SIMILAR PATTERNS OF AMINO ACIDS FOR 6CZM_E_HISE402_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddz CARBONIC ANHYDRASE

(Porphyridium
purpureum) 		PF00484
(Pro_CA) 		5 VAL A 368
VAL A 167
LEU A 296
GLY A 148
CYH A 203
 None
 1.26A 6czmD-1ddzA:
0.0
6czmE-1ddzA:
0.0		 6czmD-1ddzA:
20.94
6czmE-1ddzA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddz CARBONIC ANHYDRASE

(Porphyridium
purpureum) 		PF00484
(Pro_CA) 		5 VAL A 421
LEU A 550
GLY A 402
VAL A 455
CYH A 457
 None
 0.94A 6czmD-1ddzA:
0.0
6czmE-1ddzA:
0.0		 6czmD-1ddzA:
20.94
6czmE-1ddzA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)

(Paracoccus
denitrificans) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 VAL A 301
LEU A 304
GLY A 292
LEU A 293
VAL A 254
 None
 1.10A 6czmD-1efpA:
0.0
6czmE-1efpA:
0.0		 6czmD-1efpA:
24.54
6czmE-1efpA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE F

(Bacillus
subtilis) 		PF00072
(Response_reg) 		5 VAL E1243
VAL E1278
LEU E1240
GLY E1262
VAL E1209
 None
 1.25A 6czmD-1f51E:
1.8
6czmE-1f51E:
0.0		 6czmD-1f51E:
16.43
6czmE-1f51E:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)

(Escherichia
coli) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 VAL A 384
VAL A 350
LEU A 385
GLY A 353
LEU A 354
 None
 1.34A 6czmD-1gsoA:
0.7
6czmE-1gsoA:
1.6		 6czmD-1gsoA:
21.13
6czmE-1gsoA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyt CYTOSOL
AMINOPEPTIDASE

(Escherichia
coli) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 VAL A  19
LEU A 112
GLY A  54
THR A  59
CYH A  78
 None
 1.30A 6czmD-1gytA:
0.0
6czmE-1gytA:
0.0		 6czmD-1gytA:
21.06
6czmE-1gytA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hpl LIPASE

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 VAL A 398
VAL A 355
LEU A 446
GLY A 416
LEU A 444
 None
 1.35A 6czmD-1hplA:
0.0
6czmE-1hplA:
0.1		 6czmD-1hplA:
23.03
6czmE-1hplA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipi HOLLIDAY JUNCTION
RESOLVASE

(Pyrococcus
furiosus) 		PF01870
(Hjc) 		5 VAL A  77
VAL A 107
LEU A  43
GLY A 114
LEU A 113
 None
 1.30A 6czmD-1ipiA:
0.0
6czmE-1ipiA:
0.0		 6czmD-1ipiA:
16.29
6czmE-1ipiA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE

(Escherichia
coli) 		PF00218
(IGPS) 		5 VAL P 160
LEU P 138
GLY P 177
LEU P 176
VAL P 181
 None
 1.28A 6czmD-1jcmP:
0.0
6czmE-1jcmP:
0.0		 6czmD-1jcmP:
21.62
6czmE-1jcmP:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzl RIBOFLAVIN SYNTHASE

(Schizosaccharomyces
pombe) 		PF00677
(Lum_binding) 		5 ASN A 181
VAL A 106
GLY A  74
LEU A  73
CYH A  76
 None
 1.19A 6czmD-1kzlA:
0.0
6czmE-1kzlA:
undetectable		 6czmD-1kzlA:
18.66
6czmE-1kzlA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC

(Klebsiella
pneumoniae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 VAL A  18
VAL A 172
LEU A  21
GLY A 106
LEU A 105
 None
 1.32A 6czmD-1ozhA:
undetectable
6czmE-1ozhA:
1.4		 6czmD-1ozhA:
22.12
6czmE-1ozhA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT

(Thauera
aromatica) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		5 LEU C  25
GLY C 106
THR C  75
VAL C  51
CYH C  49
 None
None
None
None
FES  C1908 (-2.3A)
 1.31A 6czmD-1sb3C:
undetectable
6czmE-1sb3C:
undetectable		 6czmD-1sb3C:
20.18
6czmE-1sb3C:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2

