SIMILAR PATTERNS OF AMINO ACIDS FOR 6D8F_A_ACTA803

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		3 GLU A 519
LEU A 518
ARG A 475
 None
 0.74A 6d8fA-1c2oA:
2.0		 6d8fA-1c2oA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqc EXO-(B)-(1,3)-GLUCAN
ASE

(Candida
albicans) 		PF00150
(Cellulase) 		3 GLU A 117
LEU A 120
ARG A 124
 None
 0.73A 6d8fA-1eqcA:
1.6		 6d8fA-1eqcA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl6 ATPASE

(Escherichia
coli) 		PF10412
(TrwB_AAD_bind) 		3 GLU A 399
LEU A 403
ARG A 404
 None
 0.53A 6d8fA-1gl6A:
0.0		 6d8fA-1gl6A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhm S-ADENOSYLMETHIONINE
DECARBOXYLASE

(Solanum
tuberosum) 		PF01536
(SAM_decarbox) 		3 GLU A 278
LEU A 281
ARG A 336
 None
 0.81A 6d8fA-1mhmA:
undetectable		 6d8fA-1mhmA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0x METHIONINE
AMINOPEPTIDASE

(Thermotoga
maritima) 		PF00557
(Peptidase_M24) 		3 GLU A 127
LEU A 128
ARG A 233
 None
 0.83A 6d8fA-1o0xA:
undetectable		 6d8fA-1o0xA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poj ISOASPARTYL
DIPEPTIDASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		3 GLU A 239
LEU A 242
ARG A 246
 None
 0.56A 6d8fA-1pojA:
0.0		 6d8fA-1pojA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pv9 XAA-PRO DIPEPTIDASE

(Pyrococcus
furiosus) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		3 GLU A 313
LEU A 282
ARG A 266
 ZN  A 401 (-2.6A)
None
None
 0.66A 6d8fA-1pv9A:
0.0		 6d8fA-1pv9A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vki HYPOTHETICAL PROTEIN
ATU3699

(Agrobacterium
fabrum) 		PF04073
(tRNA_edit) 		3 GLU A  36
LEU A  40
ARG A  41
 None
 0.77A 6d8fA-1vkiA:
undetectable		 6d8fA-1vkiA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcx UROPORPHYRINOGEN III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		3 GLU A 176
LEU A 179
ARG A 215
 None
 0.82A 6d8fA-1wcxA:
0.0		 6d8fA-1wcxA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy2 XAA-PRO DIPEPTIDASE

(Pyrococcus
horikoshii) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		3 GLU A 316
LEU A 285
ARG A 269
 ZN  A 406 ( 2.5A)
None
None
 0.69A 6d8fA-1wy2A:
undetectable		 6d8fA-1wy2A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4f MATRIN 3

(Mus musculus) 		PF00076
(RRM_1) 		3 GLU A  23
LEU A  24
ARG A  26
 None
 0.64A 6d8fA-1x4fA:
1.9		 6d8fA-1x4fA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		3 GLU A 199
LEU A 197
ARG A 136
 None
 0.77A 6d8fA-2b9eA:
undetectable		 6d8fA-2b9eA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d8m DNA-REPAIR PROTEIN
XRCC1

(Homo sapiens) 		PF00533
(BRCT) 		3 GLU A  87
LEU A  90
ARG A  94
 None
 0.82A 6d8fA-2d8mA:
2.6		 6d8fA-2d8mA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		3 GLU A 778
LEU A 738
ARG A 739
 None
 0.78A 6d8fA-2gj4A:
2.1		 6d8fA-2gj4A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg6 HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF09634
(DUF2025) 		3 GLU A  85
LEU A  88
ARG A  92
 None
 0.61A 6d8fA-2hg6A:
undetectable		 6d8fA-2hg6A:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hls PROTEIN DISULFIDE
OXIDOREDUCTASE

(Aeropyrum
pernix) 		PF13192
(Thioredoxin_3) 		3 GLU A 126
LEU A 125
ARG A 117
 None
 0.73A 6d8fA-2hlsA:
undetectable		 6d8fA-2hlsA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hq9 MLL6688 PROTEIN

(Mesorhizobium
loti) 		PF12900
(Pyridox_ox_2) 		3 GLU A  88
LEU A  89
ARG A  99
 None
 0.81A 6d8fA-2hq9A:
undetectable		 6d8fA-2hq9A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is3 RIBONUCLEASE T

