SIMILAR PATTERNS OF AMINO ACIDS FOR 6CZM_F_HISF402

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddz CARBONIC ANHYDRASE

(Porphyridium
purpureum) 		PF00484
(Pro_CA) 		5 VAL A 421
LEU A 550
GLY A 402
VAL A 455
CYH A 457
 None
 0.90A 6czmE-1ddzA:
0.0
6czmF-1ddzA:
0.0		 6czmE-1ddzA:
20.94
6czmF-1ddzA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)

(Paracoccus
denitrificans) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 VAL A 301
LEU A 304
GLY A 292
LEU A 293
VAL A 254
 None
 1.09A 6czmE-1efpA:
0.0
6czmF-1efpA:
0.0		 6czmE-1efpA:
24.54
6czmF-1efpA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE F

(Bacillus
subtilis) 		PF00072
(Response_reg) 		5 VAL E1243
VAL E1278
LEU E1240
GLY E1262
VAL E1209
 None
 1.24A 6czmE-1f51E:
0.0
6czmF-1f51E:
0.0		 6czmE-1f51E:
16.43
6czmF-1f51E:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)

(Escherichia
coli) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 VAL A 384
VAL A 350
LEU A 385
GLY A 353
LEU A 354
 None
 1.32A 6czmE-1gsoA:
1.6
6czmF-1gsoA:
0.0		 6czmE-1gsoA:
21.13
6czmF-1gsoA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipi HOLLIDAY JUNCTION
RESOLVASE

(Pyrococcus
furiosus) 		PF01870
(Hjc) 		5 VAL A  77
VAL A 107
LEU A  43
GLY A 114
LEU A 113
 None
 1.29A 6czmE-1ipiA:
0.0
6czmF-1ipiA:
0.0		 6czmE-1ipiA:
16.29
6czmF-1ipiA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE

(Escherichia
coli) 		PF00218
(IGPS) 		5 VAL P 160
LEU P 138
GLY P 177
LEU P 176
VAL P 181
 None
 1.26A 6czmE-1jcmP:
0.0
6czmF-1jcmP:
0.0		 6czmE-1jcmP:
21.62
6czmF-1jcmP:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kz1 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

(Schizosaccharomyces
pombe) 		PF00885
(DMRL_synthase) 		5 VAL A 117
LEU A 106
GLY A  85
LEU A 121
VAL A  23
 None
 1.19A 6czmE-1kz1A:
0.1
6czmF-1kz1A:
0.0		 6czmE-1kz1A:
21.09
6czmF-1kz1A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzl RIBOFLAVIN SYNTHASE

(Schizosaccharomyces
pombe) 		PF00677
(Lum_binding) 		5 ASN A 181
VAL A 106
GLY A  74
LEU A  73
CYH A  76
 None
 1.20A 6czmE-1kzlA:
undetectable
6czmF-1kzlA:
2.1		 6czmE-1kzlA:
18.66
6czmF-1kzlA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7f AMPA RECEPTOR
INTERACTING PROTEIN
GRIP

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 VAL A 673
LEU A 748
GLY A 683
LEU A 682
THR A 710
 None
 1.12A 6czmE-1n7fA:
0.0
6czmF-1n7fA:
undetectable		 6czmE-1n7fA:
14.33
6czmF-1n7fA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC

(Klebsiella
pneumoniae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 VAL A  18
VAL A 172
LEU A  21
GLY A 106
LEU A 105
 None
 1.30A 6czmE-1ozhA:
undetectable
6czmF-1ozhA:
undetectable		 6czmE-1ozhA:
22.12
6czmF-1ozhA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ue0 ISOLEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1) 		5 VAL A 343
GLY A 356
LEU A 357
THR A 342
VAL A 351
 None
 1.14A 6czmE-1ue0A:
undetectable
6czmF-1ue0A:
undetectable		 6czmE-1ue0A:
21.51
6czmF-1ue0A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf1 KIAA1526 PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 VAL A  73
VAL A  87
LEU A  98
GLY A  35
LEU A  36
 None
 1.22A 6czmE-1uf1A:
undetectable
6czmF-1uf1A:
undetectable		 6czmE-1uf1A:
18.18
6czmF-1uf1A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwv 23S RRNA
(URACIL-5-)-METHYLTR
ANSFERASE RUMA

(Escherichia
coli) 		PF01938
(TRAM)
PF05958
(tRNA_U5-meth_tr) 		5 LEU A 219
GLY A 181
LEU A 183
VAL A 176
CYH A 179
 None
 1.22A 6czmE-1uwvA:
undetectable
6czmF-1uwvA:
undetectable		 6czmE-1uwvA:
23.82
6czmF-1uwvA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxd SHIKIMATE
5-DEHYDROGENASE

