SIMILAR PATTERNS OF AMINO ACIDS FOR 6D9K_F_ACTF802_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bev | BOVINE ENTEROVIRUSCOAT PROTEINS VP1 TOVP4 (Enterovirus E) |
PF00073(Rhv) | 3 | TYR 2 170ALA 2 207LEU 2 158 | None | 0.68A | 6d9kF-1bev2:0.0 | 6d9kF-1bev2:15.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cmv | HUMANCYTOMEGALOVIRUSPROTEASE (Humanbetaherpesvirus5) |
PF00716(Peptidase_S21) | 3 | TYR A 128ALA A 67LEU A 221 | None | 0.74A | 6d9kF-1cmvA:undetectable | 6d9kF-1cmvA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1feh | PROTEIN (PERIPLASMICHYDROGENASE 1) (Clostridiumpasteurianum) |
PF02256(Fe_hyd_SSU)PF02906(Fe_hyd_lg_C)PF12838(Fer4_7)PF13510(Fer2_4) | 3 | TYR A 552ALA A 331LEU A 568 | None | 0.58A | 6d9kF-1fehA:2.9 | 6d9kF-1fehA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1imv | PIGMENTEPITHELIUM-DERIVEDFACTOR (Homo sapiens) |
PF00079(Serpin) | 3 | TYR A 102ALA A 385LEU A 63 | None | 0.71A | 6d9kF-1imvA:0.0 | 6d9kF-1imvA:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l3w | EP-CADHERIN (Xenopus laevis) |
PF00028(Cadherin) | 3 | TYR A 259ALA A 317LEU A 242 | None | 0.68A | 6d9kF-1l3wA:undetectable | 6d9kF-1l3wA:24.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lkf | LEUKOCIDIN F SUBUNIT (Staphylococcusaureus) |
PF07968(Leukocidin) | 3 | TYR A 245ALA A 25LEU A 36 | None | 0.75A | 6d9kF-1lkfA:undetectable | 6d9kF-1lkfA:16.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mke | FUSION PROTEINCONSISTING OFWISKOTT-ALDRICHSYNDROME PROTEININTERACTING PROTEIN(WIP), GSGSG LINKER,AND NEURALWISKOTT-ALDRICHSYNDROME PROTEIN(N-WASP) (Homo sapiens;Rattusnorvegicus) |
PF00568(WH1) | 3 | TYR A 102ALA A 135LEU A 69 | None | 0.76A | 6d9kF-1mkeA:undetectable | 6d9kF-1mkeA:11.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nw5 | MODIFICATIONMETHYLASE RSRI (Rhodobactersphaeroides) |
PF01555(N6_N4_Mtase) | 3 | TYR A 299ALA A 257LEU A 284 | None | 0.73A | 6d9kF-1nw5A:2.2 | 6d9kF-1nw5A:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pix | GLUTACONYL-COADECARBOXYLASE ASUBUNIT (Acidaminococcusfermentans) |
PF01039(Carboxyl_trans) | 3 | TYR A 320ALA A 479LEU A 451 | None | 0.52A | 6d9kF-1pixA:1.8 | 6d9kF-1pixA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pxv | CYSTEINE PROTEASE (Staphylococcusaureus) |
PF05543(Peptidase_C47) | 3 | TYR A 358ALA A 326LEU A 378 | None | 0.65A | 6d9kF-1pxvA:undetectable | 6d9kF-1pxvA:12.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5a | EP-CADHERIN (Mus musculus) |
PF00028(Cadherin) | 3 | TYR A 259ALA A 317LEU A 242 | None | 0.00A | 6d9kF-1q5aA:undetectable | 6d9kF-1q5aA:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qwy | PEPTIDOGLYCANHYDROLASE (Staphylococcusaureus) |
PF01551(Peptidase_M23) | 3 | TYR A 215ALA A 189LEU A 313 | None | 0.65A | 6d9kF-1qwyA:undetectable | 6d9kF-1qwyA:15.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rpn | GDP-MANNOSE4,6-DEHYDRATASE (Pseudomonasaeruginosa) |
