SIMILAR PATTERNS OF AMINO ACIDS FOR 6DM0_B_CYZB1302_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5f PROTEIN (CARDOSIN A)

(Cynara
cardunculus) 		PF00026
(Asp) 		5 SER A  61
LEU A  38
ILE A  18
SER A  88
GLY A  19
 None
 1.30A 6dm0B-1b5fA:
undetectable
6dm0C-1b5fA:
undetectable		 6dm0B-1b5fA:
16.91
6dm0C-1b5fA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89

(Zoogloea
ramigera) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 SER A 296
LEU A 358
LEU A 377
ILE A 389
GLY A 373
 None
None
SCY  A  89 ( 3.8A)
None
None
 1.27A 6dm0B-1dm3A:
undetectable
6dm0C-1dm3A:
undetectable		 6dm0B-1dm3A:
12.34
6dm0C-1dm3A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		5 LEU A 301
LEU A 416
ASP A 253
ILE A 290
GLY A 291
 None
 1.27A 6dm0B-1e1cA:
3.1
6dm0C-1e1cA:
4.0		 6dm0B-1e1cA:
7.10
6dm0C-1e1cA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fon PROCARBOXYPEPTIDASE
A-S6

(Bos taurus) 		PF00089
(Trypsin) 		5 LEU A 191
ASP A  93
ILE A 129
SER A 187
GLY A 185
 None
 1.30A 6dm0B-1fonA:
undetectable
6dm0C-1fonA:
undetectable		 6dm0B-1fonA:
15.65
6dm0C-1fonA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gwi CYTOCHROME P450
154C1

(Streptomyces
coelicolor) 		PF00067
(p450) 		5 LEU A 151
LEU A 131
ASP A 132
ILE A 123
GLY A 121
 None
 1.09A 6dm0B-1gwiA:
undetectable
6dm0C-1gwiA:
undetectable		 6dm0B-1gwiA:
9.98
6dm0C-1gwiA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j8m SIGNAL RECOGNITION
54 KDA PROTEIN

(Acidianus
ambivalens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 LEU F 259
LEU F   4
ASP F   5
ILE F 246
GLY F 273
 None
 1.26A 6dm0B-1j8mF:
3.4
6dm0C-1j8mF:
3.5		 6dm0B-1j8mF:
13.68
6dm0C-1j8mF:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdm PROPHYTEPSIN

(Hordeum vulgare) 		PF00026
(Asp)
PF03489
(SapB_2)
PF05184
(SapB_1) 		5 SER A  66
LEU A  42
ASP A 103
ILE A  22
SER A  93
 None
 1.31A 6dm0B-1qdmA:
undetectable
6dm0C-1qdmA:
undetectable		 6dm0B-1qdmA:
10.35
6dm0C-1qdmA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4c PROTEIN HI0227

(Haemophilus
influenzae) 		PF04074
(DUF386) 		5 LEU A  74
LEU A  31
ASP A  30
ILE A 143
PRO A  52
 None
 1.31A 6dm0B-1s4cA:
undetectable
6dm0C-1s4cA:
undetectable		 6dm0B-1s4cA:
14.94
6dm0C-1s4cA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smr RENIN

(Mus musculus) 		PF00026
(Asp) 		5 SER A  61
LEU A  38
ILE A  18
SER A  88
GLY A  19
 None
 1.27A 6dm0B-1smrA:
undetectable
6dm0C-1smrA:
undetectable		 6dm0B-1smrA:
11.88
6dm0C-1smrA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 SER A 222
LEU A 181
ILE A  92
PRO A 190
GLY A  88
 None
 1.31A 6dm0B-1uaaA:
4.1
6dm0C-1uaaA:
3.3		 6dm0B-1uaaA:
9.67
6dm0C-1uaaA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpo RHO TRANSCRIPTION
TERMINATION FACTOR

(Escherichia
coli) 		PF00006
(ATP-synt_ab)
PF07497
(Rho_RNA_bind)
PF07498
(Rho_N) 		5 LEU A  55
LEU A 113
ILE A  57
SER A  82
GLY A  61
 None
None
None
U  G   1 ( 3.2A)
None
 1.30A 6dm0B-1xpoA:
2.0
6dm0C-1xpoA:
2.3		 6dm0B-1xpoA:
10.92
6dm0C-1xpoA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zt2 DNA PRIMASE LARGE
SUBUNIT

(Sulfolobus
solfataricus) 		PF04104
(DNA_primase_lrg) 		5 LEU B  72
LEU B  18
ASP B  15
ILE B 199
PRO B 200
 None
None
None
None
SO4  B 218 (-4.0A)
 1.29A 6dm0B-1zt2B:
2.2
6dm0C-1zt2B:
undetectable		 6dm0B-1zt2B:
15.08
6dm0C-1zt2B:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bw3 TRANSPOSASE
TRANSPOSASE

