SIMILAR PATTERNS OF AMINO ACIDS FOR 6CZM_D_HISD402

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)

(Escherichia
coli) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 LEU A  82
VAL A  41
VAL A 110
LEU A  70
 None
 0.87A 6czmD-1b0aA:
0.0
6czmF-1b0aA:
0.0		 6czmD-1b0aA:
23.14
6czmF-1b0aA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bbj IGG4-KAPPA B72.3 FAB
(LIGHT CHAIN)

(Homo sapiens;
Mus musculus) 		no annotation 4 GLY L  84
LEU L 104
VAL L  15
LEU L  78
 None
 0.73A 6czmD-1bbjL:
2.1
6czmF-1bbjL:
0.0		 6czmD-1bbjL:
23.12
6czmF-1bbjL:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwd PROTEIN
(INOSAMINE-PHOSPHATE
AMIDINOTRANSFERASE)

(Streptomyces
griseus) 		no annotation 5 GLY A  76
LEU A  75
VAL A 296
VAL A  16
LEU A 316
 None
 1.45A 6czmD-1bwdA:
0.0
6czmF-1bwdA:
0.0		 6czmD-1bwdA:
23.26
6czmF-1bwdA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3x PENTOSYLTRANSFERASE

(Cellulomonas
sp.) 		PF01048
(PNP_UDP_1) 		4 GLY A 213
LEU A 215
VAL A 194
LEU A 157
 None
 0.83A 6czmD-1c3xA:
0.0
6czmF-1c3xA:
1.0		 6czmD-1c3xA:
21.61
6czmF-1c3xA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 GLY A 102
LEU A 103
VAL A 160
LEU A 148
 None
 0.80A 6czmD-1ciyA:
0.0
6czmF-1ciyA:
0.0		 6czmD-1ciyA:
20.74
6czmF-1ciyA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pisum sativum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLY A 140
THR A  32
VAL A 336
LEU A 339
 None
 0.80A 6czmD-1dxlA:
0.0
6czmF-1dxlA:
0.0		 6czmD-1dxlA:
22.50
6czmF-1dxlA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5i DEACETOXYCEPHALOSPOR
IN C SYNTHASE

(Streptomyces
clavuligerus) 		PF03171
(2OG-FeII_Oxy) 		4 GLY A  38
LEU A  39
VAL A 224
LEU A 191
 None
 0.82A 6czmD-1e5iA:
0.0
6czmF-1e5iA:
0.0		 6czmD-1e5iA:
22.44
6czmF-1e5iA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0k UDP-N-ACETYLGLUCOSAM
INE-N-ACETYLMURAMYL-
(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Escherichia
coli) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		4 GLY A 321
VAL A 259
VAL A 184
LEU A 278
 None
 0.87A 6czmD-1f0kA:
1.0
6czmF-1f0kA:
1.3		 6czmD-1f0kA:
21.95
6czmF-1f0kA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fk1 NON-SPECIFIC LIPID
TRANSFER PROTEIN

(Zea mays) 		PF00234
(Tryp_alpha_amyl) 		4 GLY A  32
LEU A  36
VAL A  77
LEU A  53
 None
DAO  A 201 ( 4.6A)
None
None
 0.76A 6czmD-1fk1A:
undetectable
6czmF-1fk1A:
undetectable		 6czmD-1fk1A:
14.83
6czmF-1fk1A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gmm CBM6

(Ruminiclostridium
thermocellum) 		PF03422
(CBM_6) 		5 GLY A  82
LEU A  71
GLN A  70
THR A  79
LEU A 111
 None
 1.45A 6czmD-1gmmA:
0.0
6czmF-1gmmA:
undetectable		 6czmD-1gmmA:
16.01
6czmF-1gmmA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)

(Escherichia
coli) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 GLY A 353
LEU A 354
VAL A 384
VAL A 350
LEU A 385
 None
 1.34A 6czmD-1gsoA:
undetectable
6czmF-1gsoA:
undetectable		 6czmD-1gsoA:
21.13
6czmF-1gsoA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2w BETA-LACTAMASE

(Bacillus
licheniformis) 		PF13354
(Beta-lactamase2) 		4 GLY A  78
LEU A  80
GLN A  83
LEU A  91
 None
 0.78A 6czmD-1i2wA:
undetectable
6czmF-1i2wA:
undetectable		 6czmD-1i2wA:
23.34
6czmF-1i2wA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igr INSULIN-LIKE GROWTH
FACTOR RECEPTOR 1

