SIMILAR PATTERNS OF AMINO ACIDS FOR 6DJZ_C_GMJC301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjw ASPARTATE
AMINOTRANSFERASE


(Thermus
thermophilus)
PF00155
(Aminotran_1_2)
5 ALA A 235
PHE A 354
VAL A 126
VAL A 349
ALA A 365
LLP  A 234 ( 3.7A)
None
None
None
None
1.05A 6djzC-1bjwA:
0.0
6djzC-1bjwA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3r HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN)


(Aquifex
aeolicus)
PF00850
(Hist_deacetyl)
5 ALA A 169
LEU A 167
PHE A 286
LEU A 222
ALA A 234
ZN  A 501 ( 4.9A)
None
None
None
None
1.11A 6djzC-1c3rA:
0.0
6djzC-1c3rA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3


(Dictyostelium
discoideum)
PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N)
5 MET A 342
SER A 379
VAL A 384
LEU A 298
ALA A 349
None
1.11A 6djzC-1g8xA:
0.0
6djzC-1g8xA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg0 L-ASPARAGINASE

(Dickeya
chrysanthemi)
PF00710
(Asparaginase)
5 ALA A  42
PHE A 177
VAL A 154
HIS A  93
LEU A  34
None
1.05A 6djzC-1hg0A:
0.0
6djzC-1hg0A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE


(Serratia
marcescens)
PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N)
5 ALA A 458
LEU A   8
VAL A  13
LEU A 177
ALA A  58
None
1.11A 6djzC-1i7qA:
0.0
6djzC-1i7qA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqb NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Clostridium
beijerinckii)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 MET A1140
ALA A1134
LEU A1136
VAL A1323
THR A1149
None
1.15A 6djzC-1jqbA:
0.0
6djzC-1jqbA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A


(Dictyostelium
discoideum)
PF00063
(Myosin_head)
PF02736
(Myosin_N)
5 MET A 353
SER A 390
VAL A 395
LEU A 309
ALA A 360
None
1.16A 6djzC-1jx2A:
0.9
6djzC-1jx2A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7j D-AMINOACYLASE

(Alcaligenes
faecalis)
PF07969
(Amidohydro_3)
6 SER A 249
PHE A 413
VAL A  92
HIS A  67
VAL A 247
TYR A 389
None
None
None
ZN  A 802 ( 3.2A)
None
None
1.10A 6djzC-1m7jA:
undetectable
6djzC-1m7jA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE


(Escherichia
coli)
PF00275
(EPSP_synthase)
5 ALA A  59
LEU A  57
VAL A 239
LEU A  92
ALA A  98
None
0.99A 6djzC-1p88A:
0.0
6djzC-1p88A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE


(Mycobacterium
tuberculosis)
PF01729
(QRPTase_C)
PF02749
(QRPTase_N)
5 LEU A  45
VAL A 278
THR A  62
ALA A 103
TYR A  72
None
1.17A 6djzC-1qpoA:
undetectable
6djzC-1qpoA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE


(Pseudomonas
putida)
PF00206
(Lyase_1)
PF10397
(ADSL_C)
5 SER A 246
HIS A 176
VAL A 169
LEU A 333
ALA A 294
None
1.04A 6djzC-1re5A:
undetectable
6djzC-1re5A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14


(Mus musculus)
no annotation 5 ALA A  80
LEU A  40
PHE A  30
LEU A  87
ALA A  90
None
1.07A 6djzC-1wwlA:
undetectable
6djzC-1wwlA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2


(Archaeoglobus
fulgidus)
PF02552
(CO_dh)
5 LEU A  88
PHE A  74
VAL A  83
VAL A  54
LEU A 126
None
1.13A 6djzC-1ytlA:
undetectable
6djzC-1ytlA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2coc FYVE, RHOGEF AND PH
DOMAIN CONTAINING
PROTEIN 3


(Homo sapiens)
no annotation 5 ALA A  28
SER A 111
THR A 100
LEU A 101
ALA A 104
None
1.11A 6djzC-2cocA:
undetectable
6djzC-2cocA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE


(Thermus
thermophilus)
PF01053
(Cys_Met_Meta_PP)
5 LEU A  67
VAL A 179
THR A  79
LEU A 272
ALA A 216
None
1.06A 6djzC-2ctzA:
undetectable
6djzC-2ctzA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Pyrococcus
horikoshii)
PF00478
(IMPDH)
PF00571
(CBS)
5 ALA A 222
LEU A  51
VAL A  36
THR A  41
ALA A 290
None
1.15A 6djzC-2cu0A:
undetectable
6djzC-2cu0A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE


(Thermus
thermophilus)
PF00596
(Aldolase_II)
5 ALA A 161
LEU A   5
VAL A  57
HIS A  74
LEU A 167
None
1.15A 6djzC-2fk5A:
undetectable
6djzC-2fk5A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jk0 L-ASPARAGINASE

(Pectobacterium
carotovorum)
PF00710
(Asparaginase)
5 ALA A  42
PHE A 177
VAL A 154
HIS A  93
LEU A  34
None
1.04A 6djzC-2jk0A:
undetectable
6djzC-2jk0A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nc8 LIPOPROTEIN LPPM

(Mycobacterium
tuberculosis)
no annotation 5 ALA A 125
LEU A 110
PHE A  66
VAL A  70
ALA A  30
None
1.17A 6djzC-2nc8A:
undetectable
6djzC-2nc8A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE


(Mycobacterium
tuberculosis)
PF00275
(EPSP_synthase)
5 MET A 386
ALA A 346
VAL A 397
LEU A 366
ALA A 317
None
1.15A 6djzC-2o0xA:
undetectable
6djzC-2o0xA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6t DNAB REPLICATION
FORK HELICASE


(Thermus
aquaticus)
PF00772
(DnaB)
PF03796
(DnaB_C)
5 LEU A 359
VAL A 415
THR A 219
LEU A 218
ALA A 221
None
1.17A 6djzC-2q6tA:
undetectable
6djzC-2q6tA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlt (DL)-GLYCEROL-3-PHOS
PHATASE 1


(Saccharomyces
cerevisiae)
PF13419
(HAD_2)
5 ALA A 126
LEU A 124
SER A 241
VAL A 114
VAL A 236
None
1.03A 6djzC-2qltA:
undetectable
6djzC-2qltA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyg RIBULOSE
BISPHOSPHATE
CARBOXYLASE-LIKE
PROTEIN 2


(Rhodopseudomonas
palustris)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
5 ALA A 314
LEU A 310
PHE A  26
HIS A 100
VAL A 121
None
1.17A 6djzC-2qygA:
undetectable
6djzC-2qygA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ral SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN G


(Staphylococcus
epidermidis)
PF10425
(SdrG_C_C)
5 LEU A 497
PHE A 530
VAL A 488
VAL A 467
TYR A 424
None
1.09A 6djzC-2ralA:
2.3
6djzC-2ralA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgw ASPARTATE
CARBAMOYLTRANSFERASE


(Methanocaldococcus
jannaschii)
PF00185
(OTCace)
PF02729
(OTCace_N)
5 ALA A 294
LEU A 299
VAL A  46
THR A 133
LEU A 136
None
1.16A 6djzC-2rgwA:
undetectable
6djzC-2rgwA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN


(Staphylococcus
haemolyticus)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5)
5 ALA B 693
LEU B 689
PHE B 622
LEU B 638
ALA B 633
None
1.08A 6djzC-2rhqB:
undetectable
6djzC-2rhqB:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vcy TRANS-2-ENOYL-COA
REDUCTASE


