SIMILAR PATTERNS OF AMINO ACIDS FOR 6DJZ_B_GMJB301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2v METHYLAMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		5 ASP A 197
GLN A 171
VAL A 196
GLU A 200
ALA A  86
 None
 1.42A 6djzB-1a2vA:
0.9		 6djzB-1a2vA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a80 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE A

(Corynebacterium
sp.) 		PF00248
(Aldo_ket_red) 		4 TYR A 105
GLN A 161
GLU A  53
ALA A  89
 None
NDP  A 300 (-3.3A)
None
None
 1.24A 6djzB-1a80A:
0.0		 6djzB-1a80A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ece ENDOCELLULASE E1

(Acidothermus
cellulolyticus) 		PF00150
(Cellulase) 		4 ASP A 344
GLN A  52
VAL A 339
ALA A  24
 None
 1.06A 6djzB-1eceA:
0.0		 6djzB-1eceA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0i PHOSPHOLIPASE D

(Streptomyces
sp. PMF) 		PF13091
(PLDc_2) 		4 GLN A 447
VAL A 375
GLU A 338
ALA A 484
 None
 1.14A 6djzB-1f0iA:
0.0		 6djzB-1f0iA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f9k ACIDIC LECTIN

(Psophocarpus
tetragonolobus) 		PF00139
(Lectin_legB) 		4 ASP A 125
GLN A 128
VAL A 135
GLU A 123
 CA  A 302 ( 2.2A)
None
None
MN  A 300 (-3.0A)
 1.02A 6djzB-1f9kA:
0.1		 6djzB-1f9kA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 TYR B 394
ASP B 401
VAL B 402
ALA B 704
 None
 1.20A 6djzB-1ffvB:
0.0		 6djzB-1ffvB:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggm GLYCINE--TRNA LIGASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 ASP A 293
GLN A 278
VAL A 292
GLU A 304
 None
None
None
GAP  A1550 ( 3.8A)
 1.20A 6djzB-1ggmA:
0.0		 6djzB-1ggmA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 TYR A  27
ASP A 544
GLN A   9
VAL A 547
 None
 1.26A 6djzB-1hcyA:
0.0		 6djzB-1hcyA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA

(Thermus
aquaticus) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		4 ASP A 201
GLN A 212
VAL A 204
ALA A 177
 None
 0.97A 6djzB-1hqmA:
undetectable		 6djzB-1hqmA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1d D-HYDANTOINASE

(Geobacillus
stearothermophilus) 		PF01979
(Amidohydro_1) 		4 ASP A 344
GLN A 266
GLU A 343
ALA A 412
 None
 1.19A 6djzB-1k1dA:
undetectable		 6djzB-1k1dA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhz METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		4 GLN D 150
VAL D 239
GLU D 209
ALA D 120
 None
None
FE  D 802 ( 3.2A)
None
 1.12A 6djzB-1mhzD:
undetectable		 6djzB-1mhzD:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qup SUPEROXIDE DISMUTASE
1 COPPER CHAPERONE

(Saccharomyces
cerevisiae) 		PF00080
(Sod_Cu)
PF00403
(HMA) 		4 TYR A 129
GLN A  88
VAL A 206
ALA A 126
 None
 1.20A 6djzB-1qupA:
undetectable		 6djzB-1qupA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sd5 PUTATIVE
ANTITERMINATOR

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg)
PF03861
(ANTAR) 		4 ASP A  65
GLN A  96
VAL A  66
GLU A  20
 None
 1.19A 6djzB-1sd5A:
undetectable		 6djzB-1sd5A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC

(Escherichia
coli) 		PF03009
(GDPD) 		4 TYR A 313
ASP A  65
GLU A 171
ALA A 237
 GOL  A1605 (-3.8A)
MG  A1601 ( 2.7A)
MG  A1601 ( 2.9A)
None
 0.99A 6djzB-1t8qA:
undetectable		 6djzB-1t8qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgd CHALCONE REDUCTASE

(Medicago sativa) 		PF00248
(Aldo_ket_red) 		4 TYR A 117
GLN A 188
GLU A  61
ALA A 101
 None
NAP  A 755 (-4.0A)
None
None
 1.26A 6djzB-1zgdA:
undetectable		 6djzB-1zgdA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsw GLYOXALASE FAMILY
PROTEIN