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		4 GLY A  99
LEU A 100
VAL A 125
LEU A  87
 None
 0.72A 6czmD-1igrA:
undetectable
6czmF-1igrA:
undetectable		 6czmD-1igrA:
21.19
6czmF-1igrA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ion PROBABLE CELL
DIVISION INHIBITOR
MIND

(Pyrococcus
horikoshii) 		PF13614
(AAA_31) 		5 GLY A  86
LEU A  59
THR A  42
VAL A  93
LEU A 101
 None
 1.39A 6czmD-1ionA:
undetectable
6czmF-1ionA:
undetectable		 6czmD-1ionA:
23.68
6czmF-1ionA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipi HOLLIDAY JUNCTION
RESOLVASE

(Pyrococcus
furiosus) 		PF01870
(Hjc) 		5 GLY A 114
LEU A 113
VAL A  77
VAL A 107
LEU A  43
 None
 1.29A 6czmD-1ipiA:
undetectable
6czmF-1ipiA:
undetectable		 6czmD-1ipiA:
16.29
6czmF-1ipiA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j75 TUMOR STROMA AND
ACTIVATED MACROPHAGE
PROTEIN DLM-1

(Mus musculus) 		PF02295
(z-alpha) 		5 GLY A 132
LEU A 134
VAL A 148
VAL A 140
LEU A 149
 None
 1.35A 6czmD-1j75A:
undetectable
6czmF-1j75A:
undetectable		 6czmD-1j75A:
14.33
6czmF-1j75A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4j ACYL-HOMOSERINELACTO
NE SYNTHASE ESAI

(Pantoea
stewartii) 		PF00765
(Autoind_synth) 		5 GLY A 187
LEU A 124
GLN A 120
THR A 194
LEU A 206
 None
None
None
REO  A 405 ( 4.9A)
None
 1.16A 6czmD-1k4jA:
undetectable
6czmF-1k4jA:
undetectable		 6czmD-1k4jA:
20.06
6czmF-1k4jA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lql OSMOTICAL INDUCIBLE
PROTEIN C LIKE
FAMILY

(Mycoplasma
pneumoniae) 		PF02566
(OsmC) 		4 GLY A  89
LEU A  90
VAL A 128
LEU A  45
 None
 0.82A 6czmD-1lqlA:
3.5
6czmF-1lqlA:
3.2		 6czmD-1lqlA:
19.83
6czmF-1lqlA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltz PHENYLALANINE-4-HYDR
OXYLASE

(Chromobacterium
violaceum) 		PF00351
(Biopterin_H) 		4 LEU A  47
GLN A  51
VAL A 136
LEU A 122
 None
 0.85A 6czmD-1ltzA:
undetectable
6czmF-1ltzA:
undetectable		 6czmD-1ltzA:
21.19
6czmF-1ltzA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lu4 SOLUBLE SECRETED
ANTIGEN MPT53

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		5 GLY A1019
LEU A1022
GLN A1023
VAL A1104
LEU A1029
 None
 1.49A 6czmD-1lu4A:
undetectable
6czmF-1lu4A:
undetectable		 6czmD-1lu4A:
15.71
6czmF-1lu4A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mo2 ERYTHRONOLIDE
SYNTHASE, MODULES 5
AND 6

(Saccharopolyspora
erythraea) 		PF00975
(Thioesterase) 		4 GLY A 279
VAL A 166
VAL A  68
LEU A 226
 None
 0.81A 6czmD-1mo2A:
undetectable
6czmF-1mo2A:
undetectable		 6czmD-1mo2A:
22.44
6czmF-1mo2A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mor GLUCOSAMINE
6-PHOSPHATE SYNTHASE

(Escherichia
coli) 		PF01380
(SIS) 		4 LEU A 509
VAL A 516
VAL A 536
LEU A 468
 None
 0.84A 6czmD-1morA:
undetectable
6czmF-1morA:
undetectable		 6czmD-1morA:
24.70
6czmF-1morA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1myt MYOGLOBIN

(Thunnus
albacares) 		PF00042
(Globin) 		5 GLY A  73
LEU A  72
VAL A 112
VAL A  10
LEU A 111
 None
HEM  A 154 ( 4.8A)
None
None
None
 1.49A 6czmD-1mytA:
undetectable
6czmF-1mytA:
undetectable		 6czmD-1mytA:
19.33
6czmF-1mytA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7f AMPA RECEPTOR
INTERACTING PROTEIN
GRIP

