SIMILAR PATTERNS OF AMINO ACIDS FOR 6CZM_B_HISB402

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cfz HYDROGENASE 2
MATURATION PROTEASE

(Escherichia
coli) 		PF01750
(HycI) 		5 VAL A  23
VAL A 117
LEU A  26
LEU A 146
GLN A 144
 None
 1.31A 6czmA-1cfzA:
0.6
6czmB-1cfzA:
0.0		 6czmA-1cfzA:
23.01
6czmB-1cfzA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)

(Paracoccus
denitrificans) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 VAL A 301
LEU A 304
GLY A 292
LEU A 293
VAL A 254
 None
 1.12A 6czmA-1efpA:
0.0
6czmB-1efpA:
0.0		 6czmA-1efpA:
24.54
6czmB-1efpA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE F

(Bacillus
subtilis) 		PF00072
(Response_reg) 		5 VAL E1243
VAL E1278
LEU E1240
GLY E1262
VAL E1209
 None
 1.24A 6czmA-1f51E:
0.0
6czmB-1f51E:
1.5		 6czmA-1f51E:
16.43
6czmB-1f51E:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)

(Escherichia
coli) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 VAL A 384
VAL A 350
LEU A 385
GLY A 353
LEU A 354
 None
 1.33A 6czmA-1gsoA:
0.7
6czmB-1gsoA:
1.0		 6czmA-1gsoA:
21.13
6czmB-1gsoA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT

(Escherichia
coli) 		PF00701
(DHDPS) 		5 VAL A  31
VAL A  62
GLY A  49
LEU A  13
VAL A  44
 None
 1.22A 6czmA-1hl2A:
0.0
6czmB-1hl2A:
0.0		 6czmA-1hl2A:
23.37
6czmB-1hl2A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipi HOLLIDAY JUNCTION
RESOLVASE

(Pyrococcus
furiosus) 		PF01870
(Hjc) 		5 VAL A  77
VAL A 107
LEU A  43
GLY A 114
LEU A 113
 None
 1.31A 6czmA-1ipiA:
0.0
6czmB-1ipiA:
0.0		 6czmA-1ipiA:
16.29
6czmB-1ipiA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4j ACYL-HOMOSERINELACTO
NE SYNTHASE ESAI

(Pantoea
stewartii) 		PF00765
(Autoind_synth) 		5 LEU A 206
GLY A 187
LEU A 124
GLN A 120
THR A 194
 None
None
None
None
REO  A 405 ( 4.9A)
 1.14A 6czmA-1k4jA:
0.0
6czmB-1k4jA:
0.0		 6czmA-1k4jA:
20.06
6czmB-1k4jA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7f AMPA RECEPTOR
INTERACTING PROTEIN
GRIP

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 VAL A 673
LEU A 748
GLY A 683
LEU A 682
THR A 710
 None
 1.13A 6czmA-1n7fA:
undetectable
6czmB-1n7fA:
undetectable		 6czmA-1n7fA:
14.33
6czmB-1n7fA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ntg TYROSYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF01588
(tRNA_bind) 		5 VAL A  62
VAL A  20
GLY A  47
LEU A  48
VAL A  44
 None
 1.12A 6czmA-1ntgA:
undetectable
6czmB-1ntgA:
undetectable		 6czmA-1ntgA:
17.75
6czmB-1ntgA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC

(Klebsiella
pneumoniae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 VAL A  18
VAL A 172
LEU A  21
GLY A 106
LEU A 105
 None
 1.32A 6czmA-1ozhA:
undetectable
6czmB-1ozhA:
undetectable		 6czmA-1ozhA:
22.12
6czmB-1ozhA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tj7 ARGININOSUCCINATE
LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		5 VAL A  49
LEU A  50
GLY A 100
LEU A  99
GLN A  98
 None
 1.28A 6czmA-1tj7A:
undetectable
6czmB-1tj7A:
undetectable		 6czmA-1tj7A:
24.48
6czmB-1tj7A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ue0 ISOLEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1) 		5 VAL A 343
GLY A 356
LEU A 357
THR A 342
VAL A 351
 None
 1.13A 6czmA-1ue0A:
undetectable
6czmB-1ue0A:
undetectable		 6czmA-1ue0A:
21.51
6czmB-1ue0A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umf CHORISMATE SYNTHASE

(Helicobacter
pylori) 		PF01264
(Chorismate_synt) 		5 LEU A 343
GLY A 220
LEU A 221
GLN A 223
VAL A 279
 None
 1.19A 6czmA-1umfA:
undetectable
6czmB-1umfA:
2.0		 6czmA-1umfA:
24.51
6czmB-1umfA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		5 VAL A 175
LEU A 178
LEU A 191
GLN A 195
THR A 204
 None
 1.28A 6czmA-1vefA:
undetectable
6czmB-1vefA:
undetectable		 6czmA-1vefA:
22.71
6czmB-1vefA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsc HYPOTHETICAL PROTEIN
ST0229

