SIMILAR PATTERNS OF AMINO ACIDS FOR 6CR0_A_ACTA506

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9g HYPOTHETICAL PROTEIN
RV2118C

(Mycobacterium
tuberculosis) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		4 ALA A 204
HIS A 251
TYR A  84
LYS A  86
 None
 1.23A 6cr0A-1i9gA:
2.2		 6cr0A-1i9gA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8a INOSITOL
POLYPHOSPHATE
MULTIKINASE

(Homo sapiens) 		no annotation 4 ALA A 250
HIS A 388
TYR A 152
LYS A 160
 None
 1.28A 6cr0A-6c8aA:
0.0		 6cr0A-6c8aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cr0 (S)-6-HYDROXYNICOTIN
E OXIDASE

(Shinella sp.
HZN7) 		no annotation 4 ALA A  82
HIS A 205
TYR A 320
LYS A 331
 ACT  A 506 ( 3.8A)
ACT  A 506 (-4.0A)
ACT  A 506 (-4.7A)
None
 0.00A 6cr0A-6cr0A:
73.3		 6cr0A-6cr0A:
undetectable