SIMILAR PATTERNS OF AMINO ACIDS FOR 6CZM_A_HISA402

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cs1 PROTEIN
(CYSTATHIONINE
GAMMA-SYNTHASE)

(Escherichia
coli) 		PF01053
(Cys_Met_Meta_PP) 		5 GLY A 244
VAL A 210
VAL A 206
ALA A 208
LEU A  61
 None
 1.08A 6czmA-1cs1A:
0.3
6czmC-1cs1A:
undetectable		 6czmA-1cs1A:
23.23
6czmC-1cs1A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddz CARBONIC ANHYDRASE

(Porphyridium
purpureum) 		PF00484
(Pro_CA) 		5 GLY A 402
VAL A 455
CYH A 457
VAL A 421
LEU A 550
 None
 0.83A 6czmA-1ddzA:
0.3
6czmC-1ddzA:
undetectable		 6czmA-1ddzA:
20.94
6czmC-1ddzA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsw L-ASPARTATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 LEU A 163
VAL A 156
VAL A 280
ALA A 222
LEU A 284
 None
 1.07A 6czmA-1jswA:
undetectable
6czmC-1jswA:
undetectable		 6czmA-1jswA:
22.41
6czmC-1jswA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ko0 DIAMINOPIMELATE
DECARBOXYLASE

(Escherichia
coli) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 GLY A 226
LEU A 228
VAL A 274
ALA A 377
LEU A 273
 PLP  A 540 (-3.6A)
None
None
None
None
 1.12A 6czmA-1ko0A:
undetectable
6czmC-1ko0A:
undetectable		 6czmA-1ko0A:
24.27
6czmC-1ko0A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE

(Homo sapiens) 		PF01467
(CTP_transf_like) 		5 LEU A 159
THR A 187
CYH A 155
ALA A 193
LEU A 183
 DND  A 301 (-4.1A)
None
DND  A 301 (-4.7A)
None
None
 0.98A 6czmA-1kqoA:
0.2
6czmC-1kqoA:
undetectable		 6czmA-1kqoA:
22.37
6czmC-1kqoA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfp HYPOTHETICAL PROTEIN
AQ_1575

(Aquifex
aeolicus) 		PF01709
(Transcrip_reg) 		5 GLY A 122
VAL A 234
VAL A  95
ALA A 236
LEU A 225
 None
 1.15A 6czmA-1lfpA:
5.0
6czmC-1lfpA:
undetectable		 6czmA-1lfpA:
22.07
6czmC-1lfpA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		5 GLY A 595
LEU A 596
VAL A 607
ALA A 591
LEU A 653
 None
 1.16A 6czmA-1lufA:
undetectable
6czmC-1lufA:
undetectable		 6czmA-1lufA:
21.43
6czmC-1lufA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhs PLASMA MEMBRANE
ATPASE

(Neurospora
crassa) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		5 GLY A 349
THR A 343
VAL A 169
ALA A 165
LEU A 172
 None
 0.97A 6czmA-1mhsA:
undetectable
6czmC-1mhsA:
undetectable		 6czmA-1mhsA:
20.90
6czmC-1mhsA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC

(Klebsiella
pneumoniae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		6 GLY A 106
LEU A 105
VAL A  18
VAL A 172
ALA A  14
LEU A  21
 None
 1.35A 6czmA-1ozhA:
0.2
6czmC-1ozhA:
2.4		 6czmA-1ozhA:
22.12
6czmC-1ozhA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pn4 PEROXISOMAL
HYDRATASE-DEHYDROGEN
ASE-EPIMERASE

(Candida
tropicalis) 		PF01575
(MaoC_dehydratas) 		5 GLY A 210
LEU A 211
CYH A 207
ALA A 265
LEU A 203
 None
 0.89A 6czmA-1pn4A:
undetectable
6czmC-1pn4A:
undetectable		 6czmA-1pn4A:
20.50
6czmC-1pn4A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ue0 ISOLEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1) 		5 GLY A 356
LEU A 357
THR A 342
VAL A 351
VAL A 343
 None
 1.12A 6czmA-1ue0A:
undetectable
6czmC-1ue0A:
undetectable		 6czmA-1ue0A:
21.51
6czmC-1ue0A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa0 PUTATIVE NADPH
DEPENDENT
OXIDOREDUCTASES

(Geobacillus
stearothermophilus) 		PF00107
(ADH_zinc_N) 		5 GLY A 269
LEU A 267
VAL A 232
ALA A 220
LEU A 229
 None
 1.09A 6czmA-1xa0A:
undetectable
6czmC-1xa0A:
undetectable		 6czmA-1xa0A:
25.00
6czmC-1xa0A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvx YFUA

