SIMILAR PATTERNS OF AMINO ACIDS FOR 6DEB_B_MTXB303_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4i METHYLENETETRAHYDROF
OLATE DEHYDROGENASE
/
METHENYLTETRAHYDROFO
LATE CYCLOHYDROLASE

(Homo sapiens) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 TYR A  52
LYS A  56
GLN A 100
GLY A 217
ILE A 238
 None
None
None
NDP  A 302 (-3.3A)
NDP  A 302 (-4.4A)
 0.52A 6debB-1a4iA:
41.5		 6debB-1a4iA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ae9 LAMBDA INTEGRASE

(Escherichia
virus Lambda) 		PF00589
(Phage_integrase) 		4 TYR A 318
GLN A 321
GLY A 227
ILE A 242
 None
 1.42A 6debB-1ae9A:
undetectable		 6debB-1ae9A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)

(Escherichia
coli) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 TYR A  50
LYS A  54
GLN A  98
GLY A 211
 None
 0.79A 6debB-1b0aA:
40.9		 6debB-1b0aA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)

(Escherichia
coli) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 TYR A  50
LYS A  54
GLY A 211
ILE A 232
 None
 0.85A 6debB-1b0aA:
40.9		 6debB-1b0aA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1y PROTEIN
(BETA-AMYLASE)

(Hordeum vulgare) 		PF01373
(Glyco_hydro_14) 		4 TYR A 236
GLN A 235
GLY A 313
ILE A 205
 None
 1.42A 6debB-1b1yA:
undetectable		 6debB-1b1yA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA

(Methanosarcina
barkeri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 TYR A1328
GLN A1505
GLY A1234
ILE A1115
 None
 1.43A 6debB-1e6yA:
undetectable		 6debB-1e6yA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hf2 SEPTUM
SITE-DETERMINING
PROTEIN MINC

(Thermotoga
maritima) 		PF03775
(MinC_C) 		4 TYR A  18
GLN A  19
GLY A  79
ILE A  49
 None
 1.35A 6debB-1hf2A:
undetectable		 6debB-1hf2A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I

(Escherichia
coli) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 TYR A 193
GLN A 216
GLY A 369
ILE A 427
 None
 1.24A 6debB-1k0gA:
undetectable		 6debB-1k0gA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 TYR A 315
GLN A 485
GLY A 220
ILE A 101
 None
 1.48A 6debB-1mroA:
undetectable		 6debB-1mroA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p7d INTEGRASE

(Escherichia
virus Lambda) 		PF00589
(Phage_integrase)
PF02899
(Phage_int_SAM_1) 		4 TYR A 318
GLN A 321
GLY A 227
ILE A 242
 None
 1.37A 6debB-1p7dA:
undetectable		 6debB-1p7dA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 TYR A 713
GLN A 711
GLY A 724
ILE A 715
 None
 1.47A 6debB-1po0A:
undetectable		 6debB-1po0A:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxy FIMBRIN-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF00307
(CH) 		4 TYR A 345
GLN A 131
GLY A 230
ILE A 236
 None
 1.21A 6debB-1pxyA:
undetectable		 6debB-1pxyA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio sp.
PA-44) 		PF00082
(Peptidase_S8) 		4 TYR A  22
LYS A  87
GLN A   1
ILE A  11
 None
 1.42A 6debB-1s2nA:
3.4		 6debB-1s2nA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF14519
(Macro_2) 		4 TYR A  96
GLN A  55
GLY A 187
ILE A 140
 None
APR  A 285 (-3.5A)
None
None
 1.08A 6debB-1txzA:
undetectable		 6debB-1txzA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlt 176AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE

(Sulfurisphaera
tokodaii) 		PF00908
(dTDP_sugar_isom) 		4 TYR A 130
LYS A  71
GLY A  55
ILE A  80
 None
 1.27A 6debB-1wltA:
undetectable		 6debB-1wltA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wza ALPHA-AMYLASE A

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase) 		4 TYR A 256
LYS A 124
GLY A 318
ILE A 321
 None
 1.46A 6debB-1wzaA:
undetectable		 6debB-1wzaA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xaj 3-DEHYDROQUINATE
SYNTHASE

(Staphylococcus
aureus) 		PF01761
(DHQ_synthase) 		4 TYR A 287
GLN A 290
GLY A 209
ILE A 194
 None
 0.93A 6debB-1xajA:
undetectable		 6debB-1xajA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3n ALGQ1

