SIMILAR PATTERNS OF AMINO ACIDS FOR 6DJZ_C_GMJC301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bev BOVINE ENTEROVIRUS
COAT PROTEINS VP1 TO
VP4
BOVINE ENTEROVIRUS
COAT PROTEINS VP1 TO
VP4


(Enterovirus E;
Enterovirus E)
PF00073
(Rhv)
PF00073
(Rhv)
4 TRP 1 111
LEU 3  94
ASP 3 234
GLN 1 104
None
1.43A 6djzC-1bev1:
0.6
6djzC-1bev1:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7j PROTEIN
(PARA-NITROBENZYL
ESTERASE)


(Bacillus
subtilis)
PF00135
(COesterase)
4 LEU A 401
TYR A 118
GLN A 162
GLU A 188
None
1.31A 6djzC-1c7jA:
undetectable
6djzC-1c7jA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwa MYROSINASE MA1

(Sinapis alba)
PF00232
(Glyco_hydro_1)
4 TRP M 100
LEU M 232
TYR M 152
GLN M 146
None
None
None
GOL  M 933 (-3.4A)
1.31A 6djzC-1dwaM:
undetectable
6djzC-1dwaM:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT


(Methanopyrus
kandleri;
Methanopyrus
kandleri)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
4 LEU A 469
TYR B 191
ASP B 229
GLN B 221
None
1.32A 6djzC-1e6vA:
undetectable
6djzC-1e6vA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hmd HEMERYTHRIN

(Themiste
dyscritum)
no annotation 4 TRP A  97
LEU A  56
ASP A 106
GLU A  58
None
None
FEO  A 115 (-2.6A)
FEO  A 115 (-2.5A)
1.39A 6djzC-1hmdA:
undetectable
6djzC-1hmdA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0h NEOPULLULANASE

(Geobacillus
stearothermophilus)
PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C)
4 TRP A 160
LEU A 175
TYR A 457
GLN A 482
None
1.21A 6djzC-1j0hA:
3.0
6djzC-1j0hA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jf5 ALPHA AMYLASE II

(Thermoactinomyces
vulgaris)
PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C)
4 TRP A 156
LEU A 172
TYR A 454
GLN A 479
None
1.29A 6djzC-1jf5A:
2.3
6djzC-1jf5A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkr 3-METHYLASPARTATE
AMMONIA-LYASE


(Citrobacter
amalonaticus)
PF05034
(MAAL_N)
PF07476
(MAAL_C)
4 LEU A 245
TYR A  74
ASP A 238
GLN A 172
None
None
MG  A 501 ( 2.6A)
2AS  A 801 (-3.1A)
1.20A 6djzC-1kkrA:
0.9
6djzC-1kkrA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster)
PF00135
(COesterase)
4 LEU A 479
TYR A 162
GLN A 211
GLU A 237
None
None
None
I40  A 997 (-4.2A)
1.42A 6djzC-1qonA:
undetectable
6djzC-1qonA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC


(Escherichia
coli)
PF03009
(GDPD)
4 LEU A 215
TYR A 313
ASP A  65
GLU A 171
None
GOL  A1605 (-3.8A)
MG  A1601 ( 2.7A)
MG  A1601 ( 2.9A)
1.06A 6djzC-1t8qA:
undetectable
6djzC-1t8qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1


(Thermus
thermophilus)
PF02347
(GDC-P)
4 LEU A 214
TYR A 163
ASP A 233
GLN A 256
None
1.49A 6djzC-1wytA:
undetectable
6djzC-1wytA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddx BETA-1,3-XYLANASE

(Vibrio sp. AX-4)
no annotation 4 LEU A 297
TYR A 267
ASP A 289
GLN A 275
None
1.47A 6djzC-2ddxA:
undetectable
6djzC-2ddxA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3z BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium)
PF00232
(Glyco_hydro_1)
4 TRP A  82
LEU A 203
TYR A 134
GLN A 128
None
1.25A 6djzC-2e3zA:
undetectable
6djzC-2e3zA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum)
PF14498
(Glyco_hyd_65N_2)
4 LEU A 534
TYR A 520
ASP A 689
GLN A 781
None
None
CA  A 902 (-2.9A)
None
1.49A 6djzC-2eaeA:
undetectable
6djzC-2eaeA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum)
PF14498
(Glyco_hyd_65N_2)
4 LEU A 779
TYR A 520
GLN A 512
GLU A 777
None
1.44A 6djzC-2eaeA:
undetectable
6djzC-2eaeA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyx PROTEIN DIPZ