(Sulfurisphaera
tokodaii) 		PF01871
(AMMECR1) 		5 VAL A 161
LEU A 173
GLY A 144
LEU A 145
VAL A 140
 None
 1.24A 6czmA-1wscA:
undetectable
6czmB-1wscA:
undetectable		 6czmA-1wscA:
23.27
6czmB-1wscA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxd SHIKIMATE
5-DEHYDROGENASE

(Thermus
thermophilus) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 VAL A 203
ASN A 177
GLY A 123
LEU A 122
VAL A 131
 None
 1.23A 6czmA-1wxdA:
undetectable
6czmB-1wxdA:
undetectable		 6czmA-1wxdA:
23.37
6czmB-1wxdA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp8 RECA PROTEIN

(Deinococcus
radiodurans) 		PF00154
(RecA) 		5 ASN A 262
VAL A 264
LEU A 235
GLY A  67
LEU A  63
 None
 1.34A 6czmA-1xp8A:
undetectable
6czmB-1xp8A:
undetectable		 6czmA-1xp8A:
24.30
6czmB-1xp8A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB

(Mycobacterium
tuberculosis) 		PF13350
(Y_phosphatase3) 		5 VAL A  15
LEU A  22
GLY A 179
LEU A 180
VAL A 174
 None
 1.23A 6czmA-1ywfA:
undetectable
6czmB-1ywfA:
undetectable		 6czmA-1ywfA:
23.20
6czmB-1ywfA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Lactococcus
lactis) 		PF13393
(tRNA-synt_His) 		5 LEU A 172
GLY A 210
LEU A 212
THR A 231
VAL A 228
 None
 1.34A 6czmA-1z7mA:
1.4
6czmB-1z7mA:
undetectable		 6czmA-1z7mA:
23.33
6czmB-1z7mA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bex RIBONUCLEASE
INHIBITOR

(Homo sapiens) 		PF13516
(LRR_6) 		5 VAL A 103
LEU A  89
GLY A  78
LEU A  79
VAL A  72
 None
 1.22A 6czmA-2bexA:
undetectable
6czmB-2bexA:
undetectable		 6czmA-2bexA:
23.44
6czmB-2bexA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0n A197

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 5 VAL A 113
LEU A 118
GLY A  87
THR A 162
VAL A  84
 None
 1.19A 6czmA-2c0nA:
undetectable
6czmB-2c0nA:
undetectable		 6czmA-2c0nA:
22.73
6czmB-2c0nA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3g ALPHA-AMYLASE G-6

(Bacillus
halodurans) 		PF16738
(CBM26) 		5 VAL A  31
LEU A  22
GLY A   6
THR A  27
VAL A  60
 None
 1.15A 6czmA-2c3gA:
undetectable
6czmB-2c3gA:
undetectable		 6czmA-2c3gA:
14.46
6czmB-2c3gA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cff 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)
METHYLIDENEAMINO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Thermotoga
maritima) 		PF00977
(His_biosynth) 		5 VAL A  36
VAL A  14
LEU A  39
GLY A 223
VAL A  49
 None
 1.11A 6czmA-2cffA:
undetectable
6czmB-2cffA:
undetectable		 6czmA-2cffA:
21.81
6czmB-2cffA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csw UBIQUITIN LIGASE
PROTEIN RNF8

(Homo sapiens) 		PF00498
(FHA) 		5 VAL A  46
LEU A 108
LEU A  50
GLN A  49
THR A  39
 None
 1.27A 6czmA-2cswA:
undetectable
6czmB-2cswA:
undetectable		 6czmA-2cswA:
16.48
6czmB-2cswA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4v ISOCITRATE
DEHYDROGENASE

(Acidithiobacillus
thiooxidans) 		PF00180
(Iso_dh) 		5 VAL A 322
VAL A 293
LEU A 326
GLN A 301
VAL A 312
 None
 0.89A 6czmA-2d4vA:
undetectable
6czmB-2d4vA:
undetectable		 6czmA-2d4vA:
24.26
6czmB-2d4vA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5x BUGD