(Sphingomonas
sp. A1) 		PF01547
(SBP_bac_1) 		4 TYR A 393
GLN A 391
GLY A 138
ILE A 408
 None
BEM  A 494 (-3.6A)
None
None
 1.39A 6debB-1y3nA:
undetectable		 6debB-1y3nA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy7 STRINGENT STARVATION
PROTEIN A

(Yersinia pestis) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 TYR A 115
GLN A 119
GLY A  16
ILE A  20
 None
 1.32A 6debB-1yy7A:
undetectable		 6debB-1yy7A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA

(Mycobacterium
tuberculosis) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 TYR A 378
LYS A 380
GLY A 498
ILE A 472
 None
 1.39A 6debB-1zj9A:
undetectable		 6debB-1zj9A:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA

(Mycobacterium
tuberculosis) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 TYR A 378
LYS A 380
GLY A 508
ILE A 472
 None
 1.48A 6debB-1zj9A:
undetectable		 6debB-1zj9A:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahn THAUMATIN-LIKE
PROTEIN

(Prunus avium) 		PF00314
(Thaumatin) 		4 TYR A 216
GLN A 121
GLY A  98
ILE A  95
 None
 1.03A 6debB-2ahnA:
undetectable		 6debB-2ahnA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9u HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE

(Sulfurisphaera
tokodaii) 		PF00908
(dTDP_sugar_isom) 		4 TYR A 130
LYS A  71
GLY A  55
ILE A  80
 None
 1.27A 6debB-2b9uA:
undetectable		 6debB-2b9uA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE

(Mycobacterium
tuberculosis) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 TYR A  49
LYS A  53
GLN A  97
GLY A 212
 None
 0.91A 6debB-2c2yA:
39.6		 6debB-2c2yA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE

(Mycobacterium
tuberculosis) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 TYR A  49
LYS A  53
GLN A  97
GLY A 232
 None
 1.20A 6debB-2c2yA:
39.6		 6debB-2c2yA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cgj L-RHAMNULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 TYR A 124
GLN A 183
GLY A 264
ILE A 281
 None
 1.10A 6debB-2cgjA:
undetectable		 6debB-2cgjA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 TYR A 198
LYS A 189
GLN A 199
GLY A 509
 None
 1.15A 6debB-2fqdA:
undetectable		 6debB-2fqdA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjr MALATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LYS A  36
GLN A 255
GLY A 154
ILE A  87
 None
 1.36A 6debB-2hjrA:
undetectable		 6debB-2hjrA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htm PUTATIVE THIAMINE
BIOSYNTHESIS PROTEIN
THIS
THIAZOLE
BIOSYNTHESIS PROTEIN
THIG

(Thermus
thermophilus) 		PF02597
(ThiS)
PF05690
(ThiG) 		4 TYR A  22
GLN E  62
GLY A 188
ILE A 210
 None
 1.40A 6debB-2htmA:
undetectable		 6debB-2htmA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hy5 INTRACELLULAR SULFUR
OXIDATION PROTEIN
DSRF
PUTATIVE
SULFURTRANSFERASE
DSRE

(Allochromatium
vinosum) 		PF02635
(DrsE) 		4 TYR A  40
GLN A   6
GLY B 218
ILE B 220
 None
 1.46A 6debB-2hy5A:
undetectable		 6debB-2hy5A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3x REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 1

(Rattus
norvegicus) 		PF00168
(C2) 		4 TYR A1527
GLN A1529
GLY A1577
ILE A1465
 None
 1.34A 6debB-2q3xA:
undetectable		 6debB-2q3xA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmw PREPHENATE
DEHYDRATASE

(Staphylococcus
aureus) 		PF00800
(PDT) 		4 TYR A 114
GLN A 117
GLY A 138
ILE A 156
 None
 1.48A 6debB-2qmwA:
undetectable		 6debB-2qmwA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qnu UNCHARACTERIZED
PROTEIN PA0076

(Pseudomonas
aeruginosa) 		PF09867
(DUF2094) 		4 TYR A  52
GLN A  41
GLY A  14
ILE A  80
 None
None
None
ACT  A 228 ( 4.6A)
 1.29A 6debB-2qnuA:
undetectable		 6debB-2qnuA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rag DIPEPTIDASE

(Caulobacter
vibrioides) 		PF01244
(Peptidase_M19) 		4 TYR A 207
GLN A 237
GLY A 276
ILE A 225
 None
 1.35A 6debB-2ragA:
undetectable		 6debB-2ragA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
3

