SIMILAR PATTERNS OF AMINO ACIDS FOR 6D9K_F_ACTF802

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bev BOVINE ENTEROVIRUS
COAT PROTEINS VP1 TO
VP4


(Enterovirus E)
PF00073
(Rhv)
3 TYR 2 170
ALA 2 207
LEU 2 158
None
0.68A 6d9kF-1bev2:
0.0
6d9kF-1bev2:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cmv HUMAN
CYTOMEGALOVIRUS
PROTEASE


(Human
betaherpesvirus
5)
PF00716
(Peptidase_S21)
3 TYR A 128
ALA A  67
LEU A 221
None
0.74A 6d9kF-1cmvA:
undetectable
6d9kF-1cmvA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)


(Clostridium
pasteurianum)
PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4)
3 TYR A 552
ALA A 331
LEU A 568
None
0.58A 6d9kF-1fehA:
2.9
6d9kF-1fehA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imv PIGMENT
EPITHELIUM-DERIVED
FACTOR


(Homo sapiens)
PF00079
(Serpin)
3 TYR A 102
ALA A 385
LEU A  63
None
0.71A 6d9kF-1imvA:
0.0
6d9kF-1imvA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l3w EP-CADHERIN

(Xenopus laevis)
PF00028
(Cadherin)
3 TYR A 259
ALA A 317
LEU A 242
None
0.68A 6d9kF-1l3wA:
undetectable
6d9kF-1l3wA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lkf LEUKOCIDIN F SUBUNIT

(Staphylococcus
aureus)
PF07968
(Leukocidin)
3 TYR A 245
ALA A  25
LEU A  36
None
0.75A 6d9kF-1lkfA:
undetectable
6d9kF-1lkfA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mke FUSION PROTEIN
CONSISTING OF
WISKOTT-ALDRICH
SYNDROME PROTEIN
INTERACTING PROTEIN
(WIP), GSGSG LINKER,
AND NEURAL
WISKOTT-ALDRICH
SYNDROME PROTEIN
(N-WASP)


(Homo sapiens;
Rattus
norvegicus)
PF00568
(WH1)
3 TYR A 102
ALA A 135
LEU A  69
None
0.76A 6d9kF-1mkeA:
undetectable
6d9kF-1mkeA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nw5 MODIFICATION
METHYLASE RSRI


(Rhodobacter
sphaeroides)
PF01555
(N6_N4_Mtase)
3 TYR A 299
ALA A 257
LEU A 284
None
0.73A 6d9kF-1nw5A:
2.2
6d9kF-1nw5A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT


(Acidaminococcus
fermentans)
PF01039
(Carboxyl_trans)
3 TYR A 320
ALA A 479
LEU A 451
None
0.52A 6d9kF-1pixA:
1.8
6d9kF-1pixA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxv CYSTEINE PROTEASE

(Staphylococcus
aureus)
PF05543
(Peptidase_C47)
3 TYR A 358
ALA A 326
LEU A 378
None
0.65A 6d9kF-1pxvA:
undetectable
6d9kF-1pxvA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus)
PF00028
(Cadherin)
3 TYR A 259
ALA A 317
LEU A 242
None
0.00A 6d9kF-1q5aA:
undetectable
6d9kF-1q5aA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwy PEPTIDOGLYCAN
HYDROLASE


(Staphylococcus
aureus)
PF01551
(Peptidase_M23)
3 TYR A 215
ALA A 189
LEU A 313
None
0.65A 6d9kF-1qwyA:
undetectable
6d9kF-1qwyA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpn GDP-MANNOSE
4,6-DEHYDRATASE


(Pseudomonas
aeruginosa)
PF16363
(GDP_Man_Dehyd)
3 TYR A  55
ALA A  19
LEU A  44
None
0.64A 6d9kF-1rpnA:
2.2
6d9kF-1rpnA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf0 SERUM ALBUMIN