(Bordetella
pertussis) 		PF03401
(TctC) 		5 LEU A  26
GLY A  94
LEU A 247
GLN A 248
VAL A  97
 None
 1.28A 6czmA-2f5xA:
6.0
6czmB-2f5xA:
3.6		 6czmA-2f5xA:
23.22
6czmB-2f5xA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  37
VAL A  82
LEU A  29
LEU A 100
THR A 164
 J60  A1305 (-4.8A)
J60  A1305 ( 4.7A)
J60  A1305 (-3.9A)
J60  A1305 (-4.4A)
J60  A1305 ( 4.4A)
 1.28A 6czmA-2jamA:
undetectable
6czmB-2jamA:
undetectable		 6czmA-2jamA:
22.05
6czmB-2jamA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mii PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOB

(Escherichia
coli) 		PF13036
(LpoB) 		5 VAL A  89
LEU A 109
GLY A 190
GLN A 177
VAL A  72
 None
 1.22A 6czmA-2miiA:
undetectable
6czmB-2miiA:
undetectable		 6czmA-2miiA:
20.73
6czmB-2miiA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vea PHYTOCHROME-LIKE
PROTEIN CPH1

(Synechocystis
sp. PCC 6803) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 VAL A 388
VAL A 422
LEU A 391
GLY A 425
LEU A 409
 None
 1.25A 6czmA-2veaA:
undetectable
6czmB-2veaA:
undetectable		 6czmA-2veaA:
22.68
6czmB-2veaA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2s MATRIX PROTEIN

(Lagos bat
lyssavirus) 		PF04785
(Rhabdo_M2) 		5 VAL A 157
LEU A 120
GLY A  98
LEU A  99
VAL A  92
 None
 1.21A 6czmA-2w2sA:
undetectable
6czmB-2w2sA:
undetectable		 6czmA-2w2sA:
21.57
6czmB-2w2sA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we8 XANTHINE
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF02625
(XdhC_CoxI)
PF13478
(XdhC_C) 		5 VAL A  43
LEU A 114
GLY A  10
LEU A   9
VAL A  15
 None
 1.02A 6czmA-2we8A:
undetectable
6czmB-2we8A:
undetectable		 6czmA-2we8A:
24.07
6czmB-2we8A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we8 XANTHINE
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF02625
(XdhC_CoxI)
PF13478
(XdhC_C) 		5 VAL A 196
VAL A 147
LEU A 181
GLY A 171
LEU A 172
 None
 0.83A 6czmA-2we8A:
undetectable
6czmB-2we8A:
undetectable		 6czmA-2we8A:
24.07
6czmB-2we8A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00344
(SecY)
PF10559
(Plug_translocon) 		5 VAL A 296
LEU A 263
GLY A 459
LEU A 289
VAL A 454
 None
 1.26A 6czmA-2ww9A:
undetectable
6czmB-2ww9A:
undetectable		 6czmA-2ww9A:
20.80
6czmB-2ww9A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxz THIAMIN-MONOPHOSPHAT
E KINASE

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 VAL A 264
LEU A 154
LEU A 217
GLN A 219
VAL A 225
 None
 1.03A 6czmA-2yxzA:
2.7
6czmB-2yxzA:
2.4		 6czmA-2yxzA:
24.43
6czmB-2yxzA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0s PROBABLE EXOSOME
COMPLEX RNA-BINDING
PROTEIN 1

(Aeropyrum
pernix) 		PF15985
(KH_6) 		5 LEU A 114
GLY A 101
LEU A 100
GLN A  97
VAL A 138
 None
 1.00A 6czmA-2z0sA:
undetectable
6czmB-2z0sA:
undetectable		 6czmA-2z0sA:
24.77
6czmB-2z0sA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zie PUTATIVE
MODIFICATION
METHYLASE

(Thermus
thermophilus) 		PF01555
(N6_N4_Mtase) 		5 VAL A  79
LEU A  33
GLY A 262
THR A  46
VAL A  44
 None
 1.34A 6czmA-2zieA:
undetectable
6czmB-2zieA:
undetectable		 6czmA-2zieA:
23.06
6czmB-2zieA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3awd PUTATIVE POLYOL
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF13561
(adh_short_C2) 		5 VAL A  51
LEU A  54
GLY A  23
LEU A  24
GLN A  20
 None
 1.13A 6czmA-3awdA:
undetectable
6czmB-3awdA:
undetectable		 6czmA-3awdA:
23.70
6czmB-3awdA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc8 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Mus musculus) 		PF05889
(SepSecS) 		5 LEU A 454
GLY A 392
LEU A 391
GLN A 390
VAL A 400
 None
 1.32A 6czmA-3bc8A:
0.9
6czmB-3bc8A:
0.9		 6czmA-3bc8A:
20.80
6czmB-3bc8A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj1 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 2