(Carboxydothermus
hydrogenoformans) 		PF03063
(Prismane) 		5 VAL A 440
LEU A 470
GLY A 499
LEU A 500
VAL A 432
 None
 1.25A 6czmD-1su7A:
undetectable
6czmE-1su7A:
1.7		 6czmD-1su7A:
22.15
6czmE-1su7A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlf LAC REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		5 LEU A 177
GLY A 265
LEU A 330
THR A 287
VAL A 271
 None
 1.31A 6czmD-1tlfA:
undetectable
6czmE-1tlfA:
undetectable		 6czmD-1tlfA:
24.02
6czmE-1tlfA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ue0 ISOLEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1) 		5 VAL A 343
GLY A 356
LEU A 357
THR A 342
VAL A 351
 None
 1.13A 6czmD-1ue0A:
undetectable
6czmE-1ue0A:
undetectable		 6czmD-1ue0A:
21.51
6czmE-1ue0A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwv 23S RRNA
(URACIL-5-)-METHYLTR
ANSFERASE RUMA

(Escherichia
coli) 		PF01938
(TRAM)
PF05958
(tRNA_U5-meth_tr) 		5 LEU A 219
GLY A 181
LEU A 183
VAL A 176
CYH A 179
 None
 1.22A 6czmD-1uwvA:
undetectable
6czmE-1uwvA:
undetectable		 6czmD-1uwvA:
23.82
6czmE-1uwvA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsc HYPOTHETICAL PROTEIN
ST0229

(Sulfurisphaera
tokodaii) 		PF01871
(AMMECR1) 		5 VAL A 161
LEU A 173
GLY A 144
LEU A 145
VAL A 140
 None
 1.26A 6czmD-1wscA:
undetectable
6czmE-1wscA:
undetectable		 6czmD-1wscA:
23.27
6czmE-1wscA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB

(Mycobacterium
tuberculosis) 		PF13350
(Y_phosphatase3) 		5 VAL A  15
LEU A  22
GLY A 179
LEU A 180
VAL A 174
 None
 1.23A 6czmD-1ywfA:
undetectable
6czmE-1ywfA:
undetectable		 6czmD-1ywfA:
23.20
6czmE-1ywfA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Lactococcus
lactis) 		PF13393
(tRNA-synt_His) 		5 LEU A 172
GLY A 210
LEU A 212
THR A 231
VAL A 228
 None
 1.20A 6czmD-1z7mA:
1.5
6czmE-1z7mA:
undetectable		 6czmD-1z7mA:
23.33
6czmE-1z7mA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0n A197

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 5 VAL A 113
LEU A 118
GLY A  87
THR A 162
VAL A  84
 None
 1.19A 6czmD-2c0nA:
undetectable
6czmE-2c0nA:
undetectable		 6czmD-2c0nA:
22.73
6czmE-2c0nA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3g ALPHA-AMYLASE G-6

(Bacillus
halodurans) 		PF16738
(CBM26) 		5 VAL A  31
LEU A  22
GLY A   6
THR A  27
VAL A  60
 None
 1.17A 6czmD-2c3gA:
undetectable
6czmE-2c3gA:
undetectable		 6czmD-2c3gA:
14.46
6czmE-2c3gA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cff 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)
METHYLIDENEAMINO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Thermotoga
maritima) 		PF00977
(His_biosynth) 		5 VAL A  36
VAL A  14
LEU A  39
GLY A 223
VAL A  49
 None
 1.11A 6czmD-2cffA:
undetectable
6czmE-2cffA:
undetectable		 6czmD-2cffA:
21.81
6czmE-2cffA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cqb PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
E

(Homo sapiens) 		PF00076
(RRM_1) 		5 VAL A  52
LEU A  22
GLY A  12
LEU A  13
VAL A  79
 None
 1.23A 6czmD-2cqbA:
2.4
6czmE-2cqbA:
undetectable		 6czmD-2cqbA:
16.72
6czmE-2cqbA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eh6 ACETYLORNITHINE
AMINOTRANSFERASE

(Aquifex
aeolicus) 		PF00202
(Aminotran_3) 		5 VAL A 288
LEU A  75
GLY A 244
LEU A 243
VAL A 283
 None
 1.34A 6czmD-2eh6A:
undetectable
6czmE-2eh6A:
undetectable		 6czmD-2eh6A:
24.28
6czmE-2eh6A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fm4 PYRUVATE, PHOSPHATE
DIKINASE

([Clostridium]
symbiosum) 		PF00391
(PEP-utilizers) 		5 VAL A 427
LEU A 446
GLY A 472
LEU A 485
CYH A 471
 None
 1.33A 6czmD-2fm4A:
undetectable
6czmE-2fm4A:
undetectable		 6czmD-2fm4A:
17.20
6czmE-2fm4A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqw FERREDOXIN REDUCTASE