(Musca
domestica;
Musca domestica) 		PF05699
(Dimer_Tnp_hAT)
PF10683
(DBD_Tnp_Hermes)
PF10683
(DBD_Tnp_Hermes) 		5 LEU A 141
LEU A 147
ILE B 118
SER B 110
GLY B 114
 None
 1.26A 6dm0B-2bw3A:
2.5
6dm0C-2bw3A:
undetectable		 6dm0B-2bw3A:
8.44
6dm0C-2bw3A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbz MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Homo sapiens) 		PF00005
(ABC_tran) 		5 MET A 829
SER A 828
LEU A 673
ILE A 811
PRO A 794
 None
 1.26A 6dm0B-2cbzA:
undetectable
6dm0C-2cbzA:
undetectable		 6dm0B-2cbzA:
18.22
6dm0C-2cbzA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF01368
(DHH)
PF02833
(DHHA2) 		5 LEU A 139
ASP A 147
ILE A  19
PRO A  51
SER A  14
 None
MN  A 502 (-2.6A)
None
None
MN  A 501 ( 3.7A)
 1.05A 6dm0B-2eb0A:
undetectable
6dm0C-2eb0A:
undetectable		 6dm0B-2eb0A:
12.96
6dm0C-2eb0A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2

(Archaeoglobus
fulgidus) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 SER A 676
LEU A 711
LEU A 691
ILE A 776
GLY A 669
 None
 1.28A 6dm0B-2f3oA:
3.0
6dm0C-2f3oA:
undetectable		 6dm0B-2f3oA:
8.27
6dm0C-2f3oA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g02 NISIN BIOSYNTHESIS
PROTEIN NISC

(Lactococcus
lactis) 		PF05147
(LANC_like) 		5 LEU A  77
ILE A  94
PRO A  44
SER A  89
GLY A  93
 None
 1.21A 6dm0B-2g02A:
undetectable
6dm0C-2g02A:
2.8		 6dm0B-2g02A:
13.41
6dm0C-2g02A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g1s RENIN

(Homo sapiens) 		PF00026
(Asp) 		5 LEU A 148
ASP A 177
ILE A  97
SER A   4
GLY A  95
 None
 1.30A 6dm0B-2g1sA:
undetectable
6dm0C-2g1sA:
undetectable		 6dm0B-2g1sA:
13.84
6dm0C-2g1sA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum) 		PF00440
(TetR_N) 		5 SER A  78
LEU A 160
ASP A  71
ILE A 156
SER A 130
 None
EDO  A 197 ( 4.8A)
None
None
None
 1.21A 6dm0B-2hytA:
2.0
6dm0C-2hytA:
undetectable		 6dm0B-2hytA:
14.78
6dm0C-2hytA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n0s FE-HYDROGENASE
FERREDOXIN,
CHLOROPLASTIC

(Chlamydomonas
reinhardtii;
Chlamydomonas
reinhardtii) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF00111
(Fer2) 		5 SER B  44
LEU B  33
ASP B  32
PRO A 378
GLY A 383
 None
None
None
FES  B 101 ( 4.4A)
None
 1.14A 6dm0B-2n0sB:
undetectable
6dm0C-2n0sB:
undetectable		 6dm0B-2n0sB:
19.77
6dm0C-2n0sB:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np5 TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		5 LEU A 188
LEU A 153
ILE A 141
SER A 135
GLY A 140
 None
 1.09A 6dm0B-2np5A:
undetectable
6dm0C-2np5A:
undetectable		 6dm0B-2np5A:
17.73
6dm0C-2np5A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE

(Nostoc
punctiforme) 		PF00221
(Lyase_aromatic) 		5 SER A 331
LEU A 382
LEU A 375
ILE A 323
GLY A 324
 None
 0.95A 6dm0B-2nyfA:
2.8
6dm0C-2nyfA:
2.5		 6dm0B-2nyfA:
9.72
6dm0C-2nyfA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcl LIPOPROTEIN-RELEASIN
G SYSTEM ATP-BINDING
PROTEIN LOLD

(Aquifex
aeolicus) 		PF00005
(ABC_tran) 		5 LEU A  50
LEU A  63
ILE A  10
PRO A  56
GLY A  59
 None
 1.31A 6dm0B-2pclA:
2.3
6dm0C-2pclA:
undetectable		 6dm0B-2pclA:
17.59
6dm0C-2pclA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9v MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00595
(PDZ) 		5 MET A 838
SER A 837
LEU A 882
ILE A 867
GLY A 885
 None
 1.28A 6dm0B-2q9vA:
undetectable
6dm0C-2q9vA:
undetectable		 6dm0B-2q9vA:
17.20
6dm0C-2q9vA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt3 N-ISOPROPYLAMMELIDE
ISOPROPYL
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		5 LEU A 367
LEU A 120
ASP A 152
ILE A  25
GLY A  27
 None
 1.08A 6dm0B-2qt3A:
2.1
6dm0C-2qt3A:
undetectable		 6dm0B-2qt3A:
11.11
6dm0C-2qt3A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r79 PERIPLASMIC BINDING
PROTEIN

