SIMILAR PATTERNS OF AMINO ACIDS FOR 6DJZ_B_GMJB301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (ALPHA
SUBUNIT)

(Klebsiella
aerogenes) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 ILE C 284
THR C 341
VAL C 543
THR C 270
LEU C 294
 None
 1.34A 6djzB-1a5lC:
0.0		 6djzB-1a5lC:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (ALPHA
SUBUNIT)

(Klebsiella
aerogenes) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 LEU C 260
ILE C 284
THR C 341
VAL C 543
THR C 270
 None
 1.16A 6djzB-1a5lC:
0.0		 6djzB-1a5lC:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhe POLYGALACTURONASE

(Pectobacterium
carotovorum) 		PF00295
(Glyco_hydro_28) 		5 LEU A 169
SER A  54
ILE A 103
PHE A  82
THR A  26
 None
 1.39A 6djzB-1bheA:
0.0		 6djzB-1bheA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bk6 KARYOPHERIN ALPHA

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 LEU A 182
THR A 166
VAL A 170
THR A 238
LEU A 239
 None
 1.27A 6djzB-1bk6A:
undetectable		 6djzB-1bk6A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq2 MALIC ENZYME

(Columba livia) 		PF00390
(malic)
PF03949
(Malic_M) 		5 LEU A 266
SER A 285
THR A 494
VAL A 470
LEU A 317
 None
 1.39A 6djzB-1gq2A:
0.1		 6djzB-1gq2A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k82 FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE

(Escherichia
coli) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		5 LEU A 142
SER A 172
ILE A 153
THR A 260
LEU A 196
 None
 1.18A 6djzB-1k82A:
0.0		 6djzB-1k82A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd5 CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		5 LEU A  39
ILE A  62
PHE A 143
HIS A  61
LEU A  45
 None
 1.34A 6djzB-1pd5A:
0.0		 6djzB-1pd5A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v29 NITRILE HYDRATASE A
CHAIN
NITRILE HYDRATASE B
CHAIN

(Bacillus
smithii;
Bacillus
smithii) 		PF02979
(NHase_alpha)
PF02211
(NHase_beta) 		5 TYR B 164
SER A 175
ILE B 217
PHE A 179
VAL A 177
 None
 1.40A 6djzB-1v29B:
undetectable		 6djzB-1v29B:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2x TRNA (GM18)
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00588
(SpoU_methylase)
PF12105
(SpoU_methylas_C) 		5 TYR A 113
ILE A 140
VAL A 128
THR A 117
LEU A  23
 None
 1.25A 6djzB-1v2xA:
undetectable		 6djzB-1v2xA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF04095
(NAPRTase) 		5 TYR A  34
LEU A 380
ILE A 129
HIS A  20
TRP A 234
 None
 1.38A 6djzB-1vlpA:
0.0		 6djzB-1vlpA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yew PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE
SUBUNIT C2

(Methylococcus
capsulatus;
Methylococcus
capsulatus) 		PF02461
(AMO)
PF04896
(AmoC) 		5 SER C 172
ILE C 163
PHE C  85
TRP C  89
THR B 112
 None
 1.30A 6djzB-1yewC:
undetectable		 6djzB-1yewC:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aw5 NADP-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		5 LEU A 256
SER A 275
THR A 481
VAL A 457
LEU A 307
 None
 1.28A 6djzB-2aw5A:
undetectable		 6djzB-2aw5A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi0 HYPOTHETICAL PROTEIN
RV0216

(Mycobacterium
tuberculosis) 		no annotation 5 ILE A  78
THR A  85
VAL A  88
THR A 230
LEU A 229
 None
 1.34A 6djzB-2bi0A:
undetectable		 6djzB-2bi0A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btj GREEN TO RED
PHOTOCONVERTIBLE
GPF-LIKE PROTEIN
EOSFP

(Lobophyllia
hemprichii) 		PF01353
(GFP) 		5 TRP A  89
LEU A  93
HIS A 194
THR A  58
LEU A  57
 IEY  A  64 ( 4.0A)
None
IEY  A  64 ( 3.6A)
None
NFA  A  61 ( 4.4A)
 1.18A 6djzB-2btjA:
undetectable		 6djzB-2btjA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Gallus gallus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		5 TYR A 615
LEU A 631
PHE A 603
VAL A 460
TRP A 604
 None
 1.09A 6djzB-2fafA:
undetectable		 6djzB-2fafA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		5 TYR A  64
LEU A  68
ILE A 156
PHE A 151
VAL A 190
 None
 1.21A 6djzB-2genA:
undetectable		 6djzB-2genA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw3 KAEDE

(Trachyphyllia
geoffroyi) 		PF01353
(GFP) 		5 TRP A  89
LEU A  93
HIS A 194
THR A  58
LEU A  57
 CR8  A  63 ( 4.0A)
None
CR8  A  63 ( 3.6A)
None
None
 1.19A 6djzB-2gw3A:
undetectable		 6djzB-2gw3A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw4 KAEDE
KAEDE

(Trachyphyllia
geoffroyi;
Trachyphyllia
geoffroyi) 		PF01353
(GFP)
PF01353
(GFP) 		5 TRP B  89
LEU B  93
HIS B 194
THR A  58
LEU A  57
 RC7  B  63 ( 4.1A)
None
RC7  B  63 ( 3.6A)
None
NFA  A  61 ( 4.4A)
 1.18A 6djzB-2gw4B:
undetectable		 6djzB-2gw4B:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE

(Streptococcus
pneumoniae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 ILE A 123
PHE A 355
HIS A 119
THR A 350
VAL A  85
 None
 1.31A 6djzB-2gz3A:
undetectable		 6djzB-2gz3A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcu 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT

(Streptococcus
mutans) 		PF00694
(Aconitase_C) 		5 LEU A  91
PHE A   4
VAL A 141
THR A  74
LEU A  14
 None
 1.17A 6djzB-2hcuA:
undetectable		 6djzB-2hcuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iod DIHYDROFLAVONOL
4-REDUCTASE

(Vitis vinifera) 		PF01370
(Epimerase) 		5 LEU A 231
SER A 200
ILE A 198
HIS A  47
THR A 318
 None
 1.21A 6djzB-2iodA:
undetectable		 6djzB-2iodA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA

(Vibrio cholerae) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		5 TYR A  44
LEU A  47
ILE A 270
VAL A 277
THR A 246
 None
 1.17A 6djzB-2nx9A:
undetectable		 6djzB-2nx9A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA

(Vibrio cholerae) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		5 TYR A  44
LEU A  47
SER A 236
ILE A 270
THR A 246
 None
 1.34A 6djzB-2nx9A:
undetectable		 6djzB-2nx9A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ose PROBABLE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Mimivirus) 		PF00160
(Pro_isomerase) 		5 TYR A 107
LEU A   8
ILE A 112
PHE A 116
VAL A 168
 None
 1.17A 6djzB-2oseA:
undetectable		 6djzB-2oseA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2

(Homo sapiens) 		PF00797
(Acetyltransf_2) 		5 LEU A 135
SER A 127
PHE A 244
VAL A 231
LEU A 109
 None
UNX  A1009 ( 4.0A)
None
None
None
 1.12A 6djzB-2pfrA:
undetectable		 6djzB-2pfrA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmt GLUTATHIONE
TRANSFERASE