(Pseudomonas sp.
KKS102) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		5 VAL A 268
VAL A 274
LEU A 105
GLY A  14
LEU A  13
 None
None
None
FAD  A1449 (-3.2A)
None
 1.33A 6czmD-2gqwA:
undetectable
6czmE-2gqwA:
undetectable		 6czmD-2gqwA:
23.29
6czmE-2gqwA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  37
VAL A  82
LEU A  29
LEU A 100
THR A 164
 J60  A1305 (-4.8A)
J60  A1305 ( 4.7A)
J60  A1305 (-3.9A)
J60  A1305 (-4.4A)
J60  A1305 ( 4.4A)
 1.30A 6czmD-2jamA:
undetectable
6czmE-2jamA:
undetectable		 6czmD-2jamA:
22.05
6czmE-2jamA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o14 HYPOTHETICAL PROTEIN
YXIM

(Bacillus
subtilis) 		PF13472
(Lipase_GDSL_2) 		5 ASN A 241
LEU A 238
GLY A 208
THR A 172
VAL A 173
 None
 1.19A 6czmD-2o14A:
undetectable
6czmE-2o14A:
undetectable		 6czmD-2o14A:
21.09
6czmE-2o14A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otm HYPOTHETICAL PROTEIN

(Shewanella
oneidensis) 		PF14588
(YjgF_endoribonc) 		5 VAL A 101
LEU A  99
GLY A 114
LEU A 112
CYH A  68
 None
 1.27A 6czmD-2otmA:
undetectable
6czmE-2otmA:
undetectable		 6czmD-2otmA:
19.61
6czmE-2otmA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pn1 CARBAMOYLPHOSPHATE
SYNTHASE LARGE
SUBUNIT

(Exiguobacterium
sibiricum) 		PF02655
(ATP-grasp_3) 		5 VAL A 248
VAL A 100
GLY A  84
LEU A  83
CYH A 108
 None
 1.31A 6czmD-2pn1A:
undetectable
6czmE-2pn1A:
undetectable		 6czmD-2pn1A:
21.47
6czmE-2pn1A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3z TRANSGLUTAMINASE 2

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		5 VAL A 220
GLY A 292
LEU A 138
VAL A 287
CYH A 290
 None
 1.05A 6czmD-2q3zA:
undetectable
6czmE-2q3zA:
undetectable		 6czmD-2q3zA:
21.12
6czmE-2q3zA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vea PHYTOCHROME-LIKE
PROTEIN CPH1

(Synechocystis
sp. PCC 6803) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 VAL A 388
VAL A 422
LEU A 391
GLY A 425
LEU A 409
 None
 1.23A 6czmD-2veaA:
undetectable
6czmE-2veaA:
undetectable		 6czmD-2veaA:
22.68
6czmE-2veaA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2s MATRIX PROTEIN

(Lagos bat
lyssavirus) 		PF04785
(Rhabdo_M2) 		5 VAL A 157
LEU A 120
GLY A  98
LEU A  99
VAL A  92
 None
 1.19A 6czmD-2w2sA:
undetectable
6czmE-2w2sA:
undetectable		 6czmD-2w2sA:
21.57
6czmE-2w2sA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we8 XANTHINE
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF02625
(XdhC_CoxI)
PF13478
(XdhC_C) 		5 VAL A  43
LEU A 114
GLY A  10
LEU A   9
VAL A  15
 None
 1.09A 6czmD-2we8A:
undetectable
6czmE-2we8A:
undetectable		 6czmD-2we8A:
24.07
6czmE-2we8A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we8 XANTHINE
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF02625
(XdhC_CoxI)
PF13478
(XdhC_C) 		5 VAL A 196
VAL A 147
LEU A 181
GLY A 171
LEU A 172
 None
 0.84A 6czmD-2we8A:
undetectable
6czmE-2we8A:
undetectable		 6czmD-2we8A:
24.07
6czmE-2we8A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkp NPH1-1, RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1

(Avena sativa;
Homo sapiens) 		PF00071
(Ras)
PF13426
(PAS_9) 		5 VAL A 587
LEU A 622
GLY A 597
LEU A 598
CYH A 549
 None
 1.34A 6czmD-2wkpA:
undetectable
6czmE-2wkpA:
2.0		 6czmD-2wkpA:
22.28
6czmE-2wkpA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00344
(SecY)
PF10559
(Plug_translocon) 		5 VAL A 296
LEU A 263
GLY A 459
LEU A 289
VAL A 454
 None
 1.25A 6czmD-2ww9A:
undetectable
6czmE-2ww9A:
undetectable		 6czmD-2ww9A:
20.80
6czmE-2ww9A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsz RUVB-LIKE 1

(Homo sapiens) 		PF06068
(TIP49) 		5 VAL A 209
LEU A  38
LEU A  93
VAL A  67
CYH A  63
 None
 1.31A 6czmD-2xszA:
undetectable
6czmE-2xszA:
undetectable		 6czmD-2xszA:
22.78
6czmE-2xszA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zie PUTATIVE
MODIFICATION
METHYLASE