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 GLY A 683
LEU A 682
THR A 710
VAL A 673
LEU A 748
 None
 1.11A 6czmD-1n7fA:
undetectable
6czmF-1n7fA:
undetectable		 6czmD-1n7fA:
14.33
6czmF-1n7fA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8y PROTOONCOPROTEIN

(Rattus
norvegicus) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 GLY C 433
LEU C 434
VAL C 459
LEU C 424
 None
 0.85A 6czmD-1n8yC:
undetectable
6czmF-1n8yC:
undetectable		 6czmD-1n8yC:
21.22
6czmF-1n8yC:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nlf REGULATORY PROTEIN
REPA

(Escherichia
coli) 		PF13481
(AAA_25) 		4 LEU A  50
VAL A  23
VAL A  71
LEU A  24
 None
 0.84A 6czmD-1nlfA:
undetectable
6czmF-1nlfA:
undetectable		 6czmD-1nlfA:
22.99
6czmF-1nlfA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nlr ENDO-1,4-BETA-GLUCAN
ASE

(Streptomyces
lividans) 		PF01670
(Glyco_hydro_12) 		4 GLY A   9
THR A  12
ASN A  68
VAL A  18
 None
 0.80A 6czmD-1nlrA:
undetectable
6czmF-1nlrA:
undetectable		 6czmD-1nlrA:
19.35
6czmF-1nlrA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa4 ENDO-BETA-1,4-GLUCAN
ASE

(Streptomyces
sp. 11AG8) 		PF01670
(Glyco_hydro_12) 		4 GLY A   9
THR A  12
ASN A  68
VAL A  18
 None
 0.80A 6czmD-1oa4A:
undetectable
6czmF-1oa4A:
undetectable		 6czmD-1oa4A:
20.51
6czmF-1oa4A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC

(Klebsiella
pneumoniae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 GLY A 106
LEU A 105
VAL A  18
VAL A 172
LEU A  21
 None
 1.31A 6czmD-1ozhA:
undetectable
6czmF-1ozhA:
undetectable		 6czmD-1ozhA:
22.12
6czmF-1ozhA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pc0 HYPOTHETICAL PROTEIN
AF1917

(Archaeoglobus
fulgidus) 		PF01868
(UPF0086) 		4 GLY A  52
LEU A  53
VAL A  56
VAL A  22
 None
 0.75A 6czmD-1pc0A:
undetectable
6czmF-1pc0A:
undetectable		 6czmD-1pc0A:
12.39
6czmF-1pc0A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pg5 ASPARTATE
CARBAMOYLTRANSFERASE

(Sulfolobus
acidocaldarius) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 LEU A 246
VAL A 219
VAL A 270
LEU A 155
 None
 0.86A 6czmD-1pg5A:
undetectable
6czmF-1pg5A:
undetectable		 6czmD-1pg5A:
22.16
6czmF-1pg5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Trypanosoma
brucei) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 GLY A 323
GLN A 328
VAL A 202
LEU A 206
 None
 0.82A 6czmD-1pgjA:
undetectable
6czmF-1pgjA:
undetectable		 6czmD-1pgjA:
21.19
6czmF-1pgjA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Rhodospirillum
rubrum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 GLY A  28
LEU A  29
VAL A  33
LEU A 340
 None
 0.78A 6czmD-1ptjA:
undetectable
6czmF-1ptjA:
undetectable		 6czmD-1ptjA:
22.06
6czmF-1ptjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		4 GLY A 363
VAL A 428
VAL A 332
LEU A 431
 None
 0.70A 6czmD-1pw4A:
undetectable
6czmF-1pw4A:
undetectable		 6czmD-1pw4A:
22.29
6czmF-1pw4A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyf IOLS PROTEIN

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		4 GLY A  37
LEU A  40
VAL A  70
LEU A  18
 None
 0.86A 6czmD-1pyfA:
undetectable
6czmF-1pyfA:
undetectable		 6czmD-1pyfA:
22.13
6czmF-1pyfA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3b ENDONUCLEASE VIII

