SIMILAR PATTERNS OF AMINO ACIDS FOR 6DJZ_B_GMJB301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (ALPHA
SUBUNIT)

(Klebsiella
aerogenes) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 ILE C 284
THR C 341
VAL C 543
THR C 270
LEU C 294
 None
 1.34A 6djzB-1a5lC:
0.0		 6djzB-1a5lC:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (ALPHA
SUBUNIT)

(Klebsiella
aerogenes) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 LEU C 260
ILE C 284
THR C 341
VAL C 543
THR C 270
 None
 1.16A 6djzB-1a5lC:
0.0		 6djzB-1a5lC:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhe POLYGALACTURONASE

(Pectobacterium
carotovorum) 		PF00295
(Glyco_hydro_28) 		5 LEU A 169
SER A  54
ILE A 103
PHE A  82
THR A  26
 None
 1.39A 6djzB-1bheA:
0.0		 6djzB-1bheA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bk6 KARYOPHERIN ALPHA

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 LEU A 182
THR A 166
VAL A 170
THR A 238
LEU A 239
 None
 1.27A 6djzB-1bk6A:
undetectable		 6djzB-1bk6A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq2 MALIC ENZYME

(Columba livia) 		PF00390
(malic)
PF03949
(Malic_M) 		5 LEU A 266
SER A 285
THR A 494
VAL A 470
LEU A 317
 None
 1.39A 6djzB-1gq2A:
0.1		 6djzB-1gq2A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k82 FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE

(Escherichia
coli) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		5 LEU A 142
SER A 172
ILE A 153
THR A 260
LEU A 196
 None
 1.18A 6djzB-1k82A:
0.0		 6djzB-1k82A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd5 CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		5 LEU A  39
ILE A  62
PHE A 143
HIS A  61
LEU A  45
 None
 1.34A 6djzB-1pd5A:
0.0		 6djzB-1pd5A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v29 NITRILE HYDRATASE A
CHAIN
NITRILE HYDRATASE B
CHAIN

(Bacillus
smithii;
Bacillus
smithii) 		PF02979
(NHase_alpha)
PF02211
(NHase_beta) 		5 TYR B 164
SER A 175
ILE B 217
PHE A 179
VAL A 177
 None
 1.40A 6djzB-1v29B:
undetectable		 6djzB-1v29B:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2x TRNA (GM18)
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00588
(SpoU_methylase)
PF12105
(SpoU_methylas_C) 		5 TYR A 113
ILE A 140
VAL A 128
THR A 117
LEU A  23
 None
 1.25A 6djzB-1v2xA:
undetectable		 6djzB-1v2xA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF04095
(NAPRTase) 		5 TYR A  34
LEU A 380
ILE A 129
HIS A  20
TRP A 234
 None
 1.38A 6djzB-1vlpA:
0.0		 6djzB-1vlpA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yew PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE
SUBUNIT C2

(Methylococcus
capsulatus;
Methylococcus
capsulatus) 		PF02461
(AMO)
PF04896
(AmoC) 		5 SER C 172
ILE C 163
PHE C  85
TRP C  89
THR B 112
 None
 1.30A 6djzB-1yewC:
undetectable		 6djzB-1yewC:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aw5 NADP-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		5 LEU A 256
SER A 275
THR A 481
VAL A 457
LEU A 307
 None
 1.28A 6djzB-2aw5A:
undetectable		 6djzB-2aw5A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi0 HYPOTHETICAL PROTEIN
RV0216

(Mycobacterium
tuberculosis) 		no annotation 5 ILE A  78
THR A  85
VAL A  88
THR A 230
LEU A 229
 None
 1.34A 6djzB-2bi0A:
undetectable		 6djzB-2bi0A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btj GREEN TO RED
PHOTOCONVERTIBLE
GPF-LIKE PROTEIN
EOSFP

(Lobophyllia
hemprichii) 		PF01353
(GFP) 		5 TRP A  89
LEU A  93
HIS A 194
THR A  58
LEU A  57
 IEY  A  64 ( 4.0A)
None
IEY  A  64 ( 3.6A)
None
NFA  A  61 ( 4.4A)
 1.18A 6djzB-2btjA:
undetectable		 6djzB-2btjA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Gallus gallus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		5 TYR A 615
LEU A 631
PHE A 603
VAL A 460
TRP A 604
 None
 1.09A 6djzB-2fafA:
undetectable		 6djzB-2fafA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		5 TYR A  64
LEU A  68
ILE A 156
PHE A 151
VAL A 190
 None
 1.21A 6djzB-2genA:
undetectable		 6djzB-2genA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw3 KAEDE

