SIMILAR PATTERNS OF AMINO ACIDS FOR 6DJZ_A_GMJA301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1y PROTEIN
(BETA-AMYLASE)

(Hordeum vulgare) 		PF01373
(Glyco_hydro_14) 		4 ASP A 174
GLN A  11
GLU A 176
THR A 340
 None
None
None
BGC  A 551 (-3.1A)
 1.27A 6djzA-1b1yA:
0.0		 6djzA-1b1yA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvr GINGIPAIN R

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		4 SER A 252
ASP A  78
GLU A 258
THR A 224
 None
CA  A 503 (-2.1A)
CA  A 503 (-2.3A)
None
 1.47A 6djzA-1cvrA:
undetectable		 6djzA-1cvrA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5y ROB TRANSCRIPTION
FACTOR

(Escherichia
coli) 		PF06445
(GyrI-like)
PF12833
(HTH_18) 		4 SER A  62
ASP A  19
GLU A 150
THR A  69
 None
 1.14A 6djzA-1d5yA:
0.0		 6djzA-1d5yA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggm GLYCINE--TRNA LIGASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 SER A 284
ASP A 293
GLN A 278
GLU A 304
 None
None
None
GAP  A1550 ( 3.8A)
 1.00A 6djzA-1ggmA:
0.0		 6djzA-1ggmA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmu PROTEIN MU-1

(Reovirus sp.) 		PF05993
(Reovirus_M2) 		4 SER B 406
TYR B 467
GLN B 418
GLU B 411
 None
 1.27A 6djzA-1jmuB:
2.6		 6djzA-1jmuB:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ks8 ENDO-B-1,4-GLUCANASE

(Nasutitermes
takasagoensis) 		PF00759
(Glyco_hydro_9) 		4 ASP A 213
GLN A 261
GLU A 214
THR A  70
 None
 1.35A 6djzA-1ks8A:
0.0		 6djzA-1ks8A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ln0 INTRON-ASSOCIATED
ENDONUCLEASE 1

(Escherichia
virus T4) 		PF01541
(GIY-YIG) 		4 SER A  42
TYR A  17
ASP A  34
GLN A  46
 None
 1.21A 6djzA-1ln0A:
0.0		 6djzA-1ln0A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n3p LECTIN PAL

(Pterocarpus
angolensis) 		PF00139
(Lectin_legB) 		4 ASP A 150
GLN A 117
GLU A 128
THR A 131
 None
None
MN  A 271 (-2.8A)
None
 1.50A 6djzA-1n3pA:
0.0		 6djzA-1n3pA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oz9 HYPOTHETICAL PROTEIN
AQ_1354

(Aquifex
aeolicus) 		PF02130
(UPF0054) 		4 SER A  71
ASP A 124
GLU A 126
THR A  67
 None
 1.38A 6djzA-1oz9A:
0.0		 6djzA-1oz9A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))

(Sulfolobus
solfataricus) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 SER A 335
TYR A  88
GLN A 178
GLU A 350
 None
 1.45A 6djzA-1qdlA:
undetectable		 6djzA-1qdlA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wnb PUTATIVE BETAINE
ALDEHYDE
DEHYDROGENASE

(Escherichia
coli) 		PF00171
(Aldedh) 		4 TYR A 287
ASP A 401
GLN A 426
THR A 387
 None
 1.36A 6djzA-1wnbA:
undetectable		 6djzA-1wnbA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x03 SH3-CONTAINING
GRB2-LIKE PROTEIN 2

(Homo sapiens) 		PF03114
(BAR) 		4 SER A  44
ASP A 148
GLN A 155
THR A  52
 None
 1.32A 6djzA-1x03A:
undetectable		 6djzA-1x03A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfu CALMODULIN-SENSITIVE
ADENYLATE CYCLASE

(Bacillus
anthracis) 		PF03497
(Anthrax_toxA)
PF07737
(ATLF) 		4 TYR A 442
GLN A 368
GLU A 467
THR A 457
 None
 1.47A 6djzA-1xfuA:
undetectable		 6djzA-1xfuA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xx4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL

(Rattus
norvegicus) 		PF00378
(ECH_1) 		4 SER A 243
ASP A 149
GLN A 239
THR A 249
 None
 1.33A 6djzA-1xx4A:
undetectable		 6djzA-1xx4A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yuz NIGERYTHRIN