(Pseudomonas
aeruginosa) 		PF01497
(Peripla_BP_2) 		5 LEU A 129
LEU A 122
ILE A  89
SER A 114
GLY A  90
 None
 0.98A 6dm0B-2r79A:
3.5
6dm0C-2r79A:
3.3		 6dm0B-2r79A:
10.18
6dm0C-2r79A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06460
(NSP13) 		5 LEU A 161
LEU A 275
ILE A 167
SER A 188
GLY A 208
 None
None
None
MG  A1296 ( 4.6A)
None
 1.27A 6dm0B-2xyqA:
undetectable
6dm0C-2xyqA:
4.2		 6dm0B-2xyqA:
13.45
6dm0C-2xyqA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE

(Mycoplasma
pneumoniae) 		PF00579
(tRNA-synt_1b) 		5 LEU A  62
LEU A 316
ASP A  83
ILE A   9
GLY A   8
 None
None
None
WSA  A1350 ( 4.3A)
WSA  A1350 (-3.7A)
 1.24A 6dm0B-2yy5A:
undetectable
6dm0C-2yy5A:
undetectable		 6dm0B-2yy5A:
13.18
6dm0C-2yy5A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zau SELENIDE, WATER
DIKINASE

(Aquifex
aeolicus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 LEU A 288
LEU A 226
ILE A 176
PRO A 263
GLY A 175
 None
None
None
PO4  A 902 (-4.7A)
None
 1.31A 6dm0B-2zauA:
undetectable
6dm0C-2zauA:
2.2		 6dm0B-2zauA:
12.87
6dm0C-2zauA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zl5 58 KD CAPSID PROTEIN

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		5 LEU A 304
ASP A 305
ILE A 359
PRO A 354
GLY A 357
 ACT  A 520 ( 4.0A)
None
None
None
None
 1.31A 6dm0B-2zl5A:
undetectable
6dm0C-2zl5A:
undetectable		 6dm0B-2zl5A:
15.16
6dm0C-2zl5A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8t ADENYLATE
ISOPENTENYLTRANSFERA
SE

(Humulus lupulus) 		PF01715
(IPPT) 		5 SER A  61
LEU A 279
LEU A 137
ILE A 276
GLY A  37
 None
 1.28A 6dm0B-3a8tA:
undetectable
6dm0C-3a8tA:
undetectable		 6dm0B-3a8tA:
12.94
6dm0C-3a8tA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abz BETA-GLUCOSIDASE I

(Kluyveromyces
marxianus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF07691
(PA14)
PF14310
(Fn3-like) 		5 LEU A 656
LEU A 375
ILE A 652
PRO A 367
GLY A 649
 None
 1.17A 6dm0B-3abzA:
3.8
6dm0C-3abzA:
4.5		 6dm0B-3abzA:
6.93
6dm0C-3abzA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ada SARCOSINE OXIDASE
BETA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01266
(DAO) 		5 LEU B 393
ASP B 395
ILE B 242
SER B 335
GLY B 351
 None
 1.14A 6dm0B-3adaB:
undetectable
6dm0C-3adaB:
2.0		 6dm0B-3adaB:
12.07
6dm0C-3adaB:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT
MEMBRANE-BOUND
HYDROGENASE SMALL
SUBUNIT

(Hydrogenovibrio
marinus;
Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 MET B  55
LEU B  43
ASP B  49
ILE A 171
PRO A 134
 None
 1.13A 6dm0B-3ayxB:
4.3
6dm0C-3ayxB:
4.4		 6dm0B-3ayxB:
13.78
6dm0C-3ayxB:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT
MEMBRANE-BOUND
HYDROGENASE SMALL
SUBUNIT

(Hydrogenovibrio
marinus;
Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 MET B  55
LEU B  43
LEU B  48
ASP B  49
ILE A 171
 None
 1.25A 6dm0B-3ayxB:
4.3
6dm0C-3ayxB:
4.4		 6dm0B-3ayxB:
13.78
6dm0C-3ayxB:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc1 PUTATIVE
ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bacillus
halodurans) 		PF16499
(Melibiase_2) 		5 LEU A 426
LEU A 385
ASP A 386
ILE A 416
SER A 413
 None
 1.21A 6dm0B-3cc1A:
undetectable
6dm0C-3cc1A:
undetectable		 6dm0B-3cc1A:
10.50
6dm0C-3cc1A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cxm URACIL-DNA
GLYCOSYLASE