(Mus musculus) 		PF06470
(SMC_hinge) 		4 TYR B 531
GLN B 528
GLY B 582
ILE B 508
 None
 1.47A 6debB-2wd5B:
undetectable		 6debB-2wd5B:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		4 TYR A 349
GLN A 348
GLY A 506
ILE A 494
 None
 1.35A 6debB-2x05A:
undetectable		 6debB-2x05A:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA

(Escherichia
coli) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		4 LYS A 469
GLN A 537
GLY A  89
ILE A 544
 None
 1.34A 6debB-3cp2A:
undetectable		 6debB-3cp2A:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 TYR A 551
GLN A 552
GLY A 808
ILE A 810
 None
 1.22A 6debB-3dy5A:
undetectable		 6debB-3dy5A:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehk PRUNIN

(Prunus dulcis) 		PF00190
(Cupin_1) 		4 LYS A 221
GLN A  70
GLY A  77
ILE A  55
 None
 1.43A 6debB-3ehkA:
undetectable		 6debB-3ehkA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		4 TYR A 670
GLN A 683
GLY A 731
ILE A 651
 None
 1.44A 6debB-3ihyA:
undetectable		 6debB-3ihyA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9d OUTER CAPSID PROTEIN
VP2

(Bluetongue
virus) 		PF00898
(Orbi_VP2) 		4 TYR A  49
GLN A 116
GLY A 852
ILE A 854
 None
 1.31A 6debB-3j9dA:
undetectable		 6debB-3j9dA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jur EXO-POLY-ALPHA-D-GAL
ACTURONOSIDASE

(Thermotoga
maritima) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		4 TYR A 196
GLN A 194
GLY A 307
ILE A 276
 None
 1.24A 6debB-3jurA:
undetectable		 6debB-3jurA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0s DNA MISMATCH REPAIR
PROTEIN MUTS

(Escherichia
coli) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 LYS A 245
GLN A 212
GLY A 224
ILE A 258
 None
 1.34A 6debB-3k0sA:
undetectable		 6debB-3k0sA:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkj AMINE OXIDASE,
FLAVIN-CONTAINING

(Pseudomonas
syringae group
genomosp. 3) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		4 LYS A 219
GLN A  56
GLY A  11
ILE A 112
 None
None
FAD  A 401 (-2.9A)
None
 1.39A 6debB-3kkjA:
undetectable		 6debB-3kkjA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkj AMINE OXIDASE,
FLAVIN-CONTAINING

(Pseudomonas
syringae group
genomosp. 3) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		4 TYR A  57
LYS A 219
GLN A  56
GLY A 311
 FAD  A 401 (-4.4A)
None
None
None
 1.46A 6debB-3kkjA:
undetectable		 6debB-3kkjA:
13.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3l07 BIFUNCTIONAL PROTEIN
FOLD

(Francisella
tularensis) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 TYR A  48
LYS A  52
GLN A  96
GLY A 210
ILE A 231
 None
None
None
None
IMD  A 503 ( 4.6A)
 0.75A 6debB-3l07A:
42.2		 6debB-3l07A:
50.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n7c ABR034WP

(Eremothecium
gossypii) 		PF00638
(Ran_BP1) 		4 TYR A 567
GLN A 612
GLY A 586
ILE A 582
 None
 1.47A 6debB-3n7cA:
undetectable		 6debB-3n7cA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdk PHOSPHOGLUCOSAMINE
MUTASE

(Bacillus
anthracis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 TYR A 162
GLN A 165
GLY A 341
ILE A 336
 None
 1.49A 6debB-3pdkA:
3.3		 6debB-3pdkA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdn PUTATIVE THIOREDOXIN
PROTEIN

(Salmonella
enterica) 		PF00085
(Thioredoxin)
PF14559
(TPR_19)
PF14561
(TPR_20) 		4 TYR A  52
GLN A  55
GLY A  92
ILE A 102
 None
 1.46A 6debB-3qdnA:
undetectable		 6debB-3qdnA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qj4 RENALASE

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		4 LYS A 230
GLN A  61
GLY A  10
ILE A 114
 None
None
FAD  A 401 ( 3.7A)
None
 1.21A 6debB-3qj4A:
undetectable		 6debB-3qj4A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qj4 RENALASE

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		4 TYR A  62
LYS A 230
GLN A  61
GLY A 326
 FAD  A 401 (-4.8A)
None
None
None
 1.34A 6debB-3qj4A:
undetectable		 6debB-3qj4A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thw DNA MISMATCH REPAIR
PROTEIN MSH3