(Desulfovibrio
vulgaris) 		PF02915
(Rubrerythrin) 		4 SER A 110
TYR A  47
GLU A 118
THR A  69
 None
None
FE  A 301 (-2.5A)
None
 1.46A 6djzA-1yuzA:
undetectable		 6djzA-1yuzA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsw GLYOXALASE FAMILY
PROTEIN

(Bacillus cereus) 		PF00903
(Glyoxalase) 		4 SER A 159
TYR A 111
GLN A 193
GLU A 189
 None
 0.92A 6djzA-1zswA:
undetectable		 6djzA-1zswA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aex COPROPORPHYRINOGEN
III OXIDASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01218
(Coprogen_oxidas) 		4 SER A 420
TYR A 392
ASP A 400
THR A 284
 None
 1.23A 6djzA-2aexA:
undetectable		 6djzA-2aexA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5l NONSTRUCTURAL
PROTEIN V

(Mammalian
rubulavirus 5) 		PF13008
(zf-Paramyx-P)
PF14313
(Soyouz_module) 		4 SER C  37
GLN C  30
GLU C  25
THR C  19
 None
 1.48A 6djzA-2b5lC:
undetectable		 6djzA-2b5lC:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c08 SH3-CONTAINING
GRB2-LIKE PROTEIN 2

(Rattus
norvegicus) 		PF03114
(BAR) 		4 SER A  44
ASP A 148
GLN A 155
THR A  52
 None
 1.37A 6djzA-2c08A:
undetectable		 6djzA-2c08A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6r TRIOSEPHOSPHATE
ISOMERASE

(Methanocaldococcus
jannaschii) 		PF00121
(TIM) 		4 SER A 200
TYR A  10
GLU A  92
THR A   9
 None
 1.32A 6djzA-2h6rA:
undetectable		 6djzA-2h6rA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 SER A 266
TYR A 286
GLU A 255
THR A 290
 None
 1.40A 6djzA-2hckA:
undetectable		 6djzA-2hckA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ido DNA POLYMERASE III
EPSILON SUBUNIT

(Escherichia
coli) 		PF00929
(RNase_T) 		4 SER A 130
TYR A 175
GLU A  94
THR A 179
 None
 1.19A 6djzA-2idoA:
undetectable		 6djzA-2idoA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7v TLL2115 PROTEIN

(Synechococcus
elongatus) 		PF13354
(Beta-lactamase2) 		4 SER A 264
GLN A 269
GLU A 258
THR A 204
 None
 1.49A 6djzA-2j7vA:
undetectable		 6djzA-2j7vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l3y INTERLEUKIN-6

(Mus musculus) 		PF00489
(IL6) 		4 SER A 175
ASP A  60
GLN A 170
GLU A  64
 None
 1.29A 6djzA-2l3yA:
undetectable		 6djzA-2l3yA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n0s FE-HYDROGENASE

(Chlamydomonas
reinhardtii) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C) 		4 SER A 164
TYR A 428
ASP A 200
GLN A 207
 None
 1.45A 6djzA-2n0sA:
undetectable		 6djzA-2n0sA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n0s FE-HYDROGENASE

(Chlamydomonas
reinhardtii) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C) 		4 SER A 164
TYR A 428
GLN A 207
GLU A 439
 None
 1.25A 6djzA-2n0sA:
undetectable		 6djzA-2n0sA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nd4 AMYLASE-BINDING
PROTEIN ABPA

(Streptococcus
parasanguinis) 		no annotation 4 TYR A 122
GLN A 118
GLU A  37
THR A 132
 None
 1.29A 6djzA-2nd4A:
undetectable		 6djzA-2nd4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qks KIR3.1-PROKARYOTIC
KIR CHANNEL CHIMERA

(Mus musculus;
Paraburkholderia
xenovorans) 		PF01007
(IRK) 		4 ASP A 266
GLN A 239
GLU A 267
THR A 261
 None
 1.38A 6djzA-2qksA:
undetectable		 6djzA-2qksA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqo NEUROPILIN-2

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		4 SER A 470
ASP A 371
GLN A 504
GLU A 370
 None
 1.49A 6djzA-2qqoA:
2.3		 6djzA-2qqoA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vlc TYPE 2
RIBOSOME-INACTIVATIN
G PROTEIN CINNAMOMIN
III