(Thermus
thermophilus) 		PF01555
(N6_N4_Mtase) 		5 VAL A  79
LEU A  33
GLY A 262
THR A  46
VAL A  44
 None
 1.32A 6czmD-2zieA:
undetectable
6czmE-2zieA:
undetectable		 6czmD-2zieA:
23.06
6czmE-2zieA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztu D(-)-3-HYDROXYBUTYRA
TE DEHYDROGENASE

(Pseudomonas
fragi) 		PF13561
(adh_short_C2) 		5 VAL A  57
VAL A   9
LEU A  49
GLY A  19
LEU A  18
 None
 1.17A 6czmD-2ztuA:
undetectable
6czmE-2ztuA:
undetectable		 6czmD-2ztuA:
23.24
6czmE-2ztuA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj1 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 2

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		5 VAL A 143
VAL A  77
LEU A 147
LEU A 100
THR A  51
 None
 1.09A 6czmD-3cj1A:
undetectable
6czmE-3cj1A:
undetectable		 6czmD-3cj1A:
24.63
6czmE-3cj1A:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eiq PROGRAMMED CELL
DEATH PROTEIN 4

(Mus musculus) 		PF02847
(MA3) 		5 VAL C 200
VAL C 230
LEU C 168
LEU C 191
VAL C 184
 None
 1.28A 6czmD-3eiqC:
undetectable
6czmE-3eiqC:
undetectable		 6czmD-3eiqC:
23.19
6czmE-3eiqC:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3exs RMPD
(HEXULOSE-6-PHOSPHAT
E SYNTHASE)

(Streptococcus
mutans) 		PF00215
(OMPdecase) 		5 VAL A  51
VAL A  44
LEU A  52
GLY A  37
LEU A  12
 None
 1.19A 6czmD-3exsA:
undetectable
6czmE-3exsA:
undetectable		 6czmD-3exsA:
24.25
6czmE-3exsA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF00464
(SHMT) 		5 VAL A 344
VAL A 389
LEU A  32
GLY A 384
LEU A 382
 None
 1.22A 6czmD-3g8mA:
1.8
6czmE-3g8mA:
undetectable		 6czmD-3g8mA:
23.71
6czmE-3g8mA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		5 LEU A 749
GLY A 772
LEU A 792
THR A 775
VAL A 774
 None
 1.10A 6czmD-3gsiA:
1.9
6czmE-3gsiA:
1.7		 6czmD-3gsiA:
18.65
6czmE-3gsiA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1q ETHANOLAMINE
UTILIZATION PROTEIN
EUTJ

(Carboxydothermus
hydrogenoformans) 		PF14450
(FtsA) 		5 LEU A  89
GLY A  51
LEU A  39
THR A  42
VAL A  49
 None
 1.21A 6czmD-3h1qA:
undetectable
6czmE-3h1qA:
undetectable		 6czmD-3h1qA:
24.86
6czmE-3h1qA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 4
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 5

(Thermus
thermophilus;
Thermus
thermophilus) 		PF00346
(Complex1_49kDa)
PF00329
(Complex1_30kDa) 		5 VAL 4 264
LEU 5  77
GLY 4 237
LEU 4 239
VAL 4 248
 None
 1.25A 6czmD-3i9v4:
undetectable
6czmE-3i9v4:
undetectable		 6czmD-3i9v4:
22.50
6czmE-3i9v4:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3id1 REGULATOR OF SIGMA E
PROTEASE

(Escherichia
coli) 		no annotation 5 VAL A 165
VAL A 131
LEU A 169
GLY A 214
LEU A 213
 None
 1.32A 6czmD-3id1A:
undetectable
6czmE-3id1A:
undetectable		 6czmD-3id1A:
15.69
6czmE-3id1A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7t 6-HYDROXY-L-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01593
(Amino_oxidase) 		5 VAL A 226
GLY A  13
LEU A  29
THR A 255
VAL A 253
 FAD  A 434 (-3.9A)
None
None
FAD  A 434 (-4.0A)
None
 1.30A 6czmD-3k7tA:
2.2
6czmE-3k7tA:
undetectable		 6czmD-3k7tA:
22.33
6czmE-3k7tA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3keh GLUCOCEREBROSIDASE

(Homo sapiens) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		5 VAL A 460
LEU A 444
GLY A  64
LEU A  65
THR A 482
 None
 1.11A 6czmD-3kehA:
undetectable
6czmE-3kehA:
undetectable		 6czmD-3kehA:
22.51
6czmE-3kehA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvu ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Ruegeria
pomeroyi) 		PF00496
(SBP_bac_5) 		5 VAL A 319
ASN A 321
LEU A 522
GLY A 515
LEU A 486
 None
 1.33A 6czmD-3lvuA:
undetectable
6czmE-3lvuA:
2.6		 6czmD-3lvuA:
22.03
6czmE-3lvuA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvy CARBOXYMUCONOLACTONE
DECARBOXYLASE FAMILY