(Proteus
mirabilis) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 ILE A  16
PHE A  25
THR A 197
THR A 160
LEU A 161
 None
 1.37A 6djzB-2pmtA:
undetectable		 6djzB-2pmtA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyg RIBULOSE
BISPHOSPHATE
CARBOXYLASE-LIKE
PROTEIN 2

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 LEU A 310
ILE A  22
PHE A  26
HIS A 100
VAL A 121
 None
 1.28A 6djzB-2qygA:
undetectable		 6djzB-2qygA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rex PLEXIN-B1
RHO-RELATED
GTP-BINDING PROTEIN
RHO6

(Homo sapiens;
Homo sapiens) 		PF08337
(Plexin_cytopl)
PF00071
(Ras) 		5 LEU A1751
ILE A1777
THR A1823
VAL B  77
LEU A1772
 None
UNX  A  11 ( 4.8A)
None
None
None
 1.33A 6djzB-2rexA:
undetectable		 6djzB-2rexA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		5 LEU G1040
ILE G1053
HIS G1055
THR G1063
THR G 859
 None
 1.23A 6djzB-2uv8G:
undetectable		 6djzB-2uv8G:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 549
ILE A 480
HIS A 481
THR A 556
LEU A 555
 None
 1.11A 6djzB-2vk4A:
undetectable		 6djzB-2vk4A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w20 SIALIDASE A

(Streptococcus
pneumoniae) 		PF13088
(BNR_2) 		5 LEU A 359
PHE A 784
VAL A 726
THR A 572
LEU A 420
 None
 1.30A 6djzB-2w20A:
undetectable		 6djzB-2w20A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn9 POTASSIUM-TRANSPORTI
NG ATPASE ALPHA
CHAIN 1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF09040
(H-K_ATPase_N)
PF13246
(Cation_ATPase) 		5 TYR A 799
LEU A 809
ILE A 816
PHE A 990
THR A 823
 None
 1.30A 6djzB-2yn9A:
2.3		 6djzB-2yn9A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da1 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Bacillus
halodurans) 		PF01266
(DAO)
PF16901
(DAO_C) 		5 TYR A 444
LEU A 443
PHE A 491
VAL A 512
LEU A 452
 None
 1.40A 6djzB-3da1A:
undetectable		 6djzB-3da1A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9z PURINE-NUCLEOSIDE
PHOSPHORYLASE

(Schistosoma
mansoni) 		PF01048
(PNP_UDP_1) 		5 LEU A  40
ILE A 280
PHE A 185
VAL A 189
LEU A 113
 None
 1.27A 6djzB-3e9zA:
undetectable		 6djzB-3e9zA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejn SUSD HOMOLOG

(Bacteroides
fragilis) 		PF12771
(SusD-like_2) 		5 TYR A 116
THR A  57
TRP A 451
THR A 198
LEU A 199
 None
None
PG4  A   1 (-3.9A)
None
None
 1.34A 6djzB-3ejnA:
undetectable		 6djzB-3ejnA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III

(Burkholderia
pseudomallei) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 TYR A 124
LEU A 128
ILE A  15
VAL A  76
THR A 147
 None
 1.00A 6djzB-3gweA:
undetectable		 6djzB-3gweA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Shewanella
denitrificans) 		PF01380
(SIS) 		5 LEU A  22
SER A 173
ILE A 296
HIS A 293
LEU A 161
 None
 1.34A 6djzB-3hbaA:
undetectable		 6djzB-3hbaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hea ARYLESTERASE

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		5 LEU A 147
SER A  94
PHE A 125
HIS A 251
VAL A 121
 None
EEE  A 300 (-1.4A)
None
EEE  A 300 (-4.3A)
None
 1.33A 6djzB-3heaA:
undetectable		 6djzB-3heaA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		5 SER A 343
ILE A 135
VAL A 173
THR A 282
LEU A 261
 None
 1.31A 6djzB-3hjrA:
undetectable		 6djzB-3hjrA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4t DIPHTHINE SYNTHASE

(Entamoeba
histolytica) 		PF00590
(TP_methylase) 		5 LEU A  80
PHE A  95
HIS A 109
THR A  16
LEU A  20
 None
 1.35A 6djzB-3i4tA:
undetectable		 6djzB-3i4tA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ide CAPSID PROTEIN VP2

(Infectious
pancreatic
necrosis virus) 		PF01766
(Birna_VP2) 		5 TYR A 372
LEU A  98
THR A 298
VAL A 233
THR A  85
 None
 1.23A 6djzB-3ideA:
undetectable		 6djzB-3ideA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxl RAS-SPECIFIC GUANINE
NUCLEOTIDE-RELEASING
FACTOR RALGPS1

(Homo sapiens) 		PF00617
(RasGEF) 		5 TYR A 249
LEU A 252
ILE A 200
HIS A 139
VAL A 101
 None
 1.32A 6djzB-3qxlA:
undetectable		 6djzB-3qxlA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		5 LEU A 245
SER A 270
THR A 308
THR A 240
LEU A 239
 None
 1.38A 6djzB-3ua4A:
undetectable		 6djzB-3ua4A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vc7 PUTATIVE
OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 LEU A 123
ILE A  87
VAL A 225
THR A  37
LEU A  58
 None
 1.37A 6djzB-3vc7A:
undetectable		 6djzB-3vc7A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr1 PEPTIDE CHAIN
RELEASE FACTOR 3

(Desulfovibrio
vulgaris) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF16658
(RF3_C) 		5 TYR A 182
LEU A 229
ILE A 206
HIS A 207
LEU A 185
 None
 1.35A 6djzB-3vr1A:
undetectable		 6djzB-3vr1A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egv ACETYL-COA
ACETYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		no annotation 5 TYR A 407
LEU A 283
SER A 104
ILE A 375
LEU A 391
 None
 1.38A 6djzB-4egvA:
undetectable		 6djzB-4egvA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egv ACETYL-COA
ACETYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		no annotation 5 TYR A 407
LEU A 283
SER A 104
ILE A 375
THR A  61
 None
 1.25A 6djzB-4egvA:
undetectable		 6djzB-4egvA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4es9 EPF

(Streptococcus
pyogenes) 		no annotation 5 TYR A 151
LEU A  62
ILE A 146
THR A 301
THR A 252
 None
 1.24A 6djzB-4es9A:
undetectable		 6djzB-4es9A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgm AMINOPEPTIDASE N
FAMILY PROTEIN

(Idiomarina
loihiensis) 		PF05299
(Peptidase_M61)
PF13180
(PDZ_2) 		5 ILE A   6
THR A 140
VAL A 138
TRP A 152
LEU A  15
 None
 1.32A 6djzB-4fgmA:
undetectable		 6djzB-4fgmA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggp TRANS-2-ENOYL-COA
REDUCTASE

(Treponema
denticola) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		5 TYR A 228
LEU A 226
ILE A 311
THR A  31
LEU A  52
 None
 1.38A 6djzB-4ggpA:
undetectable		 6djzB-4ggpA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grc PUTATIVE MEMBRANE
PROTEIN