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05192
(MutS_III) 		4 TYR B 735
GLN B 734
GLY B 712
ILE B 717
 None
 1.40A 6debB-3thwB:
undetectable		 6debB-3thwB:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugv ENOLASE

(alpha
proteobacterium
BAL199) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LYS A  87
GLN A  77
GLY A  45
ILE A  40
 None
 1.18A 6debB-3ugvA:
undetectable		 6debB-3ugvA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm5 ALPHA-AMYLASE

(Oryzias latipes) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 TYR A 247
GLN A 232
GLY A 238
ILE A 242
 None
 1.46A 6debB-3vm5A:
undetectable		 6debB-3vm5A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voc BETA/ALPHA-AMYLASE

(Paenibacillus
polymyxa) 		PF01373
(Glyco_hydro_14) 		4 LYS A 352
GLN A 310
GLY A 301
ILE A 280
 None
 1.33A 6debB-3vocA:
undetectable		 6debB-3vocA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE

(Thermotoga
maritima) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		4 TYR A  19
LYS A  21
GLY A 264
ILE A 261
 AGS  A1393 (-4.8A)
AGS  A1393 (-2.3A)
None
AGS  A1393 ( 4.3A)
 1.31A 6debB-4a2bA:
undetectable		 6debB-4a2bA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2l TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		4 TYR A 718
GLN A 320
GLY A 326
ILE A  34
 None
 1.20A 6debB-4a2lA:
undetectable		 6debB-4a2lA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5o BIFUNCTIONAL PROTEIN
FOLD

(Pseudomonas
aeruginosa) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 TYR A  50
LYS A  54
GLN A  98
GLY A 211
 None
 0.88A 6debB-4a5oA:
36.8		 6debB-4a5oA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4afr METACASPASE

(Trypanosoma
brucei) 		PF00656
(Peptidase_C14) 		4 TYR A  17
GLN A 104
GLY A  59
ILE A 115
 None
 1.23A 6debB-4afrA:
2.5		 6debB-4afrA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b46 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		4 TYR A 183
GLN A 180
GLY A 112
ILE A 136
 GDP  A1368 (-3.5A)
None
GDP  A1368 (-3.5A)
GDP  A1368 ( 4.2A)
 1.22A 6debB-4b46A:
2.1		 6debB-4b46A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2t DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 TYR A 361
GLN A 366
GLY A 388
ILE A 383
 None
 1.47A 6debB-4c2tA:
undetectable		 6debB-4c2tA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 TYR A 361
GLN A 366
GLY A 388
ILE A 383
 None
 1.27A 6debB-4c30A:
undetectable		 6debB-4c30A:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d51 CYMA

(Klebsiella
oxytoca) 		PF16941
(CymA) 		4 TYR A 154
LYS A 182
GLY A  67
ILE A 111
 None
 1.39A 6debB-4d51A:
undetectable		 6debB-4d51A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkm AMPHIOXUS GREEN
FLUORESCENT PROTEIN,
GFPC1A

(Branchiostoma
floridae) 		PF01353
(GFP) 		4 TYR A  64
GLN A 212
GLY A  81
ILE A 111
 None
 1.47A 6debB-4dkmA:
undetectable		 6debB-4dkmA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4el8 GLYCOSIDE HYDROLASE
FAMILY 48

(Caldicellulosiruptor
bescii) 		PF02011
(Glyco_hydro_48) 		4 TYR A 506
GLN A 421
GLY A  10
ILE A 629
 None
 1.11A 6debB-4el8A:
undetectable		 6debB-4el8A:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f5x RNA-DIRECTED RNA
POLYMERASE

(Rotavirus A) 		PF02123
(RdRP_4)
PF12289
(Rotavirus_VP1) 		4 TYR W 469
GLN W 473
GLY W 450
ILE W 447
 None
 1.30A 6debB-4f5xW:
undetectable		 6debB-4f5xW:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6e SUPEROXIDE DISMUTASE
[MN], MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 TYR A 178
GLN A 179
GLY A  12
ILE A  18
 None
MLY  A 181 ( 3.9A)
None
None
 1.15A 6debB-4f6eA:
undetectable		 6debB-4f6eA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8l UNCHARACTERIZED
PROTEIN YHFS