PF16363(GDP_Man_Dehyd) | 3 | TYR A 55ALA A 19LEU A 44 | None | 0.64A | 6d9kF-1rpnA:2.2 | 6d9kF-1rpnA:18.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tf0 | SERUM ALBUMIN (Homo sapiens) |
PF00273(Serum_albumin) | 3 | TYR A 138ALA A 164LEU A 182 | None | 0.75A | 6d9kF-1tf0A:undetectable | 6d9kF-1tf0A:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tue | REPLICATION PROTEINE1 (Alphapapillomavirus7) |
PF00519(PPV_E1_C) | 3 | TYR A 538ALA A 546LEU A 517 | None | 0.66A | 6d9kF-1tueA:undetectable | 6d9kF-1tueA:15.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u2z | HISTONE-LYSINEN-METHYLTRANSFERASE,H3 LYSINE-79SPECIFIC (Saccharomycescerevisiae) |
PF08123(DOT1) | 3 | TYR A 435ALA A 410LEU A 449 | None | 0.68A | 6d9kF-1u2zA:undetectable | 6d9kF-1u2zA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ufa | TT1467 PROTEIN (Thermusthermophilus) |
PF03065(Glyco_hydro_57)PF09210(DUF1957) | 3 | TYR A 515ALA A 510LEU A 454 | None | 0.76A | 6d9kF-1ufaA:undetectable | 6d9kF-1ufaA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uiy | ENOYL-COA HYDRATASE (Thermusthermophilus) |
PF00378(ECH_1) | 3 | TYR A 129ALA A 148LEU A 174 | None | 0.69A | 6d9kF-1uiyA:undetectable | 6d9kF-1uiyA:17.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vcn | CTP SYNTHETASE (Thermusthermophilus) |
PF00117(GATase)PF06418(CTP_synth_N) | 3 | TYR A 460ALA A 492LEU A 519 | None | 0.69A | 6d9kF-1vcnA:4.5 | 6d9kF-1vcnA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yk9 | ADENYLATE CYCLASE (Mycobacteriumtuberculosis) |
PF00211(Guanylate_cyc) | 3 | TYR A 280ALA A 330LEU A 343 | None | 0.73A | 6d9kF-1yk9A:undetectable | 6d9kF-1yk9A:14.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zrt | CYTOCHROME B (Rhodobactercapsulatus) |
PF00032(Cytochrom_B_C)PF00033(Cytochrome_B) | 3 | TYR C 403ALA C 346LEU C 116 | None | 0.76A | 6d9kF-1zrtC:undetectable | 6d9kF-1zrtC:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aco | OUTER MEMBRANELIPOPROTEIN BLC (Escherichiacoli) |
PF08212(Lipocalin_2) | 3 | TYR A 116ALA A 62LEU A 141 | None | 0.70A | 6d9kF-2acoA:undetectable | 6d9kF-2acoA:13.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b44 | GLYCYL-GLYCINEENDOPEPTIDASE LYTM (Staphylococcusaureus) |
PF01551(Peptidase_M23) | 3 | TYR A 215ALA A 189LEU A 313 | None | 0.66A | 6d9kF-2b44A:undetectable | 6d9kF-2b44A:10.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bkx | GLUCOSAMINE-6-PHOSPHATE DEAMINASE (Bacillussubtilis) |
PF01182(Glucosamine_iso) | 3 | TYR A 44ALA A 16LEU A 130 | None | 0.73A | 6d9kF-2bkxA:undetectable | 6d9kF-2bkxA:15.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bvm | TOXIN B (Clostridioidesdifficile) |
PF12918(TcdB_N)PF12919(TcdA_TcdB) | 3 | TYR A 24ALA A 71LEU A 9 | None | 0.45A | 6d9kF-2bvmA:undetectable | 6d9kF-2bvmA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ec5 | DERMONECROTIC TOXIN (Pasteurellamultocida) |