(Streptomyces
coelicolor) 		PF04261
(Dyp_perox) 		5 TRP A 213
LEU A 273
SER A 214
PHE A  81
HIS A  77
 None
 1.20A 6djzB-4grcA:
undetectable		 6djzB-4grcA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grc PUTATIVE MEMBRANE
PROTEIN

(Streptomyces
coelicolor) 		PF04261
(Dyp_perox) 		5 TRP A 213
SER A 214
PHE A  81
HIS A  77
VAL A 211
 None
 1.28A 6djzB-4grcA:
undetectable		 6djzB-4grcA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gs1 DYP-TYPE PEROXIDASE

(Thermobifida
cellulosilytica) 		PF04261
(Dyp_perox) 		5 TRP A 213
SER A 214
PHE A  89
HIS A  85
VAL A 211
 None
 1.34A 6djzB-4gs1A:
undetectable		 6djzB-4gs1A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz8 BETA-GLUCOSIDASE

(uncultured
bacterium) 		PF00232
(Glyco_hydro_1) 		5 TYR A 297
LEU A 308
ILE A 320
HIS A 238
THR A 200
 None
 1.33A 6djzB-4hz8A:
undetectable		 6djzB-4hz8A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l08 HYDROLASE,
ISOCHORISMATASE
FAMILY

(Pseudomonas
putida) 		no annotation 5 TYR B  72
LEU B  83
SER B 120
ILE B  70
THR B 153
 None
 1.27A 6djzB-4l08B:
undetectable		 6djzB-4l08B:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le7 PYOCIN L1

(Pseudomonas
aeruginosa) 		PF01453
(B_lectin) 		5 TRP A 251
SER A 250
ILE A 248
VAL A 235
LEU A  26
 None
EDO  A 305 (-3.9A)
None
None
None
 1.34A 6djzB-4le7A:
undetectable		 6djzB-4le7A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5c CARGO-TRANSPORT
PROTEIN YPP1

(Saccharomyces
cerevisiae) 		no annotation 5 TYR A 190
LEU A 193
SER A 432
ILE A  56
LEU A 187
 None
 1.39A 6djzB-4n5cA:
undetectable		 6djzB-4n5cA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nv4 SIGNAL PEPTIDASE I

(Bacillus
anthracis) 		PF00717
(Peptidase_S24) 		5 TYR A 109
LEU A 110
SER A 155
ILE A  84
PHE A 126
 None
 1.04A 6djzB-4nv4A:
undetectable		 6djzB-4nv4A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5w CALCIUM-BINDING
MITOCHONDRIAL
CARRIER PROTEIN
ARALAR2,CALCIUM-BIND
ING MITOCHONDRIAL
CARRIER PROTEIN
ARALAR2

(Homo sapiens) 		no annotation 5 ILE A 650
PHE A  99
THR A 119
VAL A 115
LEU A  45
 None
 1.26A 6djzB-4p5wA:
undetectable		 6djzB-4p5wA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q05 ESTERASE E25

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 LEU A 335
SER A 146
ILE A 136
THR A 130
LEU A 210
 None
 1.39A 6djzB-4q05A:
undetectable		 6djzB-4q05A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb7 UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF13149
(Mfa_like_1) 		5 TYR A 347
LEU A 307
ILE A 191
VAL A 148
THR A 338
 None
 1.23A 6djzB-4qb7A:
undetectable		 6djzB-4qb7A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlb PROBABLE GLYCOGEN
[STARCH] SYNTHASE

(Caenorhabditis
elegans) 		PF05693
(Glycogen_syn) 		5 LEU A 334
SER A 401
THR A 467
THR A 408
LEU A 411
 None
 1.40A 6djzB-4qlbA:
undetectable		 6djzB-4qlbA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2

(Danio rerio) 		PF00067
(p450) 		5 LEU A 250
ILE A 245
THR A 215
THR A 204
LEU A 202
 None
 1.21A 6djzB-4r20A:
undetectable		 6djzB-4r20A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra6 L-ASPARAGINASE

(Pyrococcus
furiosus) 		PF00710
(Asparaginase) 		5 LEU A 124
PHE A 163
HIS A  81
THR A  85
LEU A  25
 None
 1.39A 6djzB-4ra6A:
undetectable		 6djzB-4ra6A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rd8 UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 5 LEU A  73
ILE A 200
HIS A 199
THR A  39
VAL A  42
 None
 1.29A 6djzB-4rd8A:
undetectable		 6djzB-4rd8A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwr STAGE II SPORULATION
PROTEIN D

(Bacillus
anthracis) 		PF08486
(SpoIID) 		5 TRP A 277
PHE A 218
THR A 288
VAL A 286
THR A 260
 None
 1.21A 6djzB-4rwrA:
undetectable		 6djzB-4rwrA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpg DTDP-4-DEHYDRORHAMNO
SE REDUCTASE

(Streptococcus
pyogenes) 		PF04321
(RmlD_sub_bind) 		5 TYR A  55
LEU A  15
ILE A   2
THR A 199
LEU A 198
 MPD  A 301 (-4.6A)
None
None
MPD  A 301 ( 3.2A)
None
 1.26A 6djzB-4wpgA:
undetectable		 6djzB-4wpgA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yh2 GLUTATHIONE S
TRANSFERASE E6

(Drosophila
melanogaster) 		PF13417
(GST_N_3)
PF14497
(GST_C_3) 		5 LEU A 192
ILE A 152
VAL A 107
THR A 158
LEU A  85
 None
 1.26A 6djzB-4yh2A:
undetectable		 6djzB-4yh2A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yr1 ALKALINE PHOSPHATASE

(Escherichia
coli) 		PF00245
(Alk_phosphatase) 		5 LEU A  48
ILE A 307
VAL A 202
THR A 362
LEU A 363
 None
 1.22A 6djzB-4yr1A:
undetectable		 6djzB-4yr1A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyb HA1

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 LEU A  62
ILE A 228
HIS A 182
VAL A 200
LEU A  98
 None
 1.39A 6djzB-4yybA:
undetectable		 6djzB-4yybA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aoc ESTERASE

(Thermogutta
terrifontis) 		PF07859
(Abhydrolase_3) 		5 LEU A 240
SER A 126
PHE A 251
HIS A 248
THR A 223
 None
LEA  A1283 (-2.3A)
None
LEA  A1283 (-4.0A)
EDO  A1286 ( 4.9A)
 1.29A 6djzB-5aocA:
undetectable		 6djzB-5aocA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ar1 CELL DIVISION
CONTROL PROTEIN 11

(Saccharomyces
cerevisiae) 		PF00735
(Septin) 		5 TYR A 114
LEU A 287
PHE A 156
THR A  90
VAL A  28
 None
 1.38A 6djzB-5ar1A:
undetectable		 6djzB-5ar1A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1q U14 PROTEIN

(Human
betaherpesvirus
6B) 		PF04637
(Herpes_pp85) 		5 LEU A 122
ILE A 159
PHE A 166
THR A 194
THR A 240
 None
 1.13A 6djzB-5b1qA:
undetectable		 6djzB-5b1qA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2o CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Francisella
tularensis) 		no annotation 5 TYR A  24
LEU A  33
ILE A1183
HIS A1177
LEU A   6
 None
None
None
None
EDO  A1725 ( 4.5A)
 1.26A 6djzB-5b2oA:
1.2		 6djzB-5b2oA:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE

(Methanospirillum
hungatei) 		PF00485
(PRK) 		5 LEU A 130
ILE A 119
THR A 114
VAL A  17
LEU A  79
 None
 1.35A 6djzB-5b3fA:
undetectable		 6djzB-5b3fA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfw SINGLE CHAIN FV
FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		5 TYR H 602
LEU H 612
PHE H 152
HIS H 199
LEU H 598
 None
 1.10A 6djzB-5dfwH:
undetectable		 6djzB-5dfwH:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e44 FNR REGULATOR

(Aliivibrio
fischeri) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 LEU A 239
ILE A 231
PHE A 181
THR A 194
LEU A 214
 None
 1.06A 6djzB-5e44A:
3.8		 6djzB-5e44A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4o CAPSID PROTEIN VP1

(Norwalk virus) 		PF08435
(Calici_coat_C) 		5 ILE A 283
PHE A 327
VAL A 391
THR A 238
LEU A 237
 None
 1.10A 6djzB-5f4oA:
undetectable		 6djzB-5f4oA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO

(Homo sapiens) 		PF12933
(FTO_NTD)
PF12934
(FTO_CTD) 		5 TYR A 295
LEU A 289
PHE A  69
HIS A 321
VAL A  65
 AKG  A 603 (-4.6A)
None
None
None
None
 1.36A 6djzB-5f8pA:
4.4		 6djzB-5f8pA:
17.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hk2 SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1

(Homo sapiens) 		PF04622
(ERG2_Sigma1R) 		7 SER A 117
PHE A 133
HIS A 154
THR A 160
VAL A 162
TRP A 164
LEU A 186
 61V  A 301 (-2.9A)
None
61V  A 301 ( 4.1A)
None
None
None
None
 1.03A 6djzB-5hk2A:
35.1		 6djzB-5hk2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hk2 SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1

(Homo sapiens) 		PF04622
(ERG2_Sigma1R) 		12 TRP A  89
TYR A 103
LEU A 105
SER A 117
ILE A 124
PHE A 133
HIS A 154
THR A 160
VAL A 162
TRP A 164
THR A 181
LEU A 182
 None
61V  A 301 ( 4.3A)
None
61V  A 301 (-2.9A)
61V  A 301 ( 4.7A)
None
61V  A 301 ( 4.1A)
None
None
None
61V  A 301 ( 4.7A)
None
 0.63A 6djzB-5hk2A:
35.1		 6djzB-5hk2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i68 ALCOHOL OXIDASE 1

(Komagataella
pastoris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A 589
THR A 617
VAL A 613
THR A 628
LEU A 631
 None
FAD  A 702 (-3.4A)
None
None
None
 1.37A 6djzB-5i68A:
undetectable		 6djzB-5i68A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5il7 RAB FAMILY PROTEIN

(Chlorobaculum
tepidum) 		PF12799
(LRR_4)
PF13516
(LRR_6) 		5 LEU A  70
SER A  61
ILE A  56
VAL A   6
LEU A 106
 None
 1.39A 6djzB-5il7A:
undetectable		 6djzB-5il7A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf2 PREDICTED
ACETYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF00583
(Acetyltransf_1) 		5 TRP A 193
LEU A 250
PHE A 200
HIS A 120
THR A 289
 PO4  A 405 (-3.7A)
None
None
None
None
 1.40A 6djzB-5kf2A:
undetectable		 6djzB-5kf2A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA

(Methylobacillus
flagellatus) 		PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		5 TYR C  40
LEU C  43
ILE C 266
VAL C 273
THR C 242
 None
 1.21A 6djzB-5ks8C:
undetectable		 6djzB-5ks8C:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA

(Methylobacillus
flagellatus) 		PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		5 TYR C  40
LEU C  43
SER C 232
ILE C 266
THR C 242
 None
 1.30A 6djzB-5ks8C:
undetectable		 6djzB-5ks8C:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1

(Bos taurus) 		PF00146
(NADHdh) 		5 LEU H 285
ILE H 187
PHE H 270
THR H 238
THR H 145
 None
 1.23A 6djzB-5lc5H:
undetectable		 6djzB-5lc5H:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF06444
(NADH_dehy_S2_C) 		5 LEU N 248
ILE N 178
THR N 119
THR N 226
LEU N 230
 None
 1.34A 6djzB-5lc5N:
undetectable		 6djzB-5lc5N:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lk7 VP1

(Slow bee
paralysis virus) 		PF08762
(CRPV_capsid) 		5 TYR A 221
LEU A 105
SER A  96
ILE A  91
LEU A  72
 None
 0.96A 6djzB-5lk7A:
undetectable		 6djzB-5lk7A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1m INSULIN RECEPTOR
SUBSTRATE 1

(Homo sapiens) 		PF02174
(IRS) 		5 TRP A 164
LEU A 208
ILE A 223
VAL A 166
LEU A 254
 None
 1.31A 6djzB-5u1mA:
3.2		 6djzB-5u1mA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v3v GLOBIN

(Bacillus
anthracis) 		PF01152
(Bac_globin) 		5 LEU A  73
ILE A  82
PHE A  39
VAL A  29
LEU A 117
 HEM  A 201 (-4.2A)
HEM  A 201 (-4.1A)
HEM  A 201 (-4.0A)
None
None
 1.31A 6djzB-5v3vA:
undetectable		 6djzB-5v3vA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgx FLAVIN-DEPENDENT
HALOGENASE

(Malbranchea
aurantiaca) 		PF04820
(Trp_halogenase) 		5 TRP A  90
ILE A  47
THR A 418
THR A  83
LEU A 140
 None
FAD  A 701 (-4.9A)
None
None
None
 1.40A 6djzB-5wgxA:
undetectable		 6djzB-5wgxA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 5 LEU A1285
SER A1359
ILE A1111
PHE A1049
THR A1054
 None
 1.24A 6djzB-5wlhA:
undetectable		 6djzB-5wlhA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd0 GLUCANASE

(Paenibacillus
sp. X4) 		PF01270
(Glyco_hydro_8) 		5 TYR A 292
LEU A 264
THR A 381
VAL A 377
TRP A 373
 None
 1.07A 6djzB-5xd0A:
undetectable		 6djzB-5xd0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgj PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM

(Homo sapiens) 		no annotation 5 LEU A 445
ILE A 338
VAL A 376
THR A 358
LEU A 456
 None
 1.36A 6djzB-5xgjA:
undetectable		 6djzB-5xgjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES

(Staphylococcus
aureus) 		no annotation 5 LEU A 394
ILE A 351
THR A 465
VAL A 469
LEU A 525
 None
 1.18A 6djzB-5xt3A:
undetectable		 6djzB-5xt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 5 LEU A 241
HIS A 338
VAL A 272
THR A 258
LEU A 257
 None
None
DL1  A 601 ( 4.8A)
None
None
 1.27A 6djzB-6bfnA:
undetectable		 6djzB-6bfnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c93 CYTOCHROME P450 4B1

(Oryctolagus
cuniculus) 		no annotation 5 SER A 320
THR A 316
VAL A 179
TRP A 163
LEU A 478
 None
 1.34A 6djzB-6c93A:
undetectable		 6djzB-6c93A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		no annotation
no annotation 		5 TYR E  70
LEU H  61
ILE H   8
THR H  40
VAL H  43
 None
 1.26A 6djzB-6cfwE:
undetectable		 6djzB-6cfwE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f34 AMINO ACID
TRANSPORTER