(Thermus
thermophilus) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 VAL A 203
ASN A 177
GLY A 123
LEU A 122
VAL A 131
 None
 1.25A 6czmE-1wxdA:
undetectable
6czmF-1wxdA:
undetectable		 6czmE-1wxdA:
23.37
6czmF-1wxdA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbs HYPOTHETICAL PROTEIN
PG1100

(Porphyromonas
gingivalis) 		PF01869
(BcrAD_BadFG) 		5 VAL A 225
VAL A 255
LEU A 229
GLY A 260
LEU A 261
 None
 1.12A 6czmE-1zbsA:
undetectable
6czmF-1zbsA:
undetectable		 6czmE-1zbsA:
24.75
6czmF-1zbsA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cff 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)
METHYLIDENEAMINO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Thermotoga
maritima) 		PF00977
(His_biosynth) 		5 VAL A  36
VAL A  14
LEU A  39
GLY A 223
VAL A  49
 None
 1.11A 6czmE-2cffA:
undetectable
6czmF-2cffA:
undetectable		 6czmE-2cffA:
21.81
6czmF-2cffA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4v ISOCITRATE
DEHYDROGENASE

(Acidithiobacillus
thiooxidans) 		PF00180
(Iso_dh) 		5 VAL A 322
VAL A 293
LEU A 326
GLN A 301
VAL A 312
 None
 0.97A 6czmE-2d4vA:
1.9
6czmF-2d4vA:
undetectable		 6czmE-2d4vA:
24.26
6czmF-2d4vA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7u ADENYLOSUCCINATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00709
(Adenylsucc_synt) 		5 VAL A  20
VAL A 220
LEU A  23
GLY A 321
LEU A 322
 None
 1.31A 6czmE-2d7uA:
undetectable
6czmF-2d7uA:
undetectable		 6czmE-2d7uA:
22.19
6czmF-2d7uA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eh6 ACETYLORNITHINE
AMINOTRANSFERASE

(Aquifex
aeolicus) 		PF00202
(Aminotran_3) 		5 VAL A 288
LEU A  75
GLY A 244
LEU A 243
VAL A 283
 None
 1.32A 6czmE-2eh6A:
undetectable
6czmF-2eh6A:
undetectable		 6czmE-2eh6A:
24.28
6czmF-2eh6A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5x BUGD

(Bordetella
pertussis) 		PF03401
(TctC) 		5 LEU A  26
GLY A  94
LEU A 247
GLN A 248
VAL A  97
 None
 1.17A 6czmE-2f5xA:
0.0
6czmF-2f5xA:
4.4		 6czmE-2f5xA:
23.22
6czmF-2f5xA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fm4 PYRUVATE, PHOSPHATE
DIKINASE

([Clostridium]
symbiosum) 		PF00391
(PEP-utilizers) 		5 VAL A 427
LEU A 446
GLY A 472
LEU A 485
CYH A 471
 None
 1.32A 6czmE-2fm4A:
undetectable
6czmF-2fm4A:
undetectable		 6czmE-2fm4A:
17.20
6czmF-2fm4A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0t CONSERVED
HYPOTHETICAL PROTEIN

(Thermotoga
maritima) 		PF07755
(DUF1611)
PF17396
(DUF1611_N) 		5 VAL A 208
LEU A   3
GLY A 198
LEU A 200
GLN A 196
 None
 1.33A 6czmE-2g0tA:
undetectable
6czmF-2g0tA:
undetectable		 6czmE-2g0tA:
24.21
6czmF-2g0tA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  37
VAL A  82
LEU A  29
LEU A 100
THR A 164
 J60  A1305 (-4.8A)
J60  A1305 ( 4.7A)
J60  A1305 (-3.9A)
J60  A1305 (-4.4A)
J60  A1305 ( 4.4A)
 1.29A 6czmE-2jamA:
undetectable
6czmF-2jamA:
undetectable		 6czmE-2jamA:
22.05
6czmF-2jamA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mii PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOB

(Escherichia
coli) 		PF13036
(LpoB) 		5 VAL A  89
LEU A 109
GLY A 190
GLN A 177
VAL A  72
 None
 1.11A 6czmE-2miiA:
undetectable
6czmF-2miiA:
undetectable		 6czmE-2miiA:
20.73
6czmF-2miiA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o14 HYPOTHETICAL PROTEIN
YXIM

(Bacillus
subtilis) 		PF13472
(Lipase_GDSL_2) 		5 ASN A 241
LEU A 238
GLY A 208
THR A 172
VAL A 173
 None
 1.18A 6czmE-2o14A:
undetectable
6czmF-2o14A:
undetectable		 6czmE-2o14A:
21.09
6czmF-2o14A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pn1 CARBAMOYLPHOSPHATE
SYNTHASE LARGE
SUBUNIT