(Mycobacterium
tuberculosis)
PF00578
(AhpC-TSA)
4 TRP A 508
TYR A 469
GLN A 441
GLU A 570
None
1.31A 6djzC-2hyxA:
2.6
6djzC-2hyxA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iss GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT


(Thermotoga
maritima)
PF01174
(SNO)
4 LEU D 179
ASP D  11
GLN D   9
GLU D 172
None
1.34A 6djzC-2issD:
undetectable
6djzC-2issD:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lpu KMATG10

(Kluyveromyces
marxianus)
PF03987
(Autophagy_act_C)
4 LEU A  17
TYR A   7
ASP A  29
GLN A  31
None
1.29A 6djzC-2lpuA:
undetectable
6djzC-2lpuA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otd GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE


(Shigella
flexneri)
PF03009
(GDPD)
4 LEU A 153
TYR A 213
ASP A  41
GLU A 114
None
PO4  A 301 (-4.0A)
PO4  A 301 (-3.8A)
PO4  A 301 (-3.4A)
0.95A 6djzC-2otdA:
undetectable
6djzC-2otdA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oz8 MLL7089 PROTEIN

(Mesorhizobium
japonicum)
PF13378
(MR_MLE_C)
4 LEU A 268
TYR A 134
ASP A 194
GLU A 222
None
1.48A 6djzC-2oz8A:
undetectable
6djzC-2oz8A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST


(Vitis vinifera)
PF00264
(Tyrosinase)
PF12142
(PPO1_DWL)
4 LEU A 131
TYR A 122
GLN A  37
GLU A 308
None
1.34A 6djzC-2p3xA:
undetectable
6djzC-2p3xA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p76 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE


(Staphylococcus
aureus)
PF03009
(GDPD)
4 LEU A 213
TYR A 277
ASP A  89
GLU A 169
None
GOL  A 501 ( 4.2A)
NA  A 401 (-2.6A)
NA  A 401 ( 3.0A)
1.13A 6djzC-2p76A:
undetectable
6djzC-2p76A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjj MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME


(Novosphingobium
aromaticivorans)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 TRP A 402
LEU A 317
ASP A 237
GLU A 262
None
None
MG  A1001 ( 4.6A)
MG  A1001 (-2.5A)
1.45A 6djzC-2qjjA:
undetectable
6djzC-2qjjA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qry THIAMINE-BINDING
PERIPLASMIC PROTEIN


(Escherichia
coli)
PF13343
(SBP_bac_6)
4 LEU A  86
TYR A 215
ASP A 121
GLU A 245
None
TPS  A 400 (-4.3A)
None
TPS  A 400 (-3.3A)
1.45A 6djzC-2qryA:
undetectable
6djzC-2qryA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vx4 CELLVIBRIO JAPONICUS
MANNANASE CJMAN26C


(Cellvibrio
japonicus)
PF02156
(Glyco_hydro_26)
4 LEU A 186
TYR A 261
ASP A 252
GLN A  60
None
1.47A 6djzC-2vx4A:
undetectable
6djzC-2vx4A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiv BETA-GLUCOSIDASE

(Secale cereale)
PF00232
(Glyco_hydro_1)
4 TRP A 106
LEU A 236
TYR A 156
GLN A 150
None
1.28A 6djzC-3aivA:
undetectable
6djzC-3aivA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens)
PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N)
4 LEU A  87
TYR A 263
GLN A 117
GLU A  90
None
1.25A 6djzC-3cttA:
1.3
6djzC-3cttA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqa GLUCOAMYLASE

(Aspergillus
niger)
PF00723
(Glyco_hydro_15)
4 LEU A 446
ASP A 354
GLN A 292
GLU A 350
None
1.47A 6djzC-3eqaA:
undetectable
6djzC-3eqaA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN


([Eubacterium]
rectale)
PF13614
(AAA_31)
4 LEU A 290
TYR A 225
GLN A 163
GLU A 253
None
1.50A 6djzC-3fkqA:
undetectable
6djzC-3fkqA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxg RHAMNONATE
DEHYDRATASE


(Fusarium
graminearum)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 LEU A 291
TYR A 166
ASP A 221
GLU A 247
None
None
MG  A 501 (-2.8A)
MG  A 501 (-3.2A)
1.49A 6djzC-3fxgA:
undetectable
6djzC-3fxgA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gkb PUTATIVE ENOYL-COA
HYDRATASE


(Streptomyces
avermitilis)
PF00378
(ECH_1)
4 TRP A 186
LEU A 268
GLN A 155
GLU A 142
None
1.38A 6djzC-3gkbA:
undetectable
6djzC-3gkbA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gku PROBABLE RNA-BINDING
PROTEIN


([Clostridium]
symbiosum)
PF01424
(R3H)
PF13083
(KH_4)
PF14804
(Jag_N)
4 LEU A 167
TYR A 139
GLN A 115
GLU A 174
None
1.39A 6djzC-3gkuA:
undetectable
6djzC-3gkuA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnr OS03G0212800 PROTEIN

(Oryza sativa)
PF00232
(Glyco_hydro_1)
4 TRP A  93
LEU A 223
TYR A 143
GLN A 137
TRP  A  93 ( 0.5A)
LEU  A 223 ( 0.5A)
TYR  A 143 ( 1.3A)
GLN  A 137 ( 0.6A)
1.39A 6djzC-3gnrA:
undetectable
6djzC-3gnrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4y CATECHOL
1,2-DIOXYGENASE


(Rhodococcus
opacus)
PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N)
4 TRP A 154
LEU A  91
ASP A  80
GLU A  84
None
1.31A 6djzC-3i4yA:
undetectable
6djzC-3i4yA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr1 PUTATIVE
FRUCTOSAMINE-3-KINAS
E


(Histophilus
somni)
PF03881
(Fructosamin_kin)
4 LEU A 251
TYR A 240
ASP A 218
GLU A 220
None
1.36A 6djzC-3jr1A:
undetectable
6djzC-3jr1A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC


(Escherichia
coli)
no annotation 4 LEU A 455
TYR A 374
ASP A 225
GLN A 303
None
1.08A 6djzC-3ly9A:
undetectable
6djzC-3ly9A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzn GLUCARATE
DEHYDRATASE


(Chromohalobacter
salexigens)
PF13378
(MR_MLE_C)
4 TRP A 170
LEU A 149
ASP A  17
GLN A 371
None
1.45A 6djzC-3mznA:
undetectable
6djzC-3mznA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3t PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE


(Thiobacillus
denitrificans)
PF00563
(EAL)
4 LEU A 613
ASP A 646
GLN A 670
GLU A 616
None
MG  A 802 (-2.7A)
C2E  A 801 (-3.3A)
MG  A 802 (-3.2A)
1.37A 6djzC-3n3tA:
undetectable
6djzC-3n3tA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ptk BETA-GLUCOSIDASE
OS4BGLU12


(Oryza sativa)
PF00232
(Glyco_hydro_1)
4 TRP A  92
LEU A 224
TYR A 144
GLN A 138
None
1.32A 6djzC-3ptkA:
undetectable
6djzC-3ptkA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsv MOTHERS AGAINST
DECAPENTAPLEGIC
HOMOLOG 4


(Mus musculus)
PF03165
(MH1)
4 LEU A  43
TYR A 117
ASP A  52
GLU A  53
None
1.24A 6djzC-3qsvA:
undetectable
6djzC-3qsvA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxf ENDOGLUCANASE

(Escherichia
coli)
PF01270
(Glyco_hydro_8)
4 TRP A 221
LEU A  97
ASP A 116
GLU A  55
None
1.19A 6djzC-3qxfA:
undetectable
6djzC-3qxfA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thu MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN


(Sphingomonas
sp. SKA58)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 TRP A 403
LEU A 318
ASP A 238
GLU A 263
None
None
MG  A 500 ( 4.5A)
MG  A 500 ( 2.6A)
1.48A 6djzC-3thuA:
undetectable
6djzC-3thuA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE


(Rauvolfia
serpentina)
PF00232
(Glyco_hydro_1)
4 TRP A  99
LEU A 248
TYR A 151
GLN A 145
None
1.28A 6djzC-3u5uA:
undetectable
6djzC-3u5uA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ucq AMYLOSUCRASE

(Deinococcus
geothermalis)
PF00128
(Alpha-amylase)
4 LEU A 334
ASP A 284
GLN A 252
GLU A 326
None
GOL  A 720 (-3.0A)
GOL  A 720 ( 4.4A)
TRS  A 700 (-4.2A)
1.34A 6djzC-3ucqA:
3.0
6djzC-3ucqA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4b STARVATION SENSING
PROTEIN RSPA


(Cellvibrio
japonicus)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 TRP A 402
LEU A 317
ASP A 237
GLU A 262
None
None
MG  A 403 ( 4.6A)
MG  A 403 ( 2.5A)
1.46A 6djzC-3v4bA:
undetectable
6djzC-3v4bA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcn MANNONATE
DEHYDRATASE


(Caulobacter
vibrioides)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 TRP A 403
LEU A 318
ASP A 238
GLU A 263
None
None
MG  A 501 ( 4.6A)
MG  A 501 (-2.5A)
1.50A 6djzC-3vcnA:
undetectable
6djzC-3vcnA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wau 4-O-BETA-D-MANNOSYL-
D-GLUCOSE
PHOSPHORYLASE


(Bacteroides
fragilis)
PF04041
(Glyco_hydro_130)
4 TRP A 225
LEU A 269
GLN A 190
GLU A 257
None
1.25A 6djzC-3wauA:
undetectable
6djzC-3wauA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1


(Homo sapiens)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 LEU A 326
TYR A 194
ASP A 254
GLU A 280
None
None
MG  A1445 (-2.6A)
MG  A1445 (-3.0A)
1.48A 6djzC-4a35A:
undetectable
6djzC-4a35A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B


(Cellvibrio
japonicus)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110)
4 LEU A 300
TYR A 189
ASP A 509
GLN A 491
None
1.39A 6djzC-4b9yA:
undetectable
6djzC-4b9yA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bla MALTOSE-BINDING
PERIPLASMIC PROTEIN,
SUPPRESSOR OF FUSED
HOMOLOG


(Escherichia
coli;
Homo sapiens)
PF05076
(SUFU)
PF12470
(SUFU_C)
PF13416
(SBP_bac_8)
4 LEU A 464
TYR A 385
ASP A 522
GLN A 526
None
1.41A 6djzC-4blaA:
undetectable
6djzC-4blaA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1


(Homo sapiens)
PF03372
(Exo_endo_phos)
4 LEU A 376
TYR A 513
ASP A 451
GLN A 445
None
1.50A 6djzC-4cmnA:
undetectable
6djzC-4cmnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csq UNCHARACTERIZED
PROTEIN


(Pseudomonas
aeruginosa)
no annotation 4 LEU A 103
ASP A  12
GLN A   7
GLU A  13
None
1.44A 6djzC-4csqA:
undetectable
6djzC-4csqA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4f MANNONATE
DEHYDRATASE


(Pectobacterium
carotovorum)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 TRP A 404
LEU A 319
ASP A 239
GLU A 264
None
None
MG  A 504 (-4.0A)
MG  A 504 ( 2.5A)
1.49A 6djzC-4e4fA:
undetectable
6djzC-4e4fA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE


(Homo sapiens)
PF00884
(Sulfatase)
PF14707
(Sulfatase_C)
4 TRP A 141
LEU A 128
GLN A 148
GLU A 126
None
1.41A 6djzC-4fdjA:
undetectable
6djzC-4fdjA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fi4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Caulobacter sp.
K31)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 TRP A 403
LEU A 318
ASP A 238
GLU A 263
None
None
MG  A 501 ( 4.5A)
MG  A 501 ( 2.5A)
1.49A 6djzC-4fi4A:
undetectable
6djzC-4fi4A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN


(Pseudomonas)
PF01804
(Penicil_amidase)
4 TRP A 149
LEU A 161
TYR A 121
GLN A  62
None
1.47A 6djzC-4hstA:
undetectable
6djzC-4hstA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyq PHOSPHOLIPASE A1