(Homo sapiens)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ALA A 206
LEU A 340
VAL A 152
LEU A 175
ALA A 171
None
1.07A 6djzC-2vcyA:
undetectable
6djzC-2vcyA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei)
PF00686
(CBM_20)
PF00723
(Glyco_hydro_15)
5 ALA A 195
PHE A 470
VAL A 154
LEU A 130
ALA A  56
None
1.13A 6djzC-2vn7A:
undetectable
6djzC-2vn7A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vro ALDEHYDE
DEHYDROGENASE


(Paraburkholderia
xenovorans)
PF00171
(Aldedh)
5 ALA A 381
LEU A 320
PHE A 280
VAL A 304
ALA A 361
None
0.99A 6djzC-2vroA:
undetectable
6djzC-2vroA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vro ALDEHYDE
DEHYDROGENASE


(Paraburkholderia
xenovorans)
PF00171
(Aldedh)
5 ALA A 381
LEU A 320
PHE A 280
VAL A 304
LEU A 360
None
1.15A 6djzC-2vroA:
undetectable
6djzC-2vroA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1c ACYL-COENZYME

(Penicillium
chrysogenum)
PF03417
(AAT)
5 ALA A 211
LEU A 224
LEU A 185
ALA A 188
TYR A 166
None
1.11A 6djzC-2x1cA:
undetectable
6djzC-2x1cA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR


(Methanothermobacter
thermautotrophicus)
PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7)
5 ALA A 237
VAL A 633
LEU A 322
ALA A 336
TYR A 264
None
1.16A 6djzC-2ycbA:
undetectable
6djzC-2ycbA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III


(Thermus
thermophilus)
PF00115
(COX1)
PF00510
(COX3)
5 ALA A 754
PHE A 589
THR A 766
LEU A 767
ALA A 770
None
None
5PL  A 900 (-2.8A)
None
5PL  A 900 ( 4.3A)
1.00A 6djzC-2yevA:
undetectable
6djzC-2yevA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a77 INTERFERON
REGULATORY FACTOR 3


(Homo sapiens)
PF10401
(IRF-3)
5 ALA A 283
LEU A 281
SER A 396
VAL A 197
LEU A 226
None
1.06A 6djzC-3a77A:
undetectable
6djzC-3a77A:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT


(Sphingomonas
sp. A1)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
6 ALA B  91
LEU B 101
PHE B  52
HIS B 201
THR B  78
LEU B  85
None
1.50A 6djzC-3amjB:
undetectable
6djzC-3amjB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnj CHOLESTEROL OXIDASE

(Streptomyces
sp. SA-COO)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 ALA A 441
VAL A 482
VAL A 124
LEU A 375
ALA A 363
None
1.09A 6djzC-3cnjA:
undetectable
6djzC-3cnjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpx AMINOPEPTIDASE, M42
FAMILY


(Cytophaga
hutchinsonii)
PF05343
(Peptidase_M42)
5 ALA A 180
LEU A 257
THR A 169
ALA A 167
TYR A 181
EDO  A 406 (-3.5A)
None
None
None
None
1.13A 6djzC-3cpxA:
undetectable
6djzC-3cpxA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddm PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME


(Bordetella
bronchiseptica)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 LEU A 374
VAL A  45
VAL A  73
LEU A 344
ALA A  40
None
1.11A 6djzC-3ddmA:
undetectable
6djzC-3ddmA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfr DIHYDROFOLATE
REDUCTASE


(Lactobacillus
casei)
PF00186
(DHFR_1)
5 ALA A  32
VAL A  74
VAL A  82
LEU A 114
ALA A   2
None
1.02A 6djzC-3dfrA:
undetectable
6djzC-3dfrA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Clostridium
beijerinckii;
Thermoanaerobacter
brockii)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 MET A 140
ALA A 134
LEU A 136
VAL A 323
THR A 149
None
1.08A 6djzC-3fplA:
undetectable
6djzC-3fplA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified)
PF01979
(Amidohydro_1)
5 MET A 406
VAL A 449
THR A 387
LEU A 388
ALA A 391
None
1.12A 6djzC-3hpaA:
undetectable
6djzC-3hpaA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i99 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE


(Vibrio cholerae)
PF01565
(FAD_binding_4)
PF02873
(MurB_C)
5 PHE A 340
VAL A 338
LEU A 280
ALA A 277
TYR A 330
None
1.17A 6djzC-3i99A:
undetectable
6djzC-3i99A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ive NUCLEOTIDASE

(Escherichia
coli)
PF00149
(Metallophos)
PF02872
(5_nucleotid_C)
5 ALA A 358
LEU A 356
PHE A 474
LEU A 351
TYR A 498
None
1.04A 6djzC-3iveA:
undetectable
6djzC-3iveA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN


(Escherichia
coli)
PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C)
5 ALA B 124
LEU B  60
HIS B 130
THR B  69
LEU B  72
None
1.12A 6djzC-3k70B:
undetectable
6djzC-3k70B:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3li9 HYPOTHETICAL SENSORY
TRANSDUCTION
HISTIDINE KINASE


(Methanosarcina
mazei)
PF02743
(dCache_1)
5 ALA A  69
LEU A 106
SER A  81
THR A  75
ALA A  77
None
1.18A 6djzC-3li9A:
undetectable
6djzC-3li9A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mnf PAC2 FAMILY PROTEIN

(Streptomyces
avermitilis)
PF09754
(PAC2)
5 ALA A  25
VAL A 231
THR A 202
LEU A 205
ALA A 204
None
1.16A 6djzC-3mnfA:
undetectable
6djzC-3mnfA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzn GLUCARATE
DEHYDRATASE


(Chromohalobacter
salexigens)
PF13378
(MR_MLE_C)
5 ALA A  82
SER A 343
HIS A 311
LEU A 115
ALA A 114
None
1.18A 6djzC-3mznA:
undetectable
6djzC-3mznA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzn GLUCARATE
DEHYDRATASE


(Chromohalobacter
salexigens)
PF13378
(MR_MLE_C)
5 LEU A  60
SER A 343
HIS A 311
LEU A 115
ALA A 114
None
1.09A 6djzC-3mznA:
undetectable
6djzC-3mznA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfo PUTATIVE
ACETYLORNITHINE
DEACETYLASE


(Rhodopseudomonas
palustris)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 PHE A  55
VAL A 171
THR A 416
LEU A 417
ALA A 420
None
1.10A 6djzC-3pfoA:
undetectable
6djzC-3pfoA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qv9 PYRUVATE KINASE 2

(Trypanosoma
cruzi)
PF00224
(PK)
PF02887
(PK_C)
5 ALA A  72
LEU A  38
SER A 331
VAL A 343
LEU A  81
None
None
PO4  A 501 (-4.3A)
None
None
1.12A 6djzC-3qv9A:
undetectable
6djzC-3qv9A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rre PUTATIVE
UNCHARACTERIZED
PROTEIN


(Thermotoga
maritima)
PF01256
(Carb_kinase)
PF03853
(YjeF_N)
5 ALA A 339
SER A 429
HIS A 458
THR A 364
ALA A 343
None
ADP  A 493 (-3.2A)
ADP  A 493 (-4.4A)
None
MG  A 492 ( 4.4A)
1.08A 6djzC-3rreA:
undetectable
6djzC-3rreA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5t PUTATIVE
GLYCOSYLTRANSFERASE