(Bacillus cereus) 		PF00903
(Glyoxalase) 		4 TYR A 111
GLN A 193
VAL A 183
GLU A 189
 None
 1.14A 6djzB-1zswA:
undetectable		 6djzB-1zswA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atm HYALURONOGLUCOSAMINI
DASE

(Vespula
vulgaris) 		PF01630
(Glyco_hydro_56) 		4 TYR A 184
ASP A 107
VAL A 105
GLU A 109
 None
MES  A 500 (-3.6A)
None
MES  A 500 (-3.6A)
 1.17A 6djzB-2atmA:
undetectable		 6djzB-2atmA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecf DIPEPTIDYL PEPTIDASE
IV

(Stenotrophomonas
maltophilia) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 TYR A 650
GLN A 305
GLU A 207
ALA A 528
 None
 1.19A 6djzB-2ecfA:
undetectable		 6djzB-2ecfA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 TYR A 114
GLN A 190
GLU A  58
ALA A  98
 None
NAP  A1001 (-4.0A)
None
None
 1.26A 6djzB-2fvlA:
undetectable		 6djzB-2fvlA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grv LPQW

(Mycolicibacterium
smegmatis) 		PF00496
(SBP_bac_5) 		4 ASP A 134
GLN A  48
VAL A 133
ALA A 326
 None
 1.24A 6djzB-2grvA:
undetectable		 6djzB-2grvA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is7 ALDOSE REDUCTASE

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 TYR A 107
GLN A 183
GLU A  51
ALA A  91
 None
NAP  A 316 (-3.7A)
None
None
 1.26A 6djzB-2is7A:
undetectable		 6djzB-2is7A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 4 TYR A 293
ASP A 276
VAL A 274
GLU A 254
 None
CA  A 620 (-2.1A)
None
CA  A 620 (-3.3A)
 1.23A 6djzB-2quaA:
undetectable		 6djzB-2quaA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN

(Bacillus
thuringiensis) 		PF01338
(Bac_thur_toxin) 		4 TYR A  48
ASP A 179
VAL A 125
GLU A 178
 TYR  A  48 ( 1.3A)
ASP  A 179 ( 0.6A)
VAL  A 125 ( 0.5A)
GLU  A 178 ( 0.5A)
 1.25A 6djzB-2rciA:
undetectable		 6djzB-2rciA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uw2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE M2
SUBUNIT

(Homo sapiens) 		PF00268
(Ribonuc_red_sm) 		4 ASP A 138
GLN A 165
VAL A 141
ALA A 104
 None
 1.22A 6djzB-2uw2A:
undetectable		 6djzB-2uw2A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vda TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 ASP A 293
VAL A 287
GLU A 294
ALA A 690
 None
 1.23A 6djzB-2vdaA:
undetectable		 6djzB-2vdaA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhf UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE CYLD

(Homo sapiens) 		PF00443
(UCH) 		4 TYR A 955
VAL A 616
GLU A 860
ALA A 884
 None
 1.16A 6djzB-2vhfA:
undetectable		 6djzB-2vhfA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00344
(SecY)
PF10559
(Plug_translocon) 		4 GLN A 149
VAL A  51
GLU A  81
ALA A 138
 None
 1.13A 6djzB-2ww9A:
undetectable		 6djzB-2ww9A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzm ALDO-KETO REDUCTASE

(Mycolicibacterium
smegmatis) 		PF00248
(Aldo_ket_red) 		4 TYR A 113
GLN A 169
GLU A  61
ALA A  97
 None
 1.26A 6djzB-2wzmA:
undetectable		 6djzB-2wzmA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8z LIPASE

(Pseudomonas sp.
MIS38) 		PF00353
(HemolysinCabind) 		4 TYR A 292
ASP A 275
VAL A 273
GLU A 253
 None
CA  A 618 (-2.2A)
None
CA  A 618 (-3.3A)
 1.11A 6djzB-2z8zA:
undetectable		 6djzB-2z8zA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqu AT4G19810

