SIMILAR PATTERNS OF AMINO ACIDS FOR 6CM4_A_8NUA2001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3z BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF00232
(Glyco_hydro_1) 		5 PHE A 147
VAL A 209
SER A 293
PHE A 295
THR A 120
 None
 1.20A 6cm4A-2e3zA:
undetectable		 6cm4A-2e3zA:
22.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		8 PHE A 106
VAL A 111
THR A 115
PHE A 338
TRP A 342
PHE A 346
THR A 369
TYR A 373
 ETQ  A1200 (-4.8A)
ETQ  A1200 (-3.4A)
None
None
None
ETQ  A1200 ( 4.5A)
ETQ  A1200 (-4.5A)
ETQ  A1200 (-4.4A)
 0.69A 6cm4A-3pblA:
38.3		 6cm4A-3pblA:
74.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 VAL A 111
CYH A 114
THR A 115
TRP A 342
THR A 369
 ETQ  A1200 (-3.4A)
ETQ  A1200 (-4.0A)
None
None
ETQ  A1200 (-4.5A)
 1.16A 6cm4A-3pblA:
38.3		 6cm4A-3pblA:
74.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 VAL A 111
CYH A 114
THR A 115
TRP A 342
TYR A 365
 ETQ  A1200 (-3.4A)
ETQ  A1200 (-4.0A)
None
None
None
 1.34A 6cm4A-3pblA:
38.3		 6cm4A-3pblA:
74.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 VAL A 111
SER A 192
PHE A 338
TRP A 342
PHE A 346
 ETQ  A1200 (-3.4A)
ETQ  A1200 (-3.3A)
None
None
ETQ  A1200 ( 4.5A)
 0.98A 6cm4A-3pblA:
38.3		 6cm4A-3pblA:
74.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 VAL A 111
THR A 115
PHE A 338
TRP A 342
PHE A 346
TYR A 365
 ETQ  A1200 (-3.4A)
None
None
None
ETQ  A1200 ( 4.5A)
None
 0.90A 6cm4A-3pblA:
38.3		 6cm4A-3pblA:
74.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 PHE A 282
TRP A 286
PHE A 290
TYR A 308
TYR A 316
 None
None
ERC  A1201 (-4.8A)
None
None
 0.84A 6cm4A-3pdsA:
35.8		 6cm4A-3pdsA:
57.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 SER A 203
PHE A 282
TRP A 286
PHE A 290
TYR A 308
 ERC  A1201 (-2.8A)
None
None
ERC  A1201 (-4.8A)
None
 1.06A 6cm4A-3pdsA:
35.8		 6cm4A-3pdsA:
57.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 VAL A 114
THR A 118
PHE A 282
TRP A 286
PHE A 290
TYR A 316
 ERC  A1201 (-3.8A)
None
None
None
ERC  A1201 (-4.8A)
None
 0.73A 6cm4A-3pdsA:
35.8		 6cm4A-3pdsA:
57.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 VAL A 114
THR A 118
SER A 203
PHE A 282
TRP A 286
PHE A 290
 ERC  A1201 (-3.8A)
None
ERC  A1201 (-2.8A)
None
None
ERC  A1201 (-4.8A)
 0.92A 6cm4A-3pdsA:
35.8		 6cm4A-3pdsA:
57.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 THR A 112
PHE A 424
TRP A 428
PHE A 432
TYR A 458
 D7V  A1201 ( 4.0A)
None
5EH  A1200 ( 3.4A)
5EH  A1200 ( 4.3A)
5EH  A1200 ( 4.4A)
 0.55A 6cm4A-3rzeA:
37.3		 6cm4A-3rzeA:
58.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		5 PHE A 254
TRP A 258
PHE A 262
TYR A 280
TYR A 288
 None
None
CAU  A 500 (-4.6A)
None
CAU  A 500 (-4.6A)
 0.64A 6cm4A-4gbrA:
30.5		 6cm4A-4gbrA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		6 VAL A 114
THR A 118
PHE A 254
TRP A 258
PHE A 262
TYR A 288
 CAU  A 500 (-3.5A)
CAU  A 500 ( 4.7A)
None
None
CAU  A 500 (-4.6A)
CAU  A 500 (-4.6A)
 0.74A 6cm4A-4gbrA:
30.5		 6cm4A-4gbrA:
25.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		6 VAL A 136
THR A 140
PHE A 333
TRP A 337
PHE A 341
TYR A 370
 ERM  A2001 (-3.8A)
ERM  A2001 (-3.9A)
None
None
None
ERM  A2001 ( 4.8A)
 1.03A 6cm4A-4ib4A:
26.9		 6cm4A-4ib4A:
30.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 VAL A1114
THR A1118
SER A1203
TRP A1286
PHE A1290
 P0G  A1401 (-3.7A)
None
P0G  A1401 (-2.9A)
None
P0G  A1401 ( 4.9A)
 1.02A 6cm4A-4ldeA:
26.7		 6cm4A-4ldeA:
32.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 VAL A1114
THR A1118
TRP A1286
PHE A1290
TYR A1316
 P0G  A1401 (-3.7A)
None
None
P0G  A1401 ( 4.9A)
None
 0.65A 6cm4A-4ldeA:
26.7		 6cm4A-4ldeA:
32.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7f FIBRINOGEN C
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		5 TRP A 410
PHE A 350
VAL A 333
SER A 450
TYR A 302
 None
 1.37A 6cm4A-4m7fA:
undetectable		 6cm4A-4m7fA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi6 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		5 VAL A 537
THR A 613
SER A 605
TYR A 619
THR A 599
 None
 1.34A 6cm4A-4qi6A:
undetectable		 6cm4A-4qi6A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9j FICOLIN-2