(Yersinia
enterocolitica) 		PF13343
(SBP_bac_6) 		5 GLY A  38
THR A  61
VAL A  70
ALA A  66
LEU A  47
 ZN  A 314 ( 4.3A)
None
None
None
None
 1.09A 6czmA-1xvxA:
5.5
6czmC-1xvxA:
4.3		 6czmA-1xvxA:
21.08
6czmC-1xvxA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvy SFUA

(Yersinia
enterocolitica) 		PF13343
(SBP_bac_6) 		5 GLY A  35
THR A  58
VAL A  67
ALA A  63
LEU A  44
 None
 1.09A 6czmA-1xvyA:
6.7
6czmC-1xvyA:
5.4		 6czmA-1xvyA:
22.70
6czmC-1xvyA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE

(Chromobacterium
violaceum) 		PF01869
(BcrAD_BadFG) 		5 GLY A 236
LEU A 264
VAL A 218
ALA A 222
LEU A 163
 None
 1.15A 6czmA-1zc6A:
undetectable
6czmC-1zc6A:
undetectable		 6czmA-1zc6A:
24.00
6czmC-1zc6A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D

(Pyrococcus
abyssi) 		PF00710
(Asparaginase) 		5 GLY A  98
LEU A 141
THR A  95
VAL A 172
ALA A 164
 None
 0.97A 6czmA-1zq1A:
undetectable
6czmC-1zq1A:
2.0		 6czmA-1zq1A:
22.69
6czmC-1zq1A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3g ALPHA-AMYLASE G-6

(Bacillus
halodurans) 		PF16738
(CBM26) 		5 GLY A   6
THR A  27
VAL A  60
VAL A  31
LEU A  22
 None
 1.11A 6czmA-2c3gA:
undetectable
6czmC-2c3gA:
undetectable		 6czmA-2c3gA:
14.46
6czmC-2c3gA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dch PUTATIVE HOMING
ENDONUCLEASE

(Thermoproteus) 		PF14528
(LAGLIDADG_3) 		5 GLY X 107
VAL X 109
VAL X 172
ALA X 168
LEU X 175
 None
 1.03A 6czmA-2dchX:
undetectable
6czmC-2dchX:
undetectable		 6czmA-2dchX:
21.69
6czmC-2dchX:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE

(Pyrococcus
horikoshii) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		5 LEU A 130
VAL A  87
VAL A 115
ALA A  83
LEU A  90
 None
 1.11A 6czmA-2djzA:
2.9
6czmC-2djzA:
undetectable		 6czmA-2djzA:
22.80
6czmC-2djzA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eih ALCOHOL
DEHYDROGENASE

(Thermus
thermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 172
VAL A 158
VAL A 179
ALA A 154
LEU A 162
 None
 0.95A 6czmA-2eihA:
undetectable
6czmC-2eihA:
undetectable		 6czmA-2eihA:
22.67
6czmC-2eihA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f43 ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 GLY A  58
VAL A  53
VAL A  41
VAL A  75
ALA A  39
 None
 1.04A 6czmA-2f43A:
undetectable
6czmC-2f43A:
undetectable		 6czmA-2f43A:
23.18
6czmC-2f43A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imz ENDONUCLEASE PI-MTUI

(Mycobacterium
tuberculosis) 		no annotation 5 GLY A  58
LEU A  59
THR A   6
VAL A 438
ALA A 433
 None
 0.95A 6czmA-2imzA:
undetectable
6czmC-2imzA:
undetectable		 6czmA-2imzA:
18.08
6czmC-2imzA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lmc DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Escherichia
coli) 		no annotation 5 GLY B  72
ASN B  68
VAL B  75
ALA B  28
LEU B  46
 None
 1.05A 6czmA-2lmcB:
undetectable
6czmC-2lmcB:
undetectable		 6czmA-2lmcB:
12.25
6czmC-2lmcB:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oga TRANSAMINASE

(Streptomyces
venezuelae) 		PF01041
(DegT_DnrJ_EryC1) 		5 GLY A  77
LEU A  78
THR A 103
VAL A  86
ALA A 105
 None
 1.09A 6czmA-2ogaA:
undetectable
6czmC-2ogaA:
undetectable		 6czmA-2ogaA:
24.94
6czmC-2ogaA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0a SYNAPSIN-3