(Streptococcus
mutans) 		PF02627
(CMD) 		5 VAL A  16
GLY A  36
LEU A  38
THR A  19
VAL A  23
 None
 1.30A 6czmD-3lvyA:
undetectable
6czmE-3lvyA:
undetectable		 6czmD-3lvyA:
21.23
6czmE-3lvyA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Novosphingobium
aromaticivorans) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		5 VAL A 187
LEU A 340
GLY A 193
LEU A 196
VAL A 191
 None
 1.28A 6czmD-3lxdA:
undetectable
6czmE-3lxdA:
undetectable		 6czmD-3lxdA:
21.76
6czmE-3lxdA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Yersinia pestis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 VAL A 384
VAL A 350
LEU A 385
GLY A 353
LEU A 354
 None
 1.36A 6czmD-3mjfA:
undetectable
6czmE-3mjfA:
undetectable		 6czmD-3mjfA:
24.29
6czmE-3mjfA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwt NUCLEOPROTEIN

(Lassa
mammarenavirus) 		PF00843
(Arena_nucleocap)
PF17290
(Arena_ncap_C) 		5 VAL A 199
VAL A 193
LEU A 202
LEU A 229
THR A 188
 None
 1.20A 6czmD-3mwtA:
undetectable
6czmE-3mwtA:
undetectable		 6czmD-3mwtA:
20.70
6czmE-3mwtA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvn PLEXIN-C1

(Homo sapiens) 		PF01437
(PSI) 		5 VAL B 166
LEU B 177
GLY B 126
LEU B 108
VAL B 136
 None
 1.13A 6czmD-3nvnB:
undetectable
6czmE-3nvnB:
undetectable		 6czmD-3nvnB:
23.32
6czmE-3nvnB:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE

(Taxus
canadensis) 		PF00221
(Lyase_aromatic) 		5 LEU A 331
GLY A 259
LEU A 292
VAL A 254
CYH A 258
 None
 1.34A 6czmD-3nz4A:
undetectable
6czmE-3nz4A:
undetectable		 6czmD-3nz4A:
21.68
6czmE-3nz4A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Rubrobacter
xylanophilus) 		PF00535
(Glycos_transf_2) 		5 VAL A 153
LEU A 154
GLY A  41
LEU A  40
VAL A  44
 None
 1.15A 6czmD-3o3pA:
undetectable
6czmE-3o3pA:
undetectable		 6czmD-3o3pA:
23.83
6czmE-3o3pA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm6 PUTATIVE
FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Coccidioides
immitis) 		PF01116
(F_bP_aldolase) 		5 VAL A 200
LEU A 202
LEU A 222
THR A 229
CYH A 236
 None
 1.32A 6czmD-3pm6A:
undetectable
6czmE-3pm6A:
undetectable		 6czmD-3pm6A:
21.62
6czmE-3pm6A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ruc WBGU

(Plesiomonas
shigelloides) 		PF01370
(Epimerase) 		5 VAL A  92
GLY A  45
THR A  18
VAL A  42
CYH A  73
 None
 1.01A 6czmD-3rucA:
undetectable
6czmE-3rucA:
undetectable		 6czmD-3rucA:
23.86
6czmE-3rucA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgg HYPOTHETICAL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF14323
(GxGYxYP_C)
PF16216
(GxGYxYP_N) 		5 VAL A 530
VAL A 540
GLY A 357
LEU A 356
VAL A 515
 None
 1.32A 6czmD-3sggA:
undetectable
6czmE-3sggA:
undetectable		 6czmD-3sggA:
22.30
6czmE-3sggA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5q NUCLEOPROTEIN

(Mopeia Lassa
virus
reassortant 29) 		PF00843
(Arena_nucleocap) 		5 VAL A 199
VAL A 193
LEU A 202
LEU A 229
THR A 188
 None
 1.16A 6czmD-3t5qA:
undetectable
6czmE-3t5qA:
undetectable		 6czmD-3t5qA:
23.43
6czmE-3t5qA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vre HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID

(Mammuthus
primigenius) 		PF00042
(Globin) 		5 VAL B 111
VAL B 137
LEU B 114
GLY B  72
LEU B  68
 None
 1.28A 6czmD-3vreB:
undetectable
6czmE-3vreB:
undetectable		 6czmD-3vreB:
18.18
6czmE-3vreB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wkm PUTATIVE ZINC
METALLOPROTEASE
AQ_1964

