SIMILAR PATTERNS OF AMINO ACIDS FOR 6DJZ_C_GMJC301
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bjw | ASPARTATEAMINOTRANSFERASE (Thermusthermophilus) |
PF00155(Aminotran_1_2) | 5 | ALA A 235PHE A 354VAL A 126VAL A 349ALA A 365 | LLP A 234 ( 3.7A)NoneNoneNoneNone | 1.05A | 6djzC-1bjwA:0.0 | 6djzC-1bjwA:23.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c3r | HDLP (HISTONEDEACETYLASE-LIKEPROTEIN) (Aquifexaeolicus) |
PF00850(Hist_deacetyl) | 5 | ALA A 169LEU A 167PHE A 286LEU A 222ALA A 234 | ZN A 501 ( 4.9A)NoneNoneNoneNone | 1.11A | 6djzC-1c3rA:0.0 | 6djzC-1c3rA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g8x | MYOSIN II HEAVYCHAIN FUSED TOALPHA-ACTININ 3 (Dictyosteliumdiscoideum) |
PF00063(Myosin_head)PF00435(Spectrin)PF02736(Myosin_N) | 5 | MET A 342SER A 379VAL A 384LEU A 298ALA A 349 | None | 1.11A | 6djzC-1g8xA:0.0 | 6djzC-1g8xA:11.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hg0 | L-ASPARAGINASE (Dickeyachrysanthemi) |
PF00710(Asparaginase) | 5 | ALA A 42PHE A 177VAL A 154HIS A 93LEU A 34 | None | 1.05A | 6djzC-1hg0A:0.0 | 6djzC-1hg0A:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i7q | ANTHRANILATESYNTHASE (Serratiamarcescens) |
PF00425(Chorismate_bind)PF04715(Anth_synt_I_N) | 5 | ALA A 458LEU A 8VAL A 13LEU A 177ALA A 58 | None | 1.11A | 6djzC-1i7qA:0.0 | 6djzC-1i7qA:18.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jqb | NADP-DEPENDENTALCOHOLDEHYDROGENASE (Clostridiumbeijerinckii) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | MET A1140ALA A1134LEU A1136VAL A1323THR A1149 | None | 1.15A | 6djzC-1jqbA:0.0 | 6djzC-1jqbA:22.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jx2 | MYOSIN-2 HEAVYCHAIN,DYNAMIN-A (Dictyosteliumdiscoideum) |
PF00063(Myosin_head)PF02736(Myosin_N) | 5 | MET A 353SER A 390VAL A 395LEU A 309ALA A 360 | None | 1.16A | 6djzC-1jx2A:0.9 | 6djzC-1jx2A:11.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m7j | D-AMINOACYLASE (Alcaligenesfaecalis) |
PF07969(Amidohydro_3) | 6 | SER A 249PHE A 413VAL A 92HIS A 67VAL A 247TYR A 389 | NoneNoneNone ZN A 802 ( 3.2A)NoneNone | 1.10A | 6djzC-1m7jA:undetectable | 6djzC-1m7jA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p88 | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Escherichiacoli) |
PF00275(EPSP_synthase) | 5 | ALA A 59LEU A 57VAL A 239LEU A 92ALA A 98 | None | 0.99A | 6djzC-1p88A:0.0 | 6djzC-1p88A:23.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qpo | QUINOLINATE ACIDPHOSPHORIBOSYLTRANSFERASE (Mycobacteriumtuberculosis) |
PF01729(QRPTase_C)PF02749(QRPTase_N) | 5 | LEU A 45VAL A 278THR A 62ALA A 103TYR A 72 | None | 1.17A | 6djzC-1qpoA:undetectable | 6djzC-1qpoA:24.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1re5 | 3-CARBOXY-CIS,CIS-MUCONATECYCLOISOMERASE (Pseudomonasputida) |
PF00206(Lyase_1)PF10397(ADSL_C) | 5 | SER A 246HIS A 176VAL A 169LEU A 333ALA A 294 | None | 1.04A | 6djzC-1re5A:undetectable | 6djzC-1re5A:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wwl | MONOCYTEDIFFERENTIATIONANTIGEN CD14 (Mus musculus) |
no annotation | 5 | ALA A 80LEU A 40PHE A 30LEU A 87ALA A 90 | None | 1.07A | 6djzC-1wwlA:undetectable | 6djzC-1wwlA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ytl | ACETYL-COADECARBOXYLASE/SYNTHASE COMPLEX EPSILONSUBUNIT 2 (Archaeoglobusfulgidus) |
PF02552(CO_dh) | 5 | LEU A 88PHE A 74VAL A 83VAL A 54LEU A 126 | None | 1.13A | 6djzC-1ytlA:undetectable | 6djzC-1ytlA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2coc | FYVE, RHOGEF AND PHDOMAIN CONTAININGPROTEIN 3 (Homo sapiens) |
no annotation | 5 | ALA A 28SER A 111THR A 100LEU A 101ALA A 104 | None | 1.11A | 6djzC-2cocA:undetectable | 6djzC-2cocA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ctz | O-ACETYL-L-HOMOSERINE SULFHYDRYLASE (Thermusthermophilus) |
PF01053(Cys_Met_Meta_PP) | 5 | LEU A 67VAL A 179THR A 79LEU A 272ALA A 216 | None | 1.06A | 6djzC-2ctzA:undetectable | 6djzC-2ctzA:23.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cu0 | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Pyrococcushorikoshii) |
PF00478(IMPDH)PF00571(CBS) | 5 | ALA A 222LEU A 51VAL A 36THR A 41ALA A 290 | None | 1.15A | 6djzC-2cu0A:undetectable | 6djzC-2cu0A:18.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fk5 | FUCULOSE-1-PHOSPHATEALDOLASE (Thermusthermophilus) |
PF00596(Aldolase_II) | 5 | ALA A 161LEU A 5VAL A 57HIS A 74LEU A 167 | None | 1.15A | 6djzC-2fk5A:undetectable | 6djzC-2fk5A:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jk0 | L-ASPARAGINASE (Pectobacteriumcarotovorum) |
PF00710(Asparaginase) | 5 | ALA A 42PHE A 177VAL A 154HIS A 93LEU A 34 | None | 1.04A | 6djzC-2jk0A:undetectable | 6djzC-2jk0A:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nc8 | LIPOPROTEIN LPPM (Mycobacteriumtuberculosis) |
no annotation | 5 | ALA A 125LEU A 110PHE A 66VAL A 70ALA A 30 | None | 1.17A | 6djzC-2nc8A:undetectable | 6djzC-2nc8A:23.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o0x | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Mycobacteriumtuberculosis) |
PF00275(EPSP_synthase) | 5 | MET A 386ALA A 346VAL A 397LEU A 366ALA A 317 | None | 1.15A | 6djzC-2o0xA:undetectable | 6djzC-2o0xA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q6t | DNAB REPLICATIONFORK HELICASE (Thermusaquaticus) |
PF00772(DnaB)PF03796(DnaB_C) | 5 | LEU A 359VAL A 415THR A 219LEU A 218ALA A 221 | None | 1.17A | 6djzC-2q6tA:undetectable | 6djzC-2q6tA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qlt | (DL)-GLYCEROL-3-PHOSPHATASE 1 (Saccharomycescerevisiae) |
PF13419(HAD_2) | 5 | ALA A 126LEU A 124SER A 241VAL A 114VAL A 236 | None | 1.03A | 6djzC-2qltA:undetectable | 6djzC-2qltA:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qyg | RIBULOSEBISPHOSPHATECARBOXYLASE-LIKEPROTEIN 2 (Rhodopseudomonaspalustris) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 5 | ALA A 314LEU A 310PHE A 26HIS A 100VAL A 121 | None | 1.17A | 6djzC-2qygA:undetectable | 6djzC-2qygA:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ral | SERINE-ASPARTATEREPEAT-CONTAININGPROTEIN G (Staphylococcusepidermidis) |
PF10425(SdrG_C_C) | 5 | LEU A 497PHE A 530VAL A 488VAL A 467TYR A 424 | None | 1.09A | 6djzC-2ralA:2.3 | 6djzC-2ralA:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rgw | ASPARTATECARBAMOYLTRANSFERASE (Methanocaldococcusjannaschii) |
PF00185(OTCace)PF02729(OTCace_N) | 5 | ALA A 294LEU A 299VAL A 46THR A 133LEU A 136 | None | 1.16A | 6djzC-2rgwA:undetectable | 6djzC-2rgwA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rhq | PHENYLALANYL-TRNASYNTHETASE BETACHAIN (Staphylococcushaemolyticus) |