(Homo sapiens) 		PF02078
(Synapsin)
PF02750
(Synapsin_C) 		5 LEU A 129
VAL A 164
VAL A 181
ALA A 168
LEU A 184
 None
 1.12A 6czmA-2p0aA:
2.7
6czmC-2p0aA:
undetectable		 6czmA-2p0aA:
23.76
6czmC-2p0aA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ql3 PROBABLE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF03466
(LysR_substrate) 		5 GLY A 180
THR A 248
VAL A 178
VAL A 203
ALA A 237
 None
 1.04A 6czmA-2ql3A:
8.4
6czmC-2ql3A:
7.5		 6czmA-2ql3A:
21.99
6czmC-2ql3A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq6 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Rubrobacter
xylanophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 295
LEU A 296
VAL A  64
ALA A 100
LEU A 375
 None
 1.04A 6czmA-2qq6A:
undetectable
6czmC-2qq6A:
undetectable		 6czmA-2qq6A:
23.19
6czmC-2qq6A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz5 TAX1-BINDING PROTEIN
3

(Homo sapiens) 		PF00595
(PDZ) 		5 LEU A  97
VAL A  57
VAL A  16
ALA A  66
LEU A 107
 None
 1.12A 6czmA-2vz5A:
undetectable
6czmC-2vz5A:
undetectable		 6czmA-2vz5A:
18.42
6czmC-2vz5A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we8 XANTHINE
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF02625
(XdhC_CoxI)
PF13478
(XdhC_C) 		5 GLY A  10
LEU A   9
VAL A  15
VAL A  43
LEU A 114
 None
 1.05A 6czmA-2we8A:
undetectable
6czmC-2we8A:
undetectable		 6czmA-2we8A:
24.07
6czmC-2we8A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we8 XANTHINE
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF02625
(XdhC_CoxI)
PF13478
(XdhC_C) 		6 GLY A 171
LEU A 172
VAL A 196
VAL A 147
ALA A 130
LEU A 181
 None
 1.01A 6czmA-2we8A:
undetectable
6czmC-2we8A:
undetectable		 6czmA-2we8A:
24.07
6czmC-2we8A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wt8 MICROCEPHALIN

(Homo sapiens) 		PF12738
(PTCB-BRCT) 		5 VAL A  71
VAL A   9
VAL A  13
ALA A  11
LEU A   6
 None
 1.08A 6czmA-2wt8A:
undetectable
6czmC-2wt8A:
undetectable		 6czmA-2wt8A:
14.76
6czmC-2wt8A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1q ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 GLY A 410
LEU A 412
VAL A 460
VAL A 472
ALA A 464
 None
 0.90A 6czmA-2z1qA:
undetectable
6czmC-2z1qA:
undetectable		 6czmA-2z1qA:
21.47
6czmC-2z1qA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuf ARGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		5 GLY A 156
LEU A 155
VAL A 159
ALA A 149
LEU A 620
 None
 1.06A 6czmA-2zufA:
undetectable
6czmC-2zufA:
undetectable		 6czmA-2zufA:
21.50
6czmC-2zufA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2f DNA POLYMERASE

(Pyrococcus
furiosus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 LEU A 545
VAL A 565
VAL A 402
ALA A 561
LEU A 578
 None
 1.03A 6czmA-3a2fA:
3.8
6czmC-3a2fA:
undetectable		 6czmA-3a2fA:
18.84
6czmC-3a2fA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aam ENDONUCLEASE IV

(Thermus
thermophilus) 		PF01261
(AP_endonuc_2) 		5 GLY A 120
VAL A 105
VAL A  74
ALA A  70
LEU A 136
 None
 1.01A 6czmA-3aamA:
undetectable
6czmC-3aamA:
undetectable		 6czmA-3aamA:
21.92
6czmC-3aamA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5e MLL8374 PROTEIN

(Mesorhizobium
japonicum) 		no annotation 5 LEU A 181
THR A 160
VAL A 189
ALA A 187
LEU A 129
 None
 1.01A 6czmA-3b5eA:
undetectable
6czmC-3b5eA:
undetectable		 6czmA-3b5eA:
22.49
6czmC-3b5eA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj1 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 2

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		5 LEU A 100
THR A  51
VAL A 143
VAL A  77
LEU A 147
 None
 1.14A 6czmA-3cj1A:
undetectable
6czmC-3cj1A:
undetectable		 6czmA-3cj1A:
24.63
6czmC-3cj1A:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Enterococcus
faecalis) 		PF13377
(Peripla_BP_3) 		5 GLY A 111
VAL A  64
VAL A 135
ALA A 290
LEU A  85
 None
 1.00A 6czmA-3cs3A:
undetectable
6czmC-3cs3A:
undetectable		 6czmA-3cs3A:
24.38
6czmC-3cs3A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czb PUTATIVE
TRANSGLYCOSYLASE

