SIMILAR PATTERNS OF AMINO ACIDS FOR 6CZM_C_HISC402_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)

(Paracoccus
denitrificans) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 VAL A 301
LEU A 304
GLY A 292
LEU A 293
VAL A 254
 None
 1.11A 6czmB-1efpA:
0.0
6czmC-1efpA:
0.4		 6czmB-1efpA:
24.54
6czmC-1efpA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE F

(Bacillus
subtilis) 		PF00072
(Response_reg) 		5 VAL E1243
VAL E1278
LEU E1240
GLY E1262
VAL E1209
 None
 1.22A 6czmB-1f51E:
1.5
6czmC-1f51E:
0.3		 6czmB-1f51E:
16.43
6czmC-1f51E:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iok CHAPERONIN 60

(Paracoccus
denitrificans) 		PF00118
(Cpn60_TCP1) 		5 VAL A  77
VAL A 100
GLY A  19
LEU A  23
GLN A  97
 None
 1.22A 6czmB-1iokA:
1.2
6czmC-1iokA:
0.0		 6czmB-1iokA:
25.00
6czmC-1iokA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipi HOLLIDAY JUNCTION
RESOLVASE

(Pyrococcus
furiosus) 		PF01870
(Hjc) 		5 VAL A  77
VAL A 107
LEU A  43
GLY A 114
LEU A 113
 None
 1.31A 6czmB-1ipiA:
0.0
6czmC-1ipiA:
undetectable		 6czmB-1ipiA:
16.29
6czmC-1ipiA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE

(Escherichia
coli) 		PF00218
(IGPS) 		5 VAL P 160
LEU P 138
GLY P 177
LEU P 176
VAL P 181
 None
 1.28A 6czmB-1jcmP:
0.0
6czmC-1jcmP:
0.0		 6czmB-1jcmP:
21.62
6czmC-1jcmP:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51

(Saimiri
boliviensis) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8) 		5 VAL A  55
VAL A  86
GLY A  82
GLN A  85
VAL A  94
 None
 1.31A 6czmB-1kt1A:
0.0
6czmC-1kt1A:
0.0		 6czmB-1kt1A:
23.11
6czmC-1kt1A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kz1 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

(Schizosaccharomyces
pombe) 		PF00885
(DMRL_synthase) 		5 VAL A 117
LEU A 106
GLY A  85
LEU A 121
VAL A  23
 None
 1.11A 6czmB-1kz1A:
1.5
6czmC-1kz1A:
1.7		 6czmB-1kz1A:
21.09
6czmC-1kz1A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC

(Klebsiella
pneumoniae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 VAL A  18
VAL A 172
LEU A  21
GLY A 106
LEU A 105
 None
 1.35A 6czmB-1ozhA:
1.3
6czmC-1ozhA:
0.0		 6czmB-1ozhA:
22.12
6czmC-1ozhA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpw PORCINE HEMOGLOBIN
(BETA SUBUNIT)

(Sus scrofa) 		PF00042
(Globin) 		5 VAL B  23
VAL B 112
LEU B  68
GLY B 107
LEU B 106
 None
None
None
None
HEM  B 750 (-4.3A)
 1.26A 6czmB-1qpwB:
undetectable
6czmC-1qpwB:
undetectable		 6czmB-1qpwB:
18.80
6czmC-1qpwB:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlf LAC REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		5 LEU A 177
GLY A 265
LEU A 330
THR A 287
VAL A 271
 None
 1.29A 6czmB-1tlfA:
1.0
6czmC-1tlfA:
0.5		 6czmB-1tlfA:
24.02
6czmC-1tlfA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ue0 ISOLEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1) 		5 VAL A 343
GLY A 356
LEU A 357
THR A 342
VAL A 351
 None
 1.13A 6czmB-1ue0A:
undetectable
6czmC-1ue0A:
undetectable		 6czmB-1ue0A:
21.51
6czmC-1ue0A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umf CHORISMATE SYNTHASE

(Helicobacter
pylori) 		PF01264
(Chorismate_synt) 		5 LEU A 343
GLY A 220
LEU A 221
GLN A 223
VAL A 279
 None
 1.27A 6czmB-1umfA:
2.0
6czmC-1umfA:
undetectable		 6czmB-1umfA:
24.51
6czmC-1umfA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		5 VAL A 175
LEU A 178
LEU A 191
GLN A 195
THR A 204
 None
 1.26A 6czmB-1vefA:
undetectable
6czmC-1vefA:
undetectable		 6czmB-1vefA:
22.71
6czmC-1vefA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdi RV3303C-LPDA

