SIMILAR PATTERNS OF AMINO ACIDS FOR 6D8P_B_ACTB803

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqu BETA-FRUCTOFURANOSID
ASE

(Arabidopsis
thaliana) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 MET A 416
TYR A 520
ARG A 453
LEU A 423
 None
 1.43A 6d8pB-2qquA:
0.2		 6d8pB-2qquA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN

(Escherichia
coli) 		PF13247
(Fer4_11)
PF14711
(Nitr_red_bet_C) 		4 MET B 333
TYR B 269
ARG B 445
LEU B 447
 None
 1.01A 6d8pB-3egwB:
0.0		 6d8pB-3egwB:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Danio rerio) 		PF12940
(RAG1) 		4 MET A 763
TYR A 950
ARG A 756
LEU A 958
 None
 1.49A 6d8pB-3jbyA:
1.9		 6d8pB-3jbyA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d95 -

(-) 		no annotation 4 MET A 528
TYR A 571
ARG A 606
LEU A 608
 None
None
U  B  13 ( 3.0A)
None
 0.68A 6d8pB-6d95A:
61.8		 6d8pB-6d95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbr -

(-) 		no annotation 4 MET A 763
TYR A 950
ARG A 756
LEU A 958
 None
 1.28A 6d8pB-6dbrA:
1.3		 6d8pB-6dbrA:
undetectable