(Leishmania
naiffi) 		PF03167
(UDG) 		5 LEU A 169
ASP A 170
LYS A 173
ILE A 140
GLY A 138
 None
 0.95A 6dm0B-3cxmA:
undetectable
6dm0C-3cxmA:
undetectable		 6dm0B-3cxmA:
16.73
6dm0C-3cxmA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewb 2-ISOPROPYLMALATE
SYNTHASE

(Listeria
monocytogenes) 		PF00682
(HMGL-like) 		5 LEU X 240
LEU X 247
LYS X 251
ILE X  39
GLY X  38
 None
 1.08A 6dm0B-3ewbX:
2.0
6dm0C-3ewbX:
2.7		 6dm0B-3ewbX:
12.29
6dm0C-3ewbX:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnd CHITINASE

(Bacteroides
thetaiotaomicron) 		PF00704
(Glyco_hydro_18) 		5 SER A 114
LEU A 324
LEU A  55
ASP A  56
ILE A 321
 None
 1.10A 6dm0B-3fndA:
2.8
6dm0C-3fndA:
3.0		 6dm0B-3fndA:
14.34
6dm0C-3fndA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3get HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00155
(Aminotran_1_2) 		5 SER A 225
ASP A 190
ILE A  86
SER A  90
GLY A  87
 LLP  A 226 ( 2.4A)
LLP  A 226 ( 2.6A)
None
LLP  A 226 ( 2.9A)
None
 1.13A 6dm0B-3getA:
4.1
6dm0C-3getA:
4.6		 6dm0B-3getA:
13.92
6dm0C-3getA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3get HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00155
(Aminotran_1_2) 		5 SER A 225
LEU A  73
ILE A  86
SER A  90
GLY A  87
 LLP  A 226 ( 2.4A)
None
None
LLP  A 226 ( 2.9A)
None
 1.10A 6dm0B-3getA:
4.1
6dm0C-3getA:
4.6		 6dm0B-3getA:
13.92
6dm0C-3getA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2

(Trypanosoma
brucei) 		PF01704
(UDPGP) 		5 LEU A 475
LEU A 433
ASP A 386
ILE A 469
GLY A 448
 None
 1.21A 6dm0B-3gueA:
undetectable
6dm0C-3gueA:
undetectable		 6dm0B-3gueA:
11.02
6dm0C-3gueA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyc PUTATIVE GLYCOSIDE
HYDROLASE

(Parabacteroides
distasonis) 		PF12876
(Cellulase-like) 		5 LEU A 167
LEU A 184
ILE A 179
SER A 139
GLY A 137
 None
 1.13A 6dm0B-3gycA:
undetectable
6dm0C-3gycA:
undetectable		 6dm0B-3gycA:
13.75
6dm0C-3gycA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6t GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		5 MET A 107
SER A 108
LEU A 239
LEU A 247
LYS A 251
 None
CYZ  A 265 (-2.8A)
CYZ  A 265 (-4.7A)
CYZ  A 265 (-4.3A)
CYZ  A 265 ( 4.4A)
 0.76A 6dm0B-3h6tA:
35.3
6dm0C-3h6tA:
21.2		 6dm0B-3h6tA:
15.44
6dm0C-3h6tA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iha SALT-TOLERANT
GLUTAMINASE

(Micrococcus
luteus) 		PF04960
(Glutaminase) 		5 SER A 288
LEU A 298
LEU A  16
ILE A 275
GLY A 276
 None
 1.19A 6dm0B-3ihaA:
undetectable
6dm0C-3ihaA:
undetectable		 6dm0B-3ihaA:
9.43
6dm0C-3ihaA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iqd OCTOPINE
DEHYDROGENASE

(Pecten maximus) 		PF02317
(Octopine_DH) 		5 LEU B 391
LEU B 269
ASP B 272
PRO B 383
GLY B 339
 None
 1.24A 6dm0B-3iqdB:
5.0
6dm0C-3iqdB:
5.1		 6dm0B-3iqdB:
11.28
6dm0C-3iqdB:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 SER B 314
LEU B 410
ASP B 444
ILE B 373
GLY B 367
 None
 1.11A 6dm0B-3jcmB:
undetectable
6dm0C-3jcmB:
undetectable		 6dm0B-3jcmB:
9.73
6dm0C-3jcmB:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Saccharomyces
cerevisiae) 		no annotation 5 SER B 518
LEU B 477
LEU B 498
ILE B 474
GLY B 473
 None
 1.11A 6dm0B-3kx2B:
2.3
6dm0C-3kx2B:
2.3		 6dm0B-3kx2B:
7.65
6dm0C-3kx2B:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzp ARGININE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF02784
(Orn_Arg_deC_N) 		5 LEU A  38
ASP A  41
ILE A 540
PRO A  29
GLY A 544
 None
 1.20A 6dm0B-3nzpA:
undetectable
6dm0C-3nzpA:
undetectable		 6dm0B-3nzpA:
10.04
6dm0C-3nzpA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1t ENOYL-COA HYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		5 SER A 134
LEU A 180
LEU A 125
ILE A 188
GLY A 189
 None
 1.16A 6dm0B-3q1tA:
2.0
6dm0C-3q1tA:
undetectable		 6dm0B-3q1tA:
13.87
6dm0C-3q1tA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk8 ENOYL-COA HYDRATASE
ECHA15