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 294
LEU A 293
GLN A 292
THR A 307
VAL A 301
 None
 1.22A 6czmB-1xdiA:
undetectable
6czmC-1xdiA:
undetectable		 6czmB-1xdiA:
21.50
6czmC-1xdiA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y5e MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B

(Bacillus cereus) 		PF00994
(MoCF_biosynth) 		5 VAL A  94
VAL A  19
LEU A  97
GLY A  67
THR A  78
 None
 1.36A 6czmB-1y5eA:
undetectable
6czmC-1y5eA:
1.5		 6czmB-1y5eA:
20.87
6czmC-1y5eA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0n A197

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 5 VAL A 113
LEU A 118
GLY A  87
THR A 162
VAL A  84
 None
 1.20A 6czmB-2c0nA:
undetectable
6czmC-2c0nA:
undetectable		 6czmB-2c0nA:
22.73
6czmC-2c0nA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3g ALPHA-AMYLASE G-6

(Bacillus
halodurans) 		PF16738
(CBM26) 		5 VAL A  31
LEU A  22
GLY A   6
THR A  27
VAL A  60
 None
 1.18A 6czmB-2c3gA:
undetectable
6czmC-2c3gA:
undetectable		 6czmB-2c3gA:
14.46
6czmC-2c3gA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cff 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)
METHYLIDENEAMINO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Thermotoga
maritima) 		PF00977
(His_biosynth) 		5 VAL A  36
VAL A  14
LEU A  39
GLY A 223
VAL A  49
 None
 1.10A 6czmB-2cffA:
undetectable
6czmC-2cffA:
undetectable		 6czmB-2cffA:
21.81
6czmC-2cffA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csw UBIQUITIN LIGASE
PROTEIN RNF8

(Homo sapiens) 		PF00498
(FHA) 		5 VAL A  46
LEU A 108
LEU A  50
GLN A  49
THR A  39
 None
 1.32A 6czmB-2cswA:
undetectable
6czmC-2cswA:
undetectable		 6czmB-2cswA:
16.48
6czmC-2cswA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4v ISOCITRATE
DEHYDROGENASE

(Acidithiobacillus
thiooxidans) 		PF00180
(Iso_dh) 		5 VAL A 322
VAL A 293
LEU A 326
GLN A 301
VAL A 312
 None
 0.98A 6czmB-2d4vA:
undetectable
6czmC-2d4vA:
1.7		 6czmB-2d4vA:
24.26
6czmC-2d4vA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eh6 ACETYLORNITHINE
AMINOTRANSFERASE

(Aquifex
aeolicus) 		PF00202
(Aminotran_3) 		5 VAL A 288
LEU A  75
GLY A 244
LEU A 243
VAL A 283
 None
 1.34A 6czmB-2eh6A:
undetectable
6czmC-2eh6A:
undetectable		 6czmB-2eh6A:
24.28
6czmC-2eh6A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho1 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILF

(Pseudomonas
aeruginosa) 		PF13414
(TPR_11)
PF13424
(TPR_12) 		5 LEU A  60
LEU A  45
GLN A  49
THR A  53
VAL A  80
 None
 1.32A 6czmB-2ho1A:
undetectable
6czmC-2ho1A:
undetectable		 6czmB-2ho1A:
22.60
6czmC-2ho1A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivx CYCLIN-T2

(Homo sapiens) 		PF00134
(Cyclin_N) 		5 VAL A 198
LEU A 202
LEU A 241
GLN A 242
THR A 184
 None
 1.27A 6czmB-2ivxA:
undetectable
6czmC-2ivxA:
undetectable		 6czmB-2ivxA:
22.37
6czmC-2ivxA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  37
VAL A  82
LEU A  29
LEU A 100
THR A 164
 J60  A1305 (-4.8A)
J60  A1305 ( 4.7A)
J60  A1305 (-3.9A)
J60  A1305 (-4.4A)
J60  A1305 ( 4.4A)
 1.30A 6czmB-2jamA:
undetectable
6czmC-2jamA:
undetectable		 6czmB-2jamA:
22.05
6czmC-2jamA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l7n TALIN-1

(Mus musculus) 		no annotation 5 VAL A1192
VAL A1057
LEU A1196
LEU A1131
VAL A1124
 None
 1.21A 6czmB-2l7nA:
undetectable
6czmC-2l7nA:
undetectable		 6czmB-2l7nA:
21.86
6czmC-2l7nA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mii PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOB

(Escherichia
coli) 		PF13036
(LpoB) 		5 VAL A  89
LEU A 109
GLY A 190
GLN A 177
VAL A  72
 None
 1.12A 6czmB-2miiA:
undetectable
6czmC-2miiA:
undetectable		 6czmB-2miiA:
20.73
6czmC-2miiA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o14 HYPOTHETICAL PROTEIN
YXIM