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		5 VAL A 143
VAL A  77
LEU A 147
LEU A 100
THR A  51
 None
 1.08A 6czmA-3cj1A:
undetectable
6czmB-3cj1A:
undetectable		 6czmA-3cj1A:
24.63
6czmB-3cj1A:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eiq PROGRAMMED CELL
DEATH PROTEIN 4

(Mus musculus) 		PF02847
(MA3) 		5 VAL C 200
VAL C 230
LEU C 168
LEU C 191
VAL C 184
 None
 1.32A 6czmA-3eiqC:
undetectable
6czmB-3eiqC:
undetectable		 6czmA-3eiqC:
23.19
6czmB-3eiqC:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3exs RMPD
(HEXULOSE-6-PHOSPHAT
E SYNTHASE)

(Streptococcus
mutans) 		PF00215
(OMPdecase) 		5 VAL A  51
VAL A  44
LEU A  52
GLY A  37
LEU A  12
 None
 1.22A 6czmA-3exsA:
undetectable
6czmB-3exsA:
undetectable		 6czmA-3exsA:
24.25
6czmB-3exsA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF00464
(SHMT) 		5 VAL A 344
VAL A 389
LEU A  32
GLY A 384
LEU A 382
 None
 1.29A 6czmA-3g8mA:
0.7
6czmB-3g8mA:
undetectable		 6czmA-3g8mA:
23.71
6czmB-3g8mA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3id1 REGULATOR OF SIGMA E
PROTEASE

(Escherichia
coli) 		no annotation 5 VAL A 165
VAL A 131
LEU A 169
GLY A 214
LEU A 213
 None
 1.35A 6czmA-3id1A:
undetectable
6czmB-3id1A:
undetectable		 6czmA-3id1A:
15.69
6czmB-3id1A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3keh GLUCOCEREBROSIDASE

(Homo sapiens) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		5 VAL A 460
LEU A 444
GLY A  64
LEU A  65
THR A 482
 None
 1.12A 6czmA-3kehA:
undetectable
6czmB-3kehA:
undetectable		 6czmA-3kehA:
22.51
6czmB-3kehA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvu ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Ruegeria
pomeroyi) 		PF00496
(SBP_bac_5) 		5 VAL A 319
ASN A 321
LEU A 522
GLY A 515
LEU A 486
 None
 1.34A 6czmA-3lvuA:
undetectable
6czmB-3lvuA:
undetectable		 6czmA-3lvuA:
22.03
6czmB-3lvuA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Novosphingobium
aromaticivorans) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		5 VAL A 187
LEU A 340
GLY A 193
LEU A 196
VAL A 191
 None
 1.24A 6czmA-3lxdA:
undetectable
6czmB-3lxdA:
undetectable		 6czmA-3lxdA:
21.76
6czmB-3lxdA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Yersinia pestis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 VAL A 384
VAL A 350
LEU A 385
GLY A 353
LEU A 354
 None
 1.36A 6czmA-3mjfA:
undetectable
6czmB-3mjfA:
undetectable		 6czmA-3mjfA:
24.29
6czmB-3mjfA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwt NUCLEOPROTEIN

(Lassa
mammarenavirus) 		PF00843
(Arena_nucleocap)
PF17290
(Arena_ncap_C) 		5 VAL A 199
VAL A 193
LEU A 202
LEU A 229
THR A 188
 None
 1.20A 6czmA-3mwtA:
undetectable
6czmB-3mwtA:
undetectable		 6czmA-3mwtA:
20.70
6czmB-3mwtA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvn PLEXIN-C1

(Homo sapiens) 		PF01437
(PSI) 		5 VAL B 166
LEU B 177
GLY B 126
LEU B 108
VAL B 136
 None
 1.14A 6czmA-3nvnB:
undetectable
6czmB-3nvnB:
undetectable		 6czmA-3nvnB:
23.32
6czmB-3nvnB:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orj SUGAR-BINDING
PROTEIN

(Bacteroides
ovatus) 		no annotation 5 VAL A 279
LEU A 332
LEU A 271
GLN A 276
VAL A 439
 None
 1.30A 6czmA-3orjA:
undetectable
6czmB-3orjA:
undetectable		 6czmA-3orjA:
21.33
6czmB-3orjA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 VAL B 557
VAL B 665
GLY B 594
LEU B 552
THR B 679
 None
 1.35A 6czmA-3pcoB:
undetectable
6czmB-3pcoB:
2.6		 6czmA-3pcoB:
17.63
6czmB-3pcoB:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pow CALRETICULIN

(Homo sapiens) 		PF00262
(Calreticulin) 		5 LEU A 316
GLY A  65
LEU A  66
THR A 325
VAL A  97
 None
CA  A 900 ( 4.9A)
None
None
None
 1.06A 6czmA-3powA:
undetectable
6czmB-3powA:
undetectable		 6czmA-3powA:
21.66
6czmB-3powA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r27 HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN L