PF11647(MLD) | 3 | TYR A 611ALA A 656LEU A 596 | None | 0.67A | 6d9kF-2ec5A:undetectable | 6d9kF-2ec5A:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jzn | MANNOSE-SPECIFICPHOSPHOTRANSFERASEENZYME IIA COMPONENT (Escherichiacoli) |
PF03610(EIIA-man) | 3 | TYR A 87ALA A 4LEU A 53 | None | 0.57A | 6d9kF-2jznA:4.2 | 6d9kF-2jznA:10.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2k6v | PUTATIVE CYTOCHROMEC OXIDASE ASSEMBLYPROTEIN (Thermusthermophilus) |
PF02630(SCO1-SenC) | 3 | TYR A 153ALA A 61LEU A 168 | None | 0.56A | 6d9kF-2k6vA:undetectable | 6d9kF-2k6vA:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p22 | SUPPRESSOR PROTEINSTP22 OFTEMPERATURE-SENSITIVE ALPHA-FACTORRECEPTOR ANDARGININE PERMEASEPROTEIN SRN2 (Saccharomycescerevisiae;Saccharomycescerevisiae) |
PF09454(Vps23_core)PF07200(Mod_r) | 3 | TYR C 213ALA A 318LEU C 150 | None | 0.71A | 6d9kF-2p22C:undetectable | 6d9kF-2p22C:13.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qfc | PLCR PROTEIN (Bacillusthuringiensis) |
PF01381(HTH_3) | 3 | TYR A 64ALA A 53LEU A 49 | None | 0.64A | 6d9kF-2qfcA:undetectable | 6d9kF-2qfcA:15.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r66 | GLYCOSYLTRANSFERASE, GROUP 1 (Halothermothrixorenii) |
PF00534(Glycos_transf_1)PF00862(Sucrose_synth) | 3 | TYR A 354ALA A 264LEU A 251 | None | 0.62A | 6d9kF-2r66A:2.5 | 6d9kF-2r66A:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r8w | AGR_C_1641P (Agrobacteriumfabrum) |
PF00701(DHDPS) | 3 | TYR A 222ALA A 234LEU A 207 | None | 0.76A | 6d9kF-2r8wA:undetectable | 6d9kF-2r8wA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uv8 | FATTY ACID SYNTHASESUBUNIT BETA (FAS1) (Saccharomycescerevisiae) |
PF00698(Acyl_transf_1)PF01575(MaoC_dehydratas)PF08354(DUF1729)PF13452(MaoC_dehydrat_N)PF16073(SAT) | 3 | TYR G 890ALA G 897LEU G 864 | None | 0.66A | 6d9kF-2uv8G:undetectable | 6d9kF-2uv8G:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vdt | LEVANSUCRASE (Bacillussubtilis) |
PF02435(Glyco_hydro_68) | 3 | TYR A 283ALA A 306LEU A 297 | None | 0.75A | 6d9kF-2vdtA:undetectable | 6d9kF-2vdtA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vl8 | CYTOTOXIN L (Paeniclostridiumsordellii) |
PF12918(TcdB_N)PF12919(TcdA_TcdB) | 3 | TYR A 24ALA A 71LEU A 9 | None | 0.50A | 6d9kF-2vl8A:undetectable | 6d9kF-2vl8A:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vqd | BIOTIN CARBOXYLASE (Pseudomonasaeruginosa) |
PF00289(Biotin_carb_N)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 3 | TYR A 60ALA A 14LEU A 39 | None | 0.74A | 6d9kF-2vqdA:4.3 | 6d9kF-2vqdA:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ww2 | ALPHA-1,2-MANNOSIDASE (Bacteroidesthetaiotaomicron) |
PF07971(Glyco_hydro_92) | 3 | TYR A 50ALA A 54LEU A 317 | GOL A 802 (-3.9A)NoneGOL A 802 (-4.8A) | 0.70A | 6d9kF-2ww2A:undetectable | 6d9kF-2ww2A:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y0k | PYROGLUTATMATE PORINOPDO (Pseudomonasaeruginosa) |