(Bacillus
subtilis) 		PF13472
(Lipase_GDSL_2) 		5 ASN A 241
LEU A 238
GLY A 208
THR A 172
VAL A 173
 None
 1.17A 6czmB-2o14A:
undetectable
6czmC-2o14A:
undetectable		 6czmB-2o14A:
21.09
6czmC-2o14A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vea PHYTOCHROME-LIKE
PROTEIN CPH1

(Synechocystis
sp. PCC 6803) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 VAL A 388
VAL A 422
LEU A 391
GLY A 425
LEU A 409
 None
 1.23A 6czmB-2veaA:
undetectable
6czmC-2veaA:
undetectable		 6czmB-2veaA:
22.68
6czmC-2veaA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2s MATRIX PROTEIN

(Lagos bat
lyssavirus) 		PF04785
(Rhabdo_M2) 		5 VAL A 157
LEU A 120
GLY A  98
LEU A  99
VAL A  92
 None
 1.21A 6czmB-2w2sA:
undetectable
6czmC-2w2sA:
undetectable		 6czmB-2w2sA:
21.57
6czmC-2w2sA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we8 XANTHINE
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF02625
(XdhC_CoxI)
PF13478
(XdhC_C) 		5 VAL A  43
LEU A 114
GLY A  10
LEU A   9
VAL A  15
 None
 1.07A 6czmB-2we8A:
undetectable
6czmC-2we8A:
undetectable		 6czmB-2we8A:
24.07
6czmC-2we8A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we8 XANTHINE
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF02625
(XdhC_CoxI)
PF13478
(XdhC_C) 		5 VAL A 196
VAL A 147
LEU A 181
GLY A 171
LEU A 172
 None
 0.86A 6czmB-2we8A:
undetectable
6czmC-2we8A:
undetectable		 6czmB-2we8A:
24.07
6czmC-2we8A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00344
(SecY)
PF10559
(Plug_translocon) 		5 VAL A 296
LEU A 263
GLY A 459
LEU A 289
VAL A 454
 None
 1.29A 6czmB-2ww9A:
undetectable
6czmC-2ww9A:
undetectable		 6czmB-2ww9A:
20.80
6czmC-2ww9A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0s PROBABLE EXOSOME
COMPLEX RNA-BINDING
PROTEIN 1

(Aeropyrum
pernix) 		PF15985
(KH_6) 		5 LEU A 114
GLY A 101
LEU A 100
GLN A  97
VAL A 138
 None
 1.06A 6czmB-2z0sA:
undetectable
6czmC-2z0sA:
undetectable		 6czmB-2z0sA:
24.77
6czmC-2z0sA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zie PUTATIVE
MODIFICATION
METHYLASE

(Thermus
thermophilus) 		PF01555
(N6_N4_Mtase) 		5 VAL A  79
LEU A  33
GLY A 262
THR A  46
VAL A  44
 None
 1.31A 6czmB-2zieA:
undetectable
6czmC-2zieA:
undetectable		 6czmB-2zieA:
23.06
6czmC-2zieA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztu D(-)-3-HYDROXYBUTYRA
TE DEHYDROGENASE

(Pseudomonas
fragi) 		PF13561
(adh_short_C2) 		5 VAL A  57
VAL A   9
LEU A  49
GLY A  19
LEU A  18
 None
 1.16A 6czmB-2ztuA:
undetectable
6czmC-2ztuA:
undetectable		 6czmB-2ztuA:
23.24
6czmC-2ztuA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3awd PUTATIVE POLYOL
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF13561
(adh_short_C2) 		5 VAL A  51
LEU A  54
GLY A  23
LEU A  24
GLN A  20
 None
 1.19A 6czmB-3awdA:
undetectable
6czmC-3awdA:
undetectable		 6czmB-3awdA:
23.70
6czmC-3awdA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc8 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Mus musculus) 		PF05889
(SepSecS) 		5 LEU A 454
GLY A 392
LEU A 391
GLN A 390
VAL A 400
 None
 1.27A 6czmB-3bc8A:
0.9
6czmC-3bc8A:
undetectable		 6czmB-3bc8A:
20.80
6czmC-3bc8A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzj UV ENDONUCLEASE

(Thermus
thermophilus) 		PF03851
(UvdE) 		5 VAL A 159
VAL A 186
LEU A 162
LEU A 142
VAL A 195
 None
 1.24A 6czmB-3bzjA:
undetectable
6czmC-3bzjA:
undetectable		 6czmB-3bzjA:
24.87
6czmC-3bzjA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj1 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 2

