SIMILAR PATTERNS OF AMINO ACIDS FOR 6DJZ_C_GMJC301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjw ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		5 ALA A 235
PHE A 354
VAL A 126
VAL A 349
ALA A 365
 LLP  A 234 ( 3.7A)
None
None
None
None
 1.05A 6djzC-1bjwA:
0.0		 6djzC-1bjwA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3r HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN)

(Aquifex
aeolicus) 		PF00850
(Hist_deacetyl) 		5 ALA A 169
LEU A 167
PHE A 286
LEU A 222
ALA A 234
 ZN  A 501 ( 4.9A)
None
None
None
None
 1.11A 6djzC-1c3rA:
0.0		 6djzC-1c3rA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 MET A 342
SER A 379
VAL A 384
LEU A 298
ALA A 349
 None
 1.11A 6djzC-1g8xA:
0.0		 6djzC-1g8xA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg0 L-ASPARAGINASE

(Dickeya
chrysanthemi) 		PF00710
(Asparaginase) 		5 ALA A  42
PHE A 177
VAL A 154
HIS A  93
LEU A  34
 None
 1.05A 6djzC-1hg0A:
0.0		 6djzC-1hg0A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 ALA A 458
LEU A   8
VAL A  13
LEU A 177
ALA A  58
 None
 1.11A 6djzC-1i7qA:
0.0		 6djzC-1i7qA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqb NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Clostridium
beijerinckii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 MET A1140
ALA A1134
LEU A1136
VAL A1323
THR A1149
 None
 1.15A 6djzC-1jqbA:
0.0		 6djzC-1jqbA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 MET A 353
SER A 390
VAL A 395
LEU A 309
ALA A 360
 None
 1.16A 6djzC-1jx2A:
0.9		 6djzC-1jx2A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7j D-AMINOACYLASE

(Alcaligenes
faecalis) 		PF07969
(Amidohydro_3) 		6 SER A 249
PHE A 413
VAL A  92
HIS A  67
VAL A 247
TYR A 389
 None
None
None
ZN  A 802 ( 3.2A)
None
None
 1.10A 6djzC-1m7jA:
undetectable		 6djzC-1m7jA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		5 ALA A  59
LEU A  57
VAL A 239
LEU A  92
ALA A  98
 None
 0.99A 6djzC-1p88A:
0.0		 6djzC-1p88A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE

(Mycobacterium
tuberculosis) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 LEU A  45
VAL A 278
THR A  62
ALA A 103
TYR A  72
 None
 1.17A 6djzC-1qpoA:
undetectable		 6djzC-1qpoA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Pseudomonas
putida) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 SER A 246
HIS A 176
VAL A 169
LEU A 333
ALA A 294
 None
 1.04A 6djzC-1re5A:
undetectable		 6djzC-1re5A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14

(Mus musculus) 		no annotation 5 ALA A  80
LEU A  40
PHE A  30
LEU A  87
ALA A  90
 None
 1.07A 6djzC-1wwlA:
undetectable		 6djzC-1wwlA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2

(Archaeoglobus
fulgidus) 		PF02552
(CO_dh) 		5 LEU A  88
PHE A  74
VAL A  83
VAL A  54
LEU A 126
 None
 1.13A 6djzC-1ytlA:
undetectable		 6djzC-1ytlA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2coc FYVE, RHOGEF AND PH
DOMAIN CONTAINING
PROTEIN 3

(Homo sapiens) 		no annotation 5 ALA A  28
SER A 111
THR A 100
LEU A 101
ALA A 104
 None
 1.11A 6djzC-2cocA:
undetectable		 6djzC-2cocA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A  67
VAL A 179
THR A  79
LEU A 272
ALA A 216
 None
 1.06A 6djzC-2ctzA:
undetectable		 6djzC-2ctzA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ALA A 222
LEU A  51
VAL A  36
THR A  41
ALA A 290
 None
 1.15A 6djzC-2cu0A:
undetectable		 6djzC-2cu0A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE

(Thermus
thermophilus) 		PF00596
(Aldolase_II) 		5 ALA A 161
LEU A   5
VAL A  57
HIS A  74
LEU A 167
 None
 1.15A 6djzC-2fk5A:
undetectable		 6djzC-2fk5A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jk0 L-ASPARAGINASE

