SIMILAR PATTERNS OF AMINO ACIDS FOR 6DJZ_A_GMJA301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5z L-LACTATE
DEHYDROGENASE


(Thermotoga
maritima)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 PHE A 315
VAL A 289
VAL A 281
LEU A 113
ALA A 325
None
1.19A 6djzA-1a5zA:
undetectable
6djzA-1a5zA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbh PROTEIN (HUMAN SOS
1)


(Homo sapiens)
PF00169
(PH)
PF00621
(RhoGEF)
5 MET A 538
LEU A 541
ILE A 461
HIS A 460
ALA A 528
None
1.20A 6djzA-1dbhA:
0.0
6djzA-1dbhA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8r L-AMINO ACID OXIDASE

(Calloselasma
rhodostoma)
PF01593
(Amino_oxidase)
5 LEU A  52
ILE A 291
VAL A 271
LEU A 482
ALA A 483
None
1.13A 6djzA-1f8rA:
0.0
6djzA-1f8rA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fu1 DNA REPAIR PROTEIN
XRCC4


(Homo sapiens)
PF06632
(XRCC4)
5 LEU A  28
ILE A  34
LEU A 108
ALA A  73
TYR A  66
None
None
ACY  A 501 ( 4.9A)
None
None
1.08A 6djzA-1fu1A:
undetectable
6djzA-1fu1A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fu1 DNA REPAIR PROTEIN
XRCC4


(Homo sapiens)
PF06632
(XRCC4)
5 LEU A  28
ILE A  34
THR A  37
LEU A 108
TYR A  66
None
None
None
ACY  A 501 ( 4.9A)
None
1.24A 6djzA-1fu1A:
undetectable
6djzA-1fu1A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
5 LEU A 403
ILE A 231
VAL A 418
LEU A 360
ALA A 363
None
1.23A 6djzA-1g8kA:
0.0
6djzA-1g8kA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gae D-GLYCERALDEHYDE-3-P
HOSPHATE
DEHYDROGENASE


(Escherichia
coli)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 ILE O   5
VAL O  73
VAL O  66
ALA O  18
TYR O 317
None
None
None
None
NAD  O 336 ( 3.9A)
1.09A 6djzA-1gaeO:
undetectable
6djzA-1gaeO:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ikp EXOTOXIN A

(Pseudomonas
aeruginosa)
PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target)
5 LEU A 597
ILE A 471
VAL A 566
HIS A 440
THR A 442
None
1.17A 6djzA-1ikpA:
0.0
6djzA-1ikpA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k72 ENDOGLUCANASE 9G

([Clostridium]
cellulolyticum)
PF00759
(Glyco_hydro_9)
PF00942
(CBM_3)
5 LEU A 588
PHE A 495
VAL A 479
THR A 526
VAL A 545
None
1.21A 6djzA-1k72A:
1.6
6djzA-1k72A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l7v VITAMIN B12
TRANSPORT
ATP-BINDING PROTEIN
BTUD


(Escherichia
coli)
PF00005
(ABC_tran)
5 MET C 188
LEU C 157
ILE C 144
PHE C  58
VAL C   4
None
1.04A 6djzA-1l7vC:
0.0
6djzA-1l7vC:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lq2 BETA-D-GLUCAN
GLUCOHYDROLASE
ISOENZYME EXO1


(Hordeum vulgare)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
5 LEU A 406
THR A 508
VAL A 512
LEU A 391
ALA A 539
None
1.18A 6djzA-1lq2A:
undetectable
6djzA-1lq2A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luj CATENIN BETA-1

(Homo sapiens)
PF00514
(Arm)
5 LEU A 498
ILE A 569
VAL A 564
LEU A 577
ALA A 576
None
1.21A 6djzA-1lujA:
undetectable
6djzA-1lujA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7j D-AMINOACYLASE

(Alcaligenes
faecalis)
PF07969
(Amidohydro_3)
5 PHE A 413
VAL A  92
HIS A  67
VAL A 247
TYR A 389
None
None
ZN  A 802 ( 3.2A)
None
None
1.07A 6djzA-1m7jA:
undetectable
6djzA-1m7jA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2


(Synechocystis
sp. PCC 6803)
PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central)
5 TYR A 196
LEU A 191
ILE A 173
LEU A  17
ALA A 201
None
1.23A 6djzA-1ofeA:
undetectable
6djzA-1ofeA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE


(Escherichia
coli)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
5 ILE A  41
THR A  55
VAL A  57
LEU A  74
ALA A  70
None
1.14A 6djzA-1oj4A:
undetectable
6djzA-1oj4A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sbp SULFATE-BINDING
PROTEIN


(Salmonella
enterica)
PF13531
(SBP_bac_11)
5 TYR A 242
LEU A 243
VAL A 229
VAL A  52
LEU A  16
None
1.20A 6djzA-1sbpA:
undetectable
6djzA-1sbpA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmi PUTATIVE PHOSPHATE
ACETYLTRANSFERASE


(Escherichia
coli)
PF01515
(PTA_PTB)
6 ILE A 120
HIS A 301
VAL A 111
LEU A  39
ALA A  40
TYR A  33
None
1.40A 6djzA-1vmiA:
undetectable
6djzA-1vmiA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1


(Homo sapiens)
PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF)
5 MET A 538
LEU A 541
ILE A 461
HIS A 460
ALA A 528
None
1.19A 6djzA-1xdvA:
undetectable
6djzA-1xdvA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrz PROTEIN KINASE C,
IOTA


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
5 LEU A 430
ILE A 507
VAL A 516
LEU A 360
ALA A 356
None
1.18A 6djzA-1zrzA:
undetectable
6djzA-1zrzA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON


(Salmonella
enterica)
PF01569
(PAP2)
5 TYR A 161
VAL A  91
THR A 100
VAL A 229
TYR A 116
None
1.00A 6djzA-2akcA:
undetectable
6djzA-2akcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE


(Corynebacterium
callunae)
PF00343
(Phosphorylase)
5 MET A 307
PHE A 349
VAL A 258
VAL A 392
ALA A 401
None
1.19A 6djzA-2c4mA:
undetectable
6djzA-2c4mA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ral SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN G


(Staphylococcus
epidermidis)
PF10425
(SdrG_C_C)
5 LEU A 497
PHE A 530
VAL A 488
VAL A 467
TYR A 424
None
1.08A 6djzA-2ralA:
undetectable
6djzA-2ralA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w31 GLOBIN

(Geobacter
sulfurreducens)
PF11563
(Protoglobin)
5 TYR A  82
LEU A  86
ILE A 138
THR A 114
VAL A 110
None
1.02A 6djzA-2w31A:
undetectable
6djzA-2w31A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1


(Gracilariopsis
lemaneiformis)
PF01055
(Glyco_hydro_31)
5 LEU A 344
PHE A 138
VAL A  79
THR A 153
VAL A 145
None
1.10A 6djzA-2x2iA:
undetectable
6djzA-2x2iA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N


(Thermosynechococcus
elongatus)
PF00148
(Oxidored_nitro)
5 LEU A  88
ILE A 101
VAL A  27
LEU A 119
TYR A  82
None
1.21A 6djzA-2xdqA:
undetectable
6djzA-2xdqA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8i PA4872 OXALOACETATE
DECARBOXYLASE


(Pseudomonas
aeruginosa)
PF13714
(PEP_mutase)
5 VAL A 210
THR A 115
LEU A  64
ALA A  63
TYR A 275
None
1.18A 6djzA-3b8iA:
undetectable
6djzA-3b8iA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5y RIBOSE/GALACTOSE
ISOMERASE


(Novosphingobium
aromaticivorans)
PF02502
(LacAB_rpiB)
PF12408
(DUF3666)
5 ILE A   3
HIS A  31
LEU A 127
ALA A  21
TYR A 115
None
1.17A 6djzA-3c5yA:
undetectable
6djzA-3c5yA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY


(Ruegeria
pomeroyi)
PF13377
(Peripla_BP_3)
5 TYR A 108
PHE A 167
VAL A 301
LEU A  78
TYR A 105
None
1.23A 6djzA-3e3mA:
undetectable
6djzA-3e3mA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3en0 CYANOPHYCINASE

(Synechocystis
sp. PCC 6803)
PF03575
(Peptidase_S51)
5 LEU A 184
PHE A 207
VAL A 166
VAL A 213
LEU A 248
None
1.19A 6djzA-3en0A:
undetectable
6djzA-3en0A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etc AMP-BINDING PROTEIN

(Methanosarcina
acetivorans)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 LEU A 163
ILE A 127
VAL A 147
THR A 119
ALA A 134
None
1.15A 6djzA-3etcA:
undetectable
6djzA-3etcA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19


