SIMILAR PATTERNS OF AMINO ACIDS FOR 6D8P_B_ACTB804

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1avo 11S REGULATOR
11S REGULATOR

(Homo sapiens;
Homo sapiens) 		PF02251
(PA28_alpha)
PF02252
(PA28_beta) 		4 HIS B 202
VAL B 104
LEU A  61
ALA A  59
 None
 1.35A 6d8pB-1avoB:
undetectable		 6d8pB-1avoB:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bud PROTEIN (ACUTOLYSIN
A)

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		4 HIS A  92
VAL A  13
LEU A  86
ALA A  95
 None
 1.44A 6d8pB-1budA:
0.2		 6d8pB-1budA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3l SUBTILISIN-CARLSBERG

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		4 HIS A 238
VAL A 246
LEU A 241
ALA A 274
 None
 1.26A 6d8pB-1c3lA:
3.0		 6d8pB-1c3lA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htd ATROLYSIN C

(Crotalus atrox) 		PF01421
(Reprolysin) 		4 HIS A  92
VAL A  13
LEU A  86
ALA A  95
 None
 1.41A 6d8pB-1htdA:
0.0		 6d8pB-1htdA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idm 3-ISOPROPYLMALATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		4 HIS A 298
VAL A 129
LEU A 101
ALA A 170
 None
 1.37A 6d8pB-1idmA:
2.9		 6d8pB-1idmA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkm BREFELDIN A ESTERASE

(Bacillus
subtilis) 		PF07859
(Abhydrolase_3) 		4 HIS A 167
VAL A  60
LEU A  57
ALA A 271
 None
 0.96A 6d8pB-1jkmA:
2.6		 6d8pB-1jkmA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkm BREFELDIN A ESTERASE

(Bacillus
subtilis) 		PF07859
(Abhydrolase_3) 		4 HIS A 167
VAL A  64
LEU A  61
ALA A 161
 None
 1.27A 6d8pB-1jkmA:
2.6		 6d8pB-1jkmA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kug METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		4 HIS A  94
VAL A  15
LEU A  88
ALA A  97
 None
 1.38A 6d8pB-1kugA:
0.0		 6d8pB-1kugA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvl DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 HIS A 230
VAL A 175
LEU A 255
ALA A 228
 None
 1.35A 6d8pB-1lvlA:
undetectable		 6d8pB-1lvlA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1c MAJOR COAT PROTEIN

(Saccharomyces
cerevisiae
virus L-A) 		PF09220
(LA-virus_coat) 		4 HIS A 316
VAL A 464
LEU A 433
ALA A 312
 None
 1.42A 6d8pB-1m1cA:
undetectable		 6d8pB-1m1cA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd1 BAP1

(Bothrops asper) 		PF01421
(Reprolysin) 		4 HIS A  92
VAL A  13
LEU A  86
ALA A  95
 None
 1.38A 6d8pB-1nd1A:
5.5		 6d8pB-1nd1A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1now BETA-HEXOSAMINIDASE
BETA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 HIS A  81
VAL A 165
LEU A  94
ALA A  87
 None
 1.42A 6d8pB-1nowA:
2.6		 6d8pB-1nowA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyw ATP-DEPENDENT DNA
HELICASE

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		4 HIS A 267
VAL A 278
LEU A 270
ALA A 265
 None
 1.02A 6d8pB-1oywA:
2.7		 6d8pB-1oywA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Homo sapiens) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 HIS A  73
VAL A  99
LEU A 131
ALA A 134
 None
 1.43A 6d8pB-1pl0A:
4.2		 6d8pB-1pl0A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl8 HUMAN SORBITOL
DEHYDROGENASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 HIS A  84
VAL A  34
LEU A  85
ALA A 137
 None
 1.08A 6d8pB-1pl8A:
3.6		 6d8pB-1pl8A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl8 HUMAN SORBITOL
DEHYDROGENASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 HIS A  84
VAL A  75
LEU A  85
ALA A 136
 None
 1.35A 6d8pB-1pl8A:
3.6		 6d8pB-1pl8A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tw9 GLUTATHIONE
S-TRANSFERASE 2