(Streptomyces
hygroscopicus)
PF00982
(Glyco_transf_20)
5 ALA A  28
LEU A  30
VAL A  45
LEU A  84
ALA A  52
None
0.96A 6djzC-3t5tA:
undetectable
6djzC-3t5tA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v64 LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 4


(Rattus
norvegicus)
PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition)
5 ALA C 625
LEU C 627
THR C 604
LEU C 603
ALA C 560
None
0.78A 6djzC-3v64C:
undetectable
6djzC-3v64C:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v65 LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 4


(Rattus
norvegicus)
PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition)
5 ALA B 625
LEU B 627
THR B 604
LEU B 603
ALA B 560
None
0.81A 6djzC-3v65B:
undetectable
6djzC-3v65B:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX BETA-CHAIN
FADA


(Mycobacterium
tuberculosis)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 ALA C 329
LEU C 388
VAL C 373
VAL C 267
LEU C 361
None
1.10A 6djzC-4b3iC:
undetectable
6djzC-4b3iC:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bok ALPHA-1,6-MANNANASE

(Bacillus
circulans)
PF03663
(Glyco_hydro_76)
5 MET A 127
ALA A 207
HIS A 308
LEU A 195
ALA A 134
None
0.99A 6djzC-4bokA:
undetectable
6djzC-4bokA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE


(Pseudomonas
aeruginosa)
PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
5 ALA A 105
PHE A 269
VAL A 290
VAL A 280
LEU A 124
None
1.12A 6djzC-4cvmA:
undetectable
6djzC-4cvmA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN


(Methanosarcina
mazei)
PF01458
(UPF0051)
5 ALA A 120
SER A  35
THR A 158
LEU A 189
ALA A 156
None
1.02A 6djzC-4dn7A:
undetectable
6djzC-4dn7A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzt AQUALYSIN-1

(Thermus
aquaticus)
PF00082
(Peptidase_S8)
5 ALA A  93
LEU A  91
VAL A 231
HIS A 227
ALA A 207
None
1.01A 6djzC-4dztA:
undetectable
6djzC-4dztA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0q RESTRICTION
ENDONUCLEASE


(Mycobacterium
sp. JLS)
PF04471
(Mrr_cat)
5 MET A 421
ALA A 308
PHE A 115
THR A 413
LEU A 414
None
1.07A 6djzC-4f0qA:
undetectable
6djzC-4f0qA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxq ARGINASE-1

(Homo sapiens)
PF00491
(Arginase)
6 ALA A  34
LEU A  37
SER A  94
VAL A  87
THR A 300
LEU A 301
None
1.33A 6djzC-4hxqA:
undetectable
6djzC-4hxqA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l27 CYSTATHIONINE
BETA-SYNTHASE


(Homo sapiens)
no annotation 5 ALA B 158
LEU B 154
VAL B 314
LEU B 136
TYR B 163
None
None
HEM  B 602 (-4.1A)
None
None
1.12A 6djzC-4l27B:
undetectable
6djzC-4l27B:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkn TRIOSEPHOSPHATE
ISOMERASE


(Chlamydomonas
reinhardtii)
PF00121
(TIM)
5 SER A  62
PHE A   7
VAL A 163
VAL A  40
THR A  84
None
0.85A 6djzC-4mknA:
undetectable
6djzC-4mknA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B


(Vibrio cholerae)
PF03116
(NQR2_RnfD_RnfE)
5 ALA B 235
LEU B 249
VAL B 275
THR B 227
ALA B  82
None
1.16A 6djzC-4p6vB:
undetectable
6djzC-4p6vB:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2


(Erythrobacter
litoralis)
PF07568
(HisKA_2)
PF13581
(HATPase_c_2)
5 LEU A 266
VAL A 308
THR A 249
LEU A 252
ALA A 251
None
None
None
None
ANP  A 402 ( 4.1A)
1.15A 6djzC-4r39A:
undetectable
6djzC-4r39A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjk ACETOLACTATE
SYNTHASE


(Bacillus
subtilis)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 LEU A  96
PHE A 156
VAL A 152
VAL A  30
ALA A  64
None
1.10A 6djzC-4rjkA:
undetectable
6djzC-4rjkA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE


(Synechocystis
sp. PCC 6803)
no annotation 5 ALA B  33
LEU B 219
VAL B 110
LEU B  27
ALA B 212
None
1.11A 6djzC-4rziB:
undetectable
6djzC-4rziB:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u14 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3


(Rattus
norvegicus;
Escherichia
virus T4)
PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
5 PHE A 105
VAL A 160
THR A 174
LEU A 173
ALA A 177
None
0.91A 6djzC-4u14A:
undetectable
6djzC-4u14A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2i ESTERASE/LIPASE

(Thalassospira
sp. GB04J01)
PF07859
(Abhydrolase_3)
5 ALA A 181
LEU A 152
VAL A  65
VAL A  57
ALA A 171
None
1.10A 6djzC-4v2iA:
undetectable
6djzC-4v2iA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 2
ORIGIN RECOGNITION
COMPLEX SUBUNIT 5


(Drosophila
melanogaster;
Drosophila
melanogaster)
PF04084
(ORC2)
PF13191
(AAA_16)
PF14630
(ORC5_C)
5 PHE E 418
VAL E 411
HIS E 412
LEU B 451
ALA B 447
None
1.14A 6djzC-4xgcE:
undetectable
6djzC-4xgcE:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xq2 CALE6

(Micromonospora
echinospora)
PF01053
(Cys_Met_Meta_PP)
5 LEU A 139
VAL A 155
THR A 103
LEU A 106
ALA A  80
None
1.17A 6djzC-4xq2A:
undetectable
6djzC-4xq2A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE


(Tepidanaerobacter
acetatoxydans)
PF01268
(FTHFS)
5 ALA A 354
LEU A 336
VAL A 407
LEU A 347
ALA A  69
None
1.13A 6djzC-5a4jA:
undetectable
6djzC-5a4jA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC


(Chlamydomonas
reinhardtii)
no annotation 5 LEU A 343
HIS A 297
VAL A 127
LEU A  82
ALA A  88
None
1.14A 6djzC-5b5xA:
undetectable
6djzC-5b5xA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5btx LPG1496

(Legionella
pneumophila)
no annotation 6 PHE A  29
VAL A  33
VAL A  93
THR A 108
ALA A  77
TYR A  61
None
None
None
CMP  A 201 (-3.2A)
None
CMP  A 201 (-3.6A)
1.49A 6djzC-5btxA:
undetectable
6djzC-5btxA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC


(Bacillus
subtilis)
PF00698
(Acyl_transf_1)
5 SER A  87
VAL A 159
HIS A 193
ALA A  84
TYR A 254
GOL  A 301 (-3.6A)
None
GOL  A 301 (-4.2A)
None
None
1.13A 6djzC-5dz6A:
undetectable
6djzC-5dz6A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5egi UNCHARACTERIZED
PROTEIN Y57A10A.10


(Caenorhabditis
elegans)
PF05197
(TRIC)
5 LEU A  80
SER A 138
HIS A 139
LEU A  75
ALA A 161
None
None
None
None
PT5  A 301 ( 4.2A)
1.02A 6djzC-5egiA:
undetectable
6djzC-5egiA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gve DNA TOPOISOMERASE
3-BETA-1


(Homo sapiens)
PF01131
(Topoisom_bac)
PF01751
(Toprim)
5 LEU A 301
HIS A 387
LEU A 328
ALA A 325
TYR A 409
None
1.09A 6djzC-5gveA:
undetectable
6djzC-5gveA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2v IMPORTIN SUBUNIT
BETA-3