(Homo sapiens)
PF00273
(Serum_albumin)
3 TYR A 138
ALA A 164
LEU A 182
None
0.75A 6d9kF-1tf0A:
undetectable
6d9kF-1tf0A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tue REPLICATION PROTEIN
E1


(Alphapapillomavirus
7)
PF00519
(PPV_E1_C)
3 TYR A 538
ALA A 546
LEU A 517
None
0.66A 6d9kF-1tueA:
undetectable
6d9kF-1tueA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2z HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC


(Saccharomyces
cerevisiae)
PF08123
(DOT1)
3 TYR A 435
ALA A 410
LEU A 449
None
0.68A 6d9kF-1u2zA:
undetectable
6d9kF-1u2zA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufa TT1467 PROTEIN

(Thermus
thermophilus)
PF03065
(Glyco_hydro_57)
PF09210
(DUF1957)
3 TYR A 515
ALA A 510
LEU A 454
None
0.76A 6d9kF-1ufaA:
undetectable
6d9kF-1ufaA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uiy ENOYL-COA HYDRATASE

(Thermus
thermophilus)
PF00378
(ECH_1)
3 TYR A 129
ALA A 148
LEU A 174
None
0.69A 6d9kF-1uiyA:
undetectable
6d9kF-1uiyA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcn CTP SYNTHETASE

(Thermus
thermophilus)
PF00117
(GATase)
PF06418
(CTP_synth_N)
3 TYR A 460
ALA A 492
LEU A 519
None
0.69A 6d9kF-1vcnA:
4.5
6d9kF-1vcnA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yk9 ADENYLATE CYCLASE

(Mycobacterium
tuberculosis)
PF00211
(Guanylate_cyc)
3 TYR A 280
ALA A 330
LEU A 343
None
0.73A 6d9kF-1yk9A:
undetectable
6d9kF-1yk9A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME B

(Rhodobacter
capsulatus)
PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
3 TYR C 403
ALA C 346
LEU C 116
None
0.76A 6d9kF-1zrtC:
undetectable
6d9kF-1zrtC:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aco OUTER MEMBRANE
LIPOPROTEIN BLC


(Escherichia
coli)
PF08212
(Lipocalin_2)
3 TYR A 116
ALA A  62
LEU A 141
None
0.70A 6d9kF-2acoA:
undetectable
6d9kF-2acoA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b44 GLYCYL-GLYCINE
ENDOPEPTIDASE LYTM


(Staphylococcus
aureus)
PF01551
(Peptidase_M23)
3 TYR A 215
ALA A 189
LEU A 313
None
0.66A 6d9kF-2b44A:
undetectable
6d9kF-2b44A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE


(Bacillus
subtilis)
PF01182
(Glucosamine_iso)
3 TYR A  44
ALA A  16
LEU A 130
None
0.73A 6d9kF-2bkxA:
undetectable
6d9kF-2bkxA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvm TOXIN B

(Clostridioides
difficile)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
3 TYR A  24
ALA A  71
LEU A   9
None
0.45A 6d9kF-2bvmA:
undetectable
6d9kF-2bvmA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida)
PF11647
(MLD)
3 TYR A 611
ALA A 656
LEU A 596
None
0.67A 6d9kF-2ec5A:
undetectable
6d9kF-2ec5A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzn MANNOSE-SPECIFIC
PHOSPHOTRANSFERASE
ENZYME IIA COMPONENT


(Escherichia
coli)
PF03610
(EIIA-man)
3 TYR A  87
ALA A   4
LEU A  53
None
0.57A 6d9kF-2jznA:
4.2
6d9kF-2jznA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k6v PUTATIVE CYTOCHROME
C OXIDASE ASSEMBLY
PROTEIN


(Thermus
thermophilus)
PF02630
(SCO1-SenC)
3 TYR A 153
ALA A  61
LEU A 168
None
0.56A 6d9kF-2k6vA:
undetectable
6d9kF-2k6vA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p22 SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE
PROTEIN SRN2