(Escherichia
coli) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		4 GLY A 182
LEU A 175
GLN A 261
LEU A 197
 None
 0.86A 6czmD-1q3bA:
undetectable
6czmF-1q3bA:
undetectable		 6czmD-1q3bA:
21.98
6czmF-1q3bA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		4 GLY A 635
THR A 569
VAL A 638
LEU A 585
 None
 0.86A 6czmD-1q3xA:
undetectable
6czmF-1q3xA:
undetectable		 6czmD-1q3xA:
21.54
6czmF-1q3xA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q50 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00342
(PGI) 		4 GLY A 538
LEU A 537
VAL A 529
LEU A 400
 None
 0.76A 6czmD-1q50A:
undetectable
6czmF-1q50A:
undetectable		 6czmD-1q50A:
22.77
6czmF-1q50A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		4 LEU A 242
GLN A 279
THR A 273
VAL A 302
 None
None
NAG  A 803 (-2.6A)
None
 0.68A 6czmD-1q5aA:
undetectable
6czmF-1q5aA:
undetectable		 6czmD-1q5aA:
16.91
6czmF-1q5aA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q9j POLYKETIDE SYNTHASE
ASSOCIATED PROTEIN 5

(Mycobacterium
tuberculosis) 		PF00668
(Condensation)
PF16911
(PapA_C) 		5 GLY A 132
LEU A 122
THR A 282
VAL A  52
LEU A  53
 None
 1.36A 6czmD-1q9jA:
2.1
6czmF-1q9jA:
undetectable		 6czmD-1q9jA:
22.65
6czmF-1q9jA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcw FLAVOCYTOCHROME B2

(Saccharomyces
cerevisiae) 		PF01070
(FMN_dh) 		4 GLY A 185
LEU A 184
THR A 181
VAL A 188
 None
 0.84A 6czmD-1qcwA:
undetectable
6czmF-1qcwA:
undetectable		 6czmD-1qcwA:
24.03
6czmF-1qcwA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkv HOMOSERINE KINASE

(Pseudomonas
aeruginosa) 		PF12710
(HAD) 		4 GLY A  54
LEU A  55
VAL A 122
LEU A  29
 None
 0.84A 6czmD-1rkvA:
undetectable
6czmF-1rkvA:
undetectable		 6czmD-1rkvA:
21.39
6czmF-1rkvA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t12 NONSPECIFIC
LIPID-TRANSFER
PROTEIN 1

(Nicotiana
tabacum) 		PF00234
(Tryp_alpha_amyl) 		4 GLY A  30
LEU A  34
VAL A  75
LEU A  51
 None
 0.83A 6czmD-1t12A:
undetectable
6czmF-1t12A:
undetectable		 6czmD-1t12A:
15.19
6czmF-1t12A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Streptomyces
avermitilis) 		PF00903
(Glyoxalase) 		5 GLY A 267
GLN A 269
VAL A  26
VAL A 346
LEU A 103
 None
NTD  A 551 ( 4.2A)
None
None
None
 1.42A 6czmD-1t47A:
undetectable
6czmF-1t47A:
undetectable		 6czmD-1t47A:
24.15
6czmF-1t47A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tba TRANSCRIPTION
INITIATION FACTOR
IID 230K CHAIN
TRANSCRIPTION
INITIATION FACTOR
TFIID

(Drosophila
melanogaster;
Saccharomyces
cerevisiae) 		PF09247
(TBP-binding)
PF00352
(TBP) 		4 GLN B  68
THR B 215
VAL B 161
LEU A  52
 None
 0.87A 6czmD-1tbaB:
undetectable
6czmF-1tbaB:
undetectable		 6czmD-1tbaB:
20.11
6czmF-1tbaB:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdf THIOREDOXIN
REDUCTASE

(Escherichia
coli) 		PF07992
(Pyr_redox_2) 		5 GLY A  12
LEU A  11
VAL A 281
VAL A 287
LEU A 108
 FAD  A 500 (-3.3A)
FAD  A 500 ( 4.7A)
None
None
None
 1.42A 6czmD-1tdfA:
undetectable
6czmF-1tdfA:
undetectable		 6czmD-1tdfA:
22.85
6czmF-1tdfA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Synechococcus
elongatus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 LEU A  91
GLN A  92
VAL A  96
LEU A   6
 None
 0.73A 6czmD-1tezA:
undetectable
6czmF-1tezA:
undetectable		 6czmD-1tezA:
22.06
6czmF-1tezA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5k HYPOTHETICAL PROTEIN

(Deinococcus
radiodurans) 		PF02565
(RecO_C)
PF11967
(RecO_N) 		4 GLY A 169
THR A 150
VAL A 194
LEU A 141
 None
 0.81A 6czmD-1u5kA:
undetectable
6czmF-1u5kA:
undetectable		 6czmD-1u5kA:
23.08
6czmF-1u5kA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5v CITE