(Saccharomyces
cerevisiae)
PF13513
(HEAT_EZ)
5 LEU A 364
THR A 314
LEU A 315
ALA A 390
TYR A 371
None
1.16A 6djzC-5h2vA:
undetectable
6djzC-5h2vA:
11.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hk2 SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1


(Homo sapiens)
PF04622
(ERG2_Sigma1R)
9 ALA A  98
SER A 117
PHE A 133
VAL A 152
HIS A 154
VAL A 162
THR A 181
LEU A 182
TYR A 206
61V  A 301 ( 4.8A)
61V  A 301 (-2.9A)
None
None
61V  A 301 ( 4.1A)
None
61V  A 301 ( 4.7A)
None
61V  A 301 (-3.6A)
0.84A 6djzC-5hk2A:
34.1
6djzC-5hk2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hk2 SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1


(Homo sapiens)
PF04622
(ERG2_Sigma1R)
11 MET A  93
ALA A  98
LEU A 105
SER A 117
PHE A 133
VAL A 152
HIS A 154
VAL A 162
THR A 181
ALA A 185
TYR A 206
61V  A 301 (-3.4A)
61V  A 301 ( 4.8A)
None
61V  A 301 (-2.9A)
None
None
61V  A 301 ( 4.1A)
None
61V  A 301 ( 4.7A)
61V  A 301 ( 4.2A)
61V  A 301 (-3.6A)
0.51A 6djzC-5hk2A:
34.1
6djzC-5hk2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hk2 SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1


(Homo sapiens)
PF04622
(ERG2_Sigma1R)
9 MET A  93
ALA A  98
LEU A 105
SER A 117
VAL A 153
HIS A 154
THR A 181
ALA A 185
TYR A 206
61V  A 301 (-3.4A)
61V  A 301 ( 4.8A)
None
61V  A 301 (-2.9A)
None
61V  A 301 ( 4.1A)
61V  A 301 ( 4.7A)
61V  A 301 ( 4.2A)
61V  A 301 (-3.6A)
1.45A 6djzC-5hk2A:
34.1
6djzC-5hk2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I


(Geobacillus
stearothermophilus)
PF01654
(Cyt_bd_oxida_I)
5 ALA A 203
LEU A 199
VAL A  65
VAL A 135
ALA A  38
None
None
HEB  A 502 (-3.4A)
None
None
1.05A 6djzC-5ir6A:
undetectable
6djzC-5ir6A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jy1 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE


(Paraburkholderia
xenovorans)
PF13561
(adh_short_C2)
5 ALA A 125
LEU A  84
VAL A 228
THR A  12
ALA A  36
ACT  A 306 ( 4.1A)
None
None
None
None
1.14A 6djzC-5jy1A:
undetectable
6djzC-5jy1A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m77 ALPHA-1,6-MANNANASE

(Bacillus
circulans)
PF03422
(CBM_6)
PF03663
(Glyco_hydro_76)
5 MET A 127
ALA A 207
HIS A 308
LEU A 195
ALA A 134
None
None
EDO  A 605 ( 4.9A)
None
None
1.01A 6djzC-5m77A:
undetectable
6djzC-5m77A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nag KYNURENINE
3-MONOOXYGENASE


(Pseudomonas
fluorescens)
PF01494
(FAD_binding_3)
5 ALA A 177
VAL A  10
VAL A  22
LEU A 297
ALA A 313
None
0.94A 6djzC-5nagA:
undetectable
6djzC-5nagA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nb3 PHYCOERYTHRIN ALPHA
SUBUNIT,PHYCOERYTHRI
N ALPHA
SUBUNIT,PHYCOERYTHRI
N ALPHA SUBUNIT
PHYCOERYTHRIN BETA
SUBUNIT,PHYCOERYTHRI
N BETA SUBUNIT


(Phormidium
rubidum;
Phormidium
rubidum)
PF00502
(Phycobilisome)
PF00502
(Phycobilisome)
5 ALA A 159
LEU A 155
SER M   6
VAL A   4
TYR A  89
None
None
None
None
PEB  A 166 (-4.3A)
1.07A 6djzC-5nb3A:
undetectable
6djzC-5nb3A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngj TAIL TUBE PROTEIN

(Escherichia
virus T5)
no annotation 5 LEU A 287
SER A 264
THR A 332
LEU A 269
TYR A 280
None
1.15A 6djzC-5ngjA:
undetectable
6djzC-5ngjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1


(Homo sapiens)
PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9)
5 ALA A3512
THR A3153
LEU A3154
ALA A3157
TYR A3516
None
1.07A 6djzC-5nugA:
undetectable
6djzC-5nugA:
3.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1w P2X PURINOCEPTOR

(Ailuropoda
melanoleuca)
PF00864
(P2X_receptor)
5 LEU A 278
PHE A 102
VAL A 104
VAL A 190
THR A 238
None
1.09A 6djzC-5u1wA:
undetectable
6djzC-5u1wA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Acinetobacter
baumannii)
PF00275
(EPSP_synthase)
5 LEU A 195
PHE A 159
VAL A 157
LEU A 222
ALA A 175
None
1.05A 6djzC-5u4hA:
undetectable
6djzC-5u4hA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq3 CYTOKININ RIBOSIDE
5'-MONOPHOSPHATE
PHOSPHORIBOHYDROLASE


(Corynebacterium
glutamicum)
PF03641
(Lysine_decarbox)
5 LEU A  92
PHE A 194
VAL A 182
LEU A 111
TYR A  86
None
1.10A 6djzC-5wq3A:
undetectable
6djzC-5wq3A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wsl KERATINASE

(Meiothermus
taiwanensis)
no annotation 5 ALA A  95
LEU A  93
VAL A 233
HIS A 229
ALA A 209
None
0.92A 6djzC-5wslA:
undetectable
6djzC-5wslA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7u TREHALOSE SYNTHASE

(Thermobaculum
terrenum)
no annotation 5 ALA A 330
LEU A 348
HIS A 309
LEU A 314
TYR A 326
None
1.11A 6djzC-5x7uA:
undetectable
6djzC-5x7uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3j TOLL-LIKE RECEPTOR 9

(Equus caballus)
no annotation 5 LEU A 640
SER A 589
HIS A 588
VAL A 591
ALA A 615
None
MG  A1011 (-2.7A)
None
None
None
1.09A 6djzC-5y3jA:
undetectable
6djzC-5y3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykb TREHALOSE SYNTHASE

(Deinococcus
radiodurans)
no annotation 5 ALA A 339
LEU A 357
HIS A 318
LEU A 323
TYR A 335
None
1.18A 6djzC-5ykbA:
undetectable
6djzC-5ykbA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxg PILUS ASSEMBLY
PROTEIN


(Lactobacillus
rhamnosus)
no annotation 5 PHE A 216
VAL A 317
VAL A 240
THR A 322
LEU A 210
None
1.13A 6djzC-5yxgA:
undetectable
6djzC-5yxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjb CYSTATHIONINE
BETA-LYASE


(Legionella
pneumophila)
no annotation 5 LEU A 188
PHE A   6
THR A 146
LEU A 144
ALA A 173
None
1.11A 6djzC-6cjbA:
undetectable
6djzC-6cjbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dch SCOE PROTEIN