(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae)
PF09454
(Vps23_core)
PF07200
(Mod_r)
3 TYR C 213
ALA A 318
LEU C 150
None
0.71A 6d9kF-2p22C:
undetectable
6d9kF-2p22C:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfc PLCR PROTEIN

(Bacillus
thuringiensis)
PF01381
(HTH_3)
3 TYR A  64
ALA A  53
LEU A  49
None
0.64A 6d9kF-2qfcA:
undetectable
6d9kF-2qfcA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r66 GLYCOSYL
TRANSFERASE, GROUP 1


(Halothermothrix
orenii)
PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth)
3 TYR A 354
ALA A 264
LEU A 251
None
0.62A 6d9kF-2r66A:
2.5
6d9kF-2r66A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8w AGR_C_1641P

(Agrobacterium
fabrum)
PF00701
(DHDPS)
3 TYR A 222
ALA A 234
LEU A 207
None
0.76A 6d9kF-2r8wA:
undetectable
6d9kF-2r8wA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)


(Saccharomyces
cerevisiae)
PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT)
3 TYR G 890
ALA G 897
LEU G 864
None
0.66A 6d9kF-2uv8G:
undetectable
6d9kF-2uv8G:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdt LEVANSUCRASE

(Bacillus
subtilis)
PF02435
(Glyco_hydro_68)
3 TYR A 283
ALA A 306
LEU A 297
None
0.75A 6d9kF-2vdtA:
undetectable
6d9kF-2vdtA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl8 CYTOTOXIN L

(Paeniclostridium
sordellii)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
3 TYR A  24
ALA A  71
LEU A   9
None
0.50A 6d9kF-2vl8A:
undetectable
6d9kF-2vl8A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqd BIOTIN CARBOXYLASE

(Pseudomonas
aeruginosa)
PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
3 TYR A  60
ALA A  14
LEU A  39
None
0.74A 6d9kF-2vqdA:
4.3
6d9kF-2vqdA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww2 ALPHA-1,2-MANNOSIDAS
E


(Bacteroides
thetaiotaomicron)
PF07971
(Glyco_hydro_92)
3 TYR A  50
ALA A  54
LEU A 317
GOL  A 802 (-3.9A)
None
GOL  A 802 (-4.8A)
0.70A 6d9kF-2ww2A:
undetectable
6d9kF-2ww2A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0k PYROGLUTATMATE PORIN
OPDO


(Pseudomonas
aeruginosa)
PF03573
(OprD)
3 TYR A 201
ALA A 227
LEU A 116
None
0.68A 6d9kF-2y0kA:
undetectable
6d9kF-2y0kA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yx0 RADICAL SAM ENZYME

(Pyrococcus
horikoshii)
PF04055
(Radical_SAM)
PF08608
(Wyosine_form)
3 TYR A 125
ALA A 139
LEU A  44
None
0.72A 6d9kF-2yx0A:
undetectable
6d9kF-2yx0A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1q ACYL-COA
DEHYDROGENASE


(Thermus
thermophilus)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
3 TYR A 513
ALA A 319
LEU A 357
None
0.75A 6d9kF-2z1qA:
undetectable
6d9kF-2z1qA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3t CYTOCHROME P450

(Streptomyces
sp. TP-A0274)
PF00067
(p450)
3 TYR A  49
ALA A 303
LEU A  11
None
0.76A 6d9kF-2z3tA:
undetectable
6d9kF-2z3tA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc7 BETA-LACTAMASE ACT-1

(Klebsiella
pneumoniae)
PF00144
(Beta-lactamase)
3 TYR A 135
ALA A 114
LEU A 109
None
0.74A 6d9kF-2zc7A:
undetectable
6d9kF-2zc7A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj9 AMPC

(Escherichia
coli)
PF00144
(Beta-lactamase)
3 TYR A 135
ALA A 160
LEU A 216
None
0.73A 6d9kF-2zj9A:
undetectable
6d9kF-2zj9A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acp WD REPEAT-CONTAINING
PROTEIN YGL004C