(Trachyphyllia
geoffroyi) 		PF01353
(GFP) 		5 TRP A  89
LEU A  93
HIS A 194
THR A  58
LEU A  57
 CR8  A  63 ( 4.0A)
None
CR8  A  63 ( 3.6A)
None
None
 1.19A 6djzB-2gw3A:
undetectable		 6djzB-2gw3A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw4 KAEDE
KAEDE

(Trachyphyllia
geoffroyi;
Trachyphyllia
geoffroyi) 		PF01353
(GFP)
PF01353
(GFP) 		5 TRP B  89
LEU B  93
HIS B 194
THR A  58
LEU A  57
 RC7  B  63 ( 4.1A)
None
RC7  B  63 ( 3.6A)
None
NFA  A  61 ( 4.4A)
 1.18A 6djzB-2gw4B:
undetectable		 6djzB-2gw4B:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE

(Streptococcus
pneumoniae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 ILE A 123
PHE A 355
HIS A 119
THR A 350
VAL A  85
 None
 1.31A 6djzB-2gz3A:
undetectable		 6djzB-2gz3A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcu 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT

(Streptococcus
mutans) 		PF00694
(Aconitase_C) 		5 LEU A  91
PHE A   4
VAL A 141
THR A  74
LEU A  14
 None
 1.17A 6djzB-2hcuA:
undetectable		 6djzB-2hcuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iod DIHYDROFLAVONOL
4-REDUCTASE

(Vitis vinifera) 		PF01370
(Epimerase) 		5 LEU A 231
SER A 200
ILE A 198
HIS A  47
THR A 318
 None
 1.21A 6djzB-2iodA:
undetectable		 6djzB-2iodA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA

(Vibrio cholerae) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		5 TYR A  44
LEU A  47
ILE A 270
VAL A 277
THR A 246
 None
 1.17A 6djzB-2nx9A:
undetectable		 6djzB-2nx9A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA

(Vibrio cholerae) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		5 TYR A  44
LEU A  47
SER A 236
ILE A 270
THR A 246
 None
 1.34A 6djzB-2nx9A:
undetectable		 6djzB-2nx9A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ose PROBABLE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Mimivirus) 		PF00160
(Pro_isomerase) 		5 TYR A 107
LEU A   8
ILE A 112
PHE A 116
VAL A 168
 None
 1.17A 6djzB-2oseA:
undetectable		 6djzB-2oseA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2

(Homo sapiens) 		PF00797
(Acetyltransf_2) 		5 LEU A 135
SER A 127
PHE A 244
VAL A 231
LEU A 109
 None
UNX  A1009 ( 4.0A)
None
None
None
 1.12A 6djzB-2pfrA:
undetectable		 6djzB-2pfrA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmt GLUTATHIONE
TRANSFERASE

(Proteus
mirabilis) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 ILE A  16
PHE A  25
THR A 197
THR A 160
LEU A 161
 None
 1.37A 6djzB-2pmtA:
undetectable		 6djzB-2pmtA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyg RIBULOSE
BISPHOSPHATE
CARBOXYLASE-LIKE
PROTEIN 2

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 LEU A 310
ILE A  22
PHE A  26
HIS A 100
VAL A 121
 None
 1.28A 6djzB-2qygA:
undetectable		 6djzB-2qygA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rex PLEXIN-B1
RHO-RELATED
GTP-BINDING PROTEIN
RHO6

(Homo sapiens;
Homo sapiens) 		PF08337
(Plexin_cytopl)
PF00071
(Ras) 		5 LEU A1751
ILE A1777
THR A1823
VAL B  77
LEU A1772
 None
UNX  A  11 ( 4.8A)
None
None
None
 1.33A 6djzB-2rexA:
undetectable		 6djzB-2rexA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		5 LEU G1040
ILE G1053
HIS G1055
THR G1063
THR G 859
 None
 1.23A 6djzB-2uv8G:
undetectable		 6djzB-2uv8G:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 549
ILE A 480
HIS A 481
THR A 556
LEU A 555
 None
 1.11A 6djzB-2vk4A:
undetectable		 6djzB-2vk4A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w20 SIALIDASE A

