SIMILAR PATTERNS OF AMINO ACIDS FOR 6DH0_A_017A101_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1anu COHESIN-2

(Ruminiclostridium
thermocellum) 		PF00963
(Cohesin) 		3 LEU A  78
ASP A  50
ILE A  99
 None
 0.60A 6dh0B-1anuA:
0.0		 6dh0B-1anuA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ece ENDOCELLULASE E1

(Acidothermus
cellulolyticus) 		PF00150
(Cellulase) 		3 LEU A 109
ASP A  15
ILE A  13
 None
 0.42A 6dh0B-1eceA:
undetectable		 6dh0B-1eceA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpz CYCLIN-DEPENDENT
KINASE INHIBITOR 3

(Homo sapiens) 		PF05706
(CDKN3) 		3 LEU A 149
ASP A 169
ILE A 162
 None
 0.52A 6dh0B-1fpzA:
0.0		 6dh0B-1fpzA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gv0 MALATE DEHYDROGENASE

(Chlorobaculum
tepidum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 LEU A 121
ASP A 299
ILE A 259
 NAD  A1306 ( 4.1A)
None
None
 0.52A 6dh0B-1gv0A:
undetectable		 6dh0B-1gv0A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE

(Escherichia
coli) 		PF00982
(Glyco_transf_20) 		3 LEU A 181
ASP A 130
ILE A  27
 None
G6P  A 901 (-3.3A)
None
 0.60A 6dh0B-1gz5A:
0.0		 6dh0B-1gz5A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3g CYCLOMALTODEXTRINASE

(Flavobacterium
sp. 92) 		PF00128
(Alpha-amylase)
PF09087
(Cyc-maltodext_N)
PF10438
(Cyc-maltodext_C) 		3 LEU A 410
ASP A 107
ILE A 216
 None
 0.59A 6dh0B-1h3gA:
0.0		 6dh0B-1h3gA:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h71 SERRALYSIN

(Pseudomonas sp.
'TAC II 18') 		PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		3 LEU P 436
ASP P 362
ILE P 355
 None
CA  P 505 ( 2.4A)
None
 0.57A 6dh0B-1h71P:
0.0		 6dh0B-1h71P:
9.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		3 LEU A  23
ASP A  29
ILE A  47
 A79  A 800 ( 3.8A)
A79  A 800 (-2.8A)
A79  A 800 ( 3.2A)
 0.51A 6dh0B-1hvcA:
14.3		 6dh0B-1hvcA:
42.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		3 LEU A  23
ASP A  29
ILE A  47
 A79  A 800 ( 4.0A)
A79  A 800 (-2.7A)
A79  A 800 ( 3.4A)
 0.49A 6dh0B-1hvcA:
14.3		 6dh0B-1hvcA:
42.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i3u ANTIBODY VHH LAMA
DOMAIN

(Lama glama) 		PF07686
(V-set) 		3 LEU A  20
ASP A  78
ILE A  29
 None
 0.63A 6dh0B-1i3uA:
0.0		 6dh0B-1i3uA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyx ENOLASE

(Enterococcus
hirae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 LEU A  50
ASP A  13
ILE A  11
 None
 0.61A 6dh0B-1iyxA:
undetectable		 6dh0B-1iyxA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1klp MEROMYCOLATE
EXTENSION ACYL
CARRIER PROTEIN

(Mycobacterium
tuberculosis) 		PF00550
(PP-binding) 		3 LEU A  67
ASP A  36
ILE A  27
 None
 0.62A 6dh0B-1klpA:
undetectable		 6dh0B-1klpA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum) 		no annotation 3 LEU T  50
ASP T  68
ILE T  72
 None
 0.54A 6dh0B-1lthT:
undetectable		 6dh0B-1lthT:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzk HEROIN ESTERASE

(Rhodococcus sp.) 		PF07859
(Abhydrolase_3) 		3 LEU A 109
ASP A 150
ILE A 154
 None
 0.61A 6dh0B-1lzkA:
undetectable		 6dh0B-1lzkA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfp LUXF GENE PRODUCT

(Photobacterium
leiognathi) 		PF00296
(Bac_luciferase) 		3 LEU A 195
ASP A 215
ILE A  34
 None
 0.65A 6dh0B-1nfpA:
undetectable		 6dh0B-1nfpA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nlr ENDO-1,4-BETA-GLUCAN
ASE