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		5 VAL A 143
VAL A  77
LEU A 147
LEU A 100
THR A  51
 None
 1.12A 6czmB-3cj1A:
undetectable
6czmC-3cj1A:
undetectable		 6czmB-3cj1A:
24.63
6czmC-3cj1A:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eiq PROGRAMMED CELL
DEATH PROTEIN 4

(Mus musculus) 		PF02847
(MA3) 		5 VAL C 200
VAL C 230
LEU C 168
LEU C 191
VAL C 184
 None
 1.28A 6czmB-3eiqC:
undetectable
6czmC-3eiqC:
undetectable		 6czmB-3eiqC:
23.19
6czmC-3eiqC:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3exs RMPD
(HEXULOSE-6-PHOSPHAT
E SYNTHASE)

(Streptococcus
mutans) 		PF00215
(OMPdecase) 		5 VAL A  51
VAL A  44
LEU A  52
GLY A  37
LEU A  12
 None
 1.20A 6czmB-3exsA:
undetectable
6czmC-3exsA:
undetectable		 6czmB-3exsA:
24.25
6czmC-3exsA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		5 VAL A 486
LEU A 497
GLY A 502
GLN A 539
THR A 521
 None
None
None
CL  A 916 (-3.6A)
None
 1.20A 6czmB-3fahA:
undetectable
6czmC-3fahA:
undetectable		 6czmB-3fahA:
19.14
6czmC-3fahA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF00464
(SHMT) 		5 VAL A 344
VAL A 389
LEU A  32
GLY A 384
LEU A 382
 None
 1.27A 6czmB-3g8mA:
1.8
6czmC-3g8mA:
undetectable		 6czmB-3g8mA:
23.71
6czmC-3g8mA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		5 LEU A 749
GLY A 772
LEU A 792
THR A 775
VAL A 774
 None
 1.13A 6czmB-3gsiA:
2.3
6czmC-3gsiA:
2.1		 6czmB-3gsiA:
18.65
6czmC-3gsiA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1q ETHANOLAMINE
UTILIZATION PROTEIN
EUTJ

(Carboxydothermus
hydrogenoformans) 		PF14450
(FtsA) 		5 LEU A  89
GLY A  51
LEU A  39
THR A  42
VAL A  49
 None
 1.22A 6czmB-3h1qA:
undetectable
6czmC-3h1qA:
undetectable		 6czmB-3h1qA:
24.86
6czmC-3h1qA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 4
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 5

(Thermus
thermophilus;
Thermus
thermophilus) 		PF00346
(Complex1_49kDa)
PF00329
(Complex1_30kDa) 		5 VAL 4 264
LEU 5  77
GLY 4 237
LEU 4 239
VAL 4 248
 None
 1.26A 6czmB-3i9v4:
undetectable
6czmC-3i9v4:
undetectable		 6czmB-3i9v4:
22.50
6czmC-3i9v4:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7t 6-HYDROXY-L-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01593
(Amino_oxidase) 		5 VAL A 226
GLY A  13
LEU A  29
THR A 255
VAL A 253
 FAD  A 434 (-3.9A)
None
None
FAD  A 434 (-4.0A)
None
 1.30A 6czmB-3k7tA:
2.2
6czmC-3k7tA:
undetectable		 6czmB-3k7tA:
22.33
6czmC-3k7tA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvu ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Ruegeria
pomeroyi) 		PF00496
(SBP_bac_5) 		5 VAL A 319
ASN A 321
LEU A 522
GLY A 515
LEU A 486
 None
 1.34A 6czmB-3lvuA:
undetectable
6czmC-3lvuA:
1.1		 6czmB-3lvuA:
22.03
6czmC-3lvuA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvy CARBOXYMUCONOLACTONE
DECARBOXYLASE FAMILY

(Streptococcus
mutans) 		PF02627
(CMD) 		5 VAL A  16
GLY A  36
LEU A  38
THR A  19
VAL A  23
 None
 1.31A 6czmB-3lvyA:
undetectable
6czmC-3lvyA:
undetectable		 6czmB-3lvyA:
21.23
6czmC-3lvyA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Novosphingobium
aromaticivorans) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		5 VAL A 187
LEU A 340
GLY A 193
LEU A 196
VAL A 191
 None
 1.31A 6czmB-3lxdA:
undetectable
6czmC-3lxdA:
undetectable		 6czmB-3lxdA:
21.76
6czmC-3lxdA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwt NUCLEOPROTEIN