(Aquifex
aeolicus) 		PF00595
(PDZ)
PF13180
(PDZ_2) 		5 VAL A 234
VAL A 246
LEU A 259
GLY A 286
LEU A 287
 None
 1.28A 6czmD-3wkmA:
undetectable
6czmE-3wkmA:
undetectable		 6czmD-3wkmA:
23.40
6czmE-3wkmA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 LEU A  31
GLY A 123
THR A  91
VAL A  57
CYH A  55
 None
None
None
None
FES  A3002 (-2.2A)
 1.27A 6czmD-3zyvA:
undetectable
6czmE-3zyvA:
undetectable		 6czmD-3zyvA:
14.07
6czmE-3zyvA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF00111
(Fer2)
PF14574
(DUF4445) 		6 VAL X  49
VAL X  58
LEU X  48
GLY X  62
LEU X  64
THR X  79
 None
 1.38A 6czmD-3zyyX:
undetectable
6czmE-3zyyX:
undetectable		 6czmD-3zyyX:
21.98
6czmE-3zyyX:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 VAL A 100
ASN A 163
LEU A  76
GLY A 167
LEU A 168
 EDO  A1514 (-3.8A)
None
EDO  A1514 (-4.2A)
None
None
 1.18A 6czmD-4akoA:
undetectable
6czmE-4akoA:
undetectable		 6czmD-4akoA:
19.43
6czmE-4akoA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqn SPOROZOITE SURFACE
PROTEIN 2

(Plasmodium
vivax) 		PF00090
(TSP_1)
PF00092
(VWA) 		5 VAL A  49
VAL A 114
GLY A  70
LEU A  71
VAL A  64
 None
 1.17A 6czmD-4hqnA:
undetectable
6czmE-4hqnA:
undetectable		 6czmD-4hqnA:
20.56
6czmE-4hqnA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igi COLLAGEN ALPHA3(VI)

(Mus musculus) 		PF00092
(VWA) 		5 VAL A1197
LEU A1136
GLY A1192
LEU A1191
VAL A1051
 None
 1.28A 6czmD-4igiA:
undetectable
6czmE-4igiA:
undetectable		 6czmD-4igiA:
21.17
6czmE-4igiA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgu STRUCTURAL PROTEIN
VP2

(Orthopteran
ambidensovirus
1) 		PF02336
(Denso_VP4) 		5 LEU A 253
GLY A 397
LEU A 329
THR A 400
VAL A 311
 None
 1.24A 6czmD-4mguA:
undetectable
6czmE-4mguA:
undetectable		 6czmD-4mguA:
21.21
6czmE-4mguA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1

(Bos taurus) 		PF13516
(LRR_6) 		5 VAL B  99
LEU B  85
GLY B  74
LEU B  75
VAL B  68
 None
 1.22A 6czmD-4peqB:
undetectable
6czmE-4peqB:
undetectable		 6czmD-4peqB:
24.35
6czmE-4peqB:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvv ADENOSINE KINASE

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		5 VAL A 241
LEU A 307
GLY A 280
LEU A 279
VAL A 244
 None
 1.15A 6czmD-4pvvA:
undetectable
6czmE-4pvvA:
undetectable		 6czmD-4pvvA:
23.56
6czmE-4pvvA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1d UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 5 VAL A 147
ASN A 145
GLY A 135
VAL A 204
CYH A 206
 None
 1.19A 6czmD-4r1dA:
undetectable
6czmE-4r1dA:
undetectable		 6czmD-4r1dA:
21.56
6czmE-4r1dA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzo PROTEIN HTP-1
C. ELEGANS HIM-3
CLOSURE MOTIF

(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		PF02301
(HORMA)
no annotation 		5 ASN A 196
VAL A 111
LEU A  92
GLY B 280
VAL A 108
 None
 1.32A 6czmD-4tzoA:
undetectable
6czmE-4tzoA:
undetectable		 6czmD-4tzoA:
23.42
6czmE-4tzoA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ukd URIDYLMONOPHOSPHATE/
CYTIDYLMONOPHOSPHATE
KINASE

(Dictyostelium
discoideum) 		PF00406
(ADK) 		5 VAL A  71
VAL A  65
LEU A  74
GLY A  38
LEU A  40
 None
UDP  A 196 (-3.7A)
None
UDP  A 196 (-3.6A)
None
 1.11A 6czmD-4ukdA:
undetectable
6czmE-4ukdA:
undetectable		 6czmD-4ukdA:
20.44
6czmE-4ukdA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjw DUF3829 FAMILY
PROTEIN