(Streptococcus
pneumoniae) 		PF13088
(BNR_2) 		5 LEU A 359
PHE A 784
VAL A 726
THR A 572
LEU A 420
 None
 1.30A 6djzB-2w20A:
undetectable		 6djzB-2w20A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn9 POTASSIUM-TRANSPORTI
NG ATPASE ALPHA
CHAIN 1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF09040
(H-K_ATPase_N)
PF13246
(Cation_ATPase) 		5 TYR A 799
LEU A 809
ILE A 816
PHE A 990
THR A 823
 None
 1.30A 6djzB-2yn9A:
2.3		 6djzB-2yn9A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da1 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Bacillus
halodurans) 		PF01266
(DAO)
PF16901
(DAO_C) 		5 TYR A 444
LEU A 443
PHE A 491
VAL A 512
LEU A 452
 None
 1.40A 6djzB-3da1A:
undetectable		 6djzB-3da1A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9z PURINE-NUCLEOSIDE
PHOSPHORYLASE

(Schistosoma
mansoni) 		PF01048
(PNP_UDP_1) 		5 LEU A  40
ILE A 280
PHE A 185
VAL A 189
LEU A 113
 None
 1.27A 6djzB-3e9zA:
undetectable		 6djzB-3e9zA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejn SUSD HOMOLOG

(Bacteroides
fragilis) 		PF12771
(SusD-like_2) 		5 TYR A 116
THR A  57
TRP A 451
THR A 198
LEU A 199
 None
None
PG4  A   1 (-3.9A)
None
None
 1.34A 6djzB-3ejnA:
undetectable		 6djzB-3ejnA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III

(Burkholderia
pseudomallei) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 TYR A 124
LEU A 128
ILE A  15
VAL A  76
THR A 147
 None
 1.00A 6djzB-3gweA:
undetectable		 6djzB-3gweA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Shewanella
denitrificans) 		PF01380
(SIS) 		5 LEU A  22
SER A 173
ILE A 296
HIS A 293
LEU A 161
 None
 1.34A 6djzB-3hbaA:
undetectable		 6djzB-3hbaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hea ARYLESTERASE

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		5 LEU A 147
SER A  94
PHE A 125
HIS A 251
VAL A 121
 None
EEE  A 300 (-1.4A)
None
EEE  A 300 (-4.3A)
None
 1.33A 6djzB-3heaA:
undetectable		 6djzB-3heaA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		5 SER A 343
ILE A 135
VAL A 173
THR A 282
LEU A 261
 None
 1.31A 6djzB-3hjrA:
undetectable		 6djzB-3hjrA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4t DIPHTHINE SYNTHASE

(Entamoeba
histolytica) 		PF00590
(TP_methylase) 		5 LEU A  80
PHE A  95
HIS A 109
THR A  16
LEU A  20
 None
 1.35A 6djzB-3i4tA:
undetectable		 6djzB-3i4tA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ide CAPSID PROTEIN VP2

(Infectious
pancreatic
necrosis virus) 		PF01766
(Birna_VP2) 		5 TYR A 372
LEU A  98
THR A 298
VAL A 233
THR A  85
 None
 1.23A 6djzB-3ideA:
undetectable		 6djzB-3ideA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxl RAS-SPECIFIC GUANINE
NUCLEOTIDE-RELEASING
FACTOR RALGPS1

(Homo sapiens) 		PF00617
(RasGEF) 		5 TYR A 249
LEU A 252
ILE A 200
HIS A 139
VAL A 101
 None
 1.32A 6djzB-3qxlA:
undetectable		 6djzB-3qxlA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		5 LEU A 245
SER A 270
THR A 308
THR A 240
LEU A 239
 None
 1.38A 6djzB-3ua4A:
undetectable		 6djzB-3ua4A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vc7 PUTATIVE
OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 LEU A 123
ILE A  87
VAL A 225
THR A  37
LEU A  58
 None
 1.37A 6djzB-3vc7A:
undetectable		 6djzB-3vc7A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr1 PEPTIDE CHAIN
RELEASE FACTOR 3