(Homo sapiens) 		no annotation 5 TRP G 241
PHE G 185
VAL G 168
SER G 281
TYR G 137
 None
 1.42A 6cm4A-4r9jG:
undetectable		 6cm4A-4r9jG:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 2

(Homo sapiens;
Homo sapiens) 		PF12859
(ANAPC1)
PF00888
(Cullin)
PF08672
(ANAPC2) 		5 VAL A1848
CYH A1850
THR A1851
PHE N 163
THR N 155
 None
 1.41A 6cm4A-5a31A:
undetectable		 6cm4A-5a31A:
14.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 6 VAL B 122
THR B 126
PHE B 299
TRP B 303
PHE B 307
TYR B 333
 P32  B 400 (-3.5A)
None
None
None
P32  B 400 (-4.9A)
P32  B 400 (-4.6A)
 0.73A 6cm4A-5f8uB:
30.3		 6cm4A-5f8uB:
30.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B

(Spodoptera
frugiperda;
Homo sapiens) 		no annotation 6 CYH A 133
THR A 134
TRP A 327
PHE A 331
THR A 355
TYR A 359
 89F  A1201 (-4.5A)
89F  A1201 (-4.2A)
89F  A1201 (-3.6A)
89F  A1201 (-4.6A)
89F  A1201 (-4.0A)
None
 0.42A 6cm4A-5v54A:
27.1		 6cm4A-5v54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B