(Heligmosomoides
polygyrus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 HIS A 184
VAL A 156
LEU A 148
ALA A 161
 None
 1.34A 6d8pB-1tw9A:
undetectable		 6d8pB-1tw9A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufo HYPOTHETICAL PROTEIN
TT1662

(Thermus
thermophilus) 		no annotation 4 HIS A 177
VAL A 132
LEU A 175
ALA A 134
 None
 1.45A 6d8pB-1ufoA:
3.7		 6d8pB-1ufoA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vz8 ORNITHINE
ACETYL-TRANSFERASE

(Streptomyces
clavuligerus) 		PF01960
(ArgJ) 		4 HIS A 126
VAL A  31
LEU A 130
ALA A  17
 None
 1.45A 6d8pB-1vz8A:
undetectable		 6d8pB-1vz8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS

(Escherichia
coli) 		PF01168
(Ala_racemase_N) 		4 HIS A  68
VAL A  74
LEU A  72
ALA A  44
 None
 1.30A 6d8pB-1w8gA:
undetectable		 6d8pB-1w8gA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN

(Pyrococcus
horikoshii) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		4 HIS A 277
VAL A 272
LEU A 274
ALA A 268
 None
 1.24A 6d8pB-1wu2A:
3.3		 6d8pB-1wu2A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE

(Salmonella
enterica) 		PF04223
(CitF) 		4 HIS A 393
VAL A 363
LEU A 365
ALA A 397
 None
 1.29A 6d8pB-1xr4A:
undetectable		 6d8pB-1xr4A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Entamoeba
histolytica) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 HIS A 188
VAL A 152
LEU A 314
ALA A 184
 None
 1.39A 6d8pB-1y9aA:
undetectable		 6d8pB-1y9aA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeu HYPOTHETICAL PROTEIN
MJ0158

(Methanocaldococcus
jannaschii) 		PF03841
(SelA) 		4 HIS A  70
VAL A 202
LEU A  71
ALA A 183
 None
 1.19A 6d8pB-2aeuA:
2.8		 6d8pB-2aeuA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF01156
(IU_nuc_hydro) 		4 HIS A   8
VAL A  84
LEU A  15
ALA A  44
 None
 1.19A 6d8pB-2c40A:
undetectable		 6d8pB-2c40A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw1 CATROCOLLASTATIN

(Crotalus atrox) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		4 HIS A 284
VAL A 205
LEU A 278
ALA A 287
 None
 1.40A 6d8pB-2dw1A:
4.3		 6d8pB-2dw1A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		4 HIS A 210
VAL A 134
LEU A 185
ALA A 212
 None
 1.42A 6d8pB-2eb5A:
undetectable		 6d8pB-2eb5A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		4 HIS A 218
VAL A  41
LEU A 219
ALA A 168
 EDO  A 622 ( 3.6A)
FAD  A 611 (-4.9A)
FAD  A 611 (-4.4A)
EDO  A 622 (-3.4A)
 1.28A 6d8pB-2gmhA:
undetectable		 6d8pB-2gmhA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isn NYSGXRC-8828Z,
PHOSPHATASE

(Toxoplasma
gondii) 		PF00481
(PP2C) 		4 HIS A  52
VAL A 255
LEU A 231
ALA A 236
 None
 1.39A 6d8pB-2isnA:
undetectable		 6d8pB-2isnA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Gallus gallus) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 HIS A  74
VAL A 100
LEU A 132
ALA A 135
 None
 1.44A 6d8pB-2iu3A:
3.2		 6d8pB-2iu3A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kxv TELLURITE RESISTANCE
PROTEIN

(Klebsiella
pneumoniae) 		PF02342
(TerD) 		4 HIS A  57
VAL A   7
LEU A  73
ALA A  25
 None
 1.33A 6d8pB-2kxvA:
undetectable		 6d8pB-2kxvA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2naf PEPTIDYL-TRNA
HYDROLASE