(Desulfovibrio
vulgaris) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF16658
(RF3_C) 		5 TYR A 182
LEU A 229
ILE A 206
HIS A 207
LEU A 185
 None
 1.35A 6djzB-3vr1A:
undetectable		 6djzB-3vr1A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egv ACETYL-COA
ACETYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		no annotation 5 TYR A 407
LEU A 283
SER A 104
ILE A 375
LEU A 391
 None
 1.38A 6djzB-4egvA:
undetectable		 6djzB-4egvA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egv ACETYL-COA
ACETYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		no annotation 5 TYR A 407
LEU A 283
SER A 104
ILE A 375
THR A  61
 None
 1.25A 6djzB-4egvA:
undetectable		 6djzB-4egvA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4es9 EPF

(Streptococcus
pyogenes) 		no annotation 5 TYR A 151
LEU A  62
ILE A 146
THR A 301
THR A 252
 None
 1.24A 6djzB-4es9A:
undetectable		 6djzB-4es9A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgm AMINOPEPTIDASE N
FAMILY PROTEIN

(Idiomarina
loihiensis) 		PF05299
(Peptidase_M61)
PF13180
(PDZ_2) 		5 ILE A   6
THR A 140
VAL A 138
TRP A 152
LEU A  15
 None
 1.32A 6djzB-4fgmA:
undetectable		 6djzB-4fgmA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggp TRANS-2-ENOYL-COA
REDUCTASE

(Treponema
denticola) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		5 TYR A 228
LEU A 226
ILE A 311
THR A  31
LEU A  52
 None
 1.38A 6djzB-4ggpA:
undetectable		 6djzB-4ggpA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grc PUTATIVE MEMBRANE
PROTEIN

(Streptomyces
coelicolor) 		PF04261
(Dyp_perox) 		5 TRP A 213
LEU A 273
SER A 214
PHE A  81
HIS A  77
 None
 1.20A 6djzB-4grcA:
undetectable		 6djzB-4grcA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grc PUTATIVE MEMBRANE
PROTEIN

(Streptomyces
coelicolor) 		PF04261
(Dyp_perox) 		5 TRP A 213
SER A 214
PHE A  81
HIS A  77
VAL A 211
 None
 1.28A 6djzB-4grcA:
undetectable		 6djzB-4grcA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gs1 DYP-TYPE PEROXIDASE

(Thermobifida
cellulosilytica) 		PF04261
(Dyp_perox) 		5 TRP A 213
SER A 214
PHE A  89
HIS A  85
VAL A 211
 None
 1.34A 6djzB-4gs1A:
undetectable		 6djzB-4gs1A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz8 BETA-GLUCOSIDASE

(uncultured
bacterium) 		PF00232
(Glyco_hydro_1) 		5 TYR A 297
LEU A 308
ILE A 320
HIS A 238
THR A 200
 None
 1.33A 6djzB-4hz8A:
undetectable		 6djzB-4hz8A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l08 HYDROLASE,
ISOCHORISMATASE
FAMILY

(Pseudomonas
putida) 		no annotation 5 TYR B  72
LEU B  83
SER B 120
ILE B  70
THR B 153
 None
 1.27A 6djzB-4l08B:
undetectable		 6djzB-4l08B:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le7 PYOCIN L1

(Pseudomonas
aeruginosa) 		PF01453
(B_lectin) 		5 TRP A 251
SER A 250
ILE A 248
VAL A 235
LEU A  26
 None
EDO  A 305 (-3.9A)
None
None
None
 1.34A 6djzB-4le7A:
undetectable		 6djzB-4le7A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5c CARGO-TRANSPORT
PROTEIN YPP1

(Saccharomyces
cerevisiae) 		no annotation 5 TYR A 190
LEU A 193
SER A 432
ILE A  56
LEU A 187
 None
 1.39A 6djzB-4n5cA:
undetectable		 6djzB-4n5cA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nv4 SIGNAL PEPTIDASE I

(Bacillus
anthracis) 		PF00717
(Peptidase_S24) 		5 TYR A 109
LEU A 110
SER A 155
ILE A  84
PHE A 126
 None
 1.04A 6djzB-4nv4A:
undetectable		 6djzB-4nv4A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5w CALCIUM-BINDING
MITOCHONDRIAL
CARRIER PROTEIN
ARALAR2,CALCIUM-BIND
ING MITOCHONDRIAL
CARRIER PROTEIN
ARALAR2