(Escherichia
coli) 		PF00929
(RNase_T) 		3 GLU A 196
LEU A 193
ARG A 189
 None
None
SO4  A 217 (-3.5A)
 0.79A 6d8fA-2is3A:
undetectable		 6d8fA-2is3A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jr6 UPF0434 PROTEIN
NMA0874

(Neisseria
meningitidis) 		PF03966
(Trm112p) 		3 GLU A  55
LEU A  58
ARG A  30
 None
 0.78A 6d8fA-2jr6A:
undetectable		 6d8fA-2jr6A:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m33 CYTOCHROME B5

(Oryctolagus
cuniculus) 		PF00173
(Cyt-b5) 		3 GLU A  42
LEU A  41
ARG A  52
 None
 0.79A 6d8fA-2m33A:
undetectable		 6d8fA-2m33A:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2msy HOMEOBOX PROTEIN
HOX-C9

(Homo sapiens) 		PF00046
(Homeobox) 		3 GLU A  25
LEU A  24
ARG A  60
 None
 0.76A 6d8fA-2msyA:
undetectable		 6d8fA-2msyA:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ou3 TELLURITE RESISTANCE
PROTEIN OF COG3793

(Nostoc
punctiforme) 		PF05099
(TerB) 		3 GLU A 142
LEU A 145
ARG A 149
 None
 0.73A 6d8fA-2ou3A:
undetectable		 6d8fA-2ou3A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qde MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Aromatoleum
aromaticum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLU A 151
LEU A 154
ARG A 158
 None
 0.83A 6d8fA-2qdeA:
undetectable		 6d8fA-2qdeA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qed HYDROXYACYLGLUTATHIO
NE HYDROLASE

(Salmonella
enterica) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		3 GLU A 227
LEU A 224
ARG A 218
 None
 0.66A 6d8fA-2qedA:
undetectable		 6d8fA-2qedA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qeq FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT

(West Nile virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		3 GLU A 371
LEU A 374
ARG A 378
 None
 0.67A 6d8fA-2qeqA:
2.7		 6d8fA-2qeqA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r14 MORPHINONE REDUCTASE

(Pseudomonas
putida) 		PF00724
(Oxidored_FMN) 		3 GLU A 244
LEU A 248
ARG A 110
 None
 0.82A 6d8fA-2r14A:
2.2		 6d8fA-2r14A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rif CONSERVED PROTEIN
WITH 2 CBS DOMAINS

(Pyrobaculum
aerophilum) 		PF00571
(CBS) 		3 GLU A  53
LEU A  57
ARG A  58
 None
None
AMP  A 301 (-3.6A)
 0.69A 6d8fA-2rifA:
undetectable		 6d8fA-2rifA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsg VARIANT SURFACE
GLYCOPROTEIN ILTAT
1.24

(Trypanosoma
brucei) 		PF00913
(Trypan_glycop) 		3 GLU A  60
LEU A  64
ARG A  65
 None
 0.68A 6d8fA-2vsgA:
undetectable		 6d8fA-2vsgA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F

(Drosophila
melanogaster) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		3 GLU A 905
LEU A 908
ARG A 872
 None
 0.74A 6d8fA-2x6kA:
undetectable		 6d8fA-2x6kA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yx0 RADICAL SAM ENZYME

(Pyrococcus
horikoshii) 		PF04055
(Radical_SAM)
PF08608
(Wyosine_form) 		3 GLU A  99
LEU A 155
ARG A 184
 None
 0.63A 6d8fA-2yx0A:
undetectable		 6d8fA-2yx0A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze0 ALPHA-GLUCOSIDASE

(Geobacillus sp.
HTA-462) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 GLU A 467
LEU A 468
ARG A 489
 None
 0.83A 6d8fA-2ze0A:
undetectable		 6d8fA-2ze0A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350

(Thermus
thermophilus) 		PF00582
(Usp) 		3 GLU A 101
LEU A 104
ARG A 108
 GLU  A 101 ( 0.6A)
LEU  A 104 ( 0.6A)
ARG  A 108 ( 0.6A)
 0.66A 6d8fA-3ab7A:
2.7		 6d8fA-3ab7A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0m PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA/MSRB 1