(Rhodobacter
sphaeroides)
PF01244
(Peptidase_M19)
5 MET A 134
LEU A 157
ILE A 142
LEU A  95
ALA A  94
None
1.12A 6djzA-3fdgA:
undetectable
6djzA-3fdgA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3io1 AMINOBENZOYL-GLUTAMA
TE UTILIZATION
PROTEIN


(Klebsiella
pneumoniae)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 PHE A 179
VAL A  39
VAL A 115
LEU A   4
ALA A 424
None
1.21A 6djzA-3io1A:
undetectable
6djzA-3io1A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isp HTH-TYPE
TRANSCRIPTIONAL
REGULATOR
RV1985C/MT2039


(Mycobacterium
tuberculosis)
PF00126
(HTH_1)
PF03466
(LysR_substrate)
5 ILE A  97
PHE A 110
VAL A 124
VAL A 113
ALA A 279
None
1.15A 6djzA-3ispA:
undetectable
6djzA-3ispA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isp HTH-TYPE
TRANSCRIPTIONAL
REGULATOR
RV1985C/MT2039


(Mycobacterium
tuberculosis)
PF00126
(HTH_1)
PF03466
(LysR_substrate)
5 ILE A  97
THR A 284
VAL A 113
LEU A 135
ALA A 100
None
1.20A 6djzA-3ispA:
undetectable
6djzA-3ispA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j09 COPPER-EXPORTING
P-TYPE ATPASE A


(Archaeoglobus
fulgidus)
PF00122
(E1-E2_ATPase)
PF00403
(HMA)
PF00702
(Hydrolase)
5 VAL A 280
HIS A 462
VAL A 487
LEU A 450
ALA A 453
None
1.16A 6djzA-3j09A:
1.8
6djzA-3j09A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jap EIF3A

(Saccharomyces
cerevisiae)
PF00411
(Ribosomal_S11)
5 LEU o 408
ILE o 390
VAL o 432
LEU o 330
TYR o 416
None
1.23A 6djzA-3japo:
undetectable
6djzA-3japo:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mud DNA REPAIR PROTEIN
XRCC4,TROPOMYOSIN
ALPHA-1 CHAIN


(Gallus gallus;
Homo sapiens)
PF06632
(XRCC4)
5 LEU A  28
ILE A  34
LEU A 108
ALA A  73
TYR A  66
None
1.00A 6djzA-3mudA:
undetectable
6djzA-3mudA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4f DNA REPAIR PROTEIN
XRCC4


(Homo sapiens)
PF06632
(XRCC4)
5 LEU C  28
ILE C  34
LEU C 108
ALA C  73
TYR C  66
None
1.18A 6djzA-3q4fC:
undetectable
6djzA-3q4fC:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ren GLYCOSYL HYDROLASE,
FAMILY 8


(Clostridium
perfringens)
PF01270
(Glyco_hydro_8)
5 LEU A 312
ILE A 327
PHE A 280
LEU A 363
TYR A  92
None
None
None
None
EDO  A 373 (-4.8A)
1.22A 6djzA-3renA:
undetectable
6djzA-3renA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rof LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE PTPA


(Staphylococcus
aureus)
PF01451
(LMWPc)
5 ILE A 142
PHE A   6
VAL A  83
ALA A 149
TYR A  -3
None
1.06A 6djzA-3rofA:
undetectable
6djzA-3rofA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5t PUTATIVE
GLYCOSYLTRANSFERASE


(Streptomyces
hygroscopicus)
PF00982
(Glyco_transf_20)
5 LEU A  30
ILE A  80
VAL A  45
LEU A  84
ALA A  52
None
1.23A 6djzA-3t5tA:
undetectable
6djzA-3t5tA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqp ENOLASE

(Coxiella
burnetii)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 MET A 144
LEU A 404
ILE A 375
THR A 347
VAL A 351
None
1.18A 6djzA-3tqpA:
undetectable
6djzA-3tqpA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w03 DNA REPAIR PROTEIN
XRCC4


(Homo sapiens)
PF06632
(XRCC4)
5 LEU C  28
ILE C  34
LEU C 108
ALA C  73
TYR C  66
None
1.08A 6djzA-3w03C:
undetectable
6djzA-3w03C:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w03 DNA REPAIR PROTEIN
XRCC4