(Mycobacterium
tuberculosis) 		PF03328
(HpcH_HpaI) 		4 LEU A  56
THR A  83
VAL A  63
LEU A  33
 None
 0.70A 6czmD-1u5vA:
undetectable
6czmF-1u5vA:
undetectable		 6czmD-1u5vA:
22.65
6czmF-1u5vA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf1 KIAA1526 PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 GLY A  35
LEU A  36
VAL A  73
VAL A  87
LEU A  98
 None
 1.23A 6czmD-1uf1A:
undetectable
6czmF-1uf1A:
undetectable		 6czmD-1uf1A:
18.18
6czmF-1uf1A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uv7 GENERAL SECRETION
PATHWAY PROTEIN M

(Vibrio cholerae) 		PF04612
(T2SSM) 		4 LEU A 125
THR A  96
VAL A 115
LEU A 159
 None
 0.78A 6czmD-1uv7A:
3.0
6czmF-1uv7A:
3.0		 6czmD-1uv7A:
15.86
6czmF-1uv7A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF03710
(GlnE)
PF08335
(GlnD_UR_UTase) 		4 LEU A   8
GLN A   9
THR A  14
LEU A 400
 None
 0.81A 6czmD-1v4aA:
undetectable
6czmF-1v4aA:
undetectable		 6czmD-1v4aA:
22.30
6czmF-1v4aA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbg PYRUVATE,ORTHOPHOSPH
ATE DIKINASE

(Zea mays) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		5 GLY A  73
LEU A  74
VAL A  96
VAL A  47
LEU A  94
 None
 1.50A 6czmD-1vbgA:
undetectable
6czmF-1vbgA:
undetectable		 6czmD-1vbgA:
19.43
6czmF-1vbgA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve1 O-ACETYLSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF00291
(PALP) 		4 GLY A 177
LEU A 229
VAL A 206
LEU A 207
 PLP  A 413 (-3.8A)
None
None
None
 0.82A 6czmD-1ve1A:
undetectable
6czmF-1ve1A:
undetectable		 6czmD-1ve1A:
21.87
6czmF-1ve1A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		5 LEU A 191
GLN A 195
THR A 204
VAL A 175
LEU A 178
 None
 1.22A 6czmD-1vefA:
undetectable
6czmF-1vefA:
undetectable		 6czmD-1vefA:
22.71
6czmF-1vefA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vq7 50S RIBOSOMAL
PROTEIN L30P

(Haloarcula
marismortui) 		PF00327
(Ribosomal_L30) 		4 GLY W 124
GLN W 137
VAL W  29
VAL W 128
 U  01096 ( 3.1A)
None
G  01087 ( 4.5A)
A  01098 ( 3.7A)
 0.85A 6czmD-1vq7W:
undetectable
6czmF-1vq7W:
undetectable		 6czmD-1vq7W:
19.94
6czmF-1vq7W:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887

(Thermus
thermophilus) 		PF03641
(Lysine_decarbox) 		4 GLY A  92
LEU A  95
VAL A 127
LEU A 120
 None
 0.71A 6czmD-1wehA:
undetectable
6czmF-1wehA:
undetectable		 6czmD-1wehA:
21.33
6czmF-1wehA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887

(Thermus
thermophilus) 		PF03641
(Lysine_decarbox) 		5 GLY A 139
LEU A 140
VAL A 115
VAL A 152
LEU A 111
 None
 1.47A 6czmD-1wehA:
undetectable
6czmF-1wehA:
undetectable		 6czmD-1wehA:
21.33
6czmF-1wehA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wfm SYNAPTOTAGMIN XIII

(Homo sapiens) 		PF00168
(C2) 		5 GLY A  77
LEU A  78
GLN A  62
VAL A  52
LEU A  92
 None
 1.49A 6czmD-1wfmA:
undetectable
6czmF-1wfmA:
undetectable		 6czmD-1wfmA:
19.88
6czmF-1wfmA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wle SERYL-TRNA
SYNTHETASE

(Bos taurus) 		PF00587
(tRNA-synt_2b) 		5 LEU A 362
GLN A 358
THR A 229
VAL A 440
LEU A 443
 None
 1.41A 6czmD-1wleA:
undetectable
6czmF-1wleA:
undetectable		 6czmD-1wleA:
23.65
6czmF-1wleA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa0 PUTATIVE NADPH
DEPENDENT
OXIDOREDUCTASES

(Geobacillus
stearothermophilus) 		PF00107
(ADH_zinc_N) 		4 GLY A 269
LEU A 267
VAL A 232
LEU A 229
 None
 0.86A 6czmD-1xa0A:
undetectable
6czmF-1xa0A:
undetectable		 6czmD-1xa0A:
25.00
6czmF-1xa0A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y5e MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B