(Streptococcus
pneumoniae) 		PF01625
(PMSR)
PF01641
(SelR) 		3 GLU A  66
LEU A  69
ARG A  73
 None
 0.61A 6d8fA-3e0mA:
undetectable		 6d8fA-3e0mA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		3 GLU A 207
LEU A 262
ARG A 261
 GOL  A 296 (-3.0A)
None
None
 0.70A 6d8fA-3f3zA:
undetectable		 6d8fA-3f3zA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8d BIOTIN CARBOXYLASE

(Escherichia
coli) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 GLU A 311
LEU A 308
ARG A  16
 None
 0.64A 6d8fA-3g8dA:
3.5		 6d8fA-3g8dA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyd CYCLIC
NUCLEOTIDE-BINDING
DOMAIN

(Methylobacillus
flagellatus) 		PF00027
(cNMP_binding) 		3 GLU A  97
LEU A 144
ARG A 143
 CMP  A 300 (-2.8A)
None
None
 0.59A 6d8fA-3gydA:
undetectable		 6d8fA-3gydA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihm STYRENE
MONOOXYGENASE A

(Pseudomonas
putida) 		no annotation 3 GLU A  58
LEU A  61
ARG A 115
 None
 0.77A 6d8fA-3ihmA:
undetectable		 6d8fA-3ihmA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izy TRANSLATION
INITIATION FACTOR
IF-2, MITOCHONDRIAL

(Bos taurus) 		PF00009
(GTP_EFTU)
PF11987
(IF-2) 		3 GLU P 543
LEU P 614
ARG P 613
 None
 0.71A 6d8fA-3izyP:
undetectable		 6d8fA-3izyP:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9t V-TYPE PROTON ATPASE
SUBUNIT E

(Saccharomyces
cerevisiae) 		no annotation 3 GLU K 213
LEU K 210
ARG K 206
 None
 0.68A 6d8fA-3j9tK:
undetectable		 6d8fA-3j9tK:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0s DNA MISMATCH REPAIR
PROTEIN MUTS

(Escherichia
coli) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		3 GLU A 122
LEU A 125
ARG A 305
 None
 0.77A 6d8fA-3k0sA:
undetectable		 6d8fA-3k0sA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF07497
(Rho_RNA_bind)
PF07498
(Rho_N) 		3 GLU A 372
LEU A 375
ARG A 151
 None
 0.71A 6d8fA-3l0oA:
undetectable		 6d8fA-3l0oA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n28 PHOSPHOSERINE
PHOSPHATASE

(Vibrio cholerae) 		PF00702
(Hydrolase) 		3 GLU A 167
LEU A 170
ARG A 174
 None
 0.82A 6d8fA-3n28A:
undetectable		 6d8fA-3n28A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngw MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
A (MOBA)

(Archaeoglobus
fulgidus) 		PF12804
(NTP_transf_3) 		3 GLU A 137
LEU A 138
ARG A  81
 None
None
CA  A 209 ( 4.7A)
 0.80A 6d8fA-3ngwA:
undetectable		 6d8fA-3ngwA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		3 GLU A1094
LEU A1098
ARG A1099
 None
 0.74A 6d8fA-3s5kA:
undetectable		 6d8fA-3s5kA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9v ABIETADIENE
SYNTHASE,
CHLOROPLASTIC

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 GLU A 468
LEU A 471
ARG A 475
 None
 0.71A 6d8fA-3s9vA:
undetectable		 6d8fA-3s9vA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdi PROTEASOME COMPONENT
PRE5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		3 GLU E 204
LEU E 201
ARG E 168
 None
 0.69A 6d8fA-3sdiE:
undetectable		 6d8fA-3sdiE:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqo CYSTEINYL-TRNA
SYNTHETASE

(Coxiella
burnetii) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		3 GLU A 101
LEU A 104
ARG A 291
 None
 0.69A 6d8fA-3tqoA:
3.0		 6d8fA-3tqoA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/DEOXYRIBONU
CLEASE SUBUNIT B

(Bacillus
subtilis) 		PF12705
(PDDEXK_1) 		3 GLU B 124
LEU B  96
ARG B  97
 None
 0.78A 6d8fA-3u44B:
undetectable		 6d8fA-3u44B:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ui2 SIGNAL RECOGNITION
PARTICLE 43 KDA
PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF12796
(Ank_2) 		3 GLU A 298
LEU A 288
ARG A 279
 None
 0.75A 6d8fA-3ui2A:
undetectable		 6d8fA-3ui2A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um1 BRO1
DOMAIN-CONTAINING
PROTEIN BROX

