SIMILAR PATTERNS OF AMINO ACIDS FOR 6D6U_D_FYPD410

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxm A-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF02196
(RBD) 		5 SER A  29
ASP A  64
TYR A  31
ALA A  62
THR A  61
 None
 1.28A 6d6uD-1wxmA:
0.0
6d6uE-1wxmA:
undetectable		 6d6uD-1wxmA:
12.04
6d6uE-1wxmA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE

(Photobacterium
phosphoreum) 		PF11477
(PM0188) 		5 SER A 359
SER A 360
ASP A 148
ALA A  48
THR A  49
 C5P  A   1 (-2.6A)
C5P  A   1 ( 2.6A)
GOL  A   5 (-3.5A)
None
C5P  A   1 (-4.1A)
 1.18A 6d6uD-2zwiA:
0.0
6d6uE-2zwiA:
0.0		 6d6uD-2zwiA:
20.43
6d6uE-2zwiA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		5 SER A 248
TYR A 199
TYR A 340
ALA A 344
THR A 212
 None
 1.47A 6d6uD-3sghA:
1.4
6d6uE-3sghA:
0.6		 6d6uD-3sghA:
20.00
6d6uE-3sghA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-2,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT BETA-2
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		5 TYR A 157
SER A 201
TYR A 205
ASP B  44
THR B 130
 ABU  A 405 (-4.4A)
None
ABU  A 405 (-3.0A)
None
ABU  A 405 (-3.1A)
 0.81A 6d6uD-6d6uA:
19.5
6d6uE-6d6uA:
17.6		 6d6uD-6d6uA:
undetectable
6d6uE-6d6uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dw1


(;
) 		no annotation
no annotation 		6 HIS C 101
TYR C 159
SER C 204
SER C 205
ALA D  79
THR D 142
 None
 1.01A 6d6uD-6dw1C:
30.2
6d6uE-6dw1C:
27.0		 6d6uD-6dw1C:
undetectable
6d6uE-6dw1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dw1


(;
) 		no annotation
no annotation 		7 HIS C 101
TYR C 159
SER C 205
TYR C 209
TYR D  58
ALA D  79
THR D 142
 None
 0.62A 6d6uD-6dw1C:
30.2
6d6uE-6dw1C:
27.0		 6d6uD-6dw1C:
undetectable
6d6uE-6dw1C:
undetectable