(Arabidopsis
thaliana) 		PF00704
(Glyco_hydro_18) 		4 TYR A 321
ASP A 329
VAL A 326
ALA A 341
 None
 1.02A 6djzB-3aquA:
undetectable		 6djzB-3aquA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axi OLIGO-1,6-GLUCOSIDAS
E IMA1

(Saccharomyces
cerevisiae) 		PF00128
(Alpha-amylase) 		4 TYR A 347
ASP A 307
VAL A 308
ALA A 277
 None
 1.24A 6djzB-3axiA:
undetectable		 6djzB-3axiA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		4 TYR A 113
GLN A 157
GLU A 181
ALA A 142
 ACT  A   1 ( 4.7A)
None
None
None
 1.11A 6djzB-3cghA:
undetectable		 6djzB-3cghA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebc TYPE-2 RESTRICTION
ENZYME HINCII

(Haemophilus
influenzae) 		PF09226
(Endonuc-HincII) 		4 TYR A   8
ASP A 172
VAL A 183
ALA A 188
 None
 1.25A 6djzB-3ebcA:
undetectable		 6djzB-3ebcA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk8 DISULPHIDE ISOMERASE

(Xylella
fastidiosa) 		PF13899
(Thioredoxin_7) 		4 ASP A  85
VAL A  86
GLU A  25
ALA A  18
 None
 1.19A 6djzB-3fk8A:
undetectable		 6djzB-3fk8A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		4 GLN A 323
VAL A 254
GLU A 281
ALA A 342
 None
 1.16A 6djzB-3g05A:
undetectable		 6djzB-3g05A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd5 ORNITHINE
CARBAMOYLTRANSFERASE

(Gloeobacter
violaceus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ASP A 144
VAL A 141
GLU A 296
ALA A 275
 None
 0.90A 6djzB-3gd5A:
undetectable		 6djzB-3gd5A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs0 COBRA VENOM FACTOR

(Naja kaouthia) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		4 TYR A 338
ASP A 512
VAL A 425
ALA A 410
 None
 1.25A 6djzB-3hs0A:
undetectable		 6djzB-3hs0A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijl MUCONATE
CYCLOISOMERASE

(Bacteroides
thetaiotaomicron) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A  94
ASP A 276
GLU A 277
ALA A  64
 DGL  A 385 (-4.5A)
MG  A 386 (-3.1A)
MG  A 386 ( 3.9A)
None
 1.19A 6djzB-3ijlA:
undetectable		 6djzB-3ijlA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg3 ISOCITRATE LYASE

(Yersinia pestis) 		PF00463
(ICL) 		4 TYR A 280
ASP A 247
GLN A 212
ALA A 236
 None
 1.23A 6djzB-3lg3A:
undetectable		 6djzB-3lg3A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ln3 DIHYDRODIOL
DEHYDROGENASE

(Mus musculus) 		PF00248
(Aldo_ket_red) 		4 TYR A 114
GLN A 190
GLU A  58
ALA A  98
 None
NAD  A 327 (-3.6A)
MLY  A 105 ( 4.3A)
None
 1.22A 6djzB-3ln3A:
undetectable		 6djzB-3ln3A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mos TRANSKETOLASE

(Homo sapiens) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 TYR A 147
ASP A 119
VAL A 120
ALA A 293
 None
 1.26A 6djzB-3mosA:
undetectable		 6djzB-3mosA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		4 ASP A 570
GLN A 541
GLU A 572
ALA A 373
 None
 1.21A 6djzB-3opyA:
undetectable		 6djzB-3opyA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owu STEROID
DELTA-ISOMERASE

(Pseudomonas
putida) 		PF12680
(SnoaL_2) 		4 TYR A  32
ASP A 103
GLN A 117
VAL A 104
 None
EQU  A 200 (-2.9A)
None
None
 1.26A 6djzB-3owuA:
undetectable		 6djzB-3owuA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 TYR B 360
ASP B 534
VAL B 447
ALA B 432
 None
 1.22A 6djzB-3prxB:
2.4		 6djzB-3prxB:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd8 PROBABLE
BACTERIOFERRITIN
BFRB