(Homo sapiens) 		PF00076
(RRM_1) 		5 VAL A 142
LEU A 118
GLY A 108
LEU A 109
VAL A 171
 None
 1.34A 6czmA-3r27A:
3.3
6czmB-3r27A:
3.2		 6czmA-3r27A:
11.21
6czmB-3r27A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg0 CALRETICULIN

(Mus musculus) 		PF00262
(Calreticulin) 		5 LEU A 316
GLY A  65
LEU A  66
THR A 325
VAL A  97
 None
CA  A   1 ( 4.9A)
None
None
None
 1.09A 6czmA-3rg0A:
undetectable
6czmB-3rg0A:
undetectable		 6czmA-3rg0A:
22.48
6czmB-3rg0A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgg HYPOTHETICAL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF14323
(GxGYxYP_C)
PF16216
(GxGYxYP_N) 		5 VAL A 530
VAL A 540
GLY A 357
LEU A 356
VAL A 515
 None
 1.29A 6czmA-3sggA:
undetectable
6czmB-3sggA:
undetectable		 6czmA-3sggA:
22.30
6czmB-3sggA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5q NUCLEOPROTEIN

(Mopeia Lassa
virus
reassortant 29) 		PF00843
(Arena_nucleocap) 		5 VAL A 199
VAL A 193
LEU A 202
LEU A 229
THR A 188
 None
 1.16A 6czmA-3t5qA:
undetectable
6czmB-3t5qA:
undetectable		 6czmA-3t5qA:
23.43
6czmB-3t5qA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v11 TRANSLATION
INITIATION FACTOR 2
SUBUNIT ALPHA

(Sulfolobus
solfataricus) 		PF00575
(S1)
PF07541
(EIF_2_alpha) 		5 VAL B  68
VAL B  29
GLY B  36
LEU B  37
GLN B  38
 None
 1.28A 6czmA-3v11B:
2.1
6czmB-3v11B:
3.1		 6czmA-3v11B:
23.25
6czmB-3v11B:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		5 LEU A 653
GLY A 647
LEU A 336
GLN A 337
VAL A 638
 None
 1.28A 6czmA-3va6A:
undetectable
6czmB-3va6A:
undetectable		 6czmA-3va6A:
18.47
6czmB-3va6A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wkm PUTATIVE ZINC
METALLOPROTEASE
AQ_1964

(Aquifex
aeolicus) 		PF00595
(PDZ)
PF13180
(PDZ_2) 		5 VAL A 234
VAL A 246
LEU A 259
GLY A 286
LEU A 287
 None
 1.26A 6czmA-3wkmA:
undetectable
6czmB-3wkmA:
undetectable		 6czmA-3wkmA:
23.40
6czmB-3wkmA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF00111
(Fer2)
PF14574
(DUF4445) 		6 VAL X  49
VAL X  58
LEU X  48
GLY X  62
LEU X  64
THR X  79
 None
 1.39A 6czmA-3zyyX:
undetectable
6czmB-3zyyX:
undetectable		 6czmA-3zyyX:
21.98
6czmB-3zyyX:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE

(Anaerococcus
prevotii) 		PF01071
(GARS_A) 		5 VAL A 259
VAL A 204
LEU A 273
GLY A 251
LEU A 252
 None
 1.33A 6czmA-4dimA:
undetectable
6czmB-4dimA:
undetectable		 6czmA-4dimA:
22.57
6czmB-4dimA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9u CG32412

(Drosophila
melanogaster) 		PF04389
(Peptidase_M28) 		5 VAL A 127
VAL A 295
LEU A  49
GLY A 221
LEU A 306
 None
 1.34A 6czmA-4f9uA:
undetectable
6czmB-4f9uA:
undetectable		 6czmA-4f9uA:
23.58
6czmB-4f9uA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		5 LEU A 589
GLY A 635
LEU A 636
GLN A 633
THR A 628
 None
 1.30A 6czmA-4g3fA:
undetectable
6czmB-4g3fA:
undetectable		 6czmA-4g3fA:
24.53
6czmB-4g3fA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqf THROMBOSPONDIN-RELAT
ED ANONYMOUS
PROTEIN, TRAP

(Plasmodium
falciparum) 		PF00092
(VWA) 		5 LEU A 160
GLY A 228
LEU A  75
GLN A  77
VAL A 223
 None
 1.26A 6czmA-4hqfA:
undetectable
6czmB-4hqfA:
undetectable		 6czmA-4hqfA:
23.27
6czmB-4hqfA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqn SPOROZOITE SURFACE
PROTEIN 2