PF01588(tRNA_bind)PF03147(FDX-ACB)PF03483(B3_4)PF03484(B5) | 5 | ALA B 693LEU B 689PHE B 622LEU B 638ALA B 633 | None | 1.08A | 6djzC-2rhqB:undetectable | 6djzC-2rhqB:12.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vcy | TRANS-2-ENOYL-COAREDUCTASE (Homo sapiens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ALA A 206LEU A 340VAL A 152LEU A 175ALA A 171 | None | 1.07A | 6djzC-2vcyA:undetectable | 6djzC-2vcyA:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vn7 | GLUCOAMYLASE (Trichodermareesei) |
PF00686(CBM_20)PF00723(Glyco_hydro_15) | 5 | ALA A 195PHE A 470VAL A 154LEU A 130ALA A 56 | None | 1.13A | 6djzC-2vn7A:undetectable | 6djzC-2vn7A:18.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vro | ALDEHYDEDEHYDROGENASE (Paraburkholderiaxenovorans) |
PF00171(Aldedh) | 5 | ALA A 381LEU A 320PHE A 280VAL A 304ALA A 361 | None | 0.99A | 6djzC-2vroA:undetectable | 6djzC-2vroA:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vro | ALDEHYDEDEHYDROGENASE (Paraburkholderiaxenovorans) |
PF00171(Aldedh) | 5 | ALA A 381LEU A 320PHE A 280VAL A 304LEU A 360 | None | 1.15A | 6djzC-2vroA:undetectable | 6djzC-2vroA:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x1c | ACYL-COENZYME (Penicilliumchrysogenum) |
PF03417(AAT) | 5 | ALA A 211LEU A 224LEU A 185ALA A 188TYR A 166 | None | 1.11A | 6djzC-2x1cA:undetectable | 6djzC-2x1cA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ycb | CLEAVAGE ANDPOLYADENYLATIONSPECIFICITY FACTOR (Methanothermobacterthermautotrophicus) |
PF07521(RMMBL)PF10996(Beta-Casp)PF16661(Lactamase_B_6)PF17214(KH_7) | 5 | ALA A 237VAL A 633LEU A 322ALA A 336TYR A 264 | None | 1.16A | 6djzC-2ycbA:undetectable | 6djzC-2ycbA:14.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yev | CYTOCHROME C OXIDASEPOLYPEPTIDE I+III (Thermusthermophilus) |
PF00115(COX1)PF00510(COX3) | 5 | ALA A 754PHE A 589THR A 766LEU A 767ALA A 770 | NoneNone5PL A 900 (-2.8A)None5PL A 900 ( 4.3A) | 1.00A | 6djzC-2yevA:undetectable | 6djzC-2yevA:15.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a77 | INTERFERONREGULATORY FACTOR 3 (Homo sapiens) |
PF10401(IRF-3) | 5 | ALA A 283LEU A 281SER A 396VAL A 197LEU A 226 | None | 1.06A | 6djzC-3a77A:undetectable | 6djzC-3a77A:25.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3amj | ZINC PEPTIDASEINACTIVE SUBUNIT (Sphingomonassp. A1) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C) | 6 | ALA B 91LEU B 101PHE B 52HIS B 201THR B 78LEU B 85 | None | 1.50A | 6djzC-3amjB:undetectable | 6djzC-3amjB:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cnj | CHOLESTEROL OXIDASE (Streptomycessp. SA-COO) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | ALA A 441VAL A 482VAL A 124LEU A 375ALA A 363 | None | 1.09A | 6djzC-3cnjA:undetectable | 6djzC-3cnjA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cpx | AMINOPEPTIDASE, M42FAMILY (Cytophagahutchinsonii) |
PF05343(Peptidase_M42) | 5 | ALA A 180LEU A 257THR A 169ALA A 167TYR A 181 | EDO A 406 (-3.5A)NoneNoneNoneNone | 1.13A | 6djzC-3cpxA:undetectable | 6djzC-3cpxA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ddm | PUTATIVE MANDELATERACEMASE/MUCONATELACTONIZING ENZYME (Bordetellabronchiseptica) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | LEU A 374VAL A 45VAL A 73LEU A 344ALA A 40 | None | 1.11A | 6djzC-3ddmA:undetectable | 6djzC-3ddmA:17.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dfr | DIHYDROFOLATEREDUCTASE (Lactobacilluscasei) |
PF00186(DHFR_1) | 5 | ALA A 32VAL A 74VAL A 82LEU A 114ALA A 2 | None | 1.02A | 6djzC-3dfrA:undetectable | 6djzC-3dfrA:17.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fpl | NADP-DEPENDENTALCOHOLDEHYDROGENASE (Clostridiumbeijerinckii;Thermoanaerobacterbrockii) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | MET A 140ALA A 134LEU A 136VAL A 323THR A 149 | None | 1.08A | 6djzC-3fplA:undetectable | 6djzC-3fplA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hpa | AMIDOHYDROLASE (unidentified) |
PF01979(Amidohydro_1) | 5 | MET A 406VAL A 449THR A 387LEU A 388ALA A 391 | None | 1.12A | 6djzC-3hpaA:undetectable | 6djzC-3hpaA:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i99 | UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINEREDUCTASE (Vibrio cholerae) |
PF01565(FAD_binding_4)PF02873(MurB_C) | 5 | PHE A 340VAL A 338LEU A 280ALA A 277TYR A 330 | None | 1.17A | 6djzC-3i99A:undetectable | 6djzC-3i99A:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ive | NUCLEOTIDASE (Escherichiacoli) |
PF00149(Metallophos)PF02872(5_nucleotid_C) | 5 | ALA A 358LEU A 356PHE A 474LEU A 351TYR A 498 | None | 1.04A | 6djzC-3iveA:undetectable | 6djzC-3iveA:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k70 | EXODEOXYRIBONUCLEASEV BETA CHAIN (Escherichiacoli) |
PF00580(UvrD-helicase)PF12705(PDDEXK_1)PF13361(UvrD_C) | 5 | ALA B 124LEU B 60HIS B 130THR B 69LEU B 72 | None | 1.12A | 6djzC-3k70B:undetectable | 6djzC-3k70B:12.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3li9 | HYPOTHETICAL SENSORYTRANSDUCTIONHISTIDINE KINASE (Methanosarcinamazei) |
PF02743(dCache_1) | 5 | ALA A 69LEU A 106SER A 81THR A 75ALA A 77 | None | 1.18A | 6djzC-3li9A:undetectable | 6djzC-3li9A:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mnf | PAC2 FAMILY PROTEIN (Streptomycesavermitilis) |
PF09754(PAC2) | 5 | ALA A 25VAL A 231THR A 202LEU A 205ALA A 204 | None | 1.16A | 6djzC-3mnfA:undetectable | 6djzC-3mnfA:24.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mzn | GLUCARATEDEHYDRATASE (Chromohalobactersalexigens) |
PF13378(MR_MLE_C) | 5 | ALA A 82SER A 343HIS A 311LEU A 115ALA A 114 | None | 1.18A | 6djzC-3mznA:undetectable | 6djzC-3mznA:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mzn | GLUCARATEDEHYDRATASE (Chromohalobactersalexigens) |
PF13378(MR_MLE_C) | 5 | LEU A 60SER A 343HIS A 311LEU A 115ALA A 114 | None | 1.09A | 6djzC-3mznA:undetectable | 6djzC-3mznA:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pfo | PUTATIVEACETYLORNITHINEDEACETYLASE (Rhodopseudomonaspalustris) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | PHE A 55VAL A 171THR A 416LEU A 417ALA A 420 | None | 1.10A | 6djzC-3pfoA:undetectable | 6djzC-3pfoA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qv9 | PYRUVATE KINASE 2 (Trypanosomacruzi) |
PF00224(PK)PF02887(PK_C) | 5 | ALA A 72LEU A 38SER A 331VAL A 343LEU A 81 | NoneNonePO4 A 501 (-4.3A)NoneNone | 1.12A | 6djzC-3qv9A:undetectable | 6djzC-3qv9A:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rre | PUTATIVEUNCHARACTERIZEDPROTEIN (Thermotogamaritima) |