(Geobacillus
kaustophilus) 		no annotation 5 SER A  64
PHE A 219
VAL A 222
THR A 265
LEU A 266
 None
 1.32A 6djzB-6f34A:
undetectable		 6djzB-6f34A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2v METHYLAMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		5 ASP A 197
GLN A 171
VAL A 196
GLU A 200
ALA A  86
 None
 1.42A 6djzB-1a2vA:
0.9		 6djzB-1a2vA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a80 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE A

(Corynebacterium
sp.) 		PF00248
(Aldo_ket_red) 		4 TYR A 105
GLN A 161
GLU A  53
ALA A  89
 None
NDP  A 300 (-3.3A)
None
None
 1.24A 6djzB-1a80A:
0.0		 6djzB-1a80A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ece ENDOCELLULASE E1

(Acidothermus
cellulolyticus) 		PF00150
(Cellulase) 		4 ASP A 344
GLN A  52
VAL A 339
ALA A  24
 None
 1.06A 6djzB-1eceA:
0.0		 6djzB-1eceA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0i PHOSPHOLIPASE D

(Streptomyces
sp. PMF) 		PF13091
(PLDc_2) 		4 GLN A 447
VAL A 375
GLU A 338
ALA A 484
 None
 1.14A 6djzB-1f0iA:
0.0		 6djzB-1f0iA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f9k ACIDIC LECTIN

(Psophocarpus
tetragonolobus) 		PF00139
(Lectin_legB) 		4 ASP A 125
GLN A 128
VAL A 135
GLU A 123
 CA  A 302 ( 2.2A)
None
None
MN  A 300 (-3.0A)
 1.02A 6djzB-1f9kA:
0.1		 6djzB-1f9kA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 TYR B 394
ASP B 401
VAL B 402
ALA B 704
 None
 1.20A 6djzB-1ffvB:
0.0		 6djzB-1ffvB:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggm GLYCINE--TRNA LIGASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 ASP A 293
GLN A 278
VAL A 292
GLU A 304
 None
None
None
GAP  A1550 ( 3.8A)
 1.20A 6djzB-1ggmA:
0.0		 6djzB-1ggmA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 TYR A  27
ASP A 544
GLN A   9
VAL A 547
 None
 1.26A 6djzB-1hcyA:
0.0		 6djzB-1hcyA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA

(Thermus
aquaticus) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		4 ASP A 201
GLN A 212
VAL A 204
ALA A 177
 None
 0.97A 6djzB-1hqmA:
undetectable		 6djzB-1hqmA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1d D-HYDANTOINASE

(Geobacillus
stearothermophilus) 		PF01979
(Amidohydro_1) 		4 ASP A 344
GLN A 266
GLU A 343
ALA A 412
 None
 1.19A 6djzB-1k1dA:
undetectable		 6djzB-1k1dA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhz METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		4 GLN D 150
VAL D 239
GLU D 209
ALA D 120
 None
None
FE  D 802 ( 3.2A)
None
 1.12A 6djzB-1mhzD:
undetectable		 6djzB-1mhzD:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qup SUPEROXIDE DISMUTASE
1 COPPER CHAPERONE

(Saccharomyces
cerevisiae) 		PF00080
(Sod_Cu)
PF00403
(HMA) 		4 TYR A 129
GLN A  88
VAL A 206
ALA A 126
 None
 1.20A 6djzB-1qupA:
undetectable		 6djzB-1qupA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sd5 PUTATIVE
ANTITERMINATOR

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg)
PF03861
(ANTAR) 		4 ASP A  65
GLN A  96
VAL A  66
GLU A  20
 None
 1.19A 6djzB-1sd5A:
undetectable		 6djzB-1sd5A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC

(Escherichia
coli) 		PF03009
(GDPD) 		4 TYR A 313
ASP A  65
GLU A 171
ALA A 237
 GOL  A1605 (-3.8A)
MG  A1601 ( 2.7A)
MG  A1601 ( 2.9A)
None
 0.99A 6djzB-1t8qA:
undetectable		 6djzB-1t8qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgd CHALCONE REDUCTASE

(Medicago sativa) 		PF00248
(Aldo_ket_red) 		4 TYR A 117
GLN A 188
GLU A  61
ALA A 101
 None
NAP  A 755 (-4.0A)
None
None
 1.26A 6djzB-1zgdA:
undetectable		 6djzB-1zgdA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsw GLYOXALASE FAMILY
PROTEIN

(Bacillus cereus) 		PF00903
(Glyoxalase) 		4 TYR A 111
GLN A 193
VAL A 183
GLU A 189
 None
 1.14A 6djzB-1zswA:
undetectable		 6djzB-1zswA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atm HYALURONOGLUCOSAMINI
DASE

(Vespula
vulgaris) 		PF01630
(Glyco_hydro_56) 		4 TYR A 184
ASP A 107
VAL A 105
GLU A 109
 None
MES  A 500 (-3.6A)
None
MES  A 500 (-3.6A)
 1.17A 6djzB-2atmA:
undetectable		 6djzB-2atmA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecf DIPEPTIDYL PEPTIDASE
IV

(Stenotrophomonas
maltophilia) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 TYR A 650
GLN A 305
GLU A 207
ALA A 528
 None
 1.19A 6djzB-2ecfA:
undetectable		 6djzB-2ecfA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 TYR A 114
GLN A 190
GLU A  58
ALA A  98
 None
NAP  A1001 (-4.0A)
None
None
 1.26A 6djzB-2fvlA:
undetectable		 6djzB-2fvlA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grv LPQW

(Mycolicibacterium
smegmatis) 		PF00496
(SBP_bac_5) 		4 ASP A 134
GLN A  48
VAL A 133
ALA A 326
 None
 1.24A 6djzB-2grvA:
undetectable		 6djzB-2grvA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is7 ALDOSE REDUCTASE

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 TYR A 107
GLN A 183
GLU A  51
ALA A  91
 None
NAP  A 316 (-3.7A)
None
None
 1.26A 6djzB-2is7A:
undetectable		 6djzB-2is7A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 4 TYR A 293
ASP A 276
VAL A 274
GLU A 254
 None
CA  A 620 (-2.1A)
None
CA  A 620 (-3.3A)
 1.23A 6djzB-2quaA:
undetectable		 6djzB-2quaA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN

(Bacillus
thuringiensis) 		PF01338
(Bac_thur_toxin) 		4 TYR A  48
ASP A 179
VAL A 125
GLU A 178
 TYR  A  48 ( 1.3A)
ASP  A 179 ( 0.6A)
VAL  A 125 ( 0.5A)
GLU  A 178 ( 0.5A)
 1.25A 6djzB-2rciA:
undetectable		 6djzB-2rciA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uw2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE M2
SUBUNIT

(Homo sapiens) 		PF00268
(Ribonuc_red_sm) 		4 ASP A 138
GLN A 165
VAL A 141
ALA A 104
 None
 1.22A 6djzB-2uw2A:
undetectable		 6djzB-2uw2A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vda TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 ASP A 293
VAL A 287
GLU A 294
ALA A 690
 None
 1.23A 6djzB-2vdaA:
undetectable		 6djzB-2vdaA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhf UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE CYLD