(Exiguobacterium
sibiricum) 		PF02655
(ATP-grasp_3) 		5 VAL A 248
VAL A 100
GLY A  84
LEU A  83
CYH A 108
 None
 1.30A 6czmE-2pn1A:
undetectable
6czmF-2pn1A:
undetectable		 6czmE-2pn1A:
21.47
6czmF-2pn1A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3z TRANSGLUTAMINASE 2

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		5 VAL A 220
GLY A 292
LEU A 138
VAL A 287
CYH A 290
 None
 1.04A 6czmE-2q3zA:
undetectable
6czmF-2q3zA:
undetectable		 6czmE-2q3zA:
21.12
6czmF-2q3zA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vea PHYTOCHROME-LIKE
PROTEIN CPH1

(Synechocystis
sp. PCC 6803) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 VAL A 388
VAL A 422
LEU A 391
GLY A 425
LEU A 409
 None
 1.24A 6czmE-2veaA:
undetectable
6czmF-2veaA:
undetectable		 6czmE-2veaA:
22.68
6czmF-2veaA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2s MATRIX PROTEIN

(Lagos bat
lyssavirus) 		PF04785
(Rhabdo_M2) 		5 VAL A 157
LEU A 120
GLY A  98
LEU A  99
VAL A  92
 None
 1.22A 6czmE-2w2sA:
undetectable
6czmF-2w2sA:
undetectable		 6czmE-2w2sA:
21.57
6czmF-2w2sA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we8 XANTHINE
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF02625
(XdhC_CoxI)
PF13478
(XdhC_C) 		5 VAL A  43
LEU A 114
GLY A  10
LEU A   9
VAL A  15
 None
 1.07A 6czmE-2we8A:
undetectable
6czmF-2we8A:
undetectable		 6czmE-2we8A:
24.07
6czmF-2we8A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we8 XANTHINE
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF02625
(XdhC_CoxI)
PF13478
(XdhC_C) 		5 VAL A 196
VAL A 147
LEU A 181
GLY A 171
LEU A 172
 None
 0.86A 6czmE-2we8A:
undetectable
6czmF-2we8A:
undetectable		 6czmE-2we8A:
24.07
6czmF-2we8A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpa UNCHARACTERIZED
PROTEIN YPFI

(Escherichia
coli) 		PF05127
(Helicase_RecD)
PF08351
(DUF1726)
PF13718
(GNAT_acetyltr_2)
PF17176
(tRNA_bind_3) 		5 VAL A 260
LEU A 283
GLY A 204
LEU A 208
GLN A 211
 None
None
ADP  A 800 (-2.7A)
None
ADP  A 800 (-4.0A)
 1.22A 6czmE-2zpaA:
undetectable
6czmF-2zpaA:
undetectable		 6czmE-2zpaA:
21.16
6czmF-2zpaA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztu D(-)-3-HYDROXYBUTYRA
TE DEHYDROGENASE

(Pseudomonas
fragi) 		PF13561
(adh_short_C2) 		5 VAL A  57
VAL A   9
LEU A  49
GLY A  19
LEU A  18
 None
 1.16A 6czmE-2ztuA:
undetectable
6czmF-2ztuA:
undetectable		 6czmE-2ztuA:
23.24
6czmF-2ztuA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bji PROTO-ONCOGENE VAV

(Homo sapiens) 		PF00130
(C1_1)
PF00169
(PH)
PF00621
(RhoGEF) 		5 LEU A 278
LEU A 535
THR A 539
VAL A 373
CYH A 369
 None
 1.18A 6czmE-3bjiA:
undetectable
6czmF-3bjiA:
undetectable		 6czmE-3bjiA:
20.94
6czmF-3bjiA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj1 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 2

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		5 VAL A 143
VAL A  77
LEU A 147
LEU A 100
THR A  51
 None
 1.09A 6czmE-3cj1A:
undetectable
6czmF-3cj1A:
undetectable		 6czmE-3cj1A:
24.63
6czmF-3cj1A:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 VAL A 372
GLY A 386
LEU A 387
GLN A 383
VAL A 369
 None
 1.14A 6czmE-3d1jA:
1.5
6czmF-3d1jA:
undetectable		 6czmE-3d1jA:
23.54
6czmF-3d1jA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eiq PROGRAMMED CELL
DEATH PROTEIN 4

(Mus musculus) 		PF02847
(MA3) 		5 VAL C 200
VAL C 230
LEU C 168
LEU C 191
VAL C 184
 None
 1.30A 6czmE-3eiqC:
undetectable
6czmF-3eiqC:
undetectable		 6czmE-3eiqC:
23.19
6czmF-3eiqC:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3exs RMPD
(HEXULOSE-6-PHOSPHAT
E SYNTHASE)