(Pectobacterium
carotovorum) 		PF00710
(Asparaginase) 		5 ALA A  42
PHE A 177
VAL A 154
HIS A  93
LEU A  34
 None
 1.04A 6djzC-2jk0A:
undetectable		 6djzC-2jk0A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nc8 LIPOPROTEIN LPPM

(Mycobacterium
tuberculosis) 		no annotation 5 ALA A 125
LEU A 110
PHE A  66
VAL A  70
ALA A  30
 None
 1.17A 6djzC-2nc8A:
undetectable		 6djzC-2nc8A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00275
(EPSP_synthase) 		5 MET A 386
ALA A 346
VAL A 397
LEU A 366
ALA A 317
 None
 1.15A 6djzC-2o0xA:
undetectable		 6djzC-2o0xA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6t DNAB REPLICATION
FORK HELICASE

(Thermus
aquaticus) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		5 LEU A 359
VAL A 415
THR A 219
LEU A 218
ALA A 221
 None
 1.17A 6djzC-2q6tA:
undetectable		 6djzC-2q6tA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlt (DL)-GLYCEROL-3-PHOS
PHATASE 1

(Saccharomyces
cerevisiae) 		PF13419
(HAD_2) 		5 ALA A 126
LEU A 124
SER A 241
VAL A 114
VAL A 236
 None
 1.03A 6djzC-2qltA:
undetectable		 6djzC-2qltA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyg RIBULOSE
BISPHOSPHATE
CARBOXYLASE-LIKE
PROTEIN 2

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 ALA A 314
LEU A 310
PHE A  26
HIS A 100
VAL A 121
 None
 1.17A 6djzC-2qygA:
undetectable		 6djzC-2qygA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ral SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN G

(Staphylococcus
epidermidis) 		PF10425
(SdrG_C_C) 		5 LEU A 497
PHE A 530
VAL A 488
VAL A 467
TYR A 424
 None
 1.09A 6djzC-2ralA:
2.3		 6djzC-2ralA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgw ASPARTATE
CARBAMOYLTRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ALA A 294
LEU A 299
VAL A  46
THR A 133
LEU A 136
 None
 1.16A 6djzC-2rgwA:
undetectable		 6djzC-2rgwA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Staphylococcus
haemolyticus) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 ALA B 693
LEU B 689
PHE B 622
LEU B 638
ALA B 633
 None
 1.08A 6djzC-2rhqB:
undetectable		 6djzC-2rhqB:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vcy TRANS-2-ENOYL-COA
REDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A 206
LEU A 340
VAL A 152
LEU A 175
ALA A 171
 None
 1.07A 6djzC-2vcyA:
undetectable		 6djzC-2vcyA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei) 		PF00686
(CBM_20)
PF00723
(Glyco_hydro_15) 		5 ALA A 195
PHE A 470
VAL A 154
LEU A 130
ALA A  56
 None
 1.13A 6djzC-2vn7A:
undetectable		 6djzC-2vn7A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vro ALDEHYDE
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF00171
(Aldedh) 		5 ALA A 381
LEU A 320
PHE A 280
VAL A 304
ALA A 361
 None
 0.99A 6djzC-2vroA:
undetectable		 6djzC-2vroA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vro ALDEHYDE
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF00171
(Aldedh) 		5 ALA A 381
LEU A 320
PHE A 280
VAL A 304
LEU A 360
 None
 1.15A 6djzC-2vroA:
undetectable		 6djzC-2vroA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1c ACYL-COENZYME

(Penicillium
chrysogenum) 		PF03417
(AAT) 		5 ALA A 211
LEU A 224
LEU A 185
ALA A 188
TYR A 166
 None
 1.11A 6djzC-2x1cA:
undetectable		 6djzC-2x1cA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 ALA A 237
VAL A 633
LEU A 322
ALA A 336
TYR A 264
 None
 1.16A 6djzC-2ycbA:
undetectable		 6djzC-2ycbA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3) 		5 ALA A 754
PHE A 589
THR A 766
LEU A 767
ALA A 770
 None
None
5PL  A 900 (-2.8A)
None
5PL  A 900 ( 4.3A)
 1.00A 6djzC-2yevA:
undetectable		 6djzC-2yevA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a77 INTERFERON
REGULATORY FACTOR 3