PF03573(OprD) | 3 | TYR A 201ALA A 227LEU A 116 | None | 0.68A | 6d9kF-2y0kA:undetectable | 6d9kF-2y0kA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yx0 | RADICAL SAM ENZYME (Pyrococcushorikoshii) |
PF04055(Radical_SAM)PF08608(Wyosine_form) | 3 | TYR A 125ALA A 139LEU A 44 | None | 0.72A | 6d9kF-2yx0A:undetectable | 6d9kF-2yx0A:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z1q | ACYL-COADEHYDROGENASE (Thermusthermophilus) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 3 | TYR A 513ALA A 319LEU A 357 | None | 0.75A | 6d9kF-2z1qA:undetectable | 6d9kF-2z1qA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z3t | CYTOCHROME P450 (Streptomycessp. TP-A0274) |
PF00067(p450) | 3 | TYR A 49ALA A 303LEU A 11 | None | 0.76A | 6d9kF-2z3tA:undetectable | 6d9kF-2z3tA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zc7 | BETA-LACTAMASE ACT-1 (Klebsiellapneumoniae) |
PF00144(Beta-lactamase) | 3 | TYR A 135ALA A 114LEU A 109 | None | 0.74A | 6d9kF-2zc7A:undetectable | 6d9kF-2zc7A:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zj9 | AMPC (Escherichiacoli) |
PF00144(Beta-lactamase) | 3 | TYR A 135ALA A 160LEU A 216 | None | 0.73A | 6d9kF-2zj9A:undetectable | 6d9kF-2zj9A:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3acp | WD REPEAT-CONTAININGPROTEIN YGL004C (Saccharomycescerevisiae) |
PF00400(WD40) | 3 | TYR A 390ALA A 344LEU A 414 | None | 0.77A | 6d9kF-3acpA:undetectable | 6d9kF-3acpA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b86 | GENERALODORANT-BINDINGPROTEIN LUSH (Drosophilamelanogaster) |
PF01395(PBP_GOBP) | 3 | TYR A 47ALA A 110LEU A 31 | None | 0.74A | 6d9kF-3b86A:undetectable | 6d9kF-3b86A:9.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ch7 | 6-PHOSPHOGLUCONOLACTONASE (Leishmaniabraziliensis) |
PF01182(Glucosamine_iso) | 3 | TYR A 53ALA A 21LEU A 160 | None | 0.69A | 6d9kF-3ch7A:undetectable | 6d9kF-3ch7A:15.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3epd | PROTEIN VP2 (Enterovirus C) |
PF00073(Rhv) | 3 | TYR 2 192ALA 2 229LEU 2 180 | None | 0.61A | 6d9kF-3epd2:undetectable | 6d9kF-3epd2:16.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g8d | BIOTIN CARBOXYLASE (Escherichiacoli) |
PF00289(Biotin_carb_N)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 3 | TYR A 60ALA A 14LEU A 39 | None | 0.71A | 6d9kF-3g8dA:3.7 | 6d9kF-3g8dA:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hnr | PROBABLEMETHYLTRANSFERASEBT9727_4108 (Bacillusthuringiensis) |
PF08241(Methyltransf_11) | 3 | TYR A 27ALA A 161LEU A 173 | None | 0.73A | 6d9kF-3hnrA:2.3 | 6d9kF-3hnrA:13.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3id6 | PRE MRNA SPLICINGPROTEIN (Sulfolobussolfataricus) |
PF01798(Nop) | 3 | TYR A 114ALA A 101LEU A 97 | None | 0.73A | 6d9kF-3id6A:undetectable | 6d9kF-3id6A:16.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j2s | COAGULATION FACTORVIII LIGHT CHAIN (Homo sapiens) |