(Homo sapiens) 		PF03097
(BRO1) 		3 GLU A 231
LEU A 230
ARG A 178
 None
 0.78A 6d8fA-3um1A:
undetectable		 6d8fA-3um1A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus) 		PF00708
(Acylphosphatase)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		3 GLU A 273
LEU A 276
ARG A 281
 None
 0.53A 6d8fA-3vthA:
3.0		 6d8fA-3vthA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		3 GLU A 448
LEU A 451
ARG A 455
 None
 0.74A 6d8fA-3wbkA:
5.1		 6d8fA-3wbkA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whe HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 GLU A  82
LEU A 118
ARG A 150
 None
None
NAG  A 608 ( 4.0A)
 0.77A 6d8fA-3wheA:
undetectable		 6d8fA-3wheA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4

(Mus musculus) 		PF00225
(Kinesin) 		3 GLU A 254
LEU A 258
ARG A 259
 None
 0.24A 6d8fA-3zfcA:
undetectable		 6d8fA-3zfcA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia porcellus) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		3 GLU A 605
LEU A 540
ARG A 536
 None
 0.80A 6d8fA-4bc7A:
undetectable		 6d8fA-4bc7A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7n MICROPHTHALMIA
ASSOCIATED
TRANSCRIPTION FACTOR
SYNTHETIC
ALPHA-HELIX, IM10

(Homo sapiens;
synthetic
construct) 		no annotation
no annotation 		3 GLU A  19
LEU A  20
ARG B  17
 None
 0.82A 6d8fA-4c7nA:
undetectable		 6d8fA-4c7nA:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3a SUGAR KINASE PROTEIN

(Rhizobium etli) 		PF00294
(PfkB) 		3 GLU A 165
LEU A 168
ARG A 172
 None
 0.71A 6d8fA-4e3aA:
undetectable		 6d8fA-4e3aA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fml VSDC

(Aeromonas
hydrophila) 		PF03496
(ADPrib_exo_Tox) 		3 GLU A 131
LEU A 134
ARG A 202
 None
 0.81A 6d8fA-4fmlA:
undetectable		 6d8fA-4fmlA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr2 1,3-PROPANEDIOL
DEHYDROGENASE

(Oenococcus oeni) 		PF00465
(Fe-ADH) 		3 GLU A 294
LEU A 297
ARG A 372
 None
 0.81A 6d8fA-4fr2A:
undetectable		 6d8fA-4fr2A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9i HYDROGENASE
MATURATION PROTEIN
HYPF

(Thermococcus
kodakarensis) 		PF00708
(Acylphosphatase)
PF00814
(Peptidase_M22)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		3 GLU A 271
LEU A 274
ARG A 279
 None
 0.77A 6d8fA-4g9iA:
2.1		 6d8fA-4g9iA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hgz CCBJ

(Streptomyces
caelestis) 		PF13649
(Methyltransf_25) 		3 GLU A  71
LEU A  80
ARG A  81
 None
 0.64A 6d8fA-4hgzA:
undetectable		 6d8fA-4hgzA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2l GP41
INHIBITOR MTSFT

(Human
immunodeficiency
virus 1;
) 		no annotation
no annotation 		3 GLU D 647
LEU D 646
ARG C 557
 None
 0.81A 6d8fA-4i2lD:
undetectable		 6d8fA-4i2lD:
3.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Sinorhizobium
meliloti) 		PF04452
(Methyltrans_RNA) 		3 GLU A 204
LEU A 208
ARG A 209
 None
 0.82A 6d8fA-4j3cA:
undetectable		 6d8fA-4j3cA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jq5 NUCLEOPORIN P58/P45

(Homo sapiens) 		PF15967
(Nucleoporin_FG2) 		3 GLU A 340
LEU A 343
ARG A 347
 None
 0.75A 6d8fA-4jq5A:
undetectable		 6d8fA-4jq5A:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzt DGTP
PYROPHOSPHOHYDROLASE

(Bacillus
subtilis) 		PF00293
(NUDIX) 		3 GLU A  63
LEU A  66
ARG A  76
 None
 0.66A 6d8fA-4jztA:
undetectable		 6d8fA-4jztA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mv3 BIOTIN CARBOXYLASE