(Mycolicibacterium
smegmatis) 		PF01195
(Pept_tRNA_hydro) 		4 HIS A 131
VAL A 188
LEU A 106
ALA A 184
 None
 1.23A 6d8pB-2nafA:
4.1		 6d8pB-2nafA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz2 ARGININOSUCCINATE
SYNTHASE

(Homo sapiens) 		PF00764
(Arginosuc_synth) 		4 HIS A 327
VAL A 103
LEU A 135
ALA A  99
 None
 1.29A 6d8pB-2nz2A:
4.9		 6d8pB-2nz2A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvp D-ALANINE-D-ALANINE
LIGASE

(Helicobacter
pylori) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 HIS A  42
VAL A  95
LEU A  38
ALA A  10
 None
 1.31A 6d8pB-2pvpA:
3.1		 6d8pB-2pvpA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		4 HIS A 872
VAL A 890
LEU A 868
ALA A 894
 None
 1.41A 6d8pB-2r6fA:
undetectable		 6d8pB-2r6fA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uwf ALKALINE ACTIVE
ENDOXYLANASE

(Bacillus
halodurans) 		PF00331
(Glyco_hydro_10) 		4 HIS A  51
VAL A 344
LEU A  21
ALA A  15
 None
 1.35A 6d8pB-2uwfA:
undetectable		 6d8pB-2uwfA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vea PHYTOCHROME-LIKE
PROTEIN CPH1

(Synechocystis
sp. PCC 6803) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		4 HIS A 260
VAL A 227
LEU A 264
ALA A 256
 CYC  A1521 (-3.4A)
None
None
CYC  A1521 (-3.9A)
 1.29A 6d8pB-2veaA:
undetectable		 6d8pB-2veaA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 HIS A 510
VAL A 460
LEU A 426
ALA A 384
 None
 1.27A 6d8pB-2x3kA:
undetectable		 6d8pB-2x3kA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro)
PF08369
(PCP_red) 		4 HIS D  13
VAL D  55
LEU D  30
ALA D  39
 None
 1.06A 6d8pB-2ynmD:
3.2		 6d8pB-2ynmD:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3btp SINGLE-STRAND
DNA-BINDING PROTEIN

(Agrobacterium
fabrum) 		PF07229
(VirE2) 		4 HIS A 419
VAL A 398
LEU A 423
ALA A 400
 None
 1.23A 6d8pB-3btpA:
undetectable		 6d8pB-3btpA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00389
(2-Hacid_dh)
PF01842
(ACT)
PF02826
(2-Hacid_dh_C) 		4 HIS A 106
VAL A 229
LEU A 110
ALA A 231
 None
 1.25A 6d8pB-3ddnA:
3.9		 6d8pB-3ddnA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dms ISOCITRATE
DEHYDROGENASE [NADP]

(Burkholderia
pseudomallei) 		PF00180
(Iso_dh) 		4 HIS A 368
VAL A  98
LEU A  23
ALA A 335
 None
 1.21A 6d8pB-3dmsA:
4.7		 6d8pB-3dmsA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsl ZINC
METALLOPROTEINASE-DI
SINTEGRIN
BOTHROPASIN

(Bothrops
jararaca) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		4 HIS A  95
VAL A  16
LEU A  89
ALA A  98
 None
 1.44A 6d8pB-3dslA:
4.6		 6d8pB-3dslA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		4 HIS A 268
VAL A 220
LEU A 370
ALA A 265
 None
 1.24A 6d8pB-3du4A:
undetectable		 6d8pB-3du4A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ear HERA

(Thermus
thermophilus) 		PF00271
(Helicase_C) 		4 HIS A 269
VAL A 280
LEU A 272
ALA A 267
 None
 0.93A 6d8pB-3earA:
undetectable		 6d8pB-3earA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejg NON-STRUCTURAL
PROTEIN 3