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 SER A 128
LEU A 174
LEU A 119
ILE A 182
GLY A 183
 None
 1.23A 6dm0B-3qk8A:
2.0
6dm0C-3qk8A:
undetectable		 6dm0B-3qk8A:
14.71
6dm0C-3qk8A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r24 2'-O-METHYL
TRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06460
(NSP13) 		5 LEU A 161
LEU A 275
ILE A 167
SER A 188
GLY A 208
 None
 1.27A 6dm0B-3r24A:
3.7
6dm0C-3r24A:
2.4		 6dm0B-3r24A:
11.05
6dm0C-3r24A:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thw DNA MISMATCH REPAIR
PROTEIN MSH3

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05192
(MutS_III) 		5 SER B 561
LEU B 636
LEU B 819
ILE B 632
GLY B 615
 None
 1.16A 6dm0B-3thwB:
4.0
6dm0C-3thwB:
2.5		 6dm0B-3thwB:
6.13
6dm0C-3thwB:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vxc PUTATIVE
SUGAR-BINDING
LIPOPROTEIN

(Streptomyces
thermoviolaceus) 		PF01547
(SBP_bac_1) 		5 LEU A 213
LEU A 181
ILE A 217
SER A 310
GLY A 314
 None
 1.20A 6dm0B-3vxcA:
5.7
6dm0C-3vxcA:
3.1		 6dm0B-3vxcA:
10.26
6dm0C-3vxcA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w94 ENTEROPEPTIDASE-1

(Oryzias latipes) 		PF00089
(Trypsin) 		5 LEU A 946
ASP A 973
LYS A 795
ILE A 994
GLY A 995
 None
 1.25A 6dm0B-3w94A:
undetectable
6dm0C-3w94A:
undetectable		 6dm0B-3w94A:
13.54
6dm0C-3w94A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zc4 SSO1398

(Sulfolobus
solfataricus) 		no annotation 5 LEU A  22
LEU A  54
ILE A  34
PRO A  36
GLY A  32
 None
 1.10A 6dm0B-3zc4A:
undetectable
6dm0C-3zc4A:
undetectable		 6dm0B-3zc4A:
18.12
6dm0C-3zc4A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcg UNCHARACTERIZED
PROTEIN

(Xanthomonas
euvesicatoria) 		PF13855
(LRR_8) 		5 SER A 323
LEU A 277
LEU A 330
ILE A 268
PRO A 289
 CL  A 503 (-2.9A)
None
None
None
None
 0.81A 6dm0B-4fcgA:
undetectable
6dm0C-4fcgA:
undetectable		 6dm0B-4fcgA:
15.54
6dm0C-4fcgA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fiu HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 LEU A  37
ASP A  36
ILE A 376
SER A  34
GLY A 318
 None
 1.13A 6dm0B-4fiuA:
undetectable
6dm0C-4fiuA:
undetectable		 6dm0B-4fiuA:
9.51
6dm0C-4fiuA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fuu LEUCINE
AMINOPEPTIDASE

(Bacteroides
thetaiotaomicron) 		PF04389
(Peptidase_M28) 		5 LEU A 121
LEU A  80
ILE A 119
SER A 110
GLY A 172
 None
 1.28A 6dm0B-4fuuA:
2.2
6dm0C-4fuuA:
undetectable		 6dm0B-4fuuA:
14.44
6dm0C-4fuuA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fuu LEUCINE
AMINOPEPTIDASE

(Bacteroides
thetaiotaomicron) 		PF04389
(Peptidase_M28) 		5 LEU A 121
LEU A  80
PRO A 169
SER A 110
GLY A 172
 None
 1.24A 6dm0B-4fuuA:
2.2
6dm0C-4fuuA:
undetectable		 6dm0B-4fuuA:
14.44
6dm0C-4fuuA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8k 2-5A-DEPENDENT
RIBONUCLEASE