(Cinnamomum
camphora) 		PF00161
(RIP)
PF00652
(Ricin_B_lectin) 		4 SER A 218
ASP A 291
GLN A 210
THR A 335
 None
 1.26A 6djzA-2vlcA:
undetectable		 6djzA-2vlcA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw THIOSULFATE
REDUCTASE

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 TYR A  90
GLN A  35
GLU A 762
THR A  89
 None
 1.50A 6djzA-2vpwA:
undetectable		 6djzA-2vpwA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 SER A 333
GLN A 347
GLU A 389
THR A 496
 3ES  A1611 (-4.4A)
None
ZN  A1620 ( 2.4A)
3ES  A1611 (-3.4A)
 1.41A 6djzA-2xydA:
0.8		 6djzA-2xydA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]

(Corynebacterium
glutamicum) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		4 SER A 120
TYR A 217
GLN A  32
THR A 202
 None
 1.38A 6djzA-2zciA:
undetectable		 6djzA-2zciA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bew MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
GLYCOPROTEIN
HAPLOTYPE B21

(Gallus gallus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 SER A  97
TYR A 156
GLN A 112
THR A 160
 None
 1.49A 6djzA-3bewA:
undetectable		 6djzA-3bewA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfx UPF0100 PROTEIN
MA_0280

(Methanosarcina
acetivorans) 		PF13531
(SBP_bac_11) 		4 SER A  97
TYR A 294
ASP A 161
GLU A 227
 None
None
WO4  A 701 (-2.8A)
WO4  A 701 (-2.5A)
 1.28A 6djzA-3cfxA:
undetectable		 6djzA-3cfxA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfz UPF0100 PROTEIN
MJ1186

(Methanocaldococcus
jannaschii) 		PF13531
(SBP_bac_11) 		4 SER A  94
TYR A 289
ASP A 158
GLU A 221
 None
None
WO4  A 701 (-2.7A)
WO4  A 701 (-2.6A)
 1.30A 6djzA-3cfzA:
undetectable		 6djzA-3cfzA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb7 INSECTICIDAL
DELTA-ENDOTOXIN
CRY8EA1

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 TYR A 293
ASP A 644
GLN A 300
THR A 292
 None
 1.38A 6djzA-3eb7A:
undetectable		 6djzA-3eb7A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 1

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 SER B 278
ASP B 392
GLN B 386
THR B 150
 None
 1.38A 6djzA-3hhsB:
undetectable		 6djzA-3hhsB:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE

(Idiomarina
loihiensis) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		4 TYR A 297
ASP A 294
GLN A 291
THR A 316
 None
EDO  A 385 (-3.7A)
EDO  A 391 ( 3.9A)
None
 1.46A 6djzA-3llxA:
undetectable		 6djzA-3llxA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my9 MUCONATE
CYCLOISOMERASE

(Azorhizobium
caulinodans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 SER A 138
TYR A 296
ASP A 196
GLU A 222
 None
None
MG  A 378 ( 4.2A)
MG  A 378 (-3.1A)
 1.33A 6djzA-3my9A:
undetectable		 6djzA-3my9A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC

(Zea mays) 		PF03055
(RPE65) 		4 SER A 333
TYR A 325
ASP A 329
GLN A 290
 None
 1.23A 6djzA-3npeA:
undetectable		 6djzA-3npeA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qz3 FERRITIN

(Vibrio cholerae) 		PF00210
(Ferritin) 		4 TYR A  30
GLN A  58
GLU A 136
THR A  96
 None
None
EDO  A 182 ( 4.9A)
None
 1.30A 6djzA-3qz3A:
undetectable		 6djzA-3qz3A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t24 PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 TYR A 376
GLN A 173
GLU A 302
THR A 374
 None
 1.34A 6djzA-3t24A:
undetectable		 6djzA-3t24A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfz CYCLASE

(Streptomyces
sp. R1128) 		PF10604
(Polyketide_cyc2) 		4 SER A  64
GLN A  47
GLU A  38
THR A  61
 CXS  A 171 (-2.9A)
None
None
None
 1.28A 6djzA-3tfzA:
undetectable		 6djzA-3tfzA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u8e PAPAIN-LIKE CYSTEINE
PROTEASE