(Caulobacter
vibrioides) 		PF03562
(MltA)
PF06725
(3D) 		5 GLY A 223
LEU A 217
VAL A 233
ALA A 143
LEU A 155
 None
 1.01A 6czmA-3czbA:
undetectable
6czmC-3czbA:
undetectable		 6czmA-3czbA:
22.75
6czmC-3czbA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3y UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF05193
(Peptidase_M16_C) 		5 LEU A 327
VAL A 314
VAL A 291
ALA A 301
LEU A 256
 None
 1.13A 6czmA-3d3yA:
undetectable
6czmC-3d3yA:
undetectable		 6czmA-3d3yA:
22.87
6czmC-3d3yA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2v 3'-5'-EXONUCLEASE

(Saccharomyces
cerevisiae) 		PF01026
(TatD_DNase) 		5 GLY A  42
LEU A  43
VAL A  96
ALA A  92
LEU A 107
 None
 0.92A 6czmA-3e2vA:
undetectable
6czmC-3e2vA:
undetectable		 6czmA-3e2vA:
21.75
6czmC-3e2vA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gka N-ETHYLMALEIMIDE
REDUCTASE

(Burkholderia
pseudomallei) 		PF00724
(Oxidored_FMN) 		5 GLY A 111
LEU A 187
THR A  68
VAL A  67
ALA A 162
 None
 1.01A 6czmA-3gkaA:
undetectable
6czmC-3gkaA:
undetectable		 6czmA-3gkaA:
21.54
6czmC-3gkaA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hee RIBOSE-5-PHOSPHATE
ISOMERASE

(Ruminiclostridium
thermocellum) 		PF02502
(LacAB_rpiB) 		5 GLY A  68
VAL A 120
VAL A 111
ALA A 116
LEU A 104
 None
 1.14A 6czmA-3heeA:
2.5
6czmC-3heeA:
3.4		 6czmA-3heeA:
18.86
6czmC-3heeA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igd ENDONUCLEASE PI-MTUI

(Mycobacterium
tuberculosis) 		no annotation 5 GLY A  58
LEU A  59
THR A   6
VAL A 438
ALA A 433
 None
 0.96A 6czmA-3igdA:
undetectable
6czmC-3igdA:
undetectable		 6czmA-3igdA:
16.76
6czmC-3igdA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Ruegeria
pomeroyi) 		PF00356
(LacI)
PF00532
(Peripla_BP_1) 		5 GLY A 125
VAL A  71
VAL A 149
ALA A 307
LEU A  92
 None
 1.01A 6czmA-3kjxA:
undetectable
6czmC-3kjxA:
undetectable		 6czmA-3kjxA:
24.62
6czmC-3kjxA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5

(Homo sapiens) 		PF01094
(ANF_receptor) 		5 GLY A 285
LEU A 286
THR A 314
VAL A 313
ALA A 321
 None
 1.12A 6czmA-3lmkA:
undetectable
6czmC-3lmkA:
undetectable		 6czmA-3lmkA:
21.04
6czmC-3lmkA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myb ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		5 GLY A 165
VAL A 168
VAL A 153
ALA A 157
LEU A 149
 None
 1.07A 6czmA-3mybA:
undetectable
6czmC-3mybA:
undetectable		 6czmA-3mybA:
23.58
6czmC-3mybA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odt PROTEIN DOA1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 GLY A  80
LEU A  70
VAL A  22
VAL A  36
ALA A  28
 None
 0.76A 6czmA-3odtA:
undetectable
6czmC-3odtA:
undetectable		 6czmA-3odtA:
23.53
6czmC-3odtA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqv ALBC

(Streptomyces
noursei) 		PF16715
(CDPS) 		5 LEU A 122
THR A  69
VAL A  67
ALA A 181
LEU A 185
 None
None
None
PO4  A 250 ( 3.7A)
DTD  A 248 ( 4.9A)
 1.03A 6czmA-3oqvA:
undetectable
6czmC-3oqvA:
undetectable		 6czmA-3oqvA:
22.07
6czmC-3oqvA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 5 GLY A 269
LEU A 267
VAL A 240
VAL A 227
LEU A 261
 None
 1.08A 6czmA-3p4gA:
undetectable
6czmC-3p4gA:
undetectable		 6czmA-3p4gA:
20.54
6czmC-3p4gA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pk0 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 GLY A 136
VAL A   9
VAL A 139
ALA A 225
LEU A   4
 None
 1.10A 6czmA-3pk0A:
undetectable
6czmC-3pk0A:
undetectable		 6czmA-3pk0A:
24.66
6czmC-3pk0A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pow CALRETICULIN