(Homo sapiens) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 LEU A 279
LEU A 304
ASP A 303
LYS A 326
GLY A 273
 None
 1.08A 6dm0B-4g8kA:
undetectable
6dm0C-4g8kA:
undetectable		 6dm0B-4g8kA:
11.42
6dm0C-4g8kA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ge0 UNCHARACTERIZED
PROTEIN C22E12.03C

(Schizosaccharomyces
pombe) 		PF01965
(DJ-1_PfpI) 		5 LEU A 155
LEU A 171
ILE A 127
SER A 158
GLY A 129
 None
 1.22A 6dm0B-4ge0A:
4.0
6dm0C-4ge0A:
3.9		 6dm0B-4ge0A:
15.90
6dm0C-4ge0A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE

(Rhizobium etli) 		PF02826
(2-Hacid_dh_C) 		5 LEU A  75
LEU A   8
ILE A  78
PRO A  62
GLY A  60
 None
 0.80A 6dm0B-4hy3A:
2.1
6dm0C-4hy3A:
3.5		 6dm0B-4hy3A:
13.22
6dm0C-4hy3A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0m SERINE/THREONINE-PRO
TEIN KINASE
BRI1-LIKE 1

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 563
LEU A 554
ASP A 553
ILE A 675
SER A 647
 None
 1.30A 6dm0B-4j0mA:
undetectable
6dm0C-4j0mA:
undetectable		 6dm0B-4j0mA:
7.66
6dm0C-4j0mA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j34 KYNURENINE
3-MONOOXYGENASE

(Saccharomyces
cerevisiae) 		PF01494
(FAD_binding_3) 		5 SER A  64
LEU A 112
LEU A  19
ILE A  54
GLY A  58
 None
 1.24A 6dm0B-4j34A:
3.3
6dm0C-4j34A:
3.3		 6dm0B-4j34A:
17.61
6dm0C-4j34A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kgk THG1-LIKE
UNCHARACTERIZED
PROTEIN

(Bacillus
thuringiensis) 		PF04446
(Thg1) 		5 MET A  23
LEU A  19
ILE A  64
SER A  91
GLY A  66
 None
 1.10A 6dm0B-4kgkA:
undetectable
6dm0C-4kgkA:
undetectable		 6dm0B-4kgkA:
16.88
6dm0C-4kgkA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kps HEMAGGLUTININ
HEMAGGLUTININ

(Influenza A
virus;
Influenza A
virus) 		PF00509
(Hemagglutinin)
PF00509
(Hemagglutinin) 		5 LEU A  37
ASP A  36
ILE B  48
SER A  34
GLY A 320
 None
 1.17A 6dm0B-4kpsA:
undetectable
6dm0C-4kpsA:
undetectable		 6dm0B-4kpsA:
13.06
6dm0C-4kpsA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kyq PHOSPHOGLUCAN
PHOSPHATASE LSF2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00782
(DSPc) 		5 LEU A 216
ASP A 242
ILE A 205
PRO A 231
GLY A 202
 None
 1.18A 6dm0B-4kyqA:
undetectable
6dm0C-4kyqA:
2.4		 6dm0B-4kyqA:
18.89
6dm0C-4kyqA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmv GLUTATHIONE
TRANSFERASE

(Phanerochaete
chrysosporium) 		PF13417
(GST_N_3) 		5 SER A 212
LEU A  95
ILE A  91
PRO A  74
GLY A  88
 None
 1.05A 6dm0B-4lmvA:
undetectable
6dm0C-4lmvA:
undetectable		 6dm0B-4lmvA:
14.86
6dm0C-4lmvA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 SER A 307
LEU A 269
LEU A 314
ILE A 260
GLY A 261
 None
 1.04A 6dm0B-4mn8A:
undetectable
6dm0C-4mn8A:
undetectable		 6dm0B-4mn8A:
6.72
6dm0C-4mn8A:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 SER A 307
LEU A 269
LEU A 314
ILE A 260
GLY A 261
 None
 1.06A 6dm0B-4mnaA:
undetectable
6dm0C-4mnaA:
undetectable		 6dm0B-4mnaA:
7.51
6dm0C-4mnaA:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n11 GLUTAREDOXIN

(Plasmodium
falciparum) 		PF00462
(Glutaredoxin) 		5 LEU A  39
ASP A  96
ILE A  78
PRO A  76
GLY A  87
 None
None
None
MPO  A 201 (-3.8A)
MPO  A 201 (-3.5A)
 1.24A 6dm0B-4n11A:
undetectable
6dm0C-4n11A:
undetectable		 6dm0B-4n11A:
17.82
6dm0C-4n11A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whm UDP-GLUCOSE:ANTHOCYA
NIDIN
3-O-GLUCOSYLTRANSFER
ASE