(Bacillus cereus) 		PF00994
(MoCF_biosynth) 		5 GLY A  67
THR A  78
VAL A  94
VAL A  19
LEU A  97
 None
 1.35A 6czmD-1y5eA:
undetectable
6czmF-1y5eA:
undetectable		 6czmD-1y5eA:
20.87
6czmF-1y5eA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr1 CELL-DIVISION
INITIATION PROTEIN

(Geobacillus
stearothermophilus) 		no annotation 4 GLY A 169
LEU A 171
VAL A 124
LEU A 155
 None
 0.73A 6czmD-1yr1A:
undetectable
6czmF-1yr1A:
undetectable		 6czmD-1yr1A:
16.81
6czmF-1yr1A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbr CONSERVED
HYPOTHETICAL PROTEIN

(Porphyromonas
gingivalis) 		PF04371
(PAD_porph) 		4 GLY A 306
LEU A 307
VAL A 287
LEU A 260
 None
 0.86A 6czmD-1zbrA:
undetectable
6czmF-1zbrA:
undetectable		 6czmD-1zbrA:
22.83
6czmF-1zbrA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbs HYPOTHETICAL PROTEIN
PG1100

(Porphyromonas
gingivalis) 		PF01869
(BcrAD_BadFG) 		4 GLY A 260
LEU A 261
VAL A 225
LEU A 229
 None
 0.84A 6czmD-1zbsA:
undetectable
6czmF-1zbsA:
undetectable		 6czmD-1zbsA:
24.75
6czmF-1zbsA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		4 GLY A 635
THR A 569
VAL A 638
LEU A 585
 None
 0.85A 6czmD-1zjkA:
undetectable
6czmF-1zjkA:
undetectable		 6czmD-1zjkA:
21.43
6czmF-1zjkA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zmb ACETYLXYLAN ESTERASE
RELATED ENZYME

(Clostridium
acetobutylicum) 		PF03629
(SASA) 		4 GLY A 156
LEU A 181
GLN A 182
LEU A 135
 None
 0.75A 6czmD-1zmbA:
undetectable
6czmF-1zmbA:
undetectable		 6czmD-1zmbA:
20.85
6czmF-1zmbA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4f TISSUE FACTOR
PRECURSOR

(Homo sapiens) 		PF09294
(Interfer-bind) 		4 GLY U 109
LEU U 108
THR U 132
LEU U 151
 None
 0.80A 6czmD-2c4fU:
undetectable
6czmF-2c4fU:
undetectable		 6czmD-2c4fU:
18.37
6czmF-2c4fU:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cda GLUCOSE
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF08240
(ADH_N)
PF16912
(Glu_dehyd_C) 		4 GLY A 204
LEU A 205
THR A 228
VAL A 186
 None
 0.83A 6czmD-2cdaA:
undetectable
6czmF-2cdaA:
undetectable		 6czmD-2cdaA:
22.52
6czmF-2cdaA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csw UBIQUITIN LIGASE
PROTEIN RNF8

(Homo sapiens) 		PF00498
(FHA) 		5 LEU A  50
GLN A  49
THR A  39
VAL A  46
LEU A 108
 None
 1.28A 6czmD-2cswA:
undetectable
6czmF-2cswA:
undetectable		 6czmD-2cswA:
16.48
6czmF-2cswA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4v ISOCITRATE
DEHYDROGENASE

(Acidithiobacillus
thiooxidans) 		PF00180
(Iso_dh) 		4 GLN A 301
VAL A 322
VAL A 293
LEU A 326
 None
 0.77A 6czmD-2d4vA:
undetectable
6czmF-2d4vA:
undetectable		 6czmD-2d4vA:
24.26
6czmF-2d4vA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7

(Homo sapiens) 		PF04857
(CAF1) 		4 GLY A  78
LEU A  79
VAL A  15
LEU A 140
 None
 0.76A 6czmD-2d5rA:
undetectable
6czmF-2d5rA:
undetectable		 6czmD-2d5rA:
22.10
6czmF-2d5rA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		4 GLY A 154
VAL A 194
VAL A  89
LEU A 192
 None
 0.60A 6czmD-2d62A:
undetectable
6czmF-2d62A:
undetectable		 6czmD-2d62A:
22.66
6czmF-2d62A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7u ADENYLOSUCCINATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00709
(Adenylsucc_synt) 		4 GLY A  17
VAL A   4
VAL A 220
LEU A 174
 None
 0.84A 6czmD-2d7uA:
undetectable
6czmF-2d7uA:
undetectable		 6czmD-2d7uA:
22.19
6czmF-2d7uA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		4 GLY A 237
LEU A 266
THR A 270
LEU A 279
 None
 0.80A 6czmD-2dh4A:
undetectable
6czmF-2dh4A:
undetectable		 6czmD-2dh4A:
21.97
6czmF-2dh4A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 GLY A 182
GLN A 178
THR A 240
VAL A 300
 None
 0.83A 6czmD-2ep5A:
1.3
6czmF-2ep5A:
1.2		 6czmD-2ep5A:
22.19
6czmF-2ep5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7l 455AA LONG
HYPOTHETICAL
PHOSPHO-SUGAR MUTASE