PF00754(F5_F8_type_C)PF07731(Cu-oxidase_2) | 3 | TYR B2105ALA B2328LEU B2302 | None | 0.77A | 6d9kF-3j2sB:undetectable | 6d9kF-3j2sB:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k5h | PHOSPHORIBOSYL-AMINOIMIDAZOLECARBOXYLASE (Aspergillusclavatus) |
PF01262(AlaDh_PNT_C)PF02222(ATP-grasp) | 3 | TYR A 141ALA A 180LEU A 132 | None | 0.52A | 6d9kF-3k5hA:3.2 | 6d9kF-3k5hA:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k6b | BETA-AMYLOID-LIKEPROTEIN (Caenorhabditiselegans) |
PF12925(APP_E2) | 3 | TYR A 343ALA A 431LEU A 417 | None | 0.75A | 6d9kF-3k6bA:undetectable | 6d9kF-3k6bA:14.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kfu | NON-DISCRIMINATINGAND ARCHAEAL-TYPEASPARTYL-TRNASYNTHETASE (Thermusthermophilus) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon) | 3 | TYR A 317ALA A 275LEU A 291 | None | 0.75A | 6d9kF-3kfuA:undetectable | 6d9kF-3kfuA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m6x | RRNA METHYLASE (Thermusthermophilus) |
PF01189(Methyltr_RsmB-F)PF17125(Methyltr_RsmF_N)PF17126(RsmF_methylt_CI) | 3 | TYR A 346ALA A 378LEU A 456 | None | 0.71A | 6d9kF-3m6xA:undetectable | 6d9kF-3m6xA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mca | PROTEIN DOM34 (Schizosaccharomycespombe) |
PF03463(eRF1_1)PF03464(eRF1_2)PF03465(eRF1_3) | 3 | TYR B 282ALA B 363LEU B 359 | None | 0.75A | 6d9kF-3mcaB:5.3 | 6d9kF-3mcaB:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mog | PROBABLE3-HYDROXYBUTYRYL-COADEHYDROGENASE (Escherichiacoli) |
PF00725(3HCDH)PF02737(3HCDH_N) | 3 | TYR A 34ALA A 92LEU A 102 | None | 0.56A | 6d9kF-3mogA:undetectable | 6d9kF-3mogA:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n0r | RESPONSE REGULATOR (Caulobactervibrioides) |
PF00072(Response_reg) | 3 | TYR A 17ALA A 93LEU A 65 | None | 0.66A | 6d9kF-3n0rA:2.3 | 6d9kF-3n0rA:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nra | ASPARTATEAMINOTRANSFERASE (Rhodobactersphaeroides) |
PF00155(Aminotran_1_2) | 3 | TYR A 195ALA A 191LEU A 154 | None | 0.74A | 6d9kF-3nraA:2.0 | 6d9kF-3nraA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p8a | UNCHARACTERIZEDPROTEIN (Staphylococcusaureus) |
PF13468(Glyoxalase_3) | 3 | TYR A 103ALA A 85LEU A 81 | None | 0.73A | 6d9kF-3p8aA:undetectable | 6d9kF-3p8aA:16.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ph9 | ANTERIOR GRADIENTPROTEIN 3 HOMOLOG (Homo sapiens) |
PF13899(Thioredoxin_7) | 3 | TYR A 48ALA A 55LEU A 126 | None | 0.69A | 6d9kF-3ph9A:undetectable | 6d9kF-3ph9A:11.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q2w | CADHERIN-2 (Mus musculus) |
PF00028(Cadherin) | 3 | TYR A 186ALA A 175LEU A 178 | None | 0.73A | 6d9kF-3q2wA:undetectable | 6d9kF-3q2wA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q5p | MULTIDRUG-EFFLUXTRANSPORTER 1REGULATOR (Bacillussubtilis) |