(Homo sapiens) 		PF10401
(IRF-3) 		5 ALA A 283
LEU A 281
SER A 396
VAL A 197
LEU A 226
 None
 1.06A 6djzC-3a77A:
undetectable		 6djzC-3a77A:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp. A1) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		6 ALA B  91
LEU B 101
PHE B  52
HIS B 201
THR B  78
LEU B  85
 None
 1.50A 6djzC-3amjB:
undetectable		 6djzC-3amjB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnj CHOLESTEROL OXIDASE

(Streptomyces
sp. SA-COO) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ALA A 441
VAL A 482
VAL A 124
LEU A 375
ALA A 363
 None
 1.09A 6djzC-3cnjA:
undetectable		 6djzC-3cnjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpx AMINOPEPTIDASE, M42
FAMILY

(Cytophaga
hutchinsonii) 		PF05343
(Peptidase_M42) 		5 ALA A 180
LEU A 257
THR A 169
ALA A 167
TYR A 181
 EDO  A 406 (-3.5A)
None
None
None
None
 1.13A 6djzC-3cpxA:
undetectable		 6djzC-3cpxA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddm PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 374
VAL A  45
VAL A  73
LEU A 344
ALA A  40
 None
 1.11A 6djzC-3ddmA:
undetectable		 6djzC-3ddmA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfr DIHYDROFOLATE
REDUCTASE

(Lactobacillus
casei) 		PF00186
(DHFR_1) 		5 ALA A  32
VAL A  74
VAL A  82
LEU A 114
ALA A   2
 None
 1.02A 6djzC-3dfrA:
undetectable		 6djzC-3dfrA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Clostridium
beijerinckii;
Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 MET A 140
ALA A 134
LEU A 136
VAL A 323
THR A 149
 None
 1.08A 6djzC-3fplA:
undetectable		 6djzC-3fplA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 MET A 406
VAL A 449
THR A 387
LEU A 388
ALA A 391
 None
 1.12A 6djzC-3hpaA:
undetectable		 6djzC-3hpaA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i99 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(Vibrio cholerae) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		5 PHE A 340
VAL A 338
LEU A 280
ALA A 277
TYR A 330
 None
 1.17A 6djzC-3i99A:
undetectable		 6djzC-3i99A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ive NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 ALA A 358
LEU A 356
PHE A 474
LEU A 351
TYR A 498
 None
 1.04A 6djzC-3iveA:
undetectable		 6djzC-3iveA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		5 ALA B 124
LEU B  60
HIS B 130
THR B  69
LEU B  72
 None
 1.12A 6djzC-3k70B:
undetectable		 6djzC-3k70B:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3li9 HYPOTHETICAL SENSORY
TRANSDUCTION
HISTIDINE KINASE

(Methanosarcina
mazei) 		PF02743
(dCache_1) 		5 ALA A  69
LEU A 106
SER A  81
THR A  75
ALA A  77
 None
 1.18A 6djzC-3li9A:
undetectable		 6djzC-3li9A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mnf PAC2 FAMILY PROTEIN

(Streptomyces
avermitilis) 		PF09754
(PAC2) 		5 ALA A  25
VAL A 231
THR A 202
LEU A 205
ALA A 204
 None
 1.16A 6djzC-3mnfA:
undetectable		 6djzC-3mnfA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzn GLUCARATE
DEHYDRATASE

(Chromohalobacter
salexigens) 		PF13378
(MR_MLE_C) 		5 ALA A  82
SER A 343
HIS A 311
LEU A 115
ALA A 114
 None
 1.18A 6djzC-3mznA:
undetectable		 6djzC-3mznA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzn GLUCARATE
DEHYDRATASE

(Chromohalobacter
salexigens) 		PF13378
(MR_MLE_C) 		5 LEU A  60
SER A 343
HIS A 311
LEU A 115
ALA A 114
 None
 1.09A 6djzC-3mznA:
undetectable		 6djzC-3mznA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfo PUTATIVE
ACETYLORNITHINE
DEACETYLASE