(Sulfurisphaera
tokodaii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 GLY A 196
LEU A 195
VAL A 156
LEU A 160
 None
 0.85A 6czmD-2f7lA:
undetectable
6czmF-2f7lA:
undetectable		 6czmD-2f7lA:
24.03
6czmF-2f7lA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fa0 HMG-COA SYNTHASE

(Brassica juncea) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 GLY A 141
LEU A 142
VAL A 108
LEU A  65
 None
 0.85A 6czmD-2fa0A:
0.8
6czmF-2fa0A:
0.6		 6czmD-2fa0A:
23.16
6czmF-2fa0A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0t CONSERVED
HYPOTHETICAL PROTEIN

(Thermotoga
maritima) 		PF07755
(DUF1611)
PF17396
(DUF1611_N) 		5 GLY A 198
LEU A 200
GLN A 196
VAL A 208
LEU A   3
 None
 1.44A 6czmD-2g0tA:
undetectable
6czmF-2g0tA:
undetectable		 6czmD-2g0tA:
24.21
6czmF-2g0tA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g17 N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Salmonella
enterica) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 GLY A  14
LEU A  17
THR A  33
VAL A  76
 None
 0.86A 6czmD-2g17A:
0.7
6czmF-2g17A:
1.0		 6czmD-2g17A:
23.74
6czmF-2g17A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 GLY A 138
LEU A 139
VAL A  60
LEU A  61
 None
 0.77A 6czmD-2gjxA:
undetectable
6czmF-2gjxA:
undetectable		 6czmD-2gjxA:
21.07
6czmF-2gjxA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
BETA-HEXOSAMINIDASE
SUBUNIT ALPHA

(Homo sapiens;
Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2)
no annotation 		4 GLY I 138
LEU I 139
VAL A  60
LEU A  61
 None
 0.69A 6czmD-2gk1I:
undetectable
6czmF-2gk1I:
undetectable		 6czmD-2gk1I:
20.97
6czmF-2gk1I:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqw FERREDOXIN REDUCTASE

(Pseudomonas sp.
KKS102) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		5 GLY A  14
LEU A  13
VAL A 268
VAL A 274
LEU A 105
 FAD  A1449 (-3.2A)
None
None
None
None
 1.36A 6czmD-2gqwA:
undetectable
6czmF-2gqwA:
undetectable		 6czmD-2gqwA:
23.29
6czmF-2gqwA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gu9 TETRACENOMYCIN
POLYKETIDE SYNTHESIS
PROTEIN

(Xanthomonas
campestris) 		PF07883
(Cupin_2) 		4 GLY A  55
LEU A  66
GLN A  67
LEU A  48
 None
 0.82A 6czmD-2gu9A:
undetectable
6czmF-2gu9A:
undetectable		 6czmD-2gu9A:
17.33
6czmF-2gu9A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gvk HEME PEROXIDASE

(Bacteroides
thetaiotaomicron) 		PF04261
(Dyp_perox) 		4 GLY A  69
THR A 301
VAL A 138
VAL A 189
 None
EDO  A 322 (-3.6A)
None
None
 0.82A 6czmD-2gvkA:
1.0
6czmF-2gvkA:
undetectable		 6czmD-2gvkA:
23.22
6czmF-2gvkA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 GLY A 461
LEU A 460
GLN A 422
VAL A 244
LEU A 243
 None
None
DU  A 611 (-4.0A)
None
None
 1.42A 6czmD-2h2qA:
undetectable
6czmF-2h2qA:
undetectable		 6czmD-2h2qA:
20.00
6czmF-2h2qA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h92 CYTIDYLATE KINASE