(Saccharomyces
cerevisiae)
PF00400
(WD40)
3 TYR A 390
ALA A 344
LEU A 414
None
0.77A 6d9kF-3acpA:
undetectable
6d9kF-3acpA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b86 GENERAL
ODORANT-BINDING
PROTEIN LUSH


(Drosophila
melanogaster)
PF01395
(PBP_GOBP)
3 TYR A  47
ALA A 110
LEU A  31
None
0.74A 6d9kF-3b86A:
undetectable
6d9kF-3b86A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ch7 6-PHOSPHOGLUCONOLACT
ONASE


(Leishmania
braziliensis)
PF01182
(Glucosamine_iso)
3 TYR A  53
ALA A  21
LEU A 160
None
0.69A 6d9kF-3ch7A:
undetectable
6d9kF-3ch7A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epd PROTEIN VP2

(Enterovirus C)
PF00073
(Rhv)
3 TYR 2 192
ALA 2 229
LEU 2 180
None
0.61A 6d9kF-3epd2:
undetectable
6d9kF-3epd2:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8d BIOTIN CARBOXYLASE

(Escherichia
coli)
PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
3 TYR A  60
ALA A  14
LEU A  39
None
0.71A 6d9kF-3g8dA:
3.7
6d9kF-3g8dA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hnr PROBABLE
METHYLTRANSFERASE
BT9727_4108


(Bacillus
thuringiensis)
PF08241
(Methyltransf_11)
3 TYR A  27
ALA A 161
LEU A 173
None
0.73A 6d9kF-3hnrA:
2.3
6d9kF-3hnrA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3id6 PRE MRNA SPLICING
PROTEIN


(Sulfolobus
solfataricus)
PF01798
(Nop)
3 TYR A 114
ALA A 101
LEU A  97
None
0.73A 6d9kF-3id6A:
undetectable
6d9kF-3id6A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN


(Homo sapiens)
PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2)
3 TYR B2105
ALA B2328
LEU B2302
None
0.77A 6d9kF-3j2sB:
undetectable
6d9kF-3j2sB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5h PHOSPHORIBOSYL-AMINO
IMIDAZOLE
CARBOXYLASE


(Aspergillus
clavatus)
PF01262
(AlaDh_PNT_C)
PF02222
(ATP-grasp)
3 TYR A 141
ALA A 180
LEU A 132
None
0.52A 6d9kF-3k5hA:
3.2
6d9kF-3k5hA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6b BETA-AMYLOID-LIKE
PROTEIN


(Caenorhabditis
elegans)
PF12925
(APP_E2)
3 TYR A 343
ALA A 431
LEU A 417
None
0.75A 6d9kF-3k6bA:
undetectable
6d9kF-3k6bA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu NON-DISCRIMINATING
AND ARCHAEAL-TYPE
ASPARTYL-TRNA
SYNTHETASE


(Thermus
thermophilus)
PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
3 TYR A 317
ALA A 275
LEU A 291
None
0.75A 6d9kF-3kfuA:
undetectable
6d9kF-3kfuA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus)
PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI)
3 TYR A 346
ALA A 378
LEU A 456
None
0.71A 6d9kF-3m6xA:
undetectable
6d9kF-3m6xA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca PROTEIN DOM34

(Schizosaccharomyces
pombe)
PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3)
3 TYR B 282
ALA B 363
LEU B 359
None
0.75A 6d9kF-3mcaB:
5.3
6d9kF-3mcaB:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mog PROBABLE
3-HYDROXYBUTYRYL-COA
DEHYDROGENASE


(Escherichia
coli)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
3 TYR A  34
ALA A  92
LEU A 102
None
0.56A 6d9kF-3mogA:
undetectable
6d9kF-3mogA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0r RESPONSE REGULATOR

(Caulobacter
vibrioides)
PF00072
(Response_reg)
3 TYR A  17
ALA A  93
LEU A  65
None
0.66A 6d9kF-3n0rA:
2.3
6d9kF-3n0rA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nra ASPARTATE
AMINOTRANSFERASE