(Homo sapiens)
PF06632
(XRCC4)
5 LEU C  28
ILE C  34
THR C  37
LEU C 108
TYR C  66
None
1.24A 6djzA-3w03C:
undetectable
6djzA-3w03C:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3we9 PUTATIVE
PHYTOENE/SQUALENE
SYNTHASE YISP


(Bacillus
subtilis)
PF00494
(SQS_PSY)
5 ILE A 248
HIS A 253
THR A 202
LEU A 216
ALA A 212
None
1.04A 6djzA-3we9A:
undetectable
6djzA-3we9A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wec CYTOCHROME P450

(Rhodococcus
erythropolis)
PF00067
(p450)
5 ILE A 286
PHE A 269
VAL A 344
LEU A 132
ALA A 135
None
1.22A 6djzA-3wecA:
undetectable
6djzA-3wecA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zk4 DIPHOSPHONUCLEOTIDE
PHOSPHATASE 1


(Lupinus luteus)
PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N)
5 LEU A 550
ILE A 431
VAL A 422
LEU A 504
TYR A 500
None
1.02A 6djzA-3zk4A:
undetectable
6djzA-3zk4A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9w MONOOXYGENASE

(Stenotrophomonas
maltophilia)
PF13738
(Pyr_redox_3)
5 ILE A 125
VAL A 317
VAL A 111
LEU A  91
TYR A  85
None
1.13A 6djzA-4a9wA:
undetectable
6djzA-4a9wA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A


(Saccharomyces
cerevisiae)
PF16787
(NDC10_II)
5 TYR A 332
LEU A 324
PHE A 205
VAL A 345
LEU A 226
None
1.16A 6djzA-4acoA:
undetectable
6djzA-4acoA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce7 UNSATURATED
3S-RHAMNOGLYCURONYL
HYDROLASE


(Nonlabens
ulvanivorans)
PF07470
(Glyco_hydro_88)
5 LEU A 352
ILE A  26
LEU A  70
ALA A  69
TYR A  99
None
1.24A 6djzA-4ce7A:
undetectable
6djzA-4ce7A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4chc POLYMERASE ACIDIC
PROTEIN


(Thogoto
thogotovirus)
no annotation 5 LEU A 100
ILE A  41
VAL A  12
LEU A 149
ALA A 148
None
1.18A 6djzA-4chcA:
undetectable
6djzA-4chcA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dsh UDP-GALACTOPYRANOSE
MUTASE


(Trypanosoma
cruzi)
PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8)
5 PHE A 248
VAL A 254
HIS A  34
THR A 229
ALA A  21
None
1.13A 6djzA-4dshA:
undetectable
6djzA-4dshA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4h GLUTAMINE DEPENDENT
NAD+ SYNTHETASE


(Burkholderia
thailandensis)
PF00795
(CN_hydrolase)
PF02540
(NAD_synthase)
5 LEU A  84
ILE A 164
VAL A 168
LEU A  46
ALA A  45
None
1.02A 6djzA-4f4hA:
undetectable
6djzA-4f4hA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gji L-RHAMNOSE ISOMERASE

(Pseudomonas
stutzeri)
no annotation 5 TYR A 199
LEU A 200
HIS A 220
LEU A 216
ALA A 249
None
1.22A 6djzA-4gjiA:
undetectable
6djzA-4gjiA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnk 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3


(Homo sapiens)
PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like)
5 VAL B 823
THR B 842
VAL B 730
LEU B 791
ALA B 792
None
1.23A 6djzA-4gnkB:
undetectable
6djzA-4gnkB:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ii2 UBIQUITIN-CONJUGATIN
G ENZYME E2 4


(Schizosaccharomyces
pombe)
PF00179
(UQ_con)
5 LEU C 103
ILE C  54
VAL C  26
HIS C  55
LEU C  86
None
1.16A 6djzA-4ii2C:
undetectable
6djzA-4ii2C:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN


(Escherichia
coli;
Homo sapiens)
PF01273
(LBP_BPI_CETP)
PF13416
(SBP_bac_8)
5 LEU A1234
ILE A1163
PHE A1252
VAL A1253
LEU A1059
None
1.21A 6djzA-4kegA:
undetectable
6djzA-4kegA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5w CALCIUM-BINDING
MITOCHONDRIAL
CARRIER PROTEIN
ARALAR2,CALCIUM-BIND
ING MITOCHONDRIAL
CARRIER PROTEIN
ARALAR2