(Homo sapiens) 		PF00262
(Calreticulin) 		5 GLY A  65
LEU A  66
THR A 325
VAL A  97
LEU A 316
 CA  A 900 ( 4.9A)
None
None
None
None
 1.09A 6czmA-3powA:
undetectable
6czmC-3powA:
undetectable		 6czmA-3powA:
21.66
6czmC-3powA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ruc WBGU

(Plesiomonas
shigelloides) 		PF01370
(Epimerase) 		5 GLY A  45
THR A  18
VAL A  42
CYH A  73
VAL A  92
 None
 1.04A 6czmA-3rucA:
undetectable
6czmC-3rucA:
undetectable		 6czmA-3rucA:
23.86
6czmC-3rucA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3su8 PLEXIN-B1

(Homo sapiens) 		PF08337
(Plexin_cytopl) 		5 GLY X1844
VAL X1841
VAL X1805
VAL X1771
ALA X1780
 None
 1.14A 6czmA-3su8X:
undetectable
6czmC-3su8X:
undetectable		 6czmA-3su8X:
21.61
6czmC-3su8X:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5n OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 GLY A  23
LEU A  49
VAL A  94
ALA A  92
LEU A  44
 None
 1.07A 6czmA-3v5nA:
undetectable
6czmC-3v5nA:
undetectable		 6czmA-3v5nA:
22.97
6czmC-3v5nA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vex O-CARBAMOYLTRANSFERA
SE TOBZ

(Streptoalloteichus
tenebrarius) 		PF02543
(Carbam_trans_N)
PF16861
(Carbam_trans_C) 		5 LEU A 343
VAL A   3
VAL A 112
ALA A  68
LEU A  21
 None
 1.15A 6czmA-3vexA:
undetectable
6czmC-3vexA:
undetectable		 6czmA-3vexA:
21.96
6czmC-3vexA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzb SPHINGOSINE KINASE 1

(Homo sapiens) 		PF00781
(DAGK_cat) 		5 GLY A 172
LEU A 259
THR A 205
ALA A 292
LEU A 299
 EDO  A 406 (-3.4A)
None
None
None
None
 1.00A 6czmA-3vzbA:
undetectable
6czmC-3vzbA:
undetectable		 6czmA-3vzbA:
23.62
6czmC-3vzbA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zvt D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Actinomadura
sp. R39) 		PF02113
(Peptidase_S13) 		5 LEU A  53
VAL A 361
VAL A 436
ALA A 357
LEU A 364
 None
 1.15A 6czmA-3zvtA:
undetectable
6czmC-3zvtA:
1.4		 6czmA-3zvtA:
21.62
6czmC-3zvtA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF00111
(Fer2)
PF14574
(DUF4445) 		6 GLY X  62
LEU X  64
THR X  79
VAL X  49
VAL X  58
LEU X  48
 None
 1.40A 6czmA-3zyyX:
undetectable
6czmC-3zyyX:
undetectable		 6czmA-3zyyX:
21.98
6czmC-3zyyX:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aj9 CATALASE-3

(Neurospora
crassa) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 GLY A 648
VAL A 634
VAL A 627
ALA A 673
LEU A 574
 1PE  A1723 ( 4.1A)
None
None
None
None
 1.16A 6czmA-4aj9A:
undetectable
6czmC-4aj9A:
undetectable		 6czmA-4aj9A:
20.93
6czmC-4aj9A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvg DIAPHANOUS PROTEIN

(Entamoeba
histolytica) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		5 GLY B 222
LEU B 226
VAL B 206
ALA B 212
LEU B 203
 None
 1.12A 6czmA-4dvgB:
undetectable
6czmC-4dvgB:
undetectable		 6czmA-4dvgB:
21.15
6czmC-4dvgB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE

(Escherichia
coli) 		PF00378
(ECH_1) 		5 CYH A 108
VAL A 157
VAL A 148
ALA A 153
LEU A 127
 None
 1.02A 6czmA-4fzwA:
undetectable
6czmC-4fzwA:
undetectable		 6czmA-4fzwA:
22.46
6czmC-4fzwA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha6 PYRIDOXINE 4-OXIDASE

(Mesorhizobium
loti) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A 425
LEU A 430
VAL A 322
ALA A 318
LEU A 169
 None
 0.99A 6czmA-4ha6A:
undetectable
6czmC-4ha6A:
undetectable		 6czmA-4ha6A:
22.08
6czmC-4ha6A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbz PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE, SIXA