(Rhodobacter
sphaeroides)
PF00155
(Aminotran_1_2)
3 TYR A 195
ALA A 191
LEU A 154
None
0.74A 6d9kF-3nraA:
2.0
6d9kF-3nraA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8a UNCHARACTERIZED
PROTEIN


(Staphylococcus
aureus)
PF13468
(Glyoxalase_3)
3 TYR A 103
ALA A  85
LEU A  81
None
0.73A 6d9kF-3p8aA:
undetectable
6d9kF-3p8aA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ph9 ANTERIOR GRADIENT
PROTEIN 3 HOMOLOG


(Homo sapiens)
PF13899
(Thioredoxin_7)
3 TYR A  48
ALA A  55
LEU A 126
None
0.69A 6d9kF-3ph9A:
undetectable
6d9kF-3ph9A:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2w CADHERIN-2

(Mus musculus)
PF00028
(Cadherin)
3 TYR A 186
ALA A 175
LEU A 178
None
0.73A 6d9kF-3q2wA:
undetectable
6d9kF-3q2wA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5p MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR


(Bacillus
subtilis)
PF06445
(GyrI-like)
PF13411
(MerR_1)
3 TYR A  84
ALA A  72
LEU A  59
None
0.76A 6d9kF-3q5pA:
undetectable
6d9kF-3q5pA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N


(Escherichia
coli)
no annotation 3 TYR N 159
ALA N 234
LEU N 242
None
0.75A 6d9kF-3rkoN:
undetectable
6d9kF-3rkoN:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3srz TOXIN A

(Clostridioides
difficile)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
3 TYR A  23
ALA A  70
LEU A   9
None
0.61A 6d9kF-3srzA:
undetectable
6d9kF-3srzA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tix UBIQUITIN-LIKE
PROTEIN
SMT3,RNA-INDUCED
TRANSCRIPTIONAL
SILENCING COMPLEX
PROTEIN TAS3
CHROMO
DOMAIN-CONTAINING
PROTEIN 1


(Schizosaccharomyces
pombe;
Saccharomyces
cerevisiae;
Schizosaccharomyces
pombe)
PF11976
(Rad60-SLD)
no annotation
3 TYR B 803
ALA A  65
LEU A  48
CL  A1002 (-4.9A)
CL  A1002 ( 4.3A)
None
0.71A 6d9kF-3tixB:
2.3
6d9kF-3tixB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4a JMB19063

(compost
metagenome)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
3 TYR A 213
ALA A 236
LEU A 185
None
0.75A 6d9kF-3u4aA:
2.8
6d9kF-3u4aA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Plasmodium
falciparum)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
3 TYR A 205
ALA A  13
LEU A 174
None
0.74A 6d9kF-3um6A:
2.1
6d9kF-3um6A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vqr PUTATIVE
OXIDOREDUCTASE


(Aeropyrum
pernix)
PF01266
(DAO)
3 TYR A 167
ALA A  74
LEU A  70
None
0.64A 6d9kF-3vqrA:
undetectable
6d9kF-3vqrA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzi CRISPR-ASSOCIATED
PROTEIN CAS5, DVULG
SUBTYPE


(Xanthomonas
oryzae)
PF09704
(Cas_Cas5d)
3 TYR A 114
ALA A  35
LEU A 154
None
0.75A 6d9kF-3vziA:
undetectable
6d9kF-3vziA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvr PGM1

(Streptomyces
cirratus)
no annotation 3 TYR A 224
ALA A 168
LEU A 184
None
0.65A 6d9kF-3wvrA:
undetectable
6d9kF-3wvrA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxo CATALASE-PEROXIDASE