(Homo sapiens)
no annotation 5 ILE A 650
PHE A  99
THR A 119
VAL A 115
LEU A  45
None
1.10A 6djzA-4p5wA:
undetectable
6djzA-4p5wA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE


(Roseobacter
denitrificans)
PF03480
(DctP)
5 LEU A 215
ILE A  91
VAL A  66
LEU A 273
ALA A  42
CS2  A 401 (-4.2A)
None
None
None
None
1.18A 6djzA-4pc9A:
undetectable
6djzA-4pc9A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB


(Escherichia
coli)
PF07244
(POTRA)
PF13360
(PQQ_2)
5 LEU A1063
VAL A1162
THR A1145
VAL A1147
ALA A1109
None
1.22A 6djzA-4pk1A:
undetectable
6djzA-4pk1A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfu GLYCOSIDE HYDROLASE
FAMILY 5


(Bacteroides
vulgatus)
PF12904
(Collagen_bind_2)
PF13204
(DUF4038)
5 TYR A  75
ILE A 327
HIS A 324
VAL A 305
ALA A  82
None
1.08A 6djzA-4qfuA:
2.9
6djzA-4qfuA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3


(Homo sapiens)
PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like)
5 LEU B 685
VAL B 823
THR B 842
VAL B 730
LEU B 791
None
1.05A 6djzA-4qj4B:
undetectable
6djzA-4qj4B:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjk ACETOLACTATE
SYNTHASE


(Bacillus
subtilis)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 LEU A  96
PHE A 156
VAL A 152
VAL A  30
ALA A  64
None
1.03A 6djzA-4rjkA:
undetectable
6djzA-4rjkA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE


(Plasmodium
vivax)
PF00082
(Peptidase_S8)
5 ILE A 558
VAL A 562
LEU A 503
ALA A 527
TYR A 511
None
1.12A 6djzA-4tr2A:
undetectable
6djzA-4tr2A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upi SULFATASE FAMILY
PROTEIN


(Ruegeria
pomeroyi)
PF00884
(Sulfatase)
5 TYR A  23
LEU A  20
ILE A 354
PHE A 309
ALA A 327
None
1.11A 6djzA-4upiA:
undetectable
6djzA-4upiA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zd6 HALOHYDRIN EPOXIDASE
B


(Corynebacterium
sp.)
PF13561
(adh_short_C2)
5 ILE A  90
PHE A 158
VAL A 115
LEU A  82
ALA A 130
None
1.16A 6djzA-4zd6A:
undetectable
6djzA-4zd6A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi5 P91

(metagenome)
PF01738
(DLH)
5 PHE A 182
VAL A 178
THR A 139
VAL A 159
ALA A 132
None
1.15A 6djzA-4zi5A:
undetectable
6djzA-4zi5A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a60 INORGANIC
TRIPHOSPHATASE


(Escherichia
coli)
PF01928
(CYTH)
5 LEU A 313
HIS A 263
THR A 373
LEU A 225
ALA A 228
None
1.20A 6djzA-5a60A:
undetectable
6djzA-5a60A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC


(Chlamydomonas
reinhardtii)
no annotation 5 LEU A 343
HIS A 297
VAL A 127
LEU A  82
ALA A  88
None
1.15A 6djzA-5b5xA:
undetectable
6djzA-5b5xA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN


(Nanoarchaeum
equitans)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn)
5 LEU A 207
ILE A 376
VAL A 398
THR A 322
VAL A 379
None
1.24A 6djzA-5bn4A:
undetectable
6djzA-5bn4A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN


(Staphylococcus
aureus)
PF10425
(SdrG_C_C)
5 LEU A 230
PHE A 264
VAL A 221
VAL A 191
TYR A 148
None
1.21A 6djzA-5cfaA:
undetectable
6djzA-5cfaA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chx XRCC4-MYH7-1590-1657

(Homo sapiens)
PF01576
(Myosin_tail_1)
PF06632
(XRCC4)
5 LEU A  28
ILE A  34
LEU A 108
ALA A  73
TYR A  66
None
None
MLY  A  99 ( 4.5A)
MLY  A  72 ( 3.6A)
None
1.07A 6djzA-5chxA:
undetectable
6djzA-5chxA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cj0 XRCC4-MYH7-(1631-169
2) CHIMERA PROTEIN