(Mycobacterium
tuberculosis) 		PF00210
(Ferritin) 		4 GLN A  98
VAL A 102
GLU A 131
ALA A 167
 None
 1.24A 6djzB-3qd8A:
undetectable		 6djzB-3qd8A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfb PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF13185
(GAF_2) 		4 TYR A  51
ASP A 128
VAL A  46
GLU A 110
 SME  A6888 (-4.9A)
SME  A6888 (-2.7A)
None
SME  A6888 (-2.1A)
 0.90A 6djzB-3rfbA:
undetectable		 6djzB-3rfbA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tpf ORNITHINE
CARBAMOYLTRANSFERASE

(Campylobacter
jejuni) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ASP A 131
VAL A 128
GLU A 284
ALA A 263
 None
 0.80A 6djzB-3tpfA:
undetectable		 6djzB-3tpfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqe MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE

(Coxiella
burnetii) 		PF00698
(Acyl_transf_1) 		4 TYR A  43
GLN A  59
GLU A 116
ALA A  37
 None
 1.25A 6djzB-3tqeA:
undetectable		 6djzB-3tqeA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Rattus
norvegicus) 		PF05028
(PARG_cat) 		4 ASP A 733
VAL A 818
GLU A 751
ALA A 870
 None
None
A1R  A1001 (-4.2A)
A1R  A1001 (-3.8A)
 1.23A 6djzB-3uelA:
undetectable		 6djzB-3uelA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uf6 LMO1369 PROTEIN

(Listeria
monocytogenes) 		PF01515
(PTA_PTB) 		4 GLN A 186
VAL A 175
GLU A 173
ALA A 223
 None
 1.13A 6djzB-3uf6A:
undetectable		 6djzB-3uf6A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2

(Homo sapiens) 		PF00268
(Ribonuc_red_sm) 		4 ASP A 138
GLN A 165
VAL A 141
ALA A 104
 None
FE  A 402 (-4.5A)
None
None
 1.12A 6djzB-3vpoA:
undetectable		 6djzB-3vpoA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbh ALKALINE PHOSPHATASE

(Halomonas sp.
#593) 		PF00245
(Alk_phosphatase) 		4 ASP A  64
GLN A  71
VAL A  63
GLU A  81
 None
 1.12A 6djzB-3wbhA:
undetectable		 6djzB-3wbhA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcz ALDO-KETO REDUCTASE
2E

(Bombyx mori) 		PF00248
(Aldo_ket_red) 		4 TYR A 117
GLN A 180
GLU A  61
ALA A 101
 None
NAP  A 401 (-3.3A)
None
None
 1.23A 6djzB-3wczA:
undetectable		 6djzB-3wczA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq8 BETA-GLUCOSIDASE

(Pyrococcus
furiosus) 		PF00232
(Glyco_hydro_1) 		4 TYR A 306
ASP A 269
VAL A 311
ALA A 393
 None
 0.99A 6djzB-3wq8A:
undetectable		 6djzB-3wq8A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		4 ASP A 257
VAL A 254
GLU A 268
ALA A 531
 MG  A1767 (-2.5A)
None
2PN  A1773 (-3.7A)
None
 1.12A 6djzB-4a01A:
undetectable		 6djzB-4a01A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aip FE-REGULATED PROTEIN
B

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 TYR A 445
ASP A 369
VAL A 323
ALA A 158
 None
 1.00A 6djzB-4aipA:
undetectable		 6djzB-4aipA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE

(Trypanosoma
brucei) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ASP A 336
GLN A 394
GLU A 342
ALA A 367
 None
 1.22A 6djzB-4bi9A:
undetectable		 6djzB-4bi9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cog KYNURENINE
FORMAMIDASE

(Burkholderia
cenocepacia) 		PF04199
(Cyclase) 		4 TYR A  59
VAL A 126
GLU A 172
ALA A  55
 None
None
ZN  A 401 (-2.0A)
None
 1.05A 6djzB-4cogA:
undetectable		 6djzB-4cogA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffl PYLC