(Rhodopseudomonas
palustris) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 PHE A  55
VAL A 171
THR A 416
LEU A 417
ALA A 420
 None
 1.10A 6djzC-3pfoA:
undetectable		 6djzC-3pfoA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qv9 PYRUVATE KINASE 2

(Trypanosoma
cruzi) 		PF00224
(PK)
PF02887
(PK_C) 		5 ALA A  72
LEU A  38
SER A 331
VAL A 343
LEU A  81
 None
None
PO4  A 501 (-4.3A)
None
None
 1.12A 6djzC-3qv9A:
undetectable		 6djzC-3qv9A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rre PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		5 ALA A 339
SER A 429
HIS A 458
THR A 364
ALA A 343
 None
ADP  A 493 (-3.2A)
ADP  A 493 (-4.4A)
None
MG  A 492 ( 4.4A)
 1.08A 6djzC-3rreA:
undetectable		 6djzC-3rreA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5t PUTATIVE
GLYCOSYLTRANSFERASE

(Streptomyces
hygroscopicus) 		PF00982
(Glyco_transf_20) 		5 ALA A  28
LEU A  30
VAL A  45
LEU A  84
ALA A  52
 None
 0.96A 6djzC-3t5tA:
undetectable		 6djzC-3t5tA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v64 LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 4

(Rattus
norvegicus) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		5 ALA C 625
LEU C 627
THR C 604
LEU C 603
ALA C 560
 None
 0.78A 6djzC-3v64C:
undetectable		 6djzC-3v64C:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v65 LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 4

(Rattus
norvegicus) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		5 ALA B 625
LEU B 627
THR B 604
LEU B 603
ALA B 560
 None
 0.81A 6djzC-3v65B:
undetectable		 6djzC-3v65B:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX BETA-CHAIN
FADA

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ALA C 329
LEU C 388
VAL C 373
VAL C 267
LEU C 361
 None
 1.10A 6djzC-4b3iC:
undetectable		 6djzC-4b3iC:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bok ALPHA-1,6-MANNANASE

(Bacillus
circulans) 		PF03663
(Glyco_hydro_76) 		5 MET A 127
ALA A 207
HIS A 308
LEU A 195
ALA A 134
 None
 0.99A 6djzC-4bokA:
undetectable		 6djzC-4bokA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE

(Pseudomonas
aeruginosa) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ALA A 105
PHE A 269
VAL A 290
VAL A 280
LEU A 124
 None
 1.12A 6djzC-4cvmA:
undetectable		 6djzC-4cvmA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Methanosarcina
mazei) 		PF01458
(UPF0051) 		5 ALA A 120
SER A  35
THR A 158
LEU A 189
ALA A 156
 None
 1.02A 6djzC-4dn7A:
undetectable		 6djzC-4dn7A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzt AQUALYSIN-1

(Thermus
aquaticus) 		PF00082
(Peptidase_S8) 		5 ALA A  93
LEU A  91
VAL A 231
HIS A 227
ALA A 207
 None
 1.01A 6djzC-4dztA:
undetectable		 6djzC-4dztA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0q RESTRICTION
ENDONUCLEASE

(Mycobacterium
sp. JLS) 		PF04471
(Mrr_cat) 		5 MET A 421
ALA A 308
PHE A 115
THR A 413
LEU A 414
 None
 1.07A 6djzC-4f0qA:
undetectable		 6djzC-4f0qA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxq ARGINASE-1

(Homo sapiens) 		PF00491
(Arginase) 		6 ALA A  34
LEU A  37
SER A  94
VAL A  87
THR A 300
LEU A 301
 None
 1.33A 6djzC-4hxqA:
undetectable		 6djzC-4hxqA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l27 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		no annotation 5 ALA B 158
LEU B 154
VAL B 314
LEU B 136
TYR B 163
 None
None
HEM  B 602 (-4.1A)
None
None
 1.12A 6djzC-4l27B:
undetectable		 6djzC-4l27B:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkn TRIOSEPHOSPHATE
ISOMERASE