(Streptomyces
lividans) 		PF01670
(Glyco_hydro_12) 		3 LEU A 188
ASP A 104
ILE A 123
 None
MHO  A 122 ( 3.8A)
MHO  A 122 ( 4.0A)
 0.60A 6dh0B-1nlrA:
undetectable		 6dh0B-1nlrA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p31 UDP-N-ACETYLMURAMATE
--ALANINE LIGASE

(Haemophilus
influenzae) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 LEU A 330
ASP A 452
ILE A 369
 None
 0.64A 6dh0B-1p31A:
undetectable		 6dh0B-1p31A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxy FIMBRIN-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF00307
(CH) 		3 LEU A 590
ASP A 179
ILE A 183
 None
 0.63A 6dh0B-1pxyA:
undetectable		 6dh0B-1pxyA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
CYTOCHROME C OXIDASE
POLYPEPTIDE III

(Paracoccus
denitrificans;
Paracoccus
denitrificans) 		PF00115
(COX1)
PF00510
(COX3) 		3 LEU A 149
ASP A 180
ILE C  38
 None
 0.59A 6dh0B-1qleA:
undetectable		 6dh0B-1qleA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r45 MONO-ADP-RIBOSYLTRAN
SFERASE C3

(Clostridium
phage c-st) 		PF03496
(ADPrib_exo_Tox) 		3 LEU A 216
ASP A 166
ILE A 224
 None
 0.55A 6dh0B-1r45A:
undetectable		 6dh0B-1r45A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sk4 PEPTIDOGLYCAN
RECOGNITION PROTEIN
I-ALPHA

(Homo sapiens) 		PF01510
(Amidase_2) 		3 LEU A 245
ASP A 296
ILE A 298
 None
 0.65A 6dh0B-1sk4A:
undetectable		 6dh0B-1sk4A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un9 DIHYDROXYACETONE
KINASE

(Citrobacter
freundii) 		PF02733
(Dak1)
PF02734
(Dak2) 		3 LEU A 157
ASP A 140
ILE A 219
 None
 0.59A 6dh0B-1un9A:
undetectable		 6dh0B-1un9A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtz RIBOSE-5-PHOSPHATE
ISOMERASE

(Saccharomyces
cerevisiae) 		PF06026
(Rib_5-P_isom_A) 		3 LEU A 153
ASP A 209
ILE A 163
 None
 0.65A 6dh0B-1xtzA:
undetectable		 6dh0B-1xtzA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yo6 PUTATIVE CARBONYL
REDUCTASE SNIFFER

(Caenorhabditis
elegans) 		PF00106
(adh_short) 		3 LEU A 225
ASP A  26
ILE A  32
 None
 0.63A 6dh0B-1yo6A:
undetectable		 6dh0B-1yo6A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1z MINOR TAIL PROTEIN U

(Escherichia
virus Lambda) 		PF06141
(Phage_tail_U) 		3 LEU A   6
ASP A  97
ILE A  99
 None
 0.64A 6dh0B-1z1zA:
undetectable		 6dh0B-1z1zA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztc HYPOTHETICAL PROTEIN
TM0894

(Thermotoga
maritima) 		PF00753
(Lactamase_B) 		3 LEU A  42
ASP A  38
ILE A  36
 None
 0.57A 6dh0B-1ztcA:
undetectable		 6dh0B-1ztcA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztm FUSION GLYCOPROTEIN

(Human
respirovirus 3) 		PF00523
(Fusion_gly) 		3 LEU A  49
ASP A 270
ILE A  79
 None
 0.62A 6dh0B-1ztmA:
undetectable		 6dh0B-1ztmA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeh FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M) 		3 LEU A 129
ASP A 295
ILE A 280
 None
 0.60A 6dh0B-2aehA:
undetectable		 6dh0B-2aehA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpa PROTEIN (SUBUNIT OF
BACTERIOPHAGE
PHIX174)

(Escherichia
virus phiX174) 		PF02305
(Phage_F) 		3 LEU 1 400
ASP 1 389
ILE 1 385
 None
 0.65A 6dh0B-2bpa1:
undetectable		 6dh0B-2bpa1:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfo GLUTAMYL-TRNA
SYNTHETASE

(Synechococcus
elongatus) 		PF00749
(tRNA-synt_1c) 		3 LEU A 370
ASP A 260
ILE A 258
 None
 0.60A 6dh0B-2cfoA:
undetectable		 6dh0B-2cfoA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		3 LEU A 277
ASP A 233
ILE A 243
 None
 0.43A 6dh0B-2dh4A:
undetectable		 6dh0B-2dh4A:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8m RIBOSE 5-PHOSPHATE
ISOMERASE