(Homo sapiens) 		PF00443
(UCH) 		4 TYR A 955
VAL A 616
GLU A 860
ALA A 884
 None
 1.16A 6djzB-2vhfA:
undetectable		 6djzB-2vhfA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00344
(SecY)
PF10559
(Plug_translocon) 		4 GLN A 149
VAL A  51
GLU A  81
ALA A 138
 None
 1.13A 6djzB-2ww9A:
undetectable		 6djzB-2ww9A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzm ALDO-KETO REDUCTASE

(Mycolicibacterium
smegmatis) 		PF00248
(Aldo_ket_red) 		4 TYR A 113
GLN A 169
GLU A  61
ALA A  97
 None
 1.26A 6djzB-2wzmA:
undetectable		 6djzB-2wzmA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8z LIPASE

(Pseudomonas sp.
MIS38) 		PF00353
(HemolysinCabind) 		4 TYR A 292
ASP A 275
VAL A 273
GLU A 253
 None
CA  A 618 (-2.2A)
None
CA  A 618 (-3.3A)
 1.11A 6djzB-2z8zA:
undetectable		 6djzB-2z8zA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqu AT4G19810

(Arabidopsis
thaliana) 		PF00704
(Glyco_hydro_18) 		4 TYR A 321
ASP A 329
VAL A 326
ALA A 341
 None
 1.02A 6djzB-3aquA:
undetectable		 6djzB-3aquA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axi OLIGO-1,6-GLUCOSIDAS
E IMA1

(Saccharomyces
cerevisiae) 		PF00128
(Alpha-amylase) 		4 TYR A 347
ASP A 307
VAL A 308
ALA A 277
 None
 1.24A 6djzB-3axiA:
undetectable		 6djzB-3axiA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		4 TYR A 113
GLN A 157
GLU A 181
ALA A 142
 ACT  A   1 ( 4.7A)
None
None
None
 1.11A 6djzB-3cghA:
undetectable		 6djzB-3cghA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebc TYPE-2 RESTRICTION
ENZYME HINCII

(Haemophilus
influenzae) 		PF09226
(Endonuc-HincII) 		4 TYR A   8
ASP A 172
VAL A 183
ALA A 188
 None
 1.25A 6djzB-3ebcA:
undetectable		 6djzB-3ebcA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk8 DISULPHIDE ISOMERASE

(Xylella
fastidiosa) 		PF13899
(Thioredoxin_7) 		4 ASP A  85
VAL A  86
GLU A  25
ALA A  18
 None
 1.19A 6djzB-3fk8A:
undetectable		 6djzB-3fk8A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		4 GLN A 323
VAL A 254
GLU A 281
ALA A 342
 None
 1.16A 6djzB-3g05A:
undetectable		 6djzB-3g05A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd5 ORNITHINE
CARBAMOYLTRANSFERASE

(Gloeobacter
violaceus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ASP A 144
VAL A 141
GLU A 296
ALA A 275
 None
 0.90A 6djzB-3gd5A:
undetectable		 6djzB-3gd5A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs0 COBRA VENOM FACTOR

(Naja kaouthia) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		4 TYR A 338
ASP A 512
VAL A 425
ALA A 410
 None
 1.25A 6djzB-3hs0A:
undetectable		 6djzB-3hs0A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijl MUCONATE
CYCLOISOMERASE

(Bacteroides
thetaiotaomicron) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A  94
ASP A 276
GLU A 277
ALA A  64
 DGL  A 385 (-4.5A)
MG  A 386 (-3.1A)
MG  A 386 ( 3.9A)
None
 1.19A 6djzB-3ijlA:
undetectable		 6djzB-3ijlA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg3 ISOCITRATE LYASE

(Yersinia pestis) 		PF00463
(ICL) 		4 TYR A 280
ASP A 247
GLN A 212
ALA A 236
 None
 1.23A 6djzB-3lg3A:
undetectable		 6djzB-3lg3A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ln3 DIHYDRODIOL
DEHYDROGENASE

(Mus musculus) 		PF00248
(Aldo_ket_red) 		4 TYR A 114
GLN A 190
GLU A  58
ALA A  98
 None
NAD  A 327 (-3.6A)
MLY  A 105 ( 4.3A)
None
 1.22A 6djzB-3ln3A:
undetectable		 6djzB-3ln3A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mos TRANSKETOLASE

(Homo sapiens) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 TYR A 147
ASP A 119
VAL A 120
ALA A 293
 None
 1.26A 6djzB-3mosA:
undetectable		 6djzB-3mosA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		4 ASP A 570
GLN A 541
GLU A 572
ALA A 373
 None
 1.21A 6djzB-3opyA:
undetectable		 6djzB-3opyA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owu STEROID
DELTA-ISOMERASE

(Pseudomonas
putida) 		PF12680
(SnoaL_2) 		4 TYR A  32
ASP A 103
GLN A 117
VAL A 104
 None
EQU  A 200 (-2.9A)
None
None
 1.26A 6djzB-3owuA:
undetectable		 6djzB-3owuA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 TYR B 360
ASP B 534
VAL B 447
ALA B 432
 None
 1.22A 6djzB-3prxB:
2.4		 6djzB-3prxB:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd8 PROBABLE
BACTERIOFERRITIN
BFRB

(Mycobacterium
tuberculosis) 		PF00210
(Ferritin) 		4 GLN A  98
VAL A 102
GLU A 131
ALA A 167
 None
 1.24A 6djzB-3qd8A:
undetectable		 6djzB-3qd8A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfb PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF13185
(GAF_2) 		4 TYR A  51
ASP A 128
VAL A  46
GLU A 110
 SME  A6888 (-4.9A)
SME  A6888 (-2.7A)
None
SME  A6888 (-2.1A)
 0.90A 6djzB-3rfbA:
undetectable		 6djzB-3rfbA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tpf ORNITHINE
CARBAMOYLTRANSFERASE

(Campylobacter
jejuni) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ASP A 131
VAL A 128
GLU A 284
ALA A 263
 None
 0.80A 6djzB-3tpfA:
undetectable		 6djzB-3tpfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqe MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE

(Coxiella
burnetii) 		PF00698
(Acyl_transf_1) 		4 TYR A  43
GLN A  59
GLU A 116
ALA A  37
 None
 1.25A 6djzB-3tqeA:
undetectable		 6djzB-3tqeA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Rattus
norvegicus) 		PF05028
(PARG_cat) 		4 ASP A 733
VAL A 818
GLU A 751
ALA A 870
 None
None
A1R  A1001 (-4.2A)
A1R  A1001 (-3.8A)
 1.23A 6djzB-3uelA:
undetectable		 6djzB-3uelA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uf6 LMO1369 PROTEIN

(Listeria
monocytogenes) 		PF01515
(PTA_PTB) 		4 GLN A 186
VAL A 175
GLU A 173
ALA A 223
 None
 1.13A 6djzB-3uf6A:
undetectable		 6djzB-3uf6A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2

(Homo sapiens) 		PF00268
(Ribonuc_red_sm) 		4 ASP A 138
GLN A 165
VAL A 141
ALA A 104
 None
FE  A 402 (-4.5A)
None
None
 1.12A 6djzB-3vpoA:
undetectable		 6djzB-3vpoA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbh ALKALINE PHOSPHATASE