(Nakamurella
multipartita) 		PF00300
(His_Phos_1) 		5 GLY A  50
LEU A  53
VAL A  63
ALA A  82
LEU A 113
 None
 1.16A 6czmA-4hbzA:
undetectable
6czmC-4hbzA:
undetectable		 6czmA-4hbzA:
19.38
6czmC-4hbzA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1

(Homo sapiens) 		PF03493
(BK_channel_a) 		5 GLY A 825
LEU A 822
THR A 863
VAL A 799
ALA A 817
 None
 1.15A 6czmA-4hpfA:
2.3
6czmC-4hpfA:
undetectable		 6czmA-4hpfA:
19.10
6czmC-4hpfA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imm OUTER MEMBRANE
ASSEMBLY LIPOPROTEIN
YFGL

(Moraxella
catarrhalis) 		PF13360
(PQQ_2) 		5 GLY A 131
LEU A 149
VAL A 164
ALA A 157
LEU A 176
 None
None
None
NA  A 404 (-4.5A)
None
 1.09A 6czmA-4immA:
undetectable
6czmC-4immA:
undetectable		 6czmA-4immA:
22.12
6czmC-4immA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2

(Homo sapiens) 		PF00561
(Abhydrolase_1) 		5 GLY A 337
LEU A 340
CYH A 264
VAL A 352
ALA A 345
 None
 1.13A 6czmA-4jncA:
undetectable
6czmC-4jncA:
undetectable		 6czmA-4jncA:
21.56
6czmC-4jncA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN

(Acidaminococcus
fermentans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 THR A 139
CYH A 217
VAL A 168
ALA A 170
LEU A 186
 None
 1.09A 6czmA-4l1fA:
undetectable
6czmC-4l1fA:
undetectable		 6czmA-4l1fA:
22.04
6czmC-4l1fA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lza ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermoanaerobacter
pseudethanolicus) 		PF00156
(Pribosyltran) 		5 GLY A 139
LEU A 138
VAL A  78
VAL A 115
ALA A  54
 None
 0.84A 6czmA-4lzaA:
undetectable
6czmC-4lzaA:
undetectable		 6czmA-4lzaA:
21.08
6czmC-4lzaA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m38 PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Trypanosoma
brucei) 		PF06325
(PrmA) 		5 LEU A 109
VAL A  99
VAL A 147
ALA A 114
LEU A  89
 SAH  A 401 (-3.9A)
None
None
None
None
 1.01A 6czmA-4m38A:
undetectable
6czmC-4m38A:
undetectable		 6czmA-4m38A:
22.79
6czmC-4m38A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5h PHENYLACETALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 GLY A 213
LEU A 215
VAL A 124
ALA A 127
LEU A 104
 None
 1.11A 6czmA-4o5hA:
undetectable
6czmC-4o5hA:
undetectable		 6czmA-4o5hA:
23.08
6czmC-4o5hA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0g PROBABLE
ACETYL-/PROPIONYL-CO
A CARBOXYLASE (BETA
SUBUNIT) ACCD1

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		5 GLY A  84
THR A  87
VAL A 100
ALA A 122
LEU A 492
 None
 1.08A 6czmA-4q0gA:
undetectable
6czmC-4q0gA:
undetectable		 6czmA-4q0gA:
21.56
6czmC-4q0gA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q48 DNA HELICASE RECQ

(Deinococcus
radiodurans) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		5 GLY A 442
LEU A 441
THR A 458
VAL A 461
ALA A 423
 None
 1.11A 6czmA-4q48A:
undetectable
6czmC-4q48A:
undetectable		 6czmA-4q48A:
23.33
6czmC-4q48A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvs PROBABLE QUINONE
REDUCTASE QOR
(NADPH:QUINONE
REDUCTASE)
(ZETA-CRYSTALLIN
HOMOLOG PROTEIN)

(Mycobacterium
tuberculosis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 182
THR A 172
VAL A 191
ALA A 188
LEU A 157
 None
 1.12A 6czmA-4rvsA:
undetectable
6czmC-4rvsA:
undetectable		 6czmA-4rvsA:
23.56
6czmC-4rvsA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT

(Desulfovibrio
vulgaris) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 GLY S  77
VAL S  74
VAL S 142
ALA S 144
LEU S 137
 None
 1.11A 6czmA-4u9iS:
undetectable
6czmC-4u9iS:
undetectable		 6czmA-4u9iS:
23.60
6czmC-4u9iS:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwv AMINOPEPTIDASE FROM
FAMILY M42