(Plasmodium
falciparum) 		PF06026
(Rib_5-P_isom_A) 		3 LEU A 130
ASP A 183
ILE A 138
 None
 0.57A 6dh0B-2f8mA:
undetectable		 6dh0B-2f8mA:
22.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fmb EQUINE INFECTIOUS
ANEMIA VIRUS
PROTEASE

(Equine
infectious
anemia virus) 		PF00077
(RVP) 		3 LEU A  23
ASP A  29
ILE A  53
 None
LP1  A 201 (-3.6A)
LP1  A 201 (-4.6A)
 0.61A 6dh0B-2fmbA:
15.1		 6dh0B-2fmbA:
31.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		3 LEU A 248
ASP A 188
ILE A 186
 None
 0.63A 6dh0B-2gjxA:
undetectable		 6dh0B-2gjxA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Caldanaerobacter
subterraneus) 		PF13407
(Peripla_BP_4) 		3 LEU A  62
ASP A  52
ILE A  54
 None
 0.64A 6dh0B-2ioyA:
undetectable		 6dh0B-2ioyA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		3 LEU A 350
ASP A 295
ILE A 280
 None
 0.61A 6dh0B-2j0jA:
undetectable		 6dh0B-2j0jA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A  48
ASP A  86
ILE A  19
 None
 0.57A 6dh0B-2jc6A:
undetectable		 6dh0B-2jc6A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kom PARTITIONING
DEFECTIVE 3 HOMOLOG

(Homo sapiens) 		PF00595
(PDZ) 		3 LEU A 494
ASP A 502
ILE A 462
 None
 0.55A 6dh0B-2komA:
undetectable		 6dh0B-2komA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l14 CELLULAR TUMOR
ANTIGEN P53

(Homo sapiens) 		PF08563
(P53_TAD) 		3 LEU B  43
ASP B  48
ILE B  50
 None
 0.47A 6dh0B-2l14B:
undetectable		 6dh0B-2l14B:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n1g DNA REPAIR PROTEIN
REV1

(Homo sapiens) 		PF16727
(REV1_C) 		3 LEU A1208
ASP A1196
ILE A1198
 None
 0.61A 6dh0B-2n1gA:
undetectable		 6dh0B-2n1gA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n5z RESUSCITATION-PROMOT
ING FACTOR RPFC

(Mycobacterium
tuberculosis) 		PF06737
(Transglycosylas) 		3 LEU A  82
ASP A  10
ILE A  58
 None
 0.65A 6dh0B-2n5zA:
undetectable		 6dh0B-2n5zA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA

(Vibrio cholerae) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		3 LEU A  92
ASP A 436
ILE A 434
 None
 0.53A 6dh0B-2nx9A:
undetectable		 6dh0B-2nx9A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxf PUTATIVE DIMETAL
PHOSPHATASE

(Danio rerio) 		PF00149
(Metallophos) 		3 LEU A  76
ASP A  13
ILE A  11
 None
ZN  A 401 (-3.1A)
None
 0.56A 6dh0B-2nxfA:
undetectable		 6dh0B-2nxfA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1w ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 LEU A 510
ASP A 477
ILE A 475
 None
 0.62A 6dh0B-2o1wA:
undetectable		 6dh0B-2o1wA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogp PARTITIONING-DEFECTI
VE 3 HOMOLOG

(Rattus
norvegicus) 		PF00595
(PDZ) 		3 LEU A  57
ASP A  65
ILE A  25
 None
 0.65A 6dh0B-2ogpA:
undetectable		 6dh0B-2ogpA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oux MAGNESIUM
TRANSPORTER

(Enterococcus
faecalis) 		PF00571
(CBS)
PF03448
(MgtE_N) 		3 LEU A 232
ASP A 254
ILE A 141
 None
 0.61A 6dh0B-2ouxA:
undetectable		 6dh0B-2ouxA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa6 ENOLASE

(Methanocaldococcus
jannaschii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 LEU A 346
ASP A  89
ILE A  11
 None
 0.57A 6dh0B-2pa6A:
undetectable		 6dh0B-2pa6A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzk PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE

(Bordetella
bronchiseptica) 		PF01370
(Epimerase) 		3 LEU A 111
ASP A 209
ILE A 207
 None
 0.56A 6dh0B-2pzkA:
undetectable		 6dh0B-2pzkA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxx DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE

(Mycobacterium
tuberculosis) 		PF00692
(dUTPase) 		3 LEU A  36
ASP A  23
ILE A  32
 None
 0.65A 6dh0B-2qxxA:
undetectable		 6dh0B-2qxxA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfo NUCLEOPORIN NIC96

(Saccharomyces
cerevisiae) 		PF04097
(Nic96) 		3 LEU A 660
ASP A 765
ILE A 767
 None
 0.52A 6dh0B-2rfoA:
undetectable		 6dh0B-2rfoA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri0 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Streptococcus
mutans) 		PF01182
(Glucosamine_iso) 		3 LEU A  40
ASP A 226
ILE A 224
 None
 0.62A 6dh0B-2ri0A:
undetectable		 6dh0B-2ri0A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2toh TYROSINE
3-MONOOXYGENASE

(Rattus
norvegicus) 		PF00351
(Biopterin_H) 		3 LEU A 354
ASP A 471
ILE A 476
 None
 0.51A 6dh0B-2tohA:
undetectable		 6dh0B-2tohA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1c RECOMBINATION
PROTEIN RECR

(Deinococcus
radiodurans) 		PF02132
(RecR)
PF13662
(Toprim_4) 		3 LEU A  47
ASP A  65
ILE A  63
 None
 0.55A 6dh0B-2v1cA:
undetectable		 6dh0B-2v1cA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7y CHAPERONE PROTEIN
DNAK

(Geobacillus
kaustophilus) 		PF00012
(HSP70) 		3 LEU A 209
ASP A 224
ILE A  58
 None
 0.65A 6dh0B-2v7yA:
undetectable		 6dh0B-2v7yA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vc6 DIHYDRODIPICOLINATE
SYNTHASE

(Sinorhizobium
meliloti) 		PF00701
(DHDPS) 		3 LEU A 100
ASP A 122
ILE A 150
 MCL  A 161 ( 4.7A)
None
None
 0.61A 6dh0B-2vc6A:
undetectable		 6dh0B-2vc6A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wda PUTATIVE SECRETED
LYASE

(Streptomyces
violaceoruber) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		3 LEU A 368
ASP A 297
ILE A 295
 None
 0.59A 6dh0B-2wdaA:
undetectable		 6dh0B-2wdaA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xlr FLAVIN-CONTAINING
MONOOXYGENASE

(Methylophaga
aminisulfidivorans) 		PF00743
(FMO-like) 		3 LEU A  75
ASP A 193
ILE A 274
 None
 0.62A 6dh0B-2xlrA:
undetectable		 6dh0B-2xlrA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		3 LEU A 196
ASP A 236
ILE A 316
 None
 0.52A 6dh0B-2ycbA:
undetectable		 6dh0B-2ycbA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yz2 PUTATIVE ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0222

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		3 LEU A  28
ASP A  67
ILE A  76
 None
 0.61A 6dh0B-2yz2A:
undetectable		 6dh0B-2yz2A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zba TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E

(Fusarium
sporotrichioides) 		PF02458
(Transferase) 		3 LEU A 317
ASP A 174
ILE A 176
 None
 0.62A 6dh0B-2zbaA:
undetectable		 6dh0B-2zbaA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus) 		PF00067
(p450) 		3 LEU A 284
ASP A 292
ILE A 396
 None
 0.62A 6dh0B-2zbzA:
undetectable		 6dh0B-2zbzA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buu UNCHARACTERIZED LOLA
SUPERFAMILY PROTEIN
NE2245

(Nitrosomonas
europaea) 		PF17131
(LolA_like) 		3 LEU A 148
ASP A 157
ILE A 153
 None
 0.57A 6dh0B-3buuA:
undetectable		 6dh0B-3buuA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bw8 MONO-ADP-RIBOSYLTRAN
SFERASE C3

(Hathewaya
limosa) 		PF03496
(ADPrib_exo_Tox) 		3 LEU A 177
ASP A 126
ILE A 185
 None
 0.62A 6dh0B-3bw8A:
undetectable		 6dh0B-3bw8A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm0 MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH RACK1

(Escherichia
coli;
Arabidopsis
thaliana) 		PF00400
(WD40)
PF01547
(SBP_bac_1) 		3 LEU A1007
ASP A1271
ILE A1260
 None
 0.61A 6dh0B-3dm0A:
undetectable		 6dh0B-3dm0A:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fqd PROTEIN DIN1