(Streptomyces
albidoflavus)
PF13472
(Lipase_GDSL_2)
4 LEU A 205
TYR A  35
ASP A  10
GLN A  65
None
1.50A 6djzC-4hyqA:
undetectable
6djzC-4hyqA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ip4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN


(Ruegeria sp.
TM1040)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 LEU A 316
TYR A 186
ASP A 246
GLU A 272
None
None
MG  A 503 (-2.6A)
MG  A 503 (-2.9A)
1.40A 6djzC-4ip4A:
undetectable
6djzC-4ip4A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
PF00105
(zf-C4)
4 LEU A 329
TYR A 319
ASP A 273
GLU A 276
None
1.24A 6djzC-4iqrA:
undetectable
6djzC-4iqrA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j91 KTR SYSTEM POTASSIUM
UPTAKE PROTEIN A


(Bacillus
subtilis)
PF02080
(TrkA_C)
PF02254
(TrkA_N)
4 LEU A 162
ASP A 138
GLN A 134
GLU A 218
None
1.13A 6djzC-4j91A:
undetectable
6djzC-4j91A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc2 ASFP504

(Alcyonium)
PF01353
(GFP)
4 LEU A 219
TYR A  71
ASP A  74
GLN A 184
None
1.34A 6djzC-4jc2A:
undetectable
6djzC-4jc2A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kws D-MANNONATE
DEHYDRATASE


(Chromohalobacter
salexigens)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 TRP A 405
LEU A 320
ASP A 240
GLU A 265
None
None
MG  A 501 ( 4.7A)
MG  A 501 ( 2.5A)
1.48A 6djzC-4kwsA:
undetectable
6djzC-4kwsA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kws D-MANNONATE
DEHYDRATASE


(Chromohalobacter
salexigens)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 TRP A 405
LEU A 320
TYR A 171
ASP A 213
None
None
None
MG  A 501 (-2.6A)
1.43A 6djzC-4kwsA:
undetectable
6djzC-4kwsA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7z HPCH/HPAI ALDOLASE

(Chloroflexus
aurantiacus)
PF03328
(HpcH_HpaI)
4 TRP A 272
LEU A  96
ASP A  61
GLU A  60
None
1.49A 6djzC-4l7zA:
undetectable
6djzC-4l7zA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
RAS-RELATED PROTEIN
RAP-1B


(Mus musculus;
Homo sapiens)
PF00027
(cNMP_binding)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00071
(Ras)
4 LEU E 893
ASP R  38
GLN R  43
GLU R  37
None
1.25A 6djzC-4mh0E:
1.6
6djzC-4mh0E:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nex ACETYLGLUTAMATE
KINASE


(Xylella
fastidiosa)
PF04768
(NAT)
4 TRP A 409
LEU A 319
TYR A 352
GLN A 431
None
0.93A 6djzC-4nexA:
undetectable
6djzC-4nexA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzr PROTEIN M TD

(Mycoplasma
genitalium)
no annotation 4 LEU M 169
TYR M 293
ASP M 339
GLU M 313
None
GOL  M 501 ( 2.8A)
None
None
1.42A 6djzC-4nzrM:
undetectable
6djzC-4nzrM:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Actinobacillus
succinogenes)
PF03480
(DctP)
4 LEU A  95
TYR A 147
GLN A  36
GLU A  73
None
2Q2  A 403 (-4.1A)
None
2Q2  A 403 (-2.8A)
1.50A 6djzC-4o8mA:
undetectable
6djzC-4o8mA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovj EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1


(Alicyclobacillus
acidocaldarius)
PF13416
(SBP_bac_8)
4 LEU A 298
ASP A 205
GLN A 415
GLU A 280
None
1.27A 6djzC-4ovjA:
undetectable
6djzC-4ovjA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE


(Bacillus
anthracis)
PF03009
(GDPD)
4 LEU A 195
TYR A 280
ASP A  72
GLU A 152
None
GOL  A 405 (-3.6A)
MG  A 401 (-3.0A)
MG  A 401 ( 3.1A)
1.16A 6djzC-4r7oA:
undetectable
6djzC-4r7oA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)