(Streptococcus
mutans) 		PF00215
(OMPdecase) 		5 VAL A  51
VAL A  44
LEU A  52
GLY A  37
LEU A  12
 None
 1.20A 6czmE-3exsA:
undetectable
6czmF-3exsA:
undetectable		 6czmE-3exsA:
24.25
6czmF-3exsA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF00464
(SHMT) 		5 VAL A 344
VAL A 389
LEU A  32
GLY A 384
LEU A 382
 None
 1.28A 6czmE-3g8mA:
undetectable
6czmF-3g8mA:
undetectable		 6czmE-3g8mA:
23.71
6czmF-3g8mA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdz ARGINYL-TRNA
SYNTHETASE

(Klebsiella
pneumoniae) 		PF03485
(Arg_tRNA_synt_N) 		5 VAL A  11
LEU A   7
GLY A  37
GLN A  40
VAL A  75
 None
None
None
EDO  A 107 ( 2.9A)
None
 1.27A 6czmE-3gdzA:
undetectable
6czmF-3gdzA:
2.7		 6czmE-3gdzA:
14.49
6czmF-3gdzA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		5 LEU A 749
GLY A 772
LEU A 792
THR A 775
VAL A 774
 None
 1.12A 6czmE-3gsiA:
1.7
6czmF-3gsiA:
2.0		 6czmE-3gsiA:
18.65
6czmF-3gsiA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1q ETHANOLAMINE
UTILIZATION PROTEIN
EUTJ

(Carboxydothermus
hydrogenoformans) 		PF14450
(FtsA) 		5 LEU A  89
GLY A  51
LEU A  39
THR A  42
VAL A  49
 None
 1.21A 6czmE-3h1qA:
undetectable
6czmF-3h1qA:
undetectable		 6czmE-3h1qA:
24.86
6czmF-3h1qA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h77 PQS BIOSYNTHETIC
ENZYME

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 VAL A 137
LEU A 135
GLY A  99
LEU A 100
GLN A  95
 None
 1.11A 6czmE-3h77A:
undetectable
6czmF-3h77A:
undetectable		 6czmE-3h77A:
24.28
6czmF-3h77A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 4
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 5

(Thermus
thermophilus;
Thermus
thermophilus) 		PF00346
(Complex1_49kDa)
PF00329
(Complex1_30kDa) 		5 VAL 4 264
LEU 5  77
GLY 4 237
LEU 4 239
VAL 4 248
 None
 1.29A 6czmE-3i9v4:
undetectable
6czmF-3i9v4:
undetectable		 6czmE-3i9v4:
22.50
6czmF-3i9v4:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3keh GLUCOCEREBROSIDASE

(Homo sapiens) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		5 VAL A 460
LEU A 444
GLY A  64
LEU A  65
THR A 482
 None
 1.11A 6czmE-3kehA:
undetectable
6czmF-3kehA:
undetectable		 6czmE-3kehA:
22.51
6czmF-3kehA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvy CARBOXYMUCONOLACTONE
DECARBOXYLASE FAMILY

(Streptococcus
mutans) 		PF02627
(CMD) 		5 VAL A  16
GLY A  36
LEU A  38
THR A  19
VAL A  23
 None
 1.29A 6czmE-3lvyA:
undetectable
6czmF-3lvyA:
undetectable		 6czmE-3lvyA:
21.23
6czmF-3lvyA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Novosphingobium
aromaticivorans) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		5 VAL A 187
LEU A 340
GLY A 193
LEU A 196
VAL A 191
 None
 1.25A 6czmE-3lxdA:
undetectable
6czmF-3lxdA:
undetectable		 6czmE-3lxdA:
21.76
6czmF-3lxdA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwt NUCLEOPROTEIN

(Lassa
mammarenavirus) 		PF00843
(Arena_nucleocap)
PF17290
(Arena_ncap_C) 		5 VAL A 199
VAL A 193
LEU A 202
LEU A 229
THR A 188
 None
 1.20A 6czmE-3mwtA:
undetectable
6czmF-3mwtA:
undetectable		 6czmE-3mwtA:
20.70
6czmF-3mwtA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE

(Taxus
canadensis) 		PF00221
(Lyase_aromatic) 		5 LEU A 331
GLY A 259
LEU A 292
VAL A 254
CYH A 258
 None
 1.31A 6czmE-3nz4A:
undetectable
6czmF-3nz4A:
undetectable		 6czmE-3nz4A:
21.68
6czmF-3nz4A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm6 PUTATIVE
FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Coccidioides
immitis) 		PF01116
(F_bP_aldolase) 		5 VAL A 200
LEU A 202
LEU A 222
THR A 229
CYH A 236
 None
 1.31A 6czmE-3pm6A:
undetectable
6czmF-3pm6A:
undetectable		 6czmE-3pm6A:
21.62
6czmF-3pm6A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r27 HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN L

(Homo sapiens) 		PF00076
(RRM_1) 		5 VAL A 142
LEU A 118
GLY A 108
LEU A 109
VAL A 171
 None
 1.30A 6czmE-3r27A:
undetectable
6czmF-3r27A:
3.3		 6czmE-3r27A:
11.21
6czmF-3r27A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ruc WBGU

(Plesiomonas
shigelloides) 		PF01370
(Epimerase) 		5 VAL A  92
GLY A  45
THR A  18
VAL A  42
CYH A  73
 None
 1.03A 6czmE-3rucA:
undetectable
6czmF-3rucA:
undetectable		 6czmE-3rucA:
23.86
6czmF-3rucA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgg HYPOTHETICAL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF14323
(GxGYxYP_C)
PF16216
(GxGYxYP_N) 		5 VAL A 530
VAL A 540
GLY A 357
LEU A 356
VAL A 515
 None
 1.27A 6czmE-3sggA:
undetectable
6czmF-3sggA:
undetectable		 6czmE-3sggA:
22.30
6czmF-3sggA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5q NUCLEOPROTEIN

(Mopeia Lassa
virus
reassortant 29) 		PF00843
(Arena_nucleocap) 		5 VAL A 199
VAL A 193
LEU A 202
LEU A 229
THR A 188
 None
 1.17A 6czmE-3t5qA:
undetectable
6czmF-3t5qA:
undetectable		 6czmE-3t5qA:
23.43
6czmF-3t5qA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugm TAL EFFECTOR
AVRBS3/PTHA

(Xanthomonas
oryzae) 		PF03377
(TAL_effector) 		5 VAL A 547
VAL A 581
LEU A 551
GLN A 582
CYH A 555
 None
 1.31A 6czmE-3ugmA:
undetectable
6czmF-3ugmA:
undetectable		 6czmE-3ugmA:
17.69
6czmF-3ugmA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		5 LEU A 640
GLY A 605
LEU A 606
GLN A 619
THR A 622
 None
 1.08A 6czmE-3va6A:
undetectable
6czmF-3va6A:
undetectable		 6czmE-3va6A:
18.47
6czmF-3va6A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wkm PUTATIVE ZINC
METALLOPROTEASE
AQ_1964

(Aquifex
aeolicus) 		PF00595
(PDZ)
PF13180
(PDZ_2) 		5 VAL A 234
VAL A 246
LEU A 259
GLY A 286
LEU A 287
 None
 1.24A 6czmE-3wkmA:
undetectable
6czmF-3wkmA:
undetectable		 6czmE-3wkmA:
23.40
6czmF-3wkmA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF00111
(Fer2)
PF14574
(DUF4445) 		5 VAL X  49
VAL X  58
GLY X  62
LEU X  64
THR X  79
 None
 1.30A 6czmE-3zyyX:
undetectable
6czmF-3zyyX:
undetectable		 6czmE-3zyyX:
21.98
6czmF-3zyyX:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF00111
(Fer2)
PF14574
(DUF4445) 		5 VAL X  49
VAL X  58
LEU X  48
GLY X  62
LEU X  64
 None
 1.15A 6czmE-3zyyX:
undetectable
6czmF-3zyyX:
undetectable		 6czmE-3zyyX:
21.98
6czmF-3zyyX:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE

(Anaerococcus
prevotii) 		PF01071
(GARS_A) 		5 VAL A 259
VAL A 204
LEU A 273
GLY A 251
LEU A 252
 None
 1.33A 6czmE-4dimA:
undetectable
6czmF-4dimA:
undetectable		 6czmE-4dimA:
22.57
6czmF-4dimA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0j PROBABLE HYDROLYTIC
ENZYME

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		5 VAL A  88
LEU A  89
GLY A 330
LEU A 331
GLN A 332
 None
 1.26A 6czmE-4f0jA:
undetectable
6czmF-4f0jA:
undetectable		 6czmE-4f0jA:
23.21
6czmF-4f0jA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9u CG32412

(Drosophila
melanogaster) 		PF04389
(Peptidase_M28) 		5 VAL A 127
VAL A 295
LEU A  49
GLY A 221
LEU A 306
 None
 1.33A 6czmE-4f9uA:
undetectable
6czmF-4f9uA:
undetectable		 6czmE-4f9uA:
23.58
6czmF-4f9uA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqn SPOROZOITE SURFACE
PROTEIN 2