(Synechococcus
elongatus)
PF00141
(peroxidase)
3 TYR A 575
ALA A 707
LEU A 600
None
0.66A 6d9kF-3wxoA:
undetectable
6d9kF-3wxoA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wye DIACETYL REDUCTASE
[(S)-ACETOIN
FORMING],L-2,3-BUTAN
EDIOL
DEHYDROGENASE,DIACET
YL REDUCTASE
[(S)-ACETOIN
FORMING],L-2,3-BUTAN
EDIOL
DEHYDROGENASE,DIACET
YL REDUCTASE
[(S)-ACETOIN
FORMING],L-2,3-BUTAN
EDIOL
DEHYDROGENASE,DIACET
YL REDUCTASE
[(S)-ACETOIN
FORMING]


(Klebsiella
pneumoniae;
Corynebacterium
glutamicum)
PF13561
(adh_short_C2)
3 TYR A 212
ALA A 141
LEU A 149
None
0.76A 6d9kF-3wyeA:
2.1
6d9kF-3wyeA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b67 L-ORNITHINE N5
MONOOXYGENASE


(Aspergillus
fumigatus)
PF13434
(K_oxygenase)
3 TYR A 269
ALA A 400
LEU A 236
None
0.68A 6d9kF-4b67A:
undetectable
6d9kF-4b67A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bbm CYCLIN-DEPENDENT
KINASE-LIKE 2


(Homo sapiens)
PF00069
(Pkinase)
3 TYR A 253
ALA A 264
LEU A 201
None
0.70A 6d9kF-4bbmA:
undetectable
6d9kF-4bbmA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhy ALANINE RACEMASE

(Aeromonas
hydrophila)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
3 TYR A 277
ALA A 281
LEU A 296
None
0.60A 6d9kF-4bhyA:
undetectable
6d9kF-4bhyA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cdb LISTERIOLYSIN O

(Listeria
monocytogenes)
PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C)
3 TYR A 387
ALA A 291
LEU A 137
None
0.73A 6d9kF-4cdbA:
2.0
6d9kF-4cdbA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2


(Bacillus
subtilis)
PF04616
(Glyco_hydro_43)
PF16369
(GH43_C)
3 TYR A 243
ALA A 257
LEU A 216
None
0.76A 6d9kF-4cotA:
undetectable
6d9kF-4cotA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2i HERA

(Sulfolobus
solfataricus)
PF01935
(DUF87)
PF05872
(DUF853)
PF09378
(HAS-barrel)
3 TYR A 115
ALA A 106
LEU A  39
None
0.76A 6d9kF-4d2iA:
undetectable
6d9kF-4d2iA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f48 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Xanthomonas
campestris)
PF00563
(EAL)
3 TYR A  39
ALA A 241
LEU A 246
None
0.65A 6d9kF-4f48A:
undetectable
6d9kF-4f48A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbm CURM
SULFOTRANSFERASE


(Moorea
producens)
PF13469
(Sulfotransfer_3)
3 TYR A 164
ALA A 300
LEU A 292
None
0.66A 6d9kF-4gbmA:
3.7
6d9kF-4gbmA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gox POLYKETIDE SYNTHASE

(Synechococcus
sp. PCC 7002)
PF13469
(Sulfotransfer_3)
3 TYR A 164
ALA A 300
LEU A 292
None
0.71A 6d9kF-4goxA:
4.5
6d9kF-4goxA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grc PUTATIVE MEMBRANE
PROTEIN


(Streptomyces
coelicolor)
PF04261
(Dyp_perox)
3 TYR A 116
ALA A 110
LEU A 131
None
0.75A 6d9kF-4grcA:
undetectable
6d9kF-4grcA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhr ALPHA-DIOXYGENASE

(Arabidopsis
thaliana)
PF03098
(An_peroxidase)
3 TYR A 527
ALA A 542
LEU A 137
None
0.73A 6d9kF-4hhrA:
undetectable
6d9kF-4hhrA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN
GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN


(Pseudomonas;
Pseudomonas)
PF01804
(Penicil_amidase)
PF01804
(Penicil_amidase)
3 TYR A  53
ALA A  46
LEU B  37
None
0.74A 6d9kF-4hstA:
undetectable
6d9kF-4hstA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvt POST-PROLINE
CLEAVING ENZYME