(Homo sapiens) 		no annotation 5 ILE A 650
PHE A  99
THR A 119
VAL A 115
LEU A  45
 None
 1.26A 6djzB-4p5wA:
undetectable		 6djzB-4p5wA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q05 ESTERASE E25

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 LEU A 335
SER A 146
ILE A 136
THR A 130
LEU A 210
 None
 1.39A 6djzB-4q05A:
undetectable		 6djzB-4q05A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb7 UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF13149
(Mfa_like_1) 		5 TYR A 347
LEU A 307
ILE A 191
VAL A 148
THR A 338
 None
 1.23A 6djzB-4qb7A:
undetectable		 6djzB-4qb7A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlb PROBABLE GLYCOGEN
[STARCH] SYNTHASE

(Caenorhabditis
elegans) 		PF05693
(Glycogen_syn) 		5 LEU A 334
SER A 401
THR A 467
THR A 408
LEU A 411
 None
 1.40A 6djzB-4qlbA:
undetectable		 6djzB-4qlbA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2

(Danio rerio) 		PF00067
(p450) 		5 LEU A 250
ILE A 245
THR A 215
THR A 204
LEU A 202
 None
 1.21A 6djzB-4r20A:
undetectable		 6djzB-4r20A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra6 L-ASPARAGINASE

(Pyrococcus
furiosus) 		PF00710
(Asparaginase) 		5 LEU A 124
PHE A 163
HIS A  81
THR A  85
LEU A  25
 None
 1.39A 6djzB-4ra6A:
undetectable		 6djzB-4ra6A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rd8 UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 5 LEU A  73
ILE A 200
HIS A 199
THR A  39
VAL A  42
 None
 1.29A 6djzB-4rd8A:
undetectable		 6djzB-4rd8A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwr STAGE II SPORULATION
PROTEIN D

(Bacillus
anthracis) 		PF08486
(SpoIID) 		5 TRP A 277
PHE A 218
THR A 288
VAL A 286
THR A 260
 None
 1.21A 6djzB-4rwrA:
undetectable		 6djzB-4rwrA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpg DTDP-4-DEHYDRORHAMNO
SE REDUCTASE

(Streptococcus
pyogenes) 		PF04321
(RmlD_sub_bind) 		5 TYR A  55
LEU A  15
ILE A   2
THR A 199
LEU A 198
 MPD  A 301 (-4.6A)
None
None
MPD  A 301 ( 3.2A)
None
 1.26A 6djzB-4wpgA:
undetectable		 6djzB-4wpgA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yh2 GLUTATHIONE S
TRANSFERASE E6

(Drosophila
melanogaster) 		PF13417
(GST_N_3)
PF14497
(GST_C_3) 		5 LEU A 192
ILE A 152
VAL A 107
THR A 158
LEU A  85
 None
 1.26A 6djzB-4yh2A:
undetectable		 6djzB-4yh2A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yr1 ALKALINE PHOSPHATASE

(Escherichia
coli) 		PF00245
(Alk_phosphatase) 		5 LEU A  48
ILE A 307
VAL A 202
THR A 362
LEU A 363
 None
 1.22A 6djzB-4yr1A:
undetectable		 6djzB-4yr1A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyb HA1

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 LEU A  62
ILE A 228
HIS A 182
VAL A 200
LEU A  98
 None
 1.39A 6djzB-4yybA:
undetectable		 6djzB-4yybA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aoc ESTERASE

(Thermogutta
terrifontis) 		PF07859
(Abhydrolase_3) 		5 LEU A 240
SER A 126
PHE A 251
HIS A 248
THR A 223
 None
LEA  A1283 (-2.3A)
None
LEA  A1283 (-4.0A)
EDO  A1286 ( 4.9A)
 1.29A 6djzB-5aocA:
undetectable		 6djzB-5aocA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ar1 CELL DIVISION
CONTROL PROTEIN 11