(Plasmodium
vivax) 		PF00090
(TSP_1)
PF00092
(VWA) 		5 VAL A  49
VAL A 114
GLY A  70
LEU A  71
VAL A  64
 None
 1.25A 6czmA-4hqnA:
undetectable
6czmB-4hqnA:
undetectable		 6czmA-4hqnA:
20.56
6czmB-4hqnA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu2 PROBABLE CONSERVED
LIPOPROTEIN LPPS

(Mycobacterium
tuberculosis) 		no annotation 5 VAL A  79
GLY A 230
GLN A 117
THR A 145
VAL A  73
 None
 1.14A 6czmA-4hu2A:
undetectable
6czmB-4hu2A:
undetectable		 6czmA-4hu2A:
18.33
6czmB-4hu2A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igi COLLAGEN ALPHA3(VI)

(Mus musculus) 		PF00092
(VWA) 		5 VAL A1197
LEU A1136
GLY A1192
LEU A1191
VAL A1051
 None
 1.27A 6czmA-4igiA:
undetectable
6czmB-4igiA:
undetectable		 6czmA-4igiA:
21.17
6czmB-4igiA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k46 ADENYLATE KINASE

(Photobacterium
profundum) 		PF00406
(ADK)
PF05191
(ADK_lid) 		5 VAL A  52
LEU A  67
GLY A  46
LEU A  45
GLN A  48
 None
 1.25A 6czmA-4k46A:
undetectable
6czmB-4k46A:
undetectable		 6czmA-4k46A:
20.79
6czmB-4k46A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ln1 L-LACTATE
DEHYDROGENASE 1

(Bacillus cereus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A  77
GLY A 137
LEU A 138
THR A 132
VAL A 106
 None
 1.20A 6czmA-4ln1A:
undetectable
6czmB-4ln1A:
undetectable		 6czmA-4ln1A:
23.10
6czmB-4ln1A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgu STRUCTURAL PROTEIN
VP2

(Orthopteran
ambidensovirus
1) 		PF02336
(Denso_VP4) 		5 LEU A 253
GLY A 397
LEU A 329
THR A 400
VAL A 311
 None
 1.22A 6czmA-4mguA:
undetectable
6czmB-4mguA:
undetectable		 6czmA-4mguA:
21.21
6czmB-4mguA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mm0 P450-LIKE
MONOOXYGENASE

(Streptomyces
griseoviridis) 		PF00067
(p450) 		5 VAL A 394
VAL A 134
LEU A 370
LEU A 377
VAL A 246
 None
 1.19A 6czmA-4mm0A:
undetectable
6czmB-4mm0A:
undetectable		 6czmA-4mm0A:
25.74
6czmB-4mm0A:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn6 SENSOR PROTEIN
KINASE WALK

(Staphylococcus
aureus) 		PF13426
(PAS_9) 		5 VAL A 311
LEU A 312
GLY A 275
LEU A 363
VAL A 288
 None
 1.30A 6czmA-4mn6A:
undetectable
6czmB-4mn6A:
undetectable		 6czmA-4mn6A:
16.67
6czmB-4mn6A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1

(Bos taurus) 		PF13516
(LRR_6) 		6 VAL B  99
LEU B  85
GLY B  74
LEU B  75
GLN B  76
VAL B  68
 None
 1.47A 6czmA-4peqB:
undetectable
6czmB-4peqB:
undetectable		 6czmA-4peqB:
24.35
6czmB-4peqB:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8l UNCHARACTERIZED
PROTEIN

(Cavia porcellus) 		PF00710
(Asparaginase) 		5 VAL A 264
ASN A 295
VAL A 304
GLY A 273
LEU A 312
 None
 1.30A 6czmA-4r8lA:
undetectable
6czmB-4r8lA:
undetectable		 6czmA-4r8lA:
23.98
6czmB-4r8lA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ukd URIDYLMONOPHOSPHATE/
CYTIDYLMONOPHOSPHATE
KINASE

(Dictyostelium
discoideum) 		PF00406
(ADK) 		5 VAL A  71
VAL A  65
LEU A  74
GLY A  38
LEU A  40
 None
UDP  A 196 (-3.7A)
None
UDP  A 196 (-3.6A)
None
 1.14A 6czmA-4ukdA:
undetectable
6czmB-4ukdA:
undetectable		 6czmA-4ukdA:
20.44
6czmB-4ukdA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ut7 BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE2
A11