(Schizosaccharomyces
pombe) 		PF08652
(RAI1) 		3 LEU B 235
ASP B 201
ILE B 273
 None
MG  B1000 (-2.8A)
None
 0.48A 6dh0B-3fqdB:
undetectable		 6dh0B-3fqdB:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		3 LEU A 484
ASP A 651
ILE A 416
 None
 0.48A 6dh0B-3gcwA:
undetectable		 6dh0B-3gcwA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 LEU A 451
ASP A  92
ILE A 834
 None
 0.65A 6dh0B-3hhdA:
undetectable		 6dh0B-3hhdA:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A

(Bartonella
henselae) 		PF06026
(Rib_5-P_isom_A) 		3 LEU A 149
ASP A 203
ILE A 156
 None
 0.60A 6dh0B-3hheA:
undetectable		 6dh0B-3hheA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrr AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE

(Aspergillus
parasiticus) 		PF14765
(PS-DH) 		3 LEU A1528
ASP A1543
ILE A1545
 None
 0.58A 6dh0B-3hrrA:
undetectable		 6dh0B-3hrrA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig3 PLXNA3 PROTEIN

(Mus musculus) 		PF08337
(Plexin_cytopl) 		3 LEU A1377
ASP A1804
ILE A1802
 None
 0.62A 6dh0B-3ig3A:
undetectable		 6dh0B-3ig3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb4 VP1

(Parechovirus B) 		no annotation 3 LEU A 130
ASP A  85
ILE A  87
 None
 0.63A 6dh0B-3jb4A:
undetectable		 6dh0B-3jb4A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Danio rerio) 		PF12940
(RAG1) 		3 LEU A 958
ASP A 814
ILE A 975
 None
 0.40A 6dh0B-3jbyA:
undetectable		 6dh0B-3jbyA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtl PROTEASOME SUBUNIT
BETA

(Thermoplasma
acidophilum) 		PF00227
(Proteasome) 		3 LEU H  55
ASP H  38
ILE H  76
 None
 0.62A 6dh0B-3jtlH:
undetectable		 6dh0B-3jtlH:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4x PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		3 LEU A 784
ASP A 668
ILE A 696
 None
 0.64A 6dh0B-3k4xA:
undetectable		 6dh0B-3k4xA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl9 GLUTAMYL
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF05343
(Peptidase_M42) 		3 LEU A 330
ASP A 252
ILE A 250
 None
 0.64A 6dh0B-3kl9A:
undetectable		 6dh0B-3kl9A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksr PUTATIVE SERINE
HYDROLASE

(Xanthomonas
campestris) 		PF00326
(Peptidase_S9) 		3 LEU A  53
ASP A  98
ILE A 102
 None
 0.53A 6dh0B-3ksrA:
undetectable		 6dh0B-3ksrA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6n METALLO-BETA-LACTAMA
SE

(Chryseobacterium
indologenes) 		PF00753
(Lactamase_B) 		3 LEU A 233
ASP A 187
ILE A 191
 None
 0.64A 6dh0B-3l6nA:
undetectable		 6dh0B-3l6nA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Sulfolobus
solfataricus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		3 LEU A 261
ASP A 228
ILE A 231
 None
 0.59A 6dh0B-3l7zA:
undetectable		 6dh0B-3l7zA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lke ENOYL-COA HYDRATASE

(Bacillus
halodurans) 		PF00378
(ECH_1) 		3 LEU A 182
ASP A 124
ILE A  97
 None
 0.59A 6dh0B-3lkeA:
undetectable		 6dh0B-3lkeA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lss SERYL-TRNA
SYNTHETASE

(Trypanosoma
brucei) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		3 LEU A 350
ASP A 371
ILE A 338
 None
ATP  A 501 ( 4.5A)
None
 0.62A 6dh0B-3lssA:
undetectable		 6dh0B-3lssA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE

(Saccharomyces
cerevisiae) 		PF00282
(Pyridoxal_deC) 		3 LEU C 345
ASP C 365
ILE C 325
 None
 0.63A 6dh0B-3mc6C:
undetectable		 6dh0B-3mc6C:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		3 LEU A 179
ASP A 265
ILE A 204
 None
 0.63A 6dh0B-3mdyA:
undetectable		 6dh0B-3mdyA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mlx HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 3074 FAB
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 LEU H  20
ASP H  72
ILE H  29
 None
 0.63A 6dh0B-3mlxH:
undetectable		 6dh0B-3mlxH:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmw ENDOGLUCANASE