(Crocus sativus) 		PF00112
(Peptidase_C1) 		4 SER A 136
TYR A 133
GLN A 140
THR A 159
 None
 1.37A 6djzA-3u8eA:
undetectable		 6djzA-3u8eA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upn PENICILLIN-BINDING
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00905
(Transpeptidase) 		4 TYR A 366
GLN A 386
GLU A 166
THR A 137
 None
 1.35A 6djzA-3upnA:
undetectable		 6djzA-3upnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usz EXO-1,3/1,4-BETA-GLU
CANASE

(Pseudoalteromonas
sp. BB1) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		4 SER A  61
GLN A  40
GLU A 155
THR A 108
 None
 1.50A 6djzA-3uszA:
undetectable		 6djzA-3uszA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi1 ALKALINE
METALLOPROTEINASE

(Pseudomonas
aeruginosa) 		PF08548
(Peptidase_M10_C)
PF13583
(Reprolysin_4) 		4 SER A  45
TYR A 246
GLN A  43
THR A 107
 None
 1.50A 6djzA-3vi1A:
undetectable		 6djzA-3vi1A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 SER A1824
TYR A1912
GLN A1826
GLU A1881
 None
 1.38A 6djzA-3vkgA:
undetectable		 6djzA-3vkgA:
5.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE

(Ascaris suum) 		PF13085
(Fer2_3)
PF13534
(Fer4_17) 		4 SER B 169
TYR B 167
GLN B 173
THR B 278
 None
 1.45A 6djzA-3vrbB:
undetectable		 6djzA-3vrbB:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ads PDX2 PROTEIN

(Plasmodium
falciparum) 		PF01174
(SNO) 		4 ASP G  14
GLN G  12
GLU G 198
THR G 193
 None
 1.37A 6djzA-4adsG:
undetectable		 6djzA-4adsG:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amf PHOX

(Pseudomonas
fluorescens) 		PF05787
(DUF839) 		4 SER A 477
ASP A 292
GLU A 273
THR A 534
 None
FEO  A1595 ( 3.1A)
FEO  A1595 ( 2.4A)
None
 1.31A 6djzA-4amfA:
undetectable		 6djzA-4amfA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cij GST REP

(Geobacillus
stearothermophilus) 		PF02486
(Rep_trans) 		4 ASP A   9
GLN A  84
GLU A 196
THR A 164
 None
 1.40A 6djzA-4cijA:
undetectable		 6djzA-4cijA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum) 		PF00703
(Glyco_hydro_2) 		4 SER A 423
ASP A 451
GLN A 195
GLU A 489
 None
 1.44A 6djzA-4cvuA:
undetectable		 6djzA-4cvuA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d72 GLYCOSIDE HYDROLASE

(Streptococcus
pneumoniae) 		PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C) 		4 ASP A 657
GLN A 590
GLU A 710
THR A 520
 None
None
FUC  A2007 ( 2.9A)
None
 0.96A 6djzA-4d72A:
undetectable		 6djzA-4d72A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dal PUTATIVE ALDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 TYR A 287
ASP A 401
GLN A 426
THR A 387
 None
 1.35A 6djzA-4dalA:
undetectable		 6djzA-4dalA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f06 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		4 SER A 140
ASP A 385
GLN A 358
THR A 102
 None
None
None
PHB  A 401 ( 3.7A)
 1.47A 6djzA-4f06A:
undetectable		 6djzA-4f06A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffl PYLC

(Methanosarcina
barkeri) 		PF02655
(ATP-grasp_3) 		4 SER A 136
ASP A 225
GLN A  12
GLU A 227
 LYS  A 901 ( 3.8A)
MG  A 906 ( 3.9A)
LYS  A 901 (-3.9A)
MG  A 906 (-2.7A)
 1.47A 6djzA-4fflA:
undetectable		 6djzA-4fflA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffl PYLC

(Methanosarcina
barkeri) 		PF02655
(ATP-grasp_3) 		4 SER A 137
ASP A 241
GLN A  12
GLU A 239
 LYS  A 901 (-3.1A)
MG  A 905 ( 2.7A)
LYS  A 901 (-3.9A)
MG  A 905 ( 1.7A)
 1.49A 6djzA-4fflA:
undetectable		 6djzA-4fflA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 SER A 452
TYR A 130
ASP A 434
GLN A 483
 None
 1.39A 6djzA-4flnA:
undetectable		 6djzA-4flnA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqt HEAT SHOCK PROTEIN
90