(Halomonas sp.
#593) 		PF00245
(Alk_phosphatase) 		4 ASP A  64
GLN A  71
VAL A  63
GLU A  81
 None
 1.12A 6djzB-3wbhA:
undetectable		 6djzB-3wbhA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcz ALDO-KETO REDUCTASE
2E

(Bombyx mori) 		PF00248
(Aldo_ket_red) 		4 TYR A 117
GLN A 180
GLU A  61
ALA A 101
 None
NAP  A 401 (-3.3A)
None
None
 1.23A 6djzB-3wczA:
undetectable		 6djzB-3wczA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq8 BETA-GLUCOSIDASE

(Pyrococcus
furiosus) 		PF00232
(Glyco_hydro_1) 		4 TYR A 306
ASP A 269
VAL A 311
ALA A 393
 None
 0.99A 6djzB-3wq8A:
undetectable		 6djzB-3wq8A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		4 ASP A 257
VAL A 254
GLU A 268
ALA A 531
 MG  A1767 (-2.5A)
None
2PN  A1773 (-3.7A)
None
 1.12A 6djzB-4a01A:
undetectable		 6djzB-4a01A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aip FE-REGULATED PROTEIN
B

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 TYR A 445
ASP A 369
VAL A 323
ALA A 158
 None
 1.00A 6djzB-4aipA:
undetectable		 6djzB-4aipA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE

(Trypanosoma
brucei) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ASP A 336
GLN A 394
GLU A 342
ALA A 367
 None
 1.22A 6djzB-4bi9A:
undetectable		 6djzB-4bi9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cog KYNURENINE
FORMAMIDASE

(Burkholderia
cenocepacia) 		PF04199
(Cyclase) 		4 TYR A  59
VAL A 126
GLU A 172
ALA A  55
 None
None
ZN  A 401 (-2.0A)
None
 1.05A 6djzB-4cogA:
undetectable		 6djzB-4cogA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffl PYLC

(Methanosarcina
barkeri) 		PF02655
(ATP-grasp_3) 		4 ASP A 241
GLN A  12
GLU A 239
ALA A 141
 MG  A 905 ( 2.7A)
LYS  A 901 (-3.9A)
MG  A 905 ( 1.7A)
ADP  A 902 ( 4.2A)
 1.22A 6djzB-4fflA:
undetectable		 6djzB-4fflA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn5 ELONGATION FACTOR G
1

(Pseudomonas
aeruginosa) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 TYR A 285
ASP A 184
GLN A  78
ALA A 226
 None
 1.10A 6djzB-4fn5A:
undetectable		 6djzB-4fn5A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzi PROSTAGLANDIN F
SYNTHASE

(Trypanosoma
cruzi) 		PF00248
(Aldo_ket_red) 		4 TYR A 108
GLN A 162
GLU A  56
ALA A  92
 None
 1.23A 6djzB-4fziA:
undetectable		 6djzB-4fziA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)

(Schistosoma
japonicum) 		PF00248
(Aldo_ket_red) 		4 TYR A 107
GLN A 181
GLU A  51
ALA A  91
 None
 1.23A 6djzB-4hbkA:
undetectable		 6djzB-4hbkA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzp BIFUNCTIONAL
METHYLMALONYL-COA:AC
P
ACYLTRANSFERASE/DECA
RBOXYLASE

(Streptomyces
atroolivaceus) 		no annotation 4 ASP A 255
GLN A 309
VAL A 254
ALA A 190
 None
 1.22A 6djzB-4hzpA:
undetectable		 6djzB-4hzpA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjj CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Thermobifida
fusca) 		PF02011
(Glyco_hydro_48) 		4 ASP A 498
GLN A 623
VAL A 499
ALA A  41
 CBI  A 701 ( 3.1A)
None
None
CBI  A 701 ( 3.9A)
 1.15A 6djzB-4jjjA:
undetectable		 6djzB-4jjjA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3f PROBABLE
TONB-DEPENDENT
RECEPTOR

(Pseudomonas
aeruginosa) 		PF03180
(Lipoprotein_9) 		4 TYR A  82
GLN A  62
VAL A  65
ALA A 130
 None
 1.24A 6djzB-4k3fA:
undetectable		 6djzB-4k3fA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k49 ESTERASE YDII

(Escherichia
coli) 		no annotation 4 GLN C 112
VAL C  80
GLU C  63
ALA C  87
 None
 1.26A 6djzB-4k49C:
undetectable		 6djzB-4k49C:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzv EPITHELIAL CELL
ADHESION MOLECULE

(Homo sapiens) 		PF00086
(Thyroglobulin_1) 		4 ASP A 211
GLN A 175
VAL A 207
ALA A  71
 None
 1.17A 6djzB-4mzvA:
undetectable		 6djzB-4mzvA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz0 GENOME POLYPROTEIN

(Cardiovirus A) 		PF00680
(RdRP_1) 		4 TYR A 285
ASP A 177
GLN A 155
VAL A 178
 None
 1.18A 6djzB-4nz0A:
undetectable		 6djzB-4nz0A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 GLN A 902
VAL A 947
GLU A 949
ALA A 867
 None
 1.20A 6djzB-4o9xA:
undetectable		 6djzB-4o9xA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4op4 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Vibrio cholerae) 		PF01546
(Peptidase_M20) 		4 ASP A  70
GLN A  27
GLU A 136
ALA A 100
 None
None
ZN  A 302 (-1.7A)
None
 1.16A 6djzB-4op4A:
undetectable		 6djzB-4op4A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4sbv SOUTHERN BEAN MOSAIC
VIRUS COAT PROTEIN

(Southern bean
mosaic virus) 		PF00729
(Viral_coat) 		4 GLN A 136
VAL A 225
GLU A  89
ALA A 202
 None
 1.15A 6djzB-4sbvA:
undetectable		 6djzB-4sbvA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y90 TRIOSEPHOSPHATE
ISOMERASE

(Deinococcus
radiodurans) 		PF00121
(TIM) 		4 TYR A 163
GLN A 143
GLU A 182
ALA A 175
 None
None
GOL  A 303 (-2.4A)
None
 1.17A 6djzB-4y90A:
undetectable		 6djzB-4y90A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zq8 ISOPRENOID SYNTHASE

(Streptomyces
lydicus) 		no annotation 4 ASP A 108
VAL A 107
GLU A 113
ALA A 199
 None
 1.12A 6djzB-4zq8A:
undetectable		 6djzB-4zq8A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		4 ASP A 427
GLN A 412
VAL A 426
ALA A 838
 None
 0.95A 6djzB-5dkxA:
undetectable		 6djzB-5dkxA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fpr DNA LIGASE

(Staphylococcus
aureus) 		PF01653
(DNA_ligase_aden) 		4 GLN A 129
VAL A  73
GLU A 140
ALA A 198
 None
 1.06A 6djzB-5fprA:
undetectable		 6djzB-5fprA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT THETA
T-COMPLEX PROTEIN 1
SUBUNIT ZETA

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1)
PF00118
(Cpn60_TCP1) 		4 TYR z 386
ASP z 163
VAL z 162
ALA q  88
 None
 0.91A 6djzB-5gw5z:
undetectable		 6djzB-5gw5z:
19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hk2 SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1