(Lassa
mammarenavirus) 		PF00843
(Arena_nucleocap)
PF17290
(Arena_ncap_C) 		5 VAL A 199
VAL A 193
LEU A 202
LEU A 229
THR A 188
 None
 1.19A 6czmB-3mwtA:
undetectable
6czmC-3mwtA:
undetectable		 6czmB-3mwtA:
20.70
6czmC-3mwtA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 VAL B 557
VAL B 665
GLY B 594
LEU B 552
THR B 679
 None
 1.34A 6czmB-3pcoB:
2.6
6czmC-3pcoB:
3.5		 6czmB-3pcoB:
17.63
6czmC-3pcoB:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qye TBC1 DOMAIN FAMILY
MEMBER 1

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		5 VAL A1045
LEU A1030
GLY A1007
LEU A1006
THR A1041
 None
 1.35A 6czmB-3qyeA:
undetectable
6czmC-3qyeA:
undetectable		 6czmB-3qyeA:
23.33
6czmC-3qyeA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgg HYPOTHETICAL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF14323
(GxGYxYP_C)
PF16216
(GxGYxYP_N) 		5 VAL A 530
VAL A 540
GLY A 357
LEU A 356
VAL A 515
 None
 1.28A 6czmB-3sggA:
undetectable
6czmC-3sggA:
undetectable		 6czmB-3sggA:
22.30
6czmC-3sggA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5q NUCLEOPROTEIN

(Mopeia Lassa
virus
reassortant 29) 		PF00843
(Arena_nucleocap) 		5 VAL A 199
VAL A 193
LEU A 202
LEU A 229
THR A 188
 None
 1.14A 6czmB-3t5qA:
undetectable
6czmC-3t5qA:
undetectable		 6czmB-3t5qA:
23.43
6czmC-3t5qA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v11 TRANSLATION
INITIATION FACTOR 2
SUBUNIT ALPHA

(Sulfolobus
solfataricus) 		PF00575
(S1)
PF07541
(EIF_2_alpha) 		5 VAL B  68
VAL B  29
GLY B  36
LEU B  37
GLN B  38
 None
 1.30A 6czmB-3v11B:
2.6
6czmC-3v11B:
undetectable		 6czmB-3v11B:
23.25
6czmC-3v11B:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		5 LEU A 653
GLY A 647
LEU A 336
GLN A 337
VAL A 638
 None
 1.26A 6czmB-3va6A:
undetectable
6czmC-3va6A:
undetectable		 6czmB-3va6A:
18.47
6czmC-3va6A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vre HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID

(Mammuthus
primigenius) 		PF00042
(Globin) 		5 VAL B 111
VAL B 137
LEU B 114
GLY B  72
LEU B  68
 None
 1.29A 6czmB-3vreB:
undetectable
6czmC-3vreB:
undetectable		 6czmB-3vreB:
18.18
6czmC-3vreB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wkm PUTATIVE ZINC
METALLOPROTEASE
AQ_1964

(Aquifex
aeolicus) 		PF00595
(PDZ)
PF13180
(PDZ_2) 		5 VAL A 234
VAL A 246
LEU A 259
GLY A 286
LEU A 287
 None
 1.27A 6czmB-3wkmA:
undetectable
6czmC-3wkmA:
undetectable		 6czmB-3wkmA:
23.40
6czmC-3wkmA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wry TM-1 PROTEIN

(Solanum
lycopersicum) 		PF06792
(UPF0261) 		5 VAL A 229
VAL A 300
LEU A 233
GLY A 264
VAL A 216
 None
 1.36A 6czmB-3wryA:
1.5
6czmC-3wryA:
undetectable		 6czmB-3wryA:
24.45
6czmC-3wryA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF00111
(Fer2)
PF14574
(DUF4445) 		6 VAL X  49
VAL X  58
LEU X  48
GLY X  62
LEU X  64
THR X  79
 None
 1.41A 6czmB-3zyyX:
undetectable
6czmC-3zyyX:
undetectable		 6czmB-3zyyX:
21.98
6czmC-3zyyX:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 VAL A 100
ASN A 163
LEU A  76
GLY A 167
LEU A 168
 EDO  A1514 (-3.8A)
None
EDO  A1514 (-4.2A)
None
None
 1.19A 6czmB-4akoA:
undetectable
6czmC-4akoA:
undetectable		 6czmB-4akoA:
19.43
6czmC-4akoA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fyu THIOREDOXIN

(Wuchereria
bancrofti) 		PF13905
(Thioredoxin_8) 		5 VAL A  66
VAL A  30
LEU A  99
GLY A 118
LEU A   4
 None
 1.24A 6czmB-4fyuA:
undetectable
6czmC-4fyuA:
undetectable		 6czmB-4fyuA:
17.63
6czmC-4fyuA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		5 LEU A 589
GLY A 635
LEU A 636
GLN A 633
THR A 628
 None
 1.31A 6czmB-4g3fA:
undetectable
6czmC-4g3fA:
undetectable		 6czmB-4g3fA:
24.53
6czmC-4g3fA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqn SPOROZOITE SURFACE
PROTEIN 2