(Homo sapiens) 		PF07686
(V-set) 		5 VAL L  11
LEU L 104
GLY L  77
LEU L  78
GLN L  17
 None
 1.25A 6czmA-4ut7L:
undetectable
6czmB-4ut7L:
undetectable		 6czmA-4ut7L:
17.99
6czmB-4ut7L:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu9 BETA-N-ACETYLHEXOSAM
INIDASE

(Beutenbergia
cavernae) 		PF00933
(Glyco_hydro_3) 		5 ASN A 214
VAL A 205
GLY A 256
LEU A 257
VAL A 201
 None
 1.33A 6czmA-5bu9A:
undetectable
6czmB-5bu9A:
undetectable		 6czmA-5bu9A:
24.63
6czmB-5bu9A:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dne L-ASPARAGINASE

(Cavia porcellus) 		PF00710
(Asparaginase) 		5 VAL A 264
ASN A 295
VAL A 304
GLY A 273
LEU A 312
 None
 1.28A 6czmA-5dneA:
undetectable
6czmB-5dneA:
undetectable		 6czmA-5dneA:
21.90
6czmB-5dneA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8c UL34 PROTEIN

(Suid
alphaherpesvirus
1) 		PF04541
(Herpes_U34) 		5 VAL B 139
VAL B  40
LEU B  52
GLY B  84
VAL B  73
 None
 1.19A 6czmA-5e8cB:
undetectable
6czmB-5e8cB:
undetectable		 6czmA-5e8cB:
20.99
6czmB-5e8cB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkx UNCHARACTERIZED
PROTEIN

(Thermococcus
onnurineus) 		PF14336
(DUF4392) 		5 VAL A 204
VAL A  44
LEU A 215
GLY A  77
LEU A  76
 None
 1.19A 6czmA-5gkxA:
undetectable
6czmB-5gkxA:
undetectable		 6czmA-5gkxA:
23.94
6czmB-5gkxA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvq SPLICING FACTOR 3B
SUBUNIT 4

(Homo sapiens) 		PF00076
(RRM_1) 		5 VAL A  62
LEU A  32
GLY A  22
LEU A  23
VAL A  89
 None
 1.31A 6czmA-5gvqA:
2.9
6czmB-5gvqA:
3.0		 6czmA-5gvqA:
18.30
6czmB-5gvqA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h46 DNA PROTECTION
DURING STARVATION
PROTEIN

(Mycolicibacterium
smegmatis) 		PF00210
(Ferritin) 		5 VAL A  68
LEU A  21
LEU A 127
GLN A 135
THR A 120
 None
None
None
FE2  A 203 ( 4.8A)
None
 1.25A 6czmA-5h46A:
undetectable
6czmB-5h46A:
undetectable		 6czmA-5h46A:
22.08
6czmB-5h46A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5l BACTERIOPHYTOCHROME
PROTEIN

(Agrobacterium
fabrum) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 VAL A 381
VAL A 415
LEU A 384
GLY A 418
LEU A 402
 None
 1.19A 6czmA-5i5lA:
undetectable
6czmB-5i5lA:
undetectable		 6czmA-5i5lA:
22.01
6czmB-5i5lA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipf HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE (HGPRT)

(Schistosoma
mansoni) 		PF00156
(Pribosyltran) 		5 VAL A 189
VAL A 213
LEU A 170
GLY A 196
LEU A 199
 None
None
None
None
IMP  A1300 ( 4.4A)
 1.29A 6czmA-5ipfA:
undetectable
6czmB-5ipfA:
undetectable		 6czmA-5ipfA:
22.38
6czmB-5ipfA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw9 BASEPLATE WEDGE
PROTEIN GP25

(Escherichia
virus T4) 		PF04965
(GPW_gp25) 		5 VAL A 106
VAL A  81
LEU A 124
GLY A  38
LEU A  37
 None
 1.27A 6czmA-5iw9A:
undetectable
6czmB-5iw9A:
undetectable		 6czmA-5iw9A:
17.43
6czmB-5iw9A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum) 		PF12708
(Pectate_lyase_3) 		5 VAL A 615
LEU A 576
GLY A 534
LEU A 535
VAL A 623
 None
 0.96A 6czmA-5m60A:
undetectable
6czmB-5m60A:
undetectable		 6czmA-5m60A:
20.08
6czmB-5m60A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN

(Homo sapiens) 		no annotation 5 VAL L  10
LEU L 107
GLY L  78
LEU L  79
GLN L  16
 None
 1.35A 6czmA-5ocyL:
undetectable
6czmB-5ocyL:
undetectable		 6czmA-5ocyL:
undetectable
6czmB-5ocyL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tbx COLD-INDUCIBLE
RNA-BINDING PROTEIN