(Methanosarcina
barkeri) 		PF02655
(ATP-grasp_3) 		4 ASP A 241
GLN A  12
GLU A 239
ALA A 141
 MG  A 905 ( 2.7A)
LYS  A 901 (-3.9A)
MG  A 905 ( 1.7A)
ADP  A 902 ( 4.2A)
 1.22A 6djzB-4fflA:
undetectable		 6djzB-4fflA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn5 ELONGATION FACTOR G
1

(Pseudomonas
aeruginosa) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 TYR A 285
ASP A 184
GLN A  78
ALA A 226
 None
 1.10A 6djzB-4fn5A:
undetectable		 6djzB-4fn5A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzi PROSTAGLANDIN F
SYNTHASE

(Trypanosoma
cruzi) 		PF00248
(Aldo_ket_red) 		4 TYR A 108
GLN A 162
GLU A  56
ALA A  92
 None
 1.23A 6djzB-4fziA:
undetectable		 6djzB-4fziA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)

(Schistosoma
japonicum) 		PF00248
(Aldo_ket_red) 		4 TYR A 107
GLN A 181
GLU A  51
ALA A  91
 None
 1.23A 6djzB-4hbkA:
undetectable		 6djzB-4hbkA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzp BIFUNCTIONAL
METHYLMALONYL-COA:AC
P
ACYLTRANSFERASE/DECA
RBOXYLASE

(Streptomyces
atroolivaceus) 		no annotation 4 ASP A 255
GLN A 309
VAL A 254
ALA A 190
 None
 1.22A 6djzB-4hzpA:
undetectable		 6djzB-4hzpA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjj CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Thermobifida
fusca) 		PF02011
(Glyco_hydro_48) 		4 ASP A 498
GLN A 623
VAL A 499
ALA A  41
 CBI  A 701 ( 3.1A)
None
None
CBI  A 701 ( 3.9A)
 1.15A 6djzB-4jjjA:
undetectable		 6djzB-4jjjA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3f PROBABLE
TONB-DEPENDENT
RECEPTOR

(Pseudomonas
aeruginosa) 		PF03180
(Lipoprotein_9) 		4 TYR A  82
GLN A  62
VAL A  65
ALA A 130
 None
 1.24A 6djzB-4k3fA:
undetectable		 6djzB-4k3fA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k49 ESTERASE YDII

(Escherichia
coli) 		no annotation 4 GLN C 112
VAL C  80
GLU C  63
ALA C  87
 None
 1.26A 6djzB-4k49C:
undetectable		 6djzB-4k49C:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzv EPITHELIAL CELL
ADHESION MOLECULE

(Homo sapiens) 		PF00086
(Thyroglobulin_1) 		4 ASP A 211
GLN A 175
VAL A 207
ALA A  71
 None
 1.17A 6djzB-4mzvA:
undetectable		 6djzB-4mzvA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz0 GENOME POLYPROTEIN

(Cardiovirus A) 		PF00680
(RdRP_1) 		4 TYR A 285
ASP A 177
GLN A 155
VAL A 178
 None
 1.18A 6djzB-4nz0A:
undetectable		 6djzB-4nz0A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 GLN A 902
VAL A 947
GLU A 949
ALA A 867
 None
 1.20A 6djzB-4o9xA:
undetectable		 6djzB-4o9xA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4op4 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Vibrio cholerae) 		PF01546
(Peptidase_M20) 		4 ASP A  70
GLN A  27
GLU A 136
ALA A 100
 None
None
ZN  A 302 (-1.7A)
None
 1.16A 6djzB-4op4A:
undetectable		 6djzB-4op4A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4sbv SOUTHERN BEAN MOSAIC
VIRUS COAT PROTEIN

(Southern bean
mosaic virus) 		PF00729
(Viral_coat) 		4 GLN A 136
VAL A 225
GLU A  89
ALA A 202
 None
 1.15A 6djzB-4sbvA:
undetectable		 6djzB-4sbvA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y90 TRIOSEPHOSPHATE
ISOMERASE

(Deinococcus
radiodurans) 		PF00121
(TIM) 		4 TYR A 163
GLN A 143
GLU A 182
ALA A 175
 None
None
GOL  A 303 (-2.4A)
None
 1.17A 6djzB-4y90A:
undetectable		 6djzB-4y90A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zq8 ISOPRENOID SYNTHASE