(Plasmodium
vivax) 		PF00090
(TSP_1)
PF00092
(VWA) 		5 VAL A  49
VAL A 114
GLY A  70
LEU A  71
VAL A  64
 None
 1.20A 6czmB-4hqnA:
undetectable
6czmC-4hqnA:
undetectable		 6czmB-4hqnA:
20.56
6czmC-4hqnA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu2 PROBABLE CONSERVED
LIPOPROTEIN LPPS

(Mycobacterium
tuberculosis) 		no annotation 5 VAL A  79
GLY A 230
GLN A 117
THR A 145
VAL A  73
 None
 1.11A 6czmB-4hu2A:
undetectable
6czmC-4hu2A:
undetectable		 6czmB-4hu2A:
18.33
6czmC-4hu2A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igi COLLAGEN ALPHA3(VI)

(Mus musculus) 		PF00092
(VWA) 		5 VAL A1197
LEU A1136
GLY A1192
LEU A1191
VAL A1051
 None
 1.31A 6czmB-4igiA:
undetectable
6czmC-4igiA:
undetectable		 6czmB-4igiA:
21.17
6czmC-4igiA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k46 ADENYLATE KINASE

(Photobacterium
profundum) 		PF00406
(ADK)
PF05191
(ADK_lid) 		5 VAL A  52
LEU A  67
GLY A  46
LEU A  45
GLN A  48
 None
 1.23A 6czmB-4k46A:
undetectable
6czmC-4k46A:
undetectable		 6czmB-4k46A:
20.79
6czmC-4k46A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2j AMINOTRANSFERASE

(Streptomyces
lavendulae) 		PF00155
(Aminotran_1_2) 		5 VAL A 159
VAL A 138
LEU A 191
GLY A 176
LEU A 177
 None
 1.21A 6czmB-4m2jA:
undetectable
6czmC-4m2jA:
undetectable		 6czmB-4m2jA:
22.48
6czmC-4m2jA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgu STRUCTURAL PROTEIN
VP2

(Orthopteran
ambidensovirus
1) 		PF02336
(Denso_VP4) 		5 LEU A 253
GLY A 397
LEU A 329
THR A 400
VAL A 311
 None
 1.23A 6czmB-4mguA:
undetectable
6czmC-4mguA:
undetectable		 6czmB-4mguA:
21.21
6czmC-4mguA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mm0 P450-LIKE
MONOOXYGENASE

(Streptomyces
griseoviridis) 		PF00067
(p450) 		5 VAL A 394
VAL A 134
LEU A 370
LEU A 377
VAL A 246
 None
 1.19A 6czmB-4mm0A:
undetectable
6czmC-4mm0A:
undetectable		 6czmB-4mm0A:
25.74
6czmC-4mm0A:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 VAL A  65
VAL A  82
LEU A  68
GLY A 102
VAL A  79
 None
 1.22A 6czmB-4mrqA:
undetectable
6czmC-4mrqA:
undetectable		 6czmB-4mrqA:
22.10
6czmC-4mrqA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 VAL A 675
VAL A 465
GLY A 503
LEU A 502
VAL A 506
 None
 1.21A 6czmB-4oqjA:
undetectable
6czmC-4oqjA:
undetectable		 6czmB-4oqjA:
20.09
6czmC-4oqjA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1

(Bos taurus) 		PF13516
(LRR_6) 		5 VAL B  99
LEU B  85
GLY B  74
LEU B  75
VAL B  68
 None
 1.24A 6czmB-4peqB:
undetectable
6czmC-4peqB:
undetectable		 6czmB-4peqB:
24.35
6czmC-4peqB:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvv ADENOSINE KINASE

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		5 VAL A 241
LEU A 307
GLY A 280
LEU A 279
VAL A 244
 None
 1.13A 6czmB-4pvvA:
undetectable
6czmC-4pvvA:
undetectable		 6czmB-4pvvA:
23.56
6czmC-4pvvA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8l UNCHARACTERIZED
PROTEIN

(Cavia porcellus) 		PF00710
(Asparaginase) 		5 VAL A 264
ASN A 295
VAL A 304
GLY A 273
LEU A 312
 None
 1.32A 6czmB-4r8lA:
undetectable
6czmC-4r8lA:
undetectable		 6czmB-4r8lA:
23.98
6czmC-4r8lA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwr STAGE II SPORULATION
PROTEIN D