PF01256(Carb_kinase)PF03853(YjeF_N) | 5 | ALA A 339SER A 429HIS A 458THR A 364ALA A 343 | NoneADP A 493 (-3.2A)ADP A 493 (-4.4A)None MG A 492 ( 4.4A) | 1.08A | 6djzC-3rreA:undetectable | 6djzC-3rreA:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t5t | PUTATIVEGLYCOSYLTRANSFERASE (Streptomyceshygroscopicus) |
PF00982(Glyco_transf_20) | 5 | ALA A 28LEU A 30VAL A 45LEU A 84ALA A 52 | None | 0.96A | 6djzC-3t5tA:undetectable | 6djzC-3t5tA:17.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v64 | LOW-DENSITYLIPOPROTEINRECEPTOR-RELATEDPROTEIN 4 (Rattusnorvegicus) |
PF00058(Ldl_recept_b)PF14670(FXa_inhibition) | 5 | ALA C 625LEU C 627THR C 604LEU C 603ALA C 560 | None | 0.78A | 6djzC-3v64C:undetectable | 6djzC-3v64C:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v65 | LOW-DENSITYLIPOPROTEINRECEPTOR-RELATEDPROTEIN 4 (Rattusnorvegicus) |
PF00058(Ldl_recept_b)PF14670(FXa_inhibition) | 5 | ALA B 625LEU B 627THR B 604LEU B 603ALA B 560 | None | 0.81A | 6djzC-3v65B:undetectable | 6djzC-3v65B:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b3i | FATTY ACIDBETA-OXIDATIONCOMPLEX BETA-CHAINFADA (Mycobacteriumtuberculosis) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | ALA C 329LEU C 388VAL C 373VAL C 267LEU C 361 | None | 1.10A | 6djzC-4b3iC:undetectable | 6djzC-4b3iC:18.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bok | ALPHA-1,6-MANNANASE (Bacilluscirculans) |
PF03663(Glyco_hydro_76) | 5 | MET A 127ALA A 207HIS A 308LEU A 195ALA A 134 | None | 0.99A | 6djzC-4bokA:undetectable | 6djzC-4bokA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cvm | UDP-N-ACETYLMURAMOYL-TRIPEPTIDE--D-ALANYL-D- ALANINE LIGASE (Pseudomonasaeruginosa) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 5 | ALA A 105PHE A 269VAL A 290VAL A 280LEU A 124 | None | 1.12A | 6djzC-4cvmA:undetectable | 6djzC-4cvmA:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dn7 | ABC TRANSPORTER,ATP-BINDING PROTEIN (Methanosarcinamazei) |
PF01458(UPF0051) | 5 | ALA A 120SER A 35THR A 158LEU A 189ALA A 156 | None | 1.02A | 6djzC-4dn7A:undetectable | 6djzC-4dn7A:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dzt | AQUALYSIN-1 (Thermusaquaticus) |
PF00082(Peptidase_S8) | 5 | ALA A 93LEU A 91VAL A 231HIS A 227ALA A 207 | None | 1.01A | 6djzC-4dztA:undetectable | 6djzC-4dztA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f0q | RESTRICTIONENDONUCLEASE (Mycobacteriumsp. JLS) |
PF04471(Mrr_cat) | 5 | MET A 421ALA A 308PHE A 115THR A 413LEU A 414 | None | 1.07A | 6djzC-4f0qA:undetectable | 6djzC-4f0qA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hxq | ARGINASE-1 (Homo sapiens) |
PF00491(Arginase) | 6 | ALA A 34LEU A 37SER A 94VAL A 87THR A 300LEU A 301 | None | 1.33A | 6djzC-4hxqA:undetectable | 6djzC-4hxqA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l27 | CYSTATHIONINEBETA-SYNTHASE (Homo sapiens) |
no annotation | 5 | ALA B 158LEU B 154VAL B 314LEU B 136TYR B 163 | NoneNoneHEM B 602 (-4.1A)NoneNone | 1.12A | 6djzC-4l27B:undetectable | 6djzC-4l27B:18.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mkn | TRIOSEPHOSPHATEISOMERASE (Chlamydomonasreinhardtii) |
PF00121(TIM) | 5 | SER A 62PHE A 7VAL A 163VAL A 40THR A 84 | None | 0.85A | 6djzC-4mknA:undetectable | 6djzC-4mknA:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p6v | NA(+)-TRANSLOCATINGNADH-QUINONEREDUCTASE SUBUNIT B (Vibrio cholerae) |
PF03116(NQR2_RnfD_RnfE) | 5 | ALA B 235LEU B 249VAL B 275THR B 227ALA B 82 | None | 1.16A | 6djzC-4p6vB:undetectable | 6djzC-4p6vB:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r39 | BLUE-LIGHT-ACTIVATEDHISTIDINE KINASE 2 (Erythrobacterlitoralis) |
PF07568(HisKA_2)PF13581(HATPase_c_2) | 5 | LEU A 266VAL A 308THR A 249LEU A 252ALA A 251 | NoneNoneNoneNoneANP A 402 ( 4.1A) | 1.15A | 6djzC-4r39A:undetectable | 6djzC-4r39A:24.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rjk | ACETOLACTATESYNTHASE (Bacillussubtilis) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | LEU A 96PHE A 156VAL A 152VAL A 30ALA A 64 | None | 1.10A | 6djzC-4rjkA:undetectable | 6djzC-4rjkA:17.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rzi | 3-KETOACYL-ACYLCARRIER PROTEINREDUCTASE (Synechocystissp. PCC 6803) |
no annotation | 5 | ALA B 33LEU B 219VAL B 110LEU B 27ALA B 212 | None | 1.11A | 6djzC-4rziB:undetectable | 6djzC-4rziB:23.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u14 | MUSCARINICACETYLCHOLINERECEPTORM3,ENDOLYSIN,MUSCARINIC ACETYLCHOLINERECEPTOR M3 (Rattusnorvegicus;Escherichiavirus T4) |
PF00001(7tm_1)PF00959(Phage_lysozyme) | 5 | PHE A 105VAL A 160THR A 174LEU A 173ALA A 177 | None | 0.91A | 6djzC-4u14A:undetectable | 6djzC-4u14A:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v2i | ESTERASE/LIPASE (Thalassospirasp. GB04J01) |
PF07859(Abhydrolase_3) | 5 | ALA A 181LEU A 152VAL A 65VAL A 57ALA A 171 | None | 1.10A | 6djzC-4v2iA:undetectable | 6djzC-4v2iA:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgc | ORIGIN RECOGNITIONCOMPLEX SUBUNIT 2ORIGIN RECOGNITIONCOMPLEX SUBUNIT 5 (Drosophilamelanogaster;Drosophilamelanogaster) |
PF04084(ORC2)PF13191(AAA_16)PF14630(ORC5_C) | 5 | PHE E 418VAL E 411HIS E 412LEU B 451ALA B 447 | None | 1.14A | 6djzC-4xgcE:undetectable | 6djzC-4xgcE:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xq2 | CALE6 (Micromonosporaechinospora) |
PF01053(Cys_Met_Meta_PP) | 5 | LEU A 139VAL A 155THR A 103LEU A 106ALA A 80 | None | 1.17A | 6djzC-4xq2A:undetectable | 6djzC-4xq2A:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a4j | FORMATE--TETRAHYDROFOLATE LIGASE (Tepidanaerobacteracetatoxydans) |
PF01268(FTHFS) | 5 | ALA A 354LEU A 336VAL A 407LEU A 347ALA A 69 | None | 1.13A | 6djzC-5a4jA:undetectable | 6djzC-5a4jA:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b5x | LIMITINGCO2-INDUCIBLEPROTEIN LCIC (Chlamydomonasreinhardtii) |
no annotation | 5 | LEU A 343HIS A 297VAL A 127LEU A 82ALA A 88 | None | 1.14A | 6djzC-5b5xA:undetectable | 6djzC-5b5xA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5btx | LPG1496 (Legionellapneumophila) |
no annotation | 6 | PHE A 29VAL A 33VAL A 93THR A 108ALA A 77TYR A 61 | NoneNoneNoneCMP A 201 (-3.2A)NoneCMP A 201 (-3.6A) | 1.49A | 6djzC-5btxA:undetectable | 6djzC-5btxA:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dz6 | POLYKETIDEBIOSYNTHESIS MALONYLCOA-ACYL CARRIERPROTEIN TRANSACYLASEPKSC (Bacillussubtilis) |