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 TYR A 101
GLN A 277
GLY A 204
ILE A  79
 LLP  A 196 ( 3.4A)
LLP  A 196 ( 4.6A)
None
None
 1.47A 6debB-4j8lA:
2.4		 6debB-4j8lA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l22 PHOSPHORYLASE

(Streptococcus
mutans) 		PF00343
(Phosphorylase) 		4 LYS A 497
GLN A 593
GLY A 739
ILE A 415
 None
 1.42A 6debB-4l22A:
3.7		 6debB-4l22A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9m RAS GUANYL-RELEASING
PROTEIN 1

(Homo sapiens) 		PF00130
(C1_1)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF13405
(EF-hand_6) 		4 TYR A 421
GLN A 256
GLY A 537
ILE A 532
 None
 1.25A 6debB-4l9mA:
undetectable		 6debB-4l9mA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lx4 ENDOGLUCANASE(ENDO-1
,4-BETA-GLUCANASE)PR
OTEIN

(Pseudomonas
stutzeri) 		PF00150
(Cellulase) 		4 TYR A  47
GLN A  92
GLY A 254
ILE A 296
 None
 1.40A 6debB-4lx4A:
undetectable		 6debB-4lx4A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nre ARACHIDONATE
15-LIPOXYGENASE B

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 TYR A 154
LYS A 152
GLY A 424
ILE A 421
 None
 1.49A 6debB-4nreA:
undetectable		 6debB-4nreA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 TYR A 327
GLN A 601
GLY A 675
ILE A 627
 None
 1.24A 6debB-4o9xA:
undetectable		 6debB-4o9xA:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plf LACTATE
DEHYDROGENASE

(Apicomplexa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 TYR A 274
GLN A 273
GLY A 156
ILE A 183
 None
 1.45A 6debB-4plfA:
4.0		 6debB-4plfA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plh MALATE DEHYDROGENASE

(Apicomplexa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 TYR A 265
GLN A 264
GLY A 147
ILE A 174
 None
 1.46A 6debB-4plhA:
4.0		 6debB-4plhA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3m MGS-M4

(unidentified) 		PF00248
(Aldo_ket_red) 		4 TYR A 184
GLN A 158
GLY A 262
ILE A 265
 None
 1.40A 6debB-4q3mA:
undetectable		 6debB-4q3mA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)

(Agrobacterium
vitis) 		PF13407
(Peripla_BP_4) 		4 TYR A 265
GLN A 247
GLY A 234
ILE A 166
 None
 1.26A 6debB-4wt7A:
5.7		 6debB-4wt7A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Brucella ovis) 		PF00497
(SBP_bac_3) 		4 TYR A 101
GLN A 315
GLY A 296
ILE A 293
 None
 1.27A 6debB-4z9nA:
undetectable		 6debB-4z9nA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7d PINS

(Drosophila
melanogaster) 		PF13176
(TPR_7)
PF13424
(TPR_12) 		4 TYR B 360
GLN B 363
GLY B 305
ILE B 318
 None
 1.42A 6debB-5a7dB:
undetectable		 6debB-5a7dB:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 TYR A 317
GLN A 487
GLY A 223
ILE A 104
 None
 1.43A 6debB-5a8rA:
undetectable		 6debB-5a8rA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecj PR DOMAIN ZINC
FINGER PROTEIN
14,PROTEIN CBFA2T2

(Mus musculus) 		PF00856
(SET)
PF07531
(TAFH) 		4 TYR A 176
LYS A 178
GLY A  88
ILE A 154
 None
 1.31A 6debB-5ecjA:
undetectable		 6debB-5ecjA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h71 ALGQ2

(Sphingomonas
sp.) 		PF01547
(SBP_bac_1) 		4 TYR A 393
GLN A 391
GLY A 138
ILE A 408
 None
MAW  A 501 ( 3.7A)
None
None
 1.41A 6debB-5h71A:
undetectable		 6debB-5h71A:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN

(Trichodesmium
erythraeum) 		no annotation 4 TYR A 100
GLN A 207
GLY A 260
ILE A 136
 None
 1.44A 6debB-5jvbA:
undetectable		 6debB-5jvbA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n72 WIPA

(Legionella
pneumophila) 		no annotation 4 TYR A  61
GLN A  62
GLY A  33
ILE A  39
 None
 1.28A 6debB-5n72A:
undetectable		 6debB-5n72A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngv ANTI-HUMAN ACTRIIB
MAB BYM338
HEAVY-CHAIN