(Human
coronavirus
229E) 		PF01661
(Macro) 		4 HIS A  41
VAL A  71
LEU A  39
ALA A  35
 None
 1.44A 6d8pB-3ejgA:
3.6		 6d8pB-3ejgA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3exs RMPD
(HEXULOSE-6-PHOSPHAT
E SYNTHASE)

(Streptococcus
mutans) 		PF00215
(OMPdecase) 		4 HIS A  14
VAL A  10
LEU A  12
ALA A  23
 None
 1.40A 6d8pB-3exsA:
undetectable		 6d8pB-3exsA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ile PUTATIVE
UNCHARACTERIZED
PROTEIN

(Acidianus
filamentous
virus 1) 		PF11646
(DUF3258) 		4 HIS A  22
VAL A 128
LEU A  24
ALA A 126
 None
 1.35A 6d8pB-3ileA:
undetectable		 6d8pB-3ileA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3km2 SUPEROXIDE DISMUTASE
[CU-ZN],
CHLOROPLASTIC

(Solanum
lycopersicum) 		PF00080
(Sod_Cu) 		4 HIS A  43
VAL A  15
LEU A 144
ALA A  39
 None
 1.44A 6d8pB-3km2A:
undetectable		 6d8pB-3km2A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2t PROBABLE
DEHYDROGENASE

(Chromobacterium
violaceum) 		PF01408
(GFO_IDH_MocA) 		4 HIS A  79
VAL A   9
LEU A  78
ALA A  73
 NAD  A 358 (-4.4A)
None
NAD  A 358 (-4.1A)
NAD  A 358 (-4.0A)
 1.37A 6d8pB-3m2tA:
2.7		 6d8pB-3m2tA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgx PUTATIVE P450
MONOOXYGENASE

(Amycolatopsis
balhimycina) 		PF00067
(p450) 		4 HIS A 249
VAL A 391
LEU A 389
ALA A 252
 GOL  A 401 (-4.3A)
None
None
None
 1.41A 6d8pB-3mgxA:
undetectable		 6d8pB-3mgxA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx3 ACETYLORNITHINE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00202
(Aminotran_3) 		4 HIS A 236
VAL A 188
LEU A 332
ALA A 233
 None
 1.34A 6d8pB-3nx3A:
undetectable		 6d8pB-3nx3A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odm PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Clostridium
perfringens) 		PF14010
(PEPcase_2) 		4 HIS A 491
VAL A 451
LEU A 494
ALA A 447
 None
 1.32A 6d8pB-3odmA:
3.9		 6d8pB-3odmA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of7 REGULATOR OF
CHROMOSOME
CONDENSATION

(Saccharomyces
cerevisiae) 		PF00415
(RCC1)
PF13540
(RCC1_2) 		4 HIS A 341
VAL A 399
LEU A 343
ALA A 401
 None
 1.39A 6d8pB-3of7A:
undetectable		 6d8pB-3of7A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ow2 50S RIBOSOMAL
PROTEIN L2P

(Haloarcula
marismortui) 		PF00181
(Ribosomal_L2)
PF03947
(Ribosomal_L2_C) 		4 HIS A 131
VAL A 138
LEU A 128
ALA A 136
 None
 1.35A 6d8pB-3ow2A:
undetectable		 6d8pB-3ow2A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		4 HIS A 296
VAL A 171
LEU A 173
ALA A 262
 None
 1.22A 6d8pB-3p27A:
3.0		 6d8pB-3p27A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pe0 PLECTIN

(Homo sapiens) 		PF00435
(Spectrin) 		4 HIS A 807
VAL A 896
LEU A 811
ALA A 761
 None
 1.17A 6d8pB-3pe0A:
undetectable		 6d8pB-3pe0A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qe3 SORBITOL
DEHYDROGENASE

(Ovis aries) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 HIS A  83
VAL A  74
LEU A  84
ALA A 135
 None
 1.28A 6d8pB-3qe3A:
3.0		 6d8pB-3qe3A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qha PUTATIVE
OXIDOREDUCTASE