PF00698(Acyl_transf_1) | 5 | SER A 87VAL A 159HIS A 193ALA A 84TYR A 254 | GOL A 301 (-3.6A)NoneGOL A 301 (-4.2A)NoneNone | 1.13A | 6djzC-5dz6A:undetectable | 6djzC-5dz6A:22.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5egi | UNCHARACTERIZEDPROTEIN Y57A10A.10 (Caenorhabditiselegans) |
PF05197(TRIC) | 5 | LEU A 80SER A 138HIS A 139LEU A 75ALA A 161 | NoneNoneNoneNonePT5 A 301 ( 4.2A) | 1.02A | 6djzC-5egiA:undetectable | 6djzC-5egiA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gve | DNA TOPOISOMERASE3-BETA-1 (Homo sapiens) |
PF01131(Topoisom_bac)PF01751(Toprim) | 5 | LEU A 301HIS A 387LEU A 328ALA A 325TYR A 409 | None | 1.09A | 6djzC-5gveA:undetectable | 6djzC-5gveA:16.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h2v | IMPORTIN SUBUNITBETA-3 (Saccharomycescerevisiae) |
PF13513(HEAT_EZ) | 5 | LEU A 364THR A 314LEU A 315ALA A 390TYR A 371 | None | 1.16A | 6djzC-5h2vA:undetectable | 6djzC-5h2vA:11.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5hk2 | SIGMA NON-OPIOIDINTRACELLULARRECEPTOR 1 (Homo sapiens) |
PF04622(ERG2_Sigma1R) | 9 | ALA A 98SER A 117PHE A 133VAL A 152HIS A 154VAL A 162THR A 181LEU A 182TYR A 206 | 61V A 301 ( 4.8A)61V A 301 (-2.9A)NoneNone61V A 301 ( 4.1A)None61V A 301 ( 4.7A)None61V A 301 (-3.6A) | 0.84A | 6djzC-5hk2A:34.1 | 6djzC-5hk2A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5hk2 | SIGMA NON-OPIOIDINTRACELLULARRECEPTOR 1 (Homo sapiens) |
PF04622(ERG2_Sigma1R) | 11 | MET A 93ALA A 98LEU A 105SER A 117PHE A 133VAL A 152HIS A 154VAL A 162THR A 181ALA A 185TYR A 206 | 61V A 301 (-3.4A)61V A 301 ( 4.8A)None61V A 301 (-2.9A)NoneNone61V A 301 ( 4.1A)None61V A 301 ( 4.7A)61V A 301 ( 4.2A)61V A 301 (-3.6A) | 0.51A | 6djzC-5hk2A:34.1 | 6djzC-5hk2A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5hk2 | SIGMA NON-OPIOIDINTRACELLULARRECEPTOR 1 (Homo sapiens) |
PF04622(ERG2_Sigma1R) | 9 | MET A 93ALA A 98LEU A 105SER A 117VAL A 153HIS A 154THR A 181ALA A 185TYR A 206 | 61V A 301 (-3.4A)61V A 301 ( 4.8A)None61V A 301 (-2.9A)None61V A 301 ( 4.1A)61V A 301 ( 4.7A)61V A 301 ( 4.2A)61V A 301 (-3.6A) | 1.45A | 6djzC-5hk2A:34.1 | 6djzC-5hk2A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ir6 | BD-TYPE QUINOLOXIDASE SUBUNIT I (Geobacillusstearothermophilus) |
PF01654(Cyt_bd_oxida_I) | 5 | ALA A 203LEU A 199VAL A 65VAL A 135ALA A 38 | NoneNoneHEB A 502 (-3.4A)NoneNone | 1.05A | 6djzC-5ir6A:undetectable | 6djzC-5ir6A:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jy1 | PUTATIVE SHORT-CHAINDEHYDROGENASE/REDUCTASE (Paraburkholderiaxenovorans) |
PF13561(adh_short_C2) | 5 | ALA A 125LEU A 84VAL A 228THR A 12ALA A 36 | ACT A 306 ( 4.1A)NoneNoneNoneNone | 1.14A | 6djzC-5jy1A:undetectable | 6djzC-5jy1A:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m77 | ALPHA-1,6-MANNANASE (Bacilluscirculans) |
PF03422(CBM_6)PF03663(Glyco_hydro_76) | 5 | MET A 127ALA A 207HIS A 308LEU A 195ALA A 134 | NoneNoneEDO A 605 ( 4.9A)NoneNone | 1.01A | 6djzC-5m77A:undetectable | 6djzC-5m77A:16.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nag | KYNURENINE3-MONOOXYGENASE (Pseudomonasfluorescens) |
PF01494(FAD_binding_3) | 5 | ALA A 177VAL A 10VAL A 22LEU A 297ALA A 313 | None | 0.94A | 6djzC-5nagA:undetectable | 6djzC-5nagA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nb3 | PHYCOERYTHRIN ALPHASUBUNIT,PHYCOERYTHRIN ALPHASUBUNIT,PHYCOERYTHRIN ALPHA SUBUNITPHYCOERYTHRIN BETASUBUNIT,PHYCOERYTHRIN BETA SUBUNIT (Phormidiumrubidum;Phormidiumrubidum) |
PF00502(Phycobilisome)PF00502(Phycobilisome) | 5 | ALA A 159LEU A 155SER M 6VAL A 4TYR A 89 | NoneNoneNoneNonePEB A 166 (-4.3A) | 1.07A | 6djzC-5nb3A:undetectable | 6djzC-5nb3A:23.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ngj | TAIL TUBE PROTEIN (Escherichiavirus T5) |
no annotation | 5 | LEU A 287SER A 264THR A 332LEU A 269TYR A 280 | None | 1.15A | 6djzC-5ngjA:undetectable | 6djzC-5ngjA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nug | CYTOPLASMIC DYNEIN 1HEAVY CHAIN 1 (Homo sapiens) |
PF03028(Dynein_heavy)PF07728(AAA_5)PF08393(DHC_N2)PF12774(AAA_6)PF12775(AAA_7)PF12777(MT)PF12780(AAA_8)PF12781(AAA_9) | 5 | ALA A3512THR A3153LEU A3154ALA A3157TYR A3516 | None | 1.07A | 6djzC-5nugA:undetectable | 6djzC-5nugA:3.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u1w | P2X PURINOCEPTOR (Ailuropodamelanoleuca) |
PF00864(P2X_receptor) | 5 | LEU A 278PHE A 102VAL A 104VAL A 190THR A 238 | None | 1.09A | 6djzC-5u1wA:undetectable | 6djzC-5u1wA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u4h | UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE (Acinetobacterbaumannii) |
PF00275(EPSP_synthase) | 5 | LEU A 195PHE A 159VAL A 157LEU A 222ALA A 175 | None | 1.05A | 6djzC-5u4hA:undetectable | 6djzC-5u4hA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wq3 | CYTOKININ RIBOSIDE5'-MONOPHOSPHATEPHOSPHORIBOHYDROLASE (Corynebacteriumglutamicum) |
PF03641(Lysine_decarbox) | 5 | LEU A 92PHE A 194VAL A 182LEU A 111TYR A 86 | None | 1.10A | 6djzC-5wq3A:undetectable | 6djzC-5wq3A:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wsl | KERATINASE (Meiothermustaiwanensis) |
no annotation | 5 | ALA A 95LEU A 93VAL A 233HIS A 229ALA A 209 | None | 0.92A | 6djzC-5wslA:undetectable | 6djzC-5wslA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x7u | TREHALOSE SYNTHASE (Thermobaculumterrenum) |
no annotation | 5 | ALA A 330LEU A 348HIS A 309LEU A 314TYR A 326 | None | 1.11A | 6djzC-5x7uA:undetectable | 6djzC-5x7uA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y3j | TOLL-LIKE RECEPTOR 9 (Equus caballus) |
no annotation | 5 | LEU A 640SER A 589HIS A 588VAL A 591ALA A 615 | None MG A1011 (-2.7A)NoneNoneNone | 1.09A | 6djzC-5y3jA:undetectable | 6djzC-5y3jA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ykb | TREHALOSE SYNTHASE (Deinococcusradiodurans) |
no annotation | 5 | ALA A 339LEU A 357HIS A 318LEU A 323TYR A 335 | None | 1.18A | 6djzC-5ykbA:undetectable | 6djzC-5ykbA:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yxg | PILUS ASSEMBLYPROTEIN (Lactobacillusrhamnosus) |
no annotation | 5 | PHE A 216VAL A 317VAL A 240THR A 322LEU A 210 | None | 1.13A | 6djzC-5yxgA:undetectable | 6djzC-5yxgA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cjb | CYSTATHIONINEBETA-LYASE (Legionellapneumophila) |
no annotation | 5 | LEU A 188PHE A 6THR A 146LEU A 144ALA A 173 | None | 1.11A | 6djzC-6cjbA:undetectable | 6djzC-6cjbA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dch | SCOE PROTEIN (Streptomycescoeruleorubidus) |
no annotation | 5 | ALA A 71LEU A 285VAL A 111VAL A 106LEU A 90 | None | 1.00A | 6djzC-6dchA:1.6 | 6djzC-6dchA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dd6 | PHOTOLYASE PHRB (Agrobacteriumtumefaciens) |
