SIMILAR PATTERNS OF AMINO ACIDS FOR 6DK1_B_GM4B301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dys ENDOGLUCANASE

(Humicola
insolens) 		PF01341
(Glyco_hydro_6) 		5 VAL A 130
ALA A 127
TYR A  51
LEU A  12
LEU A 124
 None
 1.29A 6dk1B-1dysA:
0.0		 6dk1B-1dysA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ivh ISOVALERYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 VAL A  80
ALA A 259
LEU A  13
ASP A   7
LEU A 256
 None
 1.44A 6dk1B-1ivhA:
0.0		 6dk1B-1ivhA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j33 COBT

(Thermus
thermophilus) 		PF02277
(DBI_PRT) 		5 VAL A 248
ALA A 308
LEU A  44
ALA A 311
LEU A 295
 None
 1.46A 6dk1B-1j33A:
0.0		 6dk1B-1j33A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhd SULFATE
ADENYLYLTRANSFERASE

(Sulfur-oxidizing
endosymbiont of
Riftia
pachyptila) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 VAL A  83
ALA A  64
LEU A 279
ALA A  67
LEU A  73
 None
 1.46A 6dk1B-1jhdA:
undetectable		 6dk1B-1jhdA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qni NITROUS-OXIDE
REDUCTASE

(Marinobacter
hydrocarbonoclasticus) 		no annotation 5 ALA A 379
TYR A 194
TYR A  90
ASP A 191
ALA A 387
 None
 1.27A 6dk1B-1qniA:
0.0		 6dk1B-1qniA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfz HYPOTHETICAL PROTEIN
APC35681

(Geobacillus
stearothermophilus) 		PF04608
(PgpA) 		5 VAL A  51
ALA A 153
LEU A  17
ALA A 150
LEU A  30
 None
 1.49A 6dk1B-1rfzA:
undetectable		 6dk1B-1rfzA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv TRANSFERRIN RECEPTOR
PROTEIN 1

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 VAL A 404
ALA A 451
TRP A 453
TYR A 470
LEU A 474
 None
 1.31A 6dk1B-1suvA:
0.0		 6dk1B-1suvA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaz ARCHAERHODOPSIN-1

(Halorubrum
chaoviator) 		PF01036
(Bac_rhodopsin) 		5 ALA A 166
TYR A  48
LEU A 229
ALA A 107
LEU A 162
 None
 1.41A 6dk1B-1uazA:
0.0		 6dk1B-1uazA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9i LOW TEMPERATURE
REQUIREMENT C
PROTEIN

(Listeria
monocytogenes) 		PF04608
(PgpA) 		5 VAL A  52
ALA A 154
LEU A  18
ALA A 151
LEU A  31
 None
 1.47A 6dk1B-1y9iA:
undetectable		 6dk1B-1y9iA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yua TOPOISOMERASE I

(Escherichia
coli) 		PF08272
(Topo_Zn_Ribbon) 		5 VAL A  86
ALA A  74
TRP A 117
ALA A  72
LEU A  57
 None
 1.47A 6dk1B-1yuaA:
0.0		 6dk1B-1yuaA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 VAL A 259
ALA A 332
TYR A  80
ALA A 329
LEU A 358
 None
 1.10A 6dk1B-2ebaA:
0.0		 6dk1B-2ebaA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1

(Crotalus atrox) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		5 VAL A 329
ALA A 332
ASP A 208
ALA A 301
LEU A 363
 None
 1.42A 6dk1B-2erqA:
undetectable		 6dk1B-2erqA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI

(Saccharopolyspora
erythraea) 		PF08659
(KR) 		5 ALA A1818
LEU A1764
ASP A1757
ALA A1591
LEU A1592
 None
 1.33A 6dk1B-2fr1A:
undetectable		 6dk1B-2fr1A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gko MICROBIAL SERINE
PROTEINASES
SUBTILISIN

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		5 VAL A 188
ALA A 251
LEU A 278
ALA A 228
LEU A 191
 None
 1.29A 6dk1B-2gkoA:
undetectable		 6dk1B-2gkoA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy9 SUBA

(Escherichia
coli) 		PF00082
(Peptidase_S8) 		5 VAL A 218
ALA A 274
LEU A 301
ALA A 251
LEU A 221
 None
 1.32A 6dk1B-2iy9A:
undetectable		 6dk1B-2iy9A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfc HYPOTHETICAL PROTEIN
RV0098/MT0107