(Bacillus
anthracis) 		PF08486
(SpoIID) 		5 VAL A 264
VAL A 237
LEU A 268
GLN A 224
VAL A 286
 None
 1.36A 6czmB-4rwrA:
undetectable
6czmC-4rwrA:
undetectable		 6czmB-4rwrA:
20.69
6czmC-4rwrA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3p 4-ALPHA-GLUCANOTRANS
FERASE

(Escherichia
coli) 		PF02446
(Glyco_hydro_77) 		5 VAL A 148
LEU A 680
GLY A 634
LEU A 635
GLN A 636
 None
 1.22A 6czmB-4s3pA:
undetectable
6czmC-4s3pA:
undetectable		 6czmB-4s3pA:
19.00
6czmC-4s3pA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzo PROTEIN HTP-1
C. ELEGANS HIM-3
CLOSURE MOTIF

(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		PF02301
(HORMA)
no annotation 		5 ASN A 196
VAL A 111
LEU A  92
GLY B 280
VAL A 108
 None
 1.32A 6czmB-4tzoA:
undetectable
6czmC-4tzoA:
undetectable		 6czmB-4tzoA:
23.42
6czmC-4tzoA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ukd URIDYLMONOPHOSPHATE/
CYTIDYLMONOPHOSPHATE
KINASE

(Dictyostelium
discoideum) 		PF00406
(ADK) 		5 VAL A  71
VAL A  65
LEU A  74
GLY A  38
LEU A  40
 None
UDP  A 196 (-3.7A)
None
UDP  A 196 (-3.6A)
None
 1.13A 6czmB-4ukdA:
undetectable
6czmC-4ukdA:
undetectable		 6czmB-4ukdA:
20.44
6czmC-4ukdA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjw DUF3829 FAMILY
PROTEIN

(Bacteroides
vulgatus) 		no annotation 5 LEU A  54
GLY A 115
LEU A 117
THR A  92
VAL A  95
 None
 1.21A 6czmB-4yjwA:
undetectable
6czmC-4yjwA:
undetectable		 6czmB-4yjwA:
19.01
6czmC-4yjwA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2y CALO6

(Micromonospora
echinospora) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		5 VAL A 182
LEU A 247
GLN A 258
THR A 265
VAL A 266
 None
 1.31A 6czmB-4z2yA:
undetectable
6czmC-4z2yA:
undetectable		 6czmB-4z2yA:
22.78
6czmC-4z2yA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6h ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia
pseudotuberculosis) 		PF00156
(Pribosyltran) 		5 VAL A  65
GLY A 150
LEU A 149
GLN A 121
VAL A 153
 None
None
NA  A 503 ( 4.2A)
None
None
 1.31A 6czmB-5b6hA:
undetectable
6czmC-5b6hA:
undetectable		 6czmB-5b6hA:
19.72
6czmC-5b6hA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dne L-ASPARAGINASE

(Cavia porcellus) 		PF00710
(Asparaginase) 		5 VAL A 264
ASN A 295
VAL A 304
GLY A 273
LEU A 312
 None
 1.31A 6czmB-5dneA:
undetectable
6czmC-5dneA:
undetectable		 6czmB-5dneA:
21.90
6czmC-5dneA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8c UL34 PROTEIN

(Suid
alphaherpesvirus
1) 		PF04541
(Herpes_U34) 		5 VAL B 139
VAL B  40
LEU B  52
GLY B  84
VAL B  73
 None
 1.18A 6czmB-5e8cB:
undetectable
6czmC-5e8cB:
undetectable		 6czmB-5e8cB:
20.99
6czmC-5e8cB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eo9 CG32791, ISOFORM A

(Drosophila
melanogaster) 		PF07679
(I-set)
PF13927
(Ig_3) 		5 VAL B  45
ASN B 105
GLY B  69
LEU B  68
GLN B 104
 None
None
SO4  B 902 ( 4.7A)
None
SO4  B 903 (-4.2A)
 1.24A 6czmB-5eo9B:
undetectable
6czmC-5eo9B:
undetectable		 6czmB-5eo9B:
19.18
6czmC-5eo9B:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h46 DNA PROTECTION
DURING STARVATION
PROTEIN

(Mycolicibacterium
smegmatis) 		PF00210
(Ferritin) 		5 VAL A  68
LEU A  21
LEU A 127
GLN A 135
THR A 120
 None
None
None
FE2  A 203 ( 4.8A)
None
 1.26A 6czmB-5h46A:
undetectable
6czmC-5h46A:
undetectable		 6czmB-5h46A:
22.08
6czmC-5h46A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5l BACTERIOPHYTOCHROME
PROTEIN