(Streptomyces
coeruleorubidus)
no annotation 5 ALA A  71
LEU A 285
VAL A 111
VAL A 106
LEU A  90
None
1.00A 6djzC-6dchA:
1.6
6djzC-6dchA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dd6 PHOTOLYASE PHRB

(Agrobacterium
tumefaciens)
no annotation 5 LEU A  12
PHE A  83
VAL A  34
VAL A 109
TYR A 271
None
DLZ  A 602 (-4.2A)
DLZ  A 602 (-4.6A)
None
None
1.12A 6djzC-6dd6A:
undetectable
6djzC-6dd6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE


(Pseudomonas
nitroreducens)
no annotation 5 ALA A  98
PHE A 227
VAL A 381
VAL A 238
TYR A 115
None
1.17A 6djzC-6em0A:
undetectable
6djzC-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bev BOVINE ENTEROVIRUS
COAT PROTEINS VP1 TO
VP4
BOVINE ENTEROVIRUS
COAT PROTEINS VP1 TO
VP4


(Enterovirus E;
Enterovirus E)
PF00073
(Rhv)
PF00073
(Rhv)
4 TRP 1 111
LEU 3  94
ASP 3 234
GLN 1 104
None
1.43A 6djzC-1bev1:
0.6
6djzC-1bev1:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7j PROTEIN
(PARA-NITROBENZYL
ESTERASE)


(Bacillus
subtilis)
PF00135
(COesterase)
4 LEU A 401
TYR A 118
GLN A 162
GLU A 188
None
1.31A 6djzC-1c7jA:
undetectable
6djzC-1c7jA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwa MYROSINASE MA1

(Sinapis alba)
PF00232
(Glyco_hydro_1)
4 TRP M 100
LEU M 232
TYR M 152
GLN M 146
None
None
None
GOL  M 933 (-3.4A)
1.31A 6djzC-1dwaM:
undetectable
6djzC-1dwaM:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT


(Methanopyrus
kandleri;
Methanopyrus
kandleri)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
4 LEU A 469
TYR B 191
ASP B 229
GLN B 221
None
1.32A 6djzC-1e6vA:
undetectable
6djzC-1e6vA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hmd HEMERYTHRIN

(Themiste
dyscritum)
no annotation 4 TRP A  97
LEU A  56
ASP A 106
GLU A  58
None
None
FEO  A 115 (-2.6A)
FEO  A 115 (-2.5A)
1.39A 6djzC-1hmdA:
undetectable
6djzC-1hmdA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0h NEOPULLULANASE

(Geobacillus
stearothermophilus)
PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C)
4 TRP A 160
LEU A 175
TYR A 457
GLN A 482
None
1.21A 6djzC-1j0hA:
3.0
6djzC-1j0hA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jf5 ALPHA AMYLASE II

(Thermoactinomyces
vulgaris)
PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C)
4 TRP A 156
LEU A 172
TYR A 454
GLN A 479
None
1.29A 6djzC-1jf5A:
2.3
6djzC-1jf5A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkr 3-METHYLASPARTATE
AMMONIA-LYASE


(Citrobacter
amalonaticus)
PF05034
(MAAL_N)
PF07476
(MAAL_C)
4 LEU A 245
TYR A  74
ASP A 238
GLN A 172
None
None
MG  A 501 ( 2.6A)
2AS  A 801 (-3.1A)
1.20A 6djzC-1kkrA:
0.9
6djzC-1kkrA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster)
PF00135
(COesterase)
4 LEU A 479
TYR A 162
GLN A 211
GLU A 237
None
None
None
I40  A 997 (-4.2A)
1.42A 6djzC-1qonA:
undetectable
6djzC-1qonA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC


(Escherichia
coli)
PF03009
(GDPD)
4 LEU A 215
TYR A 313
ASP A  65
GLU A 171
None
GOL  A1605 (-3.8A)
MG  A1601 ( 2.7A)
MG  A1601 ( 2.9A)
1.06A 6djzC-1t8qA:
undetectable
6djzC-1t8qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1


(Thermus
thermophilus)
PF02347
(GDC-P)
4 LEU A 214
TYR A 163
ASP A 233
GLN A 256
None
1.49A 6djzC-1wytA:
undetectable
6djzC-1wytA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddx BETA-1,3-XYLANASE

(Vibrio sp. AX-4)
no annotation 4 LEU A 297
TYR A 267
ASP A 289
GLN A 275
None
1.47A 6djzC-2ddxA:
undetectable
6djzC-2ddxA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3z BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium)
PF00232
(Glyco_hydro_1)
4 TRP A  82
LEU A 203
TYR A 134
GLN A 128
None
1.25A 6djzC-2e3zA:
undetectable
6djzC-2e3zA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum)
PF14498
(Glyco_hyd_65N_2)
4 LEU A 534
TYR A 520
ASP A 689
GLN A 781
None
None
CA  A 902 (-2.9A)
None
1.49A 6djzC-2eaeA:
undetectable
6djzC-2eaeA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum)
PF14498
(Glyco_hyd_65N_2)
4 LEU A 779
TYR A 520
GLN A 512
GLU A 777
None
1.44A 6djzC-2eaeA:
undetectable
6djzC-2eaeA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyx PROTEIN DIPZ

(Mycobacterium
tuberculosis)
PF00578
(AhpC-TSA)
4 TRP A 508
TYR A 469
GLN A 441
GLU A 570
None
1.31A 6djzC-2hyxA:
2.6
6djzC-2hyxA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iss GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT


(Thermotoga
maritima)
PF01174
(SNO)
4 LEU D 179
ASP D  11
GLN D   9
GLU D 172
None
1.34A 6djzC-2issD:
undetectable
6djzC-2issD:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lpu KMATG10

(Kluyveromyces
marxianus)
PF03987
(Autophagy_act_C)
4 LEU A  17
TYR A   7
ASP A  29
GLN A  31
None
1.29A 6djzC-2lpuA:
undetectable
6djzC-2lpuA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otd GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE


(Shigella
flexneri)
PF03009
(GDPD)
4 LEU A 153
TYR A 213
ASP A  41
GLU A 114
None
PO4  A 301 (-4.0A)
PO4  A 301 (-3.8A)
PO4  A 301 (-3.4A)
0.95A 6djzC-2otdA:
undetectable
6djzC-2otdA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oz8 MLL7089 PROTEIN

(Mesorhizobium
japonicum)
PF13378
(MR_MLE_C)
4 LEU A 268
TYR A 134
ASP A 194
GLU A 222
None
1.48A 6djzC-2oz8A:
undetectable
6djzC-2oz8A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST


(Vitis vinifera)
PF00264
(Tyrosinase)
PF12142
(PPO1_DWL)
4 LEU A 131
TYR A 122
GLN A  37
GLU A 308
None
1.34A 6djzC-2p3xA:
undetectable
6djzC-2p3xA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p76 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE


(Staphylococcus
aureus)
PF03009
(GDPD)
4 LEU A 213
TYR A 277
ASP A  89
GLU A 169
None
GOL  A 501 ( 4.2A)
NA  A 401 (-2.6A)
NA  A 401 ( 3.0A)
1.13A 6djzC-2p76A:
undetectable
6djzC-2p76A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjj MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME


(Novosphingobium
aromaticivorans)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 TRP A 402
LEU A 317
ASP A 237
GLU A 262
None
None
MG  A1001 ( 4.6A)
MG  A1001 (-2.5A)
1.45A 6djzC-2qjjA:
undetectable
6djzC-2qjjA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qry THIAMINE-BINDING
PERIPLASMIC PROTEIN