(Chlamydomonas
reinhardtii) 		PF00121
(TIM) 		5 SER A  62
PHE A   7
VAL A 163
VAL A  40
THR A  84
 None
 0.85A 6djzC-4mknA:
undetectable		 6djzC-4mknA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B

(Vibrio cholerae) 		PF03116
(NQR2_RnfD_RnfE) 		5 ALA B 235
LEU B 249
VAL B 275
THR B 227
ALA B  82
 None
 1.16A 6djzC-4p6vB:
undetectable		 6djzC-4p6vB:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis) 		PF07568
(HisKA_2)
PF13581
(HATPase_c_2) 		5 LEU A 266
VAL A 308
THR A 249
LEU A 252
ALA A 251
 None
None
None
None
ANP  A 402 ( 4.1A)
 1.15A 6djzC-4r39A:
undetectable		 6djzC-4r39A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjk ACETOLACTATE
SYNTHASE

(Bacillus
subtilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A  96
PHE A 156
VAL A 152
VAL A  30
ALA A  64
 None
 1.10A 6djzC-4rjkA:
undetectable		 6djzC-4rjkA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE

(Synechocystis
sp. PCC 6803) 		no annotation 5 ALA B  33
LEU B 219
VAL B 110
LEU B  27
ALA B 212
 None
 1.11A 6djzC-4rziB:
undetectable		 6djzC-4rziB:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u14 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3

(Rattus
norvegicus;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 PHE A 105
VAL A 160
THR A 174
LEU A 173
ALA A 177
 None
 0.91A 6djzC-4u14A:
undetectable		 6djzC-4u14A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2i ESTERASE/LIPASE

(Thalassospira
sp. GB04J01) 		PF07859
(Abhydrolase_3) 		5 ALA A 181
LEU A 152
VAL A  65
VAL A  57
ALA A 171
 None
 1.10A 6djzC-4v2iA:
undetectable		 6djzC-4v2iA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 2
ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Drosophila
melanogaster;
Drosophila
melanogaster) 		PF04084
(ORC2)
PF13191
(AAA_16)
PF14630
(ORC5_C) 		5 PHE E 418
VAL E 411
HIS E 412
LEU B 451
ALA B 447
 None
 1.14A 6djzC-4xgcE:
undetectable		 6djzC-4xgcE:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xq2 CALE6

(Micromonospora
echinospora) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A 139
VAL A 155
THR A 103
LEU A 106
ALA A  80
 None
 1.17A 6djzC-4xq2A:
undetectable		 6djzC-4xq2A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		5 ALA A 354
LEU A 336
VAL A 407
LEU A 347
ALA A  69
 None
 1.13A 6djzC-5a4jA:
undetectable		 6djzC-5a4jA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC

(Chlamydomonas
reinhardtii) 		no annotation 5 LEU A 343
HIS A 297
VAL A 127
LEU A  82
ALA A  88
 None
 1.14A 6djzC-5b5xA:
undetectable		 6djzC-5b5xA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5btx LPG1496

(Legionella
pneumophila) 		no annotation 6 PHE A  29
VAL A  33
VAL A  93
THR A 108
ALA A  77
TYR A  61
 None
None
None
CMP  A 201 (-3.2A)
None
CMP  A 201 (-3.6A)
 1.49A 6djzC-5btxA:
undetectable		 6djzC-5btxA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC

(Bacillus
subtilis) 		PF00698
(Acyl_transf_1) 		5 SER A  87
VAL A 159
HIS A 193
ALA A  84
TYR A 254
 GOL  A 301 (-3.6A)
None
GOL  A 301 (-4.2A)
None
None
 1.13A 6djzC-5dz6A:
undetectable		 6djzC-5dz6A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5egi UNCHARACTERIZED
PROTEIN Y57A10A.10

(Caenorhabditis
elegans) 		PF05197
(TRIC) 		5 LEU A  80
SER A 138
HIS A 139
LEU A  75
ALA A 161
 None
None
None
None
PT5  A 301 ( 4.2A)
 1.02A 6djzC-5egiA:
undetectable		 6djzC-5egiA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gve DNA TOPOISOMERASE
3-BETA-1

(Homo sapiens) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 LEU A 301
HIS A 387
LEU A 328
ALA A 325
TYR A 409
 None
 1.09A 6djzC-5gveA:
undetectable		 6djzC-5gveA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2v IMPORTIN SUBUNIT
BETA-3