(Streptomyces
lydicus) 		no annotation 4 ASP A 108
VAL A 107
GLU A 113
ALA A 199
 None
 1.12A 6djzB-4zq8A:
undetectable		 6djzB-4zq8A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		4 ASP A 427
GLN A 412
VAL A 426
ALA A 838
 None
 0.95A 6djzB-5dkxA:
undetectable		 6djzB-5dkxA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fpr DNA LIGASE

(Staphylococcus
aureus) 		PF01653
(DNA_ligase_aden) 		4 GLN A 129
VAL A  73
GLU A 140
ALA A 198
 None
 1.06A 6djzB-5fprA:
undetectable		 6djzB-5fprA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT THETA
T-COMPLEX PROTEIN 1
SUBUNIT ZETA

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1)
PF00118
(Cpn60_TCP1) 		4 TYR z 386
ASP z 163
VAL z 162
ALA q  88
 None
 0.91A 6djzB-5gw5z:
undetectable		 6djzB-5gw5z:
19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hk2 SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1

(Homo sapiens) 		PF04622
(ERG2_Sigma1R) 		4 ASP A 126
VAL A 152
GLU A 172
ALA A  86
 61V  A 301 (-3.2A)
None
61V  A 301 (-2.9A)
None
 1.20A 6djzB-5hk2A:
35.1		 6djzB-5hk2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hk2 SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1

(Homo sapiens) 		PF04622
(ERG2_Sigma1R) 		6 TYR A 120
ASP A 126
GLN A 135
VAL A 152
GLU A 172
ALA A 185
 None
61V  A 301 (-3.2A)
None
None
61V  A 301 (-2.9A)
61V  A 301 ( 4.2A)
 0.36A 6djzB-5hk2A:
35.1		 6djzB-5hk2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic8 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 4 GLN A 341
VAL A 321
GLU A 298
ALA A 383
 None
 1.01A 6djzB-5ic8A:
undetectable		 6djzB-5ic8A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jho ELECTRONEUTRAL
SODIUM BICARBONATE
EXCHANGER 1

(Homo sapiens) 		PF07565
(Band_3_cyto) 		4 ASP A 328
GLN A  47
VAL A 319
GLU A 325
 None
 1.06A 6djzB-5jhoA:
undetectable		 6djzB-5jhoA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdr ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
ALPHA

(Staphylococcus
aureus) 		PF03255
(ACCA) 		4 ASP A  91
GLN A 111
GLU A 131
ALA A 164
 None
None
None
SO4  A 402 (-3.6A)
 1.20A 6djzB-5kdrA:
undetectable		 6djzB-5kdrA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 TYR X 108
GLN X 184
GLU X  52
ALA X  92
 None
NAP  X 401 (-3.8A)
None
None
 1.20A 6djzB-5liyX:
undetectable		 6djzB-5liyX:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1s DNA POLYMERASE III
SUBUNIT THETA

(Escherichia
coli) 		PF06440
(DNA_pol3_theta) 		4 ASP F  19
GLN F  44
VAL F  18
ALA F  62
 None
 1.02A 6djzB-5m1sF:
undetectable		 6djzB-5m1sF:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m28 MALE1

(Lactobacillus
casei) 		PF13416
(SBP_bac_8) 		4 TYR A 164
GLN A  81
VAL A  77
ALA A 266
 MLR  A 401 (-2.8A)
MLR  A 401 (-3.9A)
None
None
 1.23A 6djzB-5m28A:
undetectable		 6djzB-5m28A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1q METHYL-COENZYME M
REDUCTASE III FROM
METHANOTHERMOCOCCUS
THERMOLITHOTROPHICUS
SUBUNIT BETA

(Methanothermococcus
thermolithotrophicus) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ASP B 278
VAL B 280
GLU B 277
ALA B 258
 None
 1.24A 6djzB-5n1qB:
undetectable		 6djzB-5n1qB:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nit GLUCOSE OXIDASE

(Aspergillus
niger) 		no annotation 4 TYR A 515
ASP A 424
GLN A 464
VAL A 425
 FAD  A 601 (-4.3A)
None
None
None
 1.01A 6djzB-5nitA:
undetectable		 6djzB-5nitA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0x PUTATIVE FERRIC
REDUCTASE