(Agrobacterium
fabrum) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 VAL A 381
VAL A 415
LEU A 384
GLY A 418
LEU A 402
 None
 1.18A 6czmB-5i5lA:
undetectable
6czmC-5i5lA:
undetectable		 6czmB-5i5lA:
22.01
6czmC-5i5lA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw9 BASEPLATE WEDGE
PROTEIN GP25

(Escherichia
virus T4) 		PF04965
(GPW_gp25) 		5 VAL A 106
VAL A  81
LEU A 124
GLY A  38
LEU A  37
 None
 1.25A 6czmB-5iw9A:
undetectable
6czmC-5iw9A:
undetectable		 6czmB-5iw9A:
17.43
6czmC-5iw9A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpq ES7

(Chaetomium
thermophilum) 		PF01798
(Nop) 		5 VAL s  92
VAL s  45
LEU s  84
GLY s  20
LEU s  23
 None
 1.34A 6czmB-5jpqs:
undetectable
6czmC-5jpqs:
undetectable		 6czmB-5jpqs:
18.49
6czmC-5jpqs:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k69 L,D-TRANSPEPTIDASE 2

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		5 VAL A  79
GLY A 230
GLN A 117
THR A 145
VAL A  73
 None
 1.14A 6czmB-5k69A:
undetectable
6czmC-5k69A:
undetectable		 6czmB-5k69A:
21.78
6czmC-5k69A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum) 		PF12708
(Pectate_lyase_3) 		5 VAL A 615
LEU A 576
GLY A 534
LEU A 535
VAL A 623
 None
 0.94A 6czmB-5m60A:
undetectable
6czmC-5m60A:
undetectable		 6czmB-5m60A:
20.08
6czmC-5m60A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdn DNA POLYMERASE

(Pyrobaculum
calidifontis) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 VAL A 228
LEU A 293
GLY A 342
LEU A 343
VAL A 337
 None
 1.31A 6czmB-5mdnA:
undetectable
6czmC-5mdnA:
undetectable		 6czmB-5mdnA:
19.70
6czmC-5mdnA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uu1 SERINE/THREONINE-PRO
TEIN KINASE VRK2

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 172
GLY A 147
LEU A 146
GLN A 145
VAL A 153
 None
 1.30A 6czmB-5uu1A:
undetectable
6czmC-5uu1A:
undetectable		 6czmB-5uu1A:
25.94
6czmC-5uu1A:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v36 GLUTATHIONE
REDUCTASE

(Streptococcus
mutans) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 VAL A 215
VAL A 197
LEU A 214
GLY A 176
LEU A 203
 None
None
None
SO4  A 513 ( 3.9A)
None
 1.35A 6czmB-5v36A:
undetectable
6czmC-5v36A:
undetectable		 6czmB-5v36A:
22.22
6czmC-5v36A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Acinetobacter
baumannii) 		PF00464
(SHMT) 		5 VAL A 343
VAL A 388
LEU A  31
GLY A 383
LEU A 381
 None
 1.30A 6czmB-5vmbA:
undetectable
6czmC-5vmbA:
undetectable		 6czmB-5vmbA:
22.81
6czmC-5vmbA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxc CITRATE LYASE
SUBUNIT BETA-LIKE
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 5 VAL A 106
VAL A 128
LEU A  72
LEU A  99
VAL A  91
 None
 1.26A 6czmB-5vxcA:
undetectable
6czmC-5vxcA:
undetectable		 6czmB-5vxcA:
25.00
6czmC-5vxcA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4t CADHERIN 23

(Danio rerio) 		no annotation 5 VAL C  93
ASN C   8
LEU C  15
GLN C  31
VAL C  62
 None
None
None
MPD  C 408 ( 4.9A)
None
 1.22A 6czmB-5w4tC:
undetectable
6czmC-5w4tC:
undetectable		 6czmB-5w4tC:
undetectable
6czmC-5w4tC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czm -

(-) 		no annotation 5 GLY A 300
LEU A 301
GLN A 302
THR A 305
VAL A 325
 HIS  A 402 (-3.4A)
HIS  A 402 (-4.0A)
None
HIS  A 402 (-4.2A)
HIS  A 402 (-4.4A)
 0.58A 6czmB-6czmA:
37.0
6czmC-6czmA:
41.8		 6czmB-6czmA:
undetectable
6czmC-6czmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fiv RETROPEPSIN

(Feline
immunodeficiency
virus) 		PF00077
(RVP) 		5 VAL A  20
LEU A  73
GLY A 103
LEU A 102
VAL A  89
 None
 1.12A 6czmB-6fivA:
undetectable
6czmC-6fivA:
undetectable		 6czmB-6fivA:
14.49
6czmC-6fivA:
14.49