no annotation | 5 | LEU A 12PHE A 83VAL A 34VAL A 109TYR A 271 | NoneDLZ A 602 (-4.2A)DLZ A 602 (-4.6A)NoneNone | 1.12A | 6djzC-6dd6A:undetectable | 6djzC-6dd6A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6em0 | 2-HYDROXYBIPHENYL-3-MONOOXYGENASE (Pseudomonasnitroreducens) |
no annotation | 5 | ALA A 98PHE A 227VAL A 381VAL A 238TYR A 115 | None | 1.17A | 6djzC-6em0A:undetectable | 6djzC-6em0A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bev | BOVINE ENTEROVIRUSCOAT PROTEINS VP1 TOVP4BOVINE ENTEROVIRUSCOAT PROTEINS VP1 TOVP4 (Enterovirus E;Enterovirus E) |
PF00073(Rhv)PF00073(Rhv) | 4 | TRP 1 111LEU 3 94ASP 3 234GLN 1 104 | None | 1.43A | 6djzC-1bev1:0.6 | 6djzC-1bev1:24.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c7j | PROTEIN(PARA-NITROBENZYLESTERASE) (Bacillussubtilis) |
PF00135(COesterase) | 4 | LEU A 401TYR A 118GLN A 162GLU A 188 | None | 1.31A | 6djzC-1c7jA:undetectable | 6djzC-1c7jA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dwa | MYROSINASE MA1 (Sinapis alba) |
PF00232(Glyco_hydro_1) | 4 | TRP M 100LEU M 232TYR M 152GLN M 146 | NoneNoneNoneGOL M 933 (-3.4A) | 1.31A | 6djzC-1dwaM:undetectable | 6djzC-1dwaM:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e6v | METHYL-COENZYME MREDUCTASE I ALPHASUBUNITMETHYL-COENZYME MREDUCTASE I BETASUBUNIT (Methanopyruskandleri;Methanopyruskandleri) |
PF02249(MCR_alpha)PF02745(MCR_alpha_N)PF02241(MCR_beta)PF02783(MCR_beta_N) | 4 | LEU A 469TYR B 191ASP B 229GLN B 221 | None | 1.32A | 6djzC-1e6vA:undetectable | 6djzC-1e6vA:17.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hmd | HEMERYTHRIN (Themistedyscritum) |
no annotation | 4 | TRP A 97LEU A 56ASP A 106GLU A 58 | NoneNoneFEO A 115 (-2.6A)FEO A 115 (-2.5A) | 1.39A | 6djzC-1hmdA:undetectable | 6djzC-1hmdA:19.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j0h | NEOPULLULANASE (Geobacillusstearothermophilus) |
PF00128(Alpha-amylase)PF02903(Alpha-amylase_N)PF16657(Malt_amylase_C) | 4 | TRP A 160LEU A 175TYR A 457GLN A 482 | None | 1.21A | 6djzC-1j0hA:3.0 | 6djzC-1j0hA:16.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jf5 | ALPHA AMYLASE II (Thermoactinomycesvulgaris) |
PF00128(Alpha-amylase)PF02903(Alpha-amylase_N)PF16657(Malt_amylase_C) | 4 | TRP A 156LEU A 172TYR A 454GLN A 479 | None | 1.29A | 6djzC-1jf5A:2.3 | 6djzC-1jf5A:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kkr | 3-METHYLASPARTATEAMMONIA-LYASE (Citrobacteramalonaticus) |
PF05034(MAAL_N)PF07476(MAAL_C) | 4 | LEU A 245TYR A 74ASP A 238GLN A 172 | NoneNone MG A 501 ( 2.6A)2AS A 801 (-3.1A) | 1.20A | 6djzC-1kkrA:0.9 | 6djzC-1kkrA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qon | ACETYLCHOLINESTERASE (Drosophilamelanogaster) |
PF00135(COesterase) | 4 | LEU A 479TYR A 162GLN A 211GLU A 237 | NoneNoneNoneI40 A 997 (-4.2A) | 1.42A | 6djzC-1qonA:undetectable | 6djzC-1qonA:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t8q | GLYCEROPHOSPHORYLDIESTERPHOSPHODIESTERASE,PERIPLASMIC (Escherichiacoli) |
PF03009(GDPD) | 4 | LEU A 215TYR A 313ASP A 65GLU A 171 | NoneGOL A1605 (-3.8A) MG A1601 ( 2.7A) MG A1601 ( 2.9A) | 1.06A | 6djzC-1t8qA:undetectable | 6djzC-1t8qA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wyt | GLYCINEDEHYDROGENASE(DECARBOXYLATING)SUBUNIT 1 (Thermusthermophilus) |
PF02347(GDC-P) | 4 | LEU A 214TYR A 163ASP A 233GLN A 256 | None | 1.49A | 6djzC-1wytA:undetectable | 6djzC-1wytA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ddx | BETA-1,3-XYLANASE (Vibrio sp. AX-4) |
no annotation | 4 | LEU A 297TYR A 267ASP A 289GLN A 275 | None | 1.47A | 6djzC-2ddxA:undetectable | 6djzC-2ddxA:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e3z | BETA-GLUCOSIDASE (Phanerochaetechrysosporium) |
PF00232(Glyco_hydro_1) | 4 | TRP A 82LEU A 203TYR A 134GLN A 128 | None | 1.25A | 6djzC-2e3zA:undetectable | 6djzC-2e3zA:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eae | ALPHA-FUCOSIDASE (Bifidobacteriumbifidum) |
PF14498(Glyco_hyd_65N_2) | 4 | LEU A 534TYR A 520ASP A 689GLN A 781 | NoneNone CA A 902 (-2.9A)None | 1.49A | 6djzC-2eaeA:undetectable | 6djzC-2eaeA:14.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eae | ALPHA-FUCOSIDASE (Bifidobacteriumbifidum) |
PF14498(Glyco_hyd_65N_2) | 4 | LEU A 779TYR A 520GLN A 512GLU A 777 | None | 1.44A | 6djzC-2eaeA:undetectable | 6djzC-2eaeA:14.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hyx | PROTEIN DIPZ (Mycobacteriumtuberculosis) |
PF00578(AhpC-TSA) | 4 | TRP A 508TYR A 469GLN A 441GLU A 570 | None | 1.31A | 6djzC-2hyxA:2.6 | 6djzC-2hyxA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iss | GLUTAMINEAMIDOTRANSFERASESUBUNIT PDXT (Thermotogamaritima) |
PF01174(SNO) | 4 | LEU D 179ASP D 11GLN D 9GLU D 172 | None | 1.34A | 6djzC-2issD:undetectable | 6djzC-2issD:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lpu | KMATG10 (Kluyveromycesmarxianus) |
PF03987(Autophagy_act_C) | 4 | LEU A 17TYR A 7ASP A 29GLN A 31 | None | 1.29A | 6djzC-2lpuA:undetectable | 6djzC-2lpuA:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2otd | GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE (Shigellaflexneri) |
PF03009(GDPD) | 4 | LEU A 153TYR A 213ASP A 41GLU A 114 | NonePO4 A 301 (-4.0A)PO4 A 301 (-3.8A)PO4 A 301 (-3.4A) | 0.95A | 6djzC-2otdA:undetectable | 6djzC-2otdA:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oz8 | MLL7089 PROTEIN (Mesorhizobiumjaponicum) |
PF13378(MR_MLE_C) | 4 | LEU A 268TYR A 134ASP A 194GLU A 222 | None | 1.48A | 6djzC-2oz8A:undetectable | 6djzC-2oz8A:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p3x | POLYPHENOL OXIDASE,CHLOROPLAST (Vitis vinifera) |
PF00264(Tyrosinase)PF12142(PPO1_DWL) | 4 | LEU A 131TYR A 122GLN A 37GLU A 308 | None | 1.34A | 6djzC-2p3xA:undetectable | 6djzC-2p3xA:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p76 | GLYCEROPHOSPHORYLDIESTERPHOSPHODIESTERASE (Staphylococcusaureus) |
PF03009(GDPD) | 4 | LEU A 213TYR A 277ASP A 89GLU A 169 | NoneGOL A 501 ( 4.2A) NA A 401 (-2.6A) NA A 401 ( 3.0A) | 1.13A | 6djzC-2p76A:undetectable | 6djzC-2p76A:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qjj | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME (Novosphingobiumaromaticivorans) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | TRP A 402LEU A 317ASP A 237GLU A 262 | NoneNone MG A1001 ( 4.6A) MG A1001 (-2.5A) | 1.45A | 6djzC-2qjjA:undetectable | 6djzC-2qjjA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qry | THIAMINE-BINDINGPERIPLASMIC PROTEIN (Escherichiacoli) |