(Escherichia
coli)
PF13343
(SBP_bac_6)
4 LEU A  86
TYR A 215
ASP A 121
GLU A 245
None
TPS  A 400 (-4.3A)
None
TPS  A 400 (-3.3A)
1.45A 6djzC-2qryA:
undetectable
6djzC-2qryA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vx4 CELLVIBRIO JAPONICUS
MANNANASE CJMAN26C


(Cellvibrio
japonicus)
PF02156
(Glyco_hydro_26)
4 LEU A 186
TYR A 261
ASP A 252
GLN A  60
None
1.47A 6djzC-2vx4A:
undetectable
6djzC-2vx4A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiv BETA-GLUCOSIDASE

(Secale cereale)
PF00232
(Glyco_hydro_1)
4 TRP A 106
LEU A 236
TYR A 156
GLN A 150
None
1.28A 6djzC-3aivA:
undetectable
6djzC-3aivA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens)
PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N)
4 LEU A  87
TYR A 263
GLN A 117
GLU A  90
None
1.25A 6djzC-3cttA:
1.3
6djzC-3cttA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqa GLUCOAMYLASE

(Aspergillus
niger)
PF00723
(Glyco_hydro_15)
4 LEU A 446
ASP A 354
GLN A 292
GLU A 350
None
1.47A 6djzC-3eqaA:
undetectable
6djzC-3eqaA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN


([Eubacterium]
rectale)
PF13614
(AAA_31)
4 LEU A 290
TYR A 225
GLN A 163
GLU A 253
None
1.50A 6djzC-3fkqA:
undetectable
6djzC-3fkqA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxg RHAMNONATE
DEHYDRATASE


(Fusarium
graminearum)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 LEU A 291
TYR A 166
ASP A 221
GLU A 247
None
None
MG  A 501 (-2.8A)
MG  A 501 (-3.2A)
1.49A 6djzC-3fxgA:
undetectable
6djzC-3fxgA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gkb PUTATIVE ENOYL-COA
HYDRATASE


(Streptomyces
avermitilis)
PF00378
(ECH_1)
4 TRP A 186
LEU A 268
GLN A 155
GLU A 142
None
1.38A 6djzC-3gkbA:
undetectable
6djzC-3gkbA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gku PROBABLE RNA-BINDING
PROTEIN


([Clostridium]
symbiosum)
PF01424
(R3H)
PF13083
(KH_4)
PF14804
(Jag_N)
4 LEU A 167
TYR A 139
GLN A 115
GLU A 174
None
1.39A 6djzC-3gkuA:
undetectable
6djzC-3gkuA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnr OS03G0212800 PROTEIN

(Oryza sativa)
PF00232
(Glyco_hydro_1)
4 TRP A  93
LEU A 223
TYR A 143
GLN A 137
TRP  A  93 ( 0.5A)
LEU  A 223 ( 0.5A)
TYR  A 143 ( 1.3A)
GLN  A 137 ( 0.6A)
1.39A 6djzC-3gnrA:
undetectable
6djzC-3gnrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4y CATECHOL
1,2-DIOXYGENASE


(Rhodococcus
opacus)
PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N)
4 TRP A 154
LEU A  91
ASP A  80
GLU A  84
None
1.31A 6djzC-3i4yA:
undetectable
6djzC-3i4yA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr1 PUTATIVE
FRUCTOSAMINE-3-KINAS
E


(Histophilus
somni)
PF03881
(Fructosamin_kin)
4 LEU A 251
TYR A 240
ASP A 218
GLU A 220
None
1.36A 6djzC-3jr1A:
undetectable
6djzC-3jr1A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC


(Escherichia
coli)
no annotation 4 LEU A 455
TYR A 374
ASP A 225
GLN A 303
None
1.08A 6djzC-3ly9A:
undetectable
6djzC-3ly9A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzn GLUCARATE
DEHYDRATASE


(Chromohalobacter
salexigens)
PF13378
(MR_MLE_C)
4 TRP A 170
LEU A 149
ASP A  17
GLN A 371
None
1.45A 6djzC-3mznA:
undetectable
6djzC-3mznA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3t PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE


(Thiobacillus
denitrificans)
PF00563
(EAL)
4 LEU A 613
ASP A 646
GLN A 670
GLU A 616
None
MG  A 802 (-2.7A)
C2E  A 801 (-3.3A)
MG  A 802 (-3.2A)
1.37A 6djzC-3n3tA:
undetectable
6djzC-3n3tA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ptk BETA-GLUCOSIDASE
OS4BGLU12


(Oryza sativa)
PF00232
(Glyco_hydro_1)
4 TRP A  92
LEU A 224
TYR A 144
GLN A 138
None
1.32A 6djzC-3ptkA:
undetectable
6djzC-3ptkA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsv MOTHERS AGAINST
DECAPENTAPLEGIC
HOMOLOG 4


(Mus musculus)
PF03165
(MH1)
4 LEU A  43
TYR A 117
ASP A  52
GLU A  53
None
1.24A 6djzC-3qsvA:
undetectable
6djzC-3qsvA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxf ENDOGLUCANASE

(Escherichia
coli)
PF01270
(Glyco_hydro_8)
4 TRP A 221
LEU A  97
ASP A 116
GLU A  55
None
1.19A 6djzC-3qxfA:
undetectable
6djzC-3qxfA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thu MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN


(Sphingomonas
sp. SKA58)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 TRP A 403
LEU A 318
ASP A 238
GLU A 263
None
None
MG  A 500 ( 4.5A)
MG  A 500 ( 2.6A)
1.48A 6djzC-3thuA:
undetectable
6djzC-3thuA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE


(Rauvolfia
serpentina)
PF00232
(Glyco_hydro_1)
4 TRP A  99
LEU A 248
TYR A 151
GLN A 145
None
1.28A 6djzC-3u5uA:
undetectable
6djzC-3u5uA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ucq AMYLOSUCRASE

(Deinococcus
geothermalis)
PF00128
(Alpha-amylase)
4 LEU A 334
ASP A 284
GLN A 252
GLU A 326
None
GOL  A 720 (-3.0A)
GOL  A 720 ( 4.4A)
TRS  A 700 (-4.2A)
1.34A 6djzC-3ucqA:
3.0
6djzC-3ucqA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4b STARVATION SENSING
PROTEIN RSPA


(Cellvibrio
japonicus)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 TRP A 402
LEU A 317
ASP A 237
GLU A 262
None
None
MG  A 403 ( 4.6A)
MG  A 403 ( 2.5A)
1.46A 6djzC-3v4bA:
undetectable
6djzC-3v4bA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcn MANNONATE
DEHYDRATASE


(Caulobacter
vibrioides)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 TRP A 403
LEU A 318
ASP A 238
GLU A 263
None
None
MG  A 501 ( 4.6A)
MG  A 501 (-2.5A)
1.50A 6djzC-3vcnA:
undetectable
6djzC-3vcnA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wau 4-O-BETA-D-MANNOSYL-
D-GLUCOSE
PHOSPHORYLASE


(Bacteroides
fragilis)
PF04041
(Glyco_hydro_130)
4 TRP A 225
LEU A 269
GLN A 190
GLU A 257
None
1.25A 6djzC-3wauA:
undetectable
6djzC-3wauA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1


(Homo sapiens)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 LEU A 326
TYR A 194
ASP A 254
GLU A 280
None
None
MG  A1445 (-2.6A)
MG  A1445 (-3.0A)
1.48A 6djzC-4a35A:
undetectable
6djzC-4a35A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B