(Rickettsia
typhi)
PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N)
3 TYR A 699
ALA A 587
LEU A 481
None
0.76A 6d9kF-4hvtA:
3.7
6d9kF-4hvtA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhm MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME, C-TERMINAL
DOMAIN PROTEIN


(Pseudovibrio
sp. JE062)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 TYR A 301
ALA A 333
LEU A  14
None
0.72A 6d9kF-4jhmA:
undetectable
6d9kF-4jhmA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kdz TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE


(Escherichia
coli)
PF00588
(SpoU_methylase)
3 TYR A  63
ALA A  77
LEU A  75
None
0.71A 6d9kF-4kdzA:
undetectable
6d9kF-4kdzA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvl FATTY ACID
ALPHA-OXIDASE


(Oryza sativa)
PF03098
(An_peroxidase)
3 TYR A 520
ALA A 535
LEU A 131
None
0.75A 6d9kF-4kvlA:
undetectable
6d9kF-4kvlA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m00 SERINE-RICH ADHESIN
FOR PLATELETS


(Staphylococcus
aureus)
PF05345
(He_PIG)
3 TYR A 446
ALA A 391
LEU A 318
None
0.68A 6d9kF-4m00A:
undetectable
6d9kF-4m00A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m01 SERINE-RICH ADHESIN
FOR PLATELETS


(Staphylococcus
aureus)
no annotation 3 TYR A 446
ALA A 391
LEU A 318
None
0.67A 6d9kF-4m01A:
undetectable
6d9kF-4m01A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt0 MTRE PROTEIN

(Neisseria
gonorrhoeae)
PF02321
(OEP)
3 TYR A 367
ALA A 374
LEU A 278
None
0.66A 6d9kF-4mt0A:
undetectable
6d9kF-4mt0A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mv3 BIOTIN CARBOXYLASE

(Haemophilus
influenzae)
PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
3 TYR A  60
ALA A  14
LEU A  39
None
0.74A 6d9kF-4mv3A:
undetectable
6d9kF-4mv3A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuq CADHERIN-2

(Mus musculus)
PF00028
(Cadherin)
3 TYR A 186
ALA A 175
LEU A 178
None
0.76A 6d9kF-4nuqA:
undetectable
6d9kF-4nuqA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua LATENT FORM OF PPO4
TYROSINASE


(Agaricus
bisporus)
PF00264
(Tyrosinase)
3 TYR B 506
ALA B 417
LEU B 520
None
0.69A 6d9kF-4ouaB:
undetectable
6d9kF-4ouaB:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA


(Mycobacterium
tuberculosis)
PF00069
(Pkinase)
3 TYR A 261
ALA A 273
LEU A 248
None
0.76A 6d9kF-4ow8A:
undetectable
6d9kF-4ow8A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oya ADENYLATE CYCLASE
TYPE 10


(Homo sapiens)
PF00211
(Guanylate_cyc)
3 TYR A  26
ALA A  17
LEU A 255
None
CME  A 253 ( 4.4A)
None
0.75A 6d9kF-4oyaA:
undetectable
6d9kF-4oyaA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9a POLYMERASE PA

(Influenza A
virus)
PF00603
(Flu_PA)
3 TYR A 650
ALA A 414
LEU A 284
None
0.74A 6d9kF-4p9aA:
undetectable
6d9kF-4p9aA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pb6 VP1

(Feline
calicivirus)
PF00915
(Calici_coat)
3 TYR A 599
ALA A 607
LEU A 341
None
0.75A 6d9kF-4pb6A:
undetectable
6d9kF-4pb6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q58 PLECTIN

(Homo sapiens)
PF00307
(CH)
3 TYR A 211
ALA A 195
LEU A 178
None
0.75A 6d9kF-4q58A:
undetectable
6d9kF-4q58A:
15.97