PF13343(SBP_bac_6) | 4 | LEU A 86TYR A 215ASP A 121GLU A 245 | NoneTPS A 400 (-4.3A)NoneTPS A 400 (-3.3A) | 1.45A | 6djzC-2qryA:undetectable | 6djzC-2qryA:19.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vx4 | CELLVIBRIO JAPONICUSMANNANASE CJMAN26C (Cellvibriojaponicus) |
PF02156(Glyco_hydro_26) | 4 | LEU A 186TYR A 261ASP A 252GLN A 60 | None | 1.47A | 6djzC-2vx4A:undetectable | 6djzC-2vx4A:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aiv | BETA-GLUCOSIDASE (Secale cereale) |
PF00232(Glyco_hydro_1) | 4 | TRP A 106LEU A 236TYR A 156GLN A 150 | None | 1.28A | 6djzC-3aivA:undetectable | 6djzC-3aivA:14.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ctt | MALTASE-GLUCOAMYLASE (Homo sapiens) |
PF00088(Trefoil)PF01055(Glyco_hydro_31)PF16863(NtCtMGAM_N) | 4 | LEU A 87TYR A 263GLN A 117GLU A 90 | None | 1.25A | 6djzC-3cttA:1.3 | 6djzC-3cttA:14.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eqa | GLUCOAMYLASE (Aspergillusniger) |
PF00723(Glyco_hydro_15) | 4 | LEU A 446ASP A 354GLN A 292GLU A 350 | None | 1.47A | 6djzC-3eqaA:undetectable | 6djzC-3eqaA:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fkq | NTRC-LIKE TWO-DOMAINPROTEIN ([Eubacterium]rectale) |
PF13614(AAA_31) | 4 | LEU A 290TYR A 225GLN A 163GLU A 253 | None | 1.50A | 6djzC-3fkqA:undetectable | 6djzC-3fkqA:18.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fxg | RHAMNONATEDEHYDRATASE (Fusariumgraminearum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | LEU A 291TYR A 166ASP A 221GLU A 247 | NoneNone MG A 501 (-2.8A) MG A 501 (-3.2A) | 1.49A | 6djzC-3fxgA:undetectable | 6djzC-3fxgA:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gkb | PUTATIVE ENOYL-COAHYDRATASE (Streptomycesavermitilis) |
PF00378(ECH_1) | 4 | TRP A 186LEU A 268GLN A 155GLU A 142 | None | 1.38A | 6djzC-3gkbA:undetectable | 6djzC-3gkbA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gku | PROBABLE RNA-BINDINGPROTEIN ([Clostridium]symbiosum) |
PF01424(R3H)PF13083(KH_4)PF14804(Jag_N) | 4 | LEU A 167TYR A 139GLN A 115GLU A 174 | None | 1.39A | 6djzC-3gkuA:undetectable | 6djzC-3gkuA:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gnr | OS03G0212800 PROTEIN (Oryza sativa) |
PF00232(Glyco_hydro_1) | 4 | TRP A 93LEU A 223TYR A 143GLN A 137 | TRP A 93 ( 0.5A)LEU A 223 ( 0.5A)TYR A 143 ( 1.3A)GLN A 137 ( 0.6A) | 1.39A | 6djzC-3gnrA:undetectable | 6djzC-3gnrA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i4y | CATECHOL1,2-DIOXYGENASE (Rhodococcusopacus) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 4 | TRP A 154LEU A 91ASP A 80GLU A 84 | None | 1.31A | 6djzC-3i4yA:undetectable | 6djzC-3i4yA:25.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jr1 | PUTATIVEFRUCTOSAMINE-3-KINASE (Histophilussomni) |
PF03881(Fructosamin_kin) | 4 | LEU A 251TYR A 240ASP A 218GLU A 220 | None | 1.36A | 6djzC-3jr1A:undetectable | 6djzC-3jr1A:18.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ly9 | TRANSCRIPTIONALACTIVATOR CADC (Escherichiacoli) |
no annotation | 4 | LEU A 455TYR A 374ASP A 225GLN A 303 | None | 1.08A | 6djzC-3ly9A:undetectable | 6djzC-3ly9A:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mzn | GLUCARATEDEHYDRATASE (Chromohalobactersalexigens) |
PF13378(MR_MLE_C) | 4 | TRP A 170LEU A 149ASP A 17GLN A 371 | None | 1.45A | 6djzC-3mznA:undetectable | 6djzC-3mznA:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n3t | PUTATIVE DIGUANYLATECYCLASE/PHOSPHODIESTERASE (Thiobacillusdenitrificans) |
PF00563(EAL) | 4 | LEU A 613ASP A 646GLN A 670GLU A 616 | None MG A 802 (-2.7A)C2E A 801 (-3.3A) MG A 802 (-3.2A) | 1.37A | 6djzC-3n3tA:undetectable | 6djzC-3n3tA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ptk | BETA-GLUCOSIDASEOS4BGLU12 (Oryza sativa) |
PF00232(Glyco_hydro_1) | 4 | TRP A 92LEU A 224TYR A 144GLN A 138 | None | 1.32A | 6djzC-3ptkA:undetectable | 6djzC-3ptkA:17.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qsv | MOTHERS AGAINSTDECAPENTAPLEGICHOMOLOG 4 (Mus musculus) |
PF03165(MH1) | 4 | LEU A 43TYR A 117ASP A 52GLU A 53 | None | 1.24A | 6djzC-3qsvA:undetectable | 6djzC-3qsvA:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qxf | ENDOGLUCANASE (Escherichiacoli) |
PF01270(Glyco_hydro_8) | 4 | TRP A 221LEU A 97ASP A 116GLU A 55 | None | 1.19A | 6djzC-3qxfA:undetectable | 6djzC-3qxfA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3thu | MANDELATE RACEMASE /MUCONATE LACTONIZINGENZYME FAMILYPROTEIN (Sphingomonassp. SKA58) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | TRP A 403LEU A 318ASP A 238GLU A 263 | NoneNone MG A 500 ( 4.5A) MG A 500 ( 2.6A) | 1.48A | 6djzC-3thuA:undetectable | 6djzC-3thuA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u5u | RAUCAFFRICINE-O-BETA-D-GLUCOSIDASE (Rauvolfiaserpentina) |
PF00232(Glyco_hydro_1) | 4 | TRP A 99LEU A 248TYR A 151GLN A 145 | None | 1.28A | 6djzC-3u5uA:undetectable | 6djzC-3u5uA:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ucq | AMYLOSUCRASE (Deinococcusgeothermalis) |
PF00128(Alpha-amylase) | 4 | LEU A 334ASP A 284GLN A 252GLU A 326 | NoneGOL A 720 (-3.0A)GOL A 720 ( 4.4A)TRS A 700 (-4.2A) | 1.34A | 6djzC-3ucqA:3.0 | 6djzC-3ucqA:18.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v4b | STARVATION SENSINGPROTEIN RSPA (Cellvibriojaponicus) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | TRP A 402LEU A 317ASP A 237GLU A 262 | NoneNone MG A 403 ( 4.6A) MG A 403 ( 2.5A) | 1.46A | 6djzC-3v4bA:undetectable | 6djzC-3v4bA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vcn | MANNONATEDEHYDRATASE (Caulobactervibrioides) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | TRP A 403LEU A 318ASP A 238GLU A 263 | NoneNone MG A 501 ( 4.6A) MG A 501 (-2.5A) | 1.50A | 6djzC-3vcnA:undetectable | 6djzC-3vcnA:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wau | 4-O-BETA-D-MANNOSYL-D-GLUCOSEPHOSPHORYLASE (Bacteroidesfragilis) |
PF04041(Glyco_hydro_130) | 4 | TRP A 225LEU A 269GLN A 190GLU A 257 | None | 1.25A | 6djzC-3wauA:undetectable | 6djzC-3wauA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a35 | MITOCHONDRIALENOLASE SUPERFAMILYMEMBER 1 (Homo sapiens) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | LEU A 326TYR A 194ASP A 254GLU A 280 | NoneNone MG A1445 (-2.6A) MG A1445 (-3.0A) | 1.48A | 6djzC-4a35A:undetectable | 6djzC-4a35A:18.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b9y | ALPHA-GLUCOSIDASE,PUTATIVE, ADG31B (Cellvibriojaponicus) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF16338(DUF4968)PF17137(DUF5110) | 4 | LEU A 300TYR A 189ASP A 509GLN A 491 | None | 1.39A | 6djzC-4b9yA:undetectable | 6djzC-4b9yA:16.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bla | MALTOSE-BINDINGPERIPLASMIC PROTEIN,SUPPRESSOR OF FUSEDHOMOLOG (Escherichiacoli;Homo sapiens) |