(Cellvibrio
japonicus)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110)
4 LEU A 300
TYR A 189
ASP A 509
GLN A 491
None
1.39A 6djzC-4b9yA:
undetectable
6djzC-4b9yA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bla MALTOSE-BINDING
PERIPLASMIC PROTEIN,
SUPPRESSOR OF FUSED
HOMOLOG


(Escherichia
coli;
Homo sapiens)
PF05076
(SUFU)
PF12470
(SUFU_C)
PF13416
(SBP_bac_8)
4 LEU A 464
TYR A 385
ASP A 522
GLN A 526
None
1.41A 6djzC-4blaA:
undetectable
6djzC-4blaA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1


(Homo sapiens)
PF03372
(Exo_endo_phos)
4 LEU A 376
TYR A 513
ASP A 451
GLN A 445
None
1.50A 6djzC-4cmnA:
undetectable
6djzC-4cmnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csq UNCHARACTERIZED
PROTEIN


(Pseudomonas
aeruginosa)
no annotation 4 LEU A 103
ASP A  12
GLN A   7
GLU A  13
None
1.44A 6djzC-4csqA:
undetectable
6djzC-4csqA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4f MANNONATE
DEHYDRATASE


(Pectobacterium
carotovorum)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 TRP A 404
LEU A 319
ASP A 239
GLU A 264
None
None
MG  A 504 (-4.0A)
MG  A 504 ( 2.5A)
1.49A 6djzC-4e4fA:
undetectable
6djzC-4e4fA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE


(Homo sapiens)
PF00884
(Sulfatase)
PF14707
(Sulfatase_C)
4 TRP A 141
LEU A 128
GLN A 148
GLU A 126
None
1.41A 6djzC-4fdjA:
undetectable
6djzC-4fdjA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fi4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Caulobacter sp.
K31)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 TRP A 403
LEU A 318
ASP A 238
GLU A 263
None
None
MG  A 501 ( 4.5A)
MG  A 501 ( 2.5A)
1.49A 6djzC-4fi4A:
undetectable
6djzC-4fi4A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN


(Pseudomonas)
PF01804
(Penicil_amidase)
4 TRP A 149
LEU A 161
TYR A 121
GLN A  62
None
1.47A 6djzC-4hstA:
undetectable
6djzC-4hstA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyq PHOSPHOLIPASE A1

(Streptomyces
albidoflavus)
PF13472
(Lipase_GDSL_2)
4 LEU A 205
TYR A  35
ASP A  10
GLN A  65
None
1.50A 6djzC-4hyqA:
undetectable
6djzC-4hyqA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ip4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN


(Ruegeria sp.
TM1040)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 LEU A 316
TYR A 186
ASP A 246
GLU A 272
None
None
MG  A 503 (-2.6A)
MG  A 503 (-2.9A)
1.40A 6djzC-4ip4A:
undetectable
6djzC-4ip4A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
PF00105
(zf-C4)
4 LEU A 329
TYR A 319
ASP A 273
GLU A 276
None
1.24A 6djzC-4iqrA:
undetectable
6djzC-4iqrA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j91 KTR SYSTEM POTASSIUM
UPTAKE PROTEIN A


(Bacillus
subtilis)
PF02080
(TrkA_C)
PF02254
(TrkA_N)
4 LEU A 162
ASP A 138
GLN A 134
GLU A 218
None
1.13A 6djzC-4j91A:
undetectable
6djzC-4j91A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc2 ASFP504

(Alcyonium)
PF01353
(GFP)
4 LEU A 219
TYR A  71
ASP A  74
GLN A 184
None
1.34A 6djzC-4jc2A:
undetectable
6djzC-4jc2A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kws D-MANNONATE
DEHYDRATASE


(Chromohalobacter
salexigens)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 TRP A 405
LEU A 320
ASP A 240
GLU A 265
None
None
MG  A 501 ( 4.7A)
MG  A 501 ( 2.5A)
1.48A 6djzC-4kwsA:
undetectable
6djzC-4kwsA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kws D-MANNONATE
DEHYDRATASE


(Chromohalobacter
salexigens)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 TRP A 405
LEU A 320
TYR A 171
ASP A 213
None
None
None
MG  A 501 (-2.6A)
1.43A 6djzC-4kwsA:
undetectable
6djzC-4kwsA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7z HPCH/HPAI ALDOLASE

(Chloroflexus
aurantiacus)
PF03328
(HpcH_HpaI)
4 TRP A 272
LEU A  96
ASP A  61
GLU A  60
None
1.49A 6djzC-4l7zA:
undetectable
6djzC-4l7zA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
RAS-RELATED PROTEIN
RAP-1B


(Mus musculus;
Homo sapiens)
PF00027
(cNMP_binding)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00071
(Ras)
4 LEU E 893
ASP R  38
GLN R  43
GLU R  37
None
1.25A 6djzC-4mh0E:
1.6
6djzC-4mh0E:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nex ACETYLGLUTAMATE
KINASE


(Xylella
fastidiosa)
PF04768
(NAT)
4 TRP A 409
LEU A 319
TYR A 352
GLN A 431
None
0.93A 6djzC-4nexA:
undetectable
6djzC-4nexA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzr PROTEIN M TD

(Mycoplasma
genitalium)
no annotation 4 LEU M 169
TYR M 293
ASP M 339
GLU M 313
None
GOL  M 501 ( 2.8A)
None
None
1.42A 6djzC-4nzrM:
undetectable
6djzC-4nzrM:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Actinobacillus
succinogenes)
PF03480
(DctP)
4 LEU A  95
TYR A 147
GLN A  36
GLU A  73
None
2Q2  A 403 (-4.1A)
None
2Q2  A 403 (-2.8A)
1.50A 6djzC-4o8mA:
undetectable
6djzC-4o8mA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovj EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1


(Alicyclobacillus
acidocaldarius)
PF13416
(SBP_bac_8)
4 LEU A 298
ASP A 205
GLN A 415
GLU A 280
None
1.27A 6djzC-4ovjA:
undetectable
6djzC-4ovjA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE


(Bacillus
anthracis)
PF03009
(GDPD)
4 LEU A 195
TYR A 280
ASP A  72
GLU A 152
None
GOL  A 405 (-3.6A)
MG  A 401 (-3.0A)
MG  A 401 ( 3.1A)
1.16A 6djzC-4r7oA:
undetectable
6djzC-4r7oA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)


(Clostridium
acetobutylicum)
PF07470
(Glyco_hydro_88)
4 TRP A 204
LEU A  19
GLN A 250
GLU A 344
None
1.49A 6djzC-4wu0A:
undetectable
6djzC-4wu0A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmv AMINOPEPTIDASE N

(Escherichia
coli)
PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C)
4 LEU A 731
TYR A 660
ASP A 712
GLN A 665
None
None
GOL  A 913 (-3.4A)
None
1.44A 6djzC-4xmvA:
undetectable
6djzC-4xmvA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwt DR2417

(Deinococcus
radiodurans)
PF00753
(Lactamase_B)
PF07521
(RMMBL)
4 LEU A  93
TYR A 276
GLN A 316
GLU A  87
None
1.46A 6djzC-4xwtA:
undetectable
6djzC-4xwtA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ygs HYDROLASE

(Thermococcus
onnurineus)
PF13419
(HAD_2)
4 LEU A  23
TYR A 114
ASP A   9
GLU A  15
None
1.42A 6djzC-4ygsA:
undetectable
6djzC-4ygsA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0z AURONE SYNTHASE