(Mycobacterium
avium) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 HIS A  71
VAL A  96
LEU A  69
ALA A  98
 None
 1.20A 6d8pB-3qhaA:
2.2		 6d8pB-3qhaA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umv DEOXYRIBODIPYRIMIDIN
E PHOTO-LYASE

(Oryza sativa) 		PF00875
(DNA_photolyase) 		4 HIS A 164
VAL A  40
LEU A  62
ALA A 162
 None
 1.24A 6d8pB-3umvA:
2.1		 6d8pB-3umvA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux8 EXCINUCLEASE ABC, A
SUBUNIT

(Geobacillus sp.
Y412MC52) 		PF00005
(ABC_tran) 		4 HIS A 872
VAL A 890
LEU A 868
ALA A 894
 None
 1.43A 6d8pB-3ux8A:
undetectable		 6d8pB-3ux8A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm7 ALPHA-AMYLASE

(Malbranchea
cinnamomea) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		4 HIS A 380
VAL A 477
LEU A 453
ALA A 335
 None
 1.15A 6d8pB-3vm7A:
undetectable		 6d8pB-3vm7A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ar9 COLLAGENASE COLT

(Clostridium
tetani) 		PF01752
(Peptidase_M9) 		4 HIS A 601
VAL A 520
LEU A 605
ALA A 553
 None
 1.41A 6d8pB-4ar9A:
3.1		 6d8pB-4ar9A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arc LEUCINE--TRNA LIGASE

(Escherichia
coli) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		4 HIS A 265
VAL A 320
LEU A 267
ALA A 334
 None
 1.27A 6d8pB-4arcA:
undetectable		 6d8pB-4arcA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 3

(Mus musculus) 		PF07528
(DZF) 		4 HIS B 305
VAL B 284
LEU B 306
ALA B 302
 None
 1.28A 6d8pB-4atbB:
undetectable		 6d8pB-4atbB:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT

(Moorella
thermoacetica) 		PF03599
(CdhD) 		4 HIS D 181
VAL D 134
LEU D 159
ALA D 151
 None
 1.25A 6d8pB-4djeD:
2.3		 6d8pB-4djeD:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyo ASPARTYL
AMINOPEPTIDASE

(Homo sapiens) 		PF02127
(Peptidase_M18) 		4 HIS A 359
VAL A 372
LEU A 405
ALA A 350
 None
 0.89A 6d8pB-4dyoA:
2.3		 6d8pB-4dyoA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f67 UPF0176 PROTEIN
LPG2838

(Legionella
pneumophila) 		PF00581
(Rhodanese) 		4 HIS A  30
VAL A  89
LEU A  26
ALA A  87
 None
 1.22A 6d8pB-4f67A:
3.3		 6d8pB-4f67A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1j SORTASE FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF04203
(Sortase) 		4 HIS A 143
VAL A 151
LEU A 149
ALA A 158
 None
 1.42A 6d8pB-4g1jA:
undetectable		 6d8pB-4g1jA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzc CYSE, SERINE
ACETYLTRANSFERASE

(Brucella
abortus) 		PF00132
(Hexapep)
PF06426
(SATase_N) 		4 HIS A 124
VAL A 180
LEU A 160
ALA A 158
 None
 1.33A 6d8pB-4hzcA:
undetectable		 6d8pB-4hzcA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbf HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 HIS A 269
VAL A 280
LEU A 272
ALA A 267
 None
 0.90A 6d8pB-4kbfA:
2.1		 6d8pB-4kbfA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mxm TRANSCRIPTIONAL
REGULATOR I2

(Pseudomonas
fluorescens) 		PF00440
(TetR_N) 		4 HIS A  55
VAL A  45
LEU A  20
ALA A  16
 None
 1.32A 6d8pB-4mxmA:
undetectable		 6d8pB-4mxmA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5c CARGO-TRANSPORT
PROTEIN YPP1

(Saccharomyces
cerevisiae) 		no annotation 4 HIS A 530
VAL A 552
LEU A 576
ALA A 533
 None
 1.22A 6d8pB-4n5cA:
undetectable		 6d8pB-4n5cA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o3m BLOOM SYNDROME
PROTEIN