(Clitoria
ternatea) 		PF00201
(UDPGT) 		5 LEU A 144
LEU A 183
ASP A 184
ILE A 370
GLY A 369
 None
None
None
None
GOL  A1003 (-3.7A)
 0.90A 6dm0B-4whmA:
5.0
6dm0C-4whmA:
2.9		 6dm0B-4whmA:
11.94
6dm0C-4whmA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		5 SER A1071
LEU A1145
ILE A1084
PRO A1019
GLY A1017
 None
 1.20A 6dm0B-4xqkA:
3.3
6dm0C-4xqkA:
3.4		 6dm0B-4xqkA:
4.49
6dm0C-4xqkA:
4.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzr POLYKETIDE
BIOSYNTHESIS
CYTOCHROME P450 PKSS

(Bacillus
subtilis) 		PF00067
(p450) 		5 LEU A 149
LEU A 130
ASP A 131
ILE A 122
GLY A 120
 LEU  A 149 ( 0.5A)
LEU  A 130 ( 0.6A)
ASP  A 131 ( 0.6A)
ILE  A 122 ( 0.7A)
GLY  A 120 ( 0.0A)
 0.94A 6dm0B-4yzrA:
undetectable
6dm0C-4yzrA:
undetectable		 6dm0B-4yzrA:
14.24
6dm0C-4yzrA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 LEU A 397
LEU A 392
LYS A 390
ILE A 379
PRO A 407
 None
 1.29A 6dm0B-4z64A:
undetectable
6dm0C-4z64A:
undetectable		 6dm0B-4z64A:
8.88
6dm0C-4z64A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 SER A 287
LEU A 249
LEU A 294
ILE A 240
PRO A 261
 None
 1.26A 6dm0B-4z64A:
undetectable
6dm0C-4z64A:
undetectable		 6dm0B-4z64A:
8.88
6dm0C-4z64A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 SER A1093
ILE A 884
PRO A 933
SER A 952
GLY A 885
 None
 1.24A 6dm0B-5a22A:
2.7
6dm0C-5a22A:
undetectable		 6dm0B-5a22A:
3.54
6dm0C-5a22A:
3.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d39 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		5 SER A 531
LEU A 615
ILE A 606
SER A 627
GLY A 603
 None
 1.26A 6dm0B-5d39A:
undetectable
6dm0C-5d39A:
undetectable		 6dm0B-5d39A:
11.60
6dm0C-5d39A:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE

(Pyrococcus
horikoshii) 		PF00004
(AAA) 		5 MET A 306
ASP A 299
ILE A 285
PRO A 277
GLY A 281
 None
None
ADP  A 401 (-4.2A)
None
None
 1.21A 6dm0B-5eqtA:
undetectable
6dm0C-5eqtA:
undetectable		 6dm0B-5eqtA:
17.12
6dm0C-5eqtA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 LEU D 186
LEU D 360
ASP D 361
ILE D 198
SER D 337
 None
 1.22A 6dm0B-5fl7D:
4.0
6dm0C-5fl7D:
4.3		 6dm0B-5fl7D:
9.77
6dm0C-5fl7D:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		6 SER B 388
LEU B 350
LEU B 395
ILE B 341
PRO B 362
GLY B 342
 None
 1.25A 6dm0B-5gqrB:
undetectable
6dm0C-5gqrB:
undetectable		 6dm0B-5gqrB:
8.32
6dm0C-5gqrB:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs0 TOLL-LIKE RECEPTOR 3

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 271
LEU A 281
ILE A 250
SER A 254
GLY A 225
 None
 1.26A 6dm0B-5gs0A:
undetectable
6dm0C-5gs0A:
undetectable		 6dm0B-5gs0A:
9.93
6dm0C-5gs0A:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT DELTA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		5 SER d  95
LEU d 135
LEU d 447
ILE d 411
GLY d 413
 None
 1.23A 6dm0B-5gw5d:
undetectable
6dm0C-5gw5d:
undetectable		 6dm0B-5gw5d:
9.73
6dm0C-5gw5d:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz1 PROBABLE LRR
RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
AT4G26540

(Arabidopsis
thaliana) 		PF13855
(LRR_8) 		5 LEU B 293
LEU B 250
ILE B 278
PRO B 279
SER B 275
 None
 1.29A 6dm0B-5hz1B:
undetectable
6dm0C-5hz1B:
undetectable		 6dm0B-5hz1B:
11.87
6dm0C-5hz1B:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz1 PROBABLE LRR
RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
AT4G26540