(Plasmodium
vivax) 		PF00090
(TSP_1)
PF00092
(VWA) 		5 VAL A  49
VAL A 114
GLY A  70
LEU A  71
VAL A  64
 None
 1.20A 6czmE-4hqnA:
undetectable
6czmF-4hqnA:
undetectable		 6czmE-4hqnA:
20.56
6czmF-4hqnA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxy PLM1

(Streptomyces
sp. HK803) 		PF08659
(KR) 		5 LEU A  67
LEU A 125
GLN A 157
VAL A  82
CYH A  84
 None
 1.07A 6czmE-4hxyA:
undetectable
6czmF-4hxyA:
undetectable		 6czmE-4hxyA:
23.87
6czmF-4hxyA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgu STRUCTURAL PROTEIN
VP2

(Orthopteran
ambidensovirus
1) 		PF02336
(Denso_VP4) 		5 LEU A 253
GLY A 397
LEU A 329
THR A 400
VAL A 311
 None
 1.24A 6czmE-4mguA:
undetectable
6czmF-4mguA:
undetectable		 6czmE-4mguA:
21.21
6czmF-4mguA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 VAL A  65
VAL A  82
LEU A  68
GLY A 102
VAL A  79
 None
 1.24A 6czmE-4mrqA:
undetectable
6czmF-4mrqA:
undetectable		 6czmE-4mrqA:
22.10
6czmF-4mrqA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oby ARGININE--TRNA
LIGASE

(Escherichia
coli) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		5 VAL A  11
LEU A   7
GLY A  37
GLN A  40
VAL A  75
 None
 1.32A 6czmE-4obyA:
undetectable
6czmF-4obyA:
3.1		 6czmE-4obyA:
22.88
6czmF-4obyA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe1 CHLOROPLAST
PENTATRICOPEPTIDE
REPEAT PROTEIN 10

(Zea mays) 		PF01535
(PPR)
PF12854
(PPR_1)
PF13041
(PPR_2)
PF13812
(PPR_3) 		5 LEU A 160
GLY A 149
LEU A 148
GLN A 153
VAL A 180
 None
 1.14A 6czmE-4oe1A:
undetectable
6czmF-4oe1A:
undetectable		 6czmE-4oe1A:
19.34
6czmF-4oe1A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 VAL A 675
VAL A 465
GLY A 503
LEU A 502
VAL A 506
 None
 1.21A 6czmE-4oqjA:
undetectable
6czmF-4oqjA:
undetectable		 6czmE-4oqjA:
20.09
6czmF-4oqjA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1

(Bos taurus) 		PF13516
(LRR_6) 		5 VAL B  99
LEU B  85
GLY B  74
LEU B  75
VAL B  68
 None
 1.25A 6czmE-4peqB:
undetectable
6czmF-4peqB:
undetectable		 6czmE-4peqB:
24.35
6czmF-4peqB:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvv ADENOSINE KINASE

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		5 VAL A 241
LEU A 307
GLY A 280
LEU A 279
VAL A 244
 None
 1.19A 6czmE-4pvvA:
undetectable
6czmF-4pvvA:
undetectable		 6czmE-4pvvA:
23.56
6czmF-4pvvA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1d UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 5 VAL A 147
ASN A 145
GLY A 135
VAL A 204
CYH A 206
 None
 1.17A 6czmE-4r1dA:
undetectable
6czmF-4r1dA:
undetectable		 6czmE-4r1dA:
21.56
6czmF-4r1dA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8l UNCHARACTERIZED
PROTEIN

(Cavia porcellus) 		PF00710
(Asparaginase) 		5 VAL A 264
ASN A 295
VAL A 304
GLY A 273
LEU A 312
 None
 1.30A 6czmE-4r8lA:
undetectable
6czmF-4r8lA:
undetectable		 6czmE-4r8lA:
23.98
6czmF-4r8lA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzo PROTEIN HTP-1
C. ELEGANS HIM-3
CLOSURE MOTIF

(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		PF02301
(HORMA)
no annotation 		5 ASN A 196
VAL A 111
LEU A  92
GLY B 280
VAL A 108
 None
 1.31A 6czmE-4tzoA:
undetectable
6czmF-4tzoA:
undetectable		 6czmE-4tzoA:
23.42
6czmF-4tzoA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xq7 2'-5'-OLIGOADENYLATE
SYNTHASE-LIKE
PROTEIN

(Homo sapiens) 		PF10421
(OAS1_C) 		5 VAL A  33
LEU A  34
GLY A  68
THR A  79
VAL A  75
 None
 1.32A 6czmE-4xq7A:
undetectable
6czmF-4xq7A:
undetectable		 6czmE-4xq7A:
21.46
6czmF-4xq7A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjw DUF3829 FAMILY
PROTEIN