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF00570
(HRDC)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		4 HIS A 919
VAL A 930
LEU A 922
ALA A 917
 None
 0.97A 6d8pB-4o3mA:
3.0		 6d8pB-4o3mA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p08 COCAINE ESTERASE

(Rhodococcus sp.
MB1) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 HIS A 314
VAL A 281
LEU A 252
ALA A 310
 None
 1.27A 6d8pB-4p08A:
4.9		 6d8pB-4p08A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1l SNAKE VENOM
METALLOPROTEINASE
LEUCUROLYSIN-A

(Bothrops
leucurus) 		PF01421
(Reprolysin) 		4 HIS A  92
VAL A  13
LEU A  86
ALA A  95
 None
 1.44A 6d8pB-4q1lA:
4.7		 6d8pB-4q1lA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvs PROBABLE QUINONE
REDUCTASE QOR
(NADPH:QUINONE
REDUCTASE)
(ZETA-CRYSTALLIN
HOMOLOG PROTEIN)

(Mycobacterium
tuberculosis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 HIS A 149
VAL A 205
LEU A 147
ALA A 228
 None
 0.88A 6d8pB-4rvsA:
2.5		 6d8pB-4rvsA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmu RECQ

(Cronobacter
sakazakii) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		4 HIS A 267
VAL A 274
LEU A 270
ALA A 265
 None
 1.31A 6d8pB-4tmuA:
3.9		 6d8pB-4tmuA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trt DNA POLYMERASE III
SUBUNIT BETA

(Deinococcus
radiodurans) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 HIS A 160
VAL A 167
LEU A 158
ALA A 165
 None
 1.33A 6d8pB-4trtA:
undetectable		 6d8pB-4trtA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvm STONUSTOXIN SUBUNIT
BETA

(Synanceia
horrida) 		PF00622
(SPRY)
PF13765
(PRY) 		4 HIS B 140
VAL B   8
LEU B   6
ALA B  23
 None
 1.28A 6d8pB-4wvmB:
undetectable		 6d8pB-4wvmB:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj5 CYCLIC AMP-GMP
SYNTHASE

(Vibrio cholerae) 		no annotation 4 HIS A 317
VAL A 282
LEU A 312
ALA A 319
 EDO  A1012 (-4.0A)
None
None
EDO  A1012 (-3.3A)
 1.30A 6d8pB-4xj5A:
undetectable		 6d8pB-4xj5A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST

(Pseudomonas
aeruginosa) 		no annotation 4 HIS A 830
VAL A 818
LEU A 782
ALA A 824
 None
 1.44A 6d8pB-5b7iA:
2.5		 6d8pB-5b7iA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5u PROLYL 4-HYDROXYLASE

(Paramecium
bursaria
Chlorella virus
1) 		PF13640
(2OG-FeII_Oxy_3) 		4 HIS A 109
VAL A 140
LEU A  67
ALA A  70
 None
 1.43A 6d8pB-5c5uA:
undetectable		 6d8pB-5c5uA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6g AGR133CP
SISTER CHROMATID
COHESION PROTEIN 2

(Eremothecium
gossypii;
Eremothecium
gossypii) 		PF10345
(Cohesin_load)
no annotation 		4 HIS B  21
VAL A 442
LEU A 439
ALA A 437
 None
 1.39A 6d8pB-5c6gB:
undetectable		 6d8pB-5c6gB:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eso 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Mycobacterium
tuberculosis) 		PF02776
(TPP_enzyme_N) 		4 HIS A 281
VAL A 380
LEU A 280
ALA A 384
 None
 1.24A 6d8pB-5esoA:
undetectable		 6d8pB-5esoA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		4 HIS A 118
VAL A  85
LEU A  83
ALA A 126
 None
 1.40A 6d8pB-5hpjA:
undetectable		 6d8pB-5hpjA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1f PLECTIN,PLECTIN