(Desulfurococcus
amylolyticus) 		PF05343
(Peptidase_M42) 		5 LEU A  36
VAL A  29
VAL A 189
VAL A  52
ALA A 210
 None
 1.03A 6czmA-4wwvA:
undetectable
6czmC-4wwvA:
undetectable		 6czmA-4wwvA:
25.00
6czmC-4wwvA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zu9 ELONGATION FACTOR
SELB

(Aquifex
aeolicus) 		PF00009
(GTP_EFTU)
PF09107
(SelB-wing_3) 		5 GLY A 297
VAL A 338
VAL A 325
ALA A 336
LEU A 272
 None
 1.12A 6czmA-4zu9A:
undetectable
6czmC-4zu9A:
undetectable		 6czmA-4zu9A:
23.71
6czmC-4zu9A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8c UL34 PROTEIN

(Suid
alphaherpesvirus
1) 		PF04541
(Herpes_U34) 		5 GLY B  84
VAL B  73
VAL B 139
VAL B  40
LEU B  52
 None
 1.16A 6czmA-5e8cB:
undetectable
6czmC-5e8cB:
undetectable		 6czmA-5e8cB:
20.99
6czmC-5e8cB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE

(Trypanosoma
brucei) 		PF06325
(PrmA) 		5 LEU A 109
VAL A  99
VAL A 147
ALA A 114
LEU A  89
 SAH  A 401 (-3.9A)
None
None
None
None
 0.98A 6czmA-5ekuA:
undetectable
6czmC-5ekuA:
undetectable		 6czmA-5ekuA:
22.25
6czmC-5ekuA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fno MANGANESE
LIPOXYGENASE

(Magnaporthe
oryzae) 		PF00305
(Lipoxygenase) 		5 GLY A 280
LEU A 277
VAL A 164
ALA A 480
LEU A 523
 None
 1.15A 6czmA-5fnoA:
undetectable
6czmC-5fnoA:
undetectable		 6czmA-5fnoA:
21.32
6czmC-5fnoA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyd OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Collinsella
aerofaciens) 		PF00106
(adh_short) 		5 THR A  75
CYH A 122
VAL A  38
ALA A  65
LEU A  14
 None
 1.09A 6czmA-5fydA:
undetectable
6czmC-5fydA:
undetectable		 6czmA-5fydA:
20.49
6czmC-5fydA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Paraburkholderia
phymatum) 		PF00106
(adh_short) 		5 GLY A 117
THR A  62
VAL A  10
ALA A  36
LEU A  87
 None
 0.86A 6czmA-5ig2A:
undetectable
6czmC-5ig2A:
undetectable		 6czmA-5ig2A:
24.18
6czmC-5ig2A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL

(Rhodoferax
ferrireducens) 		PF03480
(DctP) 		5 GLY A 181
LEU A 183
VAL A 176
ALA A 208
LEU A 236
 None
 0.88A 6czmA-5im2A:
4.7
6czmC-5im2A:
4.4		 6czmA-5im2A:
22.74
6czmC-5im2A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum) 		PF12708
(Pectate_lyase_3) 		5 GLY A 534
LEU A 535
VAL A 623
VAL A 615
LEU A 576
 None
 0.95A 6czmA-5m60A:
undetectable
6czmC-5m60A:
undetectable		 6czmA-5m60A:
20.08
6czmC-5m60A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msw THIOESTER REDUCTASE
DOMAIN-CONTAINING
PROTEIN

(Segniliparus
rugosus) 		PF00501
(AMP-binding)
PF00550
(PP-binding) 		5 GLY A 699
LEU A 698
VAL A 674
ALA A 677
LEU A 732
 None
 1.15A 6czmA-5mswA:
2.2
6czmC-5mswA:
1.9		 6czmA-5mswA:
15.94
6czmC-5mswA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3z SORBITOL-6-PHOSPHATE
DEHYDROGENASE

(Erwinia
amylovora) 		no annotation 5 GLY A 115
VAL A   6
VAL A  60
ALA A  32
LEU A  85
 None
 0.99A 6czmA-5o3zA:
undetectable
6czmC-5o3zA:
undetectable		 6czmA-5o3zA:
undetectable
6czmC-5o3zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 5 GLY A 203
LEU A 202
VAL A 209
ALA A 115
LEU A 273
 None
 1.14A 6czmA-5u94A:
undetectable
6czmC-5u94A:
undetectable		 6czmA-5u94A:
undetectable
6czmC-5u94A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u99 ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF01634
(HisG)
PF08029
(HisG_C) 		5 LEU A  48
THR A  67
VAL A  57
ALA A  54
LEU A  62
 None
 0.97A 6czmA-5u99A:
23.3
6czmC-5u99A:
22.8		 6czmA-5u99A:
28.94
6czmC-5u99A:
28.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 SMALL NUCLEAR
RIBONUCLEOPROTEIN G