(Bacteroides
vulgatus) 		no annotation 5 LEU A  54
GLY A 115
LEU A 117
THR A  92
VAL A  95
 None
 1.17A 6czmE-4yjwA:
undetectable
6czmF-4yjwA:
undetectable		 6czmE-4yjwA:
19.01
6czmF-4yjwA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2y CALO6

(Micromonospora
echinospora) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		5 VAL A 182
LEU A 247
GLN A 258
THR A 265
VAL A 266
 None
 1.33A 6czmE-4z2yA:
undetectable
6czmF-4z2yA:
undetectable		 6czmE-4z2yA:
22.78
6czmF-4z2yA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dne L-ASPARAGINASE

(Cavia porcellus) 		PF00710
(Asparaginase) 		5 VAL A 264
ASN A 295
VAL A 304
GLY A 273
LEU A 312
 None
 1.27A 6czmE-5dneA:
undetectable
6czmF-5dneA:
undetectable		 6czmE-5dneA:
21.90
6czmF-5dneA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8c UL34 PROTEIN

(Suid
alphaherpesvirus
1) 		PF04541
(Herpes_U34) 		5 VAL B 139
VAL B  40
LEU B  52
GLY B  84
VAL B  73
 None
 1.17A 6czmE-5e8cB:
undetectable
6czmF-5e8cB:
undetectable		 6czmE-5e8cB:
20.99
6czmF-5e8cB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus musculus) 		PF08696
(Dna2)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 VAL A 638
VAL A 673
LEU A 639
GLY A 670
CYH A 669
 None
 1.29A 6czmE-5eawA:
undetectable
6czmF-5eawA:
undetectable		 6czmE-5eawA:
17.70
6czmF-5eawA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkx UNCHARACTERIZED
PROTEIN

(Thermococcus
onnurineus) 		PF14336
(DUF4392) 		5 VAL A 204
VAL A  44
LEU A 215
GLY A  77
LEU A  76
 None
 1.20A 6czmE-5gkxA:
0.9
6czmF-5gkxA:
undetectable		 6czmE-5gkxA:
23.94
6czmF-5gkxA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h46 DNA PROTECTION
DURING STARVATION
PROTEIN

(Mycolicibacterium
smegmatis) 		PF00210
(Ferritin) 		5 VAL A  68
LEU A  21
LEU A 127
GLN A 135
THR A 120
 None
None
None
FE2  A 203 ( 4.8A)
None
 1.13A 6czmE-5h46A:
undetectable
6czmF-5h46A:
undetectable		 6czmE-5h46A:
22.08
6czmF-5h46A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5l BACTERIOPHYTOCHROME
PROTEIN

(Agrobacterium
fabrum) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 VAL A 381
VAL A 415
LEU A 384
GLY A 418
LEU A 402
 None
 1.19A 6czmE-5i5lA:
undetectable
6czmF-5i5lA:
undetectable		 6czmE-5i5lA:
22.01
6czmF-5i5lA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipf HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE (HGPRT)

(Schistosoma
mansoni) 		PF00156
(Pribosyltran) 		5 VAL A 189
VAL A 213
LEU A 170
GLY A 196
LEU A 199
 None
None
None
None
IMP  A1300 ( 4.4A)
 1.30A 6czmE-5ipfA:
undetectable
6czmF-5ipfA:
undetectable		 6czmE-5ipfA:
22.38
6czmF-5ipfA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jz7 MEDI578 SCFV, LIGHT
CHAIN

(Homo sapiens) 		PF07686
(V-set) 		5 VAL D  11
LEU D 104
GLY D  77
LEU D  78
GLN D  17
 None
 1.30A 6czmE-5jz7D:
undetectable
6czmF-5jz7D:
undetectable		 6czmE-5jz7D:
15.23
6czmF-5jz7D:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k69 L,D-TRANSPEPTIDASE 2

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		5 VAL A  79
GLY A 230
GLN A 117
THR A 145
VAL A  73
 None
 1.07A 6czmE-5k69A:
undetectable
6czmF-5k69A:
undetectable		 6czmE-5k69A:
21.78
6czmF-5k69A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lae PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE
OXIDASE,PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE OXIDASE