PF06445(GyrI-like)PF13411(MerR_1) | 3 | TYR A 84ALA A 72LEU A 59 | None | 0.76A | 6d9kF-3q5pA:undetectable | 6d9kF-3q5pA:18.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT N (Escherichiacoli) |
no annotation | 3 | TYR N 159ALA N 234LEU N 242 | None | 0.75A | 6d9kF-3rkoN:undetectable | 6d9kF-3rkoN:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3srz | TOXIN A (Clostridioidesdifficile) |
PF12918(TcdB_N)PF12919(TcdA_TcdB) | 3 | TYR A 23ALA A 70LEU A 9 | None | 0.61A | 6d9kF-3srzA:undetectable | 6d9kF-3srzA:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tix | UBIQUITIN-LIKEPROTEINSMT3,RNA-INDUCEDTRANSCRIPTIONALSILENCING COMPLEXPROTEIN TAS3CHROMODOMAIN-CONTAININGPROTEIN 1 (Schizosaccharomycespombe;Saccharomycescerevisiae;Schizosaccharomycespombe) |
PF11976(Rad60-SLD)no annotation | 3 | TYR B 803ALA A 65LEU A 48 | CL A1002 (-4.9A) CL A1002 ( 4.3A)None | 0.71A | 6d9kF-3tixB:2.3 | 6d9kF-3tixB:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u4a | JMB19063 (compostmetagenome) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 3 | TYR A 213ALA A 236LEU A 185 | None | 0.75A | 6d9kF-3u4aA:2.8 | 6d9kF-3u4aA:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3um6 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 3 | TYR A 205ALA A 13LEU A 174 | None | 0.74A | 6d9kF-3um6A:2.1 | 6d9kF-3um6A:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vqr | PUTATIVEOXIDOREDUCTASE (Aeropyrumpernix) |
PF01266(DAO) | 3 | TYR A 167ALA A 74LEU A 70 | None | 0.64A | 6d9kF-3vqrA:undetectable | 6d9kF-3vqrA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vzi | CRISPR-ASSOCIATEDPROTEIN CAS5, DVULGSUBTYPE (Xanthomonasoryzae) |
PF09704(Cas_Cas5d) | 3 | TYR A 114ALA A 35LEU A 154 | None | 0.75A | 6d9kF-3vziA:undetectable | 6d9kF-3vziA:16.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wvr | PGM1 (Streptomycescirratus) |
no annotation | 3 | TYR A 224ALA A 168LEU A 184 | None | 0.65A | 6d9kF-3wvrA:undetectable | 6d9kF-3wvrA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wxo | CATALASE-PEROXIDASE (Synechococcuselongatus) |
PF00141(peroxidase) | 3 | TYR A 575ALA A 707LEU A 600 | None | 0.66A | 6d9kF-3wxoA:undetectable | 6d9kF-3wxoA:23.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wye | DIACETYL REDUCTASE[(S)-ACETOINFORMING],L-2,3-BUTANEDIOLDEHYDROGENASE,DIACETYL REDUCTASE[(S)-ACETOINFORMING],L-2,3-BUTANEDIOLDEHYDROGENASE,DIACETYL REDUCTASE[(S)-ACETOINFORMING],L-2,3-BUTANEDIOLDEHYDROGENASE,DIACETYL REDUCTASE[(S)-ACETOINFORMING] (Klebsiellapneumoniae;Corynebacteriumglutamicum) |
PF13561(adh_short_C2) | 3 | TYR A 212ALA A 141LEU A 149 | None | 0.76A | 6d9kF-3wyeA:2.1 | 6d9kF-3wyeA:15.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b67 | L-ORNITHINE N5MONOOXYGENASE (Aspergillusfumigatus) |
PF13434(K_oxygenase) | 3 | TYR A 269ALA A 400LEU A 236 | None | 0.68A | 6d9kF-4b67A:undetectable | 6d9kF-4b67A:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bbm | CYCLIN-DEPENDENTKINASE-LIKE 2 (Homo sapiens) |