(Spodoptera
frugiperda;
Homo sapiens) 		no annotation 5 THR A 134
PHE A 323
TRP A 327
PHE A 331
THR A 355
 89F  A1201 (-4.2A)
None
89F  A1201 (-3.6A)
89F  A1201 (-4.6A)
89F  A1201 (-4.0A)
 0.79A 6cm4A-5v54A:
27.1		 6cm4A-5v54A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 CYH A 119
THR A 120
SER A 197
TRP A 407
THR A 434
 AQD  A1201 ( 3.9A)
AQD  A1201 (-4.4A)
AQD  A1201 ( 4.0A)
None
AQD  A1201 (-3.5A)
 1.31A 6cm4A-5wivA:
30.5		 6cm4A-5wivA:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 THR A 120
SER A 197
PHE A 403
TRP A 407
THR A 434
 AQD  A1201 (-4.4A)
AQD  A1201 ( 4.0A)
None
None
AQD  A1201 (-3.5A)
 1.00A 6cm4A-5wivA:
30.5		 6cm4A-5wivA:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 VAL A 116
CYH A 119
THR A 120
TRP A 407
THR A 434
 AQD  A1201 ( 3.9A)
AQD  A1201 ( 3.9A)
AQD  A1201 (-4.4A)
None
AQD  A1201 (-3.5A)
 1.14A 6cm4A-5wivA:
30.5		 6cm4A-5wivA:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 6 VAL A 116
PHE A 403
TRP A 407
PHE A 411
THR A 434
TYR A 438
 AQD  A1201 ( 3.9A)
None
None
AQD  A1201 (-4.6A)
AQD  A1201 (-3.5A)
None
 0.68A 6cm4A-5wivA:
30.5		 6cm4A-5wivA:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 VAL A 116
SER A 196
PHE A 403
TRP A 407
PHE A 411
 AQD  A1201 ( 3.9A)
AQD  A1201 (-2.8A)
None
None
AQD  A1201 (-4.6A)
 1.12A 6cm4A-5wivA:
30.5		 6cm4A-5wivA:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 6 VAL A 116
THR A 120
PHE A 403
TRP A 407
THR A 434
TYR A 438
 AQD  A1201 ( 3.9A)
AQD  A1201 (-4.4A)
None
None
AQD  A1201 (-3.5A)
None
 0.40A 6cm4A-5wivA:
30.5		 6cm4A-5wivA:
35.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 5 THR A 139
SER A 219
PHE A 320
TRP A 324
PHE A 328
 E2J  A1201 (-4.3A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.4A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.4A)
 0.95A 6cm4A-6bqhA:
30.7		 6cm4A-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 6 VAL A 135
THR A 139
PHE A 320
TRP A 324
PHE A 328
TYR A 358
 E2J  A1201 (-3.8A)
E2J  A1201 (-4.3A)
E2J  A1201 (-4.4A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.4A)
None
 0.40A 6cm4A-6bqhA:
30.7		 6cm4A-6bqhA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		no annotation 5 SER A 194
PHE A 382
TRP A 386
TYR A 408
THR A 412
 None
8NU  A2001 ( 4.7A)
8NU  A2001 ( 3.8A)
8NU  A2001 ( 4.0A)
8NU  A2001 ( 3.8A)
 0.79A 6cm4A-6cm4A:
55.7		 6cm4A-6cm4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		no annotation 12 TRP A 100
PHE A 110
VAL A 115
CYH A 118
THR A 119
SER A 193
PHE A 382
TRP A 386
PHE A 390
TYR A 408
THR A 412
TYR A 416
 None
8NU  A2001 ( 4.9A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 4.0A)
8NU  A2001 ( 4.4A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.7A)
8NU  A2001 ( 3.8A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.0A)
8NU  A2001 ( 3.8A)
8NU  A2001 ( 4.9A)
 0.00A 6cm4A-6cm4A:
55.7		 6cm4A-6cm4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo sapiens) 		no annotation 5 CYH S 133
THR S 134
PHE S 331
TYR S 109
TYR S 359
 EP5  S 401 (-4.2A)
EP5  S 401 (-3.8A)
EP5  S 401 (-4.7A)
None
EP5  S 401 ( 4.9A)
 1.34A 6cm4A-6g79S:
25.8		 6cm4A-6g79S:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo sapiens) 		no annotation 5 CYH S 133
THR S 134
TRP S 327
THR S 355
TYR S 359
 EP5  S 401 (-4.2A)
EP5  S 401 (-3.8A)
None
None
EP5  S 401 ( 4.9A)
 0.82A 6cm4A-6g79S:
25.8		 6cm4A-6g79S:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo sapiens) 		no annotation 5 CYH S 133
TRP S 327
PHE S 331
THR S 355
TYR S 359
 EP5  S 401 (-4.2A)
None
EP5  S 401 (-4.7A)
None
EP5  S 401 ( 4.9A)
 0.90A 6cm4A-6g79S:
25.8		 6cm4A-6g79S:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usc PUTATIVE STYRENE
MONOOXYGENASE SMALL
COMPONENT

(Thermus
thermophilus) 		PF01613
(Flavin_Reduct) 		4 ASP A 130
ALA A  37
SER A  53
PHE A  13
 None
FMN  A1179 (-3.5A)
None
None
 1.36A 6cm4A-1uscA:
undetectable		 6cm4A-1uscA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gb3 ASPARTATE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		4 ASP A 228
ALA A 236
SER A 273
PHE A 284
 None
 1.26A 6cm4A-2gb3A:
0.0		 6cm4A-2gb3A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASP A 181
ALA A 506
SER A 510
PHE A 141
 NAG  A 710 ( 3.4A)
None
None
None
 1.33A 6cm4A-3dkhA:
0.0		 6cm4A-3dkhA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASP A 182
ALA A 507
SER A 511
PHE A 142
 NAG  A 700 (-3.5A)
None
None
NAG  A 700 (-4.5A)
 1.34A 6cm4A-3ppsA:
0.0		 6cm4A-3ppsA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		4 ASP A 242
ALA A  86
SER A  95
PHE A 276
 None
 1.40A 6cm4A-3syjA:
0.0		 6cm4A-3syjA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyt ESTERASE A