(Mycobacterium
tuberculosis) 		PF10862
(FcoT) 		5 VAL A  53
ALA A  89
LEU A 145
TYR A 110
ALA A  93
 None
 1.46A 6dk1B-2pfcA:
undetectable		 6dk1B-2pfcA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5e PUTATIVE SERINE
PROTEASE

(Mamastrovirus 1) 		PF13365
(Trypsin_2) 		6 ALA A 503
TYR A 521
LEU A 526
TYR A 473
ALA A 436
LEU A 505
 None
 1.22A 6dk1B-2w5eA:
undetectable		 6dk1B-2w5eA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF13638
(PIN_4)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		5 VAL J 836
ALA J 691
LEU J 732
GLU J 729
ALA J 693
 None
 1.38A 6dk1B-2wp8J:
undetectable		 6dk1B-2wp8J:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z55 ARCHAERHODOPSIN-2

(Halobacterium
sp. AUS-2) 		PF01036
(Bac_rhodopsin) 		5 ALA A 165
TYR A  46
LEU A 228
ALA A 106
LEU A 161
 None
 1.36A 6dk1B-2z55A:
undetectable		 6dk1B-2z55A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)

(Thermus
thermophilus) 		PF14520
(HHH_5)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb) 		5 TYR A 192
LEU A 541
GLU A 540
ALA A 167
LEU A 199
 None
 1.38A 6dk1B-3auoA:
undetectable		 6dk1B-3auoA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bio OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Porphyromonas
gingivalis) 		PF01408
(GFO_IDH_MocA)
PF16654
(DAPDH_C) 		5 VAL A  68
ALA A  66
LEU A 102
ALA A  90
LEU A 263
 None
 1.40A 6dk1B-3bioA:
undetectable		 6dk1B-3bioA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d43 SPHERICASE

(Lysinibacillus
sphaericus) 		PF00082
(Peptidase_S8) 		5 VAL A 189
ALA A 252
LEU A 279
ALA A 229
LEU A 192
 None
 1.26A 6dk1B-3d43A:
undetectable		 6dk1B-3d43A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dde TENA/THI-4 PROTEIN,
DOMAIN OF UNKNOWN
FUNCTION WITH A HEME
OXYGENASE-LIKE FOLD

(Shewanella
denitrificans) 		PF14518
(Haem_oxygenas_2) 		5 VAL A 142
ALA A 139
TRP A 138
TYR A  43
TYR A  50
 None
 1.26A 6dk1B-3ddeA:
undetectable		 6dk1B-3ddeA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE

(Xylella
fastidiosa) 		PF07221
(GlcNAc_2-epim) 		5 ALA A 330
LEU A  18
ASP A  11
ALA A 327
LEU A 328
 None
 1.41A 6dk1B-3gt5A:
undetectable		 6dk1B-3gt5A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd8 XYLANASE INHIBITOR

(Triticum
aestivum) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		5 VAL A 234
LEU A 245
ASP A 248
ALA A 212
LEU A 306
 None
 1.39A 6dk1B-3hd8A:
undetectable		 6dk1B-3hd8A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0t DIPEPTIDYL PEPTIDASE
2

(Homo sapiens) 		PF05577
(Peptidase_S28) 		5 VAL A 189
ALA A 191
LEU A 404
ALA A 193
LEU A 395
 None
 1.45A 6dk1B-3n0tA:
undetectable		 6dk1B-3n0tA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nda SERPIN-2

(Ixodes ricinus) 		PF00079
(Serpin) 		5 ALA A  97
TRP A 141
ASP A  93
ALA A 120
LEU A 114
 None
 1.47A 6dk1B-3ndaA:
undetectable		 6dk1B-3ndaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqx SECRETED
METALLOPROTEASE
MCP02

(Pseudoalteromonas
sp. SM9913) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		5 ALA A 480
TYR A 434
LEU A 495
TRP A 447
ALA A 459
 None
 1.43A 6dk1B-3nqxA:
undetectable		 6dk1B-3nqxA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr4 DNA POLYMERASE IV

(Sulfolobus
solfataricus) 		PF00817
(IMS)
PF11798
(IMS_HHH) 		5 ALA A 154
TYR A 233
LEU A 228
TYR A 108
ALA A 151
 None
 1.42A 6dk1B-3pr4A:
undetectable		 6dk1B-3pr4A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqg 2-METHYLCITRATE
SYNTHASE

(Coxiella
burnetii) 		PF00285
(Citrate_synt) 		5 ALA A 274
TYR A 180
ASP A 264
ALA A 314
LEU A 318
 None
 1.32A 6dk1B-3tqgA:
undetectable		 6dk1B-3tqgA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyk NDP-RHAMNOSYLTRANSFE
RASE