(Mus musculus) 		PF01593
(Amino_oxidase) 		5 VAL A  11
VAL A 261
LEU A  36
LEU A 271
CYH A 265
 FAD  A1801 (-4.6A)
None
None
None
None
 1.32A 6czmE-5laeA:
undetectable
6czmF-5laeA:
1.3		 6czmE-5laeA:
22.95
6czmF-5laeA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum) 		PF12708
(Pectate_lyase_3) 		5 VAL A 615
LEU A 576
GLY A 534
LEU A 535
VAL A 623
 None
 0.94A 6czmE-5m60A:
undetectable
6czmF-5m60A:
undetectable		 6czmE-5m60A:
20.08
6czmF-5m60A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdn DNA POLYMERASE

(Pyrobaculum
calidifontis) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 VAL A 228
LEU A 293
GLY A 342
LEU A 343
VAL A 337
 None
 1.29A 6czmE-5mdnA:
2.4
6czmF-5mdnA:
4.8		 6czmE-5mdnA:
19.70
6czmF-5mdnA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN

(Homo sapiens) 		no annotation 5 VAL L  10
LEU L 107
GLY L  78
LEU L  79
GLN L  16
 None
 1.32A 6czmE-5ocyL:
undetectable
6czmF-5ocyL:
undetectable		 6czmE-5ocyL:
undetectable
6czmF-5ocyL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t81 EPOB

(Sorangium
cellulosum) 		PF00668
(Condensation) 		5 VAL A 108
LEU A 111
GLY A 434
LEU A 433
THR A 194
 None
 1.30A 6czmE-5t81A:
undetectable
6czmF-5t81A:
1.6		 6czmE-5t81A:
20.88
6czmF-5t81A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tbx COLD-INDUCIBLE
RNA-BINDING PROTEIN

(Homo sapiens) 		PF00076
(RRM_1) 		5 VAL A  53
LEU A  23
GLY A  13
LEU A  14
VAL A  80
 None
 1.25A 6czmE-5tbxA:
undetectable
6czmF-5tbxA:
3.8		 6czmE-5tbxA:
14.53
6czmF-5tbxA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uu1 SERINE/THREONINE-PRO
TEIN KINASE VRK2

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 172
GLY A 147
LEU A 146
GLN A 145
VAL A 153
 None
 1.25A 6czmE-5uu1A:
undetectable
6czmF-5uu1A:
undetectable		 6czmE-5uu1A:
25.94
6czmF-5uu1A:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Acinetobacter
baumannii) 		PF00464
(SHMT) 		5 VAL A 343
VAL A 388
LEU A  31
GLY A 383
LEU A 381
 None
 1.30A 6czmE-5vmbA:
0.6
6czmF-5vmbA:
undetectable		 6czmE-5vmbA:
22.81
6czmF-5vmbA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ww1 PULULLANASE

(Paenibacillus
barengoltzii) 		no annotation 5 VAL A  87
GLY A 121
LEU A 122
THR A 152
CYH A 119
 None
 1.26A 6czmE-5ww1A:
undetectable
6czmF-5ww1A:
undetectable		 6czmE-5ww1A:
undetectable
6czmF-5ww1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b67 PROTEIN PHOSPHATASE
1A

(Homo sapiens) 		no annotation 5 VAL A 254
VAL A 286
LEU A 258
LEU A 264
CYH A 290
 None
 1.22A 6czmE-6b67A:
undetectable
6czmF-6b67A:
undetectable		 6czmE-6b67A:
undetectable
6czmF-6b67A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czm -

(-) 		no annotation 6 GLY A 300
LEU A 301
GLN A 302
THR A 305
VAL A 325
CYH A 327
 HIS  A 402 (-3.4A)
HIS  A 402 (-4.0A)
None
HIS  A 402 (-4.2A)
HIS  A 402 (-4.4A)
HIS  A 402 (-4.2A)
 0.24A 6czmE-6czmA:
42.8
6czmF-6czmA:
37.6		 6czmE-6czmA:
undetectable
6czmF-6czmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dxp -

(-) 		no annotation 5 LEU A  89
GLY A 161
LEU A 160
THR A 117
VAL A 129
 None
 1.23A 6czmE-6dxpA:
undetectable
6czmF-6dxpA:
undetectable		 6czmE-6dxpA:
undetectable
6czmF-6dxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fiv RETROPEPSIN

(Feline
immunodeficiency
virus) 		PF00077
(RVP) 		5 VAL A  20
LEU A  73
GLY A 103
LEU A 102
VAL A  89
 None
 1.08A 6czmE-6fivA:
undetectable
6czmF-6fivA:
undetectable		 6czmE-6fivA:
14.49
6czmF-6fivA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkq NETRIN-1

(Homo sapiens) 		no annotation 5 VAL A 147
VAL A 276
GLY A 216
LEU A 217
GLN A 150
 None
 1.18A 6czmE-6fkqA:
undetectable
6czmF-6fkqA:
undetectable		 6czmE-6fkqA:
undetectable
6czmF-6fkqA:
undetectable