(Homo sapiens) 		PF00076
(RRM_1) 		5 VAL A  53
LEU A  23
GLY A  13
LEU A  14
VAL A  80
 None
 1.29A 6czmA-5tbxA:
4.0
6czmB-5tbxA:
4.0		 6czmA-5tbxA:
14.53
6czmB-5tbxA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tmh POLYPROTEIN

(Zika virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 VAL A 618
VAL A 662
LEU A 382
GLY A 505
LEU A 657
 None
 1.34A 6czmA-5tmhA:
undetectable
6czmB-5tmhA:
undetectable		 6czmA-5tmhA:
17.39
6czmB-5tmhA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uu1 SERINE/THREONINE-PRO
TEIN KINASE VRK2

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 172
GLY A 147
LEU A 146
GLN A 145
VAL A 153
 None
 1.27A 6czmA-5uu1A:
undetectable
6czmB-5uu1A:
undetectable		 6czmA-5uu1A:
25.94
6czmB-5uu1A:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v36 GLUTATHIONE
REDUCTASE

(Streptococcus
mutans) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 VAL A 215
VAL A 197
LEU A 214
GLY A 176
LEU A 203
 None
None
None
SO4  A 513 ( 3.9A)
None
 1.33A 6czmA-5v36A:
undetectable
6czmB-5v36A:
undetectable		 6czmA-5v36A:
22.22
6czmB-5v36A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Acinetobacter
baumannii) 		PF00464
(SHMT) 		5 VAL A 343
VAL A 388
LEU A  31
GLY A 383
LEU A 381
 None
 1.31A 6czmA-5vmbA:
undetectable
6czmB-5vmbA:
undetectable		 6czmA-5vmbA:
22.81
6czmB-5vmbA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4t CADHERIN 23

(Danio rerio) 		no annotation 5 VAL C  93
ASN C   8
LEU C  15
GLN C  31
VAL C  62
 None
None
None
MPD  C 408 ( 4.9A)
None
 1.13A 6czmA-5w4tC:
undetectable
6czmB-5w4tC:
undetectable		 6czmA-5w4tC:
undetectable
6czmB-5w4tC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpq UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV0081

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A  29
GLY A  56
LEU A  55
GLN A  54
VAL A  63
 None
 1.34A 6czmA-5xpqA:
undetectable
6czmB-5xpqA:
undetectable		 6czmA-5xpqA:
undetectable
6czmB-5xpqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0u NEOPULLULANASE 1

(Thermoactinomyces
vulgaris) 		no annotation 5 VAL A 623
GLY A 571
LEU A 599
GLN A 598
VAL A 582
 None
 1.33A 6czmA-5z0uA:
undetectable
6czmB-5z0uA:
undetectable		 6czmA-5z0uA:
undetectable
6czmB-5z0uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apq ANTI-MARBURGVIRUS
NUCLEOPROTEIN SINGLE
DOMAIN ANTIBODY B

(Lama glama) 		no annotation 5 VAL A  78
LEU A  34
GLY A 109
LEU A   4
GLN A   5
 None
 1.33A 6czmA-6apqA:
undetectable
6czmB-6apqA:
undetectable		 6czmA-6apqA:
14.77
6czmB-6apqA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czm -

(-) 		no annotation 5 GLY A 300
LEU A 301
GLN A 302
THR A 305
VAL A 325
 HIS  A 402 (-3.4A)
HIS  A 402 (-4.0A)
None
HIS  A 402 (-4.2A)
HIS  A 402 (-4.4A)
 0.52A 6czmA-6czmA:
46.0
6czmB-6czmA:
37.0		 6czmA-6czmA:
undetectable
6czmB-6czmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dxp -

(-) 		no annotation 5 LEU A  89
GLY A 161
LEU A 160
THR A 117
VAL A 129
 None
 1.21A 6czmA-6dxpA:
undetectable
6czmB-6dxpA:
undetectable		 6czmA-6dxpA:
undetectable
6czmB-6dxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fiv RETROPEPSIN

(Feline
immunodeficiency
virus) 		PF00077
(RVP) 		5 VAL A  20
LEU A  73
GLY A 103
LEU A 102
VAL A  89
 None
 1.07A 6czmA-6fivA:
undetectable
6czmB-6fivA:
undetectable		 6czmA-6fivA:
14.49
6czmB-6fivA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkq NETRIN-1

(Homo sapiens) 		no annotation 5 VAL A 147
VAL A 276
GLY A 216
LEU A 217
GLN A 150
 None
 1.32A 6czmA-6fkqA:
undetectable
6czmB-6fkqA:
undetectable		 6czmA-6fkqA:
undetectable
6czmB-6fkqA:
undetectable