PF00069(Pkinase) | 3 | TYR A 253ALA A 264LEU A 201 | None | 0.70A | 6d9kF-4bbmA:undetectable | 6d9kF-4bbmA:19.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bhy | ALANINE RACEMASE (Aeromonashydrophila) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 3 | TYR A 277ALA A 281LEU A 296 | None | 0.60A | 6d9kF-4bhyA:undetectable | 6d9kF-4bhyA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cdb | LISTERIOLYSIN O (Listeriamonocytogenes) |
PF01289(Thiol_cytolysin)PF17440(Thiol_cytolys_C) | 3 | TYR A 387ALA A 291LEU A 137 | None | 0.73A | 6d9kF-4cdbA:2.0 | 6d9kF-4cdbA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cot | EXTRACELLULARENDO-ALPHA-(1->5)-L-ARABINANASE 2 (Bacillussubtilis) |
PF04616(Glyco_hydro_43)PF16369(GH43_C) | 3 | TYR A 243ALA A 257LEU A 216 | None | 0.76A | 6d9kF-4cotA:undetectable | 6d9kF-4cotA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d2i | HERA (Sulfolobussolfataricus) |
PF01935(DUF87)PF05872(DUF853)PF09378(HAS-barrel) | 3 | TYR A 115ALA A 106LEU A 39 | None | 0.76A | 6d9kF-4d2iA:undetectable | 6d9kF-4d2iA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f48 | PUTATIVEUNCHARACTERIZEDPROTEIN (Xanthomonascampestris) |
PF00563(EAL) | 3 | TYR A 39ALA A 241LEU A 246 | None | 0.65A | 6d9kF-4f48A:undetectable | 6d9kF-4f48A:18.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gbm | CURMSULFOTRANSFERASE (Mooreaproducens) |
PF13469(Sulfotransfer_3) | 3 | TYR A 164ALA A 300LEU A 292 | None | 0.66A | 6d9kF-4gbmA:3.7 | 6d9kF-4gbmA:17.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gox | POLYKETIDE SYNTHASE (Synechococcussp. PCC 7002) |
PF13469(Sulfotransfer_3) | 3 | TYR A 164ALA A 300LEU A 292 | None | 0.71A | 6d9kF-4goxA:4.5 | 6d9kF-4goxA:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4grc | PUTATIVE MEMBRANEPROTEIN (Streptomycescoelicolor) |
PF04261(Dyp_perox) | 3 | TYR A 116ALA A 110LEU A 131 | None | 0.75A | 6d9kF-4grcA:undetectable | 6d9kF-4grcA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hhr | ALPHA-DIOXYGENASE (Arabidopsisthaliana) |
PF03098(An_peroxidase) | 3 | TYR A 527ALA A 542LEU A 137 | None | 0.73A | 6d9kF-4hhrA:undetectable | 6d9kF-4hhrA:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hst | GLUTARYL-7-AMINOCEPHALOSPORANIC ACIDACYLASE ALPHA CHAINGLUTARYL-7-AMINOCEPHALOSPORANIC ACIDACYLASE BETA CHAIN (Pseudomonas;Pseudomonas) |
PF01804(Penicil_amidase)PF01804(Penicil_amidase) | 3 | TYR A 53ALA A 46LEU B 37 | None | 0.74A | 6d9kF-4hstA:undetectable | 6d9kF-4hstA:15.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hvt | POST-PROLINECLEAVING ENZYME (Rickettsiatyphi) |
PF00326(Peptidase_S9)PF02897(Peptidase_S9_N) | 3 | TYR A 699ALA A 587LEU A 481 | None | 0.76A | 6d9kF-4hvtA:3.7 | 6d9kF-4hvtA:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jhm | MANDELATE RACEMASE /MUCONATE LACTONIZINGENZYME, C-TERMINALDOMAIN PROTEIN (Pseudovibriosp. JE062) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | TYR A 301ALA A 333LEU A 14 | None | 0.72A | 6d9kF-4jhmA:undetectable | 6d9kF-4jhmA:19.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kdz | TRNA(CYTIDINE(34)-2'-O)-METHYLTRANSFERASE (Escherichiacoli) |