(Clostridium
acetobutylicum)
PF07470
(Glyco_hydro_88)
4 TRP A 204
LEU A  19
GLN A 250
GLU A 344
None
1.49A 6djzC-4wu0A:
undetectable
6djzC-4wu0A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmv AMINOPEPTIDASE N

(Escherichia
coli)
PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C)
4 LEU A 731
TYR A 660
ASP A 712
GLN A 665
None
None
GOL  A 913 (-3.4A)
None
1.44A 6djzC-4xmvA:
undetectable
6djzC-4xmvA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwt DR2417

(Deinococcus
radiodurans)
PF00753
(Lactamase_B)
PF07521
(RMMBL)
4 LEU A  93
TYR A 276
GLN A 316
GLU A  87
None
1.46A 6djzC-4xwtA:
undetectable
6djzC-4xwtA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ygs HYDROLASE

(Thermococcus
onnurineus)
PF13419
(HAD_2)
4 LEU A  23
TYR A 114
ASP A   9
GLU A  15
None
1.42A 6djzC-4ygsA:
undetectable
6djzC-4ygsA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0z AURONE SYNTHASE

(Coreopsis
grandiflora)
PF00264
(Tyrosinase)
PF12142
(PPO1_DWL)
4 LEU A 139
TYR A 130
GLN A  44
GLU A 322
None
1.46A 6djzC-4z0zA:
undetectable
6djzC-4z0zA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE


(Geobacillus
stearothermophilus)
PF00232
(Glyco_hydro_1)
4 TRP A  85
LEU A 203
TYR A 135
GLN A 129
None
1.29A 6djzC-4zfmA:
undetectable
6djzC-4zfmA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgv FERREDOXIN RECEPTOR

(Pectobacterium
atrosepticum)
PF07715
(Plug)
4 LEU A 600
TYR A 459
GLN A 478
GLU A 586
None
1.26A 6djzC-4zgvA:
undetectable
6djzC-4zgvA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA


(Methanothermobacter
marburgensis;
Methanothermobacter
marburgensis)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
4 LEU A 468
TYR B 190
ASP B 228
GLN B 220
None
1.41A 6djzC-5a8rA:
undetectable
6djzC-5a8rA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd6 TPR-DOMAIN
CONTAINING PROTEIN


(Parabacteroides
distasonis)
PF17128
(DUF5107)
4 LEU A 488
TYR A 428
ASP A 399
GLU A 398
None
1.41A 6djzC-5cd6A:
1.0
6djzC-5cd6A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE


(Bacillus
subtilis)
PF00698
(Acyl_transf_1)
4 LEU A 234
TYR A  62
ASP A 101
GLN A  30
None
1.45A 6djzC-5dz7A:
undetectable
6djzC-5dz7A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE


(Rhodobacter
sphaeroides)
PF00535
(Glycos_transf_2)
PF03552
(Cellulose_synt)
PF07238
(PilZ)
4 LEU A 205
ASP A 248
GLN A 379
GLU A 151
None
1.38A 6djzC-5ej1A:
undetectable
6djzC-5ej1A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fpw PRO CATHEPSIN B S9

(Trypanosoma
congolense)
PF00112
(Peptidase_C1)
4 TRP A  27
LEU A 256
ASP A 252
GLN A  21
None
1.48A 6djzC-5fpwA:
undetectable
6djzC-5fpwA:
18.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hk2 SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1


(Homo sapiens)
PF04622
(ERG2_Sigma1R)
6 TRP A  89
LEU A  95
TYR A 120
ASP A 126
GLN A 135
GLU A 172
None
None
None
61V  A 301 (-3.2A)
None
61V  A 301 (-2.9A)
0.34A 6djzC-5hk2A:
34.1
6djzC-5hk2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5in8 ARISTOLOCHENE
SYNTHASE


(Aspergillus
terreus)
no annotation 4 LEU A 178
TYR A 168
ASP A 214
GLN A 240
None
1.45A 6djzC-5in8A:
0.6
6djzC-5in8A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j98 VP3

(Slow bee
paralysis virus)
PF00073
(Rhv)
4 LEU C 367
TYR C 110
ASP C 416
GLU C 372
None
1.33A 6djzC-5j98C:
undetectable
6djzC-5j98C:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK


(Streptomyces
peucetius)
PF00891
(Methyltransf_2)
4 LEU A 302
TYR A 342
ASP A 287
GLN A 334
None
4MU  A 402 ( 4.6A)
None
None
1.38A 6djzC-5jr3A:
undetectable
6djzC-5jr3A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 UNCHARACTERIZED
PROTEIN
N-TERMINAL
ACETYLTRANSFERASE B
COMPLEX SUBUNIT NAT3


(Candida
albicans;
Candida
albicans)
PF09797
(NatB_MDM20)
PF08445
(FR47)
4 LEU B 123
TYR B  57
ASP B  21
GLN A 436
COA  B 202 (-2.9A)
None
COA  B 202 ( 4.0A)
None
1.34A 6djzC-5k04B:
undetectable
6djzC-5k04B:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkg DIGUANYLATE
PHOSPHODIESTERASE


(Pseudomonas
aeruginosa)
PF00563
(EAL)
4 LEU B 127
ASP B 160
GLN B 184
GLU B 130
None
CA  B 302 (-2.5A)
C2E  B 304 (-3.1A)
CA  B 302 (-3.3A)
1.38A 6djzC-5mkgB:
undetectable
6djzC-5mkgB:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)


(Plasmodium
falciparum)
PF05424
(Duffy_binding)
4 LEU A 932
ASP A 922
GLN A 822
GLU A 925
None
1.26A 6djzC-5mzaA:
undetectable
6djzC-5mzaA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogs WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1


(Homo sapiens)
no annotation 4 LEU A 440
ASP A 534
GLN A 531
GLU A 502
None
1.49A 6djzC-5ogsA:
undetectable
6djzC-5ogsA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt 40S RIBOSOMAL
PROTEIN S12
40S RIBOSOMAL
PROTEIN S10,
PUTATIVE


(Trypanosoma
cruzi;
Trypanosoma
cruzi)
no annotation
no annotation
4 LEU i  43
TYR n  86
ASP n  11
GLN n  48
None
None
U  E1725 ( 3.6A)
None
1.40A 6djzC-5opti:
undetectable
6djzC-5opti:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqp CONDENSIN COMPLEX
SUBUNIT 3


(Saccharomyces
cerevisiae)
no annotation 4 LEU A 724
ASP A 771
GLN A 841
GLU A 726
None
1.43A 6djzC-5oqpA:
undetectable
6djzC-5oqpA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN


(Chaetomium
thermophilum)
PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C)
4 LEU A 501
ASP A 583
GLN A 447
GLU A 508
None
1.44A 6djzC-5t8vA:
undetectable
6djzC-5t8vA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9c GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE


(Bacillus
subtilis)
PF03009
(GDPD)
4 LEU E 195
TYR E 259
ASP E  72
GLU E 152
None
G3P  E 302 (-3.8A)
CA  E 301 ( 2.9A)
CA  E 301 ( 3.2A)
1.13A 6djzC-5t9cE:
undetectable
6djzC-5t9cE:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s DNA REPLICATION
LICENSING FACTOR
MCM4


(Saccharomyces
cerevisiae)
PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB)
4 LEU 4 544
TYR 4 706
ASP 4 703
GLN 4 797
None
1.18A 6djzC-5u8s4:
undetectable
6djzC-5u8s4:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1


(Saccharomyces
cerevisiae)
no annotation 4 TRP C1158
TYR C1297
GLN C1151
GLU C1140
None
1.48A 6djzC-5x6oC:
undetectable
6djzC-5x6oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4k DMSP LYASE DDDY

(Acinetobacter
bereziniae)
no annotation 4 TRP A 315
LEU A 355
TYR A 262
GLN A 294
None
1.41A 6djzC-5y4kA:
4.8
6djzC-5y4kA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdf TRNA
(CYTOSINE(38)-C(5))-
METHYLTRANSFERASE


(Schizosaccharomyces
pombe)
no annotation 4 TRP A 294
LEU A 285
TYR A 211
GLU A 203
None
1.27A 6djzC-6fdfA:
undetectable
6djzC-6fdfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frv GLUCOAMYLASE

(Aspergillus
niger)
no annotation 4 LEU A 446
ASP A 354
GLN A 292
GLU A 350
None
1.48A 6djzC-6frvA:
undetectable
6djzC-6frvA:
undetectable