(Bacteroides
vulgatus) 		no annotation 5 LEU A  54
GLY A 115
LEU A 117
THR A  92
VAL A  95
 None
 1.14A 6czmD-4yjwA:
undetectable
6czmE-4yjwA:
undetectable		 6czmD-4yjwA:
19.01
6czmE-4yjwA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq1 CARBONIC ANHYDRASE

(Pseudomonas
aeruginosa) 		PF00484
(Pro_CA) 		5 VAL A 104
VAL A 152
GLY A  41
VAL A  69
CYH A  42
 None
None
None
None
ZN  A 301 ( 2.2A)
 1.33A 6czmD-5bq1A:
undetectable
6czmE-5bq1A:
undetectable		 6czmD-5bq1A:
23.71
6czmE-5bq1A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dne L-ASPARAGINASE

(Cavia porcellus) 		PF00710
(Asparaginase) 		5 VAL A 264
ASN A 295
VAL A 304
GLY A 273
LEU A 312
 None
 1.34A 6czmD-5dneA:
undetectable
6czmE-5dneA:
undetectable		 6czmD-5dneA:
21.90
6czmE-5dneA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8c UL34 PROTEIN

(Suid
alphaherpesvirus
1) 		PF04541
(Herpes_U34) 		5 VAL B 139
VAL B  40
LEU B  52
GLY B  84
VAL B  73
 None
 1.15A 6czmD-5e8cB:
undetectable
6czmE-5e8cB:
undetectable		 6czmD-5e8cB:
20.99
6czmE-5e8cB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus musculus) 		PF08696
(Dna2)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 VAL A 638
VAL A 673
LEU A 639
GLY A 670
CYH A 669
 None
 1.30A 6czmD-5eawA:
undetectable
6czmE-5eawA:
undetectable		 6czmD-5eawA:
17.70
6czmE-5eawA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 LEU A  28
GLY A 120
THR A  88
VAL A  54
CYH A  52
 None
None
None
None
FES  A3002 (-2.1A)
 1.28A 6czmD-5epgA:
undetectable
6czmE-5epgA:
undetectable		 6czmD-5epgA:
14.88
6czmE-5epgA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkx UNCHARACTERIZED
PROTEIN

(Thermococcus
onnurineus) 		PF14336
(DUF4392) 		5 VAL A 204
VAL A  44
LEU A 215
GLY A  77
LEU A  76
 None
 1.18A 6czmD-5gkxA:
undetectable
6czmE-5gkxA:
0.9		 6czmD-5gkxA:
23.94
6czmE-5gkxA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5l BACTERIOPHYTOCHROME
PROTEIN

(Agrobacterium
fabrum) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 VAL A 381
VAL A 415
LEU A 384
GLY A 418
LEU A 402
 None
 1.16A 6czmD-5i5lA:
undetectable
6czmE-5i5lA:
undetectable		 6czmD-5i5lA:
22.01
6czmE-5i5lA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipf HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE (HGPRT)

(Schistosoma
mansoni) 		PF00156
(Pribosyltran) 		5 VAL A 189
VAL A 213
LEU A 170
GLY A 196
LEU A 199
 None
None
None
None
IMP  A1300 ( 4.4A)
 1.27A 6czmD-5ipfA:
undetectable
6czmE-5ipfA:
undetectable		 6czmD-5ipfA:
22.38
6czmE-5ipfA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw9 BASEPLATE WEDGE
PROTEIN GP25

(Escherichia
virus T4) 		PF04965
(GPW_gp25) 		5 VAL A 106
VAL A  81
LEU A 124
GLY A  38
LEU A  37
 None
 1.22A 6czmD-5iw9A:
undetectable
6czmE-5iw9A:
undetectable		 6czmD-5iw9A:
17.43
6czmE-5iw9A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpq ES7

(Chaetomium
thermophilum) 		PF01798
(Nop) 		5 VAL s  92
VAL s  45
LEU s  84
GLY s  20
LEU s  23
 None
 1.32A 6czmD-5jpqs:
undetectable
6czmE-5jpqs:
undetectable		 6czmD-5jpqs:
18.49
6czmE-5jpqs:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lae PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE
OXIDASE,PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE OXIDASE

(Mus musculus) 		PF01593
(Amino_oxidase) 		5 VAL A  11
VAL A 261
LEU A  36
LEU A 271
CYH A 265
 FAD  A1801 (-4.6A)
None
None
None
None
 1.32A 6czmD-5laeA:
1.3
6czmE-5laeA:
undetectable		 6czmD-5laeA:
22.95
6czmE-5laeA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum) 		PF12708
(Pectate_lyase_3) 		5 VAL A 615
LEU A 576
GLY A 534
LEU A 535
VAL A 623
 None
 0.97A 6czmD-5m60A:
undetectable
6czmE-5m60A:
undetectable		 6czmD-5m60A:
20.08
6czmE-5m60A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdn DNA POLYMERASE

