
9.00
6dm1C-5m2nA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		5 LEU A 133
LEU A 148
ASP A 149
LYS A 152
ILE A 260
 None
 1.46A 6dm1B-5m8tA:
undetectable
6dm1C-5m8tA:
undetectable		 6dm1B-5m8tA:
10.31
6dm1C-5m8tA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mbg BETA SUBUNIT OF
PHOTOACTIVATED
ADENYLYL CYCLASE

(Beggiatoa sp.
PS) 		PF00211
(Guanylate_cyc) 		5 LEU A 248
SER A 219
LEU A 220
ASP A 221
ILE A 152
 None
 1.27A 6dm1B-5mbgA:
undetectable
6dm1C-5mbgA:
undetectable		 6dm1B-5mbgA:
17.82
6dm1C-5mbgA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nhs BIFUNCTIONAL PROTEIN
FOLD

(Xanthomonas
albilineans) 		no annotation 5 SER A  56
LEU A 119
ASP A 130
ILE A 113
PRO A 111
 None
 1.37A 6dm1B-5nhsA:
3.7
6dm1C-5nhsA:
4.1		 6dm1B-5nhsA:
19.51
6dm1C-5nhsA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ns8 -

(-) 		no annotation 5 SER A 192
LEU A 305
LEU A 174
ASP A 184
ILE A 261
 None
GOL  A 504 (-3.6A)
None
None
None
 1.32A 6dm1B-5ns8A:
undetectable
6dm1C-5ns8A:
undetectable		 6dm1B-5ns8A:
undetectable
6dm1C-5ns8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjf ALLOPHYCOCYANIN
ALPHA SUBUNIT
ALLOPHYCOCYANIN BETA
SUBUNIT

(Gracilaria
chilensis;
Gracilaria
chilensis) 		PF00502
(Phycobilisome)
PF00502
(Phycobilisome) 		5 LEU B  19
LEU A  89
ASP A  86
ILE B   9
PRO A 103
 None
 1.37A 6dm1B-5tjfB:
2.1
6dm1C-5tjfB:
undetectable		 6dm1B-5tjfB:
19.15
6dm1C-5tjfB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqr POLYCOMB PROTEIN EED

(Chaetomium
thermophilum) 		PF00400
(WD40) 		5 LEU A 111
SER A  98
LEU A 144
ASP A 143
PRO A  47
 None
 1.30A 6dm1B-5tqrA:
undetectable
6dm1C-5tqrA:
undetectable		 6dm1B-5tqrA:
8.43
6dm1C-5tqrA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f DNA REPLICATION
LICENSING FACTOR
MCM7

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 MET 7 600
SER 7 723
ASP 7 427
PRO 7 580
SER 7 726
 None
 1.03A 6dm1B-5v8f7:
undetectable
6dm1C-5v8f7:
undetectable		 6dm1B-5v8f7:
6.52
6dm1C-5v8f7:
6.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		7 MET A 496
SER A 497
LEU A 751
SER A 754
LEU A 759
ASP A 760
LYS A 763
 None
 0.82A 6dm1B-5welA:
53.1
6dm1C-5welA:
53.6		 6dm1B-5welA:
100.00
6dm1C-5welA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		7 MET A 496
SER A 497
LEU A 751
SER A 754
LEU A 759
ASP A 760
LYS A 763
 CYZ  A1302 (-4.3A)
CYZ  A1302 (-3.2A)
None
CYZ  A1302 ( 4.1A)
None
CYZ  A1302 (-3.8A)
CYZ  A1302 (-2.9A)
 0.44A 6dm1B-5weoA:
55.9
6dm1C-5weoA:
56.1		 6dm1B-5weoA:
100.00
6dm1C-5weoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gl3 -

(-) 		no annotation 5 SER A 607
LEU A 569
ASP A 568
ILE A 329
PRO A 370
 None
 1.40A 6dm1B-6gl3A:
undetectable
6dm1C-6gl3A:
undetectable		 6dm1B-6gl3A:
undetectable
6dm1C-6gl3A:
undetectable