PF00588(SpoU_methylase) | 3 | TYR A 63ALA A 77LEU A 75 | None | 0.71A | 6d9kF-4kdzA:undetectable | 6d9kF-4kdzA:11.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kvl | FATTY ACIDALPHA-OXIDASE (Oryza sativa) |
PF03098(An_peroxidase) | 3 | TYR A 520ALA A 535LEU A 131 | None | 0.75A | 6d9kF-4kvlA:undetectable | 6d9kF-4kvlA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m00 | SERINE-RICH ADHESINFOR PLATELETS (Staphylococcusaureus) |
PF05345(He_PIG) | 3 | TYR A 446ALA A 391LEU A 318 | None | 0.68A | 6d9kF-4m00A:undetectable | 6d9kF-4m00A:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m01 | SERINE-RICH ADHESINFOR PLATELETS (Staphylococcusaureus) |
no annotation | 3 | TYR A 446ALA A 391LEU A 318 | None | 0.67A | 6d9kF-4m01A:undetectable | 6d9kF-4m01A:18.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mt0 | MTRE PROTEIN (Neisseriagonorrhoeae) |
PF02321(OEP) | 3 | TYR A 367ALA A 374LEU A 278 | None | 0.66A | 6d9kF-4mt0A:undetectable | 6d9kF-4mt0A:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mv3 | BIOTIN CARBOXYLASE (Haemophilusinfluenzae) |
PF00289(Biotin_carb_N)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 3 | TYR A 60ALA A 14LEU A 39 | None | 0.74A | 6d9kF-4mv3A:undetectable | 6d9kF-4mv3A:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nuq | CADHERIN-2 (Mus musculus) |
PF00028(Cadherin) | 3 | TYR A 186ALA A 175LEU A 178 | None | 0.76A | 6d9kF-4nuqA:undetectable | 6d9kF-4nuqA:15.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oua | LATENT FORM OF PPO4TYROSINASE (Agaricusbisporus) |
PF00264(Tyrosinase) | 3 | TYR B 506ALA B 417LEU B 520 | None | 0.69A | 6d9kF-4ouaB:undetectable | 6d9kF-4ouaB:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ow8 | SERINE/THREONINE-PROTEIN KINASE PKNA (Mycobacteriumtuberculosis) |
PF00069(Pkinase) | 3 | TYR A 261ALA A 273LEU A 248 | None | 0.76A | 6d9kF-4ow8A:undetectable | 6d9kF-4ow8A:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oya | ADENYLATE CYCLASETYPE 10 (Homo sapiens) |
PF00211(Guanylate_cyc) | 3 | TYR A 26ALA A 17LEU A 255 | NoneCME A 253 ( 4.4A)None | 0.75A | 6d9kF-4oyaA:undetectable | 6d9kF-4oyaA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p9a | POLYMERASE PA (Influenza Avirus) |
PF00603(Flu_PA) | 3 | TYR A 650ALA A 414LEU A 284 | None | 0.74A | 6d9kF-4p9aA:undetectable | 6d9kF-4p9aA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pb6 | VP1 (Felinecalicivirus) |
PF00915(Calici_coat) | 3 | TYR A 599ALA A 607LEU A 341 | None | 0.75A | 6d9kF-4pb6A:undetectable | 6d9kF-4pb6A:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q58 | PLECTIN (Homo sapiens) |
PF00307(CH) | 3 | TYR A 211ALA A 195LEU A 178 | None | 0.75A | 6d9kF-4q58A:undetectable | 6d9kF-4q58A:15.97 |