(Haemophilus
influenzae) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 GLU A 311
LEU A 308
ARG A  16
 None
 0.68A 6d8fA-4mv3A:
undetectable		 6d8fA-4mv3A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		3 GLU A1094
LEU A1097
ARG A1101
 None
 0.56A 6d8fA-4n78A:
undetectable		 6d8fA-4n78A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n8g TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Chromohalobacter
salexigens) 		PF03480
(DctP) 		3 GLU A 301
LEU A 304
ARG A 308
 None
 0.65A 6d8fA-4n8gA:
undetectable		 6d8fA-4n8gA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oog RIBONUCLEASE 3

(Saccharomyces
cerevisiae) 		PF00035
(dsrm)
PF00636
(Ribonuclease_3) 		3 GLU C 265
LEU C 268
ARG C 272
 U  D   3 ( 4.7A)
None
C  D   1 ( 3.5A)
 0.81A 6d8fA-4oogC:
undetectable		 6d8fA-4oogC:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uis GAMMA-SECRETASE

(Homo sapiens) 		PF05450
(Nicastrin) 		3 GLU A 474
LEU A 477
ARG A 520
 None
 0.61A 6d8fA-4uisA:
undetectable		 6d8fA-4uisA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x28 ACYL-COA
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		no annotation 3 GLU D  31
LEU D  32
ARG D 342
 None
 0.76A 6d8fA-4x28D:
undetectable		 6d8fA-4x28D:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi3 CILIA- AND
FLAGELLA-ASSOCIATED
PROTEIN 36

(Mus musculus) 		PF11527
(ARL2_Bind_BART) 		3 GLU D 119
LEU D 122
ARG D 126
 None
 0.64A 6d8fA-4zi3D:
undetectable		 6d8fA-4zi3D:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Escherichia
coli;
Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		3 GLU A 815
LEU A 739
ARG A 740
 None
 0.75A 6d8fA-5azaA:
undetectable		 6d8fA-5azaA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3k UNCHARACTERIZED
PROTEIN PA3435

(Pseudomonas
aeruginosa) 		PF00258
(Flavodoxin_1) 		3 GLU A  49
LEU A  84
ARG A 117
 None
 0.79A 6d8fA-5b3kA:
2.4		 6d8fA-5b3kA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		3 GLU A 339
LEU A 342
ARG A 349
 None
 0.77A 6d8fA-5cwaA:
undetectable		 6d8fA-5cwaA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5de0 DEFERROCHELATASE

(Vibrio cholerae) 		PF04261
(Dyp_perox) 		3 GLU A 206
LEU A 205
ARG A 197
 None
None
HEM  A 401 (-4.8A)
 0.71A 6d8fA-5de0A:
undetectable		 6d8fA-5de0A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC

(Bacillus
subtilis) 		PF00698
(Acyl_transf_1) 		3 GLU A 103
LEU A 106
ARG A 110
 None
 0.52A 6d8fA-5dz6A:
undetectable		 6d8fA-5dz6A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epa SNOK

(Streptomyces
nogalater) 		PF05721
(PhyH) 		3 GLU A 131
LEU A 132
ARG A 207
 None
 0.65A 6d8fA-5epaA:
undetectable		 6d8fA-5epaA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 GLU A 460
LEU A 459
ARG A 346
 None
 0.77A 6d8fA-5g3fA:
undetectable		 6d8fA-5g3fA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjn LYSINE/ORNITHINE
DECARBOXYLASE

(Selenomonas
ruminantium) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		3 GLU A 192
LEU A 195
ARG A 199
 None
 0.68A 6d8fA-5gjnA:
3.6		 6d8fA-5gjnA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		3 GLU A 917
LEU A 890
ARG A 853
 G1P  A1201 (-3.6A)
None
None
 0.71A 6d8fA-5h42A:
undetectable		 6d8fA-5h42A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6x RNA POLYMERASE SIGMA
FACTOR RPOS

(Legionella
pneumophila) 		no annotation 3 GLU A 127
LEU A 130
ARG A 131
 None
 0.77A 6d8fA-5h6xA:
undetectable		 6d8fA-5h6xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ij6 LIPOATE--PROTEIN
LIGASE

(Enterococcus
faecalis) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		3 GLU A  52
LEU A  43
ARG A  68
 None
None
LPA  A 401 (-3.5A)
 0.68A 6d8fA-5ij6A:
undetectable		 6d8fA-5ij6A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip7 DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5