(Cylindrospermum
stagnale) 		PF08022
(FAD_binding_8)
PF08030
(NAD_binding_6) 		4 TYR A 684
ASP A 646
GLN A 676
GLU A 649
 GOL  A 826 ( 4.6A)
None
None
None
 1.18A 6djzB-5o0xA:
undetectable		 6djzB-5o0xA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1m RUBBER OXYGENASE

(Streptomyces
sp. K30) 		PF09995
(DUF2236) 		4 ASP A 272
GLN A 262
VAL A  42
ALA A 104
 None
 1.18A 6djzB-5o1mA:
undetectable		 6djzB-5o1mA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6f LPXTG-MOTIF CELL
WALL ANCHOR DOMAIN
PROTEIN

(Mobiluncus
mulieris) 		no annotation 4 ASP A 245
GLN A 235
VAL A 238
ALA A 265
 None
 1.11A 6djzB-5u6fA:
undetectable		 6djzB-5u6fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7w APYRASE

(Trifolium
repens) 		PF01150
(GDA1_CD39) 		4 ASP A  37
GLN A 388
GLU A  39
ALA A 395
 None
 0.97A 6djzB-5u7wA:
undetectable		 6djzB-5u7wA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uoh CARBOXYLESTERASE A

(Mycobacterium
tuberculosis) 		PF00561
(Abhydrolase_1) 		4 ASP A 259
GLN A 396
GLU A 262
ALA A 412
 None
 1.25A 6djzB-5uohA:
undetectable		 6djzB-5uohA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE

(Naegleria
fowleri) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 TYR A 472
VAL A 434
GLU A 432
ALA A 467
 None
None
None
EDO  A 505 ( 4.6A)
 1.24A 6djzB-5v96A:
undetectable		 6djzB-5v96A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf3 MAJOR CAPSID PROTEIN

(Escherichia
virus T4) 		PF07068
(Gp23) 		4 TYR A 433
GLN A 427
VAL A 412
ALA A 314
 None
 1.25A 6djzB-5vf3A:
undetectable		 6djzB-5vf3A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w6m HISTIDINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		no annotation 4 ASP A 488
VAL A 489
GLU A 470
ALA A 416
 None
 1.23A 6djzB-5w6mA:
undetectable		 6djzB-5w6mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x33 LTB4
RECEPTOR,LYSOZYME,LT
B4 RECEPTOR

(Cavia
porcellus;
Escherichia
virus T4) 		no annotation 4 TYR A 174
ASP A 243
VAL A 242
GLU A 187
 None
 1.06A 6djzB-5x33A:
undetectable		 6djzB-5x33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		4 ASP C2964
GLN C3291
GLU C2960
ALA C3255
 None
 1.18A 6djzB-5y3rC:
undetectable		 6djzB-5y3rC:
4.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aqh LYSINE--TRNA LIGASE

(Mycolicibacterium
thermoresistibile) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 ASP A 412
VAL A 387
GLU A 419
ALA A 213
 None
None
KRS  A 602 (-3.8A)
LYS  A 601 (-3.4A)
 1.18A 6djzB-6aqhA:
undetectable		 6djzB-6aqhA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cia ALDO/KETO REDUCTASE

(Klebsiella
pneumoniae) 		no annotation 4 TYR A 110
GLN A 165
GLU A  61
ALA A  94
 None
NDP  A 301 (-4.2A)
None
None
 1.20A 6djzB-6ciaA:
undetectable		 6djzB-6ciaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es9 ACYL-COA
DEHYDROGENASE

(Paracoccus
denitrificans) 		no annotation 4 TYR A 472
GLN A 427
GLU A 172
ALA A 230
 None
 1.07A 6djzB-6es9A:
undetectable		 6djzB-6es9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3

(Homo sapiens) 		no annotation 4 TYR A 114
GLN A 190
GLU A  58
ALA A  98
 None
NAP  A 401 (-3.8A)
None
None
 1.24A 6djzB-6f2uA:
undetectable		 6djzB-6f2uA:
undetectable