SIMILAR PATTERNS OF AMINO ACIDS FOR 6CNK_D_NCTD401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bj0 ACETYLCHOLINE-BINDIN
G PROTEIN


(Bulinus
truncatus)
PF02931
(Neur_chan_LBD)
5 TYR A  88
TRP A 142
THR A 143
TYR A 184
TYR A 191
None
CXS  A1204 (-3.6A)
CXS  A1204 ( 4.7A)
CXS  A1204 (-4.6A)
CXS  A1204 (-4.7A)
0.84A 6cnkD-2bj0A:
21.3
6cnkE-2bj0A:
9.9
6cnkD-2bj0A:
17.44
6cnkE-2bj0A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdh ACETYLCHOLINE
BINDING PROTEIN


(Lymnaea
stagnalis)
PF02931
(Neur_chan_LBD)
5 TYR A  89
TRP A 143
THR A 144
TYR A 185
TYR A 192
None
XRS  A 301 (-3.6A)
XRS  A 301 ( 4.4A)
XRS  A 301 ( 4.1A)
XRS  A 301 (-3.8A)
0.57A 6cnkD-3zdhA:
20.5
6cnkE-3zdhA:
21.2
6cnkD-3zdhA:
19.17
6cnkE-3zdhA:
17.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fjv NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-2


(Homo sapiens)
PF02931
(Neur_chan_LBD)
5 TYR A 122
TRP A 178
THR A 179
TYR A 219
TYR A 226
EPJ  A 300 (-4.6A)
EPJ  A 300 (-3.7A)
EPJ  A 300 (-3.3A)
EPJ  A 300 (-3.7A)
EPJ  A 300 (-3.7A)
0.75A 6cnkD-5fjvA:
23.4
6cnkE-5fjvA:
24.1
6cnkD-5fjvA:
59.38
6cnkE-5fjvA:
21.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kxi NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4


(Homo sapiens)
PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb)
5 TYR A 100
TRP A 156
THR A 157
TYR A 197
TYR A 204
NCT  A 402 (-4.8A)
NCT  A 402 (-3.9A)
NCT  A 402 (-4.6A)
NCT  A 402 ( 4.9A)
NCT  A 402 (-3.8A)
0.60A 6cnkD-5kxiA:
36.5
6cnkE-5kxiA:
34.3
6cnkD-5kxiA:
100.00
6cnkE-5kxiA:
12.96