(Coreopsis
grandiflora)
PF00264
(Tyrosinase)
PF12142
(PPO1_DWL)
4 LEU A 139
TYR A 130
GLN A  44
GLU A 322
None
1.46A 6djzC-4z0zA:
undetectable
6djzC-4z0zA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE


(Geobacillus
stearothermophilus)
PF00232
(Glyco_hydro_1)
4 TRP A  85
LEU A 203
TYR A 135
GLN A 129
None
1.29A 6djzC-4zfmA:
undetectable
6djzC-4zfmA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgv FERREDOXIN RECEPTOR

(Pectobacterium
atrosepticum)
PF07715
(Plug)
4 LEU A 600
TYR A 459
GLN A 478
GLU A 586
None
1.26A 6djzC-4zgvA:
undetectable
6djzC-4zgvA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA


(Methanothermobacter
marburgensis;
Methanothermobacter
marburgensis)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
4 LEU A 468
TYR B 190
ASP B 228
GLN B 220
None
1.41A 6djzC-5a8rA:
undetectable
6djzC-5a8rA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd6 TPR-DOMAIN
CONTAINING PROTEIN


(Parabacteroides
distasonis)
PF17128
(DUF5107)
4 LEU A 488
TYR A 428
ASP A 399
GLU A 398
None
1.41A 6djzC-5cd6A:
1.0
6djzC-5cd6A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE


(Bacillus
subtilis)
PF00698
(Acyl_transf_1)
4 LEU A 234
TYR A  62
ASP A 101
GLN A  30
None
1.45A 6djzC-5dz7A:
undetectable
6djzC-5dz7A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE


(Rhodobacter
sphaeroides)
PF00535
(Glycos_transf_2)
PF03552
(Cellulose_synt)
PF07238
(PilZ)
4 LEU A 205
ASP A 248
GLN A 379
GLU A 151
None
1.38A 6djzC-5ej1A:
undetectable
6djzC-5ej1A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fpw PRO CATHEPSIN B S9

(Trypanosoma
congolense)
PF00112
(Peptidase_C1)
4 TRP A  27
LEU A 256
ASP A 252
GLN A  21
None
1.48A 6djzC-5fpwA:
undetectable
6djzC-5fpwA:
18.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hk2 SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1


(Homo sapiens)
PF04622
(ERG2_Sigma1R)
6 TRP A  89
LEU A  95
TYR A 120
ASP A 126
GLN A 135
GLU A 172
None
None
None
61V  A 301 (-3.2A)
None
61V  A 301 (-2.9A)
0.34A 6djzC-5hk2A:
34.1
6djzC-5hk2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5in8 ARISTOLOCHENE
SYNTHASE


(Aspergillus
terreus)
no annotation 4 LEU A 178
TYR A 168
ASP A 214
GLN A 240
None
1.45A 6djzC-5in8A:
0.6
6djzC-5in8A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j98 VP3

(Slow bee
paralysis virus)
PF00073
(Rhv)
4 LEU C 367
TYR C 110
ASP C 416
GLU C 372
None
1.33A 6djzC-5j98C:
undetectable
6djzC-5j98C:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK


(Streptomyces
peucetius)
PF00891
(Methyltransf_2)
4 LEU A 302
TYR A 342
ASP A 287
GLN A 334
None
4MU  A 402 ( 4.6A)
None
None
1.38A 6djzC-5jr3A:
undetectable
6djzC-5jr3A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 UNCHARACTERIZED
PROTEIN
N-TERMINAL
ACETYLTRANSFERASE B
COMPLEX SUBUNIT NAT3


(Candida
albicans;
Candida
albicans)
PF09797
(NatB_MDM20)
PF08445
(FR47)
4 LEU B 123
TYR B  57
ASP B  21
GLN A 436
COA  B 202 (-2.9A)
None
COA  B 202 ( 4.0A)
None
1.34A 6djzC-5k04B:
undetectable
6djzC-5k04B:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkg DIGUANYLATE
PHOSPHODIESTERASE


(Pseudomonas
aeruginosa)
PF00563
(EAL)
4 LEU B 127
ASP B 160
GLN B 184
GLU B 130
None
CA  B 302 (-2.5A)
C2E  B 304 (-3.1A)
CA  B 302 (-3.3A)
1.38A 6djzC-5mkgB:
undetectable
6djzC-5mkgB:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)


(Plasmodium
falciparum)
PF05424
(Duffy_binding)
4 LEU A 932
ASP A 922
GLN A 822
GLU A 925
None
1.26A 6djzC-5mzaA:
undetectable
6djzC-5mzaA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogs WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1


(Homo sapiens)
no annotation 4 LEU A 440
ASP A 534
GLN A 531
GLU A 502
None
1.49A 6djzC-5ogsA:
undetectable
6djzC-5ogsA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt 40S RIBOSOMAL
PROTEIN S12
40S RIBOSOMAL
PROTEIN S10,
PUTATIVE


(Trypanosoma
cruzi;
Trypanosoma
cruzi)
no annotation
no annotation
4 LEU i  43
TYR n  86
ASP n  11
GLN n  48
None
None
U  E1725 ( 3.6A)
None
1.40A 6djzC-5opti:
undetectable
6djzC-5opti:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqp CONDENSIN COMPLEX
SUBUNIT 3


(Saccharomyces
cerevisiae)
no annotation 4 LEU A 724
ASP A 771
GLN A 841
GLU A 726
None
1.43A 6djzC-5oqpA:
undetectable
6djzC-5oqpA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN


(Chaetomium
thermophilum)
PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C)
4 LEU A 501
ASP A 583
GLN A 447
GLU A 508
None
1.44A 6djzC-5t8vA:
undetectable
6djzC-5t8vA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9c GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE


(Bacillus
subtilis)
PF03009
(GDPD)
4 LEU E 195
TYR E 259
ASP E  72
GLU E 152
None
G3P  E 302 (-3.8A)
CA  E 301 ( 2.9A)
CA  E 301 ( 3.2A)
1.13A 6djzC-5t9cE:
undetectable
6djzC-5t9cE:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s DNA REPLICATION
LICENSING FACTOR
MCM4


(Saccharomyces
cerevisiae)
PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB)
4 LEU 4 544
TYR 4 706
ASP 4 703
GLN 4 797
None
1.18A 6djzC-5u8s4:
undetectable
6djzC-5u8s4:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1


(Saccharomyces
cerevisiae)
no annotation 4 TRP C1158
TYR C1297
GLN C1151
GLU C1140
None
1.48A 6djzC-5x6oC:
undetectable
6djzC-5x6oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4k DMSP LYASE DDDY

(Acinetobacter
bereziniae)
no annotation 4 TRP A 315
LEU A 355
TYR A 262
GLN A 294
None
1.41A 6djzC-5y4kA:
4.8
6djzC-5y4kA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdf TRNA
(CYTOSINE(38)-C(5))-
METHYLTRANSFERASE


(Schizosaccharomyces
pombe)
no annotation 4 TRP A 294
LEU A 285
TYR A 211
GLU A 203
None
1.27A 6djzC-6fdfA:
undetectable
6djzC-6fdfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frv GLUCOAMYLASE

(Aspergillus
niger)
no annotation 4 LEU A 446
ASP A 354
GLN A 292
GLU A 350
None
1.48A 6djzC-6frvA:
undetectable
6djzC-6frvA:
undetectable