(Pyrobaculum
calidifontis) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 VAL A 228
LEU A 293
GLY A 342
LEU A 343
VAL A 337
 None
 1.31A 6czmD-5mdnA:
2.9
6czmE-5mdnA:
undetectable		 6czmD-5mdnA:
19.70
6czmE-5mdnA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tbx COLD-INDUCIBLE
RNA-BINDING PROTEIN

(Homo sapiens) 		PF00076
(RRM_1) 		5 VAL A  53
LEU A  23
GLY A  13
LEU A  14
VAL A  80
 None
 1.23A 6czmD-5tbxA:
3.9
6czmE-5tbxA:
undetectable		 6czmD-5tbxA:
14.53
6czmE-5tbxA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tmh POLYPROTEIN

(Zika virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 VAL A 618
VAL A 662
LEU A 382
GLY A 505
LEU A 657
 None
 1.36A 6czmD-5tmhA:
undetectable
6czmE-5tmhA:
undetectable		 6czmD-5tmhA:
17.39
6czmE-5tmhA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u63 THIOREDOXIN
REDUCTASE

(Haemophilus
influenzae) 		PF07992
(Pyr_redox_2) 		5 VAL A 281
VAL A 287
LEU A 109
GLY A  13
LEU A  12
 None
None
None
FAD  A 401 (-3.2A)
FAD  A 401 ( 4.9A)
 1.35A 6czmD-5u63A:
undetectable
6czmE-5u63A:
undetectable		 6czmD-5u63A:
22.73
6czmE-5u63A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v36 GLUTATHIONE
REDUCTASE

(Streptococcus
mutans) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 VAL A 215
VAL A 197
LEU A 214
GLY A 176
LEU A 203
 None
None
None
SO4  A 513 ( 3.9A)
None
 1.35A 6czmD-5v36A:
undetectable
6czmE-5v36A:
undetectable		 6czmD-5v36A:
22.22
6czmE-5v36A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Acinetobacter
baumannii) 		PF00464
(SHMT) 		5 VAL A 343
VAL A 388
LEU A  31
GLY A 383
LEU A 381
 None
 1.25A 6czmD-5vmbA:
1.9
6czmE-5vmbA:
0.6		 6czmD-5vmbA:
22.81
6czmE-5vmbA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ww1 PULULLANASE

(Paenibacillus
barengoltzii) 		no annotation 5 VAL A  87
GLY A 121
LEU A 122
THR A 152
CYH A 119
 None
 1.27A 6czmD-5ww1A:
undetectable
6czmE-5ww1A:
undetectable		 6czmD-5ww1A:
undetectable
6czmE-5ww1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b67 PROTEIN PHOSPHATASE
1A

(Homo sapiens) 		no annotation 5 VAL A 254
VAL A 286
LEU A 258
LEU A 264
CYH A 290
 None
 1.19A 6czmD-6b67A:
undetectable
6czmE-6b67A:
undetectable		 6czmD-6b67A:
undetectable
6czmE-6b67A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH SUBUNIT
MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C

(Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus) 		no annotation
no annotation
no annotation
no annotation 		5 VAL F 129
VAL D  72
LEU E  79
GLY G  86
CYH G  88
 None
 1.34A 6czmD-6cfwF:
undetectable
6czmE-6cfwF:
undetectable		 6czmD-6cfwF:
undetectable
6czmE-6cfwF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czm -

(-) 		no annotation 5 GLY A 300
LEU A 301
THR A 305
VAL A 325
CYH A 327
 HIS  A 402 (-3.4A)
HIS  A 402 (-4.0A)
HIS  A 402 (-4.2A)
HIS  A 402 (-4.4A)
HIS  A 402 (-4.2A)
 0.23A 6czmD-6czmA:
41.2
6czmE-6czmA:
42.8		 6czmD-6czmA:
undetectable
6czmE-6czmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dxp -

(-) 		no annotation 5 LEU A  89
GLY A 161
LEU A 160
THR A 117
VAL A 129
 None
 1.22A 6czmD-6dxpA:
undetectable
6czmE-6dxpA:
undetectable		 6czmD-6dxpA:
undetectable
6czmE-6dxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fiv RETROPEPSIN

(Feline
immunodeficiency
virus) 		PF00077
(RVP) 		5 VAL A  20
LEU A  73
GLY A 103
LEU A 102
VAL A  89
 None
 1.10A 6czmD-6fivA:
undetectable
6czmE-6fivA:
undetectable		 6czmD-6fivA:
14.49
6czmE-6fivA:
14.49