(Paenarthrobacter
nitroguajacolicus) 		PF00144
(Beta-lactamase) 		4 ASP A 323
ALA A 319
SER A 308
PHE A 301
 None
 1.27A 6cm4A-3zytA:
0.0		 6cm4A-3zytA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2o YMDB
PHOSPHODIESTERASE

(Bacillus
subtilis) 		PF13277
(YmdB) 		4 ASP A 243
ALA A 191
SER A 169
PHE A  33
 None
 0.97A 6cm4A-4b2oA:
0.0		 6cm4A-4b2oA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 ASP A 344
ALA A 399
SER A 451
PHE A 388
 None
 1.35A 6cm4A-4bziA:
0.4		 6cm4A-4bziA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mu9 GLYCOSIDE HYDROLASE
FAMILY 73

(Bacteroides
thetaiotaomicron) 		PF03663
(Glyco_hydro_76) 		4 ASP A 244
ALA A 201
SER A 199
PHE A 315
 None
 1.23A 6cm4A-4mu9A:
0.0		 6cm4A-4mu9A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgz ANTIZYME INHIBITOR 1
ORNITHINE
DECARBOXYLASE
ANTIZYME 1

(Homo sapiens;
Homo sapiens) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N)
PF02100
(ODC_AZ) 		4 ASP A 387
ALA A  88
SER A  90
PHE B 192
 None
 1.41A 6cm4A-4zgzA:
undetectable		 6cm4A-4zgzA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhj MG-CHELATASE SUBUNIT
CHLH

(Synechocystis
sp. PCC 6803) 		PF02514
(CobN-Mg_chel)
PF11965
(DUF3479) 		4 ASP A 988
ALA A 942
SER A 659
PHE A1042
 None
 1.48A 6cm4A-4zhjA:
undetectable		 6cm4A-4zhjA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5b DCC-INTERACTING
PROTEIN 13-ALPHA

(Homo sapiens) 		PF00169
(PH)
PF16746
(BAR_3) 		4 ASP A  15
ALA A 142
SER A 170
PHE A 133
 None
 1.46A 6cm4A-5c5bA:
4.3		 6cm4A-5c5bA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipy FLAVIN-CONTAINING
MONOOXYGENASE

(Roseovarius
nubinhibens) 		PF00743
(FMO-like) 		4 ASP A 392
ALA A 382
SER A 388
PHE A 320
 None
 1.40A 6cm4A-5ipyA:
undetectable		 6cm4A-5ipyA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv9 LPS-ASSEMBLY PROTEIN
LPTD
LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Klebsiella
pneumoniae;
Klebsiella
pneumoniae) 		PF03968
(OstA)
PF04453
(OstA_C)
PF04390
(LptE) 		4 ASP B 141
ALA A 305
SER A 336
PHE A 353
 None
 1.50A 6cm4A-5iv9B:
0.1		 6cm4A-5iv9B:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		4 ASP A  68
ALA A  59
SER A  81
PHE A 816
 None
 1.48A 6cm4A-5lq3A:
undetectable		 6cm4A-5lq3A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t4x RETINAL ROD
RHODOPSIN-SENSITIVE
CGMP 3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT DELTA

(Mus musculus) 		no annotation 4 ASP A  37
ALA A  68
SER A  66
PHE A 133
 None
 1.14A 6cm4A-5t4xA:
undetectable		 6cm4A-5t4xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		4 ASP A 655
ALA A 902
SER A 908
PHE A 930
 None
 1.46A 6cm4A-5u1sA:
2.4		 6cm4A-5u1sA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1

(Homo sapiens) 		PF00005
(ABC_tran)
PF12698
(ABC2_membrane_3) 		4 ASP A1706
ALA A1766
SER A1757
PHE A1675
 None
 1.40A 6cm4A-5xjyA:
1.3		 6cm4A-5xjyA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		no annotation 4 ASP A 114
ALA A 122
SER A 197
PHE A 389
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.3A)
8NU  A2001 ( 3.6A)
8NU  A2001 ( 4.5A)
 0.01A 6cm4A-6cm4A:
55.7		 6cm4A-6cm4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dft


(;
) 		no annotation
no annotation 		4 ASP B 316
ALA A 398
SER A 404
PHE B 118
 NAD  B 500 (-3.6A)
NAD  A 502 (-3.1A)
NAD  B 500 (-3.8A)
None
 1.38A 6cm4A-6dftB:
undetectable		 6cm4A-6dftB:
undetectable