(Staphylococcus
aureus) 		PF02224
(Cytidylate_kin) 		4 LEU A  41
VAL A  82
VAL A  91
LEU A  77
 None
 0.84A 6czmD-2h92A:
undetectable
6czmF-2h92A:
undetectable		 6czmD-2h92A:
21.19
6czmF-2h92A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hiq HYPOTHETICAL PROTEIN
YDHR

(Escherichia
coli) 		PF08803
(ydhR) 		4 GLY A  59
LEU A  14
VAL A  85
LEU A  80
 None
 0.78A 6czmD-2hiqA:
4.5
6czmF-2hiqA:
4.4		 6czmD-2hiqA:
15.58
6czmF-2hiqA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ig2 IGG1-LAMBDA KOL FAB
(HEAVY CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H 195
LEU H 194
VAL H 187
LEU H 143
 None
 0.83A 6czmD-2ig2H:
2.1
6czmF-2ig2H:
undetectable		 6czmD-2ig2H:
21.80
6czmF-2ig2H:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Arabidopsis
thaliana) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLY A  61
THR A  51
VAL A 397
LEU A 390
 None
 0.84A 6czmD-2ix4A:
undetectable
6czmF-2ix4A:
undetectable		 6czmD-2ix4A:
24.31
6czmF-2ix4A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		4 GLY A1943
LEU A1692
GLN A1662
VAL A1666
 None
 0.70A 6czmD-2ix8A:
undetectable
6czmF-2ix8A:
undetectable		 6czmD-2ix8A:
16.50
6czmF-2ix8A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy9 SUBA

(Escherichia
coli) 		PF00082
(Peptidase_S8) 		4 GLY A 318
LEU A 311
VAL A 247
LEU A 221
 None
 0.74A 6czmD-2iy9A:
undetectable
6czmF-2iy9A:
undetectable		 6czmD-2iy9A:
23.28
6czmF-2iy9A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 100
THR A 164
VAL A  37
VAL A  82
LEU A  29
 J60  A1305 (-4.4A)
J60  A1305 ( 4.4A)
J60  A1305 (-4.8A)
J60  A1305 ( 4.7A)
J60  A1305 (-3.9A)
 1.28A 6czmD-2jamA:
undetectable
6czmF-2jamA:
undetectable		 6czmD-2jamA:
22.05
6czmF-2jamA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kk1 TYROSINE-PROTEIN
KINASE ABL2

(Homo sapiens) 		PF08919
(F_actin_bind) 		5 GLY A 114
LEU A 119
VAL A  63
VAL A  57
LEU A 103
 None
 1.43A 6czmD-2kk1A:
undetectable
6czmF-2kk1A:
undetectable		 6czmD-2kk1A:
16.33
6czmF-2kk1A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kyz HEAVY METAL BINDING
PROTEIN

(Thermotoga
maritima) 		PF00403
(HMA) 		4 LEU A  47
VAL A  40
VAL A  28
LEU A   5
 None
 0.85A 6czmD-2kyzA:
5.5
6czmF-2kyzA:
5.4		 6czmD-2kyzA:
12.17
6czmF-2kyzA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l8b PROTEIN TRAI

(Escherichia
coli) 		no annotation 5 LEU A 426
THR A 535
VAL A 449
VAL A 436
LEU A 452
 None
 1.48A 6czmD-2l8bA:
undetectable
6czmF-2l8bA:
undetectable		 6czmD-2l8bA:
19.89
6czmF-2l8bA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 LEU A 577
VAL A 587
VAL A 621
LEU A 541
 None
 0.75A 6czmD-2nq5A:
undetectable
6czmF-2nq5A:
undetectable		 6czmD-2nq5A:
19.60
6czmF-2nq5A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		4 GLY A 137
LEU A 138
VAL A 142
LEU A 100
 None
 0.77A 6czmD-2o4cA:
undetectable
6czmF-2o4cA:
undetectable		 6czmD-2o4cA:
23.80
6czmF-2o4cA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6r VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13855
(LRR_8) 		4 LEU A 111
GLN A 134
VAL A 138
LEU A 114
 None
 0.78A 6czmD-2o6rA:
undetectable
6czmF-2o6rA:
undetectable		 6czmD-2o6rA:
20.96
6czmF-2o6rA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2or0 HYDROXYLASE

(Rhodococcus
jostii) 		PF08028
(Acyl-CoA_dh_2) 		5 GLY A 236
LEU A 235
THR A  63
VAL A  55
LEU A  45
 None
 1.49A 6czmD-2or0A:
undetectable
6czmF-2or0A:
undetectable		 6czmD-2or0A:
22.74
6czmF-2or0A:
22.74