PF05076(SUFU)PF12470(SUFU_C)PF13416(SBP_bac_8) | 4 | LEU A 464TYR A 385ASP A 522GLN A 526 | None | 1.41A | 6djzC-4blaA:undetectable | 6djzC-4blaA:16.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cmn | INOSITOLPOLYPHOSPHATE5-PHOSPHATASE OCRL-1 (Homo sapiens) |
PF03372(Exo_endo_phos) | 4 | LEU A 376TYR A 513ASP A 451GLN A 445 | None | 1.50A | 6djzC-4cmnA:undetectable | 6djzC-4cmnA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4csq | UNCHARACTERIZEDPROTEIN (Pseudomonasaeruginosa) |
no annotation | 4 | LEU A 103ASP A 12GLN A 7GLU A 13 | None | 1.44A | 6djzC-4csqA:undetectable | 6djzC-4csqA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e4f | MANNONATEDEHYDRATASE (Pectobacteriumcarotovorum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | TRP A 404LEU A 319ASP A 239GLU A 264 | NoneNone MG A 504 (-4.0A) MG A 504 ( 2.5A) | 1.49A | 6djzC-4e4fA:undetectable | 6djzC-4e4fA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fdj | N-ACETYLGALACTOSAMINE-6-SULFATASE (Homo sapiens) |
PF00884(Sulfatase)PF14707(Sulfatase_C) | 4 | TRP A 141LEU A 128GLN A 148GLU A 126 | None | 1.41A | 6djzC-4fdjA:undetectable | 6djzC-4fdjA:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fi4 | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Caulobacter sp.K31) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | TRP A 403LEU A 318ASP A 238GLU A 263 | NoneNone MG A 501 ( 4.5A) MG A 501 ( 2.5A) | 1.49A | 6djzC-4fi4A:undetectable | 6djzC-4fi4A:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hst | GLUTARYL-7-AMINOCEPHALOSPORANIC ACIDACYLASE ALPHA CHAIN (Pseudomonas) |
PF01804(Penicil_amidase) | 4 | TRP A 149LEU A 161TYR A 121GLN A 62 | None | 1.47A | 6djzC-4hstA:undetectable | 6djzC-4hstA:24.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hyq | PHOSPHOLIPASE A1 (Streptomycesalbidoflavus) |
PF13472(Lipase_GDSL_2) | 4 | LEU A 205TYR A 35ASP A 10GLN A 65 | None | 1.50A | 6djzC-4hyqA:undetectable | 6djzC-4hyqA:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ip4 | MANDELATERACEMASE/MUCONATELACTONIZINGENZYME-LIKE PROTEIN (Ruegeria sp.TM1040) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | LEU A 316TYR A 186ASP A 246GLU A 272 | NoneNone MG A 503 (-2.6A) MG A 503 (-2.9A) | 1.40A | 6djzC-4ip4A:undetectable | 6djzC-4ip4A:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iqr | HEPATOCYTE NUCLEARFACTOR 4-ALPHA (Homo sapiens) |
PF00104(Hormone_recep)PF00105(zf-C4) | 4 | LEU A 329TYR A 319ASP A 273GLU A 276 | None | 1.24A | 6djzC-4iqrA:undetectable | 6djzC-4iqrA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j91 | KTR SYSTEM POTASSIUMUPTAKE PROTEIN A (Bacillussubtilis) |
PF02080(TrkA_C)PF02254(TrkA_N) | 4 | LEU A 162ASP A 138GLN A 134GLU A 218 | None | 1.13A | 6djzC-4j91A:undetectable | 6djzC-4j91A:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jc2 | ASFP504 (Alcyonium) |
PF01353(GFP) | 4 | LEU A 219TYR A 71ASP A 74GLN A 184 | None | 1.34A | 6djzC-4jc2A:undetectable | 6djzC-4jc2A:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kws | D-MANNONATEDEHYDRATASE (Chromohalobactersalexigens) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | TRP A 405LEU A 320ASP A 240GLU A 265 | NoneNone MG A 501 ( 4.7A) MG A 501 ( 2.5A) | 1.48A | 6djzC-4kwsA:undetectable | 6djzC-4kwsA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kws | D-MANNONATEDEHYDRATASE (Chromohalobactersalexigens) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | TRP A 405LEU A 320TYR A 171ASP A 213 | NoneNoneNone MG A 501 (-2.6A) | 1.43A | 6djzC-4kwsA:undetectable | 6djzC-4kwsA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l7z | HPCH/HPAI ALDOLASE (Chloroflexusaurantiacus) |
PF03328(HpcH_HpaI) | 4 | TRP A 272LEU A 96ASP A 61GLU A 60 | None | 1.49A | 6djzC-4l7zA:undetectable | 6djzC-4l7zA:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mh0 | RAP GUANINENUCLEOTIDE EXCHANGEFACTOR 4RAS-RELATED PROTEINRAP-1B (Mus musculus;Homo sapiens) |
PF00027(cNMP_binding)PF00617(RasGEF)PF00618(RasGEF_N)PF00071(Ras) | 4 | LEU E 893ASP R 38GLN R 43GLU R 37 | None | 1.25A | 6djzC-4mh0E:1.6 | 6djzC-4mh0E:14.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nex | ACETYLGLUTAMATEKINASE (Xylellafastidiosa) |
PF04768(NAT) | 4 | TRP A 409LEU A 319TYR A 352GLN A 431 | None | 0.93A | 6djzC-4nexA:undetectable | 6djzC-4nexA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nzr | PROTEIN M TD (Mycoplasmagenitalium) |
no annotation | 4 | LEU M 169TYR M 293ASP M 339GLU M 313 | NoneGOL M 501 ( 2.8A)NoneNone | 1.42A | 6djzC-4nzrM:undetectable | 6djzC-4nzrM:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o8m | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Actinobacillussuccinogenes) |
PF03480(DctP) | 4 | LEU A 95TYR A 147GLN A 36GLU A 73 | None2Q2 A 403 (-4.1A)None2Q2 A 403 (-2.8A) | 1.50A | 6djzC-4o8mA:undetectable | 6djzC-4o8mA:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ovj | EXTRACELLULARSOLUTE-BINDINGPROTEIN FAMILY 1 (Alicyclobacillusacidocaldarius) |
PF13416(SBP_bac_8) | 4 | LEU A 298ASP A 205GLN A 415GLU A 280 | None | 1.27A | 6djzC-4ovjA:undetectable | 6djzC-4ovjA:19.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r7o | GLYCEROPHOSPHORYLDIESTERPHOSPHODIESTERASE,PUTATIVE (Bacillusanthracis) |
PF03009(GDPD) | 4 | LEU A 195TYR A 280ASP A 72GLU A 152 | NoneGOL A 405 (-3.6A) MG A 401 (-3.0A) MG A 401 ( 3.1A) | 1.16A | 6djzC-4r7oA:undetectable | 6djzC-4r7oA:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wu0 | SIMILAR TO YTER(BACILUS SUBTILIS) (Clostridiumacetobutylicum) |
PF07470(Glyco_hydro_88) | 4 | TRP A 204LEU A 19GLN A 250GLU A 344 | None | 1.49A | 6djzC-4wu0A:undetectable | 6djzC-4wu0A:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xmv | AMINOPEPTIDASE N (Escherichiacoli) |
PF01433(Peptidase_M1)PF11940(DUF3458)PF17432(DUF3458_C) | 4 | LEU A 731TYR A 660ASP A 712GLN A 665 | NoneNoneGOL A 913 (-3.4A)None | 1.44A | 6djzC-4xmvA:undetectable | 6djzC-4xmvA:13.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xwt | DR2417 (Deinococcusradiodurans) |
PF00753(Lactamase_B)PF07521(RMMBL) | 4 | LEU A 93TYR A 276GLN A 316GLU A 87 | None | 1.46A | 6djzC-4xwtA:undetectable | 6djzC-4xwtA:17.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ygs | HYDROLASE (Thermococcusonnurineus) |