(Saccharomyces
cerevisiae) 		PF00735
(Septin) 		5 TYR A 114
LEU A 287
PHE A 156
THR A  90
VAL A  28
 None
 1.38A 6djzB-5ar1A:
undetectable		 6djzB-5ar1A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1q U14 PROTEIN

(Human
betaherpesvirus
6B) 		PF04637
(Herpes_pp85) 		5 LEU A 122
ILE A 159
PHE A 166
THR A 194
THR A 240
 None
 1.13A 6djzB-5b1qA:
undetectable		 6djzB-5b1qA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2o CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Francisella
tularensis) 		no annotation 5 TYR A  24
LEU A  33
ILE A1183
HIS A1177
LEU A   6
 None
None
None
None
EDO  A1725 ( 4.5A)
 1.26A 6djzB-5b2oA:
1.2		 6djzB-5b2oA:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE

(Methanospirillum
hungatei) 		PF00485
(PRK) 		5 LEU A 130
ILE A 119
THR A 114
VAL A  17
LEU A  79
 None
 1.35A 6djzB-5b3fA:
undetectable		 6djzB-5b3fA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfw SINGLE CHAIN FV
FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		5 TYR H 602
LEU H 612
PHE H 152
HIS H 199
LEU H 598
 None
 1.10A 6djzB-5dfwH:
undetectable		 6djzB-5dfwH:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e44 FNR REGULATOR

(Aliivibrio
fischeri) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 LEU A 239
ILE A 231
PHE A 181
THR A 194
LEU A 214
 None
 1.06A 6djzB-5e44A:
3.8		 6djzB-5e44A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4o CAPSID PROTEIN VP1

(Norwalk virus) 		PF08435
(Calici_coat_C) 		5 ILE A 283
PHE A 327
VAL A 391
THR A 238
LEU A 237
 None
 1.10A 6djzB-5f4oA:
undetectable		 6djzB-5f4oA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO

(Homo sapiens) 		PF12933
(FTO_NTD)
PF12934
(FTO_CTD) 		5 TYR A 295
LEU A 289
PHE A  69
HIS A 321
VAL A  65
 AKG  A 603 (-4.6A)
None
None
None
None
 1.36A 6djzB-5f8pA:
4.4		 6djzB-5f8pA:
17.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hk2 SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1

(Homo sapiens) 		PF04622
(ERG2_Sigma1R) 		7 SER A 117
PHE A 133
HIS A 154
THR A 160
VAL A 162
TRP A 164
LEU A 186
 61V  A 301 (-2.9A)
None
61V  A 301 ( 4.1A)
None
None
None
None
 1.03A 6djzB-5hk2A:
35.1		 6djzB-5hk2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hk2 SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1

(Homo sapiens) 		PF04622
(ERG2_Sigma1R) 		12 TRP A  89
TYR A 103
LEU A 105
SER A 117
ILE A 124
PHE A 133
HIS A 154
THR A 160
VAL A 162
TRP A 164
THR A 181
LEU A 182
 None
61V  A 301 ( 4.3A)
None
61V  A 301 (-2.9A)
61V  A 301 ( 4.7A)
None
61V  A 301 ( 4.1A)
None
None
None
61V  A 301 ( 4.7A)
None
 0.63A 6djzB-5hk2A:
35.1		 6djzB-5hk2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i68 ALCOHOL OXIDASE 1

(Komagataella
pastoris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A 589
THR A 617
VAL A 613
THR A 628
LEU A 631
 None
FAD  A 702 (-3.4A)
None
None
None
 1.37A 6djzB-5i68A:
undetectable		 6djzB-5i68A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5il7 RAB FAMILY PROTEIN

(Chlorobaculum
tepidum) 		PF12799
(LRR_4)
PF13516
(LRR_6) 		5 LEU A  70
SER A  61
ILE A  56
VAL A   6
LEU A 106
 None
 1.39A 6djzB-5il7A:
undetectable		 6djzB-5il7A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf2 PREDICTED
ACETYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF00583
(Acetyltransf_1) 		5 TRP A 193
LEU A 250
PHE A 200
HIS A 120
THR A 289
 PO4  A 405 (-3.7A)
None
None
None
None
 1.40A 6djzB-5kf2A:
undetectable		 6djzB-5kf2A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA

(Methylobacillus
flagellatus) 		PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		5 TYR C  40
LEU C  43
ILE C 266
VAL C 273
THR C 242
 None
 1.21A 6djzB-5ks8C:
undetectable		 6djzB-5ks8C:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA

(Methylobacillus
flagellatus) 		PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		5 TYR C  40
LEU C  43
SER C 232
ILE C 266
THR C 242
 None
 1.30A 6djzB-5ks8C:
undetectable		 6djzB-5ks8C:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1

(Bos taurus) 		PF00146
(NADHdh) 		5 LEU H 285
ILE H 187
PHE H 270
THR H 238
THR H 145
 None
 1.23A 6djzB-5lc5H:
undetectable		 6djzB-5lc5H:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF06444
(NADH_dehy_S2_C) 		5 LEU N 248
ILE N 178
THR N 119
THR N 226
LEU N 230
 None
 1.34A 6djzB-5lc5N:
undetectable		 6djzB-5lc5N:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lk7 VP1

(Slow bee
paralysis virus) 		PF08762
(CRPV_capsid) 		5 TYR A 221
LEU A 105
SER A  96
ILE A  91
LEU A  72
 None
 0.96A 6djzB-5lk7A:
undetectable		 6djzB-5lk7A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1m INSULIN RECEPTOR
SUBSTRATE 1

(Homo sapiens) 		PF02174
(IRS) 		5 TRP A 164
LEU A 208
ILE A 223
VAL A 166
LEU A 254
 None
 1.31A 6djzB-5u1mA:
3.2		 6djzB-5u1mA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v3v GLOBIN

(Bacillus
anthracis) 		PF01152
(Bac_globin) 		5 LEU A  73
ILE A  82
PHE A  39
VAL A  29
LEU A 117
 HEM  A 201 (-4.2A)
HEM  A 201 (-4.1A)
HEM  A 201 (-4.0A)
None
None
 1.31A 6djzB-5v3vA:
undetectable		 6djzB-5v3vA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgx FLAVIN-DEPENDENT
HALOGENASE

(Malbranchea
aurantiaca) 		PF04820
(Trp_halogenase) 		5 TRP A  90
ILE A  47
THR A 418
THR A  83
LEU A 140
 None
FAD  A 701 (-4.9A)
None
None
None
 1.40A 6djzB-5wgxA:
undetectable		 6djzB-5wgxA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 5 LEU A1285
SER A1359
ILE A1111
PHE A1049
THR A1054
 None
 1.24A 6djzB-5wlhA:
undetectable		 6djzB-5wlhA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd0 GLUCANASE

(Paenibacillus
sp. X4) 		PF01270
(Glyco_hydro_8) 		5 TYR A 292
LEU A 264
THR A 381
VAL A 377
TRP A 373
 None
 1.07A 6djzB-5xd0A:
undetectable		 6djzB-5xd0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgj PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM

(Homo sapiens) 		no annotation 5 LEU A 445
ILE A 338
VAL A 376
THR A 358
LEU A 456
 None
 1.36A 6djzB-5xgjA:
undetectable		 6djzB-5xgjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES

(Staphylococcus
aureus) 		no annotation 5 LEU A 394
ILE A 351
THR A 465
VAL A 469
LEU A 525
 None
 1.18A 6djzB-5xt3A:
undetectable		 6djzB-5xt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 5 LEU A 241
HIS A 338
VAL A 272
THR A 258
LEU A 257
 None
None
DL1  A 601 ( 4.8A)
None
None
 1.27A 6djzB-6bfnA:
undetectable		 6djzB-6bfnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c93 CYTOCHROME P450 4B1

(Oryctolagus
cuniculus) 		no annotation 5 SER A 320
THR A 316
VAL A 179
TRP A 163
LEU A 478
 None
 1.34A 6djzB-6c93A:
undetectable		 6djzB-6c93A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		no annotation
no annotation 		5 TYR E  70
LEU H  61
ILE H   8
THR H  40
VAL H  43
 None
 1.26A 6djzB-6cfwE:
undetectable		 6djzB-6cfwE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f34 AMINO ACID
TRANSPORTER

(Geobacillus
kaustophilus) 		no annotation 5 SER A  64
PHE A 219
VAL A 222
THR A 265
LEU A 266
 None
 1.32A 6djzB-6f34A:
undetectable		 6djzB-6f34A:
undetectable