(Caenorhabditis
elegans) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 ASP A 165
GLN A 149
GLU A 167
THR A  69
 None
 1.08A 6djzA-4gqtA:
undetectable		 6djzA-4gqtA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 SER A 218
GLN A 196
GLU A 628
THR A 224
 None
 1.45A 6djzA-4iigA:
undetectable		 6djzA-4iigA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4it1 PUTATIVE GLUCARATE
DEHYDRATASE

(Pseudomonas
fluorescens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 SER A 108
GLN A  81
GLU A 115
THR A 303
 None
 1.33A 6djzA-4it1A:
undetectable		 6djzA-4it1A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH

(Lechevalieria
aerocolonigenes) 		PF04820
(Trp_halogenase) 		4 SER A 166
GLN A 452
GLU A  67
THR A  51
 None
 1.18A 6djzA-4lu6A:
undetectable		 6djzA-4lu6A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7c TRNA
(MO5U34)-METHYLTRANS
FERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF08003
(Methyltransf_9) 		4 SER A 104
TYR A 132
GLN A 279
GLU A 221
 None
None
ACT  A 402 (-3.1A)
None
 1.20A 6djzA-4p7cA:
undetectable		 6djzA-4p7cA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0w DNA REPAIR PROTEIN
RAD2

(Saccharomyces
cerevisiae) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 SER A 863
TYR A 865
ASP A 813
GLU A 794
 None
None
CA  A1001 (-3.4A)
CA  A1001 (-2.9A)
 1.45A 6djzA-4q0wA:
undetectable		 6djzA-4q0wA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi6 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		4 TYR A  90
ASP A 210
GLN A 170
THR A  88
 None
 1.30A 6djzA-4qi6A:
undetectable		 6djzA-4qi6A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnl TAIL FIBER PROTEIN

(Escherichia
virus G7C) 		no annotation 4 SER A 349
TYR A 391
ASP A 275
THR A 428
 None
None
CL  A 911 ( 4.5A)
None
 1.39A 6djzA-4qnlA:
undetectable		 6djzA-4qnlA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s13 FERULIC ACID
DECARBOXYLASE 1

(Saccharomyces
cerevisiae) 		PF01977
(UbiD) 		4 TYR A 476
ASP A 407
GLN A 373
THR A 478
 None
 1.28A 6djzA-4s13A:
undetectable		 6djzA-4s13A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk4 INTEGRIN ALPHA-5

(Homo sapiens) 		PF01839
(FG-GAP) 		4 SER A  77
TYR A 119
GLN A  46
GLU A 147
 None
 1.33A 6djzA-4wk4A:
undetectable		 6djzA-4wk4A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio cholerae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 SER A 137
GLN A 112
GLU A 189
THR A 163
 None
 1.41A 6djzA-4xoxA:
undetectable		 6djzA-4xoxA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5auk FERREDOXIN-1

(Synechocystis
sp. PCC 6803) 		PF00111
(Fer2) 		4 SER A  45
ASP A  94
GLN A  68
GLU A  93
 None
None
None
BEN  A 109 (-4.5A)
 1.34A 6djzA-5aukA:
undetectable		 6djzA-5aukA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bs5 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		4 SER A 486
GLN A 483
GLU A 503
THR A 524
 None
 1.38A 6djzA-5bs5A:
undetectable		 6djzA-5bs5A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ec0 ALP7A

(Bacillus
subtilis) 		no annotation 4 SER A  13
ASP A   9
GLU A 180
THR A 217
 ADP  A 403 (-4.1A)
MG  A 404 ( 4.1A)
MG  A 404 (-4.2A)
None
 1.12A 6djzA-5ec0A:
undetectable		 6djzA-5ec0A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 SER A 219
GLN A 197
GLU A 629
THR A 225
 None
 1.43A 6djzA-5fjiA:
undetectable		 6djzA-5fjiA:
14.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hk2 SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1