(Homo sapiens) 		no annotation 4 TYR H  60
GLN H  65
GLY H  99
ILE H  51
 None
 1.30A 6debB-5ngvH:
undetectable		 6debB-5ngvH:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2j PROBABLE PHOSPHITE
TRANSPORT
SYSTEM-BINDING
PROTEIN PTXB

(Pseudomonas
stutzeri) 		no annotation 4 TYR A  94
GLN A 202
GLY A 255
ILE A 130
 2PO  A 301 (-4.9A)
None
None
None
 1.31A 6debB-5o2jA:
undetectable		 6debB-5o2jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus) 		PF02538
(Hydantoinase_B) 		4 TYR A 288
GLN A 290
GLY A 423
ILE A 284
 None
 1.27A 6debB-5svcA:
undetectable		 6debB-5svcA:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 LYS A  88
GLN A 132
GLY A 255
ILE A 276
 L34  A 402 (-2.8A)
L34  A 402 (-3.4A)
NAD  A 401 (-3.2A)
NAD  A 401 ( 3.2A)
 0.95A 6debB-5tc4A:
41.6		 6debB-5tc4A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 TYR A  84
LYS A  88
GLN A 132
GLY A 255
 L34  A 402 (-3.4A)
L34  A 402 (-2.8A)
L34  A 402 (-3.4A)
NAD  A 401 (-3.2A)
 0.47A 6debB-5tc4A:
41.6		 6debB-5tc4A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 TYR A  84
LYS A  88
GLN A 132
GLY A 291
 L34  A 402 (-3.4A)
L34  A 402 (-2.8A)
L34  A 402 (-3.4A)
None
 1.49A 6debB-5tc4A:
41.6		 6debB-5tc4A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ane POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE

(Ideonella
sakaiensis) 		no annotation 4 TYR A  36
GLN A  99
GLY A  71
ILE A  82
 None
 1.48A 6debB-6aneA:
2.6		 6debB-6aneA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ape BIFUNCTIONAL PROTEIN
FOLD

(Helicobacter
pylori) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 TYR A  53
LYS A  57
GLN A 101
GLY A 212
ILE A 235
 None
GOL  A 305 (-2.7A)
None
GOL  A 303 (-3.6A)
GOL  A 303 (-4.7A)
 1.22A 6debB-6apeA:
44.0		 6debB-6apeA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ape BIFUNCTIONAL PROTEIN
FOLD

(Helicobacter
pylori) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 TYR A  53
LYS A  57
GLN A 101
GLY A 214
ILE A 235
 None
GOL  A 305 (-2.7A)
None
GOL  A 303 (-3.5A)
GOL  A 303 (-4.7A)
 0.77A 6debB-6apeA:
44.0		 6debB-6apeA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0e 1260 ANTIBODY, HEAVY
CHAIN

(Homo sapiens) 		no annotation 4 TYR B  59
GLN B  64
GLY B  97
ILE B  51
 None
 1.44A 6debB-6b0eB:
undetectable		 6debB-6b0eB:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c13 -

(-) 		no annotation 4 TYR A1045
GLN A1042
GLY A1079
ILE A1137
 None
 1.46A 6debB-6c13A:
undetectable		 6debB-6c13A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8v COENZYME PQQ
SYNTHESIS PROTEIN E

(Methylobacterium
extorquens) 		no annotation 4 TYR A 195
GLN A 194
GLY A 101
ILE A  98
 None
 1.45A 6debB-6c8vA:
undetectable		 6debB-6c8vA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Moorella
thermoacetica) 		no annotation 4 TYR A 998
GLN A1004
GLY A  64
ILE A 973
 HTL  A1204 (-4.5A)
None
None
None
 1.02A 6debB-6cipA:
2.5		 6debB-6cipA:
19.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6de8 BIFUNCTIONAL PROTEIN
FOLD

(Campylobacter
jejuni) 		no annotation 5 TYR A  47
LYS A  51
GLN A  95
GLY A 209
ILE A 230
 None
 0.57A 6debB-6de8A:
48.0		 6debB-6de8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eks SIALIDASE

(Vibrio cholerae) 		no annotation 4 TYR A 770
GLN A 771
GLY A 592
ILE A 578
 None
 1.41A 6debB-6eksA:
undetectable		 6debB-6eksA:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Cyanidioschyzon
merolae) 		no annotation 4 TYR A 368
GLN A 383
GLY A 507
ILE A 522
 None
None
None
CLA  A1135 ( 4.9A)
 1.45A 6debB-6fosA:
undetectable		 6debB-6fosA:
21.35