(Saccharopolyspora
spinosa) 		PF06722
(DUF1205) 		5 ALA A  91
LEU A 139
ASP A 145
ALA A 155
LEU A 159
 None
 1.22A 6dk1B-3uykA:
undetectable		 6dk1B-3uykA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4el8 GLYCOSIDE HYDROLASE
FAMILY 48

(Caldicellulosiruptor
bescii) 		PF02011
(Glyco_hydro_48) 		5 ALA A 625
TRP A 241
GLU A 425
ALA A 623
LEU A 529
 None
 1.33A 6dk1B-4el8A:
undetectable		 6dk1B-4el8A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4x AMPHI

(Streptomyces
nodosus) 		PF08659
(KR) 		5 ALA A 302
LEU A 483
TRP A 274
ALA A 298
LEU A 325
 None
 1.28A 6dk1B-4l4xA:
undetectable		 6dk1B-4l4xA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkn TRIOSEPHOSPHATE
ISOMERASE

(Chlamydomonas
reinhardtii) 		PF00121
(TIM) 		5 VAL A  91
ALA A  80
GLU A 104
ALA A 116
LEU A 117
 None
 1.44A 6dk1B-4mknA:
undetectable		 6dk1B-4mknA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi4 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C) 		5 VAL A 313
LEU A 272
ASP A 297
ALA A 319
LEU A 419
 None
NAG  A 905 ( 4.4A)
None
None
None
 1.38A 6dk1B-4qi4A:
undetectable		 6dk1B-4qi4A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpc 10-FORMYLTETRAHYDROF
OLATE DEHYDROGENASE

(Danio rerio) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 ALA A 267
TRP A 213
TYR A 306
LEU A 293
ALA A 271
 None
 1.33A 6dk1B-4qpcA:
undetectable		 6dk1B-4qpcA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9v N-ALPHA-ACETYLTRANSF
ERASE 40

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		5 VAL B 140
ALA B 120
LEU B 190
TYR B  48
LEU B 109
 ACO  B 301 (-4.2A)
None
None
None
None
 1.04A 6dk1B-4u9vB:
undetectable		 6dk1B-4u9vB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yco TRNA-DIHYDROURIDINE
SYNTHASE C

(Escherichia
coli) 		PF01207
(Dus) 		5 VAL A 136
ALA A 162
TYR A 120
ALA A 123
LEU A  94
 None
 1.50A 6dk1B-4ycoA:
undetectable		 6dk1B-4ycoA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		5 ALA A 592
LEU A 715
TYR A   3
TRP A  16
ALA A 594
 None
 1.41A 6dk1B-5ah5A:
undetectable		 6dk1B-5ah5A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by7 3-OXOACYL-ACP
SYNTHASE III

(Verrucosispora
maris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 VAL A 162
ALA A  -6
LEU A  70
ASP A  76
ALA A  50
 None
 1.45A 6dk1B-5by7A:
undetectable		 6dk1B-5by7A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3m ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA1

(Lactobacillus
delbrueckii) 		PF00005
(ABC_tran) 		5 VAL A 213
ALA A  37
LEU A 237
ASP A 217
ALA A 207
 None
 1.13A 6dk1B-5d3mA:
undetectable		 6dk1B-5d3mA:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hk2 SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1

(Homo sapiens) 		PF04622
(ERG2_Sigma1R) 		11 VAL A  84
ALA A  86
TRP A  89
TYR A 103
LEU A 105
TYR A 120
ASP A 126
TRP A 164
GLU A 172
ALA A 185
LEU A 186
 61V  A 301 (-4.5A)
None
None
61V  A 301 ( 4.3A)
None
None
61V  A 301 (-3.2A)
None
61V  A 301 (-2.9A)
61V  A 301 ( 4.2A)
None
 0.54A 6dk1B-5hk2A:
33.6		 6dk1B-5hk2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lox PEPTIDASE

(Pseudomonas
aeruginosa) 		no annotation 5 VAL A  13
LEU A 159
TYR A   2
ALA A  15
LEU A 192
 None
 1.47A 6dk1B-5loxA:
undetectable		 6dk1B-5loxA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o16 AMBC

(Sorangium
cellulosum) 		no annotation 5 VAL A 259
ALA A 217
LEU A 270
TRP A 242
ALA A 220
 None
 1.40A 6dk1B-5o16A:
undetectable		 6dk1B-5o16A:
24.61