(Homo sapiens)
PF06632
(XRCC4)
5 LEU A  28
ILE A  34
LEU A 108
ALA A  73
TYR A  66
None
1.11A 6djzA-5cj0A:
undetectable
6djzA-5cj0A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cj4 XRCC4-MYH7-(1562-162
2) CHIMERA PROTEIN


(Homo sapiens)
PF06632
(XRCC4)
5 LEU A  28
ILE A  34
LEU A 108
ALA A  73
TYR A  66
None
None
MLY  A  99 ( 4.8A)
MLY  A  72 ( 3.6A)
None
1.12A 6djzA-5cj4A:
undetectable
6djzA-5cj4A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME


(Homo sapiens)
PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48)
5 LEU A 663
THR A 640
VAL A 638
ALA A 692
TYR A 657
None
1.13A 6djzA-5clwA:
undetectable
6djzA-5clwA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfw SINGLE CHAIN FV
FRAGMENT


(Mus musculus)
PF07686
(V-set)
5 TYR H 602
LEU H 612
PHE H 152
HIS H 199
LEU H 598
None
0.98A 6djzA-5dfwH:
undetectable
6djzA-5dfwH:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e44 FNR REGULATOR

(Aliivibrio
fischeri)
PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2)
5 LEU A 239
ILE A 231
PHE A 181
THR A 194
LEU A 214
None
1.19A 6djzA-5e44A:
3.8
6djzA-5e44A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foi MYCINAMICIN VIII C21
METHYL HYDROXYLASE


(Micromonospora
griseorubida)
PF00067
(p450)
5 ILE A 273
HIS A 271
THR A 242
LEU A 136
ALA A 135
None
1.24A 6djzA-5foiA:
undetectable
6djzA-5foiA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h05 AMYP

(marine
metagenome)
PF00128
(Alpha-amylase)
5 LEU A 390
PHE A 258
VAL A 437
VAL A 254
LEU A  58
None
1.22A 6djzA-5h05A:
undetectable
6djzA-5h05A:
16.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hk2 SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1


(Homo sapiens)
PF04622
(ERG2_Sigma1R)
6 ILE A 124
PHE A 133
VAL A 152
HIS A 154
THR A 160
ALA A  86
61V  A 301 ( 4.7A)
None
None
61V  A 301 ( 4.1A)
None
None
1.00A 6djzA-5hk2A:
34.9
6djzA-5hk2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hk2 SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1


(Homo sapiens)
PF04622
(ERG2_Sigma1R)
9 MET A  93
LEU A 105
PHE A 133
VAL A 152
HIS A 154
THR A 160
VAL A 162
LEU A 186
ALA A 185
61V  A 301 (-3.4A)
None
None
None
61V  A 301 ( 4.1A)
None
None
None
61V  A 301 ( 4.2A)
1.49A 6djzA-5hk2A:
34.9
6djzA-5hk2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hk2 SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1


(Homo sapiens)
PF04622
(ERG2_Sigma1R)
12 MET A  93
TYR A 103
LEU A 105
ILE A 124
PHE A 133
VAL A 152
HIS A 154
THR A 160
VAL A 162
LEU A 182
ALA A 185
TYR A 206
61V  A 301 (-3.4A)
61V  A 301 ( 4.3A)
None
61V  A 301 ( 4.7A)
None
None
61V  A 301 ( 4.1A)
None
None
None
61V  A 301 ( 4.2A)
61V  A 301 (-3.6A)
0.58A 6djzA-5hk2A:
34.9
6djzA-5hk2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hk2 SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1


(Homo sapiens)
PF04622
(ERG2_Sigma1R)
6 PHE A 133
VAL A 152
HIS A 154
THR A 160
LEU A 186
ALA A  86
None
None
61V  A 301 ( 4.1A)
None
None
None
0.95A 6djzA-5hk2A:
34.9
6djzA-5hk2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihe DNA POLYMERASE II
SMALL SUBUNIT


(Pyrococcus
abyssi)
PF00149
(Metallophos)
5 LEU A 435
ILE A 358
VAL A 396
LEU A 374
TYR A 177
None
1.06A 6djzA-5iheA:
undetectable
6djzA-5iheA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irm UNCHARACTERIZED
PROTEIN