(Saccharomyces
cerevisiae) 		PF01194
(RNA_pol_N) 		3 GLU J  32
LEU J  51
ARG J  47
 None
 0.81A 6d8fA-5ip7J:
undetectable		 6d8fA-5ip7J:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jj4 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SINGLE-STRAN
DED DNA CYTOSINE
DEAMINASE

(Escherichia
coli;
Homo sapiens) 		no annotation 3 GLU C1122
LEU C1126
ARG C1127
 None
 0.76A 6d8fA-5jj4C:
3.4		 6d8fA-5jj4C:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k2m RIMK-RELATED LYSINE
BIOSYNTHESIS PROTEIN

(Thermococcus
kodakarensis) 		PF08443
(RimK) 		3 GLU A  66
LEU A  62
ARG A  61
 None
 0.82A 6d8fA-5k2mA:
undetectable		 6d8fA-5k2mA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kan HEMAGGLUTININ HA1

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 GLU A  82
LEU A 118
ARG A 150
 None
None
NAG  A 403 ( 4.9A)
 0.82A 6d8fA-5kanA:
undetectable		 6d8fA-5kanA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5keu TAURINE DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF02668
(TauD) 		3 GLU A 152
LEU A 149
ARG A  50
 None
 0.82A 6d8fA-5keuA:
undetectable		 6d8fA-5keuA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkp PSEUDOURIDYLATE
SYNTHASE 7

(Homo sapiens) 		PF01142
(TruD) 		3 GLU A 445
LEU A 449
ARG A 450
 None
 0.66A 6d8fA-5kkpA:
undetectable		 6d8fA-5kkpA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lf5 MYELIN-ASSOCIATED
GLYCOPROTEIN

(Mus musculus) 		PF08205
(C2-set_2)
PF13927
(Ig_3) 		3 GLU A  34
LEU A 107
ARG A  88
 None
 0.73A 6d8fA-5lf5A:
undetectable		 6d8fA-5lf5A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nla PUTATIVE
TRANSCRIPTIONAL
REGULATOR
TRANSCRIPTION
REGULATOR PROTEIN

(Sinorhizobium
meliloti) 		PF12833
(HTH_18)
PF14525
(AraC_binding_2) 		3 GLU A 209
LEU A 212
ARG A  48
 None
 0.81A 6d8fA-5nlaA:
undetectable		 6d8fA-5nlaA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t81 EPOB

(Sorangium
cellulosum) 		PF00668
(Condensation) 		3 GLU A 159
LEU A 162
ARG A 166
 None
 0.64A 6d8fA-5t81A:
undetectable		 6d8fA-5t81A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpt AMYLOID-LIKE PROTEIN
2

(Homo sapiens) 		no annotation 3 GLU A 461
LEU A 464
ARG A 468
 None
 0.74A 6d8fA-5tptA:
undetectable		 6d8fA-5tptA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		PF13281
(DUF4071) 		3 GLU A 274
LEU A 277
ARG A 281
 None
 0.46A 6d8fA-5ulmA:
undetectable		 6d8fA-5ulmA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn6 TAURINE DIOXYGENASE

(Burkholderia
ambifaria) 		PF02668
(TauD) 		3 GLU A 135
LEU A 132
ARG A  40
 None
 0.40A 6d8fA-5vn6A:
undetectable		 6d8fA-5vn6A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9r HYDROXYETHYLPHOSPHON
ATE DIOXYGENASE

(Streptomyces
albus) 		no annotation 3 GLU A  36
LEU A  39
ARG A  63
 None
 0.80A 6d8fA-6b9rA:
undetectable		 6d8fA-6b9rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnp UNCONVENTIONAL
MYOSIN-VI

(Sus scrofa) 		no annotation 3 GLU I 332
LEU I 335
ARG I 339
 None
 0.81A 6d8fA-6bnpI:
undetectable		 6d8fA-6bnpI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d95 -

(-) 		no annotation 3 GLU A 377
LEU A 380
ARG A 384
 None
 0.18A 6d8fA-6d95A:
64.4		 6d8fA-6d95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dcl HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN A1

(Homo sapiens) 		no annotation 3 GLU A   9
LEU A  13
ARG A  88
 None
 0.81A 6d8fA-6dclA:
2.7		 6d8fA-6dclA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et0 PQSB

(Pseudomonas
aeruginosa) 		no annotation 3 GLU B 242
LEU B 243
ARG B 126
 None
 0.82A 6d8fA-6et0B:
undetectable		 6d8fA-6et0B:
undetectable