(Saccharomyces
cerevisiae) 		PF13513
(HEAT_EZ) 		5 LEU A 364
THR A 314
LEU A 315
ALA A 390
TYR A 371
 None
 1.16A 6djzC-5h2vA:
undetectable		 6djzC-5h2vA:
11.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hk2 SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1

(Homo sapiens) 		PF04622
(ERG2_Sigma1R) 		9 ALA A  98
SER A 117
PHE A 133
VAL A 152
HIS A 154
VAL A 162
THR A 181
LEU A 182
TYR A 206
 61V  A 301 ( 4.8A)
61V  A 301 (-2.9A)
None
None
61V  A 301 ( 4.1A)
None
61V  A 301 ( 4.7A)
None
61V  A 301 (-3.6A)
 0.84A 6djzC-5hk2A:
34.1		 6djzC-5hk2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hk2 SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1

(Homo sapiens) 		PF04622
(ERG2_Sigma1R) 		11 MET A  93
ALA A  98
LEU A 105
SER A 117
PHE A 133
VAL A 152
HIS A 154
VAL A 162
THR A 181
ALA A 185
TYR A 206
 61V  A 301 (-3.4A)
61V  A 301 ( 4.8A)
None
61V  A 301 (-2.9A)
None
None
61V  A 301 ( 4.1A)
None
61V  A 301 ( 4.7A)
61V  A 301 ( 4.2A)
61V  A 301 (-3.6A)
 0.51A 6djzC-5hk2A:
34.1		 6djzC-5hk2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hk2 SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1

(Homo sapiens) 		PF04622
(ERG2_Sigma1R) 		9 MET A  93
ALA A  98
LEU A 105
SER A 117
VAL A 153
HIS A 154
THR A 181
ALA A 185
TYR A 206
 61V  A 301 (-3.4A)
61V  A 301 ( 4.8A)
None
61V  A 301 (-2.9A)
None
61V  A 301 ( 4.1A)
61V  A 301 ( 4.7A)
61V  A 301 ( 4.2A)
61V  A 301 (-3.6A)
 1.45A 6djzC-5hk2A:
34.1		 6djzC-5hk2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I

(Geobacillus
stearothermophilus) 		PF01654
(Cyt_bd_oxida_I) 		5 ALA A 203
LEU A 199
VAL A  65
VAL A 135
ALA A  38
 None
None
HEB  A 502 (-3.4A)
None
None
 1.05A 6djzC-5ir6A:
undetectable		 6djzC-5ir6A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jy1 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Paraburkholderia
xenovorans) 		PF13561
(adh_short_C2) 		5 ALA A 125
LEU A  84
VAL A 228
THR A  12
ALA A  36
 ACT  A 306 ( 4.1A)
None
None
None
None
 1.14A 6djzC-5jy1A:
undetectable		 6djzC-5jy1A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m77 ALPHA-1,6-MANNANASE

(Bacillus
circulans) 		PF03422
(CBM_6)
PF03663
(Glyco_hydro_76) 		5 MET A 127
ALA A 207
HIS A 308
LEU A 195
ALA A 134
 None
None
EDO  A 605 ( 4.9A)
None
None
 1.01A 6djzC-5m77A:
undetectable		 6djzC-5m77A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nag KYNURENINE
3-MONOOXYGENASE

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		5 ALA A 177
VAL A  10
VAL A  22
LEU A 297
ALA A 313
 None
 0.94A 6djzC-5nagA:
undetectable		 6djzC-5nagA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nb3 PHYCOERYTHRIN ALPHA
SUBUNIT,PHYCOERYTHRI
N ALPHA
SUBUNIT,PHYCOERYTHRI
N ALPHA SUBUNIT
PHYCOERYTHRIN BETA
SUBUNIT,PHYCOERYTHRI
N BETA SUBUNIT

(Phormidium
rubidum;
Phormidium
rubidum) 		PF00502
(Phycobilisome)
PF00502
(Phycobilisome) 		5 ALA A 159
LEU A 155
SER M   6
VAL A   4
TYR A  89
 None
None
None
None
PEB  A 166 (-4.3A)
 1.07A 6djzC-5nb3A:
undetectable		 6djzC-5nb3A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngj TAIL TUBE PROTEIN