PF13419(HAD_2) | 4 | LEU A 23TYR A 114ASP A 9GLU A 15 | None | 1.42A | 6djzC-4ygsA:undetectable | 6djzC-4ygsA:23.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z0z | AURONE SYNTHASE (Coreopsisgrandiflora) |
PF00264(Tyrosinase)PF12142(PPO1_DWL) | 4 | LEU A 139TYR A 130GLN A 44GLU A 322 | None | 1.46A | 6djzC-4z0zA:undetectable | 6djzC-4z0zA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zfm | PUTATIVE6-PHOSPHO-BETA-GALACTOBIOSIDASE (Geobacillusstearothermophilus) |
PF00232(Glyco_hydro_1) | 4 | TRP A 85LEU A 203TYR A 135GLN A 129 | None | 1.29A | 6djzC-4zfmA:undetectable | 6djzC-4zfmA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zgv | FERREDOXIN RECEPTOR (Pectobacteriumatrosepticum) |
PF07715(Plug) | 4 | LEU A 600TYR A 459GLN A 478GLU A 586 | None | 1.26A | 6djzC-4zgvA:undetectable | 6djzC-4zgvA:13.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a8r | METHYL-COENZYME MREDUCTASE II SUBUNITALPHAMETHYL-COENZYME MREDUCTASE II SUBUNITGAMMA (Methanothermobactermarburgensis;Methanothermobactermarburgensis) |
PF02249(MCR_alpha)PF02745(MCR_alpha_N)PF02241(MCR_beta)PF02783(MCR_beta_N) | 4 | LEU A 468TYR B 190ASP B 228GLN B 220 | None | 1.41A | 6djzC-5a8rA:undetectable | 6djzC-5a8rA:17.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cd6 | TPR-DOMAINCONTAINING PROTEIN (Parabacteroidesdistasonis) |
PF17128(DUF5107) | 4 | LEU A 488TYR A 428ASP A 399GLU A 398 | None | 1.41A | 6djzC-5cd6A:1.0 | 6djzC-5cd6A:17.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dz7 | POLYKETIDEBIOSYNTHESIS PROTEINPKSE (Bacillussubtilis) |
PF00698(Acyl_transf_1) | 4 | LEU A 234TYR A 62ASP A 101GLN A 30 | None | 1.45A | 6djzC-5dz7A:undetectable | 6djzC-5dz7A:23.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ej1 | PUTATIVE CELLULOSESYNTHASE (Rhodobactersphaeroides) |
PF00535(Glycos_transf_2)PF03552(Cellulose_synt)PF07238(PilZ) | 4 | LEU A 205ASP A 248GLN A 379GLU A 151 | None | 1.38A | 6djzC-5ej1A:undetectable | 6djzC-5ej1A:15.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fpw | PRO CATHEPSIN B S9 (Trypanosomacongolense) |
PF00112(Peptidase_C1) | 4 | TRP A 27LEU A 256ASP A 252GLN A 21 | None | 1.48A | 6djzC-5fpwA:undetectable | 6djzC-5fpwA:18.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5hk2 | SIGMA NON-OPIOIDINTRACELLULARRECEPTOR 1 (Homo sapiens) |
PF04622(ERG2_Sigma1R) | 6 | TRP A 89LEU A 95TYR A 120ASP A 126GLN A 135GLU A 172 | NoneNoneNone61V A 301 (-3.2A)None61V A 301 (-2.9A) | 0.34A | 6djzC-5hk2A:34.1 | 6djzC-5hk2A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5in8 | ARISTOLOCHENESYNTHASE (Aspergillusterreus) |
no annotation | 4 | LEU A 178TYR A 168ASP A 214GLN A 240 | None | 1.45A | 6djzC-5in8A:0.6 | 6djzC-5in8A:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j98 | VP3 (Slow beeparalysis virus) |
PF00073(Rhv) | 4 | LEU C 367TYR C 110ASP C 416GLU C 372 | None | 1.33A | 6djzC-5j98C:undetectable | 6djzC-5j98C:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jr3 | CARMINOMYCIN4-O-METHYLTRANSFERASE DNRK (Streptomycespeucetius) |
PF00891(Methyltransf_2) | 4 | LEU A 302TYR A 342ASP A 287GLN A 334 | None4MU A 402 ( 4.6A)NoneNone | 1.38A | 6djzC-5jr3A:undetectable | 6djzC-5jr3A:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k04 | UNCHARACTERIZEDPROTEINN-TERMINALACETYLTRANSFERASE BCOMPLEX SUBUNIT NAT3 (Candidaalbicans;Candidaalbicans) |
PF09797(NatB_MDM20)PF08445(FR47) | 4 | LEU B 123TYR B 57ASP B 21GLN A 436 | COA B 202 (-2.9A)NoneCOA B 202 ( 4.0A)None | 1.34A | 6djzC-5k04B:undetectable | 6djzC-5k04B:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mkg | DIGUANYLATEPHOSPHODIESTERASE (Pseudomonasaeruginosa) |
PF00563(EAL) | 4 | LEU B 127ASP B 160GLN B 184GLU B 130 | None CA B 302 (-2.5A)C2E B 304 (-3.1A) CA B 302 (-3.3A) | 1.38A | 6djzC-5mkgB:undetectable | 6djzC-5mkgB:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mza | ERYTHROCYTE MEMBRANEPROTEIN 1 (PFEMP1) (Plasmodiumfalciparum) |
PF05424(Duffy_binding) | 4 | LEU A 932ASP A 922GLN A 822GLU A 925 | None | 1.26A | 6djzC-5mzaA:undetectable | 6djzC-5mzaA:17.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ogs | WD REPEAT ANDHMG-BOX DNA-BINDINGPROTEIN 1 (Homo sapiens) |
no annotation | 4 | LEU A 440ASP A 534GLN A 531GLU A 502 | None | 1.49A | 6djzC-5ogsA:undetectable | 6djzC-5ogsA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5opt | 40S RIBOSOMALPROTEIN S1240S RIBOSOMALPROTEIN S10,PUTATIVE (Trypanosomacruzi;Trypanosomacruzi) |
no annotationno annotation | 4 | LEU i 43TYR n 86ASP n 11GLN n 48 | NoneNone U E1725 ( 3.6A)None | 1.40A | 6djzC-5opti:undetectable | 6djzC-5opti:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oqp | CONDENSIN COMPLEXSUBUNIT 3 (Saccharomycescerevisiae) |
no annotation | 4 | LEU A 724ASP A 771GLN A 841GLU A 726 | None | 1.43A | 6djzC-5oqpA:undetectable | 6djzC-5oqpA:13.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t8v | PUTATIVEUNCHARACTERIZEDPROTEIN (Chaetomiumthermophilum) |
PF12765(Cohesin_HEAT)PF12830(Nipped-B_C) | 4 | LEU A 501ASP A 583GLN A 447GLU A 508 | None | 1.44A | 6djzC-5t8vA:undetectable | 6djzC-5t8vA:10.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t9c | GLYCEROPHOSPHORYLDIESTERPHOSPHODIESTERASE (Bacillussubtilis) |
PF03009(GDPD) | 4 | LEU E 195TYR E 259ASP E 72GLU E 152 | NoneG3P E 302 (-3.8A) CA E 301 ( 2.9A) CA E 301 ( 3.2A) | 1.13A | 6djzC-5t9cE:undetectable | 6djzC-5t9cE:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u8s | DNA REPLICATIONLICENSING FACTORMCM4 (Saccharomycescerevisiae) |
PF00493(MCM)PF14551(MCM_N)PF17207(MCM_OB) | 4 | LEU 4 544TYR 4 706ASP 4 703GLN 4 797 | None | 1.18A | 6djzC-5u8s4:undetectable | 6djzC-5u8s4:13.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x6o | SERINE/THREONINE-PROTEIN KINASE MEC1 (Saccharomycescerevisiae) |
no annotation | 4 | TRP C1158TYR C1297GLN C1151GLU C1140 | None | 1.48A | 6djzC-5x6oC:undetectable | 6djzC-5x6oC:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y4k | DMSP LYASE DDDY (Acinetobacterbereziniae) |
no annotation | 4 | TRP A 315LEU A 355TYR A 262GLN A 294 | None | 1.41A | 6djzC-5y4kA:4.8 | 6djzC-5y4kA:18.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fdf | TRNA(CYTOSINE(38)-C(5))-METHYLTRANSFERASE (Schizosaccharomycespombe) |
no annotation | 4 | TRP A 294LEU A 285TYR A 211GLU A 203 | None | 1.27A | 6djzC-6fdfA:undetectable | 6djzC-6fdfA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6frv | GLUCOAMYLASE (Aspergillusniger) |
no annotation | 4 | LEU A 446ASP A 354GLN A 292GLU A 350 | None | 1.48A | 6djzC-6frvA:undetectable | 6djzC-6frvA:undetectable |