(Thermotoga
maritima) 		PF00150
(Cellulase) 		3 LEU A 114
ASP A 161
ILE A 166
 None
 0.65A 6dh0B-3mmwA:
undetectable		 6dh0B-3mmwA:
13.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mws HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		3 LEU A  23
ASP A  29
ILE A  47
 None
 0.51A 6dh0B-3mwsA:
20.0		 6dh0B-3mwsA:
75.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6x PUTATIVE
GLUTATHIONYLSPERMIDI
NE SYNTHASE

(Methylobacillus
flagellatus) 		PF14403
(CP_ATPgrasp_2) 		3 LEU A 284
ASP A 278
ILE A 276
 None
None
GOL  A 481 (-4.6A)
 0.63A 6dh0B-3n6xA:
undetectable		 6dh0B-3n6xA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA

(Escherichia
coli) 		PF00873
(ACR_tran) 		3 LEU A 478
ASP A  37
ILE A 335
 None
 0.45A 6dh0B-3ne5A:
undetectable		 6dh0B-3ne5A:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfv ALGINATE LYASE

(Bacteroides
ovatus) 		PF05426
(Alginate_lyase) 		3 LEU A 304
ASP A 245
ILE A 265
 None
 0.55A 6dh0B-3nfvA:
undetectable		 6dh0B-3nfvA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nke PROTEIN YGBT

(Escherichia
coli) 		PF01867
(Cas_Cas1) 		3 LEU A 187
ASP A 244
ILE A 235
 None
SO4  A   5 (-3.7A)
None
 0.52A 6dh0B-3nkeA:
undetectable		 6dh0B-3nkeA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nro LMO1026 PROTEIN

(Listeria
monocytogenes) 		PF03816
(LytR_cpsA_psr) 		3 LEU A 195
ASP A 165
ILE A 158
 None
 0.63A 6dh0B-3nroA:
undetectable		 6dh0B-3nroA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzu PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		3 LEU A 843
ASP A 964
ILE A 879
 None
NZU  A   1 (-4.1A)
NZU  A   1 (-4.2A)
 0.60A 6dh0B-3nzuA:
undetectable		 6dh0B-3nzuA:
6.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaa ATP SYNTHASE SUBUNIT
BETA

(Escherichia
coli) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		3 LEU D 162
ASP D 236
ILE D 290
 None
 0.65A 6dh0B-3oaaD:
undetectable		 6dh0B-3oaaD:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohg UNCHARACTERIZED
PROTEIN FROM DUF2233
FAMILY

(Bacteroides
ovatus) 		PF09992
(NAGPA) 		3 LEU A 269
ASP A 237
ILE A  78
 None
 0.64A 6dh0B-3ohgA:
undetectable		 6dh0B-3ohgA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p02 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF14274
(DUF4361)
PF16343
(DUF4973) 		3 LEU A 188
ASP A 292
ILE A 290
 None
 0.65A 6dh0B-3p02A:
undetectable		 6dh0B-3p02A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3peh ENDOPLASMIN HOMOLOG

(Plasmodium
falciparum) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 LEU A 255
ASP A 262
ILE A 264
 None
 0.53A 6dh0B-3pehA:
undetectable		 6dh0B-3pehA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q62 3-HYDROXYDECANOYL-[A
CYL-CARRIER-PROTEIN]
DEHYDRATASE

(Yersinia pestis) 		PF07977
(FabA) 		3 LEU A 107
ASP A 145
ILE A 129
 MES  A 173 (-4.8A)
None
None
 0.65A 6dh0B-3q62A:
undetectable		 6dh0B-3q62A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qoc PUTATIVE
METALLOPEPTIDASE

(Corynebacterium
diphtheriae) 		PF01321
(Creatinase_N) 		3 LEU A  50
ASP A  63
ILE A  67
 None
 0.52A 6dh0B-3qocA:
undetectable		 6dh0B-3qocA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT

(Legionella
pneumophila) 		PF01596
(Methyltransf_3) 		3 LEU A 122
ASP A 143
ILE A 168
 None
 0.59A 6dh0B-3r3hA:
undetectable		 6dh0B-3r3hA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfr PMOB

(Methylocystis
sp. M) 		PF04744
(Monooxygenase_B) 		3 LEU A 236
ASP A 226
ILE A 224
 None
 0.46A 6dh0B-3rfrA:
undetectable		 6dh0B-3rfrA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhg PUTATIVE
PHOPHOTRIESTERASE

(Proteus
mirabilis) 		PF02126
(PTE) 		3 LEU A 114
ASP A  94
ILE A 105
 None
 0.65A 6dh0B-3rhgA:
undetectable		 6dh0B-3rhgA:
12.15