(Homo sapiens) 		PF04622
(ERG2_Sigma1R) 		4 ASP A 126
VAL A 152
GLU A 172
ALA A  86
 61V  A 301 (-3.2A)
None
61V  A 301 (-2.9A)
None
 1.20A 6djzB-5hk2A:
35.1		 6djzB-5hk2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hk2 SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1

(Homo sapiens) 		PF04622
(ERG2_Sigma1R) 		6 TYR A 120
ASP A 126
GLN A 135
VAL A 152
GLU A 172
ALA A 185
 None
61V  A 301 (-3.2A)
None
None
61V  A 301 (-2.9A)
61V  A 301 ( 4.2A)
 0.36A 6djzB-5hk2A:
35.1		 6djzB-5hk2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic8 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 4 GLN A 341
VAL A 321
GLU A 298
ALA A 383
 None
 1.01A 6djzB-5ic8A:
undetectable		 6djzB-5ic8A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jho ELECTRONEUTRAL
SODIUM BICARBONATE
EXCHANGER 1

(Homo sapiens) 		PF07565
(Band_3_cyto) 		4 ASP A 328
GLN A  47
VAL A 319
GLU A 325
 None
 1.06A 6djzB-5jhoA:
undetectable		 6djzB-5jhoA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdr ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
ALPHA

(Staphylococcus
aureus) 		PF03255
(ACCA) 		4 ASP A  91
GLN A 111
GLU A 131
ALA A 164
 None
None
None
SO4  A 402 (-3.6A)
 1.20A 6djzB-5kdrA:
undetectable		 6djzB-5kdrA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 TYR X 108
GLN X 184
GLU X  52
ALA X  92
 None
NAP  X 401 (-3.8A)
None
None
 1.20A 6djzB-5liyX:
undetectable		 6djzB-5liyX:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1s DNA POLYMERASE III
SUBUNIT THETA

(Escherichia
coli) 		PF06440
(DNA_pol3_theta) 		4 ASP F  19
GLN F  44
VAL F  18
ALA F  62
 None
 1.02A 6djzB-5m1sF:
undetectable		 6djzB-5m1sF:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m28 MALE1

(Lactobacillus
casei) 		PF13416
(SBP_bac_8) 		4 TYR A 164
GLN A  81
VAL A  77
ALA A 266
 MLR  A 401 (-2.8A)
MLR  A 401 (-3.9A)
None
None
 1.23A 6djzB-5m28A:
undetectable		 6djzB-5m28A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1q METHYL-COENZYME M
REDUCTASE III FROM
METHANOTHERMOCOCCUS
THERMOLITHOTROPHICUS
SUBUNIT BETA

(Methanothermococcus
thermolithotrophicus) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ASP B 278
VAL B 280
GLU B 277
ALA B 258
 None
 1.24A 6djzB-5n1qB:
undetectable		 6djzB-5n1qB:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nit GLUCOSE OXIDASE

(Aspergillus
niger) 		no annotation 4 TYR A 515
ASP A 424
GLN A 464
VAL A 425
 FAD  A 601 (-4.3A)
None
None
None
 1.01A 6djzB-5nitA:
undetectable		 6djzB-5nitA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0x PUTATIVE FERRIC
REDUCTASE

(Cylindrospermum
stagnale) 		PF08022
(FAD_binding_8)
PF08030
(NAD_binding_6) 		4 TYR A 684
ASP A 646
GLN A 676
GLU A 649
 GOL  A 826 ( 4.6A)
None
None
None
 1.18A 6djzB-5o0xA:
undetectable		 6djzB-5o0xA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1m RUBBER OXYGENASE

(Streptomyces
sp. K30) 		PF09995
(DUF2236) 		4 ASP A 272
GLN A 262
VAL A  42
ALA A 104
 None
 1.18A 6djzB-5o1mA:
undetectable		 6djzB-5o1mA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6f LPXTG-MOTIF CELL
WALL ANCHOR DOMAIN
PROTEIN

(Mobiluncus
mulieris) 		no annotation 4 ASP A 245
GLN A 235
VAL A 238
ALA A 265
 None
 1.11A 6djzB-5u6fA:
undetectable		 6djzB-5u6fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7w APYRASE

(Trifolium
repens) 		PF01150
(GDA1_CD39) 		4 ASP A  37
GLN A 388
GLU A  39
ALA A 395
 None
 0.97A 6djzB-5u7wA:
undetectable		 6djzB-5u7wA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uoh CARBOXYLESTERASE A

(Mycobacterium
tuberculosis) 		PF00561
(Abhydrolase_1) 		4 ASP A 259
GLN A 396
GLU A 262
ALA A 412
 None
 1.25A 6djzB-5uohA:
undetectable		 6djzB-5uohA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE

(Naegleria
fowleri) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 TYR A 472
VAL A 434
GLU A 432
ALA A 467
 None
None
None
EDO  A 505 ( 4.6A)
 1.24A 6djzB-5v96A:
undetectable		 6djzB-5v96A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf3 MAJOR CAPSID PROTEIN

(Escherichia
virus T4) 		PF07068
(Gp23) 		4 TYR A 433
GLN A 427
VAL A 412
ALA A 314
 None
 1.25A 6djzB-5vf3A:
undetectable		 6djzB-5vf3A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w6m HISTIDINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		no annotation 4 ASP A 488
VAL A 489
GLU A 470
ALA A 416
 None
 1.23A 6djzB-5w6mA:
undetectable		 6djzB-5w6mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x33 LTB4
RECEPTOR,LYSOZYME,LT
B4 RECEPTOR

(Cavia
porcellus;
Escherichia
virus T4) 		no annotation 4 TYR A 174
ASP A 243
VAL A 242
GLU A 187
 None
 1.06A 6djzB-5x33A:
undetectable		 6djzB-5x33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		4 ASP C2964
GLN C3291
GLU C2960
ALA C3255
 None
 1.18A 6djzB-5y3rC:
undetectable		 6djzB-5y3rC:
4.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aqh LYSINE--TRNA LIGASE

(Mycolicibacterium
thermoresistibile) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 ASP A 412
VAL A 387
GLU A 419
ALA A 213
 None
None
KRS  A 602 (-3.8A)
LYS  A 601 (-3.4A)
 1.18A 6djzB-6aqhA:
undetectable		 6djzB-6aqhA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cia ALDO/KETO REDUCTASE

(Klebsiella
pneumoniae) 		no annotation 4 TYR A 110
GLN A 165
GLU A  61
ALA A  94
 None
NDP  A 301 (-4.2A)
None
None
 1.20A 6djzB-6ciaA:
undetectable		 6djzB-6ciaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es9 ACYL-COA
DEHYDROGENASE

(Paracoccus
denitrificans) 		no annotation 4 TYR A 472
GLN A 427
GLU A 172
ALA A 230
 None
 1.07A 6djzB-6es9A:
undetectable		 6djzB-6es9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3

(Homo sapiens) 		no annotation 4 TYR A 114
GLN A 190
GLU A  58
ALA A  98
 None
NAP  A 401 (-3.8A)
None
None
 1.24A 6djzB-6f2uA:
undetectable		 6djzB-6f2uA:
undetectable