(Oryctolagus
cuniculus)
PF05729
(NACHT)
PF13516
(LRR_6)
5 TYR A 232
HIS A 293
THR A 357
VAL A 402
TYR A 435
ADP  A1101 (-3.4A)
None
None
None
ADP  A1101 (-4.6A)
1.23A 6djzA-5irmA:
undetectable
6djzA-5irmA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko9 EMBRYONIC STEM
CELL-SPECIFIC
5-HYDROXYMETHYLCYTOS
INE-BINDING PROTEIN


(Homo sapiens)
PF02586
(SRAP)
5 LEU A 238
ILE A 179
THR A  94
LEU A 217
ALA A 215
None
1.13A 6djzA-5ko9A:
undetectable
6djzA-5ko9A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lw6 DDB_G0293866

(Dictyostelium
discoideum)
no annotation 5 LEU A 129
THR A 210
VAL A 155
LEU A 107
ALA A  23
None
1.20A 6djzA-5lw6A:
undetectable
6djzA-5lw6A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2


(Leishmania
infantum)
no annotation 5 LEU A  93
ILE A 126
HIS A 144
ALA A  73
TYR A  87
None
0.99A 6djzA-5ol0A:
undetectable
6djzA-5ol0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE


(Bacteroides
thetaiotaomicron)
no annotation 5 ILE A 313
HIS A 381
THR A 340
VAL A 394
LEU A 332
None
1.14A 6djzA-5opjA:
undetectable
6djzA-5opjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td7 ZGC:55652

(Danio rerio)
PF00850
(Hist_deacetyl)
5 MET A  13
PHE A  97
VAL A  95
VAL A  74
ALA A 109
None
1.20A 6djzA-5td7A:
undetectable
6djzA-5td7A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Acinetobacter
baumannii)
PF00275
(EPSP_synthase)
5 ILE A  39
THR A  70
VAL A  44
LEU A  78
TYR A 105
None
1.20A 6djzA-5u4hA:
undetectable
6djzA-5u4hA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Acinetobacter
baumannii)
PF00275
(EPSP_synthase)
5 LEU A 195
PHE A 159
VAL A 157
LEU A 222
ALA A 175
None
1.15A 6djzA-5u4hA:
undetectable
6djzA-5u4hA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7n CYTOCHROME C OXIDASE
SUBUNIT 2


(Thermus
thermophilus)
no annotation 5 ILE A 103
PHE A 116
VAL A 135
THR A 121
VAL A 118
None
1.16A 6djzA-5u7nA:
undetectable
6djzA-5u7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wj7 DNA REPAIR PROTEIN
XRCC4,MYOSIN-7


(Homo sapiens)
PF06632
(XRCC4)
5 LEU A  28
ILE A  34
LEU A 108
ALA A  73
TYR A  66
None
1.22A 6djzA-5wj7A:
undetectable
6djzA-5wj7A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlz DNA REPAIR PROTEIN
XRCC4,MYOSIN-7


(Homo sapiens)
no annotation 5 LEU C  28
ILE C  34
LEU C 108
ALA C  73
TYR C  66
None
1.18A 6djzA-5wlzC:
undetectable
6djzA-5wlzC:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES


(Staphylococcus
aureus)
no annotation 5 LEU A 394
ILE A 351
THR A 465
VAL A 469
LEU A 525
None
0.95A 6djzA-5xt3A:
undetectable
6djzA-5xt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY


(Paracoccus
laeviglucosivorans)
no annotation 5 ILE A 357
PHE A 372
VAL A 210
LEU A 263
TYR A 135
None
None
None
None
8S0  A 402 (-4.5A)
0.95A 6djzA-5yapA:
undetectable
6djzA-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnf PHOSPHOETHANOLAMINE
TRANSFERASE


(Moraxella sp.
HMSC061H09)
no annotation 5 ILE A 343
PHE A 560
VAL A 351
VAL A 267
TYR A 331
None
1.10A 6djzA-6bnfA:
undetectable
6djzA-6bnfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dd6 PHOTOLYASE PHRB

(Agrobacterium
tumefaciens)
no annotation 5 LEU A  12
PHE A  83
VAL A  34
VAL A 109
TYR A 271
None
DLZ  A 602 (-4.2A)
DLZ  A 602 (-4.6A)
None
None
1.09A 6djzA-6dd6A:
undetectable
6djzA-6dd6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gsa -

(-)
no annotation 5 TYR E 332
LEU E 324
PHE E 205
VAL E 345
LEU E 226
None
1.16A 6djzA-6gsaE:
undetectable
6djzA-6gsaE:
undetectable