(Arabidopsis
thaliana) 		PF13855
(LRR_8) 		5 SER B 329
LEU B 291
LEU B 336
ILE B 282
GLY B 283
 None
 0.76A 6dm0B-5hz1B:
undetectable
6dm0C-5hz1B:
undetectable		 6dm0B-5hz1B:
11.87
6dm0C-5hz1B:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 SER A 494
LEU A 456
LEU A 501
ILE A 447
PRO A 468
 None
 1.25A 6dm0B-5ixqA:
undetectable
6dm0C-5ixqA:
undetectable		 6dm0B-5ixqA:
8.44
6dm0C-5ixqA:
8.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 MET A 496
LEU A 751
LEU A 759
ASP A 760
LYS A 763
 None
 0.80A 6dm0B-5l1bA:
40.1
6dm0C-5l1bA:
42.9		 6dm0B-5l1bA:
100.00
6dm0C-5l1bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 MET A 496
SER A 497
LEU A 751
LEU A 759
LYS A 763
 None
 0.77A 6dm0B-5l1bA:
40.1
6dm0C-5l1bA:
42.9		 6dm0B-5l1bA:
100.00
6dm0C-5l1bA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2n ELONGATOR COMPLEX
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 LEU A 758
LEU A 731
ILE A 755
PRO A 751
GLY A 727
 None
 1.06A 6dm0B-5m2nA:
undetectable
6dm0C-5m2nA:
undetectable		 6dm0B-5m2nA:
9.00
6dm0C-5m2nA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfg PROCARDOSIN-B,PROCAR
DOSIN-B

(Cynara
cardunculus) 		no annotation 5 SER A 110
LEU A  86
ILE A  66
SER A 137
GLY A  67
 None
 1.25A 6dm0B-5nfgA:
undetectable
6dm0C-5nfgA:
undetectable		 6dm0B-5nfgA:
11.50
6dm0C-5nfgA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogz -

(-) 		no annotation 5 SER A 354
LEU A 255
LEU A 223
ILE A 288
GLY A 218
 None
 1.29A 6dm0B-5ogzA:
undetectable
6dm0C-5ogzA:
undetectable		 6dm0B-5ogzA:
undetectable
6dm0C-5ogzA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		6 MET A 496
SER A 497
LEU A 751
LEU A 759
ASP A 760
LYS A 763
 None
 0.81A 6dm0B-5welA:
53.0
6dm0C-5welA:
43.2		 6dm0B-5welA:
100.00
6dm0C-5welA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		6 MET A 496
SER A 497
LEU A 751
LEU A 759
ASP A 760
LYS A 763
 CYZ  A1302 (-4.3A)
CYZ  A1302 (-3.2A)
None
None
CYZ  A1302 (-3.8A)
CYZ  A1302 (-2.9A)
 0.49A 6dm0B-5weoA:
55.9
6dm0C-5weoA:
45.3		 6dm0B-5weoA:
100.00
6dm0C-5weoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli) 		PF00795
(CN_hydrolase) 		5 LEU A 262
LEU A 288
ASP A 285
ILE A 380
GLY A 379
 None
 1.24A 6dm0B-5xhqA:
undetectable
6dm0C-5xhqA:
undetectable		 6dm0B-5xhqA:
10.62
6dm0C-5xhqA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 5 LEU A 753
LEU A1305
ASP A1304
ILE A 761
GLY A 762
 None
 0.98A 6dm0B-6bhuA:
undetectable
6dm0C-6bhuA:
undetectable		 6dm0B-6bhuA:
0.00
6dm0C-6bhuA:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bja ACETYL-COA
ACETYLTRANSFERASE A

(Ascaris suum) 		no annotation 5 SER A 184
ASP A 178
ILE A 331
SER A 324
GLY A 327
 None
 1.21A 6dm0B-6bjaA:
undetectable
6dm0C-6bjaA:
undetectable		 6dm0B-6bjaA:
21.25
6dm0C-6bjaA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnp UNCONVENTIONAL
MYOSIN-VI

(Sus scrofa) 		no annotation 5 LEU I 390
LEU I 601
ASP I 599
ILE I 350
GLY I 348
 None
 1.01A 6dm0B-6bnpI:
undetectable
6dm0C-6bnpI:
undetectable		 6dm0B-6bnpI:
19.10
6dm0C-6bnpI:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Acinetobacter
baumannii) 		no annotation 5 SER A 439
LEU A 329
ILE A 535
SER A 444
GLY A 465
 None
 1.22A 6dm0B-6d6kA:
undetectable
6dm0C-6d6kA:
undetectable		 6dm0B-6d6kA:
18.82
6dm0C-6d6kA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE SUBUNIT
BETA

(Trypanosoma
brucei) 		no annotation 5 LEU D 160
LEU D 334
ASP D 335
ILE D 172
SER D 311
 None
 1.25A 6dm0B-6f5dD:
2.4
6dm0C-6f5dD:
2.8		 6dm0B-6f5dD:
21.51
6dm0C-6f5dD:
21.51