(Homo sapiens) 		PF04622
(ERG2_Sigma1R) 		6 SER A 117
TYR A 120
ASP A 126
GLN A 135
GLU A 172
THR A 181
 61V  A 301 (-2.9A)
None
61V  A 301 (-3.2A)
None
61V  A 301 (-2.9A)
61V  A 301 ( 4.7A)
 0.56A 6djzA-5hk2A:
34.9		 6djzA-5hk2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kin TRYPTOPHAN SYNTHASE
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00291
(PALP) 		4 SER B  38
ASP B 207
GLN B  45
GLU B 203
 None
 1.42A 6djzA-5kinB:
undetectable		 6djzA-5kinB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l75 FIG000906: PREDICTED
PERMEASE

(Klebsiella
pneumoniae) 		PF03739
(YjgP_YjgQ) 		4 SER G 277
ASP G 247
GLN G  65
THR G 330
 None
 1.36A 6djzA-5l75G:
undetectable		 6djzA-5l75G:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opf CHITIN-BINDING
DOMAIN 3 PROTEIN

(Micromonospora
aurantiaca) 		no annotation 4 SER A 163
TYR A 158
ASP A 102
THR A 154
 None
 1.47A 6djzA-5opfA:
undetectable		 6djzA-5opfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6f LPXTG-MOTIF CELL
WALL ANCHOR DOMAIN
PROTEIN

(Mobiluncus
mulieris) 		no annotation 4 SER A 161
ASP A 117
GLN A  53
GLU A 165
 None
 1.50A 6djzA-5u6fA:
undetectable		 6djzA-5u6fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhj 26S PROTEASOME
REGULATORY SUBUNIT 8

(Homo sapiens) 		PF00004
(AAA) 		4 ASP C 394
GLN C 392
GLU C 358
THR C 364
 None
 1.33A 6djzA-5vhjC:
undetectable		 6djzA-5vhjC:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3f TUBULIN ALPHA-1
CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		4 SER A 380
TYR A 313
GLN A 302
THR A 350
 None
 1.48A 6djzA-5w3fA:
undetectable		 6djzA-5w3fA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7u TREHALOSE SYNTHASE

(Thermobaculum
terrenum) 		no annotation 4 ASP A 202
GLN A 170
GLU A 244
THR A 313
 TRS  A 600 (-2.8A)
TRS  A 600 ( 4.5A)
TRS  A 600 (-2.7A)
None
 1.29A 6djzA-5x7uA:
undetectable		 6djzA-5x7uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb7 BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		no annotation 4 TYR A  85
ASP A 278
GLN A 260
GLU A 311
 None
GOL  A 802 (-4.2A)
None
GOL  A 802 (-2.4A)
 1.48A 6djzA-5xb7A:
undetectable		 6djzA-5xb7A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xru ADENYLATE KINASE

(Notothenia
coriiceps) 		no annotation 4 SER A  19
ASP A  93
GLN A  24
THR A 157
 AP5  A 201 (-3.5A)
AP5  A 201 ( 4.7A)
None
None
 1.47A 6djzA-5xruA:
undetectable		 6djzA-5xruA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ay4 CYP51, STEROL
14ALPHA-DEMETHYLASE

(Naegleria
fowleri) 		no annotation 4 SER A 299
ASP A 176
GLN A 295
THR A 475
 None
None
EDO  A 505 (-3.8A)
None
 1.50A 6djzA-6ay4A:
undetectable		 6djzA-6ay4A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cg0 V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Mus musculus) 		no annotation 4 SER A 979
ASP A 986
GLN A 978
GLU A 985
 None
 1.43A 6djzA-6cg0A:
undetectable		 6djzA-6cg0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu0 TRANSCRIPTION FACTOR
IIIB 70 KDA SUBUNIT

(Saccharomyces
cerevisiae) 		no annotation 4 SER Z 271
ASP Z 279
GLU Z 281
THR Z 265
 None
 1.39A 6djzA-6eu0Z:
undetectable		 6djzA-6eu0Z:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC2

(Saccharomyces
cerevisiae) 		no annotation 4 SER B 963
TYR B 690
ASP B 986
THR B 977
 None
 1.42A 6djzA-6f42B:
undetectable		 6djzA-6f42B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1

(Homo sapiens) 		no annotation 4 SER A 582
ASP A 596
GLN A 603
GLU A 594
 None
 1.39A 6djzA-6f9nA:
undetectable		 6djzA-6f9nA:
undetectable