(Homo sapiens) 		no annotation 4 HIS A 807
VAL A 896
LEU A 811
ALA A 761
 None
 1.23A 6d8pB-5j1fA:
2.1		 6d8pB-5j1fA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lb3 ATP-DEPENDENT DNA
HELICASE Q5

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16124
(RecQ_Zn_bind) 		4 HIS B 290
VAL B 301
LEU B 293
ALA B 288
 None
 1.09A 6d8pB-5lb3B:
2.8		 6d8pB-5lb3B:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lb8 ATP-DEPENDENT DNA
HELICASE Q5

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16124
(RecQ_Zn_bind) 		4 HIS A 290
VAL A 301
LEU A 293
ALA A 288
 None
 0.82A 6d8pB-5lb8A:
2.4		 6d8pB-5lb8A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mx5 PROTEASOME ACTIVATOR
COMPLEX SUBUNIT 1

(Mus musculus) 		PF02251
(PA28_alpha)
PF02252
(PA28_beta) 		4 HIS A 202
VAL A 104
LEU A  61
ALA A  59
 None
 1.39A 6d8pB-5mx5A:
undetectable		 6d8pB-5mx5A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE

(Brucella suis) 		PF00106
(adh_short) 		4 HIS A  50
VAL A  83
LEU A  79
ALA A  77
 NAP  A 301 (-4.5A)
EDO  A 302 ( 4.8A)
NAP  A 301 ( 3.7A)
None
 1.43A 6d8pB-5tgdA:
2.0		 6d8pB-5tgdA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzy FREE FATTY ACID
RECEPTOR
1,ENDOLYSIN,FREE
FATTY ACID RECEPTOR
1

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 HIS A  86
VAL A2269
LEU A  55
ALA A2266
 None
 1.43A 6d8pB-5tzyA:
undetectable		 6d8pB-5tzyA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w15 ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Burkholderia
ambifaria) 		PF12697
(Abhydrolase_6) 		4 HIS A  13
VAL A  70
LEU A  58
ALA A  68
 None
 1.33A 6d8pB-5w15A:
3.5		 6d8pB-5w15A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xde THERMOPHILIC
DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME C

(Paenibacillus
sp. A11-2) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		4 HIS A 257
VAL A 341
LEU A 253
ALA A 313
 None
 1.00A 6d8pB-5xdeA:
undetectable		 6d8pB-5xdeA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a2f -

(-) 		no annotation 4 HIS A  40
VAL A 330
LEU A 345
ALA A 233
 None
 1.16A 6d8pB-6a2fA:
undetectable		 6d8pB-6a2fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ams BETA SLIDING CLAMP

(Pseudomonas
aeruginosa) 		no annotation 4 HIS A 351
VAL A 361
LEU A 349
ALA A 359
 None
 1.29A 6d8pB-6amsA:
undetectable		 6d8pB-6amsA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bar ROD SHAPE
DETERMINING PROTEIN
RODA

(Thermus
thermophilus) 		no annotation 4 HIS A 176
VAL A 163
LEU A 177
ALA A 137
 None
 1.23A 6d8pB-6barA:
undetectable		 6d8pB-6barA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
NADH-PLASTOQUINONE
OXIDOREDUCTASE
SUBUNIT

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		no annotation
no annotation 		4 HIS J 141
VAL J 127
LEU J 145
ALA N 101
 None
 1.30A 6d8pB-6cfwJ:
3.9		 6d8pB-6cfwJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckc METHYLOSOME PROTEIN
50

(Homo sapiens) 		no annotation 4 HIS B 325
VAL B 300
LEU B 280
ALA B 295
 None
 1.37A 6d8pB-6ckcB:
undetectable		 6d8pB-6ckcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d95 -

(-) 		no annotation 4 HIS A 639
VAL A 685
LEU A 702
ALA A 737
 None
None
None
U  B   5 ( 3.5A)
 0.13A 6d8pB-6d95A:
61.8		 6d8pB-6d95A:
undetectable