(Escherichia
virus T5) 		no annotation 5 LEU A 287
SER A 264
THR A 332
LEU A 269
TYR A 280
 None
 1.15A 6djzC-5ngjA:
undetectable		 6djzC-5ngjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 ALA A3512
THR A3153
LEU A3154
ALA A3157
TYR A3516
 None
 1.07A 6djzC-5nugA:
undetectable		 6djzC-5nugA:
3.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1w P2X PURINOCEPTOR

(Ailuropoda
melanoleuca) 		PF00864
(P2X_receptor) 		5 LEU A 278
PHE A 102
VAL A 104
VAL A 190
THR A 238
 None
 1.09A 6djzC-5u1wA:
undetectable		 6djzC-5u1wA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		5 LEU A 195
PHE A 159
VAL A 157
LEU A 222
ALA A 175
 None
 1.05A 6djzC-5u4hA:
undetectable		 6djzC-5u4hA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq3 CYTOKININ RIBOSIDE
5'-MONOPHOSPHATE
PHOSPHORIBOHYDROLASE

(Corynebacterium
glutamicum) 		PF03641
(Lysine_decarbox) 		5 LEU A  92
PHE A 194
VAL A 182
LEU A 111
TYR A  86
 None
 1.10A 6djzC-5wq3A:
undetectable		 6djzC-5wq3A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wsl KERATINASE

(Meiothermus
taiwanensis) 		no annotation 5 ALA A  95
LEU A  93
VAL A 233
HIS A 229
ALA A 209
 None
 0.92A 6djzC-5wslA:
undetectable		 6djzC-5wslA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7u TREHALOSE SYNTHASE

(Thermobaculum
terrenum) 		no annotation 5 ALA A 330
LEU A 348
HIS A 309
LEU A 314
TYR A 326
 None
 1.11A 6djzC-5x7uA:
undetectable		 6djzC-5x7uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3j TOLL-LIKE RECEPTOR 9

(Equus caballus) 		no annotation 5 LEU A 640
SER A 589
HIS A 588
VAL A 591
ALA A 615
 None
MG  A1011 (-2.7A)
None
None
None
 1.09A 6djzC-5y3jA:
undetectable		 6djzC-5y3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykb TREHALOSE SYNTHASE

(Deinococcus
radiodurans) 		no annotation 5 ALA A 339
LEU A 357
HIS A 318
LEU A 323
TYR A 335
 None
 1.18A 6djzC-5ykbA:
undetectable		 6djzC-5ykbA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxg PILUS ASSEMBLY
PROTEIN

(Lactobacillus
rhamnosus) 		no annotation 5 PHE A 216
VAL A 317
VAL A 240
THR A 322
LEU A 210
 None
 1.13A 6djzC-5yxgA:
undetectable		 6djzC-5yxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjb CYSTATHIONINE
BETA-LYASE

(Legionella
pneumophila) 		no annotation 5 LEU A 188
PHE A   6
THR A 146
LEU A 144
ALA A 173
 None
 1.11A 6djzC-6cjbA:
undetectable		 6djzC-6cjbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dch SCOE PROTEIN

(Streptomyces
coeruleorubidus) 		no annotation 5 ALA A  71
LEU A 285
VAL A 111
VAL A 106
LEU A  90
 None
 1.00A 6djzC-6dchA:
1.6		 6djzC-6dchA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dd6 PHOTOLYASE PHRB

(Agrobacterium
tumefaciens) 		no annotation 5 LEU A  12
PHE A  83
VAL A  34
VAL A 109
TYR A 271
 None
DLZ  A 602 (-4.2A)
DLZ  A 602 (-4.6A)
None
None
 1.12A 6djzC-6dd6A:
undetectable		 6djzC-6dd6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE

(Pseudomonas
nitroreducens) 		no annotation 5 ALA A  98
PHE A 227
VAL A 381
VAL A 238
TYR A 115
 None
 1.17A 6djzC-6em0A:
undetectable		 6djzC-6em0A:
undetectable