(Saccharomyces
cerevisiae) 		no annotation 5 GLY Q  31
LEU Q  29
THR Q  61
ALA Q  43
LEU Q  17
 None
 0.90A 6czmA-5uz5Q:
undetectable
6czmC-5uz5Q:
undetectable		 6czmA-5uz5Q:
14.03
6czmC-5uz5Q:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 SMALL NUCLEAR
RIBONUCLEOPROTEIN G

(Saccharomyces
cerevisiae) 		no annotation 5 LEU Q  29
THR Q  61
VAL Q  25
ALA Q  43
LEU Q  17
 None
 0.81A 6czmA-5uz5Q:
undetectable
6czmC-5uz5Q:
undetectable		 6czmA-5uz5Q:
14.03
6czmC-5uz5Q:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8d AUTOINDUCER SYNTHASE

(Bradyrhizobium
japonicum) 		PF00765
(Autoind_synth) 		5 CYH A 127
VAL A  54
VAL A 193
ALA A   4
LEU A  70
 None
 1.09A 6czmA-5w8dA:
undetectable
6czmC-5w8dA:
undetectable		 6czmA-5w8dA:
19.94
6czmC-5w8dA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei) 		no annotation 5 GLY A 176
LEU A 174
VAL A 124
ALA A 128
LEU A 121
 None
 1.02A 6czmA-5xwqA:
undetectable
6czmC-5xwqA:
undetectable		 6czmA-5xwqA:
undetectable
6czmC-5xwqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blb HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB

(Pseudomonas
aeruginosa) 		no annotation 5 GLY A 202
LEU A 201
VAL A 231
ALA A 235
LEU A 228
 None
 1.02A 6czmA-6blbA:
undetectable
6czmC-6blbA:
undetectable		 6czmA-6blbA:
24.94
6czmC-6blbA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwt THIOREDOXIN
REDUCTASE

(Francisella
tularensis) 		no annotation 5 LEU A 179
THR A 155
VAL A 149
ALA A 240
LEU A 172
 None
SO4  A 403 (-3.4A)
None
None
None
 1.10A 6czmA-6bwtA:
undetectable
6czmC-6bwtA:
undetectable		 6czmA-6bwtA:
undetectable
6czmC-6bwtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2

(Candidatus
Methanoperedens
nitroreducens) 		no annotation 5 GLY A 257
VAL A 279
VAL A 307
ALA A 221
LEU A 308
 None
 1.09A 6czmA-6bxnA:
undetectable
6czmC-6bxnA:
undetectable		 6czmA-6bxnA:
undetectable
6czmC-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA

(Naegleria
fowleri) 		no annotation 5 THR A 182
VAL A 145
VAL A 178
ALA A 141
LEU A 148
 None
 1.11A 6czmA-6c87A:
2.2
6czmC-6c87A:
1.8		 6czmA-6c87A:
undetectable
6czmC-6c87A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH SUBUNIT
MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C

(Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus) 		no annotation
no annotation
no annotation
no annotation 		6 GLY G  86
CYH G  88
VAL F 129
VAL D  72
ALA F  43
LEU E  79
 None
 1.42A 6czmA-6cfwG:
undetectable
6czmC-6cfwG:
undetectable		 6czmA-6cfwG:
undetectable
6czmC-6cfwG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czm -

(-) 		no annotation 5 GLY A 300
LEU A 301
THR A 305
VAL A 325
CYH A 327
 HIS  A 402 (-3.4A)
HIS  A 402 (-4.0A)
HIS  A 402 (-4.2A)
HIS  A 402 (-4.4A)
HIS  A 402 (-4.2A)
 0.00A 6czmA-6czmA:
46.0
6czmC-6czmA:
41.8		 6czmA-6czmA:
undetectable
6czmC-6czmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czm -

(-) 		no annotation 5 VAL A 277
ASN A 279
VAL A 309
ALA A 323
LEU A 349
 None
 0.10A 6czmA-6czmA:
46.0
6czmC-6czmA:
41.8		 6czmA-6czmA:
undetectable
6czmC-6czmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fiv RETROPEPSIN

(Feline
immunodeficiency
virus) 		PF00077
(RVP) 		5 GLY A 103
LEU A 102
VAL A  89
VAL A  20
LEU A  73
 None
 1.11A 6czmA-6fivA:
undetectable
6czmC-6fivA:
undetectable		 6czmA-6fivA:
14.49
6czmC-6fivA:
14.49